IMP: Integrative Multi-species Prediction

Mus musculus

77 known processes

Ptpn22

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

(Aliases: Ptpn8,PEP,70zpep)

Ensembl: ENSMUSG00000027843
Entrez: 19260
UniProtKB: P29352

Process Predictions
Disease Predictions

Ptpn22 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cation transport	GO:0006812	399	0.764
amine metabolic process	GO:0009308	45	0.760
positive regulation of cellular amine metabolic process	GO:0033240	5	0.746
t cell proliferation	GO:0042098	120	0.723
release of cytochrome c from mitochondria	GO:0001836	23	0.722
defense response to other organism	GO:0098542	197	0.718
immune response activating signal transduction	GO:0002757	116	0.704
immune effector process	GO:0002252	321	0.698
dephosphorylation	GO:0016311	129	0.661
cell activation involved in immune response	GO:0002263	126	0.623
regulation of homotypic cell cell adhesion	GO:0034110	13	0.603
regulation of alpha beta t cell differentiation	GO:0046637	35	0.596
regulation of lymphocyte activation	GO:0051249	240	0.594
immune response regulating signaling pathway	GO:0002764	125	0.594
leukocyte mediated immunity	GO:0002443	174	0.592
t cell differentiation	GO:0030217	174	0.589
positive regulation of gamma delta t cell differentiation	GO:0045588	6	0.580
single organism cell adhesion	GO:0098602	156	0.573
myeloid leukocyte activation	GO:0002274	83	0.551
positive regulation of alpha beta t cell differentiation	GO:0046638	28	0.548
t helper 2 cell cytokine production	GO:0035745	4	0.533
cellular nitrogen compound catabolic process	GO:0044270	280	0.526
interleukin 2 production	GO:0032623	33	0.521
negative regulation of cellular amine metabolic process	GO:0033239	1	0.517
ras protein signal transduction	GO:0007265	77	0.513
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.512
positive regulation of innate immune response	GO:0045089	80	0.511
gtp catabolic process	GO:0006184	143	0.511
cytoplasmic transport	GO:0016482	234	0.510
t cell differentiation in thymus	GO:0033077	77	0.505
regulation of leukocyte proliferation	GO:0070663	121	0.491	Human
alpha beta t cell differentiation	GO:0046632	69	0.481
guanosine containing compound catabolic process	GO:1901069	144	0.479
b cell receptor signaling pathway	GO:0050853	20	0.469
positive t cell selection	GO:0043368	23	0.468
negative regulation of protein metabolic process	GO:0051248	282	0.456
positive regulation of calcium mediated signaling	GO:0050850	15	0.446
negative regulation of t cell mediated cytotoxicity	GO:0001915	3	0.442
regulation of cytokine biosynthetic process	GO:0042035	59	0.437
regulation of alpha beta t cell activation	GO:0046634	53	0.433
regulation of t cell proliferation	GO:0042129	92	0.430
cellular amine metabolic process	GO:0044106	44	0.430
release of sequestered calcium ion into cytosol	GO:0051209	42	0.429
regulation of t cell activation	GO:0050863	170	0.421
lipid biosynthetic process	GO:0008610	179	0.418
leukocyte cell cell adhesion	GO:0007159	14	0.410
regulation of leukocyte differentiation	GO:1902105	159	0.409
regulation of mast cell activation	GO:0033003	21	0.406
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.406
cytokine metabolic process	GO:0042107	71	0.405
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.404
production of molecular mediator of immune response	GO:0002440	103	0.399
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.399
regulation of t cell differentiation	GO:0045580	83	0.396
organic cyclic compound catabolic process	GO:1901361	295	0.395
b cell proliferation	GO:0042100	53	0.394
leukocyte differentiation	GO:0002521	342	0.394
negative regulation of cellular component organization	GO:0051129	194	0.384
positive regulation of alpha beta t cell activation	GO:0046635	39	0.377
positive regulation of interleukin 10 secretion	GO:2001181	1	0.377
positive regulation of cell activation	GO:0050867	158	0.375
cellular amino acid metabolic process	GO:0006520	103	0.372
regulation of hydrolase activity	GO:0051336	246	0.369
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.369
cytokine production	GO:0001816	319	0.363
positive regulation of t cell activation	GO:0050870	101	0.363
adaptive immune response	GO:0002250	155	0.358
positive regulation of t cell differentiation	GO:0045582	52	0.356
lymphocyte activation involved in immune response	GO:0002285	93	0.356
regulation of cellular ketone metabolic process	GO:0010565	66	0.356
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.349
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.339
positive regulation of gtp catabolic process	GO:0033126	85	0.337
innate immune response activating signal transduction	GO:0002758	50	0.334
rho protein signal transduction	GO:0007266	32	0.334
lymphocyte differentiation	GO:0030098	242	0.334
nucleoside catabolic process	GO:0009164	206	0.333
cytokine biosynthetic process	GO:0042089	68	0.327
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.324
protein maturation	GO:0051604	176	0.324
establishment of protein localization to organelle	GO:0072594	118	0.322
ribonucleoside catabolic process	GO:0042454	206	0.321
regulation of lymphocyte mediated immunity	GO:0002706	84	0.321
small gtpase mediated signal transduction	GO:0007264	97	0.317
regulation of alpha beta t cell proliferation	GO:0046640	18	0.312
regulation of ras protein signal transduction	GO:0046578	114	0.312
positive regulation of t helper 2 cell cytokine production	GO:2000553	3	0.310
regulation of cellular amino acid metabolic process	GO:0006521	5	0.310
cd4 positive alpha beta t cell cytokine production	GO:0035743	4	0.307
guanosine containing compound metabolic process	GO:1901068	144	0.303
defense response to bacterium	GO:0042742	119	0.297
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.295
response to granulocyte macrophage colony stimulating factor	GO:0097012	3	0.294
purine ribonucleotide metabolic process	GO:0009150	290	0.291
actin filament organization	GO:0007015	113	0.281
single organismal cell cell adhesion	GO:0016337	131	0.281
reactive oxygen species metabolic process	GO:0072593	84	0.279
cell adhesion	GO:0007155	329	0.278
regulation of insulin receptor signaling pathway	GO:0046626	21	0.277
negative thymic t cell selection	GO:0045060	12	0.275
glycosyl compound catabolic process	GO:1901658	206	0.274
nucleoside phosphate metabolic process	GO:0006753	338	0.272
nitrogen compound transport	GO:0071705	271	0.270
purine nucleotide catabolic process	GO:0006195	211	0.270
organonitrogen compound catabolic process	GO:1901565	264	0.268
t cell mediated immunity	GO:0002456	50	0.267
homeostasis of number of cells	GO:0048872	210	0.264
regulation of gtp catabolic process	GO:0033124	113	0.264
cellular ketone metabolic process	GO:0042180	84	0.263
nucleocytoplasmic transport	GO:0006913	139	0.263
positive regulation of t cell mediated immunity	GO:0002711	24	0.261
positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process	GO:0045425	2	0.259
organelle fusion	GO:0048284	28	0.259
female gamete generation	GO:0007292	74	0.252
purine ribonucleotide catabolic process	GO:0009154	208	0.252
purine containing compound metabolic process	GO:0072521	311	0.248
ral protein signal transduction	GO:0032484	2	0.245
plasma membrane organization	GO:0007009	90	0.244
regulation of leukocyte mediated immunity	GO:0002703	104	0.243
cellular lipid metabolic process	GO:0044255	323	0.242
regulation of t helper 2 cell cytokine production	GO:2000551	3	0.241
negative regulation of cellular protein metabolic process	GO:0032269	247	0.239
regulation of rho protein signal transduction	GO:0035023	71	0.239
interleukin 10 secretion	GO:0072608	4	0.237
lymphocyte mediated immunity	GO:0002449	139	0.234
membrane tubulation	GO:0097320	4	0.233
leukocyte activation involved in immune response	GO:0002366	126	0.232
protein localization to membrane	GO:0072657	108	0.231
positive regulation of cytokine production	GO:0001819	174	0.230
regulation of purine nucleotide catabolic process	GO:0033121	122	0.228
nucleoside metabolic process	GO:0009116	246	0.225
regulation of nucleotide catabolic process	GO:0030811	122	0.225
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.224
establishment of organelle localization	GO:0051656	122	0.221
positive regulation of cell death	GO:0010942	224	0.220
purine nucleoside catabolic process	GO:0006152	205	0.220
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.218
positive regulation of defense response	GO:0031349	124	0.213
positive regulation of programmed cell death	GO:0043068	218	0.211
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.211
protein processing	GO:0016485	163	0.210
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.209
organophosphate catabolic process	GO:0046434	232	0.207
t cell activation involved in immune response	GO:0002286	43	0.205
nucleotide metabolic process	GO:0009117	332	0.205
positive regulation of gtpase activity	GO:0043547	85	0.205
positive regulation of leukocyte proliferation	GO:0070665	73	0.205
c4 dicarboxylate transport	GO:0015740	3	0.204
cd4 positive alpha beta t cell activation	GO:0035710	45	0.203
ossification	GO:0001503	216	0.203
protein import into nucleus	GO:0006606	95	0.202
positive regulation of hydrolase activity	GO:0051345	148	0.200
vesicle fusion	GO:0006906	16	0.200
positive thymic t cell selection	GO:0045059	13	0.198
regulation of cellular amine metabolic process	GO:0033238	20	0.197
positive regulation of intracellular transport	GO:0032388	70	0.197
inflammatory response	GO:0006954	244	0.196
t helper cell differentiation	GO:0042093	28	0.196
regulation of cell adhesion	GO:0030155	154	0.195
labyrinthine layer blood vessel development	GO:0060716	21	0.193
positive regulation of lymphocyte differentiation	GO:0045621	61	0.193
regulation of response to wounding	GO:1903034	189	0.191
positive regulation of t cell cytokine production	GO:0002726	5	0.191
negative regulation of adaptive immune response	GO:0002820	25	0.191
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.190
regulation of granulocyte macrophage colony stimulating factor biosynthetic process	GO:0045423	2	0.189
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	17	0.189
glycosyl compound metabolic process	GO:1901657	246	0.188
purine containing compound catabolic process	GO:0072523	213	0.187
positive regulation of adaptive immune response	GO:0002821	61	0.187
microtubule based process	GO:0007017	236	0.186
interleukin 2 biosynthetic process	GO:0042094	15	0.186
regulation of protein localization	GO:0032880	231	0.185
vesicle organization	GO:0016050	60	0.184
regulation of release of cytochrome c from mitochondria	GO:0090199	11	0.183
positive regulation of rho gtpase activity	GO:0032321	41	0.182
regulation of lymphocyte differentiation	GO:0045619	107	0.181
nucleoside phosphate catabolic process	GO:1901292	222	0.181
response to organic cyclic compound	GO:0014070	198	0.181
purine nucleotide metabolic process	GO:0006163	302	0.180
t cell differentiation involved in immune response	GO:0002292	30	0.179
regulation of actin polymerization or depolymerization	GO:0008064	45	0.178
negative regulation of phosphorylation	GO:0042326	166	0.177
regulation of mitochondrion organization	GO:0010821	27	0.176
regulation of vesicle mediated transport	GO:0060627	139	0.175
negative regulation of protein phosphorylation	GO:0001933	126	0.173
positive regulation of response to wounding	GO:1903036	66	0.172
negative regulation of phosphate metabolic process	GO:0045936	184	0.172
peptidyl amino acid modification	GO:0018193	336	0.171
regulation of protein maturation	GO:1903317	96	0.171
regulation of interleukin 2 production	GO:0032663	28	0.170
single organism nuclear import	GO:1902593	95	0.169
leukocyte proliferation	GO:0070661	172	0.168	Human
negative regulation of insulin receptor signaling pathway	GO:0046627	14	0.168
carboxylic acid transport	GO:0046942	100	0.168
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002823	23	0.168
interleukin 4 production	GO:0032633	24	0.167
purine nucleoside metabolic process	GO:0042278	241	0.164
regulation of ral gtpase activity	GO:0032315	4	0.164
positive regulation of lymphocyte proliferation	GO:0050671	70	0.163
ribose phosphate metabolic process	GO:0019693	291	0.162
lymphocyte proliferation	GO:0046651	164	0.160	Human
b cell apoptotic process	GO:0001783	19	0.160
carbohydrate derivative catabolic process	GO:1901136	231	0.160
negative regulation of b cell proliferation	GO:0030889	13	0.158
nucleotide catabolic process	GO:0009166	217	0.158
negative regulation of hydrolase activity	GO:0051346	71	0.157
response to oxidative stress	GO:0006979	123	0.153
positive regulation of nucleotide catabolic process	GO:0030813	88	0.153
toll like receptor signaling pathway	GO:0002224	38	0.152
immunoglobulin production	GO:0002377	73	0.151
regulation of lymphocyte proliferation	GO:0050670	117	0.151	Human
positive regulation of immune effector process	GO:0002699	107	0.150
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.150
regulation of blood coagulation	GO:0030193	28	0.149
heterocycle catabolic process	GO:0046700	280	0.148
regulation of cd4 positive alpha beta t cell activation	GO:2000514	24	0.147
g protein coupled receptor signaling pathway	GO:0007186	243	0.147
ceramide biosynthetic process	GO:0046513	20	0.147
second messenger mediated signaling	GO:0019932	73	0.147
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.146
organelle localization	GO:0051640	179	0.145
b cell activation	GO:0042113	161	0.145
positive regulation of gamma delta t cell activation	GO:0046645	6	0.144
myeloid cell homeostasis	GO:0002262	114	0.143
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.142
b cell differentiation	GO:0030183	78	0.141
alpha beta t cell activation	GO:0046631	91	0.140
regulation of actin cytoskeleton organization	GO:0032956	84	0.138
activation of immune response	GO:0002253	138	0.138
exocytosis	GO:0006887	121	0.137
regulation of ras gtpase activity	GO:0032318	88	0.136
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.136
thymic t cell selection	GO:0045061	22	0.136
regulation of interferon gamma production	GO:0032649	57	0.136
labyrinthine layer development	GO:0060711	49	0.136
peptidyl serine phosphorylation	GO:0018105	74	0.134
positive regulation of interleukin 5 secretion	GO:2000664	1	0.134
granulocyte activation	GO:0036230	10	0.132
protein import	GO:0017038	101	0.131
regulation of cell activation	GO:0050865	289	0.130
natural killer cell activation	GO:0030101	44	0.130	Human
cellular response to cytokine stimulus	GO:0071345	189	0.130
gtp metabolic process	GO:0046039	144	0.129
regulation of b cell proliferation	GO:0030888	39	0.128
positive regulation of kinase activity	GO:0033674	155	0.127
positive regulation of lymphocyte activation	GO:0051251	140	0.127
regulation of vesicle fusion	GO:0031338	6	0.127
nucleoside triphosphate catabolic process	GO:0009143	205	0.126
regulation of defense response	GO:0031347	233	0.126
regulation of superoxide metabolic process	GO:0090322	8	0.125
regulation of intracellular protein transport	GO:0033157	82	0.124
negative regulation of protein maturation	GO:1903318	79	0.124
regulation of establishment of protein localization	GO:0070201	181	0.124
purine ribonucleoside metabolic process	GO:0046128	241	0.124
regulation of secretion	GO:0051046	274	0.124
intracellular protein transport	GO:0006886	204	0.123
sphingolipid catabolic process	GO:0030149	7	0.122
nucleoside triphosphate metabolic process	GO:0009141	230	0.122
positive regulation of t cell proliferation	GO:0042102	52	0.121
regulation of ion transport	GO:0043269	215	0.120
response to peptide	GO:1901652	136	0.120
apoptotic mitochondrial changes	GO:0008637	48	0.119
negative regulation of phosphorus metabolic process	GO:0010563	184	0.119
b cell homeostasis	GO:0001782	34	0.119
interleukin 10 production	GO:0032613	23	0.118
membrane fusion	GO:0061025	38	0.118
t cell selection	GO:0045058	34	0.117
membrane organization	GO:0061024	245	0.117
regulation of secretion by cell	GO:1903530	249	0.117
mast cell mediated immunity	GO:0002448	20	0.117
positive regulation of ras gtpase activity	GO:0032320	65	0.116
regulation of hemostasis	GO:1900046	28	0.114
regulation of b cell differentiation	GO:0045577	23	0.114
regulation of kinase activity	GO:0043549	249	0.114
regulation of interleukin 2 biosynthetic process	GO:0045076	13	0.112
sphingolipid metabolic process	GO:0006665	45	0.110
t cell activation	GO:0042110	289	0.110
regulation of interleukin 10 production	GO:0032653	21	0.109
regulation of adaptive immune response	GO:0002819	90	0.109
extrinsic apoptotic signaling pathway	GO:0097191	126	0.109
ribonucleoside metabolic process	GO:0009119	245	0.108
nuclear import	GO:0051170	95	0.108
ribonucleotide metabolic process	GO:0009259	291	0.108
glial cell development	GO:0021782	54	0.108
purine ribonucleoside catabolic process	GO:0046130	205	0.108
oocyte differentiation	GO:0009994	35	0.107
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.107
antigen receptor mediated signaling pathway	GO:0050851	64	0.107
protein secretion	GO:0009306	111	0.106
vesicle localization	GO:0051648	86	0.106
positive regulation of cytokine secretion	GO:0050715	41	0.106
insulin receptor signaling pathway	GO:0008286	49	0.105
peptidyl serine modification	GO:0018209	83	0.105
positive regulation of t helper 2 cell activation	GO:2000570	2	0.105
granulocyte chemotaxis	GO:0071621	39	0.104
negative regulation of immune system process	GO:0002683	209	0.104
ceramide metabolic process	GO:0006672	31	0.103
regulation of cellular response to stress	GO:0080135	159	0.101
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.100
positive regulation of interleukin 2 biosynthetic process	GO:0045086	8	0.097
protein autophosphorylation	GO:0046777	61	0.097
positive regulation of nucleoside metabolic process	GO:0045979	91	0.097
response to inorganic substance	GO:0010035	96	0.096
developmental maturation	GO:0021700	193	0.096
nucleobase containing small molecule metabolic process	GO:0055086	352	0.096
regulation of interleukin 10 secretion	GO:2001179	4	0.096
positive regulation of interleukin 13 secretion	GO:2000667	1	0.095
mitochondrion organization	GO:0007005	134	0.095
regulation of purine nucleotide metabolic process	GO:1900542	169	0.094
endocytosis	GO:0006897	168	0.093
positive regulation of cellular catabolic process	GO:0031331	148	0.092
activation of jun kinase activity	GO:0007257	15	0.092
regulation of ral protein signal transduction	GO:0032485	4	0.092
calcium mediated signaling	GO:0019722	46	0.092
interleukin 5 secretion	GO:0072603	2	0.090
organic anion transport	GO:0015711	137	0.090
regulation of intracellular transport	GO:0032386	159	0.090
regulation of nucleoside metabolic process	GO:0009118	130	0.089
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.089
positive regulation of protein modification process	GO:0031401	299	0.086
regulation of transferase activity	GO:0051338	263	0.086
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.086
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.086
regulation of cell migration	GO:0030334	219	0.086
sphingolipid biosynthetic process	GO:0030148	26	0.085
anion transport	GO:0006820	177	0.085
regulation of rho gtpase activity	GO:0032319	58	0.085
membrane lipid biosynthetic process	GO:0046467	32	0.085
peptidyl threonine modification	GO:0018210	31	0.085
endomembrane system organization	GO:0010256	147	0.084
regulation of organelle organization	GO:0033043	289	0.084
interaction with host	GO:0051701	22	0.084
positive regulation of b cell differentiation	GO:0045579	13	0.083
regulation of phospholipid catabolic process	GO:0060696	2	0.083
positive regulation of secretion by cell	GO:1903532	114	0.082
innate immune response	GO:0045087	157	0.082
cell type specific apoptotic process	GO:0097285	268	0.082
myeloid leukocyte migration	GO:0097529	57	0.082
immunoglobulin mediated immune response	GO:0016064	69	0.081
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.081
amide transport	GO:0042886	138	0.081
marginal zone b cell differentiation	GO:0002315	2	0.080
placenta development	GO:0001890	140	0.080
cellular response to growth factor stimulus	GO:0071363	197	0.080
apoptotic signaling pathway	GO:0097190	306	0.079
granulocyte macrophage colony stimulating factor production	GO:0032604	3	0.079
regulation of interleukin 4 production	GO:0032673	18	0.079
activation of ras gtpase activity	GO:0032856	11	0.078
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.078
immune complex clearance	GO:0002434	2	0.078
calcium ion transport	GO:0006816	159	0.077
aromatic compound catabolic process	GO:0019439	286	0.077
myeloid cell activation involved in immune response	GO:0002275	34	0.076
regulation of cytokine production involved in immune response	GO:0002718	26	0.076
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.075
positive regulation of leukocyte differentiation	GO:1902107	86	0.075
regulation of protein kinase activity	GO:0045859	232	0.075
sequestering of calcium ion	GO:0051208	18	0.075
regulation of t cell mediated immunity	GO:0002709	34	0.075
neutrophil chemotaxis	GO:0030593	36	0.074
regulation of granulocyte macrophage colony stimulating factor production	GO:0032645	3	0.074
granulocyte migration	GO:0097530	43	0.073
granulocyte macrophage colony stimulating factor biosynthetic process	GO:0042253	2	0.073
protein localization to organelle	GO:0033365	185	0.073
microtubule cytoskeleton organization	GO:0000226	157	0.072
regulation of metal ion transport	GO:0010959	106	0.072
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.072
positive regulation of killing of cells of other organism	GO:0051712	3	0.071
regulation of innate immune response	GO:0045088	91	0.071
negative regulation of cell adhesion	GO:0007162	45	0.070
regulation of cd4 positive alpha beta t cell differentiation	GO:0043370	21	0.070
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.070
membrane lipid metabolic process	GO:0006643	53	0.069
cellular response to molecule of fungal origin	GO:0071226	2	0.069
inorganic ion transmembrane transport	GO:0098660	234	0.069
regulation of interleukin 5 secretion	GO:2000662	2	0.069
phospholipid metabolic process	GO:0006644	87	0.068
regulation of apoptotic signaling pathway	GO:2001233	197	0.068
muscle cell differentiation	GO:0042692	261	0.068
response to endoplasmic reticulum stress	GO:0034976	53	0.068
response to drug	GO:0042493	75	0.067
homotypic cell cell adhesion	GO:0034109	28	0.067
regulation of gamma delta t cell differentiation	GO:0045586	9	0.067
intracellular mrna localization	GO:0008298	4	0.067
regulation of b cell activation	GO:0050864	81	0.067
generation of precursor metabolites and energy	GO:0006091	103	0.067
b cell mediated immunity	GO:0019724	71	0.066
cellular response to molecule of bacterial origin	GO:0071219	83	0.066
monocarboxylic acid biosynthetic process	GO:0072330	61	0.066
negative regulation of intracellular signal transduction	GO:1902532	167	0.066
regulation of mapk cascade	GO:0043408	248	0.066
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.065
i kappab kinase nf kappab signaling	GO:0007249	85	0.065
interspecies interaction between organisms	GO:0044419	83	0.065
positive regulation of homeostatic process	GO:0032846	64	0.065
neuronal action potential	GO:0019228	54	0.064
positive regulation of vesicle fusion	GO:0031340	2	0.064
regulation of peptidase activity	GO:0052547	96	0.064
regulation of cytoskeleton organization	GO:0051493	122	0.064
peptidyl tyrosine modification	GO:0018212	145	0.064
actin filament polymerization	GO:0030041	44	0.063
divalent metal ion transport	GO:0070838	172	0.063
humoral immune response	GO:0006959	57	0.063
regulation of neutrophil differentiation	GO:0045658	2	0.063
alpha beta t cell activation involved in immune response	GO:0002287	31	0.063
positive regulation of interleukin 5 production	GO:0032754	5	0.062
regulation of cell shape	GO:0008360	39	0.062
glycogen cell differentiation involved in embryonic placenta development	GO:0060709	1	0.062
response to ethanol	GO:0045471	18	0.061
myeloid leukocyte mediated immunity	GO:0002444	42	0.061
superoxide metabolic process	GO:0006801	27	0.061
neutrophil activation	GO:0042119	9	0.061
negative regulation of b cell mediated immunity	GO:0002713	7	0.061
oocyte construction	GO:0007308	2	0.061
regulation of cellular component size	GO:0032535	121	0.061
regulation of proteolysis	GO:0030162	164	0.060
positive regulation of interleukin 10 production	GO:0032733	12	0.059
inositol lipid mediated signaling	GO:0048017	41	0.059
regulation of cellular component biogenesis	GO:0044087	181	0.059
regulation of exocytosis	GO:0017157	61	0.059
interleukin 3 production	GO:0032632	3	0.058
glucose metabolic process	GO:0006006	92	0.058
t helper 2 cell activation	GO:0035712	2	0.058
positive regulation of type 2 immune response	GO:0002830	9	0.057
regulation of mast cell degranulation	GO:0043304	16	0.057
negative regulation of protein processing	GO:0010955	79	0.057
sensory organ morphogenesis	GO:0090596	242	0.057
tissue homeostasis	GO:0001894	115	0.057
positive regulation of protein phosphorylation	GO:0001934	242	0.057
regulation of interleukin 13 secretion	GO:2000665	2	0.057
mammary gland epithelium development	GO:0061180	65	0.057
negative regulation of leukocyte mediated immunity	GO:0002704	29	0.057
regulation of wound healing	GO:0061041	40	0.056
extracellular structure organization	GO:0043062	148	0.056
regulation of cytokine secretion	GO:0050707	61	0.056
autophagy	GO:0006914	45	0.056
regulation of body fluid levels	GO:0050878	162	0.056
regulation of sphingolipid biosynthetic process	GO:0090153	1	0.055
cellular response to nutrient levels	GO:0031669	64	0.055
regulation of protein transport	GO:0051223	163	0.055
regulation of protein homooligomerization	GO:0032462	3	0.054
hematopoietic progenitor cell differentiation	GO:0002244	143	0.054
cellular biogenic amine metabolic process	GO:0006576	28	0.054
regulation of coagulation	GO:0050818	31	0.053
protein targeting	GO:0006605	143	0.053
organic hydroxy compound metabolic process	GO:1901615	203	0.053
synaptic transmission	GO:0007268	329	0.053
negative regulation of cell adhesion involved in substrate bound cell migration	GO:0006933	3	0.052
negative regulation of protein modification process	GO:0031400	163	0.051
positive regulation of proteolysis	GO:0045862	85	0.051
hexose metabolic process	GO:0019318	98	0.051
regulation of cell killing	GO:0031341	40	0.051
organic acid biosynthetic process	GO:0016053	86	0.051
lateral inhibition	GO:0046331	1	0.051
coagulation	GO:0050817	78	0.050
germ cell development	GO:0007281	185	0.050
regulation of protein autophosphorylation	GO:0031952	8	0.050
response to reactive oxygen species	GO:0000302	56	0.050
positive regulation of protein targeting to membrane	GO:0090314	7	0.050
regulation of endopeptidase activity	GO:0052548	89	0.050
negative regulation of endopeptidase activity	GO:0010951	44	0.049
positive regulation of ral gtpase activity	GO:0032852	4	0.049
positive regulation of protein kinase activity	GO:0045860	144	0.049
regulation of cell cycle	GO:0051726	281	0.048
myeloid cell differentiation	GO:0030099	233	0.048
regulation of multi organism process	GO:0043900	111	0.048
oocyte axis specification	GO:0007309	2	0.048
negative regulation of endocytosis	GO:0045806	12	0.048
leukocyte apoptotic process	GO:0071887	71	0.048
cellular response to organonitrogen compound	GO:0071417	145	0.048
oocyte anterior posterior axis specification	GO:0007314	2	0.047
negative regulation of peptidase activity	GO:0010466	46	0.047
carboxylic acid biosynthetic process	GO:0046394	86	0.047
cellular amide metabolic process	GO:0043603	58	0.047
positive regulation of b cell activation	GO:0050871	49	0.047
positive regulation of organelle organization	GO:0010638	128	0.046
myotube differentiation	GO:0014902	105	0.046
positive regulation of alpha beta t cell proliferation	GO:0046641	12	0.046
mapk cascade	GO:0000165	281	0.046
leukotriene biosynthetic process	GO:0019370	5	0.046
eye photoreceptor cell differentiation	GO:0001754	41	0.045
blood coagulation	GO:0007596	76	0.045
negative regulation of release of cytochrome c from mitochondria	GO:0090201	6	0.045
lipid transport	GO:0006869	98	0.045
leukocyte migration	GO:0050900	124	0.045

Ptpn22 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
immune system disease	DOID:2914	0.921	Human
disease of anatomical entity	DOID:7	0.921	Human
musculoskeletal system disease	DOID:17	0.253	Human
hematopoietic system disease	DOID:74	0.199
primary immunodeficiency disease	DOID:612	0.124
blood protein disease	DOID:620	0.124
agammaglobulinemia	DOID:2583	0.124
common variable immunodeficiency	DOID:12177	0.124
b cell deficiency	DOID:2115	0.124
hypersensitivity reaction disease	DOID:0060056	0.094	Human
lupus erythematosus	DOID:8857	0.080	Human
hypersensitivity reaction type ii disease	DOID:417	0.080	Human
connective tissue disease	DOID:65	0.073	Human

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