IMP: Integrative Multi-species Prediction

Mus musculus

33 known processes

Smc3

structural maintenace of chromosomes 3

(Aliases: HCAP,SMC-3,Mmip1,Bamacan,Cspg6,SmcD)

Entrez: 13006
Ensembl: ENSMUSG00000024974
UniProtKB: Q3TMK9
UniProtKB: Q1HL32
UniProtKB: Q9CW03

Process Predictions
Disease Predictions

Smc3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of dna endoreduplication	GO:0032875	3	0.995	Human
sister chromatid cohesion	GO:0007062	12	0.990	Human Yeast Zebrafish
negative regulation of dna dependent dna replication	GO:2000104	1	0.983	Human
dna repair	GO:0006281	107	0.971	Yeast
meiotic cell cycle process	GO:1903046	77	0.929	Yeast
negative regulation of dna replication	GO:0008156	4	0.896	Human
chromosome organization involved in meiosis	GO:0070192	39	0.865	Yeast
meiotic cell cycle	GO:0051321	122	0.864
meiotic nuclear division	GO:0007126	115	0.856
synapsis	GO:0007129	34	0.851	Yeast
histone methylation	GO:0016571	71	0.846
dna metabolic process	GO:0006259	303	0.843	Human Yeast
histone modification	GO:0016570	159	0.838
protein methylation	GO:0006479	81	0.828
chromatin assembly or disassembly	GO:0006333	16	0.815
protein alkylation	GO:0008213	81	0.812
heterochromatin organization	GO:0070828	4	0.803
regulation of chromatin modification	GO:1903308	57	0.739
development of primary sexual characteristics	GO:0045137	143	0.731
double strand break repair	GO:0006302	48	0.729	Yeast
response to ionizing radiation	GO:0010212	42	0.717
mitotic sister chromatid cohesion	GO:0007064	1	0.713	Yeast Zebrafish
stem cell maintenance	GO:0019827	130	0.709
regulation of cell cycle	GO:0051726	281	0.677	Human
dna replication	GO:0006260	52	0.650	Human
genetic imprinting	GO:0071514	27	0.649
spermatogenesis	GO:0007283	284	0.649
chromatin modification	GO:0016568	187	0.596
gonad development	GO:0008406	141	0.585
organelle fission	GO:0048285	170	0.575
dna replication independent nucleosome assembly	GO:0006336	1	0.572
dna endoreduplication	GO:0042023	4	0.566	Human
peptidyl lysine modification	GO:0018205	77	0.551
seminiferous tubule development	GO:0072520	14	0.530
regulation of dna replication	GO:0006275	17	0.522	Human
covalent chromatin modification	GO:0016569	163	0.489
dna conformation change	GO:0071103	37	0.487
developmental maturation	GO:0021700	193	0.481
negative regulation of gene expression epigenetic	GO:0045814	15	0.467
methylation	GO:0032259	134	0.458
negative regulation of histone methylation	GO:0031061	10	0.458
macromolecule methylation	GO:0043414	120	0.457
stem cell differentiation	GO:0048863	268	0.452
gene silencing	GO:0016458	38	0.446
dendrite development	GO:0016358	115	0.417
proprioception	GO:0019230	4	0.416
mitotic sister chromatid segregation	GO:0000070	14	0.406	Yeast Zebrafish
cellular response to dna damage stimulus	GO:0006974	207	0.401	Yeast
dna dependent dna replication maintenance of fidelity	GO:0045005	3	0.398
ventricular system development	GO:0021591	27	0.384
mitotic cell cycle process	GO:1903047	159	0.380	Human Yeast Zebrafish
regulation of cellular amino acid metabolic process	GO:0006521	5	0.373
regulation of chromatin organization	GO:1902275	57	0.366
neuron maturation	GO:0042551	29	0.365
mitotic cell cycle	GO:0000278	195	0.361	Human Yeast Zebrafish
nuclear division	GO:0000280	158	0.358
response to x ray	GO:0010165	11	0.340
cellular ketone metabolic process	GO:0042180	84	0.337
meiotic chromosome segregation	GO:0045132	19	0.335	Yeast
chromatin organization	GO:0006325	206	0.316
regulation of cellular amine metabolic process	GO:0033238	20	0.294
negative regulation of cell cycle	GO:0045786	123	0.287	Human
male sex differentiation	GO:0046661	109	0.282
male gamete generation	GO:0048232	285	0.278
cellular amine metabolic process	GO:0044106	44	0.278
regulation of nuclear cell cycle dna replication	GO:0033262	2	0.245
nucleoside monophosphate metabolic process	GO:0009123	85	0.243
response to radiation	GO:0009314	165	0.226
regulation of chromosome organization	GO:0033044	83	0.224
cell cycle checkpoint	GO:0000075	47	0.212
chromatin silencing	GO:0006342	15	0.209
dna dependent dna replication	GO:0006261	24	0.204	Human
genitalia development	GO:0048806	37	0.201
positive regulation of chromosome organization	GO:2001252	33	0.198
cellular amino acid metabolic process	GO:0006520	103	0.196
regulation of histone modification	GO:0031056	56	0.194
regulation of protein acetylation	GO:1901983	22	0.193
response to light stimulus	GO:0009416	135	0.184
meiosis i	GO:0007127	60	0.172	Yeast
regulation of transcription by chromatin organization	GO:0034401	0	0.170
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.163
protein dna complex subunit organization	GO:0071824	28	0.155
positive regulation of cellular amine metabolic process	GO:0033240	5	0.147
chromosome segregation	GO:0007059	48	0.146	Human Yeast Zebrafish
regulation of mitotic cell cycle	GO:0007346	126	0.142
glycerophospholipid metabolic process	GO:0006650	71	0.139
spermatid differentiation	GO:0048515	115	0.138
cell maturation	GO:0048469	127	0.137
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.136
regulation of cellular ketone metabolic process	GO:0010565	66	0.136
regulation of peptidyl lysine acetylation	GO:2000756	22	0.135
negative regulation of cell cycle process	GO:0010948	69	0.131	Human
peptidyl amino acid modification	GO:0018193	336	0.129
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.126
sister chromatid segregation	GO:0000819	20	0.124	Yeast Zebrafish
regulation of cell cycle process	GO:0010564	160	0.122	Human
negative regulation of chromosome organization	GO:2001251	30	0.119
stem cell development	GO:0048864	219	0.117
dna packaging	GO:0006323	30	0.115
meiotic sister chromatid cohesion	GO:0051177	6	0.111	Yeast
response to uv	GO:0009411	44	0.110
protein acylation	GO:0043543	64	0.106
endocytosis	GO:0006897	168	0.102
membrane depolarization	GO:0051899	64	0.100
dna recombination	GO:0006310	92	0.095	Yeast
regulation of organelle organization	GO:0033043	289	0.094
internal peptidyl lysine acetylation	GO:0018393	42	0.093
negative regulation of cellular amine metabolic process	GO:0033239	1	0.093
mitotic cell cycle checkpoint	GO:0007093	31	0.090
mitotic nuclear division	GO:0007067	48	0.088	Yeast Zebrafish
dna methylation involved in gamete generation	GO:0043046	15	0.087
ribose phosphate metabolic process	GO:0019693	291	0.086
regulation of histone acetylation	GO:0035065	19	0.085
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.083
signal transduction by p53 class mediator	GO:0072331	51	0.081
nucleotide metabolic process	GO:0009117	332	0.080
meiotic sister chromatid segregation	GO:0045144	6	0.080	Yeast
amine metabolic process	GO:0009308	45	0.080
negative regulation of mitotic cell cycle	GO:0045930	58	0.077
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.077
histone acetylation	GO:0016573	41	0.074
purine nucleotide catabolic process	GO:0006195	211	0.073
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.071
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.068
peptidyl lysine acetylation	GO:0018394	45	0.067
replication fork processing	GO:0031297	1	0.065
apoptotic signaling pathway	GO:0097190	306	0.065
glycosyl compound metabolic process	GO:1901657	246	0.063
regulation of histone methylation	GO:0031060	30	0.063
neuron projection guidance	GO:0097485	141	0.061
nucleobase containing small molecule metabolic process	GO:0055086	352	0.060
protein localization to organelle	GO:0033365	185	0.058
development of primary male sexual characteristics	GO:0046546	88	0.058
male meiosis	GO:0007140	37	0.058
ribonucleotide catabolic process	GO:0009261	208	0.058
fertilization	GO:0009566	127	0.056
adult behavior	GO:0030534	135	0.054
cellular biogenic amine metabolic process	GO:0006576	28	0.053
neuron apoptotic process	GO:0051402	142	0.052
cellular respiration	GO:0045333	38	0.050
alcohol metabolic process	GO:0006066	116	0.049
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.049
negative regulation of cell cycle phase transition	GO:1901988	48	0.049
negative regulation of cellular component organization	GO:0051129	194	0.048
axon guidance	GO:0007411	141	0.048
intraspecies interaction between organisms	GO:0051703	21	0.047
glial cell migration	GO:0008347	7	0.046
regulation of chromatin silencing	GO:0031935	2	0.046
axonogenesis	GO:0007409	274	0.044
positive regulation of cellular component biogenesis	GO:0044089	94	0.044
telomere maintenance	GO:0000723	19	0.043
ribonucleoside metabolic process	GO:0009119	245	0.043
regulation of neuron death	GO:1901214	134	0.042
glutamine metabolic process	GO:0006541	8	0.042
nuclear dna replication	GO:0033260	3	0.042
internal protein amino acid acetylation	GO:0006475	42	0.041
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.041
histone lysine methylation	GO:0034968	50	0.041
neuromuscular process controlling posture	GO:0050884	14	0.041
receptor mediated endocytosis	GO:0006898	51	0.041
positive regulation of histone methylation	GO:0031062	16	0.041
blastocyst development	GO:0001824	80	0.041
visual learning	GO:0008542	44	0.040
negative regulation of chromatin modification	GO:1903309	19	0.040
mapk cascade	GO:0000165	281	0.040
male gonad development	GO:0008584	88	0.040
visual behavior	GO:0007632	45	0.039
positive regulation of organelle organization	GO:0010638	128	0.038
organophosphate catabolic process	GO:0046434	232	0.038
regulation of membrane potential	GO:0042391	192	0.036
anatomical structure homeostasis	GO:0060249	145	0.035
chemotaxis	GO:0006935	247	0.034
epithelial cell development	GO:0002064	159	0.034
regulation of gene expression by genetic imprinting	GO:0006349	15	0.034
nitrogen compound transport	GO:0071705	271	0.034
cell type specific apoptotic process	GO:0097285	268	0.033
organelle localization	GO:0051640	179	0.033
regulation of cell cycle phase transition	GO:1901987	77	0.033
response to oxygen levels	GO:0070482	62	0.033
positive regulation of chromatin modification	GO:1903310	28	0.031
organic hydroxy compound metabolic process	GO:1901615	203	0.031
positive regulation of nuclear cell cycle dna replication	GO:0010571	1	0.030
organic cyclic compound catabolic process	GO:1901361	295	0.030
dna damage response signal transduction by p53 class mediator	GO:0030330	19	0.030
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.029
positive regulation of cell cycle process	GO:0090068	61	0.029
cerebellum development	GO:0021549	77	0.029
purine ribonucleotide metabolic process	GO:0009150	290	0.029
glutamine family amino acid metabolic process	GO:0009064	15	0.028
chromatin remodeling	GO:0006338	32	0.028
learning	GO:0007612	98	0.027
positive regulation of histone modification	GO:0031058	28	0.027
negative regulation of neuron death	GO:1901215	98	0.027
dna alkylation	GO:0006305	43	0.027
oxidation reduction process	GO:0055114	342	0.026
locomotory behavior	GO:0007626	195	0.026
cellular response to organonitrogen compound	GO:0071417	145	0.026
response to decreased oxygen levels	GO:0036293	59	0.026
forebrain development	GO:0030900	302	0.025
negative regulation of protein modification process	GO:0031400	163	0.025
aromatic compound catabolic process	GO:0019439	286	0.025
signal transduction in response to dna damage	GO:0042770	21	0.024
social behavior	GO:0035176	21	0.023
heterochromatin assembly	GO:0031507	2	0.022
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.022
double strand break repair via homologous recombination	GO:0000724	21	0.022	Yeast
nucleoside triphosphate catabolic process	GO:0009143	205	0.022
regulation of respiratory system process	GO:0044065	13	0.021
defense response to other organism	GO:0098542	197	0.021
nucleoside phosphate catabolic process	GO:1901292	222	0.021
purine containing compound metabolic process	GO:0072521	311	0.021
response to hypoxia	GO:0001666	58	0.021
glycerolipid metabolic process	GO:0046486	122	0.021
microtubule based process	GO:0007017	236	0.021	Human
intra s dna damage checkpoint	GO:0031573	4	0.021
positive regulation of homeostatic process	GO:0032846	64	0.020
nucleoside metabolic process	GO:0009116	246	0.020
regulation of respiratory gaseous exchange by neurological system process	GO:0002087	12	0.019
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.019
nucleoside phosphate metabolic process	GO:0006753	338	0.019
phospholipid metabolic process	GO:0006644	87	0.019
neuron death	GO:0070997	154	0.019
positive regulation of synapse assembly	GO:0051965	18	0.019
purine nucleotide metabolic process	GO:0006163	302	0.019
establishment of organelle localization	GO:0051656	122	0.018
heterochromatin organization involved in chromatin silencing	GO:0070868	1	0.018
microtubule nucleation	GO:0007020	2	0.018
chromatin assembly	GO:0031497	13	0.018
carbohydrate derivative catabolic process	GO:1901136	231	0.017
nucleic acid phosphodiester bond hydrolysis	GO:0090305	49	0.017
rna processing	GO:0006396	105	0.017
regulation of respiratory gaseous exchange	GO:0043576	18	0.017
nucleoside triphosphate metabolic process	GO:0009141	230	0.017
ribonucleoside catabolic process	GO:0042454	206	0.016
cognition	GO:0050890	149	0.016
histone h3 k4 methylation	GO:0051568	23	0.016
regulation of binding	GO:0051098	111	0.016
regulation of cytoplasmic transport	GO:1903649	112	0.016
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.016
regulation of cellular component biogenesis	GO:0044087	181	0.016
cellular lipid metabolic process	GO:0044255	323	0.016
adult locomotory behavior	GO:0008344	91	0.016
germ cell development	GO:0007281	185	0.016
neuromuscular process	GO:0050905	99	0.015
cellular macromolecule catabolic process	GO:0044265	206	0.015
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	18	0.015
purine nucleoside metabolic process	GO:0042278	241	0.015
multicellular organism growth	GO:0035264	161	0.015
histone h3 k9 dimethylation	GO:0036123	4	0.015
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.015
regulation of intracellular transport	GO:0032386	159	0.015
nucleotide catabolic process	GO:0009166	217	0.015
lymphocyte differentiation	GO:0030098	242	0.014
protein modification by small protein conjugation or removal	GO:0070647	207	0.014
negative regulation of cellular protein metabolic process	GO:0032269	247	0.014
regulation of neuron projection development	GO:0010975	169	0.014
spermatid development	GO:0007286	108	0.014
heterocycle catabolic process	GO:0046700	280	0.014
mitotic chromosome condensation	GO:0007076	1	0.014
positive regulation of binding	GO:0051099	49	0.014
protein modification by small protein removal	GO:0070646	21	0.014
negative regulation of synapse assembly	GO:0051964	3	0.014
somatic cell dna recombination	GO:0016444	51	0.014
respiratory gaseous exchange	GO:0007585	43	0.014
ribonucleotide metabolic process	GO:0009259	291	0.013
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.013
leukocyte differentiation	GO:0002521	342	0.013
regulation of dna dependent dna replication	GO:0090329	8	0.013	Human
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.013
intracellular mrna localization	GO:0008298	4	0.013
chromatin mediated maintenance of transcription	GO:0048096	2	0.013
purine nucleoside catabolic process	GO:0006152	205	0.013
cellular response to inorganic substance	GO:0071241	37	0.013
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.013
positive regulation of nervous system development	GO:0051962	221	0.012
phosphatidylcholine metabolic process	GO:0046470	13	0.012
generation of precursor metabolites and energy	GO:0006091	103	0.012
negative regulation of cell proliferation	GO:0008285	296	0.012
cellular response to organic cyclic compound	GO:0071407	87	0.012
insulin receptor signaling pathway	GO:0008286	49	0.012
cellular response to hormone stimulus	GO:0032870	150	0.012
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.012
negative regulation of neuron apoptotic process	GO:0043524	92	0.012
atp metabolic process	GO:0046034	75	0.012
positive regulation of protein phosphorylation	GO:0001934	242	0.012
catecholamine secretion	GO:0050432	15	0.012
nuclear transport	GO:0051169	139	0.011
synapse assembly	GO:0007416	56	0.011
negative regulation of histone acetylation	GO:0035067	7	0.011
nucleosome assembly	GO:0006334	7	0.011
long term synaptic potentiation	GO:0060291	25	0.011
peptidyl lysine methylation	GO:0018022	29	0.011
protein maturation	GO:0051604	176	0.011
associative learning	GO:0008306	61	0.011
polyol metabolic process	GO:0019751	26	0.011
ncrna processing	GO:0034470	26	0.011
regionalization	GO:0003002	337	0.011
nucleocytoplasmic transport	GO:0006913	139	0.011
cardiolipin metabolic process	GO:0032048	3	0.011
regulation of protein targeting	GO:1903533	61	0.011
organic hydroxy compound transport	GO:0015850	93	0.011
protein targeting	GO:0006605	143	0.011
response to inorganic substance	GO:0010035	96	0.011
establishment of protein localization to organelle	GO:0072594	118	0.011
regulation of cellular response to stress	GO:0080135	159	0.011
atp catabolic process	GO:0006200	55	0.011
rna interference	GO:0016246	2	0.011
sensory perception	GO:0007600	245	0.011
mitotic recombination	GO:0006312	3	0.011
endomembrane system organization	GO:0010256	147	0.010
negative regulation of cellular catabolic process	GO:0031330	47	0.010
carbohydrate metabolic process	GO:0005975	230	0.010
female gamete generation	GO:0007292	74	0.010
regulation of lymphocyte activation	GO:0051249	240	0.010
adaptive immune response	GO:0002250	155	0.010
erk1 and erk2 cascade	GO:0070371	77	0.010

Smc3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
cornelia de lange syndrome	DOID:11725	0.910	Human
developmental disorder of mental health	DOID:0060037	0.058
autism spectrum disorder	DOID:0060041	0.058
pervasive developmental disorder	DOID:0060040	0.058
disease of mental health	DOID:150	0.058
central nervous system disease	DOID:331	0.038
disease of anatomical entity	DOID:7	0.038
nervous system disease	DOID:863	0.038
autistic disorder	DOID:12849	0.036
neurodegenerative disease	DOID:1289	0.026
physical disorder	DOID:0080015	0.011

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