IMP: Integrative Multi-species Prediction

Mus musculus

22 known processes

Figf

c-fos induced growth factor

(Aliases: Vegfd,AI325264,VEGF-D)

Entrez: 14205
Ensembl: ENSMUSG00000031380
UniProtKB: P97946

Process Predictions
Disease Predictions

Figf biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of peptidase activity	GO:0052547	96	0.297
regulation of cell adhesion	GO:0030155	154	0.264	Mouse
regulation of removal of superoxide radicals	GO:2000121	4	0.261
positive regulation of cell adhesion	GO:0045785	80	0.237	Mouse
respiratory system development	GO:0060541	190	0.230	Mouse
cellular ketone metabolic process	GO:0042180	84	0.228
cellular lipid metabolic process	GO:0044255	323	0.218
cellular response to growth factor stimulus	GO:0071363	197	0.216	Mouse Rat
elastic fiber assembly	GO:0048251	4	0.207
cell substrate adhesion	GO:0031589	130	0.198	Mouse
skeletal system development	GO:0001501	356	0.179
regulation of proteolysis	GO:0030162	164	0.166
respiratory tube development	GO:0030323	167	0.158	Mouse
cell adhesion	GO:0007155	329	0.149	Mouse
response to oxidative stress	GO:0006979	123	0.148
cellular response to oxidative stress	GO:0034599	76	0.142
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.140
epidermis development	GO:0008544	187	0.137	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.135
extracellular matrix organization	GO:0030198	147	0.129
positive regulation of proteolysis	GO:0045862	85	0.128
positive regulation of cellular amine metabolic process	GO:0033240	5	0.119
reactive oxygen species metabolic process	GO:0072593	84	0.118
morphogenesis of a branching structure	GO:0001763	203	0.117	Mouse
multicellular organismal homeostasis	GO:0048871	164	0.115	Mouse
compound eye development	GO:0048749	1	0.115
response to organic cyclic compound	GO:0014070	198	0.111
lung development	GO:0030324	164	0.109	Mouse
apoptotic signaling pathway	GO:0097190	306	0.107	Mouse
sensory perception	GO:0007600	245	0.104
positive regulation of mapk cascade	GO:0043410	170	0.103	Mouse
transmembrane transport	GO:0055085	412	0.102
response to growth factor	GO:0070848	198	0.100	Mouse Rat
epithelial tube morphogenesis	GO:0060562	303	0.098	Mouse Fly
extracellular structure organization	GO:0043062	148	0.097
response to hypoxia	GO:0001666	58	0.095	Rat
urogenital system development	GO:0001655	261	0.095	Mouse Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.094
amine metabolic process	GO:0009308	45	0.090
regulation of cellular amino acid metabolic process	GO:0006521	5	0.088
skeletal system morphogenesis	GO:0048705	203	0.087
regulation of system process	GO:0044057	200	0.087	Mouse
regulation of membrane potential	GO:0042391	192	0.086
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.086	Mouse
response to organonitrogen compound	GO:0010243	246	0.084
oxidation reduction process	GO:0055114	342	0.083
connective tissue development	GO:0061448	179	0.082	Mouse
regulation of actin filament based process	GO:0032970	99	0.082
ossification	GO:0001503	216	0.081
hormone secretion	GO:0046879	128	0.080
regulation of organelle organization	GO:0033043	289	0.079
regulation of apoptotic signaling pathway	GO:2001233	197	0.078	Mouse
calcium ion homeostasis	GO:0055074	127	0.076
regulation of cellular amine metabolic process	GO:0033238	20	0.075
positive regulation of programmed cell death	GO:0043068	218	0.074
axonogenesis	GO:0007409	274	0.073	Mouse
tissue homeostasis	GO:0001894	115	0.071	Mouse
macromolecule catabolic process	GO:0009057	281	0.071
morphogenesis of embryonic epithelium	GO:0016331	159	0.071	Mouse
inflammatory response	GO:0006954	244	0.070
cellular amine metabolic process	GO:0044106	44	0.069
regulation of hydrolase activity	GO:0051336	246	0.069
anatomical structure homeostasis	GO:0060249	145	0.069	Mouse
regulation of cytokine production	GO:0001817	266	0.068	Rat
response to radiation	GO:0009314	165	0.068	Fly
developmental programmed cell death	GO:0010623	41	0.068
hair follicle development	GO:0001942	85	0.068	Mouse
regulation of kinase activity	GO:0043549	249	0.067
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.067
positive regulation of peptidase activity	GO:0010952	49	0.067
cation transport	GO:0006812	399	0.066
appendage development	GO:0048736	166	0.066
positive regulation of cell death	GO:0010942	224	0.066
response to molecule of bacterial origin	GO:0002237	143	0.066
cytokine production	GO:0001816	319	0.063	Rat
regulation of cell motility	GO:2000145	236	0.063	Mouse
positive regulation of angiogenesis	GO:0045766	46	0.063	Mouse
peptidyl amino acid modification	GO:0018193	336	0.063	Mouse
regulation of cell cycle	GO:0051726	281	0.062	Mouse
blood vessel morphogenesis	GO:0048514	285	0.062	Zebrafish Mouse
fat cell differentiation	GO:0045444	160	0.062
kidney development	GO:0001822	213	0.060	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.059	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.059
cellular response to acid chemical	GO:0071229	68	0.059
branching involved in salivary gland morphogenesis	GO:0060445	26	0.057	Mouse
positive regulation of cell migration	GO:0030335	109	0.056	Mouse
positive regulation of nervous system development	GO:0051962	221	0.055	Mouse
cell chemotaxis	GO:0060326	81	0.055
hematopoietic progenitor cell differentiation	GO:0002244	143	0.055	Mouse
negative regulation of immune system process	GO:0002683	209	0.055
regulation of cellular component biogenesis	GO:0044087	181	0.054
cellular amino acid metabolic process	GO:0006520	103	0.053
sensory perception of sound	GO:0007605	97	0.052
positive regulation of cell substrate adhesion	GO:0010811	47	0.050	Mouse
regulation of secretion by cell	GO:1903530	249	0.050
cell junction organization	GO:0034330	77	0.049
regulation of cell projection organization	GO:0031344	206	0.049	Mouse
regulation of anatomical structure size	GO:0090066	178	0.049	Mouse
positive regulation of hydrolase activity	GO:0051345	148	0.049
regulation of cytoskeleton organization	GO:0051493	122	0.048
response to acid chemical	GO:0001101	111	0.048
circulatory system process	GO:0003013	197	0.047	Zebrafish Mouse
rhythmic process	GO:0048511	174	0.047	Mouse
epithelial cell migration	GO:0010631	63	0.047	Mouse Fly
regulation of ossification	GO:0030278	112	0.047
regulation of hormone levels	GO:0010817	211	0.047
cellular response to cytokine stimulus	GO:0071345	189	0.047
drug metabolic process	GO:0017144	4	0.045
regulation of cell migration	GO:0030334	219	0.045	Mouse
regulation of angiogenesis	GO:0045765	81	0.045	Mouse
intrinsic apoptotic signaling pathway	GO:0097193	132	0.045
angiogenesis	GO:0001525	201	0.044	Mouse
antibacterial peptide biosynthetic process	GO:0002780	2	0.044
camera type eye development	GO:0043010	266	0.044	Mouse
negative regulation of ossification	GO:0030279	49	0.044
positive regulation of protein modification process	GO:0031401	299	0.043	Mouse
regulation of secretion	GO:0051046	274	0.043
leukocyte differentiation	GO:0002521	342	0.043
negative regulation of molecular function	GO:0044092	258	0.043
metanephric glomerular mesangium development	GO:0072223	3	0.043	Mouse
lipid biosynthetic process	GO:0008610	179	0.043
lung alveolus development	GO:0048286	45	0.042	Mouse
protein import	GO:0017038	101	0.042
cartilage development	GO:0051216	140	0.042
bone development	GO:0060348	120	0.041
canonical wnt signaling pathway	GO:0060070	130	0.041
spermatogenesis	GO:0007283	284	0.040
regulation of mitotic cell cycle	GO:0007346	126	0.040	Mouse
protein oligomerization	GO:0051259	67	0.040
stem cell differentiation	GO:0048863	268	0.040
membrane lipid metabolic process	GO:0006643	53	0.039
regulation of cell growth	GO:0001558	91	0.039	Mouse
cellular response to oxygen radical	GO:0071450	14	0.039
regulation of cellular ketone metabolic process	GO:0010565	66	0.039
chemotaxis	GO:0006935	247	0.039	Mouse
ameboidal type cell migration	GO:0001667	128	0.039	Mouse Fly
positive regulation of cell motility	GO:2000147	116	0.038	Mouse
myeloid cell differentiation	GO:0030099	233	0.038	Mouse
male gamete generation	GO:0048232	285	0.038
regulation of transferase activity	GO:0051338	263	0.038
dna metabolic process	GO:0006259	303	0.038
forebrain development	GO:0030900	302	0.038
single organismal cell cell adhesion	GO:0016337	131	0.038	Mouse
wound healing	GO:0042060	157	0.038
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.038	Mouse
protein catabolic process	GO:0030163	221	0.037
embryonic organ morphogenesis	GO:0048562	276	0.037
multi multicellular organism process	GO:0044706	109	0.037
bmp signaling pathway	GO:0030509	93	0.036
protein secretion	GO:0009306	111	0.036
regulation of actin cytoskeleton organization	GO:0032956	84	0.036
myeloid cell homeostasis	GO:0002262	114	0.036	Mouse
trachea cartilage morphogenesis	GO:0060535	4	0.036
digestive tract morphogenesis	GO:0048546	147	0.036	Fly
chondrocyte differentiation	GO:0002062	72	0.036
nitrogen compound transport	GO:0071705	271	0.036
cellular response to dna damage stimulus	GO:0006974	207	0.035
membrane organization	GO:0061024	245	0.035
vascular process in circulatory system	GO:0003018	62	0.035	Mouse
retinal blood vessel morphogenesis	GO:0061304	3	0.035
branching morphogenesis of an epithelial tube	GO:0048754	159	0.035	Mouse
myeloid leukocyte migration	GO:0097529	57	0.035
epithelial cell proliferation	GO:0050673	174	0.035	Mouse
positive regulation of homeostatic process	GO:0032846	64	0.035
morphogenesis of a branching epithelium	GO:0061138	193	0.035	Mouse
leukocyte migration	GO:0050900	124	0.035
response to amino acid	GO:0043200	37	0.035
peptidyl tyrosine phosphorylation	GO:0018108	143	0.035	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.034
cellular amide metabolic process	GO:0043603	58	0.034
gland development	GO:0048732	330	0.034	Mouse Fly
regulation of protein kinase activity	GO:0045859	232	0.034
neuron migration	GO:0001764	122	0.034
hindbrain development	GO:0030902	128	0.034
skin development	GO:0043588	220	0.033	Mouse
protein maturation	GO:0051604	176	0.033
response to inorganic substance	GO:0010035	96	0.033
negative regulation of intracellular signal transduction	GO:1902532	167	0.033
regulation of homeostatic process	GO:0032844	182	0.033
appendage morphogenesis	GO:0035107	149	0.033
peptidyl tyrosine modification	GO:0018212	145	0.033	Mouse
locomotory behavior	GO:0007626	195	0.033
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.033
developmental maturation	GO:0021700	193	0.033	Mouse
muscle tissue development	GO:0060537	308	0.032	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.032
regulation of organ morphogenesis	GO:2000027	144	0.032	Mouse
response to superoxide	GO:0000303	16	0.032
t cell activation	GO:0042110	289	0.032
regulation of epithelial cell proliferation	GO:0050678	141	0.032	Mouse
bone mineralization	GO:0030282	54	0.032
regulation of tube size	GO:0035150	57	0.032
second messenger mediated signaling	GO:0019932	73	0.031
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.031	Mouse Rat
nuclear division	GO:0000280	158	0.031
regulation of endopeptidase activity	GO:0052548	89	0.031
negative regulation of phosphorus metabolic process	GO:0010563	184	0.030
divalent inorganic cation transport	GO:0072511	178	0.030
lymphocyte differentiation	GO:0030098	242	0.030
nuclear transport	GO:0051169	139	0.030
positive regulation of kinase activity	GO:0033674	155	0.030
regulation of stem cell proliferation	GO:0072091	78	0.030	Mouse
cellular homeostasis	GO:0019725	240	0.030
cytokine mediated signaling pathway	GO:0019221	115	0.030
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.030
peptidyl serine phosphorylation	GO:0018105	74	0.030
development of primary sexual characteristics	GO:0045137	143	0.030	Mouse
female gonad development	GO:0008585	71	0.030	Mouse
cellular response to amino acid stimulus	GO:0071230	29	0.029
response to oxygen levels	GO:0070482	62	0.029	Rat
intracellular protein transport	GO:0006886	204	0.029
actin cytoskeleton organization	GO:0030036	220	0.029	Mouse
negative regulation of hormone biosynthetic process	GO:0032353	4	0.029
limb morphogenesis	GO:0035108	149	0.029
cation homeostasis	GO:0055080	212	0.029
sensory perception of mechanical stimulus	GO:0050954	107	0.028
axon guidance	GO:0007411	141	0.028	Mouse
production of molecular mediator of immune response	GO:0002440	103	0.028
regulation of metal ion transport	GO:0010959	106	0.028
organic hydroxy compound metabolic process	GO:1901615	203	0.028
embryonic appendage morphogenesis	GO:0035113	126	0.028
female sex differentiation	GO:0046660	84	0.028	Mouse
germ cell development	GO:0007281	185	0.027	Fly
cellular response to superoxide	GO:0071451	14	0.027
regulation of chemotaxis	GO:0050920	53	0.027	Mouse
cofactor metabolic process	GO:0051186	80	0.027
leukocyte chemotaxis	GO:0030595	69	0.027
divalent metal ion transport	GO:0070838	172	0.027
organonitrogen compound biosynthetic process	GO:1901566	192	0.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.027
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.027
positive regulation of epithelial cell proliferation	GO:0050679	68	0.027	Mouse
smooth muscle cell chemotaxis	GO:0071670	2	0.027
regulation of ion transport	GO:0043269	215	0.027
immune response activating signal transduction	GO:0002757	116	0.027
endomembrane system organization	GO:0010256	147	0.026
regulation of transmembrane transport	GO:0034762	128	0.026
carbohydrate homeostasis	GO:0033500	128	0.026
g protein coupled receptor signaling pathway	GO:0007186	243	0.026
blood coagulation	GO:0007596	76	0.026
cell division	GO:0051301	120	0.026
granulocyte migration	GO:0097530	43	0.026
removal of superoxide radicals	GO:0019430	12	0.026
response to steroid hormone	GO:0048545	56	0.026
protein kinase b signaling	GO:0043491	74	0.026	Mouse
response to oxygen radical	GO:0000305	16	0.026
positive regulation of endopeptidase activity	GO:0010950	43	0.026
positive regulation of bone remodeling	GO:0046852	13	0.026
regulation of protein kinase b signaling	GO:0051896	56	0.026	Mouse
regulation of lipid metabolic process	GO:0019216	118	0.026
homeostasis of number of cells	GO:0048872	210	0.025	Mouse
peptide metabolic process	GO:0006518	46	0.025
positive regulation of dna biosynthetic process	GO:2000573	4	0.025
microtubule based process	GO:0007017	236	0.025
cellular ion homeostasis	GO:0006873	165	0.025
sodium ion transport	GO:0006814	73	0.025
regulation of cartilage development	GO:0061035	44	0.025
salivary gland development	GO:0007431	37	0.025	Mouse Fly
immune effector process	GO:0002252	321	0.025
regulation of body fluid levels	GO:0050878	162	0.024	Mouse
regulation of protein serine threonine kinase activity	GO:0071900	157	0.024
response to alcohol	GO:0097305	48	0.024
amide transport	GO:0042886	138	0.024
inorganic ion transmembrane transport	GO:0098660	234	0.024
positive regulation of cell cycle	GO:0045787	92	0.023	Mouse
regulation of tissue remodeling	GO:0034103	38	0.023
aromatic compound catabolic process	GO:0019439	286	0.023
apoptotic process involved in morphogenesis	GO:0060561	25	0.023
organophosphate biosynthetic process	GO:0090407	122	0.023
sphingolipid metabolic process	GO:0006665	45	0.023
regulation of cellular component size	GO:0032535	121	0.023	Mouse
positive regulation of antimicrobial peptide production	GO:0002225	1	0.023
innate immune response	GO:0045087	157	0.023
tissue remodeling	GO:0048771	102	0.023
regulation of bmp signaling pathway	GO:0030510	60	0.023
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.023	Mouse
regulation of cell cycle process	GO:0010564	160	0.023
microtubule cytoskeleton organization	GO:0000226	157	0.022
negative regulation of bone mineralization	GO:0030502	10	0.022
ion transmembrane transport	GO:0034220	361	0.022
positive regulation of protein kinase activity	GO:0045860	144	0.022
response to lipopolysaccharide	GO:0032496	128	0.022
protein modification by small protein conjugation	GO:0032446	187	0.022
cell cell junction organization	GO:0045216	72	0.022
muscle contraction	GO:0006936	101	0.022	Mouse
organic cyclic compound catabolic process	GO:1901361	295	0.022
cellular response to external stimulus	GO:0071496	88	0.022
metencephalon development	GO:0022037	89	0.021
neural tube formation	GO:0001841	108	0.021
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.021
regulation of ion transmembrane transport	GO:0034765	119	0.021
blood circulation	GO:0008015	195	0.021	Zebrafish Mouse
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.021
positive regulation of secretion	GO:0051047	130	0.021
positive regulation of protein kinase b signaling	GO:0051897	32	0.021	Mouse
regulation of cell substrate adhesion	GO:0010810	73	0.021	Mouse
endochondral bone growth	GO:0003416	19	0.021
apoptotic process involved in development	GO:1902742	28	0.021
regionalization	GO:0003002	337	0.021
neuronal action potential	GO:0019228	54	0.021
renal system vasculature development	GO:0061437	15	0.021	Mouse
regulation of muscle system process	GO:0090257	80	0.020
negative regulation of epithelial cell proliferation	GO:0050680	64	0.020
regulation of response to oxidative stress	GO:1902882	19	0.020
bone resorption	GO:0045453	38	0.020
response to decreased oxygen levels	GO:0036293	59	0.020	Rat
mapk cascade	GO:0000165	281	0.020	Mouse
notch signaling pathway	GO:0007219	71	0.020
negative regulation of growth	GO:0045926	99	0.020
reactive oxygen species biosynthetic process	GO:1903409	8	0.020
fertilization	GO:0009566	127	0.020
cellular macromolecule catabolic process	GO:0044265	206	0.020
regulation of cellular response to stress	GO:0080135	159	0.020
antimicrobial peptide biosynthetic process	GO:0002777	2	0.020
tube formation	GO:0035148	140	0.020
negative regulation of phosphate metabolic process	GO:0045936	184	0.020
negative regulation of protein metabolic process	GO:0051248	282	0.020
single organism cell adhesion	GO:0098602	156	0.019	Mouse
kidney morphogenesis	GO:0060993	83	0.019	Mouse
lateral inhibition	GO:0046331	1	0.019
organelle fission	GO:0048285	170	0.019
mitotic cell cycle process	GO:1903047	159	0.019
negative regulation of wnt signaling pathway	GO:0030178	73	0.019
granulocyte chemotaxis	GO:0071621	39	0.019
cellular response to hormone stimulus	GO:0032870	150	0.019
regulation of phospholipase a2 activity	GO:0032429	3	0.019
small gtpase mediated signal transduction	GO:0007264	97	0.019
regulation of cellular response to oxidative stress	GO:1900407	19	0.019
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.019
superoxide metabolic process	GO:0006801	27	0.019
reactive nitrogen species metabolic process	GO:2001057	0	0.019
tissue migration	GO:0090130	68	0.019	Mouse Fly
antimicrobial peptide production	GO:0002775	2	0.019
dendrite development	GO:0016358	115	0.019
developmental growth involved in morphogenesis	GO:0060560	138	0.019	Mouse
nuclear import	GO:0051170	95	0.019
nucleoside phosphate metabolic process	GO:0006753	338	0.019
asymmetric stem cell division	GO:0098722	3	0.019
protein processing	GO:0016485	163	0.018
fat soluble vitamin biosynthetic process	GO:0042362	4	0.018
renal system development	GO:0072001	225	0.018	Mouse Fly
regulation of muscle contraction	GO:0006937	49	0.018
regulation of blood vessel size	GO:0050880	56	0.018
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	19	0.018
sensory organ morphogenesis	GO:0090596	242	0.018	Mouse
positive regulation of phospholipase activity	GO:0010518	3	0.018
calcium ion dependent exocytosis	GO:0017156	35	0.018
regulation of nucleocytoplasmic transport	GO:0046822	73	0.018
cellular response to organic cyclic compound	GO:0071407	87	0.018
cellular response to extracellular stimulus	GO:0031668	81	0.018
embryonic skeletal system development	GO:0048706	120	0.018
positive regulation of secretion by cell	GO:1903532	114	0.018
cell migration involved in vasculogenesis	GO:0035441	2	0.018
limb development	GO:0060173	166	0.018
single fertilization	GO:0007338	82	0.018
regulation of epithelial cell migration	GO:0010632	35	0.018
negative regulation of cell proliferation	GO:0008285	296	0.018	Mouse
skeletal muscle organ development	GO:0060538	163	0.018
divalent inorganic cation homeostasis	GO:0072507	138	0.018
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.018	Mouse
negative regulation of lymphocyte activation	GO:0051250	91	0.018
regulation of lymphocyte activation	GO:0051249	240	0.018
b cell activation	GO:0042113	161	0.018
cell type specific apoptotic process	GO:0097285	268	0.018	Mouse
positive regulation of cytokine production	GO:0001819	174	0.018	Rat
regulation of ketone biosynthetic process	GO:0010566	2	0.018
response to reactive oxygen species	GO:0000302	56	0.018
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.018
calcium ion transport	GO:0006816	159	0.017
wnt signaling pathway	GO:0016055	188	0.017
cell fate commitment	GO:0045165	210	0.017
organism emergence from protective structure	GO:0071684	4	0.017
neuron projection guidance	GO:0097485	141	0.017	Mouse
positive regulation of cellular component biogenesis	GO:0044089	94	0.017
negative regulation of cellular component organization	GO:0051129	194	0.017
peptidyl serine modification	GO:0018209	83	0.017
single organism nuclear import	GO:1902593	95	0.017
platelet derived growth factor receptor beta signaling pathway	GO:0035791	4	0.017
negative regulation of endothelial cell migration	GO:0010596	4	0.017
negative regulation of bmp signaling pathway	GO:0030514	35	0.017
nucleobase containing small molecule metabolic process	GO:0055086	352	0.017
regulation of vasculature development	GO:1901342	88	0.017	Mouse
growth plate cartilage development	GO:0003417	14	0.017
placenta blood vessel development	GO:0060674	31	0.017
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.017
respiratory system process	GO:0003016	25	0.017
pallium development	GO:0021543	120	0.017
regulation of canonical wnt signaling pathway	GO:0060828	82	0.017
spermatid differentiation	GO:0048515	115	0.017
response to endoplasmic reticulum stress	GO:0034976	53	0.017
positive regulation of organelle organization	GO:0010638	128	0.017
meiotic nuclear division	GO:0007126	115	0.017
carbohydrate metabolic process	GO:0005975	230	0.016	Mouse
neuron projection extension	GO:1990138	64	0.016	Mouse
placenta development	GO:0001890	140	0.016	Mouse
peptide transport	GO:0015833	133	0.016
metal ion homeostasis	GO:0055065	189	0.016
mature dendritic cell differentiation	GO:0097029	3	0.016
gonad development	GO:0008406	141	0.016	Mouse
protein localization to plasma membrane	GO:0072659	57	0.016
regulation of neuron differentiation	GO:0045664	281	0.016	Mouse
forebrain cell migration	GO:0021885	58	0.016
inorganic cation transmembrane transport	GO:0098662	207	0.016
adult behavior	GO:0030534	135	0.016
sensory perception of pain	GO:0019233	47	0.016
activation of immune response	GO:0002253	138	0.016
antibacterial peptide production	GO:0002778	2	0.016
regulation of establishment of protein localization	GO:0070201	181	0.016
regulation of b cell activation	GO:0050864	81	0.016
positive regulation of mitotic cell cycle	GO:0045931	41	0.016	Mouse
smooth muscle contraction	GO:0006939	44	0.016
development of primary female sexual characteristics	GO:0046545	73	0.016	Mouse
response to extracellular stimulus	GO:0009991	127	0.016
protein targeting	GO:0006605	143	0.016
cellular response to organonitrogen compound	GO:0071417	145	0.016
regulation of response to wounding	GO:1903034	189	0.016
substrate dependent cell migration	GO:0006929	18	0.016	Mouse
retina development in camera type eye	GO:0060041	119	0.015
salivary gland morphogenesis	GO:0007435	33	0.015	Mouse Fly
transmission of nerve impulse	GO:0019226	76	0.015
nucleoside catabolic process	GO:0009164	206	0.015
bone morphogenesis	GO:0060349	78	0.015
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.015
glycerolipid metabolic process	GO:0046486	122	0.015
i kappab kinase nf kappab signaling	GO:0007249	85	0.015
vitamin d biosynthetic process	GO:0042368	3	0.015
physiological cardiac muscle hypertrophy	GO:0003301	3	0.015
positive regulation of transferase activity	GO:0051347	167	0.015
heterocycle catabolic process	GO:0046700	280	0.015
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.015
endocytosis	GO:0006897	168	0.015
regulation of mapk cascade	GO:0043408	248	0.015	Mouse
regulation of fat cell differentiation	GO:0045598	81	0.015
cellular response to lipid	GO:0071396	145	0.015
somatic stem cell division	GO:0048103	19	0.015
steroid metabolic process	GO:0008202	119	0.015
exocytosis	GO:0006887	121	0.015
cytoplasmic transport	GO:0016482	234	0.015
response to peptide	GO:1901652	136	0.015
palate development	GO:0060021	76	0.015
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.015	Fly
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.015
mitotic cell cycle	GO:0000278	195	0.015	Mouse
regulation of blood pressure	GO:0008217	93	0.015	Mouse
endothelial cell migration	GO:0043542	44	0.015	Mouse
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.015
sulfur compound metabolic process	GO:0006790	100	0.015
meiotic cell cycle process	GO:1903046	77	0.014
cellular calcium ion homeostasis	GO:0006874	119	0.014
heart morphogenesis	GO:0003007	178	0.014	Mouse
nucleocytoplasmic transport	GO:0006913	139	0.014
regulation of nucleotide metabolic process	GO:0006140	169	0.014
receptor mediated endocytosis	GO:0006898	51	0.014
interleukin 8 production	GO:0032637	4	0.014
peptide secretion	GO:0002790	114	0.014
exocrine system development	GO:0035272	45	0.014	Mouse Fly
epithelial cell development	GO:0002064	159	0.014	Mouse Fly
protein import into nucleus	GO:0006606	95	0.014
multicellular organismal signaling	GO:0035637	91	0.014
establishment of protein localization to membrane	GO:0090150	54	0.014
embryonic placenta development	GO:0001892	98	0.014	Mouse
leukocyte homeostasis	GO:0001776	79	0.014
protein modification by small protein conjugation or removal	GO:0070647	207	0.014
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.014
nucleotide catabolic process	GO:0009166	217	0.014
response to estrogen	GO:0043627	24	0.014
response to light stimulus	GO:0009416	135	0.014
cellular response to stem cell factor stimulus	GO:0036216	3	0.014
establishment of organelle localization	GO:0051656	122	0.014
dna endoreduplication	GO:0042023	4	0.014
regulation of calcium ion transport	GO:0051924	69	0.014
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.014
leukocyte apoptotic process	GO:0071887	71	0.014
body morphogenesis	GO:0010171	45	0.014
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.014	Mouse
retina vasculature development in camera type eye	GO:0061298	17	0.014
cellularization	GO:0007349	1	0.014
molting cycle	GO:0042303	90	0.014	Mouse
mitotic cytokinesis	GO:0000281	4	0.014
hair follicle morphogenesis	GO:0031069	29	0.014
negative regulation of cellular protein metabolic process	GO:0032269	247	0.014

Figf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.075
disease of anatomical entity	DOID:7	0.075
eye disease	DOID:5614	0.050
eye and adnexa disease	DOID:1492	0.050
sensory system disease	DOID:0050155	0.050
retinal disease	DOID:5679	0.040
retinal degeneration	DOID:8466	0.040
musculoskeletal system disease	DOID:17	0.038
muscular disease	DOID:0080000	0.038
muscle tissue disease	DOID:66	0.035
myopathy	DOID:423	0.035
muscular dystrophy	DOID:9884	0.035
immune system disease	DOID:2914	0.015
hematopoietic system disease	DOID:74	0.015

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