IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Fez1

fasciculation and elongation protein zeta 1 (zygin I)

(Aliases: UNC-76,MGC19293,UNC76)

Entrez: 235180
Ensembl: ENSMUSG00000032118
UniProtKB: Q8K0X8

Process Predictions
Disease Predictions

Fez1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of organelle organization	GO:0033043	289	0.162
protein polymerization	GO:0051258	57	0.145
developmental growth involved in morphogenesis	GO:0060560	138	0.123	Worm
regulation of cytoskeleton organization	GO:0051493	122	0.121
spermatogenesis	GO:0007283	284	0.108
microtubule based process	GO:0007017	236	0.100	Fly
axonogenesis	GO:0007409	274	0.089	Worm
regulation of actin nucleation	GO:0051125	4	0.089
neural precursor cell proliferation	GO:0061351	121	0.088
chemotaxis	GO:0006935	247	0.084
regulation of neuron projection development	GO:0010975	169	0.084	Worm
axonal fasciculation	GO:0007413	15	0.081	Worm
male gamete generation	GO:0048232	285	0.074
rac protein signal transduction	GO:0016601	13	0.071
cell growth	GO:0016049	130	0.069	Worm
positive regulation of actin nucleation	GO:0051127	3	0.065
developmental cell growth	GO:0048588	84	0.063	Worm
genetic imprinting	GO:0071514	27	0.062
regulation of cell growth	GO:0001558	91	0.061	Worm
regulation of cell motility	GO:2000145	236	0.060
regulation of neuron differentiation	GO:0045664	281	0.059	Worm
nucleoside phosphate metabolic process	GO:0006753	338	0.054
neuron death	GO:0070997	154	0.054
protein catabolic process	GO:0030163	221	0.047
positive regulation of cell death	GO:0010942	224	0.047
sialylation	GO:0097503	14	0.046
regulation of neuron death	GO:1901214	134	0.046
asymmetric neuroblast division	GO:0055059	1	0.046
response to organic cyclic compound	GO:0014070	198	0.045
striated muscle tissue development	GO:0014706	293	0.045
positive regulation of apoptotic process	GO:0043065	217	0.045
neuron projection extension	GO:1990138	64	0.044	Worm
multicellular organismal signaling	GO:0035637	91	0.043
peripheral nervous system development	GO:0007422	53	0.042
membrane organization	GO:0061024	245	0.042
microtubule based movement	GO:0007018	84	0.042	Fly
nucleotide metabolic process	GO:0009117	332	0.041
asymmetric stem cell division	GO:0098722	3	0.041
response to caffeine	GO:0031000	6	0.041
neuron recognition	GO:0008038	25	0.040	Worm
spermatid development	GO:0007286	108	0.040
organophosphate catabolic process	GO:0046434	232	0.039
axon guidance	GO:0007411	141	0.039
actin cytoskeleton organization	GO:0030036	220	0.039
gliogenesis	GO:0042063	141	0.039
actin filament polymerization	GO:0030041	44	0.038
cell division	GO:0051301	120	0.038
cell type specific apoptotic process	GO:0097285	268	0.038
regulation of actin filament polymerization	GO:0030833	38	0.038
positive regulation of programmed cell death	GO:0043068	218	0.037
negative regulation of nervous system development	GO:0051961	156	0.037
regulation of cellular component size	GO:0032535	121	0.037	Worm
ribonucleotide metabolic process	GO:0009259	291	0.037
macromolecule catabolic process	GO:0009057	281	0.037
peripheral nervous system neuron axonogenesis	GO:0048936	3	0.036
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.036
negative regulation of cell development	GO:0010721	169	0.036
regulation of anatomical structure size	GO:0090066	178	0.036	Worm
neuron apoptotic process	GO:0051402	142	0.036
positive regulation of neuron differentiation	GO:0045666	141	0.036
microtubule cytoskeleton organization	GO:0000226	157	0.035
inorganic ion transmembrane transport	GO:0098660	234	0.035
regulation of cell cycle process	GO:0010564	160	0.035
apoptotic signaling pathway	GO:0097190	306	0.035
regulation of protein complex assembly	GO:0043254	83	0.035
positive regulation of cell projection organization	GO:0031346	95	0.035
sensory perception	GO:0007600	245	0.034
cellular response to dna damage stimulus	GO:0006974	207	0.034
small gtpase mediated signal transduction	GO:0007264	97	0.034
actin filament organization	GO:0007015	113	0.034
neurotrophin signaling pathway	GO:0038179	12	0.033
cytoplasmic transport	GO:0016482	234	0.032
organelle assembly	GO:0070925	177	0.032
regulation of intracellular transport	GO:0032386	159	0.032
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.031	Worm
cell recognition	GO:0008037	83	0.031	Worm
glycosyl compound metabolic process	GO:1901657	246	0.031
cellular protein complex assembly	GO:0043623	116	0.030
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.030
microtubule polymerization or depolymerization	GO:0031109	26	0.029
maintenance of presynaptic active zone structure	GO:0048790	1	0.029
spermatid differentiation	GO:0048515	115	0.028
germ cell development	GO:0007281	185	0.028
regulation of vesicle mediated transport	GO:0060627	139	0.028
regulation of actin filament length	GO:0030832	45	0.028
cellular component assembly involved in morphogenesis	GO:0010927	139	0.028
muscle cell differentiation	GO:0042692	261	0.028
regulation of cellular ketone metabolic process	GO:0010565	66	0.027
positive regulation of organelle organization	GO:0010638	128	0.027
actin polymerization or depolymerization	GO:0008154	54	0.027
regulation of neuron apoptotic process	GO:0043523	122	0.027
positive regulation of neuron projection development	GO:0010976	79	0.027
transmembrane transport	GO:0055085	412	0.027
regulation of neural precursor cell proliferation	GO:2000177	70	0.027
regulation of microtubule based process	GO:0032886	52	0.026
stem cell proliferation	GO:0072089	117	0.026
regulation of feeding behavior	GO:0060259	3	0.026
multicellular organismal homeostasis	GO:0048871	164	0.026
myelination in peripheral nervous system	GO:0022011	19	0.026
ribose phosphate metabolic process	GO:0019693	291	0.025
glial cell development	GO:0021782	54	0.025
nucleoside triphosphate metabolic process	GO:0009141	230	0.024
engulfment of apoptotic cell	GO:0043652	3	0.024
purine nucleoside catabolic process	GO:0006152	205	0.024
regulation of eosinophil migration	GO:2000416	2	0.024
regulation of cell migration	GO:0030334	219	0.023
regulation of cellular component biogenesis	GO:0044087	181	0.023
positive regulation of cell development	GO:0010720	237	0.023
negative regulation of intracellular signal transduction	GO:1902532	167	0.023
regulation of membrane potential	GO:0042391	192	0.023
cation transmembrane transport	GO:0098655	266	0.023
muscle cell development	GO:0055001	133	0.023
cation transport	GO:0006812	399	0.023
purine ribonucleoside metabolic process	GO:0046128	241	0.022
purine nucleoside metabolic process	GO:0042278	241	0.022
cellular ketone metabolic process	GO:0042180	84	0.022
negative regulation of protein metabolic process	GO:0051248	282	0.022
establishment of organelle localization	GO:0051656	122	0.022
regulation of microtubule polymerization or depolymerization	GO:0031110	20	0.022
divalent metal ion transport	GO:0070838	172	0.022
negative regulation of neuron death	GO:1901215	98	0.021
regulation of cell projection organization	GO:0031344	206	0.021	Worm
response to growth factor	GO:0070848	198	0.021
positive regulation of actin filament polymerization	GO:0030838	26	0.021
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.021
positive regulation of thymocyte migration	GO:2000412	2	0.021
cell junction assembly	GO:0034329	52	0.021
lateral inhibition	GO:0046331	1	0.021
negative regulation of cell proliferation	GO:0008285	296	0.021
rho protein signal transduction	GO:0007266	32	0.021
mitotic cell cycle	GO:0000278	195	0.021
fat cell differentiation	GO:0045444	160	0.021
intracellular protein transport	GO:0006886	204	0.020
muscle tissue development	GO:0060537	308	0.020
membrane lipid biosynthetic process	GO:0046467	32	0.020
dna dependent dna replication maintenance of fidelity	GO:0045005	3	0.020
rhythmic process	GO:0048511	174	0.020
organic cyclic compound catabolic process	GO:1901361	295	0.020
antibacterial peptide biosynthetic process	GO:0002780	2	0.020
snare complex disassembly	GO:0035494	2	0.020
transmission of nerve impulse	GO:0019226	76	0.020
axon target recognition	GO:0007412	4	0.020
regulation of nucleocytoplasmic transport	GO:0046822	73	0.020
chromatin modification	GO:0016568	187	0.020
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.020
regulation of metal ion transport	GO:0010959	106	0.020
positive regulation of nervous system development	GO:0051962	221	0.020
compound eye development	GO:0048749	1	0.020
myelination	GO:0042552	74	0.020
negative regulation of dna replication	GO:0008156	4	0.020
negative regulation of organelle organization	GO:0010639	90	0.020
wound healing	GO:0042060	157	0.020
ribonucleoside metabolic process	GO:0009119	245	0.019
bmp signaling pathway	GO:0030509	93	0.019
protein localization to organelle	GO:0033365	185	0.019
leukocyte migration	GO:0050900	124	0.019
purine ribonucleoside catabolic process	GO:0046130	205	0.019
response to nutrient levels	GO:0031667	109	0.019
purine ribonucleotide catabolic process	GO:0009154	208	0.019
negative regulation of phospholipase activity	GO:0010519	4	0.019
nucleoside phosphate catabolic process	GO:1901292	222	0.018
response to organonitrogen compound	GO:0010243	246	0.018
response to extracellular stimulus	GO:0009991	127	0.018
ras protein signal transduction	GO:0007265	77	0.018
purine containing compound metabolic process	GO:0072521	311	0.018
regulation of hydrolase activity	GO:0051336	246	0.018
purine nucleotide catabolic process	GO:0006195	211	0.018
cellular nitrogen compound catabolic process	GO:0044270	280	0.018
cellular response to oxidative stress	GO:0034599	76	0.018
regulation of rac protein signal transduction	GO:0035020	19	0.018
circadian regulation of gene expression	GO:0032922	48	0.018
negative regulation of cytoskeleton organization	GO:0051494	36	0.017
cell adhesion	GO:0007155	329	0.017
regulation of cell cycle	GO:0051726	281	0.017
purine nucleotide metabolic process	GO:0006163	302	0.017
negative regulation of neuron differentiation	GO:0045665	101	0.017
regulation of nucleotide metabolic process	GO:0006140	169	0.017
organelle localization	GO:0051640	179	0.017
organonitrogen compound biosynthetic process	GO:1901566	192	0.017
action potential	GO:0001508	78	0.017
negative regulation of cellular component organization	GO:0051129	194	0.017
regulation of actin polymerization or depolymerization	GO:0008064	45	0.017
learning or memory	GO:0007611	148	0.017
posttranscriptional regulation of gene expression	GO:0010608	155	0.017
negative regulation of cell cycle	GO:0045786	123	0.017
regulation of reproductive process	GO:2000241	66	0.017
microtubule polymerization	GO:0046785	12	0.017
positive regulation of eosinophil migration	GO:2000418	2	0.017
positive regulation of schwann cell proliferation	GO:0010625	1	0.016
organelle fission	GO:0048285	170	0.016
wnt signaling pathway	GO:0016055	188	0.016
nuclear division	GO:0000280	158	0.016
substantia nigra development	GO:0021762	2	0.016
cell fate commitment	GO:0045165	210	0.016
relaxation of muscle	GO:0090075	18	0.016
cardiac muscle tissue development	GO:0048738	130	0.016
aromatic compound catabolic process	GO:0019439	286	0.016
male genitalia morphogenesis	GO:0048808	4	0.016
positive regulation of protein export from nucleus	GO:0046827	4	0.016
neuroblast proliferation	GO:0007405	49	0.016
regulation of protein localization	GO:0032880	231	0.015
regulation of protein serine threonine kinase activity	GO:0071900	157	0.015
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.015
sensory organ morphogenesis	GO:0090596	242	0.015
regulation of multi organism process	GO:0043900	111	0.015
heterocycle catabolic process	GO:0046700	280	0.015
nucleoside triphosphate catabolic process	GO:0009143	205	0.015
tube formation	GO:0035148	140	0.015
regulation of actin filament based process	GO:0032970	99	0.015
neurotrophin trk receptor signaling pathway	GO:0048011	8	0.015
positive regulation of protein complex assembly	GO:0031334	45	0.015
methylation	GO:0032259	134	0.015
replication fork protection	GO:0048478	1	0.015
regulation of lymphocyte activation	GO:0051249	240	0.015
negative regulation of stem cell proliferation	GO:2000647	12	0.015
positive regulation of necrotic cell death	GO:0010940	1	0.015
positive regulation of synaptic plasticity	GO:0031915	4	0.015
regulation of protein kinase activity	GO:0045859	232	0.015
inter male aggressive behavior	GO:0002121	3	0.015
negative regulation of phosphorylation	GO:0042326	166	0.014
myeloid cell differentiation	GO:0030099	233	0.014
gtp metabolic process	GO:0046039	144	0.014
striated muscle cell development	GO:0055002	125	0.014
dendrite development	GO:0016358	115	0.014
schwann cell development	GO:0014044	22	0.014
myeloid leukocyte migration	GO:0097529	57	0.014
negative regulation of molecular function	GO:0044092	258	0.014
thymocyte migration	GO:0072679	2	0.014
regulation of fat cell differentiation	GO:0045598	81	0.014
epidermis development	GO:0008544	187	0.014
meiotic nuclear division	GO:0007126	115	0.014
regulation of extent of cell growth	GO:0061387	52	0.014	Worm
vesicle localization	GO:0051648	86	0.013
regulation of ion transport	GO:0043269	215	0.013
nucleoside catabolic process	GO:0009164	206	0.013
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.013
positive regulation of protein modification process	GO:0031401	299	0.013
cell chemotaxis	GO:0060326	81	0.013
maintenance of location	GO:0051235	89	0.013
molting cycle	GO:0042303	90	0.013
mapk cascade	GO:0000165	281	0.013
regulation of transferase activity	GO:0051338	263	0.013
protein processing	GO:0016485	163	0.013
positive regulation of intracellular protein transport	GO:0090316	42	0.013
regulation of cytoplasmic transport	GO:1903649	112	0.013
leukocyte chemotaxis	GO:0030595	69	0.013
positive regulation of glial cell proliferation	GO:0060252	4	0.013
localization within membrane	GO:0051668	4	0.013
hematopoietic progenitor cell differentiation	GO:0002244	143	0.013
gland development	GO:0048732	330	0.013
positive regulation of cytoskeleton organization	GO:0051495	49	0.013
protein complex disassembly	GO:0043241	40	0.013
positive regulation of mapk cascade	GO:0043410	170	0.013
cognition	GO:0050890	149	0.013
carbohydrate derivative catabolic process	GO:1901136	231	0.013
positive regulation of cellular amine metabolic process	GO:0033240	5	0.013
stem cell differentiation	GO:0048863	268	0.013
positive regulation of protein phosphorylation	GO:0001934	242	0.012
regulation of cell size	GO:0008361	72	0.012	Worm
positive regulation of membrane protein ectodomain proteolysis	GO:0051044	3	0.012
sodium ion transport	GO:0006814	73	0.012
negative regulation of dna dependent dna replication	GO:2000104	1	0.012
midgut development	GO:0007494	4	0.012
axon ensheathment	GO:0008366	76	0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.012
negative regulation of neuroblast proliferation	GO:0007406	7	0.012
locomotory behavior	GO:0007626	195	0.012
schwann cell differentiation	GO:0014037	26	0.012
regulation of kinase activity	GO:0043549	249	0.012
neuron migration	GO:0001764	122	0.012
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.012
positive regulation of growth	GO:0045927	104	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.012
myeloid leukocyte differentiation	GO:0002573	119	0.012
cellular response to extracellular stimulus	GO:0031668	81	0.012
glycosyl compound catabolic process	GO:1901658	206	0.012
regulation of angiogenesis	GO:0045765	81	0.012
cell junction organization	GO:0034330	77	0.012
developmental maturation	GO:0021700	193	0.012
positive regulation of fat cell differentiation	GO:0045600	32	0.012
regulation of rac gtpase activity	GO:0032314	13	0.012
glial cell differentiation	GO:0010001	131	0.011
regulation of proteolysis	GO:0030162	164	0.011
regulation of actin cytoskeleton organization	GO:0032956	84	0.011
muscle fiber development	GO:0048747	76	0.011
regulation of neuroblast proliferation	GO:1902692	27	0.011
cellular metal ion homeostasis	GO:0006875	151	0.011
regulation of cell projection assembly	GO:0060491	38	0.011
respiratory system process	GO:0003016	25	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.011
regulation of wnt signaling pathway	GO:0030111	123	0.011
response to starvation	GO:0042594	65	0.011
nucleocytoplasmic transport	GO:0006913	139	0.011
regulation of calcium ion transport	GO:0051924	69	0.011
adult behavior	GO:0030534	135	0.011
cellular amino acid metabolic process	GO:0006520	103	0.011
purine ribonucleotide metabolic process	GO:0009150	290	0.011
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.011
homeostasis of number of cells	GO:0048872	210	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.011
negative regulation of neuron apoptotic process	GO:0043524	92	0.011
positive regulation of protein localization to nucleus	GO:1900182	30	0.011
response to radiation	GO:0009314	165	0.011
cell cycle checkpoint	GO:0000075	47	0.011
skeletal muscle organ development	GO:0060538	163	0.011
eosinophil migration	GO:0072677	3	0.011
phosphatidic acid biosynthetic process	GO:0006654	2	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.011
neuronal action potential	GO:0019228	54	0.011
oxidation reduction process	GO:0055114	342	0.011
single organism cell adhesion	GO:0098602	156	0.011
development of primary sexual characteristics	GO:0045137	143	0.011
response to acid chemical	GO:0001101	111	0.011
single organismal cell cell adhesion	GO:0016337	131	0.011
positive regulation of cardiac muscle contraction	GO:0060452	2	0.011
establishment of glial blood brain barrier	GO:0060857	2	0.011
purine containing compound catabolic process	GO:0072523	213	0.011
cerebellum development	GO:0021549	77	0.011
establishment of vesicle localization	GO:0051650	81	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.011
cellular response to nutrient levels	GO:0031669	64	0.011
striated muscle cell proliferation	GO:0014855	39	0.011
eye photoreceptor cell development	GO:0042462	31	0.011
negative regulation of neural precursor cell proliferation	GO:2000178	18	0.011
negative regulation of rac protein signal transduction	GO:0035021	4	0.011
regulation of exocytosis	GO:0017157	61	0.011
organonitrogen compound catabolic process	GO:1901565	264	0.011
exocytosis	GO:0006887	121	0.011
negative regulation of protein processing	GO:0010955	79	0.011
erythrocyte differentiation	GO:0030218	88	0.010
negative regulation of microtubule polymerization	GO:0031115	2	0.010
cell cell junction assembly	GO:0007043	27	0.010
mitotic cell cycle process	GO:1903047	159	0.010
regulation of cellular amino acid metabolic process	GO:0006521	5	0.010
smoothened signaling pathway	GO:0007224	105	0.010
cellular amine metabolic process	GO:0044106	44	0.010
innate immune response	GO:0045087	157	0.010
cell proliferation in external granule layer	GO:0021924	10	0.010
response to oxidative stress	GO:0006979	123	0.010
chromatin organization	GO:0006325	206	0.010
male anatomical structure morphogenesis	GO:0090598	4	0.010
negative regulation of dendritic spine development	GO:0061000	3	0.010
cellular response to lipid	GO:0071396	145	0.010
intermediate filament bundle assembly	GO:0045110	3	0.010

Fez1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.022
nervous system disease	DOID:863	0.022
central nervous system disease	DOID:331	0.021

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