Mus musculus

42 known processes

Smc4

structural maintenance of chromosomes 4

(Aliases: SMC-4,Smc4l1,C79747,2500002A22Rik)

Smc4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna conformation changeGO:0071103370.923
meiotic cell cycleGO:00513211220.895
dna metabolic processGO:00062593030.884
meiosis iGO:0007127600.768
microtubule cytoskeleton organizationGO:00002261570.722
mitotic cell cycleGO:00002781950.641
Human Worm
mitotic cytokinesisGO:000028140.638
microtubule based processGO:00070172360.634
regulation of microtubule based processGO:0032886520.536
female meiotic divisionGO:0007143210.426
regulation of microtubule cytoskeleton organizationGO:0070507370.408
microtubule organizing center organizationGO:0031023280.397
meiotic cell cycle processGO:1903046770.374
regulation of protein complex disassemblyGO:0043244280.358
cellular response to dna damage stimulusGO:00069742070.354
male gamete generationGO:00482322850.349
dna replicationGO:0006260520.348
cell divisionGO:00513011200.324
regulation of cell cycleGO:00517262810.319
spindle assembly involved in meiosisGO:009030640.304
regulation of cell cycle processGO:00105641600.287
dna packagingGO:0006323300.279
chromosome segregationGO:0007059480.272
organelle assemblyGO:00709251770.250
ubiquitin dependent protein catabolic processGO:00065111290.248
regulation of centriole replicationGO:004659910.231
mitotic spindle organizationGO:0007052100.225
dna repairGO:00062811070.212
microtubule polymerization or depolymerizationGO:0031109260.210
spindle assembly involved in female meiosis iGO:000705720.208
chromatin organizationGO:00063252060.200
regulation of mitotic cell cycleGO:00073461260.194
cellular macromolecule catabolic processGO:00442652060.193
protein catabolic processGO:00301632210.190
regulation of organelle organizationGO:00330432890.186
negative regulation of protein complex disassemblyGO:0043242220.184
purine ribonucleoside metabolic processGO:00461282410.178
mitotic cell cycle processGO:19030471590.176
Human Worm
establishment of organelle localizationGO:00516561220.176
negative regulation of cellular component organizationGO:00511291940.173
development of primary sexual characteristicsGO:00451371430.171
Worm
regulation of protein maturationGO:1903317960.167
positive regulation of hydrolase activityGO:00513451480.163
chromosome organization involved in meiosisGO:0070192390.162
cellular nitrogen compound catabolic processGO:00442702800.157
negative regulation of microtubule polymerization or depolymerizationGO:0031111150.153
mitotic sister chromatid segregationGO:0000070140.152
Human Worm
spermatid differentiationGO:00485151150.151
regulation of transferase activityGO:00513382630.144
negative regulation of cellular protein metabolic processGO:00322692470.142
centromere complex assemblyGO:003450830.138
regulation of spindle organizationGO:009022420.137
mitotic nuclear divisionGO:0007067480.131
Human Worm
spermatogenesisGO:00072832840.131
attachment of spindle microtubules to kinetochoreGO:000860840.127
negative regulation of microtubule depolymerizationGO:0007026130.126
regulation of hydrolase activityGO:00513362460.122
small gtpase mediated signal transductionGO:0007264970.118
intracellular protein transportGO:00068862040.113
negative regulation of cell cycleGO:00457861230.111
regulation of kinase activityGO:00435492490.111
sister chromatid segregationGO:0000819200.110
Human Worm
cytokinesisGO:0000910170.109
regulation of cytoskeleton organizationGO:00514931220.106
meiotic chromosome segregationGO:0045132190.103
positive regulation of gtp catabolic processGO:0033126850.103
regulation of cellular catabolic processGO:00313292420.101
positive regulation of gtpase activityGO:0043547850.101
ras protein signal transductionGO:0007265770.100
regulation of chromosome organizationGO:0033044830.095
negative regulation of protein depolymerizationGO:1901880210.093
negative regulation of chromosome organizationGO:2001251300.091
meiotic chromosome condensationGO:001003230.090
regulation of dna replicationGO:0006275170.090
positive regulation of protein modification processGO:00314012990.090
mitotic recombinationGO:000631230.089
positive regulation of kinase activityGO:00336741550.086
purine ribonucleoside triphosphate metabolic processGO:00092052200.084
muscle adaptationGO:0043500390.079
centrosome duplicationGO:0051298160.077
centrosome cycleGO:0007098230.077
regulation of protein depolymerizationGO:1901879260.077
cellular protein catabolic processGO:00442571550.077
protein depolymerizationGO:0051261340.077
protein maturationGO:00516041760.076
centrosome organizationGO:0051297260.075
germ cell developmentGO:00072811850.074
organelle fissionGO:00482851700.074
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.072
regulation of nucleotide metabolic processGO:00061401690.071
gtp metabolic processGO:00460391440.070
protein localization to organelleGO:00333651850.070
protein localization to nucleusGO:00345041210.069
negative regulation of meiotic cell cycleGO:0051447140.069
macromolecule catabolic processGO:00090572810.069
chromatin modificationGO:00165681870.068
ribonucleoside triphosphate catabolic processGO:00092031990.067
cellular protein complex disassemblyGO:0043624360.067
spindle assemblyGO:0051225130.064
spermatid developmentGO:00072861080.064
spindle assembly involved in mitosisGO:009030740.063
maintenance of locationGO:0051235890.060
meiotic nuclear divisionGO:00071261150.060
cell cycle checkpointGO:0000075470.058
mitotic chromosome condensationGO:000707610.058
Human
purine nucleoside metabolic processGO:00422782410.058
chromatin remodeling at centromereGO:003105520.057
negative regulation of organelle organizationGO:0010639900.057
regulation of microtubule depolymerizationGO:0031114130.057
regulation of neuron projection developmentGO:00109751690.057
purine nucleoside triphosphate metabolic processGO:00091442260.056
regulation of cellular response to stressGO:00801351590.056
modification dependent protein catabolic processGO:00199411330.056
dna alkylationGO:0006305430.055
regulation of microtubule polymerization or depolymerizationGO:0031110200.055
organophosphate catabolic processGO:00464342320.054
nucleotide catabolic processGO:00091662170.053
heterocycle catabolic processGO:00467002800.053
spindle assembly involved in female meiosisGO:000705630.053
spindle organizationGO:0007051280.052
carbohydrate derivative catabolic processGO:19011362310.051
ribose phosphate metabolic processGO:00196932910.051
dna ligationGO:000626630.051
organic cyclic compound catabolic processGO:19013612950.051
regulation of proteasomal protein catabolic processGO:0061136460.050
positive regulation of protein phosphorylationGO:00019342420.050
macromolecular complex disassemblyGO:0032984430.050
purine ribonucleotide metabolic processGO:00091502900.049
aromatic compound catabolic processGO:00194392860.049
neuron migrationGO:00017641220.049
protein complex disassemblyGO:0043241400.049
synapsisGO:0007129340.048
purine nucleoside triphosphate catabolic processGO:00091462030.047
regulation of nucleoside metabolic processGO:00091181300.047
regulation of cell cycle phase transitionGO:1901987770.047
purine ribonucleotide catabolic processGO:00091542080.047
nucleoside catabolic processGO:00091642060.046
protein dna complex subunit organizationGO:0071824280.046
regulation of systemic arterial blood pressure by vasopressinGO:000199230.045
neuron deathGO:00709971540.045
positive regulation of purine nucleotide metabolic processGO:19005441140.043
response to oxidative stressGO:00069791230.043
regulation of protein kinase activityGO:00458592320.043
regulation of mitotic cell cycle phase transitionGO:1901990730.043
circadian regulation of gene expressionGO:0032922480.043
nuclear transportGO:00511691390.042
purine ribonucleoside catabolic processGO:00461302050.041
nucleotide metabolic processGO:00091173320.041
regulation of cell divisionGO:0051302760.041
negative regulation of proteolysisGO:0045861740.040
ribonucleoside triphosphate metabolic processGO:00091992200.040
ribonucleotide catabolic processGO:00092612080.040
erythrocyte differentiationGO:0030218880.040
regulation of ras gtpase activityGO:0032318880.039
positive regulation of nucleotide metabolic processGO:00459811140.039
nucleoside phosphate metabolic processGO:00067533380.038
rho protein signal transductionGO:0007266320.038
negative regulation of molecular functionGO:00440922580.038
negative regulation of nuclear divisionGO:0051784190.038
positive regulation of cell cycle processGO:0090068610.038
mitotic cell cycle checkpointGO:0007093310.038
purine nucleotide catabolic processGO:00061952110.038
regulation of cell projection organizationGO:00313442060.037
regulation of purine nucleotide metabolic processGO:19005421690.037
nucleoside phosphate catabolic processGO:19012922220.036
nucleoside triphosphate catabolic processGO:00091432050.036
regulation of meiosis iGO:006063170.036
positive regulation of transferase activityGO:00513471670.036
negative regulation of protein maturationGO:1903318790.036
positive regulation of nucleoside metabolic processGO:0045979910.035
kinetochore organizationGO:005138320.035
female meiosis iGO:000714470.035
positive regulation of protein kinase activityGO:00458601440.035
positive regulation of cell cycleGO:0045787920.035
response to inactivityGO:001485440.035
cellular response to oxidative stressGO:0034599760.034
purine containing compound metabolic processGO:00725213110.034
regulation of cell activationGO:00508652890.034
negative regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032435150.033
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051220.033
modification dependent macromolecule catabolic processGO:00436321330.032
negative regulation of cellular protein catabolic processGO:1903363220.032
dna recombinationGO:0006310920.031
positive regulation of nucleotide catabolic processGO:0030813880.031
blastocyst developmentGO:0001824800.030
dendrite developmentGO:00163581150.029
Worm
regulation of rna splicingGO:0043484370.029
purine nucleotide metabolic processGO:00061633020.029
nucleobase containing small molecule metabolic processGO:00550863520.029
organelle localizationGO:00516401790.029
negative regulation of cytoskeleton organizationGO:0051494360.029
nucleocytoplasmic transportGO:00069131390.029
guanosine containing compound metabolic processGO:19010681440.029
endocytosisGO:00068971680.029
ribonucleoside catabolic processGO:00424542060.028
apoptotic signaling pathwayGO:00971903060.028
regulation of intracellular transportGO:00323861590.028
positive regulation of purine nucleotide catabolic processGO:0033123880.028
positive regulation of protein import into nucleusGO:0042307260.028
regulation of nucleocytoplasmic transportGO:0046822730.028
regulation of nuclear divisionGO:0051783560.027
axonogenesisGO:00074092740.027
negative regulation of protein processingGO:0010955790.027
negative regulation of cellular catabolic processGO:0031330470.027
regulation of purine nucleotide catabolic processGO:00331211220.027
rna interferenceGO:001624620.027
nuclear divisionGO:00002801580.027
regulation of ras protein signal transductionGO:00465781140.026
homeostasis of number of cellsGO:00488722100.026
actin cytoskeleton organizationGO:00300362200.026
lymphocyte differentiationGO:00300982420.026
male meiosisGO:0007140370.026
body morphogenesisGO:0010171450.025
Worm
negative regulation of cell cycle processGO:0010948690.025
regulation of neuron deathGO:19012141340.025
non recombinational repairGO:0000726100.025
peptidyl amino acid modificationGO:00181933360.025
neuron apoptotic processGO:00514021420.025
microtubule depolymerizationGO:0007019150.025
nucleus localizationGO:0051647200.025
histone mrna metabolic processGO:000833430.025
mitotic spindle assembly checkpointGO:000709470.024
regulation of proteolysisGO:00301621640.024
regulation of system processGO:00440572000.024
ribonucleotide metabolic processGO:00092592910.024
generation of precursor metabolites and energyGO:00060911030.024
regulation of wnt signaling pathwayGO:00301111230.024
spindle checkpointGO:0031577120.024
base excision repairGO:000628490.024
regulation of protein localizationGO:00328802310.023
positive regulation of nucleocytoplasmic transportGO:0046824300.023
negative regulation of multi organism processGO:0043901680.023
posttranscriptional regulation of gene expressionGO:00106081550.023
purine containing compound catabolic processGO:00725232130.023
retina development in camera type eyeGO:00600411190.023
response to radiationGO:00093141650.022
meiotic cytokinesisGO:003320650.022
nucleic acid phosphodiester bond hydrolysisGO:0090305490.022
cellular ketone metabolic processGO:0042180840.022
regulation of protein processingGO:0070613960.022
protein processingGO:00164851630.022
rna processingGO:00063961050.022
rna dependent dna replicationGO:000627830.021
positive regulation of mitotic cell cycleGO:0045931410.021
sister chromatid cohesionGO:0007062120.021
cellular response to metal ionGO:0071248310.021
dna replication independent nucleosome assemblyGO:000633610.021
regulation of cellular component biogenesisGO:00440871810.021
regulation of cytokinesisGO:003246550.021
digestive tract morphogenesisGO:00485461470.021
cellular protein complex assemblyGO:00436231160.021
neural precursor cell proliferationGO:00613511210.021
negative regulation of sister chromatid segregationGO:003304670.020
mrna 3 end processingGO:0031124160.020
positive regulation of protein serine threonine kinase activityGO:00719021060.020
positive regulation of cytoskeleton organizationGO:0051495490.020
regulation of chromosome segregationGO:0051983210.020
regulation of dna dependent dna replicationGO:009032980.020
positive regulation of cell cycle g1 s phase transitionGO:190280890.020
regulation of cell morphogenesis involved in differentiationGO:00107691510.020
negative regulation of intracellular signal transductionGO:19025321670.020
definitive hemopoiesisGO:0060216200.020
cellular response to lipidGO:00713961450.019
response to decreased oxygen levelsGO:0036293590.019
regulation of double strand break repair via nonhomologous end joiningGO:200103220.019
gene silencing by rnaGO:0031047190.019
activation of rac gtpase activityGO:003286320.019
regulation of dna endoreduplicationGO:003287530.019
regulation of cell shapeGO:0008360390.019
meiotic spindle organizationGO:000021290.019
cell type specific apoptotic processGO:00972852680.019
purine nucleoside catabolic processGO:00061522050.019
regulation of mitosisGO:0007088290.019
cdc42 protein signal transductionGO:003248800.019
microtubule cytoskeleton organization involved in mitosisGO:190285040.019
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.019
microtubule based movementGO:0007018840.019
response to growth factorGO:00708481980.018
regulation of protein serine threonine kinase activityGO:00719001570.018
cellular amino acid metabolic processGO:00065201030.018
cellular response to inorganic substanceGO:0071241370.018
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.018
cellular response to organic cyclic compoundGO:0071407870.017
negative regulation of protein metabolic processGO:00512482820.017
nucleoside triphosphate metabolic processGO:00091412300.017
regulation of myeloid cell differentiationGO:0045637960.017
glycosyl compound catabolic processGO:19016582060.017
negative regulation of neuron deathGO:1901215980.017
protein modification by small protein conjugation or removalGO:00706472070.017
regulation of apoptotic signaling pathwayGO:20012331970.016
glycosyl compound metabolic processGO:19016572460.016
chromatin assembly or disassemblyGO:0006333160.016
nucleobase containing compound transportGO:0015931270.016
negative regulation of chromatin silencingGO:003193610.016
single organism nuclear importGO:1902593950.016
response to ionizing radiationGO:0010212420.016
double strand break repair via homologous recombinationGO:0000724210.015
response to oxygen levelsGO:0070482620.015
protein import into nucleusGO:0006606950.015
myeloid cell homeostasisGO:00022621140.015
innate immune responseGO:00450871570.015
hematopoietic progenitor cell differentiationGO:00022441430.015
rna localizationGO:0006403230.015
megakaryocyte differentiationGO:0030219260.015
ossificationGO:00015032160.014
regulation of circadian rhythmGO:0042752580.014
nuclear importGO:0051170950.014
adult behaviorGO:00305341350.014
negative regulation of meiotic cell cycle phase transitionGO:190199430.014
receptor mediated endocytosisGO:0006898510.014
regulation of response to dna damage stimulusGO:2001020340.014
negative regulation of metaphase anaphase transition of cell cycleGO:190210080.014
negative regulation of mitotic sister chromatid segregationGO:003304870.014
entry into hostGO:0044409150.014
protein modification by small protein removalGO:0070646210.014
positive regulation of organelle organizationGO:00106381280.014
chromatin assemblyGO:0031497130.014
regulation of lymphocyte activationGO:00512492400.014
regulation of chromatin modificationGO:1903308570.014
positive regulation of nervous system developmentGO:00519622210.014
regulation of multi organism processGO:00439001110.013
regulation of bindingGO:00510981110.013
posttranscriptional gene silencingGO:0016441100.013
positive regulation of myeloid cell differentiationGO:0045639430.013
female gamete generationGO:0007292740.013
histone modificationGO:00165701590.013
ribonucleoprotein complex localizationGO:007116610.013
negative regulation of protein catabolic processGO:0042177360.013
protein importGO:00170381010.013
response to inorganic substanceGO:0010035960.013
negative regulation of viral processGO:0048525230.013
regulation of mapk cascadeGO:00434082480.013
cytokinetic processGO:003250620.013
purine ribonucleoside triphosphate catabolic processGO:00092071990.013
neural tube formationGO:00018411080.012
gastrulationGO:00073691160.012
viral entry into host cellGO:0046718150.012
chemotaxisGO:00069352470.012
dna methylationGO:0006306430.012
mesodermal cell migrationGO:000807840.012
negative regulation of b cell differentiationGO:004557840.012
ribonucleoside metabolic processGO:00091192450.012
double strand break repair via nonhomologous end joiningGO:0006303100.012
fertilizationGO:00095661270.012
dna endoreduplicationGO:004202340.012
germ cell proliferationGO:003609370.012
positive regulation of dna replicationGO:004574090.011
nucleic acid transportGO:0050657180.011
double strand break repairGO:0006302480.011
cell junction organizationGO:0034330770.011
response to uvGO:0009411440.011
digestive system developmentGO:00551232000.011
guanosine containing compound catabolic processGO:19010691440.011
cognitionGO:00508901490.011
angiogenesisGO:00015252010.011
negative regulation of cell activationGO:00508661110.011
positive regulation of cellular carbohydrate metabolic processGO:0010676290.011
camera type eye developmentGO:00430102660.011
ear developmentGO:00435832000.011
regulation of organelle assemblyGO:1902115190.011
rna splicingGO:0008380540.011
regulation of peptidase activityGO:0052547960.011
heterochromatin organizationGO:007082840.011
synaptonemal complex assemblyGO:0007130130.011
negative regulation of immune system processGO:00026832090.011
cell growthGO:00160491300.011
regulation of embryonic developmentGO:0045995710.011
meiotic dna double strand break formationGO:004213830.011
cell recognitionGO:0008037830.011
organonitrogen compound catabolic processGO:19015652640.011
regulation of leukocyte differentiationGO:19021051590.011
negative regulation of wnt signaling pathwayGO:0030178730.010
mapk cascadeGO:00001652810.010
g1 s transition of mitotic cell cycleGO:0000082570.010
proteasomal protein catabolic processGO:0010498980.010
positive regulation of homeostatic processGO:0032846640.010
cell migration involved in gastrulationGO:0042074130.010
regulation of intracellular protein transportGO:0033157820.010
protein ubiquitinationGO:00165671710.010
monosaccharide metabolic processGO:00059961060.010
regulation of myeloid leukocyte differentiationGO:0002761580.010
regulation of neuron apoptotic processGO:00435231220.010

Smc4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
physical disorderDOID:008001500.012
central nervous system diseaseDOID:33100.012
amyotrophic lateral sclerosisDOID:33200.012
nervous system diseaseDOID:86300.012
neurodegenerative diseaseDOID:128900.012
motor neuron diseaseDOID:23100.012
disease of anatomical entityDOID:700.012