Mus musculus

90 known processes

Spon2

spondin 2, extracellular matrix protein

(Aliases: M-spondin,Mspondin,Mindin,2310045I24Rik,AI504350)

Spon2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
rho protein signal transductionGO:0007266320.102
innate immune responseGO:00450871570.101
cellular amine metabolic processGO:0044106440.093
immune effector processGO:00022523210.091
extrinsic apoptotic signaling pathwayGO:00971911260.083
ras protein signal transductionGO:0007265770.083
apoptotic signaling pathwayGO:00971903060.079
small gtpase mediated signal transductionGO:0007264970.074
extracellular structure organizationGO:00430621480.071
amine metabolic processGO:0009308450.064
regulation of cellular amine metabolic processGO:0033238200.063
regulation of anatomical structure sizeGO:00900661780.061
organic hydroxy compound metabolic processGO:19016152030.060
ear developmentGO:00435832000.059
purine containing compound metabolic processGO:00725213110.058
wound healingGO:00420601570.053
nucleobase containing small molecule metabolic processGO:00550863520.053
heterocycle catabolic processGO:00467002800.053
cytokine productionGO:00018163190.052
regulation of hydrolase activityGO:00513362460.052
regulation of inflammatory responseGO:00507271470.050
ribonucleotide metabolic processGO:00092592910.050
purine nucleoside triphosphate metabolic processGO:00091442260.050
purine nucleotide metabolic processGO:00061633020.049
positive regulation of cellular amino acid metabolic processGO:004576430.049
nucleoside triphosphate metabolic processGO:00091412300.048
regulation of body fluid levelsGO:00508781620.047
protein catabolic processGO:00301632210.046
nucleoside phosphate catabolic processGO:19012922220.045
cell type specific apoptotic processGO:00972852680.045
organonitrogen compound catabolic processGO:19015652640.045
positive regulation of cellular amine metabolic processGO:003324050.045
regulation of cell activationGO:00508652890.044
nucleoside phosphate metabolic processGO:00067533380.044
anion transportGO:00068201770.043
blood circulationGO:00080151950.043
cellular amino acid metabolic processGO:00065201030.042
regulation of cytokine productionGO:00018172660.042
ribose phosphate metabolic processGO:00196932910.042
cellular lipid metabolic processGO:00442553230.042
cellular response to cytokine stimulusGO:00713451890.041
ossificationGO:00015032160.041
regulation of response to woundingGO:19030341890.041
regulation of cellular catabolic processGO:00313292420.040
endocytosisGO:00068971680.040
cellular nitrogen compound catabolic processGO:00442702800.039
carbohydrate derivative catabolic processGO:19011362310.039
small molecule biosynthetic processGO:00442831320.039
cardiac muscle tissue developmentGO:00487381300.038
male gamete generationGO:00482322850.038
inflammatory responseGO:00069542440.038
immune response activating signal transductionGO:00027571160.038
organic cyclic compound catabolic processGO:19013612950.038
regulation of cellular amino acid metabolic processGO:000652150.037
purine ribonucleoside metabolic processGO:00461282410.037
lung developmentGO:00303241640.037
regulation of ras protein signal transductionGO:00465781140.036
extracellular matrix organizationGO:00301981470.036
regulation of defense responseGO:00313472330.036
macromolecule catabolic processGO:00090572810.036
collagen fibril organizationGO:0030199320.036
skin developmentGO:00435882200.035
transmembrane transportGO:00550854120.035
regulation of purine nucleotide catabolic processGO:00331211220.035
regulation of organelle organizationGO:00330432890.035
protein processingGO:00164851630.035
glycosyl compound metabolic processGO:19016572460.034
regulation of cellular ketone metabolic processGO:0010565660.034
cellular ketone metabolic processGO:0042180840.034
negative regulation of intracellular signal transductionGO:19025321670.034
positive regulation of cytokine productionGO:00018191740.034
purine ribonucleotide metabolic processGO:00091502900.034
protein maturationGO:00516041760.034
signal transduction in absence of ligandGO:0038034550.034
nucleotide metabolic processGO:00091173320.034
cellular ion homeostasisGO:00068731650.034
alcohol metabolic processGO:00060661160.033
purine ribonucleotide catabolic processGO:00091542080.033
activation of immune responseGO:00022531380.033
aromatic compound catabolic processGO:00194392860.032
regulation of secretionGO:00510462740.032
nucleoside triphosphate catabolic processGO:00091432050.032
leukocyte differentiationGO:00025213420.032
synaptic transmissionGO:00072683290.032
lipid biosynthetic processGO:00086101790.031
positive regulation of cell deathGO:00109422240.031
regulation of lymphocyte activationGO:00512492400.030
spermatogenesisGO:00072832840.030
cellular chemical homeostasisGO:00550822150.030
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.030
forebrain developmentGO:00309003020.029
purine ribonucleoside catabolic processGO:00461302050.029
regulation of protein transportGO:00512231630.029
ribonucleotide catabolic processGO:00092612080.029
ribonucleoside metabolic processGO:00091192450.029
negative regulation of cellular component organizationGO:00511291940.029
regulation of cell motilityGO:20001452360.028
regulation of protein secretionGO:0050708820.028
glycoprotein biosynthetic processGO:0009101890.028
mapk cascadeGO:00001652810.028
regulation of apoptotic signaling pathwayGO:20012331970.028
ribonucleoside triphosphate metabolic processGO:00091992200.028
cellular macromolecule catabolic processGO:00442652060.028
developmental maturationGO:00217001930.027
maintenance of locationGO:0051235890.027
purine containing compound catabolic processGO:00725232130.027
epithelial tube morphogenesisGO:00605623030.027
regulation of action potentialGO:009890040.027
purine nucleotide catabolic processGO:00061952110.027
symbiosis encompassing mutualism through parasitismGO:0044403830.027
regulation of gtp catabolic processGO:00331241130.027
purine ribonucleoside triphosphate catabolic processGO:00092071990.027
organophosphate catabolic processGO:00464342320.027
purine nucleoside triphosphate catabolic processGO:00091462030.027
single organism cell adhesionGO:00986021560.027
regulation of innate immune responseGO:0045088910.027
peptidyl amino acid modificationGO:00181933360.026
ion transmembrane transportGO:00342203610.026
regulation of cytoskeleton organizationGO:00514931220.026
negative regulation of molecular functionGO:00440922580.026
cell adhesionGO:00071553290.026
carbohydrate derivative biosynthetic processGO:19011371830.026
glycoprotein metabolic processGO:00091001160.025
positive regulation of defense responseGO:00313491240.025
phagocytosisGO:0006909660.025
skeletal system developmentGO:00015013560.025
proteolysis involved in cellular protein catabolic processGO:00516031470.025
regulation of nucleotide metabolic processGO:00061401690.025
organic hydroxy compound biosynthetic processGO:1901617770.025
regulation of system processGO:00440572000.025
positive regulation of cell activationGO:00508671580.025
skeletal system morphogenesisGO:00487052030.025
organonitrogen compound biosynthetic processGO:19015661920.024
regulation of establishment of protein localizationGO:00702011810.024
nucleoside metabolic processGO:00091162460.024
circulatory system processGO:00030131970.024
negative regulation of phospholipase activityGO:001051940.024
regulation of interleukin 8 productionGO:003267730.024
cellular protein complex assemblyGO:00436231160.024
regulation of purine nucleotide metabolic processGO:19005421690.024
sensory perceptionGO:00076002450.024
nucleoside catabolic processGO:00091642060.024
regulation of multi organism processGO:00439001110.024
positive regulation of purine nucleotide metabolic processGO:19005441140.024
glycosyl compound catabolic processGO:19016582060.024
striated muscle cell developmentGO:00550021250.024
negative regulation of phosphorylationGO:00423261660.023
sensory organ morphogenesisGO:00905962420.023
defense response to other organismGO:00985421970.023
pattern recognition receptor signaling pathwayGO:0002221470.023
actin cytoskeleton organizationGO:00300362200.023
muscle tissue developmentGO:00605373080.023
interspecies interaction between organismsGO:0044419830.023
response to organic cyclic compoundGO:00140701980.023
cellular homeostasisGO:00197252400.023
positive regulation of cellular catabolic processGO:00313311480.023
gtp metabolic processGO:00460391440.023
steroid metabolic processGO:00082021190.023
sequestering of calcium ionGO:0051208180.023
actin filament organizationGO:00070151130.022
regulation of striated muscle cell differentiationGO:0051153810.022
positive regulation of innate immune responseGO:0045089800.022
response to molecule of bacterial originGO:00022371430.022
negative regulation of protein metabolic processGO:00512482820.022
endomembrane system organizationGO:00102561470.022
leukocyte migrationGO:00509001240.022
ribonucleoside catabolic processGO:00424542060.022
activation of innate immune responseGO:0002218560.022
regulation of ion transportGO:00432692150.022
single organismal cell cell adhesionGO:00163371310.022
negative regulation of cellular amine metabolic processGO:003323910.021
defense response to virusGO:0051607680.021
membrane organizationGO:00610242450.021
cell maturationGO:00484691270.021
nucleotide catabolic processGO:00091662170.021
hematopoietic progenitor cell differentiationGO:00022441430.021
regulation of vesicle mediated transportGO:00606271390.021
positive regulation of immune effector processGO:00026991070.021
blood coagulationGO:0007596760.021
gland developmentGO:00487323300.020
response to organonitrogen compoundGO:00102432460.020
purine ribonucleoside triphosphate metabolic processGO:00092052200.020
intracellular receptor signaling pathwayGO:0030522740.020
engulfment of apoptotic cellGO:004365230.020
regulation of protein localizationGO:00328802310.020
intrinsic apoptotic signaling pathwayGO:00971931320.020
interleukin 6 productionGO:0032635580.020
regulation of transferase activityGO:00513382630.020
response to inorganic substanceGO:0010035960.020
muscle cell differentiationGO:00426922610.020
reactive oxygen species metabolic processGO:0072593840.020
innate immune response activating signal transductionGO:0002758500.020
toll like receptor signaling pathwayGO:0002224380.020
divalent inorganic cation homeostasisGO:00725071380.019
regulation of cellular response to stressGO:00801351590.019
organophosphate biosynthetic processGO:00904071220.019
regulation of membrane potentialGO:00423911920.019
regulation of secretion by cellGO:19035302490.019
protein secretionGO:00093061110.019
positive regulation of kinase activityGO:00336741550.019
immune response regulating signaling pathwayGO:00027641250.019
oxidation reduction processGO:00551143420.019
striated muscle tissue developmentGO:00147062930.019
purine nucleoside metabolic processGO:00422782410.019
regulation of reactive oxygen species biosynthetic processGO:190342620.019
leukocyte proliferationGO:00706611720.019
positive regulation of cell adhesionGO:0045785800.019
morphogenesis of a branching epitheliumGO:00611381930.019
divalent metal ion transportGO:00708381720.019
purine nucleoside catabolic processGO:00061522050.019
t cell activationGO:00421102890.018
tissue homeostasisGO:00018941150.018
positive regulation of lymphocyte activationGO:00512511400.018
neural precursor cell proliferationGO:00613511210.018
action potentialGO:0001508780.018
proteoglycan biosynthetic processGO:0030166200.018
defense response to bacteriumGO:00427421190.018
camera type eye developmentGO:00430102660.018
regulation of proteolysisGO:00301621640.018
regulation of nucleoside metabolic processGO:00091181300.018
positive regulation of interleukin 8 productionGO:003275720.018
proteoglycan metabolic processGO:0006029380.018
cellular response to external stimulusGO:0071496880.017
skeletal muscle organ developmentGO:00605381630.017
cellular response to organonitrogen compoundGO:00714171450.017
regulation of leukocyte proliferationGO:00706631210.017
regulation of nucleotide catabolic processGO:00308111220.017
establishment of blood nerve barrierGO:000806530.017
negative regulation of apoptotic signaling pathwayGO:20012341040.017
regulation of endocytosisGO:0030100690.017
sulfur compound metabolic processGO:00067901000.017
cellular calcium ion homeostasisGO:00068741190.017
positive regulation of protein modification processGO:00314012990.017
guanosine containing compound catabolic processGO:19010691440.017
interleukin 8 productionGO:003263740.017
regulation of lymphocyte proliferationGO:00506701170.017
regulation of phagocytosisGO:0050764330.016
positive regulation of hydrolase activityGO:00513451480.016
cation homeostasisGO:00550802120.016
calcium ion homeostasisGO:00550741270.016
regulation of rho protein signal transductionGO:0035023710.016
organelle assemblyGO:00709251770.016
negative regulation of cell activationGO:00508661110.016
regulation of feeding behaviorGO:006025930.016
regulation of mapk cascadeGO:00434082480.016
anatomical structure homeostasisGO:00602491450.016
ubiquitin dependent protein catabolic processGO:00065111290.016
neuron migrationGO:00017641220.016
regulation of hormone levelsGO:00108172110.016
mitochondrion organizationGO:00070051340.016
regulation of homeostatic processGO:00328441820.016
bone morphogenesisGO:0060349780.016
actin filament based movementGO:0030048230.016
protein polymerizationGO:0051258570.016
negative regulation of cellular protein metabolic processGO:00322692470.016
regionalizationGO:00030023370.015
guanosine containing compound metabolic processGO:19010681440.015
ribonucleoside triphosphate catabolic processGO:00092031990.015
short chain fatty acid catabolic processGO:001962620.015
fatty acid metabolic processGO:00066311210.015
posttranscriptional regulation of gene expressionGO:00106081550.015
regulation of rho gtpase activityGO:0032319580.015
regulation of actin filament based processGO:0032970990.015
gtp catabolic processGO:00061841430.015
regulation of blood circulationGO:1903522930.015
carboxylic acid biosynthetic processGO:0046394860.015
negative regulation of cell proliferationGO:00082852960.015
positive regulation of protein phosphorylationGO:00019342420.015
positive regulation of interleukin 6 productionGO:0032755370.015
cellular response to biotic stimulusGO:0071216920.015
positive regulation of transferase activityGO:00513471670.015
myeloid leukocyte differentiationGO:00025731190.015
dna metabolic processGO:00062593030.015
regulation of reactive oxygen species metabolic processGO:2000377400.015
regulation of kinase activityGO:00435492490.015
fat soluble vitamin biosynthetic processGO:004236240.015
cytokine secretionGO:0050663720.015
regulation of cell projection organizationGO:00313442060.015
midgut developmentGO:000749440.015
epidermis developmentGO:00085441870.015
renal system developmentGO:00720012250.015
chondrocyte differentiationGO:0002062720.015
positive regulation of apoptotic processGO:00430652170.015
protein modification by small protein conjugationGO:00324461870.015
myosin filament assemblyGO:003103420.014
urogenital system developmentGO:00016552610.014
telencephalon developmentGO:00215371860.014
cellular divalent inorganic cation homeostasisGO:00725031270.014
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiationGO:200072120.014
reactive nitrogen species metabolic processGO:200105700.014
microtubule based processGO:00070172360.014
negative regulation of growthGO:0045926990.014
nephric duct formationGO:007217940.014
production of molecular mediator of immune responseGO:00024401030.014
regulation of protein catabolic processGO:00421761080.014
cell killingGO:0001906670.014
positive regulation of protein serine threonine kinase activityGO:00719021060.014
negative regulation of t cell activationGO:0050868650.014
positive regulation of cytosolic calcium ion concentrationGO:0007204650.014
compound eye developmentGO:004874910.014
regulation of lipid metabolic processGO:00192161180.014
tissue remodelingGO:00487711020.014
regulation of actin cytoskeleton organizationGO:0032956840.014
positive regulation of protein transportGO:0051222930.014
hemostasisGO:0007599780.014
protein modification by small protein conjugation or removalGO:00706472070.014
nephron developmentGO:00720061090.013
appendage developmentGO:00487361660.013
cellular metal ion homeostasisGO:00068751510.013
lipid localizationGO:00108761260.013
physiological cardiac muscle hypertrophyGO:000330130.013
organic acid biosynthetic processGO:0016053860.013
regulation of neural precursor cell proliferationGO:2000177700.013
homeostasis of number of cellsGO:00488722100.013
ear morphogenesisGO:00424711180.013
cell substrate adhesionGO:00315891300.013
mesonephros developmentGO:0001823970.013
cellular protein catabolic processGO:00442571550.013
epithelial cell developmentGO:00020641590.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.013
positive regulation of leukocyte proliferationGO:0070665730.013
regulation of protein maturationGO:1903317960.013
positive regulation of mapk cascadeGO:00434101700.013
stem cell developmentGO:00488642190.013
hormone metabolic processGO:0042445860.013
regulation of protein kinase activityGO:00458592320.013
positive regulation of tumor necrosis factor superfamily cytokine productionGO:1903557310.013
cellular response to inorganic substanceGO:0071241370.013
actin filament bundle assemblyGO:0051017400.013
cellular response to peptidoglycanGO:007122440.013
protein ubiquitinationGO:00165671710.013
negative regulation of protein processingGO:0010955790.013
negative regulation of phosphorus metabolic processGO:00105631840.013
striated muscle myosin thick filament assemblyGO:007168810.013
mitotic cell cycleGO:00002781950.013
chemokine productionGO:0032602340.013
female meiosis chromosome segregationGO:001632110.013
positive regulation of proteolysisGO:0045862850.013
actin polymerization or depolymerizationGO:0008154540.013
organelle localizationGO:00516401790.012
negative regulation of cellular amino acid metabolic processGO:004576300.012
divalent inorganic cation transportGO:00725111780.012
regulation of interferon gamma productionGO:0032649570.012
nitrogen compound transportGO:00717052710.012
negative regulation of cell migrationGO:0030336590.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.012
cell growthGO:00160491300.012
regulation of angiogenesisGO:0045765810.012
cytokine biosynthetic processGO:0042089680.012
lymphocyte differentiationGO:00300982420.012
myosin filament organizationGO:003103330.012
regulation of renin secretion into blood streamGO:190013340.012
actomyosin structure organizationGO:0031032560.012
regulation of muscle tissue developmentGO:1901861970.012
cell junction organizationGO:0034330770.012
negative regulation of proteolysisGO:0045861740.012
positive regulation of muscle cell differentiationGO:0051149390.012
regulation of blood coagulationGO:0030193280.012
atp metabolic processGO:0046034750.012
negative regulation of nervous system developmentGO:00519611560.012
lymphocyte proliferationGO:00466511640.012
regulation of cell migrationGO:00303342190.012
branching morphogenesis of an epithelial tubeGO:00487541590.012
regulation of cysteine type endopeptidase activityGO:2000116650.012
sulfur compound biosynthetic processGO:0044272370.012
cellular component assembly involved in morphogenesisGO:00109271390.012
microtubule cytoskeleton organizationGO:00002261570.012
modification dependent macromolecule catabolic processGO:00436321330.012
cellular response to extracellular stimulusGO:0031668810.012
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.012
chromatin modificationGO:00165681870.012
smoothened signaling pathwayGO:00072241050.012
cell growth involved in cardiac muscle cell developmentGO:006104930.012
multicellular organismal homeostasisGO:00488711640.012
plasma membrane organizationGO:0007009900.012
g protein coupled receptor signaling pathwayGO:00071862430.012
regulation of systemic arterial blood pressureGO:0003073610.012
blood vessel morphogenesisGO:00485142850.012
cellular response to growth factor stimulusGO:00713631970.012
cell matrix adhesionGO:0007160680.012
neuronal action potentialGO:0019228540.012
regulation of protein processingGO:0070613960.012
positive regulation of gtp catabolic processGO:0033126850.011
sequestering of metal ionGO:0051238190.011
cytokine metabolic processGO:0042107710.011
positive regulation of cellular component biogenesisGO:0044089940.011
oocyte axis specificationGO:000730920.011
positive regulation of phospholipase activityGO:001051830.011
positive regulation of vasoconstrictionGO:004590740.011
positive regulation of lymphocyte proliferationGO:0050671700.011
negative regulation of cytokine productionGO:0001818840.011
negative regulation of response to woundingGO:1903035770.011
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.011
muscle cell developmentGO:00550011330.011
generation of precursor metabolites and energyGO:00060911030.011
regulation of intracellular transportGO:00323861590.011
regulation of endopeptidase activityGO:0052548890.011
phenol containing compound metabolic processGO:0018958600.011
leukocyte mediated immunityGO:00024431740.011
modification of morphology or physiology of other organismGO:0035821180.011
negative regulation of hydrolase activityGO:0051346710.011
regulation of t cell proliferationGO:0042129920.011
regulation of bone remodelingGO:0046850280.011
positive regulation of secretion by cellGO:19035321140.011
regulation of wound healingGO:0061041400.011
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.011
cell recognitionGO:0008037830.011
positive regulation of nucleotide metabolic processGO:00459811140.011
carbohydrate metabolic processGO:00059752300.011
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.011
cardiocyte differentiationGO:0035051870.011
response to growth factorGO:00708481980.011
actin mediated cell contractionGO:0070252150.011
organ growthGO:00352651170.011
cellular amide metabolic processGO:0043603580.011
cognitionGO:00508901490.011
heart contractionGO:0060047930.011
rac protein signal transductionGO:0016601130.011
tumor necrosis factor superfamily cytokine productionGO:0071706510.011
regulation of cytokine secretionGO:0050707610.011
regulation of peptidase activityGO:0052547960.011
embryonic placenta developmentGO:0001892980.011
interferon gamma productionGO:0032609670.011
phagosome maturationGO:009038240.011
regulation of toll like receptor signaling pathwayGO:0034121200.011
regulation of cell cycleGO:00517262810.011
positive regulation of map kinase activityGO:0043406840.011
reactive oxygen species biosynthetic processGO:190340980.011
regulation of cellular component biogenesisGO:00440871810.011
glycosaminoglycan metabolic processGO:0030203340.011
regulation of vasculature developmentGO:1901342880.011
stem cell differentiationGO:00488632680.011
regulation of neuron differentiationGO:00456642810.011
heart morphogenesisGO:00030071780.011
epithelial cell proliferationGO:00506731740.011
inorganic cation transmembrane transportGO:00986622070.011
positive regulation of phagocytosisGO:0050766260.011
lipid transportGO:0006869980.011
regulation of protein complex assemblyGO:0043254830.011
glucose homeostasisGO:00425931280.011
coagulationGO:0050817780.011
negative regulation of phosphate metabolic processGO:00459361840.011
regulation of neuron apoptotic processGO:00435231220.011
modification dependent protein catabolic processGO:00199411330.010
renal tubule morphogenesisGO:0061333720.010
regulation of ion homeostasisGO:2000021640.010
exocytosisGO:00068871210.010
regulation of systemic arterial blood pressure mediated by a chemical signalGO:0003044330.010
lymphocyte activation involved in immune responseGO:0002285930.010
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.010
carbohydrate homeostasisGO:00335001280.010
morphogenesis of a branching structureGO:00017632030.010
adaptive immune responseGO:00022501550.010
response to lipopolysaccharideGO:00324961280.010
sensory perception of mechanical stimulusGO:00509541070.010
positive regulation of cytoskeleton organizationGO:0051495490.010
regulation of coagulationGO:0050818310.010
positive regulation of homeostatic processGO:0032846640.010
regulation of cell adhesionGO:00301551540.010
bone developmentGO:00603481200.010
lymphocyte mediated immunityGO:00024491390.010
female gamete generationGO:0007292740.010
locomotory behaviorGO:00076261950.010
cellular response to hormone stimulusGO:00328701500.010
myeloid cell differentiationGO:00300992330.010
protein localization to membraneGO:00726571080.010
transition metal ion transportGO:0000041380.010

Spon2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.049
disease of anatomical entityDOID:700.049
vascular diseaseDOID:17800.022
cardiovascular system diseaseDOID:128700.022
connective tissue diseaseDOID:6500.018
disease of metabolismDOID:001466700.014
nervous system diseaseDOID:86300.012
inherited metabolic disorderDOID:65500.011