IMP: Integrative Multi-species Prediction

Mus musculus

42 known processes

Xrcc1

X-ray repair complementing defective repair in Chinese hamster cells 1

(Aliases: MGC102556,Xrcc-1)

Entrez: 22594
Ensembl: ENSMUSG00000051768
UniProtKB: Q3TGI0
UniProtKB: Q60596

Process Predictions
Disease Predictions

Xrcc1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
ribonucleotide catabolic process	GO:0009261	208	0.182
regulation of antimicrobial humoral response	GO:0002759	3	0.102
nucleoside metabolic process	GO:0009116	246	0.095
nucleobase containing small molecule metabolic process	GO:0055086	352	0.089
chromatin organization	GO:0006325	206	0.087
heterocycle catabolic process	GO:0046700	280	0.077
organic cyclic compound catabolic process	GO:1901361	295	0.073
ras protein signal transduction	GO:0007265	77	0.073
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway	GO:0043162	3	0.070
aromatic compound catabolic process	GO:0019439	286	0.068
carbohydrate derivative catabolic process	GO:1901136	231	0.068
dna metabolic process	GO:0006259	303	0.067
cellular nitrogen compound catabolic process	GO:0044270	280	0.067
negative regulation of cell proliferation	GO:0008285	296	0.066
ribonucleotide metabolic process	GO:0009259	291	0.064
organonitrogen compound catabolic process	GO:1901565	264	0.063
cellular response to dna damage stimulus	GO:0006974	207	0.060
glycosyl compound metabolic process	GO:1901657	246	0.060
rna interference	GO:0016246	2	0.056
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.054
antimicrobial peptide production	GO:0002775	2	0.052
cellular amino acid metabolic process	GO:0006520	103	0.050
purine nucleoside metabolic process	GO:0042278	241	0.050
purine nucleoside catabolic process	GO:0006152	205	0.048
digestive tract development	GO:0048565	190	0.046
purine ribonucleoside catabolic process	GO:0046130	205	0.045
ribonucleoside catabolic process	GO:0042454	206	0.044
immune effector process	GO:0002252	321	0.044
regulation of multi organism process	GO:0043900	111	0.044
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.043
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.042
purine ribonucleoside metabolic process	GO:0046128	241	0.042
multi multicellular organism process	GO:0044706	109	0.039
nuclear division	GO:0000280	158	0.038
organophosphate catabolic process	GO:0046434	232	0.037
small gtpase mediated signal transduction	GO:0007264	97	0.036
nucleotide metabolic process	GO:0009117	332	0.036
nucleotide catabolic process	GO:0009166	217	0.035
nucleoside phosphate catabolic process	GO:1901292	222	0.035
response to acid chemical	GO:0001101	111	0.034
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.034
regulation of cell cycle	GO:0051726	281	0.034
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.034
purine ribonucleotide catabolic process	GO:0009154	208	0.034
nucleoside triphosphate catabolic process	GO:0009143	205	0.033
nucleoside catabolic process	GO:0009164	206	0.033
endocytosis	GO:0006897	168	0.032
gene silencing	GO:0016458	38	0.032
regulation of cell cycle process	GO:0010564	160	0.032
embryonic placenta development	GO:0001892	98	0.032
dna repair	GO:0006281	107	0.031
negative regulation of multi organism process	GO:0043901	68	0.031
nucleoside monophosphate metabolic process	GO:0009123	85	0.031
embryonic organ morphogenesis	GO:0048562	276	0.031
epidermis development	GO:0008544	187	0.030
glycosyl compound catabolic process	GO:1901658	206	0.029
posttranscriptional regulation of gene expression	GO:0010608	155	0.029
atp catabolic process	GO:0006200	55	0.029
innate immune response	GO:0045087	157	0.029
digestive system development	GO:0055123	200	0.029
camera type eye development	GO:0043010	266	0.028
purine containing compound metabolic process	GO:0072521	311	0.028
hatching	GO:0035188	4	0.028
chromatin modification	GO:0016568	187	0.028
posttranscriptional gene silencing by rna	GO:0035194	10	0.027
macromolecule catabolic process	GO:0009057	281	0.027
gene silencing by mirna	GO:0035195	10	0.027
negative regulation of cellular protein metabolic process	GO:0032269	247	0.027
metal ion homeostasis	GO:0055065	189	0.027
purine nucleotide catabolic process	GO:0006195	211	0.026
stem cell development	GO:0048864	219	0.026
positive regulation of cellular amine metabolic process	GO:0033240	5	0.026
cytokine production	GO:0001816	319	0.025
maintenance of apical basal cell polarity	GO:0035090	3	0.025
regulation of cell cycle phase transition	GO:1901987	77	0.025
viral transcription	GO:0019083	3	0.025
regulation of hydrolase activity	GO:0051336	246	0.025
stem cell differentiation	GO:0048863	268	0.024
purine containing compound catabolic process	GO:0072523	213	0.024
positive regulation of cell death	GO:0010942	224	0.024
ribose phosphate metabolic process	GO:0019693	291	0.024
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.024
cellular response to lipid	GO:0071396	145	0.024
organism emergence from protective structure	GO:0071684	4	0.024
negative regulation of molecular function	GO:0044092	258	0.023
cellular amine metabolic process	GO:0044106	44	0.023
skeletal system development	GO:0001501	356	0.023
multicellular organismal aging	GO:0010259	24	0.023
nucleoside phosphate metabolic process	GO:0006753	338	0.023
positive regulation of programmed cell death	GO:0043068	218	0.023
negative regulation of protein metabolic process	GO:0051248	282	0.023
covalent chromatin modification	GO:0016569	163	0.023
gene silencing by rna	GO:0031047	19	0.023
cellular ketone metabolic process	GO:0042180	84	0.022
protein localization to cell junction	GO:1902414	3	0.022
microtubule based process	GO:0007017	236	0.022
translation	GO:0006412	93	0.021
response to lipopolysaccharide	GO:0032496	128	0.021
regulation of antimicrobial peptide production	GO:0002784	1	0.020
maintenance of epithelial cell apical basal polarity	GO:0045199	2	0.020
response to molecule of bacterial origin	GO:0002237	143	0.020
protein catabolic process	GO:0030163	221	0.020
motor neuron migration	GO:0097475	4	0.020
mitotic cell cycle	GO:0000278	195	0.020
protein targeting	GO:0006605	143	0.020
proteasomal protein catabolic process	GO:0010498	98	0.020
regulation of response to biotic stimulus	GO:0002831	38	0.019
modification dependent macromolecule catabolic process	GO:0043632	133	0.019
b cell activation	GO:0042113	161	0.019
sensory organ morphogenesis	GO:0090596	242	0.019
regulation of mrna splicing via spliceosome	GO:0048024	32	0.019
antimicrobial peptide biosynthetic process	GO:0002777	2	0.019
male gamete generation	GO:0048232	285	0.018
regulation of binding	GO:0051098	111	0.018
cellular protein catabolic process	GO:0044257	155	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.018
intracellular receptor signaling pathway	GO:0030522	74	0.018
gland development	GO:0048732	330	0.018
interspecies interaction between organisms	GO:0044419	83	0.018
regulation of cytokine production	GO:0001817	266	0.018
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.018
rna processing	GO:0006396	105	0.018
nucleotide excision repair	GO:0006289	13	0.018
protein localization to adherens junction	GO:0071896	2	0.018
regulation of ras protein signal transduction	GO:0046578	114	0.018
calcium ion homeostasis	GO:0055074	127	0.017
single organism nuclear import	GO:1902593	95	0.017
cell cycle checkpoint	GO:0000075	47	0.017
regulation of organelle organization	GO:0033043	289	0.017
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.017
response to transforming growth factor beta	GO:0071559	88	0.017
dna dependent dna replication maintenance of fidelity	GO:0045005	3	0.017
intracellular protein transport	GO:0006886	204	0.017
meiotic nuclear division	GO:0007126	115	0.017
sensory perception	GO:0007600	245	0.017
viral gene expression	GO:0019080	3	0.017
skin development	GO:0043588	220	0.017
positive regulation of nucleotide catabolic process	GO:0030813	88	0.017
regulation of cellular ketone metabolic process	GO:0010565	66	0.016
response to organic cyclic compound	GO:0014070	198	0.016
demethylation	GO:0070988	23	0.016
gonad development	GO:0008406	141	0.016
organelle fission	GO:0048285	170	0.016
nucleoside monophosphate catabolic process	GO:0009125	59	0.016
nuclear import	GO:0051170	95	0.016
chemotaxis	GO:0006935	247	0.016
purine nucleotide metabolic process	GO:0006163	302	0.016
regulation of cell motility	GO:2000145	236	0.016
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.016
response to radiation	GO:0009314	165	0.015
striated muscle tissue development	GO:0014706	293	0.015
amine metabolic process	GO:0009308	45	0.015
histone deubiquitination	GO:0016578	2	0.015
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.015
regulation of nucleotide catabolic process	GO:0030811	122	0.015
metencephalon development	GO:0022037	89	0.015
protein localization to organelle	GO:0033365	185	0.015
epithelial tube formation	GO:0072175	130	0.015
development of primary sexual characteristics	GO:0045137	143	0.015
cation homeostasis	GO:0055080	212	0.015
locomotory behavior	GO:0007626	195	0.015
atp metabolic process	GO:0046034	75	0.015
nuclear transport	GO:0051169	139	0.015
positive regulation of gtpase activity	GO:0043547	85	0.015
neuron death	GO:0070997	154	0.015
cellular amide metabolic process	GO:0043603	58	0.015
tube closure	GO:0060606	91	0.014
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.014
cellular response to organic cyclic compound	GO:0071407	87	0.014
protein localization to nucleus	GO:0034504	121	0.014
spermatogenesis	GO:0007283	284	0.014
production of molecular mediator of immune response	GO:0002440	103	0.014
regulation of protein kinase activity	GO:0045859	232	0.014
ribonucleoside metabolic process	GO:0009119	245	0.014
posttranscriptional gene silencing	GO:0016441	10	0.014
peptide metabolic process	GO:0006518	46	0.014
protein modification by small protein conjugation or removal	GO:0070647	207	0.014
microtubule cytoskeleton organization	GO:0000226	157	0.014
dna templated transcription initiation	GO:0006352	13	0.014
nucleocytoplasmic transport	GO:0006913	139	0.014
digestive tract morphogenesis	GO:0048546	147	0.014
cell adhesion	GO:0007155	329	0.014
response to temperature stimulus	GO:0009266	55	0.014
regulation of cellular amino acid metabolic process	GO:0006521	5	0.014
dna recombination	GO:0006310	92	0.014
connective tissue development	GO:0061448	179	0.014
hindbrain development	GO:0030902	128	0.013
protein oligomerization	GO:0051259	67	0.013
receptor mediated endocytosis	GO:0006898	51	0.013
cellular homeostasis	GO:0019725	240	0.013
regulation of antimicrobial peptide biosynthetic process	GO:0002805	1	0.013
blastocyst development	GO:0001824	80	0.013
embryonic digestive tract development	GO:0048566	27	0.013
regulation of dna binding	GO:0051101	39	0.013
muscle cell differentiation	GO:0042692	261	0.013
organonitrogen compound biosynthetic process	GO:1901566	192	0.013
pharynx development	GO:0060465	1	0.013
viral life cycle	GO:0019058	36	0.013
positive regulation of protein modification process	GO:0031401	299	0.013
lipid homeostasis	GO:0055088	63	0.013
neural tube development	GO:0021915	160	0.013
histone lysine demethylation	GO:0070076	13	0.013
astrocyte cell migration	GO:0043615	3	0.013
homeostasis of number of cells	GO:0048872	210	0.013
epithelial tube morphogenesis	GO:0060562	303	0.013
apoptotic signaling pathway	GO:0097190	306	0.013
protein ubiquitination	GO:0016567	171	0.013
fat cell differentiation	GO:0045444	160	0.013
cellular response to acid chemical	GO:0071229	68	0.013
oocyte construction	GO:0007308	2	0.013
epithelial cell development	GO:0002064	159	0.013
response to light stimulus	GO:0009416	135	0.012
cellular ion homeostasis	GO:0006873	165	0.012
appendage development	GO:0048736	166	0.012
negative regulation of cell cycle process	GO:0010948	69	0.012
viral process	GO:0016032	41	0.012
response to oxidative stress	GO:0006979	123	0.012
establishment of tissue polarity	GO:0007164	28	0.012
skeletal muscle organ development	GO:0060538	163	0.012
negative regulation of cell cycle phase transition	GO:1901988	48	0.012
intrinsic apoptotic signaling pathway	GO:0097193	132	0.012
protein processing	GO:0016485	163	0.012
dna replication	GO:0006260	52	0.012
peptide transport	GO:0015833	133	0.012
histone modification	GO:0016570	159	0.012
muscle tissue development	GO:0060537	308	0.012
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.012
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.012
negative regulation of intracellular signal transduction	GO:1902532	167	0.012
cytoplasmic transport	GO:0016482	234	0.012
rna splicing via transesterification reactions	GO:0000375	43	0.012
positive regulation of microtubule polymerization or depolymerization	GO:0031112	3	0.012
dna biosynthetic process	GO:0071897	22	0.012
learning or memory	GO:0007611	148	0.012
establishment of planar polarity	GO:0001736	28	0.012
regulation of protein catabolic process	GO:0042176	108	0.012
vitamin d receptor signaling pathway	GO:0070561	2	0.012
mrna processing	GO:0006397	63	0.012
mammary gland epithelium development	GO:0061180	65	0.012
negative regulation of cytokine production	GO:0001818	84	0.012
purine ribonucleotide metabolic process	GO:0009150	290	0.011
stem cell maintenance	GO:0019827	130	0.011
inner ear receptor cell differentiation	GO:0060113	61	0.011
regulation of apoptotic signaling pathway	GO:2001233	197	0.011
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.011
intermediate filament based process	GO:0045103	27	0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.011
regionalization	GO:0003002	337	0.011
regulation of tumor necrosis factor production	GO:0032680	49	0.011
protein maturation	GO:0051604	176	0.011
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.011
cognition	GO:0050890	149	0.011
tube formation	GO:0035148	140	0.011
wound healing	GO:0042060	157	0.011
multicellular organism growth	GO:0035264	161	0.011
limb development	GO:0060173	166	0.011
maintenance of location	GO:0051235	89	0.011
negative regulation of mitotic cell cycle	GO:0045930	58	0.011
regulation of cellular amine metabolic process	GO:0033238	20	0.011
defense response to other organism	GO:0098542	197	0.011
negative regulation of binding	GO:0051100	39	0.011
regulation of proteolysis	GO:0030162	164	0.011
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.011
germ cell development	GO:0007281	185	0.011
auditory receptor cell differentiation	GO:0042491	37	0.011
urogenital system development	GO:0001655	261	0.011
regulation of viral transcription	GO:0046782	3	0.010
regulation of response to alcohol	GO:1901419	2	0.010
leukocyte differentiation	GO:0002521	342	0.010
gastrulation	GO:0007369	116	0.010
mitotic cell cycle process	GO:1903047	159	0.010
hematopoietic stem cell proliferation	GO:0071425	13	0.010
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.010
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.010
vesicle localization	GO:0051648	86	0.010
primary neural tube formation	GO:0014020	95	0.010
cardiocyte differentiation	GO:0035051	87	0.010
chromatin remodeling	GO:0006338	32	0.010
positive regulation of cytokine production	GO:0001819	174	0.010
regulation of neuron death	GO:1901214	134	0.010
negative regulation of protein processing	GO:0010955	79	0.010
positive regulation of apoptotic process	GO:0043065	217	0.010
regulation of hormone levels	GO:0010817	211	0.010
regulation of chromosome organization	GO:0033044	83	0.010

Xrcc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.039
nervous system disease	DOID:863	0.039
central nervous system disease	DOID:331	0.021
neurodegenerative disease	DOID:1289	0.018
disease of cellular proliferation	DOID:14566	0.016

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network