Mus musculus

224 known processes

Irf1

interferon regulatory factor 1

(Aliases: Irf-1,AU020929)

Irf1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to molecule of bacterial originGO:0071219830.971
Mouse
regulation of defense responseGO:00313472330.959
interspecies interaction between organismsGO:0044419830.954
Mouse
defense response to other organismGO:00985421970.946
defense response to bacteriumGO:00427421190.937
Mouse
cellular amino acid metabolic processGO:00065201030.920
cellular response to cytokine stimulusGO:00713451890.911
innate immune responseGO:00450871570.910
negative regulation of immune system processGO:00026832090.877
positive regulation of innate immune responseGO:0045089800.877
regulation of defense response to virus by hostGO:005069180.857
Mouse
regulation of cytokine productionGO:00018172660.850
negative regulation of interleukin 2 productionGO:003270380.841
regulation of innate immune responseGO:0045088910.823
cellular amine metabolic processGO:0044106440.821
defense response to virusGO:0051607680.810
cellular response to lipopolysaccharideGO:0071222770.810
Mouse
response to lipopolysaccharideGO:00324961280.807
Mouse
symbiosis encompassing mutualism through parasitismGO:0044403830.803
Mouse
amine metabolic processGO:0009308450.803
negative regulation of multi organism processGO:0043901680.801
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.770
Mouse
defense response to gram negative bacteriumGO:0050829280.764
defense response to gram positive bacteriumGO:0050830500.744
adaptive immune responseGO:00022501550.733
Mouse
regulation of cellular amine metabolic processGO:0033238200.731
negative regulation of protein metabolic processGO:00512482820.707
Mouse
t helper cell differentiationGO:0042093280.704
Mouse
antibacterial peptide productionGO:000277820.704
leukocyte differentiationGO:00025213420.702
response to protozoanGO:0001562280.698
Mouse
response to type i interferonGO:0034340120.697
Mouse
cellular response to dna damage stimulusGO:00069742070.692
defense response to protozoanGO:0042832250.687
Mouse
negative regulation of molecular functionGO:00440922580.686
immune response regulating signaling pathwayGO:00027641250.682
protein modification by small protein conjugation or removalGO:00706472070.681
cellular response to organonitrogen compoundGO:00714171450.669
response to molecule of bacterial originGO:00022371430.664
Mouse
negative regulation of defense responseGO:0031348770.659
Mouse
peptidyl amino acid modificationGO:00181933360.659
Mouse
antigen processing and presentationGO:0019882470.649
cellular response to lipidGO:00713961450.647
Mouse
t cell differentiationGO:00302171740.640
negative regulation of cell proliferationGO:00082852960.640
Mouse
regulation of tolerance induction dependent upon immune responseGO:000265210.637
protein ubiquitinationGO:00165671710.619
regulation of defense response to bacteriumGO:190042430.614
inflammatory responseGO:00069542440.612
alpha beta t cell differentiation involved in immune responseGO:0002293300.599
Mouse
negative regulation of protein modification processGO:00314001630.596
regulation of interleukin 2 productionGO:0032663280.587
immune effector processGO:00022523210.576
cytokine productionGO:00018163190.571
negative regulation of cell activationGO:00508661110.569
cytokine mediated signaling pathwayGO:00192211150.551
regulation of cytokine biosynthetic processGO:0042035590.544
purine ribonucleoside triphosphate metabolic processGO:00092052200.543
negative regulation of lymphocyte activationGO:0051250910.541
response to interferon gammaGO:0034341340.525
pattern recognition receptor signaling pathwayGO:0002221470.523
regulation of t cell mediated immunityGO:0002709340.518
positive regulation of adaptive immune responseGO:0002821610.512
i kappab kinase nf kappab signalingGO:0007249850.500
immunoglobulin mediated immune responseGO:0016064690.497
Mouse
production of molecular mediator of immune responseGO:00024401030.483
regulation of adaptive immune responseGO:0002819900.478
negative regulation of cytokine productionGO:0001818840.477
Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.471
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.463
Mouse
antimicrobial peptide productionGO:000277520.462
positive regulation of apoptotic processGO:00430652170.461
interleukin 1 beta productionGO:0032611300.457
carbohydrate derivative catabolic processGO:19011362310.455
regulation of cellular catabolic processGO:00313292420.440
peptidyl tyrosine phosphorylationGO:00181081430.431
regulation of leukocyte differentiationGO:19021051590.429
regulation of cellular amino acid metabolic processGO:000652150.423
positive regulation of peptidase activityGO:0010952490.422
regulation of myd88 independent toll like receptor signaling pathwayGO:003412710.422
Mouse
lymphocyte activation involved in immune responseGO:0002285930.421
Mouse
protein modification by small protein conjugationGO:00324461870.409
positive regulation of cell deathGO:00109422240.394
gland developmentGO:00487323300.394
Mouse
guanosine containing compound catabolic processGO:19010691440.387
regulation of lymphocyte mediated immunityGO:0002706840.386
heterocycle catabolic processGO:00467002800.385
cellular ketone metabolic processGO:0042180840.379
regulation of cytokine secretionGO:0050707610.376
glycosyl compound catabolic processGO:19016582060.374
regulation of antimicrobial humoral responseGO:000275930.367
negative regulation of t cell activationGO:0050868650.366
aromatic compound catabolic processGO:00194392860.365
regulation of t cell activationGO:00508631700.362
b cell activationGO:00421131610.362
negative regulation of immune effector processGO:0002698550.360
Mouse
negative regulation of natural killer cell mediated immunityGO:000271650.353
activation of innate immune responseGO:0002218560.349
negative regulation of protein phosphorylationGO:00019331260.343
regulation of lymphocyte proliferationGO:00506701170.338
positive regulation of programmed cell deathGO:00430682180.336
purine ribonucleoside catabolic processGO:00461302050.328
cellular amide metabolic processGO:0043603580.327
t cell mediated immunityGO:0002456500.327
regulation of response to woundingGO:19030341890.321
regulation of interferon gamma productionGO:0032649570.318
Mouse
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.317
positive regulation of defense responseGO:00313491240.316
gtp metabolic processGO:00460391440.314
lymphocyte mediated immunityGO:00024491390.314
Mouse
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.310
positive regulation of cytokine productionGO:00018191740.308
positive regulation of immune effector processGO:00026991070.302
leukocyte proliferationGO:00706611720.302
t cell proliferationGO:00420981200.300
positive regulation of hydrolase activityGO:00513451480.300
negative regulation of phosphorus metabolic processGO:00105631840.297
cellular response to interferon gammaGO:0071346250.294
leukocyte chemotaxisGO:0030595690.293
viral processGO:0016032410.291
epithelial cell proliferationGO:00506731740.288
Mouse
humoral immune responseGO:0006959570.286
somatic diversification of immunoglobulins involved in immune responseGO:0002208360.282
regulation of t cell proliferationGO:0042129920.281
regulation of response to biotic stimulusGO:0002831380.277
Mouse
regulation of type i interferon mediated signaling pathwayGO:006033870.274
Mouse
lymphocyte proliferationGO:00466511640.269
myeloid cell differentiationGO:00300992330.268
Mouse
positive regulation of cellular amine metabolic processGO:003324050.267
regulation of lymphocyte activationGO:00512492400.264
t cell activationGO:00421102890.263
positive regulation of interferon gamma productionGO:0032729390.256
Mouse
leukocyte activation involved in immune responseGO:00023661260.256
Mouse
cytokine metabolic processGO:0042107710.256
negative regulation of inflammatory responseGO:0050728610.255
glycosyl compound metabolic processGO:19016572460.254
interleukin 1 productionGO:0032612310.254
peptidyl tyrosine modificationGO:00182121450.252
type i interferon signaling pathwayGO:0060337100.250
Mouse
homeostasis of number of cellsGO:00488722100.250
antimicrobial peptide biosynthetic processGO:000277720.249
negative regulation of growthGO:0045926990.248
Mouse
positive regulation of t cell mediated cytotoxicityGO:0001916150.247
reactive oxygen species metabolic processGO:0072593840.245
negative regulation of growth of symbiont in hostGO:0044130190.245
Mouse
t cell activation involved in immune responseGO:0002286430.241
Mouse
regulation of cellular ketone metabolic processGO:0010565660.241
purine nucleoside triphosphate catabolic processGO:00091462030.240
cell activation involved in immune responseGO:00022631260.240
Mouse
regulation of defense response to virusGO:0050688180.237
Mouse
positive regulation of interleukin 1 secretionGO:0050716140.237
ribose phosphate metabolic processGO:00196932910.234
immune response activating signal transductionGO:00027571160.234
cellular response to tumor necrosis factorGO:0071356210.234
viral life cycleGO:0019058360.230
antibacterial peptide biosynthetic processGO:000278020.221
positive regulation of cellular amino acid metabolic processGO:004576430.220
cd4 positive alpha beta t cell differentiation involved in immune responseGO:0002294280.218
Mouse
nucleotide metabolic processGO:00091173320.216
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.215
macromolecule catabolic processGO:00090572810.215
positive regulation of protein modification processGO:00314012990.214
negative regulation of innate immune responseGO:0045824170.214
alpha beta t cell activation involved in immune responseGO:0002287310.211
Mouse
positive regulation of proteolysisGO:0045862850.208
regulation of autophagyGO:0010506300.204
b cell activation involved in immune responseGO:0002312500.202
cellular response to biotic stimulusGO:0071216920.201
Mouse
t helper 1 type immune responseGO:0042088250.198
muscle cell developmentGO:00550011330.197
programmed necrotic cell deathGO:0097300280.194
Mouse
nucleoside triphosphate metabolic processGO:00091412300.193
lymphocyte differentiationGO:00300982420.192
protein localization to nucleusGO:00345041210.192
positive regulation of antimicrobial peptide productionGO:000222510.190
nucleotide catabolic processGO:00091662170.186
cytokine biosynthetic processGO:0042089680.185
regulation of sequence specific dna binding transcription factor activityGO:00510901060.184
negative regulation of phosphorylationGO:00423261660.183
antibacterial humoral responseGO:001973180.181
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathwayGO:000248430.181
somatic recombination of immunoglobulin genes involved in immune responseGO:0002204360.178
somatic diversification of immunoglobulinsGO:0016445430.175
purine ribonucleoside triphosphate catabolic processGO:00092071990.175
small gtpase mediated signal transductionGO:0007264970.172
regulation of cell migrationGO:00303342190.172
interferon gamma productionGO:0032609670.171
Mouse
cytokine secretionGO:0050663720.171
organonitrogen compound catabolic processGO:19015652640.170
regulation of endopeptidase activityGO:0052548890.170
cellular response to type i interferonGO:0071357100.168
Mouse
cellular macromolecule catabolic processGO:00442652060.168
purine nucleotide catabolic processGO:00061952110.168
response to radiationGO:00093141650.167
regulation of cellular component biogenesisGO:00440871810.166
Mouse
negative regulation of cellular amine metabolic processGO:003323910.166
purine nucleoside triphosphate metabolic processGO:00091442260.163
regulation of epithelial cell proliferationGO:00506781410.163
regulation of leukocyte mediated immunityGO:00027031040.160
nucleoside phosphate catabolic processGO:19012922220.160
peptide metabolic processGO:0006518460.160
gtp catabolic processGO:00061841430.158
ribonucleoside triphosphate catabolic processGO:00092031990.157
myeloid leukocyte differentiationGO:00025731190.155
Mouse
guanosine containing compound metabolic processGO:19010681440.154
regulation of natural killer cell mediated cytotoxicityGO:0042269190.153
response to organic cyclic compoundGO:00140701980.153
Mouse
innate immune response activating signal transductionGO:0002758500.152
skin developmentGO:00435882200.152
Mouse
nucleoside phosphate metabolic processGO:00067533380.151
regulation of cell motilityGO:20001452360.150
negative regulation of cellular protein metabolic processGO:00322692470.150
cellular response to organic cyclic compoundGO:0071407870.150
negative regulation of t helper 2 cell differentiationGO:004562940.149
ras protein signal transductionGO:0007265770.148
carbohydrate metabolic processGO:00059752300.148
nucleobase containing small molecule metabolic processGO:00550863520.148
cellular nitrogen compound catabolic processGO:00442702800.148
response to tumor necrosis factorGO:0034612260.147
protein maturationGO:00516041760.146
dna metabolic processGO:00062593030.146
notch signaling pathwayGO:0007219710.146
organophosphate catabolic processGO:00464342320.145
negative regulation of phosphate metabolic processGO:00459361840.144
regulation of cd4 positive alpha beta t cell activationGO:2000514240.142
forebrain developmentGO:00309003020.140
regulation of protein ubiquitinationGO:0031396520.140
regulation of peptidyl tyrosine phosphorylationGO:0050730930.139
purine containing compound catabolic processGO:00725232130.138
organic cyclic compound catabolic processGO:19013612950.137
positive regulation of t helper 1 cell differentiationGO:004562740.136
regulation of toll like receptor signaling pathwayGO:0034121200.133
cytoplasmic transportGO:00164822340.133
regulation of antibacterial peptide biosynthetic processGO:000280810.133
autophagyGO:0006914450.132
ribonucleoside triphosphate metabolic processGO:00091992200.130
organonitrogen compound biosynthetic processGO:19015661920.129
regulation of lipid metabolic processGO:00192161180.128
response to organonitrogen compoundGO:00102432460.126
purine ribonucleotide catabolic processGO:00091542080.126
regulation of interleukin 1 beta productionGO:0032651250.126
alpha beta t cell activationGO:0046631910.125
negative regulation of response to woundingGO:1903035770.125
germ cell developmentGO:00072811850.124
purine ribonucleoside metabolic processGO:00461282410.121
chemotaxisGO:00069352470.120
negative regulation of nervous system developmentGO:00519611560.120
histone modificationGO:00165701590.120
Mouse
negative regulation of cell cycleGO:00457861230.119
Human
negative regulation of cellular amino acid metabolic processGO:004576300.119
cytoplasmic pattern recognition receptor signaling pathwayGO:0002753100.119
blood vessel morphogenesisGO:00485142850.118
regulation of interleukin 1 productionGO:0032652260.118
tumor necrosis factor superfamily cytokine productionGO:0071706510.118
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.115
cd4 positive alpha beta t cell activationGO:0035710450.114
Mouse
regulation of acute inflammatory responseGO:0002673270.114
nik nf kappab signalingGO:0038061140.114
cellular response to hormone stimulusGO:00328701500.113
ribonucleoside metabolic processGO:00091192450.113
nucleotide binding oligomerization domain containing signaling pathwayGO:007042360.113
positive regulation of interleukin 12 productionGO:0032735210.112
negative regulation of myeloid cell differentiationGO:0045638380.111
ribonucleoside catabolic processGO:00424542060.111
negative regulation of t cell proliferationGO:0042130380.111
regulation of protein kinase activityGO:00458592320.110
regulation of reactive oxygen species metabolic processGO:2000377400.109
response to amino acidGO:0043200370.109
purine nucleoside catabolic processGO:00061522050.108
protein catabolic processGO:00301632210.107
positive regulation of reactive oxygen species metabolic processGO:2000379110.105
dna recombinationGO:0006310920.105
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.105
b cell mediated immunityGO:0019724710.105
Mouse
cd4 positive or cd8 positive alpha beta t cell lineage commitmentGO:004336980.104
Mouse
regulation of cytoplasmic transportGO:19036491120.104
immunoglobulin production involved in immunoglobulin mediated immune responseGO:0002381430.101
regulation of interleukin 1 beta secretionGO:0050706150.101
response to oxygen levelsGO:0070482620.100
t cell differentiation involved in immune responseGO:0002292300.099
Mouse
positive regulation of antimicrobial peptide biosynthetic processGO:000280710.099
regulation of type 2 immune responseGO:0002828180.099
regulation of inflammatory responseGO:00507271470.098
regulation of protein localizationGO:00328802310.098
intracellular receptor signaling pathwayGO:0030522740.096
toll like receptor signaling pathwayGO:0002224380.096
regulation of kinase activityGO:00435492490.094
regulation of interleukin 1 secretionGO:0050704150.094
regulation of protein transportGO:00512231630.093
positive regulation of apoptotic signaling pathwayGO:2001235950.092
isotype switchingGO:0045190360.092
body morphogenesisGO:0010171450.091
regulation of secretionGO:00510462740.091
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.091
myeloid dendritic cell differentiationGO:0043011160.091
Mouse
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.091
ribonucleotide metabolic processGO:00092592910.091
negative regulation of transferase activityGO:0051348850.090
positive regulation of cytokine biosynthetic processGO:0042108400.089
angiogenesisGO:00015252010.088
morphogenesis of a branching structureGO:00017632030.087
interleukin 1 beta secretionGO:0050702160.087
regulation of hydrolase activityGO:00513362460.087
regulation of transferase activityGO:00513382630.087
ossificationGO:00015032160.086
gonad developmentGO:00084061410.086
extrinsic apoptotic signaling pathwayGO:00971911260.086
regulation of proteolysisGO:00301621640.086
negative regulation of intracellular signal transductionGO:19025321670.085
regulation of stem cell proliferationGO:0072091780.084
protein localization to organelleGO:00333651850.083
response to light stimulusGO:00094161350.083
regulation of interleukin 6 productionGO:0032675550.082
tyrosine phosphorylation of stat1 proteinGO:004250830.082
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.081
leukocyte migrationGO:00509001240.080
regulation of antimicrobial peptide productionGO:000278410.079
t cell differentiation in thymusGO:0033077770.078
regulation of multi organism processGO:00439001110.078
Mouse
response to peptideGO:19016521360.078
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.078
modification dependent protein catabolic processGO:00199411330.077
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.077
negative regulation of lymphocyte mediated immunityGO:0002707210.076
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.076
regulation of reactive oxygen species biosynthetic processGO:190342620.075
stem cell proliferationGO:00720891170.075
stem cell differentiationGO:00488632680.075
leukocyte apoptotic processGO:0071887710.074
epithelial tube morphogenesisGO:00605623030.074
regulation of intracellular transportGO:00323861590.074
positive regulation of cellular component biogenesisGO:0044089940.073
Mouse
positive regulation of leukocyte mediated immunityGO:0002705700.072
regulation of antimicrobial peptide biosynthetic processGO:000280510.072
negative regulation of leukocyte differentiationGO:1902106510.071
regulation of antibacterial peptide productionGO:000278610.071
rna interferenceGO:001624620.071
female sex differentiationGO:0046660840.071
regulation of t cell differentiationGO:0045580830.071
positive regulation of tolerance induction dependent upon immune responseGO:000265410.071
positive regulation of protein phosphorylationGO:00019342420.071
positive regulation of rho gtpase activityGO:0032321410.071
regulation of leukocyte proliferationGO:00706631210.070
regulation of establishment of protein localizationGO:00702011810.070
type i interferon productionGO:0032606290.069
syncytium formation by plasma membrane fusionGO:0000768420.069
acute inflammatory responseGO:0002526410.069
modulation by virus of host morphology or physiologyGO:001904830.068
regulation of t helper 1 cell differentiationGO:004562570.068
purine nucleoside metabolic processGO:00422782410.068
negative regulation of cellular component organizationGO:00511291940.067
regulation of tumor necrosis factor productionGO:0032680490.067
regulation of ras protein signal transductionGO:00465781140.067
neural tube developmentGO:00219151600.067
cellular protein catabolic processGO:00442571550.066
regulation of b cell mediated immunityGO:0002712370.066
regulation of notch signaling pathwayGO:0008593350.066
development of primary sexual characteristicsGO:00451371430.066
cd4 positive alpha beta t cell differentiationGO:0043367410.066
Mouse
ubiquitin dependent protein catabolic processGO:00065111290.066
regulation of cell cycleGO:00517262810.065
Human
response to nicotineGO:003509460.065
tumor necrosis factor productionGO:0032640500.065
regulation of cytoskeleton organizationGO:00514931220.065
regulation of striated muscle cell differentiationGO:0051153810.065
response to hypoxiaGO:0001666580.065
negative regulation of toll like receptor signaling pathwayGO:0034122140.064
Mouse
negative regulation of inflammatory response to antigenic stimulusGO:0002862100.063
regulation of apoptotic signaling pathwayGO:20012331970.063
purine containing compound metabolic processGO:00725213110.063
positive regulation of leukocyte differentiationGO:1902107860.062
t helper 2 cell differentiationGO:0045064120.062
positive regulation of t cell activationGO:00508701010.062
alpha beta t cell differentiationGO:0046632690.062
stem cell maintenanceGO:00198271300.062
interleukin 12 biosynthetic processGO:004209080.061
positive regulation of response to cytokine stimulusGO:0060760110.061
Mouse
negative regulation of viral processGO:0048525230.060
necrotic cell deathGO:0070265300.060
Mouse
mitotic cell cycleGO:00002781950.059
developmental maturationGO:00217001930.059
regionalizationGO:00030023370.058
regulation of membrane potentialGO:00423911920.058
regulation of protein modification by small protein conjugation or removalGO:1903320570.058
regulation of alpha beta t cell activationGO:0046634530.058
nucleocytoplasmic transportGO:00069131390.058
type i interferon biosynthetic processGO:004535190.058
Mouse
dendritic cell differentiationGO:0097028260.058
Mouse
nucleoside metabolic processGO:00091162460.057
purine ribonucleotide metabolic processGO:00091502900.057
positive regulation of cysteine type endopeptidase activityGO:2001056390.057
response to inorganic substanceGO:0010035960.057
positive regulation of antigen processing and presentationGO:0002579100.057
negative regulation of cell developmentGO:00107211690.057
keratinocyte differentiationGO:0030216480.056
Mouse
somatic diversification of immune receptorsGO:0002200530.056
cd8 positive alpha beta t cell proliferationGO:003574010.056
regulation of necroptotic processGO:0060544100.056
amide transportGO:00428861380.054
regulation of protein secretionGO:0050708820.054
response to decreased oxygen levelsGO:0036293590.054
regulation of tyrosine phosphorylation of stat1 proteinGO:004251020.054
cellular response to peptideGO:1901653920.054
cell type specific apoptotic processGO:00972852680.054
positive regulation of production of molecular mediator of immune responseGO:0002702450.054
regulation of lymphocyte apoptotic processGO:0070228410.053
adhesion of symbiont to hostGO:004440680.053
organic hydroxy compound metabolic processGO:19016152030.053
protein processingGO:00164851630.053
chromatin organizationGO:00063252060.053
Mouse
positive regulation of nervous system developmentGO:00519622210.053
intrinsic apoptotic signaling pathwayGO:00971931320.053
proteolysis involved in cellular protein catabolic processGO:00516031470.052
positive regulation of endopeptidase activityGO:0010950430.052
stem cell developmentGO:00488642190.051
nucleoside triphosphate catabolic processGO:00091432050.051
glial cell differentiationGO:00100011310.051
positive regulation of t cell differentiationGO:0045582520.051
regulation of myd88 dependent toll like receptor signaling pathwayGO:003412420.051
positive regulation of defense response to bacteriumGO:190042610.051
positive regulation of notch signaling pathwayGO:0045747180.051
t cell lineage commitmentGO:0002360130.051
Mouse
cell fate commitmentGO:00451652100.051
Mouse
negative regulation of nik nf kappab signalingGO:190122320.051
myeloid leukocyte migrationGO:0097529570.051
regulation of production of molecular mediator of immune responseGO:0002700650.050
intracellular protein transportGO:00068862040.050
positive regulation of antibacterial peptide biosynthetic processGO:000696310.050
regulation of intracellular protein transportGO:0033157820.049
ribonucleotide catabolic processGO:00092612080.049
response to muramyl dipeptideGO:003249590.049
positive regulation of t cell proliferationGO:0042102520.049
muscle tissue developmentGO:00605373080.049
interleukin 4 productionGO:0032633240.049
negative regulation of cell motilityGO:2000146610.049
granulocyte chemotaxisGO:0071621390.049
somatic cell dna recombinationGO:0016444510.049
regulation of immunoglobulin mediated immune responseGO:0002889370.048
purine nucleotide metabolic processGO:00061633020.048
rhythmic processGO:00485111740.048
positive regulation of antimicrobial humoral responseGO:000276020.048
citrate metabolic processGO:000610130.048
regulation of inflammatory response to antigenic stimulusGO:0002861210.047
chromatin modificationGO:00165681870.047
Mouse
response to copper ionGO:004668830.047
negative regulation of intracellular protein transportGO:0090317270.047
regulation of t helper 1 type immune responseGO:0002825170.047
interleukin 11 mediated signaling pathwayGO:003815420.046
cellular response to growth factor stimulusGO:00713631970.046
maintenance of locationGO:0051235890.046
response to oxidative stressGO:00069791230.046
negative regulation of t cell differentiationGO:0045581230.046
sequestering of metal ionGO:0051238190.046
interleukin 12 productionGO:0032615320.046
immunoglobulin productionGO:0002377730.046
positive t cell selectionGO:0043368230.046
Mouse
protein targetingGO:00066051430.045
regulation of natural killer cell differentiationGO:0032823110.045
regulation of mapk cascadeGO:00434082480.045
reactive nitrogen species metabolic processGO:200105700.045
regulation of cytokine production involved in immune responseGO:0002718260.045
cell chemotaxisGO:0060326810.045
regulation of organelle organizationGO:00330432890.045
polysaccharide metabolic processGO:0005976390.045
cellular response to external stimulusGO:0071496880.045
Human
generation of precursor metabolites and energyGO:00060911030.045
positive regulation of nucleotide metabolic processGO:00459811140.044
positive regulation of reactive oxygen species biosynthetic processGO:190342820.044
cellular response to steroid hormone stimulusGO:0071383330.044
negative regulation of leukocyte proliferationGO:0070664460.044
neuron apoptotic processGO:00514021420.044
regulation of cell activationGO:00508652890.044
cation transportGO:00068123990.044
dendrite developmentGO:00163581150.044
regulation of protein localization to nucleusGO:1900180600.044
regulation of mast cell differentiationGO:006037530.044
modification of morphology or physiology of other organism involved in symbiotic interactionGO:0051817160.043
release of sequestered calcium ion into cytosolGO:0051209420.043
positive regulation of type i interferon mediated signaling pathwayGO:006034040.043
Mouse
jak stat cascade involved in growth hormone signaling pathwayGO:006039740.043
mammary gland morphogenesisGO:0060443540.043
neuron deathGO:00709971540.042
negative regulation of lymphocyte proliferationGO:0050672450.042
regulation of defense response to fungusGO:190015010.042
establishment of protein localization to organelleGO:00725941180.042
cd4 positive alpha beta t cell lineage commitmentGO:004337360.042
Mouse
t cell selectionGO:0045058340.042
Mouse
cellular homeostasisGO:00197252400.041
positive regulation of interleukin 1 beta productionGO:0032731160.041
tolerance induction dependent upon immune responseGO:000246110.041
regulation of muscle tissue developmentGO:1901861970.041
response to interleukin 1GO:0070555110.041

Irf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.069
nervous system diseaseDOID:86300.069
central nervous system diseaseDOID:33100.051
primary immunodeficiency diseaseDOID:61200.049
severe combined immunodeficiencyDOID:62700.049
combined t cell and b cell immunodeficiencyDOID:62800.049
immune system diseaseDOID:291400.049