IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Pmpca

peptidase (mitochondrial processing) alpha

(Aliases: 1200002L24Rik,P-55,4933435E07Rik,Alpha-MPP)

Entrez: 66865
Ensembl: ENSMUSG00000026926
UniProtKB: Q9DC61

Process Predictions
Disease Predictions

Pmpca biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mitochondrion organization	GO:0007005	134	0.133	Yeast
pole plasm assembly	GO:0007315	2	0.057
transmembrane transport	GO:0055085	412	0.052
spermatogenesis	GO:0007283	284	0.052
oocyte axis specification	GO:0007309	2	0.042
male gamete generation	GO:0048232	285	0.041
rna processing	GO:0006396	105	0.041
ion transmembrane transport	GO:0034220	361	0.039
cellular amino acid metabolic process	GO:0006520	103	0.038
cellular response to dna damage stimulus	GO:0006974	207	0.037
translation	GO:0006412	93	0.034
cytoplasmic transport	GO:0016482	234	0.033	Yeast
posttranscriptional regulation of gene expression	GO:0010608	155	0.033
germ cell development	GO:0007281	185	0.032
oocyte anterior posterior axis specification	GO:0007314	2	0.032
cation transport	GO:0006812	399	0.031
membrane organization	GO:0061024	245	0.028
macromolecule catabolic process	GO:0009057	281	0.028
protein maturation	GO:0051604	176	0.025	Yeast
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.024
intrinsic apoptotic signaling pathway	GO:0097193	132	0.023
meiotic nuclear division	GO:0007126	115	0.023
cellular chemical homeostasis	GO:0055082	215	0.023
cellular protein complex assembly	GO:0043623	116	0.023
regulation of apoptotic signaling pathway	GO:2001233	197	0.022
apoptotic signaling pathway	GO:0097190	306	0.022
positive regulation of programmed cell death	GO:0043068	218	0.021
protein catabolic process	GO:0030163	221	0.021
cellular response to hormone stimulus	GO:0032870	150	0.021
regulation of cell cycle	GO:0051726	281	0.021
organelle fission	GO:0048285	170	0.021
endocytosis	GO:0006897	168	0.020
multicellular organism growth	GO:0035264	161	0.020
positive regulation of cell death	GO:0010942	224	0.020
intracellular mrna localization	GO:0008298	4	0.019
microtubule based process	GO:0007017	236	0.019
mitochondrial calcium ion homeostasis	GO:0051560	7	0.019
developmental maturation	GO:0021700	193	0.019
cellular homeostasis	GO:0019725	240	0.019
nucleoside phosphate metabolic process	GO:0006753	338	0.019
cellular ion homeostasis	GO:0006873	165	0.019
cation transmembrane transport	GO:0098655	266	0.018
spermatid development	GO:0007286	108	0.018
positive regulation of apoptotic process	GO:0043065	217	0.018
protein localization to organelle	GO:0033365	185	0.018	Yeast
organelle localization	GO:0051640	179	0.018
cation homeostasis	GO:0055080	212	0.018
response to oxidative stress	GO:0006979	123	0.018
oocyte construction	GO:0007308	2	0.018
positive regulation of protein phosphorylation	GO:0001934	242	0.018
regulation of cellular response to stress	GO:0080135	159	0.018
response to organic cyclic compound	GO:0014070	198	0.017
protein targeting	GO:0006605	143	0.017	Yeast
regulation of organelle organization	GO:0033043	289	0.017
response to organonitrogen compound	GO:0010243	246	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.017
cellular amine metabolic process	GO:0044106	44	0.017
regulation of proteolysis	GO:0030162	164	0.017
peptidyl amino acid modification	GO:0018193	336	0.016
regulation of cellular amino acid metabolic process	GO:0006521	5	0.016
homeostasis of number of cells	GO:0048872	210	0.016
muscle cell differentiation	GO:0042692	261	0.016
protein processing	GO:0016485	163	0.016	Yeast
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.016
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.016
organic anion transport	GO:0015711	137	0.016
protein modification by small protein conjugation or removal	GO:0070647	207	0.015
amine metabolic process	GO:0009308	45	0.015
epithelial tube morphogenesis	GO:0060562	303	0.015
locomotory behavior	GO:0007626	195	0.015
regulation of cell migration	GO:0030334	219	0.015
circadian rhythm	GO:0007623	114	0.015
muscle tissue development	GO:0060537	308	0.015
intracellular protein transport	GO:0006886	204	0.015	Yeast
regulation of transferase activity	GO:0051338	263	0.015
regulation of cellular ketone metabolic process	GO:0010565	66	0.015
cellular ketone metabolic process	GO:0042180	84	0.015
nucleobase containing small molecule metabolic process	GO:0055086	352	0.015
cellular macromolecule catabolic process	GO:0044265	206	0.015
protein modification by small protein conjugation	GO:0032446	187	0.014
spermatid differentiation	GO:0048515	115	0.014
cellular response to organonitrogen compound	GO:0071417	145	0.014
nitrogen compound transport	GO:0071705	271	0.014
aromatic compound catabolic process	GO:0019439	286	0.014
striated muscle tissue development	GO:0014706	293	0.014
carbohydrate metabolic process	GO:0005975	230	0.014
lateral inhibition	GO:0046331	1	0.014
regulation of kinase activity	GO:0043549	249	0.014
nucleocytoplasmic transport	GO:0006913	139	0.014
cellular metal ion homeostasis	GO:0006875	151	0.014
b cell activation	GO:0042113	161	0.014
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.014
cell maturation	GO:0048469	127	0.014
positive regulation of cellular amine metabolic process	GO:0033240	5	0.013
negative regulation of intracellular signal transduction	GO:1902532	167	0.013
rna splicing	GO:0008380	54	0.013
inorganic cation transmembrane transport	GO:0098662	207	0.013
glutamate biosynthetic process	GO:0006537	2	0.013
mitotic cell cycle	GO:0000278	195	0.013
rna interference	GO:0016246	2	0.013
protein import	GO:0017038	101	0.013
regulation of cell activation	GO:0050865	289	0.013
rna splicing via transesterification reactions	GO:0000375	43	0.012
inorganic ion transmembrane transport	GO:0098660	234	0.012
cellular response to cytokine stimulus	GO:0071345	189	0.012
nucleoside phosphate catabolic process	GO:1901292	222	0.012
oxidation reduction process	GO:0055114	342	0.012
purine containing compound metabolic process	GO:0072521	311	0.012
mitotic cell cycle process	GO:1903047	159	0.012
protein localization to membrane	GO:0072657	108	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.012
organonitrogen compound biosynthetic process	GO:1901566	192	0.012
regulation of ion transport	GO:0043269	215	0.012
cellularization	GO:0007349	1	0.012
anion transport	GO:0006820	177	0.012
multicellular organismal signaling	GO:0035637	91	0.012
male sex differentiation	GO:0046661	109	0.012
carboxylic acid biosynthetic process	GO:0046394	86	0.011
multi multicellular organism process	GO:0044706	109	0.011
cell type specific apoptotic process	GO:0097285	268	0.011
oocyte differentiation	GO:0009994	35	0.011
organic cyclic compound catabolic process	GO:1901361	295	0.011
neuron death	GO:0070997	154	0.011
modification dependent protein catabolic process	GO:0019941	133	0.011
regulation of membrane potential	GO:0042391	192	0.011
regulation of intracellular transport	GO:0032386	159	0.011
regulation of lymphocyte activation	GO:0051249	240	0.011
cellular nitrogen compound catabolic process	GO:0044270	280	0.011
regulation of cellular amine metabolic process	GO:0033238	20	0.011
stem cell differentiation	GO:0048863	268	0.011
regulation of cell motility	GO:2000145	236	0.011
establishment of protein localization to organelle	GO:0072594	118	0.011	Yeast
fertilization	GO:0009566	127	0.011
alcohol metabolic process	GO:0006066	116	0.011
compound eye development	GO:0048749	1	0.011
heterocycle catabolic process	GO:0046700	280	0.011
carbohydrate derivative biosynthetic process	GO:1901137	183	0.011
cell adhesion	GO:0007155	329	0.011
dephosphorylation	GO:0016311	129	0.011
regulation of wnt signaling pathway	GO:0030111	123	0.010
transmission of nerve impulse	GO:0019226	76	0.010
nuclear division	GO:0000280	158	0.010
regulation of cellular component biogenesis	GO:0044087	181	0.010
positive regulation of hydrolase activity	GO:0051345	148	0.010
proteasomal protein catabolic process	GO:0010498	98	0.010
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.010
mitotic nuclear division	GO:0007067	48	0.010
response to acid chemical	GO:0001101	111	0.010
glutamine family amino acid biosynthetic process	GO:0009084	2	0.010
lymphocyte mediated immunity	GO:0002449	139	0.010

Pmpca disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.030
nervous system disease	DOID:863	0.030
neurodegenerative disease	DOID:1289	0.022
central nervous system disease	DOID:331	0.022
inherited metabolic disorder	DOID:655	0.012
disease of metabolism	DOID:0014667	0.012
sensory system disease	DOID:0050155	0.010
eye and adnexa disease	DOID:1492	0.010
eye disease	DOID:5614	0.010

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