IMP: Integrative Multi-species Prediction

Mus musculus

18 known processes

Capn6

calpain 6

Entrez: 12338
Ensembl: ENSMUSG00000067276
UniProtKB: Q80VZ1
UniProtKB: O35646

Process Predictions
Disease Predictions

Capn6 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axonogenesis	GO:0007409	274	0.554
axon guidance	GO:0007411	141	0.509
extracellular structure organization	GO:0043062	148	0.471
extrinsic apoptotic signaling pathway	GO:0097191	126	0.449
neural tube development	GO:0021915	160	0.448
progesterone secretion	GO:0042701	1	0.377
regulation of apoptotic signaling pathway	GO:2001233	197	0.365
cell adhesion	GO:0007155	329	0.361
neural tube closure	GO:0001843	90	0.357
central nervous system neuron development	GO:0021954	67	0.355
apoptotic signaling pathway	GO:0097190	306	0.354
signal transduction in absence of ligand	GO:0038034	55	0.319
skeletal system morphogenesis	GO:0048705	203	0.314
negative regulation of nervous system development	GO:0051961	156	0.303
urogenital system development	GO:0001655	261	0.302
negative regulation of cell proliferation	GO:0008285	296	0.297
regulation of cell adhesion	GO:0030155	154	0.289
mesonephric epithelium development	GO:0072163	94	0.283
chondrocyte development	GO:0002063	24	0.279
neuron migration	GO:0001764	122	0.279
morphogenesis of a branching epithelium	GO:0061138	193	0.278
neuron projection guidance	GO:0097485	141	0.275
muscle tissue development	GO:0060537	308	0.273	Mouse
ureteric bud morphogenesis	GO:0060675	62	0.271
ear morphogenesis	GO:0042471	118	0.269
positive regulation of ureteric bud formation	GO:0072107	3	0.267
embryonic epithelial tube formation	GO:0001838	130	0.264
renal system development	GO:0072001	225	0.257
amine metabolic process	GO:0009308	45	0.254
regulation of wnt signaling pathway	GO:0030111	123	0.254
nephron tubule morphogenesis	GO:0072078	68	0.253
mesonephric tubule development	GO:0072164	94	0.252
primary neural tube formation	GO:0014020	95	0.251
neural tube formation	GO:0001841	108	0.251
regulation of mapk cascade	GO:0043408	248	0.242
ureteric bud development	GO:0001657	94	0.242
regulation of cartilage development	GO:0061035	44	0.238
pallium development	GO:0021543	120	0.236
anatomical structure homeostasis	GO:0060249	145	0.233
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.233
limb development	GO:0060173	166	0.228
regulation of cell motility	GO:2000145	236	0.226
syncytiotrophoblast cell differentiation involved in labyrinthine layer development	GO:0060715	2	0.222
positive regulation of nervous system development	GO:0051962	221	0.219
mesonephros development	GO:0001823	97	0.217
extracellular matrix organization	GO:0030198	147	0.215
chondrocyte differentiation	GO:0002062	72	0.212
kidney epithelium development	GO:0072073	121	0.201
collagen fibril organization	GO:0030199	32	0.201
ras protein signal transduction	GO:0007265	77	0.198
gastrulation	GO:0007369	116	0.194
regulation of cellular amine metabolic process	GO:0033238	20	0.189
mesonephric tubule morphogenesis	GO:0072171	63	0.189
trachea cartilage morphogenesis	GO:0060535	4	0.188
formation of primary germ layer	GO:0001704	77	0.187
development of primary sexual characteristics	GO:0045137	143	0.183
wnt signaling pathway	GO:0016055	188	0.182
appendage morphogenesis	GO:0035107	149	0.181
actin cytoskeleton organization	GO:0030036	220	0.180	Mouse
digestive system development	GO:0055123	200	0.180
cell matrix adhesion	GO:0007160	68	0.179
nephron tubule development	GO:0072080	84	0.176
ear development	GO:0043583	200	0.175
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.174
positive regulation of secondary heart field cardioblast proliferation	GO:0072513	4	0.174
digestive tract morphogenesis	GO:0048546	147	0.166
embryonic skeletal system morphogenesis	GO:0048704	91	0.165
ossification	GO:0001503	216	0.164
bone development	GO:0060348	120	0.161
mapk cascade	GO:0000165	281	0.161
cellular amine metabolic process	GO:0044106	44	0.159
tube formation	GO:0035148	140	0.156
striated muscle tissue development	GO:0014706	293	0.156	Mouse
response to acid chemical	GO:0001101	111	0.154	Mouse
skeletal system development	GO:0001501	356	0.151
smoothened signaling pathway	GO:0007224	105	0.149
kidney development	GO:0001822	213	0.149
cerebellum vasculature development	GO:0061300	1	0.147
limb morphogenesis	GO:0035108	149	0.147
embryonic skeletal system development	GO:0048706	120	0.146
endochondral bone morphogenesis	GO:0060350	50	0.145
negative regulation of growth	GO:0045926	99	0.144
cell type specific apoptotic process	GO:0097285	268	0.144	Mouse
regulation of cell migration	GO:0030334	219	0.141
cell substrate adhesion	GO:0031589	130	0.140
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.138
endodermal cell fate specification	GO:0001714	4	0.137
organelle assembly	GO:0070925	177	0.137	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.135
synaptic transmission	GO:0007268	329	0.134
sensory organ morphogenesis	GO:0090596	242	0.134
kidney morphogenesis	GO:0060993	83	0.134
appendage development	GO:0048736	166	0.134
body morphogenesis	GO:0010171	45	0.134
telencephalon development	GO:0021537	186	0.132
regulation of protein transport	GO:0051223	163	0.129
branching morphogenesis of an epithelial tube	GO:0048754	159	0.127
astrocyte fate commitment	GO:0060018	4	0.125
dorsal ventral axon guidance	GO:0033563	3	0.124
proteoglycan metabolic process	GO:0006029	38	0.124
gonad development	GO:0008406	141	0.123
mesonephric duct morphogenesis	GO:0072180	4	0.123
positive regulation of cell projection organization	GO:0031346	95	0.122
angiogenesis	GO:0001525	201	0.122
regulation of protein kinase activity	GO:0045859	232	0.120
blood vessel morphogenesis	GO:0048514	285	0.120
stem cell differentiation	GO:0048863	268	0.120
camera type eye development	GO:0043010	266	0.120
endoderm formation	GO:0001706	20	0.120
epithelial tube formation	GO:0072175	130	0.119
regulation of neuron projection development	GO:0010975	169	0.118
hindbrain development	GO:0030902	128	0.117
positive regulation of protein phosphorylation	GO:0001934	242	0.116
regulation of neuron differentiation	GO:0045664	281	0.115
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.115
notochord development	GO:0030903	20	0.114
forebrain development	GO:0030900	302	0.114
positive regulation of protein modification process	GO:0031401	299	0.114
mesoderm formation	GO:0001707	62	0.113
cell aggregation	GO:0098743	18	0.113
wnt signaling pathway involved in somitogenesis	GO:0090244	4	0.113
morphogenesis of a branching structure	GO:0001763	203	0.110
regionalization	GO:0003002	337	0.110
negative regulation of hepatocyte differentiation	GO:0070367	1	0.108
establishment of neuroblast polarity	GO:0045200	1	0.108
somite development	GO:0061053	81	0.106
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.105
somitogenesis	GO:0001756	69	0.104
central nervous system projection neuron axonogenesis	GO:0021952	21	0.102
lung development	GO:0030324	164	0.101
anion transport	GO:0006820	177	0.101
chemotaxis	GO:0006935	247	0.101
embryonic appendage morphogenesis	GO:0035113	126	0.100
embryonic limb morphogenesis	GO:0030326	126	0.099
nephron development	GO:0072006	109	0.098
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.098
central nervous system neuron differentiation	GO:0021953	162	0.098
regulation of neuron migration	GO:2001222	22	0.097
regulation of cellular amino acid metabolic process	GO:0006521	5	0.097
gland development	GO:0048732	330	0.097	Mouse
palate development	GO:0060021	76	0.096
regulation of chondrocyte differentiation	GO:0032330	33	0.094
rho protein signal transduction	GO:0007266	32	0.094
small gtpase mediated signal transduction	GO:0007264	97	0.093
non canonical wnt signaling pathway	GO:0035567	33	0.093
negative regulation of neuron projection development	GO:0010977	50	0.093
positive regulation of glial cell proliferation	GO:0060252	4	0.091
digestive tract development	GO:0048565	190	0.091
rhythmic process	GO:0048511	174	0.088
regulation of smoothened signaling pathway	GO:0008589	58	0.086
regulation of ras protein signal transduction	GO:0046578	114	0.086
sensory perception of mechanical stimulus	GO:0050954	107	0.085
cellular response to acid chemical	GO:0071229	68	0.085	Mouse
mesenchymal cell proliferation involved in ureter development	GO:0072198	4	0.084
lipid localization	GO:0010876	126	0.083
negative regulation of synapse assembly	GO:0051964	3	0.082
skeletal muscle cell differentiation	GO:0035914	66	0.082
cellular ketone metabolic process	GO:0042180	84	0.081
embryonic nail plate morphogenesis	GO:0035880	3	0.080
dendrite development	GO:0016358	115	0.080
regulation of embryonic development	GO:0045995	71	0.080
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.080
regulation of cell growth	GO:0001558	91	0.079
smooth muscle tissue development	GO:0048745	22	0.079
regulation of canonical wnt signaling pathway	GO:0060828	82	0.078
neural fold elevation formation	GO:0021502	1	0.077
negative regulation of gastrulation	GO:2000542	3	0.077
positive regulation of neuron projection development	GO:0010976	79	0.076
positive regulation of non canonical wnt signaling pathway	GO:2000052	6	0.075
pyramidal neuron migration	GO:0021852	1	0.075
sensory perception of sound	GO:0007605	97	0.074
tube closure	GO:0060606	91	0.073
negative regulation of phospholipase activity	GO:0010519	4	0.072
cartilage development	GO:0051216	140	0.072
positive regulation of apoptotic process	GO:0043065	217	0.071	Mouse
cellular response to external stimulus	GO:0071496	88	0.071
developmental cell growth	GO:0048588	84	0.071
cellular response to lipid	GO:0071396	145	0.071
central nervous system neuron axonogenesis	GO:0021955	28	0.070
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.069
bone morphogenesis	GO:0060349	78	0.069
spinal cord ventral commissure morphogenesis	GO:0021965	2	0.069
lipid transport	GO:0006869	98	0.067
muscle cell differentiation	GO:0042692	261	0.067	Mouse
aorta morphogenesis	GO:0035909	22	0.067
nephron epithelium morphogenesis	GO:0072088	68	0.067
cerebellum vasculature morphogenesis	GO:0061301	1	0.066
inner ear morphogenesis	GO:0042472	101	0.066
regulation of catenin import into nucleus	GO:0035412	5	0.066
renal tubule development	GO:0061326	87	0.066
connective tissue development	GO:0061448	179	0.065
positive regulation of programmed cell death	GO:0043068	218	0.065	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.064
cell growth	GO:0016049	130	0.064
positive regulation of neuron differentiation	GO:0045666	141	0.064
regulation of establishment of protein localization	GO:0070201	181	0.063
cardiac neural crest cell migration involved in outflow tract morphogenesis	GO:0003253	3	0.063
positive regulation of stem cell proliferation	GO:2000648	59	0.063
regulation of cell substrate adhesion	GO:0010810	73	0.063
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000802	1	0.063
development of primary male sexual characteristics	GO:0046546	88	0.062
stem cell development	GO:0048864	219	0.061
renal tubule morphogenesis	GO:0061333	72	0.061
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.060
jnk cascade	GO:0007254	72	0.060
epithelial tube morphogenesis	GO:0060562	303	0.060
positive regulation of mesenchymal cell proliferation involved in ureter development	GO:2000729	3	0.059
neural precursor cell proliferation	GO:0061351	121	0.059
organelle localization	GO:0051640	179	0.059
peptidyl amino acid modification	GO:0018193	336	0.059
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.059
negative regulation of cell development	GO:0010721	169	0.058
positive regulation of smoothened signaling pathway	GO:0045880	23	0.058
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.058	Mouse
positive regulation of cell development	GO:0010720	237	0.058
regulation of kinase activity	GO:0043549	249	0.058
carbon catabolite repression of transcription from rna polymerase ii promoter	GO:0000437	1	0.057
muscle cell development	GO:0055001	133	0.057	Mouse
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.057
cellular response to growth factor stimulus	GO:0071363	197	0.057
cell fate commitment	GO:0045165	210	0.057
morphogenesis of embryonic epithelium	GO:0016331	159	0.057
biomineral tissue development	GO:0031214	64	0.056
positive regulation of cell death	GO:0010942	224	0.056	Mouse
middle ear morphogenesis	GO:0042474	23	0.056
syncytium formation by plasma membrane fusion	GO:0000768	42	0.056	Mouse
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.055
sensory perception	GO:0007600	245	0.055
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.054
innate immune response	GO:0045087	157	0.054
placenta development	GO:0001890	140	0.054
negative regulation of neuron death	GO:1901215	98	0.054
glial cell differentiation	GO:0010001	131	0.054
regulation of ossification	GO:0030278	112	0.053
regulation of chorionic trophoblast cell proliferation	GO:1901382	1	0.053
head morphogenesis	GO:0060323	34	0.053
regulation of stem cell proliferation	GO:0072091	78	0.053
single organism cell adhesion	GO:0098602	156	0.053
heart morphogenesis	GO:0003007	178	0.053
morphogenesis of a polarized epithelium	GO:0001738	37	0.052
positive regulation of catenin import into nucleus	GO:0035413	2	0.051
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.051
neuron death	GO:0070997	154	0.050
cell proliferation in hindbrain	GO:0021534	10	0.050
multicellular organismal homeostasis	GO:0048871	164	0.050
carbohydrate homeostasis	GO:0033500	128	0.050
positive regulation of cellular amine metabolic process	GO:0033240	5	0.050
response to organic cyclic compound	GO:0014070	198	0.049
leukocyte differentiation	GO:0002521	342	0.049
spermatogenesis	GO:0007283	284	0.049
negative regulation of cell adhesion	GO:0007162	45	0.049
regulation of neuron apoptotic process	GO:0043523	122	0.049
single organismal cell cell adhesion	GO:0016337	131	0.049
cerebral cortex development	GO:0021987	86	0.049
regulation of tight junction assembly	GO:2000810	2	0.048
regulation of rho protein signal transduction	GO:0035023	71	0.048
artery development	GO:0060840	53	0.048
skin development	GO:0043588	220	0.048
negative regulation of immune system process	GO:0002683	209	0.048
subpallium neuron fate commitment	GO:0060163	2	0.047
lymphocyte differentiation	GO:0030098	242	0.047
regulation of cell cycle	GO:0051726	281	0.047
positive regulation of canonical wnt signaling pathway	GO:0090263	29	0.047
positive regulation of wnt signaling pathway	GO:0030177	45	0.047
establishment or maintenance of neuroblast polarity	GO:0045196	1	0.047
developmental growth involved in morphogenesis	GO:0060560	138	0.047
stem cell proliferation	GO:0072089	117	0.047
limbic system development	GO:0021761	72	0.046
nephron morphogenesis	GO:0072028	69	0.046
establishment of planar polarity of embryonic epithelium	GO:0042249	16	0.046
cardiac chamber development	GO:0003205	108	0.046
organic acid transport	GO:0015849	101	0.046
gliogenesis	GO:0042063	141	0.046
response to growth factor	GO:0070848	198	0.046
epithelial cell development	GO:0002064	159	0.046
stem cell maintenance	GO:0019827	130	0.045
tendon cell differentiation	GO:0035990	4	0.045
embryonic eye morphogenesis	GO:0048048	29	0.045
regulation of mesenchymal cell proliferation involved in ureter development	GO:0072199	3	0.044
establishment of planar polarity involved in neural tube closure	GO:0090177	15	0.044
regulation of ureteric bud formation	GO:0072106	3	0.044
regulation of cytoskeleton organization	GO:0051493	122	0.044
regulation of b cell activation	GO:0050864	81	0.043
cell fate specification	GO:0001708	72	0.043
negative regulation of neuron differentiation	GO:0045665	101	0.043
bmp signaling pathway	GO:0030509	93	0.043
regulation of neuron death	GO:1901214	134	0.042
development of primary female sexual characteristics	GO:0046545	73	0.042
midbrain hindbrain boundary maturation	GO:0021732	1	0.042
pharynx development	GO:0060465	1	0.042
t cell activation	GO:0042110	289	0.042
regulation of protein serine threonine kinase activity	GO:0071900	157	0.042
bone mineralization	GO:0030282	54	0.042
negative regulation of wnt signaling pathway	GO:0030178	73	0.041
positive regulation of keratinocyte proliferation	GO:0010838	4	0.041
nuclear import	GO:0051170	95	0.041
negative regulation of molecular function	GO:0044092	258	0.041
myeloid cell differentiation	GO:0030099	233	0.041
bronchiole development	GO:0060435	3	0.041
retinal blood vessel morphogenesis	GO:0061304	3	0.041
mitral valve morphogenesis	GO:0003183	4	0.040
aorta smooth muscle tissue morphogenesis	GO:0060414	2	0.040
negative regulation of cell growth	GO:0030308	44	0.040
negative regulation of intracellular signal transduction	GO:1902532	167	0.040
mammary gland morphogenesis	GO:0060443	54	0.040	Mouse
cardiac muscle tissue development	GO:0048738	130	0.040
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process	GO:2000763	1	0.040
regulation of branching involved in ureteric bud morphogenesis	GO:0090189	22	0.040
asymmetric neuroblast division	GO:0055059	1	0.040
wnt signaling pathway planar cell polarity pathway	GO:0060071	27	0.040
regulation of body fluid levels	GO:0050878	162	0.040
face development	GO:0060324	38	0.039
regulation of protein import into nucleus	GO:0042306	52	0.039
mesodermal cell migration	GO:0008078	4	0.039
b cell activation	GO:0042113	161	0.039
embryonic digit morphogenesis	GO:0042733	56	0.039
carbohydrate derivative catabolic process	GO:1901136	231	0.039
axis elongation involved in somitogenesis	GO:0090245	4	0.038
nephron epithelium development	GO:0072009	92	0.038
spinal cord development	GO:0021510	81	0.038
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.038
lens morphogenesis in camera type eye	GO:0002089	24	0.038
hair cycle	GO:0042633	90	0.038
endocrine system development	GO:0035270	98	0.038
myeloid leukocyte differentiation	GO:0002573	119	0.038
cardiac muscle cell differentiation	GO:0055007	69	0.038
feeding behavior	GO:0007631	62	0.037
embryonic camera type eye development	GO:0031076	36	0.037
negative regulation of protein phosphorylation	GO:0001933	126	0.037
negative regulation of signal transduction in absence of ligand	GO:1901099	16	0.037
oocyte axis specification	GO:0007309	2	0.037
cell proliferation in forebrain	GO:0021846	30	0.037
stress activated mapk cascade	GO:0051403	80	0.037
cell differentiation involved in embryonic placenta development	GO:0060706	26	0.037
positive regulation of protein kinase activity	GO:0045860	144	0.036
cellular response to abiotic stimulus	GO:0071214	56	0.036	Mouse
regulation of cell size	GO:0008361	72	0.036
negative regulation of protein metabolic process	GO:0051248	282	0.036
peptidyl tyrosine modification	GO:0018212	145	0.036
neuron recognition	GO:0008038	25	0.036
regulation of protein localization to nucleus	GO:1900180	60	0.036
sclerotome development	GO:0061056	4	0.036
salivary gland development	GO:0007431	37	0.035
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.035
positive regulation of cell adhesion	GO:0045785	80	0.035
negative regulation of canonical wnt signaling pathway	GO:0090090	51	0.035
motor neuron axon guidance	GO:0008045	26	0.035
aorta development	GO:0035904	23	0.035
peripheral nervous system axon regeneration	GO:0014012	2	0.035
calcium mediated signaling	GO:0019722	46	0.035
regulation of cell activation	GO:0050865	289	0.035	Mouse
cardiocyte differentiation	GO:0035051	87	0.035
heart formation	GO:0060914	16	0.035
neuron apoptotic process	GO:0051402	142	0.035
semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:0071527	1	0.035
regulation of angiogenesis	GO:0045765	81	0.035
regulation of secretion by cell	GO:1903530	249	0.035
negative regulation of cellular component organization	GO:0051129	194	0.035
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	GO:0014834	3	0.034
hypophysis morphogenesis	GO:0048850	3	0.034
positive regulation of interleukin 6 secretion	GO:2000778	1	0.034
regulation of binding	GO:0051098	111	0.034
neural crest cell fate commitment	GO:0014034	1	0.034
cranial nerve morphogenesis	GO:0021602	26	0.034
mitral valve development	GO:0003174	4	0.033
compound eye development	GO:0048749	1	0.033
positive regulation of skeletal muscle cell differentiation	GO:2001016	4	0.033
autonomic nervous system development	GO:0048483	43	0.033
response to fibroblast growth factor	GO:0071774	47	0.033
tissue remodeling	GO:0048771	102	0.033	Mouse
peripheral nervous system development	GO:0007422	53	0.033
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.033
regulation of organ morphogenesis	GO:2000027	144	0.033
positive regulation of branching involved in ureteric bud morphogenesis	GO:0090190	18	0.033
organic anion transport	GO:0015711	137	0.033
peripheral nervous system neuron axonogenesis	GO:0048936	3	0.033
negative regulation of t helper 2 cell differentiation	GO:0045629	4	0.033
endodermal cell differentiation	GO:0035987	14	0.033
dna metabolic process	GO:0006259	303	0.033
otic vesicle development	GO:0071599	14	0.032
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation	GO:0003257	3	0.032
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.032
negative regulation of execution phase of apoptosis	GO:1900118	4	0.032
protein localization to organelle	GO:0033365	185	0.032
locomotory behavior	GO:0007626	195	0.032
pancreatic pp cell differentiation	GO:0003312	2	0.032
epithelial cell differentiation involved in mammary gland alveolus development	GO:0061030	4	0.032
regulation of cell projection organization	GO:0031344	206	0.032
embryonic forelimb morphogenesis	GO:0035115	32	0.032
limb bud formation	GO:0060174	10	0.032
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	3	0.032
positive regulation of ion transport	GO:0043270	65	0.032	Mouse
face morphogenesis	GO:0060325	29	0.032
homeostasis of number of cells	GO:0048872	210	0.031
regulation of transferase activity	GO:0051338	263	0.031
rac protein signal transduction	GO:0016601	13	0.031
regulation of morphogenesis of a branching structure	GO:0060688	53	0.031
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.030
organic cyclic compound catabolic process	GO:1901361	295	0.030
organelle fission	GO:0048285	170	0.030
mesenchyme development	GO:0060485	152	0.030
positive regulation of neuron projection regeneration	GO:0070572	2	0.030
regulation of response to wounding	GO:1903034	189	0.030	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.030
regulation of retina development in camera type eye	GO:1902866	3	0.030
regulation of myeloid cell differentiation	GO:0045637	96	0.030
positive regulation of kinase activity	GO:0033674	155	0.030
bone trabecula morphogenesis	GO:0061430	12	0.030
chondroblast differentiation	GO:0060591	2	0.030
peptidyl tyrosine phosphorylation	GO:0018108	143	0.030
cardiac septum morphogenesis	GO:0060411	46	0.030
epidermis development	GO:0008544	187	0.030
cardiac cell development	GO:0055006	41	0.030
germ cell development	GO:0007281	185	0.029
auditory receptor cell fate determination	GO:0042668	3	0.029
regulation of actin filament based process	GO:0032970	99	0.029
paramesonephric duct development	GO:0061205	3	0.029
astrocyte differentiation	GO:0048708	43	0.029
glial cell migration	GO:0008347	7	0.029
regulation of auditory receptor cell differentiation	GO:0045607	4	0.029
regulation of heart morphogenesis	GO:2000826	22	0.029
regulation of organelle organization	GO:0033043	289	0.029
intracellular receptor signaling pathway	GO:0030522	74	0.029
regulation of actin cytoskeleton organization	GO:0032956	84	0.029
hematopoietic progenitor cell differentiation	GO:0002244	143	0.028
cellular response to organonitrogen compound	GO:0071417	145	0.028	Mouse
metencephalon development	GO:0022037	89	0.028
protein modification by small protein conjugation	GO:0032446	187	0.028
glucose homeostasis	GO:0042593	128	0.028
acid secretion	GO:0046717	33	0.028
response to retinoic acid	GO:0032526	56	0.028
pancreatic a cell fate commitment	GO:0003326	2	0.028
cytoplasmic transport	GO:0016482	234	0.028	Mouse
embryonic heart tube formation	GO:0003144	1	0.028
cell cell signaling involved in mammary gland development	GO:0060764	2	0.028
diencephalon development	GO:0021536	63	0.028
heterocycle catabolic process	GO:0046700	280	0.028
osteoclast differentiation	GO:0030316	62	0.028
mesoderm morphogenesis	GO:0048332	64	0.027
maintenance of cell number	GO:0098727	3	0.027
phagosome maturation	GO:0090382	4	0.027
negative regulation of bmp signaling pathway	GO:0030514	35	0.027
cellular response to extracellular stimulus	GO:0031668	81	0.027
intracellular protein transport	GO:0006886	204	0.027
establishment of tissue polarity	GO:0007164	28	0.027
forelimb morphogenesis	GO:0035136	40	0.027
regulation of hepatocyte differentiation	GO:0070366	2	0.027
endoderm development	GO:0007492	45	0.026
bone marrow development	GO:0048539	3	0.026
ovulation cycle	GO:0042698	59	0.026
endocytosis	GO:0006897	168	0.026
spleen development	GO:0048536	39	0.026
response to bmp	GO:0071772	14	0.026
response to vitamin d	GO:0033280	3	0.026
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	16	0.026
positive regulation of heart induction	GO:1901321	2	0.026
intrinsic apoptotic signaling pathway	GO:0097193	132	0.026
cell proliferation in midbrain	GO:0033278	2	0.026
establishment of planar polarity involved in nephron morphogenesis	GO:0072046	1	0.026
visceral motor neuron differentiation	GO:0021524	3	0.026
positive regulation of hydrolase activity	GO:0051345	148	0.026
dna recombination	GO:0006310	92	0.026
rap protein signal transduction	GO:0032486	3	0.025
embryonic genitalia morphogenesis	GO:0030538	4	0.025
regulation of heart looping	GO:1901207	1	0.025
renal vesicle induction	GO:0072034	3	0.025
cytokine production	GO:0001816	319	0.025
olfactory bulb development	GO:0021772	30	0.025
cellular response to bmp stimulus	GO:0071773	14	0.025
canonical wnt signaling pathway	GO:0060070	130	0.025
negative regulation of cell proliferation involved in contact inhibition	GO:0060244	3	0.025
tissue regeneration	GO:0042246	22	0.025	Mouse
protein import	GO:0017038	101	0.025
t cell differentiation	GO:0030217	174	0.025
adult behavior	GO:0030534	135	0.025
negative regulation of cellular amine metabolic process	GO:0033239	1	0.025
circulatory system process	GO:0003013	197	0.025
regulation of dermatome development	GO:0061183	1	0.024
lateral line system development	GO:0048925	1	0.024
neuroblast proliferation	GO:0007405	49	0.024
cellular response to heparin	GO:0071504	1	0.024
specification of organ identity	GO:0010092	30	0.024
fasciculation of sensory neuron axon	GO:0097155	3	0.024
regulation of gliogenesis	GO:0014013	50	0.024
mitotic cell cycle	GO:0000278	195	0.024
male gonad development	GO:0008584	88	0.024
notochord cell development	GO:0060035	1	0.024
inflammatory response	GO:0006954	244	0.024
negative regulation of epithelial cell proliferation	GO:0050680	64	0.024

Capn6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.521
musculoskeletal system disease	DOID:17	0.521
connective tissue disease	DOID:65	0.091
bone development disease	DOID:0080006	0.064
bone disease	DOID:0080001	0.064
muscular disease	DOID:0080000	0.030
cardiovascular system disease	DOID:1287	0.024

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