Mus musculus

73 known processes

Itk

IL2-inducible T-cell kinase

(Aliases: Emt,Tcsk,Tsk)

Itk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
immune response activating cell surface receptor signaling pathwayGO:0002429720.997
immune response activating signal transductionGO:00027571160.992
antigen receptor mediated signaling pathwayGO:0050851640.973
t cell receptor signaling pathwayGO:0050852460.961
leukocyte mediated immunityGO:00024431740.934
positive regulation of t cell activationGO:00508701010.917
regulation of lymphocyte anergyGO:000291140.914
cytokine secretionGO:0050663720.841
stimulatory c type lectin receptor signaling pathwayGO:000222320.841
positive regulation of t cell costimulationGO:200052520.817
regulation of alpha beta t cell activationGO:0046634530.816
leukocyte differentiationGO:00025213420.814
immune response regulating cell surface receptor signaling pathwayGO:0002768800.796
regulation of t cell activationGO:00508631700.791
hematopoietic stem cell migrationGO:003570110.758
t cell differentiationGO:00302171740.740
adaptive immune responseGO:00022501550.735
positive regulation of alpha beta t cell activationGO:0046635390.701
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.690
cytokine productionGO:00018163190.670
leukocyte mediated cytotoxicityGO:0001909620.669
positive regulation of cd8 positive alpha beta t cell extravasationGO:200045120.664
regulation of interferon gamma productionGO:0032649570.662
innate immune responseGO:00450871570.658
regulation of cell activationGO:00508652890.657
Mouse
activation of immune responseGO:00022531380.645
t cell differentiation in thymusGO:0033077770.642
natural killer cell inhibitory signaling pathwayGO:000276920.626
regulation of interleukin 2 productionGO:0032663280.620
positive regulation of t cell receptor signaling pathwayGO:005086240.611
positive regulation of lymphocyte activationGO:00512511400.609
cell killingGO:0001906670.596
leukocyte activation involved in immune responseGO:00023661260.584
Mouse
immune effector processGO:00022523210.558
Mouse
lymphocyte mediated immunityGO:00024491390.554
regulation of lymphocyte activationGO:00512492400.550
interleukin 2 productionGO:0032623330.531
t cell activationGO:00421102890.528
thymic t cell selectionGO:0045061220.525
t cell proliferationGO:00420981200.509
cellular amine metabolic processGO:0044106440.498
positive regulation of cellular amine metabolic processGO:003324050.480
regulation of adaptive immune responseGO:0002819900.480
cell activation involved in immune responseGO:00022631260.478
Mouse
cytokine mediated signaling pathwayGO:00192211150.476
Mouse
negative t cell selectionGO:0043383130.454
alpha beta t cell activationGO:0046631910.452
lymphocyte differentiationGO:00300982420.441
positive regulation of lymphocyte mediated immunityGO:0002708620.415
regulation of protein localizationGO:00328802310.410
positive regulation of immunological synapse formationGO:200052210.407
somatic recombination of immunoglobulin gene segmentsGO:0016447420.400
negative thymic t cell selectionGO:0045060120.396
positive regulation of protein transportGO:0051222930.395
regulation of mast cell activationGO:0033003210.385
Mouse
positive regulation of hematopoietic stem cell migrationGO:200047310.381
immune response regulating signaling pathwayGO:00027641250.375
regulation of protein transportGO:00512231630.369
positive regulation of cytokine productionGO:00018191740.368
positive regulation of secretionGO:00510471300.360
helper t cell chemotaxisGO:003570410.354
regulation of t cell anergyGO:000266740.354
negative regulation of eosinophil degranulationGO:004331010.351
eosinophil degranulationGO:004330810.350
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.350
regulation of secretion by cellGO:19035302490.345
myeloid leukocyte migrationGO:0097529570.335
regulation of regulated secretory pathwayGO:1903305200.328
regulation of alpha beta t cell proliferationGO:0046640180.326
small gtpase mediated signal transductionGO:0007264970.321
regulation of eosinophil degranulationGO:004330910.320
regulation of secretionGO:00510462740.319
interferon gamma productionGO:0032609670.317
regulation of hematopoietic stem cell migrationGO:200047110.315
positive regulation of alpha beta t cell proliferationGO:0046641120.314
regulation of intracellular transportGO:00323861590.311
regulation of cytokine productionGO:00018172660.306
regulation of natural killer cell mediated immunityGO:0002715190.304
positive t cell selectionGO:0043368230.303
regulation of monocyte extravasationGO:200043720.300
microglial cell activationGO:000177430.300
regulation of lymphocyte mediated immunityGO:0002706840.299
regulation of leukocyte mediated cytotoxicityGO:0001910380.296
regulation of hydrolase activityGO:00513362460.285
interleukin 2 mediated signaling pathwayGO:003811020.283
peptidyl tyrosine modificationGO:00182121450.283
Human
regulation of innate immune responseGO:0045088910.282
cellular response to interleukin 15GO:007135020.282
membrane organizationGO:00610242450.282
lymphocyte anergyGO:000224940.280
positive regulation of t cell proliferationGO:0042102520.273
positive regulation of cell killingGO:0031343330.272
positive regulation of cellular amino acid metabolic processGO:004576430.269
regulation of cell killingGO:0031341400.269
defense response to bacteriumGO:00427421190.266
regulation of cellular ketone metabolic processGO:0010565660.266
divalent inorganic cation homeostasisGO:00725071380.262
regulation of cytokine secretionGO:0050707610.259
cellular ketone metabolic processGO:0042180840.258
regulation of response to woundingGO:19030341890.256
positive regulation of interferon gamma productionGO:0032729390.250
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formationGO:200052610.250
leukocyte chemotaxisGO:0030595690.242
myeloid leukocyte differentiationGO:00025731190.238
positive regulation of immune effector processGO:00026991070.236
Mouse
regulation of cellular amine metabolic processGO:0033238200.234
cd8 positive alpha beta t cell extravasationGO:003569730.234
cation homeostasisGO:00550802120.234
positive regulation of antigen receptor mediated signaling pathwayGO:005085790.233
regulation of leukocyte mediated immunityGO:00027031040.231
interleukin 4 productionGO:0032633240.230
regulation of inflammatory response to antigenic stimulusGO:0002861210.226
positive regulation of cell activationGO:00508671580.223
g protein coupled receptor signaling pathwayGO:00071862430.223
eosinophil activationGO:004330710.221
granzyme mediated apoptotic signaling pathwayGO:000862610.218
eosinophil activation involved in immune responseGO:000227810.217
regulation of natural killer cell mediated cytotoxicityGO:0042269190.217
positive regulation of cytokine secretionGO:0050715410.217
ras protein signal transductionGO:0007265770.216
t cell extravasationGO:007268340.215
positive regulation of t cell extravasationGO:200040920.214
immune complex clearanceGO:000243420.213
granulocyte activationGO:0036230100.212
second messenger mediated signalingGO:0019932730.209
apoptotic signaling pathwayGO:00971903060.200
regulation of antigen receptor mediated signaling pathwayGO:0050854290.199
positive regulation of lymphocyte proliferationGO:0050671700.198
negative regulation of protein metabolic processGO:00512482820.196
myeloid cell activation involved in immune responseGO:0002275340.194
Mouse
regulation of t cell extravasationGO:200040730.194
cellular response to molecule of fungal originGO:007122620.192
positive regulation of adaptive immune responseGO:0002821610.191
mast cell activation involved in immune responseGO:0002279200.190
Mouse
microglial cell activation involved in immune responseGO:000228210.188
granulocyte migrationGO:0097530430.188
eosinophil mediated immunityGO:000244710.187
granulocyte chemotaxisGO:0071621390.183
alpha beta t cell proliferationGO:0046633210.182
innate immune response activating cell surface receptor signaling pathwayGO:000222040.181
myeloid leukocyte activationGO:0002274830.181
Mouse
cellular extravasationGO:0045123170.179
Mouse
somatic diversification of immune receptorsGO:0002200530.175
regulation of cytokine biosynthetic processGO:0042035590.175
cell surface pattern recognition receptor signaling pathwayGO:000275220.175
regulation of interleukin 10 secretionGO:200117940.174
peptidyl amino acid modificationGO:00181933360.172
Human
negative regulation of growthGO:0045926990.171
defense response to other organismGO:00985421970.171
regulation of establishment of protein localizationGO:00702011810.170
cellular response to cytokine stimulusGO:00713451890.167
Mouse
regulation of cd8 positive alpha beta t cell extravasationGO:200044930.167
interleukin 12 secretionGO:007261030.167
chemokine mediated signaling pathwayGO:0070098170.166
carbohydrate metabolic processGO:00059752300.165
negative regulation of homeostatic processGO:0032845710.164
inflammatory response to antigenic stimulusGO:0002437300.161
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.161
regulation of dendritic cell chemotaxisGO:200050810.159
dendritic cell differentiationGO:0097028260.159
positive regulation of defense responseGO:00313491240.159
chemotaxisGO:00069352470.158
Mouse
natural killer cell mediated cytotoxicityGO:0042267290.157
amine metabolic processGO:0009308450.156
regulation of peptidyl tyrosine phosphorylationGO:0050730930.156
regulated secretory pathwayGO:0045055320.155
regulation of t cell costimulationGO:200052320.155
gamma delta t cell differentiationGO:0042492110.153
response to molecule of bacterial originGO:00022371430.153
Mouse
t cell costimulationGO:0031295140.152
mast cell activationGO:0045576270.150
Mouse
interleukin 10 secretionGO:007260840.150
positive regulation of natural killer cell mediated immunityGO:0002717160.149
regulation of cellular amino acid metabolic processGO:000652150.148
positive regulation of immune complex clearance by monocytes and macrophagesGO:009026520.147
regulation of monocyte chemotaxisGO:009002530.146
mature dendritic cell differentiationGO:009702930.145
positive regulation of lymphocyte anergyGO:000291340.145
monocyte extravasationGO:003569620.144
cellular amino acid metabolic processGO:00065201030.144
antigen processing and presentationGO:0019882470.139
positive regulation of monocyte extravasationGO:200043910.139
positive regulation of leukocyte mediated immunityGO:0002705700.138
b cell activation involved in immune responseGO:0002312500.136
negative regulation of cellular amine metabolic processGO:003323910.136
t cell mediated cytotoxicityGO:0001913260.134
regulation of t cell mediated cytotoxicityGO:0001914180.133
leukocyte migrationGO:00509001240.132
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.130
natural killer cell mediated immunityGO:0002228290.129
endocytosisGO:00068971680.129
t helper 1 type immune responseGO:0042088250.129
peptidyl tyrosine phosphorylationGO:00181081430.129
Human
metal ion homeostasisGO:00550651890.128
sequestering of calcium ionGO:0051208180.128
negative regulation of macrophage apoptotic processGO:200011030.127
dna recombinationGO:0006310920.127
regulation of cell migrationGO:00303342190.127
Mouse
reactive oxygen species metabolic processGO:0072593840.127
positive regulation of monocyte chemotaxisGO:009002620.125
protein secretionGO:00093061110.123
regulation of calcium mediated signalingGO:0050848190.122
regulation of t cell receptor signaling pathwayGO:0050856210.122
maintenance of locationGO:0051235890.120
cellular metal ion homeostasisGO:00068751510.118
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.118
Mouse
protein localization to organelleGO:00333651850.117
regulation of peptide transportGO:0090087910.116
calcium mediated signalingGO:0019722460.116
regulation of inflammatory responseGO:00507271470.116
regulation of type 2 immune responseGO:0002828180.116
positive regulation of interleukin 2 biosynthetic processGO:004508680.115
somatic recombination of immunoglobulin genes involved in immune responseGO:0002204360.114
positive regulation of inflammatory responseGO:0050729470.114
positive regulation of secretion by cellGO:19035321140.113
positive regulation of t cell anergyGO:000266940.112
cytoplasmic transportGO:00164822340.112
regulation of acute inflammatory responseGO:0002673270.112
immune complex clearance by monocytes and macrophagesGO:000243620.112
cellular lipid metabolic processGO:00442553230.110
negative regulation of protein phosphorylationGO:00019331260.110
b cell mediated immunityGO:0019724710.109
single organismal cell cell adhesionGO:00163371310.108
Mouse
natural killer cell activationGO:0030101440.108
myeloid cell differentiationGO:00300992330.107
positive regulation of calcium mediated signalingGO:0050850150.105
myeloid leukocyte mediated immunityGO:0002444420.103
positive thymic t cell selectionGO:0045059130.103
t helper 17 cell chemotaxisGO:003570510.101
t cell mediated immunityGO:0002456500.101
cytokine biosynthetic processGO:0042089680.100
macrophage activationGO:0042116270.099
positive regulation of inflammatory response to antigenic stimulusGO:0002863110.099
negative regulation of peptidyl tyrosine phosphorylationGO:0050732170.098
immunoglobulin mediated immune responseGO:0016064690.098
production of molecular mediator of immune responseGO:00024401030.097
dna metabolic processGO:00062593030.096
response to molecule of fungal originGO:000223840.095
nitrogen compound transportGO:00717052710.094
cellular homeostasisGO:00197252400.093
regulation of kinase activityGO:00435492490.092
interleukin 8 secretionGO:007260630.092
multicellular organismal signalingGO:0035637910.091
integrin mediated signaling pathwayGO:0007229270.091
regulation of immune complex clearance by monocytes and macrophagesGO:009026420.091
positive regulation of mapk cascadeGO:00434101700.091
leukocyte proliferationGO:00706611720.090
regulation of transferase activityGO:00513382630.089
regulation of lymphocyte differentiationGO:00456191070.089
rho protein signal transductionGO:0007266320.089
ameboidal type cell migrationGO:00016671280.088
Mouse
regulation of homeostatic processGO:00328441820.087
isotype switching to igg isotypesGO:0048291100.087
leukocyte degranulationGO:0043299270.087
regulation of protein secretionGO:0050708820.086
response to lipopolysaccharideGO:00324961280.085
Mouse
positive regulation of b cell mediated immunityGO:0002714260.085
alpha beta t cell differentiationGO:0046632690.085
negative regulation of cellular protein metabolic processGO:00322692470.085
forebrain developmentGO:00309003020.085
nuclear transportGO:00511691390.084
phagocytosisGO:0006909660.084
tolerance inductionGO:0002507140.084
somatic diversification of immunoglobulins involved in immune responseGO:0002208360.083
positive regulation of innate immune responseGO:0045089800.082
cell chemotaxisGO:0060326810.081
i kappab kinase nf kappab signalingGO:0007249850.081
b cell receptor signaling pathwayGO:0050853200.080
nucleotide metabolic processGO:00091173320.080
regulation of alpha beta t cell differentiationGO:0046637350.080
cell type specific apoptotic processGO:00972852680.080
regulation of toll like receptor 2 signaling pathwayGO:003413530.079
regulation of vesicle mediated transportGO:00606271390.078
extrinsic apoptotic signaling pathwayGO:00971911260.078
positive regulation of protein phosphorylationGO:00019342420.077
regulation of homotypic cell cell adhesionGO:0034110130.077
protein maturationGO:00516041760.076
leukocyte apoptotic processGO:0071887710.075
endomembrane system organizationGO:00102561470.074
response to interferon gammaGO:0034341340.074
positive regulation of cytokine biosynthetic processGO:0042108400.074
regulation of defense responseGO:00313472330.074
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.072
nucleocytoplasmic transportGO:00069131390.072
regulation of cytoplasmic transportGO:19036491120.072
calcium ion homeostasisGO:00550741270.072
regulation of t cell proliferationGO:0042129920.071
osteoclast differentiationGO:0030316620.070
immunoglobulin productionGO:0002377730.070
cell adhesionGO:00071553290.070
Mouse
neutrophil migrationGO:1990266370.069
protein processingGO:00164851630.068
exocytosisGO:00068871210.067
inflammatory responseGO:00069542440.066
cation transportGO:00068123990.066
plasma membrane organizationGO:0007009900.066
gamma delta t cell lineage commitmentGO:000236510.065
protein localization to nucleusGO:00345041210.065
regulation of chemotaxisGO:0050920530.063
negative regulation of phosphorylationGO:00423261660.063
t cell selectionGO:0045058340.062
cellular defense responseGO:000696860.062
regulation of leukocyte differentiationGO:19021051590.062
circulatory system processGO:00030131970.062
regulation of map kinase activityGO:00434051200.062
lymphocyte costimulationGO:0031294150.061
cytosolic calcium ion homeostasisGO:0051480700.061
detection of bacterial lipoproteinGO:004249410.059
symbiosis encompassing mutualism through parasitismGO:0044403830.059
bone resorptionGO:0045453380.059
regulation of leukocyte degranulationGO:0043300200.059
regulation of interleukin 8 secretionGO:200048220.059
pattern recognition receptor signaling pathwayGO:0002221470.058
growth of symbiont in hostGO:0044117230.058
peptide transportGO:00158331330.058
positive regulation of dendritic cell chemotaxisGO:200051010.057
telencephalon cell migrationGO:0022029550.057
t cell anergyGO:000287040.056
fc receptor mediated stimulatory signaling pathwayGO:000243140.056
t cell differentiation involved in immune responseGO:0002292300.056
cellular chemical homeostasisGO:00550822150.056
macromolecule catabolic processGO:00090572810.056
regulation of interleukin 8 productionGO:003267730.056
neutrophil chemotaxisGO:0030593360.056
endocrine processGO:0050886390.055
regulation of multi organism processGO:00439001110.055
positive regulation of t cell mediated cytotoxicityGO:0001916150.055
positive regulation of lipid metabolic processGO:0045834400.055
positive regulation of interleukin 2 productionGO:0032743190.054
isotype switchingGO:0045190360.054
positive regulation of natural killer cell mediated cytotoxicityGO:0045954160.054
regulation of body fluid levelsGO:00508781620.054
response to interleukin 4GO:0070670230.054
positive regulation of exocytosisGO:0045921200.054
positive regulation of cell migrationGO:00303351090.053
fatty acid derivative transportGO:1901571140.053
innate immune response activating signal transductionGO:0002758500.053
detection of yeastGO:000187920.053
myeloid dendritic cell differentiationGO:0043011160.053
cellular divalent inorganic cation homeostasisGO:00725031270.053
transmission of nerve impulseGO:0019226760.052
lipid localizationGO:00108761260.052
positive regulation of t cell differentiationGO:0045582520.051
protein catabolic processGO:00301632210.051
regulation of cell motilityGO:20001452360.050
Mouse
cell fate commitmentGO:00451652100.049
cell recognitionGO:0008037830.049
anion transportGO:00068201770.049
fatty acid transportGO:0015908280.049
cellular response to acid chemicalGO:0071229680.048
inner cell mass cell proliferationGO:0001833150.048
hypersensitivityGO:0002524100.048
regulation of exocytosisGO:0017157610.048
positive regulation of reactive oxygen species biosynthetic processGO:190342820.048
sensitizationGO:004696020.048
regulation of blood pressureGO:0008217930.047
defense response to virusGO:0051607680.047
ensheathment of neuronsGO:0007272760.047
protein kinase b signalingGO:0043491740.047
positive regulation of behaviorGO:0048520400.046
gamma delta t cell activationGO:0046629130.046
negative regulation of lymphocyte apoptotic processGO:0070229240.046
hormone secretionGO:00468791280.046
blood circulationGO:00080151950.046
negative regulation of cellular amino acid metabolic processGO:004576300.046
regulation of t helper 1 type immune responseGO:0002825170.045
pallium developmentGO:00215431200.045
acute inflammatory responseGO:0002526410.045
regulation of anion transportGO:0044070270.045
negative regulation of defense responseGO:0031348770.045
regulation of leukocyte apoptotic processGO:2000106560.045
negative regulation of immune effector processGO:0002698550.045
Mouse
lymphocyte proliferationGO:00466511640.045
glycoprotein biosynthetic processGO:0009101890.044
smoothened signaling pathwayGO:00072241050.044
regulation of phospholipase c activityGO:190027430.043
positive regulation of hormone secretionGO:0046887380.043
response to organonitrogen compoundGO:00102432460.043
Mouse
nucleobase containing small molecule metabolic processGO:00550863520.042
regulation of ion transportGO:00432692150.042
regulation of interleukin 2 biosynthetic processGO:0045076130.041
regulation of immunoglobulin mediated immune responseGO:0002889370.041
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.041
regulation of cysteine type endopeptidase activityGO:2000116650.040
myeloid dendritic cell activationGO:0001773250.040
oxidation reduction processGO:00551143420.040
regulation of peptide hormone secretionGO:0090276750.040
positive regulation of gliogenesisGO:0014015270.040
regulation of ion homeostasisGO:2000021640.040
membrane invaginationGO:0010324170.039
epithelial cell proliferationGO:00506731740.039
action potentialGO:0001508780.039
angiogenesisGO:00015252010.039
signal transduction in absence of ligandGO:0038034550.039
negative regulation of phosphate metabolic processGO:00459361840.039
positive regulation of alpha beta t cell differentiationGO:0046638280.039
regulation of hormone levelsGO:00108172110.039
positive regulation of peptidyl tyrosine phosphorylationGO:0050731610.038
positive regulation of nervous system developmentGO:00519622210.038
positive regulation of cell motilityGO:20001471160.038
corticotropin releasing hormone secretionGO:004339620.038
cellular response to biotic stimulusGO:0071216920.037
positive regulation of protein modification processGO:00314012990.037
regulation of cell projection organizationGO:00313442060.037
multicellular organismal homeostasisGO:00488711640.037
regulation of cellular catabolic processGO:00313292420.037
negative regulation of innate immune responseGO:0045824170.037
regulation of immunological synapse formationGO:200052020.036
regulation of phagocytosisGO:0050764330.036
blood vessel morphogenesisGO:00485142850.036
lipid transportGO:0006869980.036
interleukin 8 productionGO:003263740.036
amide transportGO:00428861380.036
regulation of endopeptidase activityGO:0052548890.036
tissue remodelingGO:00487711020.036
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.036
regulation of purine nucleotide metabolic processGO:19005421690.035
forebrain cell migrationGO:0021885580.035
epithelial tube morphogenesisGO:00605623030.035
cerebral cortex developmentGO:0021987860.035
negative regulation of leukocyte apoptotic processGO:2000107310.035
negative regulation of t cell activationGO:0050868650.035
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.035
negative regulation of synapse assemblyGO:005196430.035
dendritic cell chemotaxisGO:000240770.035
regulation of endocytosisGO:0030100690.035
regulation of glial cell differentiationGO:0045685410.035
regulation of calcium ion transport into cytosolGO:0010522310.035
hexose transportGO:0008645560.034
positive regulation of oligodendrocyte differentiationGO:004871490.034
negative regulation of protein modification processGO:00314001630.034
striated muscle tissue developmentGO:00147062930.034
positive regulation of type iii hypersensitivityGO:000180530.034
regulation of reactive oxygen species biosynthetic processGO:190342620.034
regulation of peptidase activityGO:0052547960.034
interleukin 1 productionGO:0032612310.034
regulation of corticotropin releasing hormone secretionGO:004339720.034
olfactory learningGO:000835520.034
positive regulation of gamma delta t cell differentiationGO:004558860.034
regulation of toll like receptor 4 signaling pathwayGO:003414340.033
immune response inhibiting cell surface receptor signaling pathwayGO:000276730.033
regulation of nucleocytoplasmic transportGO:0046822730.033
defense response to gram positive bacteriumGO:0050830500.033
positive regulation of purine nucleotide metabolic processGO:19005441140.033
regulation of protein kinase activityGO:00458592320.033
positive regulation of response to woundingGO:1903036660.033
sequestering of metal ionGO:0051238190.033
t cell tolerance inductionGO:000251760.033
t cell migrationGO:0072678190.033
glycoprotein metabolic processGO:00091001160.032
aromatic compound catabolic processGO:00194392860.032
regulation of systemic arterial blood pressure mediated by a chemical signalGO:0003044330.032
positive regulation of glial cell differentiationGO:0045687210.032
regulation of hypersensitivityGO:0002883100.032
positive regulation of protein secretionGO:0050714520.032
defense response to gram negative bacteriumGO:0050829280.032
positive regulation of leukocyte differentiationGO:1902107860.032
regulation of acute inflammatory response to antigenic stimulusGO:0002864100.032
regulation of mast cell activation involved in immune responseGO:0033006170.031
Mouse
stress activated protein kinase signaling cascadeGO:0031098810.031
regulation of nucleotide metabolic processGO:00061401690.031
muscle fiber developmentGO:0048747760.031
regulation of stress activated mapk cascadeGO:0032872690.031
negative regulation of apoptotic signaling pathwayGO:20012341040.031
guanosine containing compound catabolic processGO:19010691440.031
homeostasis of number of cellsGO:00488722100.031
neuronal action potentialGO:0019228540.031
single organism cell adhesionGO:00986021560.031
Mouse
establishment of protein localization to organelleGO:00725941180.031
positive regulation of b cell activationGO:0050871490.031
cellular calcium ion homeostasisGO:00068741190.031
regulation of reactive oxygen species metabolic processGO:2000377400.031
lymphocyte activation involved in immune responseGO:0002285930.031
regulation of cell adhesionGO:00301551540.030
release of sequestered calcium ion into cytosolGO:0051209420.030
immune response inhibiting signal transductionGO:000276540.030
telencephalon developmentGO:00215371860.030
engulfment of apoptotic cellGO:004365230.030
necroptotic signaling pathwayGO:009752730.030
acute inflammatory response to antigenic stimulusGO:0002438120.030
regulation of proteolysisGO:00301621640.030
canonical wnt signaling pathwayGO:00600701300.030
positive regulation of mast cell degranulationGO:0043306100.030
regulation of platelet activationGO:0010543170.030
regulation of leukocyte proliferationGO:00706631210.030
positive regulation of isotype switching to igg isotypesGO:004830470.029
regulation of neutrophil chemotaxisGO:0090022140.029
fatty acid biosynthetic processGO:0006633410.029
labyrinthine layer developmentGO:0060711490.029
regulation of protein targetingGO:1903533610.029
negative regulation of leukocyte mediated immunityGO:0002704290.029
inflammatory cell apoptotic processGO:0006925110.029
humoral immune responseGO:0006959570.029

Itk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:291400.182
disease of anatomical entityDOID:700.182
hypersensitivity reaction diseaseDOID:006005600.103
disease of cellular proliferationDOID:1456600.036
cancerDOID:16200.036
musculoskeletal system diseaseDOID:1700.036