IMP: Integrative Multi-species Prediction

Mus musculus

149 known processes

Slc40a1

solute carrier family 40 (iron-regulated transporter), member 1

(Aliases: IREG1,Slc11a3,MTP,Dusg,Fpn1,MTP1,Ol5,Pcm,Slc39a1)

Ensembl: ENSMUSG00000025993
Entrez: 53945
UniProtKB: Q9JHI9

Process Predictions
Disease Predictions

Slc40a1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
iron ion homeostasis	GO:0055072	36	0.997
iron ion import	GO:0097286	5	0.995
myeloid cell homeostasis	GO:0002262	114	0.986	Zebrafish
erythrocyte differentiation	GO:0030218	88	0.973	Zebrafish
cation homeostasis	GO:0055080	212	0.942
multicellular organismal iron ion homeostasis	GO:0060586	8	0.940
cation transport	GO:0006812	399	0.934
response to iron ion	GO:0010039	4	0.928
transition metal ion homeostasis	GO:0055076	54	0.885
oxidation reduction process	GO:0055114	342	0.856
glutathione metabolic process	GO:0006749	16	0.788
transition metal ion transport	GO:0000041	38	0.732
cofactor metabolic process	GO:0051186	80	0.723
iron ion transport	GO:0006826	17	0.707
homeostasis of number of cells	GO:0048872	210	0.641
myeloid cell differentiation	GO:0030099	233	0.627	Zebrafish
iron ion import into cell	GO:0097459	4	0.614
metal ion homeostasis	GO:0055065	189	0.549
blood coagulation	GO:0007596	76	0.535
response to oxidative stress	GO:0006979	123	0.519
porphyrin containing compound metabolic process	GO:0006778	22	0.518
cellular metal ion homeostasis	GO:0006875	151	0.512
positive regulation of t cell mediated cytotoxicity	GO:0001916	15	0.511
cytokine production	GO:0001816	319	0.485
tetrapyrrole metabolic process	GO:0033013	22	0.473
wound healing	GO:0042060	157	0.459
copper ion transport	GO:0006825	10	0.447
coagulation	GO:0050817	78	0.444
positive regulation of cell death	GO:0010942	224	0.429
t cell activation	GO:0042110	289	0.416
cellular iron ion homeostasis	GO:0006879	16	0.394
t cell activation involved in immune response	GO:0002286	43	0.382
hemostasis	GO:0007599	78	0.354
trivalent inorganic cation transport	GO:0072512	5	0.353
cellular transition metal ion homeostasis	GO:0046916	32	0.333
leukocyte activation involved in immune response	GO:0002366	126	0.311
positive regulation of natural killer cell mediated immunity	GO:0002717	16	0.289
regulation of t cell mediated cytotoxicity	GO:0001914	18	0.288
antigen processing and presentation	GO:0019882	47	0.286
t cell mediated immunity	GO:0002456	50	0.279
cellular response to arsenic containing substance	GO:0071243	4	0.271
antigen processing and presentation of peptide antigen	GO:0048002	29	0.266
inorganic ion transmembrane transport	GO:0098660	234	0.263
cell killing	GO:0001906	67	0.238
regulation of apoptotic signaling pathway	GO:2001233	197	0.236
immune effector process	GO:0002252	321	0.235
copper ion transmembrane transport	GO:0035434	5	0.234
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.228
response to molecule of bacterial origin	GO:0002237	143	0.226
positive regulation of defense response	GO:0031349	124	0.221
cellular amino acid metabolic process	GO:0006520	103	0.204
cell activation involved in immune response	GO:0002263	126	0.204
cytokine production involved in immune response	GO:0002367	34	0.202
heme metabolic process	GO:0042168	16	0.198
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.195
lymphocyte proliferation	GO:0046651	164	0.195
reactive oxygen species biosynthetic process	GO:1903409	8	0.190
posttranscriptional regulation of gene expression	GO:0010608	155	0.176
organic anion transport	GO:0015711	137	0.174
hormone metabolic process	GO:0042445	86	0.174
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.171
arginine transport	GO:0015809	4	0.171
t cell mediated cytotoxicity	GO:0001913	26	0.166
leukocyte differentiation	GO:0002521	342	0.165
lymphocyte mediated immunity	GO:0002449	139	0.163
cofactor biosynthetic process	GO:0051188	41	0.163
response to metal ion	GO:0010038	47	0.161
myeloid leukocyte differentiation	GO:0002573	119	0.157
reactive oxygen species metabolic process	GO:0072593	84	0.154
regulation of cytokine production	GO:0001817	266	0.152
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.149
heme biosynthetic process	GO:0006783	12	0.148
response to starvation	GO:0042594	65	0.146
defense response to bacterium	GO:0042742	119	0.142
positive regulation of apoptotic process	GO:0043065	217	0.140
inorganic cation import into cell	GO:0098659	4	0.139
production of molecular mediator of immune response	GO:0002440	103	0.138
regulation of natural killer cell mediated immunity	GO:0002715	19	0.133
pigment metabolic process	GO:0042440	32	0.133
response to lipopolysaccharide	GO:0032496	128	0.133
folic acid containing compound metabolic process	GO:0006760	3	0.131
positive regulation of cytokine production	GO:0001819	174	0.130
anion transport	GO:0006820	177	0.122
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.122
positive regulation of phagocytosis	GO:0050766	26	0.120
ion transmembrane transport	GO:0034220	361	0.119
regulation of cellular catabolic process	GO:0031329	242	0.118
transmembrane transport	GO:0055085	412	0.117
organ regeneration	GO:0031100	2	0.117
circulatory system process	GO:0003013	197	0.114
leukocyte mediated immunity	GO:0002443	174	0.114
multicellular organismal homeostasis	GO:0048871	164	0.114
antigen processing and presentation of exogenous peptide antigen via mhc class ib	GO:0002477	3	0.111
cellular chemical homeostasis	GO:0055082	215	0.111
porphyrin containing compound biosynthetic process	GO:0006779	16	0.110
regulation of ion transport	GO:0043269	215	0.109
interferon gamma production	GO:0032609	67	0.108
tetrapyrrole biosynthetic process	GO:0033014	16	0.104
regulation of body fluid levels	GO:0050878	162	0.103
adaptive immune response	GO:0002250	155	0.100
regulation of cellular ketone metabolic process	GO:0010565	66	0.100
cofactor catabolic process	GO:0051187	6	0.099
sulfur compound metabolic process	GO:0006790	100	0.099
regulation of hormone levels	GO:0010817	211	0.098
reactive nitrogen species metabolic process	GO:2001057	0	0.098
gland development	GO:0048732	330	0.096
cellular homeostasis	GO:0019725	240	0.095
regulation of leukocyte mediated immunity	GO:0002703	104	0.093
organic acid transport	GO:0015849	101	0.091
leukocyte proliferation	GO:0070661	172	0.091
regulation of defense response	GO:0031347	233	0.091
response to hypoxia	GO:0001666	58	0.087
cellular ion homeostasis	GO:0006873	165	0.087
regulation of translation	GO:0006417	71	0.087
lymphocyte activation involved in immune response	GO:0002285	93	0.087
import into cell	GO:0098657	8	0.086
sensory perception	GO:0007600	245	0.084
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.083
inorganic cation transmembrane transport	GO:0098662	207	0.083
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.081
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.079
lymphocyte homeostasis	GO:0002260	64	0.077
blood circulation	GO:0008015	195	0.075
nitrogen compound transport	GO:0071705	271	0.072
scf dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031146	10	0.071
divalent metal ion transport	GO:0070838	172	0.070
antigen processing and presentation of endogenous peptide antigen via mhc class ib	GO:0002476	4	0.070
response to inorganic substance	GO:0010035	96	0.069
interleukin 2 production	GO:0032623	33	0.068
translation	GO:0006412	93	0.068
regulation of transcription from rna polymerase ii promoter in response to iron	GO:0034395	3	0.067
regulation of translational initiation in response to stress	GO:0043558	5	0.067
positive regulation of cell killing	GO:0031343	33	0.066
cellular response to oxidative stress	GO:0034599	76	0.065
inorganic anion transport	GO:0015698	43	0.065
innate immune response	GO:0045087	157	0.064
positive regulation of protein modification process	GO:0031401	299	0.064
positive regulation of programmed cell death	GO:0043068	218	0.063
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.063
positive regulation of innate immune response	GO:0045089	80	0.062
positive regulation of adaptive immune response	GO:0002821	61	0.062
cell maturation	GO:0048469	127	0.062	Zebrafish
cellular response to extracellular stimulus	GO:0031668	81	0.062
natural killer cell mediated immunity	GO:0002228	29	0.062
positive regulation of immune effector process	GO:0002699	107	0.061
amino acid transport	GO:0006865	61	0.061
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.060
regulation of lymphocyte mediated immunity	GO:0002706	84	0.059
protein localization to organelle	GO:0033365	185	0.059
response to extracellular stimulus	GO:0009991	127	0.058
l amino acid transport	GO:0015807	32	0.058
antigen processing and presentation of peptide antigen via mhc class i	GO:0002474	9	0.057
cellular amine metabolic process	GO:0044106	44	0.057
t cell proliferation	GO:0042098	120	0.057
cellular response to cadmium ion	GO:0071276	3	0.057
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.056
modification dependent protein catabolic process	GO:0019941	133	0.056
intrinsic apoptotic signaling pathway	GO:0097193	132	0.056
coenzyme metabolic process	GO:0006732	52	0.055
hydrogen ion transmembrane transport	GO:1902600	25	0.055
learning or memory	GO:0007611	148	0.055
apoptotic signaling pathway	GO:0097190	306	0.054
organonitrogen compound biosynthetic process	GO:1901566	192	0.054
signal transduction by p53 class mediator	GO:0072331	51	0.054
cytoplasmic transport	GO:0016482	234	0.054
negative regulation of cytokine production	GO:0001818	84	0.052
regulation of adaptive immune response	GO:0002819	90	0.052
organonitrogen compound catabolic process	GO:1901565	264	0.052
regulation of interferon gamma production	GO:0032649	57	0.050
acute inflammatory response	GO:0002526	41	0.049
cellular response to nutrient levels	GO:0031669	64	0.049
antigen processing and presentation of exogenous antigen	GO:0019884	26	0.049
inflammatory response	GO:0006954	244	0.049
digestive system development	GO:0055123	200	0.048
pteridine containing compound metabolic process	GO:0042558	5	0.047
regulation of cell activation	GO:0050865	289	0.047
response to oxygen levels	GO:0070482	62	0.047
alpha beta t cell activation	GO:0046631	91	0.047
regulation of cell killing	GO:0031341	40	0.047
hormone biosynthetic process	GO:0042446	16	0.047
protein modification by small protein conjugation or removal	GO:0070647	207	0.046
cellular protein catabolic process	GO:0044257	155	0.046
regulation of cellular response to stress	GO:0080135	159	0.045
cation transmembrane transport	GO:0098655	266	0.045
cellular response to lipopolysaccharide	GO:0071222	77	0.045
regulation of innate immune response	GO:0045088	91	0.045
cellular amide metabolic process	GO:0043603	58	0.044
positive regulation of cellular catabolic process	GO:0031331	148	0.043
liver development	GO:0001889	66	0.043
macromolecule catabolic process	GO:0009057	281	0.042
protein ubiquitination	GO:0016567	171	0.042
positive regulation of t cell mediated immunity	GO:0002711	24	0.042
positive regulation of homeostatic process	GO:0032846	64	0.041
positive regulation of peptidase activity	GO:0010952	49	0.041
regulation of binding	GO:0051098	111	0.041
positive regulation of endopeptidase activity	GO:0010950	43	0.041
positive regulation of interferon gamma production	GO:0032729	39	0.040
carboxylic acid transport	GO:0046942	100	0.040
protein import	GO:0017038	101	0.040
protein localization to nucleus	GO:0034504	121	0.040
regulation of vesicle mediated transport	GO:0060627	139	0.040
rho protein signal transduction	GO:0007266	32	0.039
monosaccharide metabolic process	GO:0005996	106	0.039
hepaticobiliary system development	GO:0061008	67	0.039
urogenital system development	GO:0001655	261	0.039
positive regulation of cellular protein catabolic process	GO:1903364	34	0.038
regulation of t cell mediated immunity	GO:0002709	34	0.038
cellular response to external stimulus	GO:0071496	88	0.038
negative regulation of cell proliferation	GO:0008285	296	0.038
acute phase response	GO:0006953	10	0.038
regulation of peptidase activity	GO:0052547	96	0.038
regulation of secretion	GO:0051046	274	0.037
protein catabolic process	GO:0030163	221	0.037
ear development	GO:0043583	200	0.037
response to organic cyclic compound	GO:0014070	198	0.037
cellular response to starvation	GO:0009267	57	0.036
establishment of protein localization to organelle	GO:0072594	118	0.036
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.036
respiratory burst	GO:0045730	8	0.035
zymogen activation	GO:0031638	41	0.035
defense response to gram negative bacterium	GO:0050829	28	0.035
translational initiation	GO:0006413	24	0.034
divalent inorganic cation transport	GO:0072511	178	0.034
purine nucleotide catabolic process	GO:0006195	211	0.034
heterocycle catabolic process	GO:0046700	280	0.034
regulation of cellular amino acid metabolic process	GO:0006521	5	0.033
cellular lipid metabolic process	GO:0044255	323	0.033
i kappab kinase nf kappab signaling	GO:0007249	85	0.033
hydrogen transport	GO:0006818	35	0.033
stem cell differentiation	GO:0048863	268	0.033
activation of immune response	GO:0002253	138	0.032
natural killer cell mediated cytotoxicity	GO:0042267	29	0.032
cellular modified amino acid metabolic process	GO:0006575	63	0.032
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.032
regulation of t cell proliferation	GO:0042129	92	0.032
proteasomal protein catabolic process	GO:0010498	98	0.032
cellular response to lipid	GO:0071396	145	0.032
energy derivation by oxidation of organic compounds	GO:0015980	77	0.032
cellular ketone metabolic process	GO:0042180	84	0.032
multicellular organism growth	GO:0035264	161	0.031
nitric oxide metabolic process	GO:0046209	25	0.031
regulation of ph	GO:0006885	26	0.031
proton transport	GO:0015992	35	0.031
digestive tract development	GO:0048565	190	0.031
regulation of hydrolase activity	GO:0051336	246	0.030
sa node cell to atrial cardiac muscle cell signalling	GO:0086018	4	0.030
protein processing	GO:0016485	163	0.030
amine metabolic process	GO:0009308	45	0.030
chemotaxis	GO:0006935	247	0.030
positive regulation of hydrolase activity	GO:0051345	148	0.030
regulation of response to dna damage stimulus	GO:2001020	34	0.030
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.030
regulation of cellular ph	GO:0030641	12	0.029
ribose phosphate metabolic process	GO:0019693	291	0.029
osteoclast differentiation	GO:0030316	62	0.028
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.028
monovalent inorganic cation homeostasis	GO:0055067	33	0.028
regulation of removal of superoxide radicals	GO:2000121	4	0.028
inflammatory response to wounding	GO:0090594	4	0.028
response to organonitrogen compound	GO:0010243	246	0.028
nucleocytoplasmic transport	GO:0006913	139	0.028
nucleoside triphosphate metabolic process	GO:0009141	230	0.028
purine containing compound metabolic process	GO:0072521	311	0.027
response to epidermal growth factor	GO:0070849	4	0.027
metencephalon development	GO:0022037	89	0.027
angiogenesis	GO:0001525	201	0.027
regulation of neuron death	GO:1901214	134	0.027
protein oligomerization	GO:0051259	67	0.027
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.027
regulation of natural killer cell mediated cytotoxicity	GO:0042269	19	0.027
regulation of kinase activity	GO:0043549	249	0.026
activation of cysteine type endopeptidase activity	GO:0097202	27	0.026
single organism nuclear import	GO:1902593	95	0.026
cellular response to dna damage stimulus	GO:0006974	207	0.026
nucleotide metabolic process	GO:0009117	332	0.026
endocytosis	GO:0006897	168	0.026
aromatic compound catabolic process	GO:0019439	286	0.026
regulation of transferase activity	GO:0051338	263	0.026
detection of stimulus	GO:0051606	84	0.026
nitric oxide biosynthetic process	GO:0006809	25	0.026
intracellular protein transport	GO:0006886	204	0.026
neuron death	GO:0070997	154	0.025
regulation of lymphocyte activation	GO:0051249	240	0.025
regulation of protein binding	GO:0043393	60	0.025
exocytosis	GO:0006887	121	0.025
tissue homeostasis	GO:0001894	115	0.025
organic cyclic compound catabolic process	GO:1901361	295	0.025
nuclear import	GO:0051170	95	0.025
myeloid leukocyte activation	GO:0002274	83	0.025
regulation of intracellular ph	GO:0051453	11	0.025
interleukin 1 production	GO:0032612	31	0.025
extrinsic apoptotic signaling pathway	GO:0097191	126	0.024
purine nucleoside metabolic process	GO:0042278	241	0.024
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.024
inorganic ion import into cell	GO:0099587	4	0.024
regulation of cellular amine metabolic process	GO:0033238	20	0.024
positive regulation of proteolysis	GO:0045862	85	0.024
hemoglobin metabolic process	GO:0020027	13	0.024	Zebrafish
glycosyl compound metabolic process	GO:1901657	246	0.024
regulation of anatomical structure size	GO:0090066	178	0.024
muscle system process	GO:0003012	141	0.024
regulation of homeostatic process	GO:0032844	182	0.023
positive regulation of secretion by cell	GO:1903532	114	0.023
ph reduction	GO:0045851	8	0.023
glycosyl compound catabolic process	GO:1901658	206	0.023
positive regulation of bone remodeling	GO:0046852	13	0.023
positive regulation of kinase activity	GO:0033674	155	0.023
regulation of protein kinase activity	GO:0045859	232	0.023
ribonucleotide metabolic process	GO:0009259	291	0.023
protein modification by small protein conjugation	GO:0032446	187	0.023
steroid metabolic process	GO:0008202	119	0.023
cognition	GO:0050890	149	0.023
antigen processing and presentation of exogenous peptide antigen	GO:0002478	21	0.023
purine nucleoside catabolic process	GO:0006152	205	0.023
cellular response to x ray	GO:0071481	2	0.022
negative regulation of immune system process	GO:0002683	209	0.022
leukocyte homeostasis	GO:0001776	79	0.022
heart contraction	GO:0060047	93	0.022
regulation of protein catabolic process	GO:0042176	108	0.022
lung development	GO:0030324	164	0.022
nuclear transport	GO:0051169	139	0.022
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.022
cellular macromolecule catabolic process	GO:0044265	206	0.022
leukocyte mediated cytotoxicity	GO:0001909	62	0.022
locomotory behavior	GO:0007626	195	0.022
interleukin 17 production	GO:0032620	11	0.021
regulation of membrane potential	GO:0042391	192	0.021
skeletal muscle organ development	GO:0060538	163	0.021
male gamete generation	GO:0048232	285	0.021
phagocytosis	GO:0006909	66	0.021
photoreceptor cell differentiation	GO:0046530	52	0.021
zinc ion transport	GO:0006829	12	0.021
nuclear division	GO:0000280	158	0.021
regulation of cell migration	GO:0030334	219	0.021
response to oxygen radical	GO:0000305	16	0.021
peptide metabolic process	GO:0006518	46	0.021
regulation of proteolysis	GO:0030162	164	0.021
forebrain development	GO:0030900	302	0.021
cell type specific apoptotic process	GO:0097285	268	0.021
regulation of t cell differentiation	GO:0045580	83	0.021
cell fate commitment	GO:0045165	210	0.021
carbohydrate metabolic process	GO:0005975	230	0.020
calcium ion transport	GO:0006816	159	0.020
negative regulation of homeostatic process	GO:0032845	71	0.020
regulation of blood pressure	GO:0008217	93	0.020
positive regulation of nitric oxide biosynthetic process	GO:0045429	14	0.020
positive regulation of endocytosis	GO:0045807	42	0.020
positive regulation of phagocytosis engulfment	GO:0060100	3	0.020
response to decreased oxygen levels	GO:0036293	59	0.020
regulation of intracellular transport	GO:0032386	159	0.020
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.020
sequestering of metal ion	GO:0051238	19	0.020
response to steroid hormone	GO:0048545	56	0.020
adult behavior	GO:0030534	135	0.020
maintenance of location	GO:0051235	89	0.019
response to arsenic containing substance	GO:0046685	5	0.019
body fluid secretion	GO:0007589	53	0.019
organic acid biosynthetic process	GO:0016053	86	0.019
respiratory system development	GO:0060541	190	0.019
nucleoside phosphate catabolic process	GO:1901292	222	0.019
macrophage activation	GO:0042116	27	0.019
glucose transport	GO:0015758	56	0.019
nucleoside catabolic process	GO:0009164	206	0.019
mitochondrion organization	GO:0007005	134	0.019
wound healing involved in inflammatory response	GO:0002246	4	0.019
antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway	GO:0002488	2	0.019
nucleoside triphosphate catabolic process	GO:0009143	205	0.019
multi multicellular organism process	GO:0044706	109	0.019
synaptic transmission	GO:0007268	329	0.019
visual perception	GO:0007601	52	0.019
defense response to other organism	GO:0098542	197	0.019
exosomal secretion	GO:1990182	1	0.018
regulation of endocytosis	GO:0030100	69	0.018
peptide transport	GO:0015833	133	0.018
regulation of lipid metabolic process	GO:0019216	118	0.018
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.018
positive regulation of intrinsic apoptotic signaling pathway in response to dna damage	GO:1902231	6	0.018
regulation of glucose metabolic process	GO:0010906	60	0.018
positive regulation of cellular amine metabolic process	GO:0033240	5	0.018
neuron apoptotic process	GO:0051402	142	0.018
anatomical structure homeostasis	GO:0060249	145	0.018
nucleoside metabolic process	GO:0009116	246	0.018
protein import into nucleus translocation	GO:0000060	12	0.018
cerebellar purkinje cell layer development	GO:0021680	26	0.018
amide transport	GO:0042886	138	0.018
positive regulation of leukocyte proliferation	GO:0070665	73	0.018
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.018
fatty acid metabolic process	GO:0006631	121	0.018
positive regulation of natural killer cell mediated cytotoxicity	GO:0045954	16	0.018
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.018
positive regulation of hormone secretion	GO:0046887	38	0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.017
sterol homeostasis	GO:0055092	45	0.017
regulation of transmembrane transport	GO:0034762	128	0.017
hormone secretion	GO:0046879	128	0.017
cellular response to oxygen radical	GO:0071450	14	0.017
antigen processing and presentation of exogenous peptide antigen via mhc class i	GO:0042590	6	0.017
mapk cascade	GO:0000165	281	0.017
regulation of lymphocyte proliferation	GO:0050670	117	0.016
lipid catabolic process	GO:0016042	69	0.016
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.016
organophosphate catabolic process	GO:0046434	232	0.016
purine nucleotide metabolic process	GO:0006163	302	0.016
positive regulation of secretion	GO:0051047	130	0.016
regulation of myeloid cell differentiation	GO:0045637	96	0.016
wnt signaling pathway	GO:0016055	188	0.016
response to reactive oxygen species	GO:0000302	56	0.016
alpha beta t cell activation involved in immune response	GO:0002287	31	0.016
positive regulation of growth	GO:0045927	104	0.016
positive regulation of protein phosphorylation	GO:0001934	242	0.016
lipid homeostasis	GO:0055088	63	0.016
atp metabolic process	GO:0046034	75	0.016
fibrinolysis	GO:0042730	3	0.016
regulation of cellular component size	GO:0032535	121	0.016
regulation of peptide hormone secretion	GO:0090276	75	0.016
glucan metabolic process	GO:0044042	32	0.016
tissue remodeling	GO:0048771	102	0.015
regulation of cell cycle	GO:0051726	281	0.015
purine ribonucleoside catabolic process	GO:0046130	205	0.015
neuron projection guidance	GO:0097485	141	0.015
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap dependent	GO:0002485	3	0.015
intracellular ph reduction	GO:0051452	6	0.015
negative regulation of cellular protein metabolic process	GO:0032269	247	0.015
cellular calcium ion homeostasis	GO:0006874	119	0.015
regulation of cardiac muscle cell membrane potential	GO:0086036	3	0.015
response to superoxide	GO:0000303	16	0.015
basic amino acid transport	GO:0015802	6	0.014
purine ribonucleotide metabolic process	GO:0009150	290	0.014
peptide secretion	GO:0002790	114	0.014
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.014
regulation of endopeptidase activity	GO:0052548	89	0.014
regulation of cytoplasmic transport	GO:1903649	112	0.014
carbohydrate homeostasis	GO:0033500	128	0.014
action potential	GO:0001508	78	0.014
negative regulation of cell activation	GO:0050866	111	0.014
epidermis development	GO:0008544	187	0.014
gliogenesis	GO:0042063	141	0.014
intracellular mrna localization	GO:0008298	4	0.014
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.014
response to nicotine	GO:0035094	6	0.014
regulation of cellular protein catabolic process	GO:1903362	61	0.014
mitotic cell cycle	GO:0000278	195	0.014
neural tube formation	GO:0001841	108	0.014
b cell differentiation	GO:0030183	78	0.014
phospholipid metabolic process	GO:0006644	87	0.014
g protein coupled receptor signaling pathway	GO:0007186	243	0.014
nucleoside phosphate metabolic process	GO:0006753	338	0.014
small gtpase mediated signal transduction	GO:0007264	97	0.014
alcohol metabolic process	GO:0006066	116	0.014
cellular response to prostaglandin stimulus	GO:0071379	2	0.014
zygotic determination of anterior posterior axis embryo	GO:0007354	3	0.014
cellular nitrogen compound catabolic process	GO:0044270	280	0.014
regulation of protein serine threonine kinase activity	GO:0071900	157	0.014
sterol metabolic process	GO:0016125	58	0.014
regulation of neuron differentiation	GO:0045664	281	0.014
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.014
neural tube closure	GO:0001843	90	0.013
lipid transport	GO:0006869	98	0.013
carbohydrate derivative catabolic process	GO:1901136	231	0.013
regulation of receptor activity	GO:0010469	41	0.013
negative regulation of neuron death	GO:1901215	98	0.013
monosaccharide transport	GO:0015749	58	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.013
response to nutrient levels	GO:0031667	109	0.013
cellular carbohydrate metabolic process	GO:0044262	119	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.013
sensory perception of light stimulus	GO:0050953	54	0.013
acylglycerol metabolic process	GO:0006639	55	0.013
organophosphate biosynthetic process	GO:0090407	122	0.013
embryonic epithelial tube formation	GO:0001838	130	0.013

Slc40a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
inherited metabolic disorder	DOID:655	0.659	Human
disease of metabolism	DOID:0014667	0.659	Human
metal metabolism disorder	DOID:896	0.659	Human
anemia	DOID:2355	0.559
disease of anatomical entity	DOID:7	0.559
immune system disease	DOID:2914	0.559
hematopoietic system disease	DOID:74	0.559
normocytic anemia	DOID:720	0.357
acquired metabolic disease	DOID:0060158	0.245
integumentary system disease	DOID:16	0.201
nervous system disease	DOID:863	0.184
central nervous system disease	DOID:331	0.184
disease of mental health	DOID:150	0.160
skin disease	DOID:37	0.081
dementia	DOID:1307	0.077
neurodegenerative disease	DOID:1289	0.077
alzheimer s disease	DOID:10652	0.077
tauopathy	DOID:680	0.077
cognitive disorder	DOID:1561	0.077
musculoskeletal system disease	DOID:17	0.023
connective tissue disease	DOID:65	0.023
hemolytic anemia	DOID:583	0.022
porphyria	DOID:13268	0.020
acute porphyria	DOID:3133	0.016
cardiovascular system disease	DOID:1287	0.015

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