Mus musculus

179 known processes

Wfs1

Wolfram syndrome 1 homolog (human)

(Aliases: wolframin,AI481085)

Wfs1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ion transmembrane transportGO:00342203610.155
cation transportGO:00068123990.116
Human
transmembrane transportGO:00550854120.083
cation transmembrane transportGO:00986552660.074
nucleotide metabolic processGO:00091173320.071
ossificationGO:00015032160.068
endomembrane system organizationGO:00102561470.065
intracellular protein transportGO:00068862040.063
regulation of cellular amine metabolic processGO:0033238200.060
anion transportGO:00068201770.052
negative regulation of cell proliferationGO:00082852960.052
male gamete generationGO:00482322850.051
amine metabolic processGO:0009308450.047
regulation of neuron differentiationGO:00456642810.047
cellular amine metabolic processGO:0044106440.047
cellular amino acid metabolic processGO:00065201030.046
regulation of neuron projection developmentGO:00109751690.046
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.045
synaptic transmissionGO:00072683290.044
membrane organizationGO:00610242450.044
aromatic compound catabolic processGO:00194392860.043
nucleobase containing small molecule metabolic processGO:00550863520.043
cellular ketone metabolic processGO:0042180840.043
purine nucleoside triphosphate metabolic processGO:00091442260.043
developmental maturationGO:00217001930.042
nucleoside phosphate metabolic processGO:00067533380.042
regulation of organelle organizationGO:00330432890.041
inorganic ion transmembrane transportGO:00986602340.039
cytoplasmic transportGO:00164822340.039
positive regulation of cellular amino acid metabolic processGO:004576430.039
regulation of cellular component biogenesisGO:00440871810.039
regionalizationGO:00030023370.038
ribose phosphate metabolic processGO:00196932910.037
organic cyclic compound catabolic processGO:19013612950.037
inorganic cation transmembrane transportGO:00986622070.036
organonitrogen compound catabolic processGO:19015652640.036
organophosphate catabolic processGO:00464342320.036
regulation of cell projection organizationGO:00313442060.035
positive regulation of cellular amine metabolic processGO:003324050.035
axonogenesisGO:00074092740.035
negative regulation of cellular component organizationGO:00511291940.035
regulation of hydrolase activityGO:00513362460.035
regulation of secretionGO:00510462740.035
purine nucleoside catabolic processGO:00061522050.035
ras protein signal transductionGO:0007265770.034
response to radiationGO:00093141650.034
positive regulation of nervous system developmentGO:00519622210.034
apoptotic signaling pathwayGO:00971903060.034
macromolecule catabolic processGO:00090572810.033
purine nucleotide metabolic processGO:00061633020.033
response to growth factorGO:00708481980.033
glycosyl compound catabolic processGO:19016582060.033
positive regulation of programmed cell deathGO:00430682180.033
carbohydrate derivative catabolic processGO:19011362310.032
localization within membraneGO:005166840.032
oxidation reduction processGO:00551143420.032
positive regulation of apoptotic processGO:00430652170.032
positive regulation of organelle organizationGO:00106381280.032
negative regulation of intracellular signal transductionGO:19025321670.031
glycosyl compound metabolic processGO:19016572460.031
ribonucleotide catabolic processGO:00092612080.031
regulation of protein localizationGO:00328802310.031
negative regulation of molecular functionGO:00440922580.031
purine ribonucleoside triphosphate metabolic processGO:00092052200.031
purine containing compound catabolic processGO:00725232130.031
cellular response to growth factor stimulusGO:00713631970.031
mapk cascadeGO:00001652810.030
neurotransmitter transportGO:0006836760.029
cell adhesionGO:00071553290.029
purine ribonucleotide metabolic processGO:00091502900.028
regulation of cellular amino acid metabolic processGO:000652150.028
regulation of defense responseGO:00313472330.028
ribonucleotide metabolic processGO:00092592910.028
organelle localizationGO:00516401790.028
carbohydrate derivative biosynthetic processGO:19011371830.028
cellular nitrogen compound catabolic processGO:00442702800.028
regulation of protein transportGO:00512231630.028
ribonucleoside triphosphate metabolic processGO:00091992200.027
negative regulation of phosphate metabolic processGO:00459361840.027
divalent inorganic cation transportGO:00725111780.027
Human
sodium ion transportGO:0006814730.027
regulation of secretion by cellGO:19035302490.027
cellular chemical homeostasisGO:00550822150.027
Human
regulation of transmembrane transportGO:00347621280.026
nitrogen compound transportGO:00717052710.026
spermatogenesisGO:00072832840.026
positive regulation of cell developmentGO:00107202370.026
purine containing compound metabolic processGO:00725213110.026
positive regulation of protein modification processGO:00314012990.026
organelle assemblyGO:00709251770.026
gland developmentGO:00487323300.026
exocytosisGO:00068871210.026
meiotic cell cycleGO:00513211220.026
divalent metal ion transportGO:00708381720.025
Human
cellular lipid metabolic processGO:00442553230.025
negative regulation of growthGO:0045926990.025
sensory perceptionGO:00076002450.025
Human
purine ribonucleoside catabolic processGO:00461302050.025
nucleoside triphosphate catabolic processGO:00091432050.025
protein catabolic processGO:00301632210.025
organic acid transportGO:00158491010.025
t cell activationGO:00421102890.025
acetylcholine transportGO:001587020.024
response to oxidative stressGO:00069791230.024
ribonucleoside metabolic processGO:00091192450.024
cellular homeostasisGO:00197252400.024
Human
endocytosisGO:00068971680.024
cognitionGO:00508901490.024
heterocycle catabolic processGO:00467002800.023
purine ribonucleoside triphosphate catabolic processGO:00092071990.023
calcium ion transportGO:00068161590.023
Human
regulation of establishment of protein localizationGO:00702011810.023
digestive system developmentGO:00551232000.023
forebrain developmentGO:00309003020.023
nucleoside metabolic processGO:00091162460.023
locomotory behaviorGO:00076261950.023
regulation of exocytosisGO:0017157610.023
negative regulation of phosphorus metabolic processGO:00105631840.023
cell growthGO:00160491300.023
nucleoside catabolic processGO:00091642060.023
regulation of ion transportGO:00432692150.023
Human
regulation of cell cycleGO:00517262810.023
small gtpase mediated signal transductionGO:0007264970.023
learning or memoryGO:00076111480.023
muscle system processGO:00030121410.022
regulation of cell growthGO:0001558910.022
nucleotide catabolic processGO:00091662170.022
rhodopsin mediated signaling pathwayGO:001605640.022
multicellular organismal homeostasisGO:00488711640.022
protein modification by small protein conjugationGO:00324461870.022
organic hydroxy compound metabolic processGO:19016152030.022
cellular protein complex assemblyGO:00436231160.022
positive regulation of cell deathGO:00109422240.022
purine nucleoside metabolic processGO:00422782410.022
regulation of cellular response to growth factor stimulusGO:0090287820.021
protein localization to membraneGO:00726571080.021
regulation of cell motilityGO:20001452360.021
protein targetingGO:00066051430.021
regulation of cellular catabolic processGO:00313292420.021
carboxylic acid transportGO:00469421000.021
positive regulation of protein phosphorylationGO:00019342420.021
regulation of anatomical structure sizeGO:00900661780.021
connective tissue developmentGO:00614481790.021
response to organonitrogen compoundGO:00102432460.021
peptidyl amino acid modificationGO:00181933360.021
regulation of cellular ketone metabolic processGO:0010565660.020
negative regulation of cellular catabolic processGO:0031330470.020
nucleocytoplasmic transportGO:00069131390.020
respiratory system developmentGO:00605411900.020
nucleoside monophosphate metabolic processGO:0009123850.020
purine ribonucleoside metabolic processGO:00461282410.020
regulation of cell activationGO:00508652890.020
striated muscle tissue developmentGO:00147062930.020
regulation of apoptotic signaling pathwayGO:20012331970.020
g protein coupled receptor signaling pathwayGO:00071862430.020
positive regulation of cellular catabolic processGO:00313311480.020
regulation of ion transmembrane transporter activityGO:0032412540.020
purine nucleotide catabolic processGO:00061952110.020
regulation of transferase activityGO:00513382630.020
skeletal system developmentGO:00015013560.020
dephosphorylationGO:00163111290.020
regulation of kinase activityGO:00435492490.020
regulation of ossificationGO:00302781120.020
myeloid cell differentiationGO:00300992330.019
metal ion homeostasisGO:00550651890.019
Human
carbohydrate metabolic processGO:00059752300.019
amino acid transmembrane transportGO:0003333370.019
regulation of nucleotide catabolic processGO:00308111220.019
purine ribonucleotide catabolic processGO:00091542080.019
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.019
chemotaxisGO:00069352470.019
regulation of vesicle mediated transportGO:00606271390.019
cell maturationGO:00484691270.019
proteolysis involved in cellular protein catabolic processGO:00516031470.019
regulation of system processGO:00440572000.019
neuromuscular processGO:0050905990.019
camera type eye developmentGO:00430102660.019
establishment of vesicle localizationGO:0051650810.019
rho protein signal transductionGO:0007266320.019
lymphocyte proliferationGO:00466511640.018
regulation of protein serine threonine kinase activityGO:00719001570.018
muscle contractionGO:00069361010.018
negative regulation of protein metabolic processGO:00512482820.018
vesicle localizationGO:0051648860.018
epithelial tube morphogenesisGO:00605623030.018
microtubule based processGO:00070172360.018
ubiquitin dependent protein catabolic processGO:00065111290.018
regulation of ion transmembrane transportGO:00347651190.018
dna metabolic processGO:00062593030.018
sequestering of calcium ionGO:0051208180.018
regulation of cell morphogenesis involved in differentiationGO:00107691510.018
negative regulation of cell developmentGO:00107211690.018
muscle tissue developmentGO:00605373080.018
ventricular cardiac muscle cell action potentialGO:008600540.018
protein localization to organelleGO:00333651850.018
regulation of metal ion transportGO:00109591060.018
Human
regulation of protein catabolic processGO:00421761080.018
plasma membrane organizationGO:0007009900.017
organic anion transportGO:00157111370.017
purine nucleoside triphosphate catabolic processGO:00091462030.017
regulation of multi organism processGO:00439001110.017
striated muscle contractionGO:0006941450.017
actin cytoskeleton organizationGO:00300362200.017
positive regulation of neuron projection developmentGO:0010976790.017
compound eye developmentGO:004874910.017
anatomical structure homeostasisGO:00602491450.017
nucleoside phosphate catabolic processGO:19012922220.017
metencephalon developmentGO:0022037890.017
regulation of lymphocyte activationGO:00512492400.017
leukocyte differentiationGO:00025213420.017
morphogenesis of a branching structureGO:00017632030.017
cation homeostasisGO:00550802120.017
Human
regulation of intracellular transportGO:00323861590.017
meiotic nuclear divisionGO:00071261150.017
nuclear transportGO:00511691390.017
cytokine productionGO:00018163190.017
reactive oxygen species metabolic processGO:0072593840.017
protein localization to nucleusGO:00345041210.017
positive regulation of cell motilityGO:20001471160.016
cardiac muscle cell contractionGO:008600370.016
regulation of cytokine productionGO:00018172660.016
cellular response to epidermal growth factor stimulusGO:007136440.016
regulation of nucleoside metabolic processGO:00091181300.016
muscle cell differentiationGO:00426922610.016
embryonic organ morphogenesisGO:00485622760.016
negative regulation of immune system processGO:00026832090.016
myeloid leukocyte differentiationGO:00025731190.016
immune effector processGO:00022523210.016
pole plasm assemblyGO:000731520.016
organelle fissionGO:00482851700.016
positive regulation of neuron differentiationGO:00456661410.016
pigmentationGO:0043473710.016
intracellular mrna localizationGO:000829840.016
regulation of mapk cascadeGO:00434082480.016
establishment of mitochondrion localizationGO:005165440.016
cellular response to organonitrogen compoundGO:00714171450.016
acetate ester transportGO:190137420.016
regulation of proteolysisGO:00301621640.016
sequestering of metal ionGO:0051238190.016
regulation of hormone levelsGO:00108172110.016
positive regulation of cellular component biogenesisGO:0044089940.016
calcium ion transmembrane transportGO:0070588850.016
nuclear divisionGO:00002801580.016
regulation of membrane potentialGO:00423911920.016
vesicle organizationGO:0016050600.015
cellular divalent inorganic cation homeostasisGO:00725031270.015
Human
negative regulation of nervous system developmentGO:00519611560.015
regulation of purine nucleotide metabolic processGO:19005421690.015
l amino acid transportGO:0015807320.015
ribonucleoside catabolic processGO:00424542060.015
protein maturationGO:00516041760.015
striated muscle myosin thick filament assemblyGO:007168810.015
acetylcholine secretion neurotransmissionGO:001405520.015
regulation of transporter activityGO:0032409570.015
homeostasis of number of cellsGO:00488722100.015
nucleoside triphosphate metabolic processGO:00091412300.015
synapse organizationGO:00508081250.015
positive regulation of defense responseGO:00313491240.015
glycoprotein biosynthetic processGO:0009101890.015
establishment of organelle localizationGO:00516561220.015
mitochondrion distributionGO:004831140.015
negative regulation of cellular protein metabolic processGO:00322692470.015
germ cell developmentGO:00072811850.015
inflammatory responseGO:00069542440.015
positive regulation of protein catabolic processGO:0045732600.015
negative regulation of cell cycleGO:00457861230.015
b cell activationGO:00421131610.015
regulation of protein complex assemblyGO:0043254830.015
innate immune responseGO:00450871570.015
lateral inhibitionGO:004633110.015
regulation of protein kinase activityGO:00458592320.015
lateral line system developmentGO:004892510.015
regulation of cell cycle processGO:00105641600.015
regulation of cell migrationGO:00303342190.014
response to lipopolysaccharideGO:00324961280.014
negative regulation of protein modification processGO:00314001630.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.014
biomineral tissue developmentGO:0031214640.014
cellular metal ion homeostasisGO:00068751510.014
Human
l alpha amino acid transmembrane transportGO:1902475230.014
oocyte axis specificationGO:000730920.014
regulation of neurotransmitter levelsGO:0001505870.014
bone developmentGO:00603481200.014
regulation of t cell activationGO:00508631700.014
regulation of intracellular protein transportGO:0033157820.014
ribonucleoside monophosphate metabolic processGO:0009161800.014
protein processingGO:00164851630.014
morphogenesis of a branching epitheliumGO:00611381930.014
regulation of leukocyte differentiationGO:19021051590.014
heart contractionGO:0060047930.014
cell type specific apoptotic processGO:00972852680.014
action potentialGO:0001508780.014
angiogenesisGO:00015252010.014
maintenance of locationGO:0051235890.014
cellular component assembly involved in morphogenesisGO:00109271390.014
atp metabolic processGO:0046034750.014
stem cell differentiationGO:00488632680.014
organophosphate biosynthetic processGO:00904071220.014
neuron projection guidanceGO:00974851410.014
ribonucleoside triphosphate catabolic processGO:00092031990.014
meiotic cell cycle processGO:1903046770.014
leukocyte migrationGO:00509001240.014
cellular macromolecule catabolic processGO:00442652060.014
negative regulation of phosphorylationGO:00423261660.013
cellular ion homeostasisGO:00068731650.013
Human
positive regulation of protein kinase activityGO:00458601440.013
extracellular matrix organizationGO:00301981470.013
memoryGO:0007613580.013
positive regulation of nucleotide metabolic processGO:00459811140.013
positive regulation of cell migrationGO:00303351090.013
oocyte constructionGO:000730820.013
maternal determination of anterior posterior axis embryoGO:000835820.013
blood vessel morphogenesisGO:00485142850.013
extracellular structure organizationGO:00430621480.013
blood circulationGO:00080151950.013
tissue remodelingGO:00487711020.013
gtp catabolic processGO:00061841430.013
wnt signaling pathwayGO:00160551880.013
golgi vesicle transportGO:0048193300.013
organonitrogen compound biosynthetic processGO:19015661920.013
sensory system developmentGO:004888030.013
neurotransmitter secretionGO:0007269620.013
glycoprotein metabolic processGO:00091001160.013
neuron neuron synaptic transmissionGO:0007270690.013
protein localization to plasma membraneGO:0072659570.013
regulation of nucleotide metabolic processGO:00061401690.013
tube formationGO:00351481400.013
positive regulation of hydrolase activityGO:00513451480.013
purine ribonucleoside monophosphate metabolic processGO:0009167800.013
digestive tract morphogenesisGO:00485461470.013
negative regulation of purine nucleotide catabolic processGO:003312290.013
leukocyte proliferationGO:00706611720.013
posttranscriptional regulation of gene expressionGO:00106081550.013
mitochondrion organizationGO:00070051340.013
retrograde vesicle mediated transport golgi to erGO:000689010.013
nuclear importGO:0051170950.013
cytoskeleton dependent intracellular transportGO:0030705500.013
regulation of body fluid levelsGO:00508781620.013
Human
protein glycosylationGO:0006486550.013
negative regulation of wnt signaling pathwayGO:0030178730.013
glucose homeostasisGO:00425931280.013
Human
positive regulation of purine nucleotide metabolic processGO:19005441140.013
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.013
organic hydroxy compound transportGO:0015850930.013
positive regulation of secretion by cellGO:19035321140.013
negative regulation of apoptotic signaling pathwayGO:20012341040.013
myosin filament assemblyGO:003103420.013
response to extracellular stimulusGO:00099911270.012
regulation of cytoskeleton organizationGO:00514931220.012
pallium developmentGO:00215431200.012
positive regulation of kinase activityGO:00336741550.012
anion transmembrane transportGO:0098656710.012
lipid biosynthetic processGO:00086101790.012
regulation of organ morphogenesisGO:20000271440.012
myosin filament organizationGO:003103330.012
skin developmentGO:00435882200.012
modification dependent protein catabolic processGO:00199411330.012
dendrite developmentGO:00163581150.012
glycosylationGO:0070085620.012
establishment or maintenance of cytoskeleton polarityGO:003095220.012
telencephalon developmentGO:00215371860.012
vacuole organizationGO:0007033380.012
macromolecule glycosylationGO:0043413550.012
response to inorganic substanceGO:0010035960.012
defense response to other organismGO:00985421970.012
regulation of actin filament based processGO:0032970990.012
regulation of synaptic growth at neuromuscular junctionGO:000858240.012
protein import into nucleusGO:0006606950.012
t cell proliferationGO:00420981200.012
positive regulation of cell cycleGO:0045787920.012
cellular response to oxidative stressGO:0034599760.012
spermatid differentiationGO:00485151150.012
positive regulation of proteolysisGO:0045862850.012
sulfur compound metabolic processGO:00067901000.012
synaptic vesicle transportGO:0048489570.012
microtubule based transportGO:0010970500.012
engulfment of apoptotic cellGO:004365230.012
regulation of wnt signaling pathwayGO:00301111230.012
chondrocyte differentiationGO:0002062720.012
response to molecule of bacterial originGO:00022371430.012
positive regulation of lymphocyte activationGO:00512511400.012
cerebellum developmentGO:0021549770.012
cell substrate adhesionGO:00315891300.012
wound healingGO:00420601570.012
telencephalon cell migrationGO:0022029550.012
protein modification by small protein conjugation or removalGO:00706472070.012
regulation of purine nucleotide catabolic processGO:00331211220.012
rhythmic processGO:00485111740.012
calcium ion homeostasisGO:00550741270.012
Human
regulation of muscle contractionGO:0006937490.012
female gamete generationGO:0007292740.012
amino acid transportGO:0006865610.012
protein importGO:00170381010.012
positive regulation of transferase activityGO:00513471670.012
cellular response to dna damage stimulusGO:00069742070.012
purine nucleoside monophosphate metabolic processGO:0009126810.012
protein ubiquitinationGO:00165671710.012
extrinsic apoptotic signaling pathwayGO:00971911260.012
establishment of protein localization to organelleGO:00725941180.012
cell chemotaxisGO:0060326810.012
regulation of lymphocyte proliferationGO:00506701170.012
positive regulation of cell adhesionGO:0045785800.012
regulation of epithelial cell proliferationGO:00506781410.012
cellular response to hormone stimulusGO:00328701500.011
retrograde transport endosome to golgiGO:004214720.011
inter male aggressive behaviorGO:000212130.011
lipid transportGO:0006869980.011
renal system developmentGO:00720012250.011
Human
microtubule based movementGO:0007018840.011
sensory organ morphogenesisGO:00905962420.011
regulation of mitochondrial fissionGO:009014030.011
multi multicellular organism processGO:00447061090.011
digestive tract developmentGO:00485651900.011
stem cell developmentGO:00488642190.011
tissue homeostasisGO:00018941150.011
modification dependent macromolecule catabolic processGO:00436321330.011
regulation of sequence specific dna binding transcription factor activityGO:00510901060.011
cellular calcium ion homeostasisGO:00068741190.011
Human
amide transportGO:00428861380.011
regulation of circadian rhythmGO:0042752580.011
regulation of homeostatic processGO:00328441820.011
regulation of mitotic cell cycleGO:00073461260.011
adaptive immune responseGO:00022501550.011
regulation of cellular component sizeGO:00325351210.011
cellular carbohydrate metabolic processGO:00442621190.011
heart morphogenesisGO:00030071780.011
intrinsic apoptotic signaling pathwayGO:00971931320.011
positive regulation of nucleotide catabolic processGO:0030813880.011
regulation of muscle system processGO:0090257800.011
erk1 and erk2 cascadeGO:0070371770.011
hormone secretionGO:00468791280.011
heart processGO:0003015940.011
ameboidal type cell migrationGO:00016671280.011
single organism cell adhesionGO:00986021560.011
inclusion body assemblyGO:007084130.011
cellular response to arsenic containing substanceGO:007124340.011
epithelial cell proliferationGO:00506731740.011
single organism nuclear importGO:1902593950.011
response to endoplasmic reticulum stressGO:0034976530.011
response to transforming growth factor betaGO:0071559880.011
negative regulation of cellular amine metabolic processGO:003323910.011
copii coated vesicle buddingGO:009011420.010
nucleotide biosynthetic processGO:0009165780.010
fibroblast growth factor receptor signaling pathwayGO:0008543460.010
activation of mapkkk activityGO:000018510.010
regulation of feeding behaviorGO:006025930.010
smoothened signaling pathwayGO:00072241050.010
cellular response to cytokine stimulusGO:00713451890.010
negative regulation of cell activationGO:00508661110.010
circulatory system processGO:00030131970.010
establishment of synaptic vesicle localizationGO:0097480570.010
positive regulation of necrotic cell deathGO:001094010.010
positive regulation of atpase activityGO:003278130.010
cell matrix adhesionGO:0007160680.010
cellular response to biotic stimulusGO:0071216920.010
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:004316230.010
positive regulation of secretionGO:00510471300.010
response to epidermal growth factorGO:007084940.010
nucleoside phosphate biosynthetic processGO:1901293790.010
response to peptideGO:19016521360.010
response to organic cyclic compoundGO:00140701980.010
positive regulation of protein serine threonine kinase activityGO:00719021060.010
regulation of synaptic plasticityGO:0048167870.010
regulation of removal of superoxide radicalsGO:200012140.010
atp catabolic processGO:0006200550.010
appendage developmentGO:00487361660.010

Wfs1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
muscle tissue diseaseDOID:6600.059
disease of anatomical entityDOID:700.059
muscular diseaseDOID:008000000.059
musculoskeletal system diseaseDOID:1700.059
myopathyDOID:42300.053
cardiovascular system diseaseDOID:128700.038
inherited metabolic disorderDOID:65500.034
disease of metabolismDOID:001466700.034
Human
immune system diseaseDOID:291400.031
heart diseaseDOID:11400.023
cardiomyopathyDOID:005070000.020
intrinsic cardiomyopathyDOID:006003600.020
nervous system diseaseDOID:86300.020
neuromuscular diseaseDOID:44000.018
neuropathyDOID:87000.018
central nervous system diseaseDOID:33100.013
hematopoietic system diseaseDOID:7400.012
charcot marie tooth diseaseDOID:1059500.011