Mus musculus

96 known processes

Rock1

Rho-associated coiled-coil containing protein kinase 1

(Aliases: 1110055K06Rik,Rock-I)

Rock1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
purine ribonucleoside catabolic processGO:00461302050.852
nucleoside catabolic processGO:00091642060.720
nucleoside triphosphate catabolic processGO:00091432050.665
actin cytoskeleton organizationGO:00300362200.619
purine ribonucleotide metabolic processGO:00091502900.583
organophosphate catabolic processGO:00464342320.580
small gtpase mediated signal transductionGO:0007264970.567
Rat Fly
nucleotide catabolic processGO:00091662170.530
ribonucleotide catabolic processGO:00092612080.518
epithelial cell developmentGO:00020641590.475
organonitrogen compound catabolic processGO:19015652640.470
aromatic compound catabolic processGO:00194392860.468
cellular nitrogen compound catabolic processGO:00442702800.421
nucleotide metabolic processGO:00091173320.402
regulation of nucleoside metabolic processGO:00091181300.387
nucleoside metabolic processGO:00091162460.385
carbohydrate derivative catabolic processGO:19011362310.375
glycosyl compound catabolic processGO:19016582060.374
regulation of nucleotide metabolic processGO:00061401690.343
negative regulation of molecular functionGO:00440922580.333
regulation of neuron projection developmentGO:00109751690.326
Fly
glycosyl compound metabolic processGO:19016572460.322
ras protein signal transductionGO:0007265770.314
Rat Fly
nucleoside phosphate catabolic processGO:19012922220.305
regulation of hydrolase activityGO:00513362460.295
purine ribonucleoside triphosphate catabolic processGO:00092071990.292
purine ribonucleoside metabolic processGO:00461282410.290
guanosine containing compound catabolic processGO:19010691440.289
regulation of ras protein signal transductionGO:00465781140.289
purine nucleoside triphosphate catabolic processGO:00091462030.288
gtp catabolic processGO:00061841430.278
organelle localizationGO:00516401790.270
Mouse Fly
purine nucleoside metabolic processGO:00422782410.268
ribose phosphate metabolic processGO:00196932910.267
synaptic vesicle localizationGO:0097479590.263
ribonucleoside triphosphate metabolic processGO:00091992200.263
guanosine containing compound metabolic processGO:19010681440.258
cytokinesisGO:0000910170.248
Fly
cell divisionGO:00513011200.247
Fly
nucleobase containing small molecule metabolic processGO:00550863520.228
nucleoside phosphate metabolic processGO:00067533380.228
organic cyclic compound catabolic processGO:19013612950.226
ribonucleoside metabolic processGO:00091192450.225
purine nucleoside triphosphate metabolic processGO:00091442260.222
purine containing compound catabolic processGO:00725232130.220
establishment of organelle localizationGO:00516561220.210
Mouse Fly
purine nucleotide metabolic processGO:00061633020.203
ribonucleoside triphosphate catabolic processGO:00092031990.192
positive regulation of gtpase activityGO:0043547850.188
purine nucleotide catabolic processGO:00061952110.188
heterocycle catabolic processGO:00467002800.183
cell cell junction organizationGO:0045216720.182
purine ribonucleoside triphosphate metabolic processGO:00092052200.173
regulation of cell migrationGO:00303342190.172
regulation of gtp catabolic processGO:00331241130.169
regulation of cell motilityGO:20001452360.160
positive regulation of gtp catabolic processGO:0033126850.158
positive regulation of purine nucleotide metabolic processGO:19005441140.154
purine ribonucleotide catabolic processGO:00091542080.151
regulation of nucleotide catabolic processGO:00308111220.148
regulation of cellular ketone metabolic processGO:0010565660.146
regulation of purine nucleotide metabolic processGO:19005421690.146
negative regulation of cell proliferationGO:00082852960.145
positive regulation of cellular catabolic processGO:00313311480.143
purine containing compound metabolic processGO:00725213110.140
cell junction organizationGO:0034330770.138
regulation of purine nucleotide catabolic processGO:00331211220.137
posttranscriptional regulation of gene expressionGO:00106081550.131
body morphogenesisGO:0010171450.131
Worm
purine nucleoside catabolic processGO:00061522050.131
negative regulation of protein metabolic processGO:00512482820.129
blood vessel morphogenesisGO:00485142850.125
Human
establishment of vesicle localizationGO:0051650810.115
ribonucleotide metabolic processGO:00092592910.115
regulation of cell projection organizationGO:00313442060.114
Fly
microtubule cytoskeleton organizationGO:00002261570.111
Mouse Fly
cellular amine metabolic processGO:0044106440.109
development of primary sexual characteristicsGO:00451371430.103
gland developmentGO:00487323300.099
regulation of vesicle mediated transportGO:00606271390.088
organelle fissionGO:00482851700.087
Fly
positive regulation of neuron differentiationGO:00456661410.087
circadian regulation of gene expressionGO:0032922480.087
plus end directed organelle transport along microtubuleGO:007238620.085
positive regulation of nucleoside metabolic processGO:0045979910.084
regulation of ion transportGO:00432692150.083
regulation of cell cycle processGO:00105641600.082
Mouse
nucleoside triphosphate metabolic processGO:00091412300.078
dephosphorylationGO:00163111290.078
negative regulation of hydrolase activityGO:0051346710.077
cell type specific apoptotic processGO:00972852680.076
mitotic cell cycleGO:00002781950.074
Fly
regulation of cell shapeGO:0008360390.072
Worm Fly
positive regulation of purine nucleotide catabolic processGO:0033123880.072
positive regulation of ras gtpase activityGO:0032320650.071
oocyte constructionGO:000730820.067
Fly
positive regulation of nucleotide catabolic processGO:0030813880.067
positive regulation of nucleotide metabolic processGO:00459811140.067
microtubule based processGO:00070172360.065
Mouse Fly
organelle assemblyGO:00709251770.065
homeostasis of number of cellsGO:00488722100.065
skin developmentGO:00435882200.065
Human Fly
amine metabolic processGO:0009308450.064
regulation of mapk cascadeGO:00434082480.063
spermatogenesisGO:00072832840.062
synaptic vesicle transportGO:0048489570.061
positive regulation of cell deathGO:00109422240.061
regulation of cellular catabolic processGO:00313292420.061
positive regulation of kinase activityGO:00336741550.061
ribonucleoside catabolic processGO:00424542060.060
myeloid cell differentiationGO:00300992330.059
cellular amino acid metabolic processGO:00065201030.059
sensory organ morphogenesisGO:00905962420.058
Fly
regulation of neuron differentiationGO:00456642810.056
Fly
establishment of synaptic vesicle localizationGO:0097480570.056
angiogenesisGO:00015252010.055
Human
regulation of membrane potentialGO:00423911920.055
retina morphogenesis in camera type eyeGO:0060042450.054
regulation of protein kinase activityGO:00458592320.054
single organismal cell cell adhesionGO:00163371310.054
Human
axonogenesisGO:00074092740.052
Fly
nuclear divisionGO:00002801580.051
Fly
regulation of ion transmembrane transportGO:00347651190.051
cellular ketone metabolic processGO:0042180840.051
negative regulation of phosphate metabolic processGO:00459361840.051
exocytosisGO:00068871210.050
regulation of cell morphogenesis involved in differentiationGO:00107691510.049
Fly
gtp metabolic processGO:00460391440.048
cation transportGO:00068123990.048
regulation of kinase activityGO:00435492490.048
ameboidal type cell migrationGO:00016671280.046
ion transmembrane transportGO:00342203610.045
establishment or maintenance of cell polarityGO:0007163860.045
Fly
positive regulation of hydrolase activityGO:00513451480.045
regulation of cellular amino acid metabolic processGO:000652150.044
meiotic nuclear divisionGO:00071261150.044
neuron apoptotic processGO:00514021420.043
negative regulation of phosphorus metabolic processGO:00105631840.042
leukocyte differentiationGO:00025213420.042
lymphocyte proliferationGO:00466511640.041
regulation of cytoskeleton organizationGO:00514931220.041
Mouse Fly
maintenance of locationGO:0051235890.039
Fly
positive regulation of erk1 and erk2 cascadeGO:0070374470.038
regulation of cellular component sizeGO:00325351210.038
leukocyte proliferationGO:00706611720.038
synaptic transmissionGO:00072683290.038
negative regulation of intracellular signal transductionGO:19025321670.038
eye photoreceptor cell differentiationGO:0001754410.037
chromatin silencing at rdnaGO:000018330.037
membrane organizationGO:00610242450.037
endocytosisGO:00068971680.037
neural precursor cell proliferationGO:00613511210.036
regulation of response to woundingGO:19030341890.036
Fly
chromatin organizationGO:00063252060.035
positive regulation of apoptotic processGO:00430652170.034
muscle cell differentiationGO:00426922610.034
regulation of cell activationGO:00508652890.033
meiotic cell cycleGO:00513211220.033
appendage morphogenesisGO:00351071490.033
Fly
negative regulation of cellular protein metabolic processGO:00322692470.033
cell adhesionGO:00071553290.033
single organism cell adhesionGO:00986021560.033
Human
regulation of organelle organizationGO:00330432890.032
Mouse Fly
cell substrate adhesionGO:00315891300.032
cytokine productionGO:00018163190.032
gonad developmentGO:00084061410.032
endomembrane system organizationGO:00102561470.032
vesicle localizationGO:0051648860.031
regulation of body fluid levelsGO:00508781620.031
cellular chemical homeostasisGO:00550822150.031
nucleoside monophosphate metabolic processGO:0009123850.031
fat cell differentiationGO:00454441600.031
negative regulation of phosphorylationGO:00423261660.030
regulation of t cell activationGO:00508631700.030
positive regulation of nervous system developmentGO:00519622210.030
apical constrictionGO:000338340.030
regulation of secretionGO:00510462740.030
circulatory system processGO:00030131970.030
ribonucleoprotein complex subunit organizationGO:0071826280.030
cellular metal ion homeostasisGO:00068751510.030
multicellular organismal reproductive behaviorGO:0033057230.030
positive regulation of insulin receptor signaling pathwayGO:004662840.029
oogenesisGO:0048477560.029
Fly
bone morphogenesisGO:0060349780.029
heart contractionGO:0060047930.029
nucleus localizationGO:0051647200.029
Mouse Fly
blood circulationGO:00080151950.029
cellular ion homeostasisGO:00068731650.029
positive regulation of cell cycle g1 s phase transitionGO:190280890.028
regulation of metal ion transportGO:00109591060.028
jnk cascadeGO:0007254720.028
ribonucleoside monophosphate metabolic processGO:0009161800.027
regulation of ras gtpase activityGO:0032318880.027
regulation of cellular response to stressGO:00801351590.027
retina development in camera type eyeGO:00600411190.027
positive regulation of protein phosphorylationGO:00019342420.027
limb developmentGO:00601731660.027
b cell homeostasisGO:0001782340.027
negative regulation of synaptic vesicle exocytosisGO:200030130.026
regulation of secretion by cellGO:19035302490.026
regulation of endocytosisGO:0030100690.026
microtubule slidingGO:005101210.026
positive regulation of apoptotic signaling pathwayGO:2001235950.026
maintenance of location in cellGO:0051651240.026
Fly
cell maturationGO:00484691270.025
Fly
regulation of lymphocyte activationGO:00512492400.025
response to organonitrogen compoundGO:00102432460.025
mitotic nuclear divisionGO:0007067480.025
Fly
establishment of spindle localizationGO:0051293190.025
developmental growth involved in morphogenesisGO:00605601380.025
Fly
regulation of protein localizationGO:00328802310.025
Fly
regulation of transferase activityGO:00513382630.025
receptor mediated endocytosisGO:0006898510.025
regulation of cell divisionGO:0051302760.025
positive regulation of cell projection organizationGO:0031346950.025
ribonucleoside monophosphate catabolic processGO:0009158570.024
hematopoietic progenitor cell differentiationGO:00022441430.024
heart processGO:0003015940.024
mesodermal cell migrationGO:000807840.024
multi organism reproductive behaviorGO:0044705290.024
forebrain developmentGO:00309003020.024
plasma membrane organizationGO:0007009900.024
fertilizationGO:00095661270.023
atp catabolic processGO:0006200550.023
cell junction assemblyGO:0034329520.023
regulation of cell cycleGO:00517262810.023
Mouse
developmental maturationGO:00217001930.023
Fly
embryonic appendage morphogenesisGO:00351131260.023
germ cell developmentGO:00072811850.023
Fly
extrinsic apoptotic signaling pathwayGO:00971911260.023
Mouse
leukocyte homeostasisGO:0001776790.022
purine nucleoside monophosphate metabolic processGO:0009126810.022
negative regulation of transferase activityGO:0051348850.022
t cell activationGO:00421102890.022
camera type eye developmentGO:00430102660.022
regulation of synaptic transmission gabaergicGO:0032228170.022
positive regulation of cell developmentGO:00107202370.021
regulation of lymphocyte proliferationGO:00506701170.021
regulation of cellular amine metabolic processGO:0033238200.021
positive regulation of cellular amine metabolic processGO:003324050.021
mapk cascadeGO:00001652810.021
cell recognitionGO:0008037830.020
rab protein signal transductionGO:003248210.020
megakaryocyte differentiationGO:0030219260.020
female gamete generationGO:0007292740.020
Fly
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.020
Mouse
neurotransmitter secretionGO:0007269620.020
establishment of meiotic spindle orientationGO:005129610.020
generation of precursor metabolites and energyGO:00060911030.020
cellular protein complex assemblyGO:00436231160.020
negative regulation of protein processingGO:0010955790.020
axon guidanceGO:00074111410.020
purine ribonucleoside monophosphate metabolic processGO:0009167800.019
calcium ion homeostasisGO:00550741270.019
pigmentationGO:0043473710.019
positive regulation of cell cycle processGO:0090068610.019
Mouse
canonical wnt signaling pathwayGO:00600701300.019
regulation of cytokine productionGO:00018172660.019
regulation of transcription by chromatin organizationGO:003440100.019
regulation of neurotransmitter levelsGO:0001505870.019
spindle localizationGO:0051653220.019
membrane tubulationGO:009732040.019
activation of immune responseGO:00022531380.019
meiotic cell cycle processGO:1903046770.019
regulation of neurotransmitter secretionGO:0046928290.019
body fluid secretionGO:0007589530.019
osteoclast differentiationGO:0030316620.019
lymphocyte homeostasisGO:0002260640.019
negative regulation of kinase activityGO:0033673810.018
positive regulation of protein modification processGO:00314012990.018
regulation of peptidase activityGO:0052547960.018
rho protein signal transductionGO:0007266320.018
Rat Fly
regulation of leukocyte differentiationGO:19021051590.018
negative regulation of chromatin silencingGO:003193610.018
positive regulation of toll like receptor 4 signaling pathwayGO:003414510.018
epidermis developmentGO:00085441870.018
Human Fly
male gamete generationGO:00482322850.017
blastocyst developmentGO:0001824800.017
i kappab kinase nf kappab signalingGO:0007249850.017
protein localization to organelleGO:00333651850.017
negative regulation of protein phosphorylationGO:00019331260.017
multi multicellular organism processGO:00447061090.017
erk1 and erk2 cascadeGO:0070371770.017
wound healingGO:00420601570.017
Fly
positive regulation of myeloid cell apoptotic processGO:003303440.017
negative regulation of cellular amine metabolic processGO:003323910.016
positive regulation of programmed cell deathGO:00430682180.016
negative regulation of lymphocyte activationGO:0051250910.016
forebrain neuron developmentGO:0021884300.016
cellular macromolecule catabolic processGO:00442652060.016
muscle cell developmentGO:00550011330.016
protein localization to membraneGO:00726571080.016
mrna processingGO:0006397630.016
rna interferenceGO:001624620.016
centrosome organizationGO:0051297260.015
Mouse
positive regulation of necrotic cell deathGO:001094010.015
regulation of cell adhesionGO:00301551540.015
protein localization to plasma membraneGO:0072659570.015
regulation of androgen receptor signaling pathwayGO:006076530.015
regulation of neurotransmitter transportGO:0051588350.015
spermatid differentiationGO:00485151150.015
regulation of cellular carbohydrate metabolic processGO:0010675750.015
transforming growth factor beta1 productionGO:003290530.015
positive regulation of endocytosisGO:0045807420.015
oocyte axis specificationGO:000730920.015
Fly
regulation of protein maturationGO:1903317960.015
limb morphogenesisGO:00351081490.015
cation homeostasisGO:00550802120.015
tube formationGO:00351481400.015
Mouse
protein processingGO:00164851630.014
neurotransmitter transportGO:0006836760.014
regulation of ossificationGO:00302781120.014
glutamate receptor signaling pathwayGO:0007215350.014
regulation of meiotic cell cycleGO:0051445340.014
circadian rhythmGO:00076231140.014
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.014
striated muscle tissue developmentGO:00147062930.014
respiratory tube developmentGO:00303231670.014
positive regulation of cytokine productionGO:00018191740.014
endothelial cell developmentGO:0001885200.014
calcium ion transportGO:00068161590.014
protein maturationGO:00516041760.014
regulation of proteolysisGO:00301621640.014
negative regulation of neuron deathGO:1901215980.014
positive regulation of protein kinase activityGO:00458601440.014
regulation of vasculature developmentGO:1901342880.014
Human
stress granule disassemblyGO:003561720.013
tissue homeostasisGO:00018941150.013
muscle tissue developmentGO:00605373080.013
chemotaxisGO:00069352470.013
regulation of leukocyte proliferationGO:00706631210.013
mitotic cytokinesisGO:000028140.013
Fly
macromolecule catabolic processGO:00090572810.013
necrotic cell deathGO:0070265300.013
regulation of fat cell differentiationGO:0045598810.013
actin filament polymerizationGO:0030041440.013
gene silencingGO:0016458380.013
negative regulation of leukocyte proliferationGO:0070664460.013
positive regulation of transferase activityGO:00513471670.013
epithelial tube morphogenesisGO:00605623030.013
Mouse
positive regulation of mitotic cell cycleGO:0045931410.013
b cell activationGO:00421131610.013
respiratory system developmentGO:00605411900.013
negative regulation of protein modification processGO:00314001630.013
regulation of erk1 and erk2 cascadeGO:0070372710.013
nitrogen compound transportGO:00717052710.013
response to organic cyclic compoundGO:00140701980.013
positive regulation of rac protein signal transductionGO:003502210.013
transmembrane transportGO:00550854120.013
regulation of cell growthGO:0001558910.013
centrosome cycleGO:0007098230.013
Mouse
chromatin remodelingGO:0006338320.013
purine ribonucleoside monophosphate catabolic processGO:0009169570.012
metal ion homeostasisGO:00550651890.012
regulation of transporter activityGO:0032409570.012
camera type eye photoreceptor cell differentiationGO:0060219150.012
regulation of neural precursor cell proliferationGO:2000177700.012
negative regulation of cell activationGO:00508661110.012
regulation of transmembrane transportGO:00347621280.012
neuronal action potentialGO:0019228540.012
regulation of t cell proliferationGO:0042129920.012
photoreceptor cell differentiationGO:0046530520.012
rhythmic processGO:00485111740.012
Mouse
chromosome segregationGO:0007059480.012
neuron deathGO:00709971540.012
cellular response to abiotic stimulusGO:0071214560.012
regulation of wnt signaling pathwayGO:00301111230.012
Fly
monosaccharide metabolic processGO:00059961060.012
positive regulation of potassium ion transportGO:004326830.011
lactationGO:0007595250.011
cell matrix adhesionGO:0007160680.011
regulation of hematopoietic progenitor cell differentiationGO:1901532180.011
microtubule organizing center organizationGO:0031023280.011
Mouse
regulation of receptor mediated endocytosisGO:0048259160.011
adult behaviorGO:00305341350.011
negative regulation of cell cycleGO:00457861230.011
positive regulation of leukocyte differentiationGO:1902107860.011
chromatin modificationGO:00165681870.011
sensory perceptionGO:00076002450.011
cytoplasmic transportGO:00164822340.011
positive regulation of cell cycleGO:0045787920.011
Mouse
regulation of stress activated mapk cascadeGO:0032872690.011
positive regulation of growthGO:00459271040.011
protein modification by small protein conjugationGO:00324461870.011
multicellular organismal signalingGO:0035637910.011
ribonucleoprotein complex disassemblyGO:003298830.011
response to radiationGO:00093141650.011
asymmetric stem cell divisionGO:009872230.011
positive regulation of rab gtpase activityGO:003285170.011
actin filament organizationGO:00070151130.011
Fly
detection of external stimulusGO:0009581610.011
stress activated mapk cascadeGO:0051403800.011
inorganic cation transmembrane transportGO:00986622070.011
stem cell developmentGO:00488642190.011
spermatid developmentGO:00072861080.011
regulation of smoothened signaling pathwayGO:0008589580.011
negative regulation of peptidase activityGO:0010466460.011
b cell proliferationGO:0042100530.011
purine nucleoside monophosphate catabolic processGO:0009128580.011
skeletal system morphogenesisGO:00487052030.011
leukocyte apoptotic processGO:0071887710.011
synaptic transmission gabaergicGO:0051932190.010
bone developmentGO:00603481200.010
regionalizationGO:00030023370.010
morphogenesis of a branching epitheliumGO:00611381930.010
positive regulation of ras protein signal transductionGO:0046579130.010
negative regulation of immune system processGO:00026832090.010
regulation of glucose metabolic processGO:0010906600.010
sister chromatid segregationGO:0000819200.010
carbohydrate homeostasisGO:00335001280.010
positive regulation of neuron projection developmentGO:0010976790.010
embryonic limb morphogenesisGO:00303261260.010
regulation of embryonic developmentGO:0045995710.010
maternal determination of anterior posterior axis embryoGO:000835820.010
regulation of b cell proliferationGO:0030888390.010
cellular divalent inorganic cation homeostasisGO:00725031270.010
digestive system developmentGO:00551232000.010
Fly

Rock1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.032
disease of cellular proliferationDOID:1456600.032
kidney diseaseDOID:55700.019
disease of anatomical entityDOID:700.019
urinary system diseaseDOID:1800.019
nephritisDOID:1095200.019
nervous system diseaseDOID:86300.013
sensory system diseaseDOID:005015500.013