| negative regulation of cellular protein metabolic process | GO:0032269 | 247 | 0.131 | |
| rna processing | GO:0006396 | 105 | 0.120 | |
| gonad development | GO:0008406 | 141 | 0.100 | Worm |
| translation | GO:0006412 | 93 | 0.084 | |
| rna splicing | GO:0008380 | 54 | 0.083 | |
| germ cell development | GO:0007281 | 185 | 0.074 | Worm Fly |
| regulation of rna splicing | GO:0043484 | 37 | 0.067 | |
| cellular amino acid metabolic process | GO:0006520 | 103 | 0.066 | |
| protein ubiquitination | GO:0016567 | 171 | 0.058 | |
| organelle fission | GO:0048285 | 170 | 0.054 | Yeast Worm |
| chromosome organization involved in meiosis | GO:0070192 | 39 | 0.045 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 155 | 0.045 | |
| epithelial cell development | GO:0002064 | 159 | 0.044 | |
| spermatogenesis | GO:0007283 | 284 | 0.043 | |
| ribonucleoprotein complex localization | GO:0071166 | 1 | 0.043 | |
| meiotic nuclear division | GO:0007126 | 115 | 0.043 | Worm |
| mrna metabolic process | GO:0016071 | 84 | 0.041 | |
| regulation of mrna splicing via spliceosome | GO:0048024 | 32 | 0.040 | |
| chromatin modification | GO:0016568 | 187 | 0.039 | Human |
| leukocyte differentiation | GO:0002521 | 342 | 0.037 | |
| regulation of kinase activity | GO:0043549 | 249 | 0.037 | |
| oocyte construction | GO:0007308 | 2 | 0.036 | |
| oocyte axis specification | GO:0007309 | 2 | 0.036 | |
| cation transport | GO:0006812 | 399 | 0.035 | |
| development of primary sexual characteristics | GO:0045137 | 143 | 0.035 | Worm |
| dna metabolic process | GO:0006259 | 303 | 0.035 | |
| appendage development | GO:0048736 | 166 | 0.035 | |
| cellular ketone metabolic process | GO:0042180 | 84 | 0.034 | |
| regulation of response to wounding | GO:1903034 | 189 | 0.034 | |
| protein modification by small protein conjugation | GO:0032446 | 187 | 0.033 | |
| mrna transport | GO:0051028 | 13 | 0.033 | |
| regulation of proteolysis | GO:0030162 | 164 | 0.033 | |
| regulation of circadian rhythm | GO:0042752 | 58 | 0.033 | |
| cellular macromolecule catabolic process | GO:0044265 | 206 | 0.032 | |
| oxidation reduction process | GO:0055114 | 342 | 0.032 | |
| carbohydrate derivative biosynthetic process | GO:1901137 | 183 | 0.032 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 66 | 0.031 | |
| negative regulation of phosphorylation | GO:0042326 | 166 | 0.031 | |
| nuclear division | GO:0000280 | 158 | 0.030 | Yeast Worm |
| oogenesis | GO:0048477 | 56 | 0.030 | Worm Fly |
| positive regulation of macroautophagy | GO:0016239 | 3 | 0.030 | |
| limb development | GO:0060173 | 166 | 0.030 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 133 | 0.030 | |
| amine metabolic process | GO:0009308 | 45 | 0.030 | |
| chromatin organization | GO:0006325 | 206 | 0.029 | Human Yeast |
| negative regulation of molecular function | GO:0044092 | 258 | 0.029 | |
| rna interference | GO:0016246 | 2 | 0.028 | |
| rna splicing via transesterification reactions with bulged adenosine as nucleophile | GO:0000377 | 43 | 0.028 | |
| male gamete generation | GO:0048232 | 285 | 0.028 | |
| rhythmic process | GO:0048511 | 174 | 0.028 | Human |
| regulation of cellular amino acid metabolic process | GO:0006521 | 5 | 0.028 | |
| cellular amine metabolic process | GO:0044106 | 44 | 0.028 | |
| mrna processing | GO:0006397 | 63 | 0.027 | |
| cellular response to oxidative stress | GO:0034599 | 76 | 0.027 | |
| t cell activation | GO:0042110 | 289 | 0.027 | |
| regulation of organelle organization | GO:0033043 | 289 | 0.027 | |
| cardiac muscle cell contraction | GO:0086003 | 7 | 0.026 | |
| cajal body organization | GO:0030576 | 1 | 0.026 | |
| chromosome segregation | GO:0007059 | 48 | 0.026 | Yeast Worm Fly |
| regulation of cell cycle | GO:0051726 | 281 | 0.024 | |
| regulation of translation | GO:0006417 | 71 | 0.024 | |
| organelle localization | GO:0051640 | 179 | 0.024 | Yeast |
| glucose homeostasis | GO:0042593 | 128 | 0.024 | |
| transdifferentiation | GO:0060290 | 1 | 0.023 | |
| covalent chromatin modification | GO:0016569 | 163 | 0.023 | |
| ear development | GO:0043583 | 200 | 0.023 | |
| organonitrogen compound biosynthetic process | GO:1901566 | 192 | 0.023 | |
| sensory perception | GO:0007600 | 245 | 0.023 | |
| cellular homeostasis | GO:0019725 | 240 | 0.023 | |
| regulation of proteolysis involved in cellular protein catabolic process | GO:1903050 | 56 | 0.023 | |
| skeletal system development | GO:0001501 | 356 | 0.023 | |
| regulation of mrna processing | GO:0050684 | 41 | 0.023 | |
| multicellular organism growth | GO:0035264 | 161 | 0.023 | |
| macromolecule catabolic process | GO:0009057 | 281 | 0.023 | |
| response to oxidative stress | GO:0006979 | 123 | 0.022 | |
| compound eye development | GO:0048749 | 1 | 0.022 | |
| regulation of protein kinase activity | GO:0045859 | 232 | 0.022 | |
| rna splicing via transesterification reactions | GO:0000375 | 43 | 0.022 | |
| regulation of protein localization | GO:0032880 | 231 | 0.021 | |
| cognition | GO:0050890 | 149 | 0.021 | |
| negative regulation of protein metabolic process | GO:0051248 | 282 | 0.021 | |
| heterocycle catabolic process | GO:0046700 | 280 | 0.021 | |
| alternative mrna splicing via spliceosome | GO:0000380 | 12 | 0.021 | |
| pole plasm assembly | GO:0007315 | 2 | 0.021 | |
| appendage morphogenesis | GO:0035107 | 149 | 0.021 | |
| muscle cell differentiation | GO:0042692 | 261 | 0.021 | |
| regulation of transferase activity | GO:0051338 | 263 | 0.020 | |
| negative regulation of phosphate metabolic process | GO:0045936 | 184 | 0.020 | |
| embryonic skeletal system development | GO:0048706 | 120 | 0.020 | |
| response to radiation | GO:0009314 | 165 | 0.020 | |
| meiosis i | GO:0007127 | 60 | 0.020 | |
| segmentation | GO:0035282 | 93 | 0.020 | |
| neuron apoptotic process | GO:0051402 | 142 | 0.019 | |
| nitrogen compound transport | GO:0071705 | 271 | 0.019 | |
| regulation of chromatin silencing | GO:0031935 | 2 | 0.019 | |
| transmembrane transport | GO:0055085 | 412 | 0.019 | |
| circadian rhythm | GO:0007623 | 114 | 0.019 | Human |
| regulation of protein processing | GO:0070613 | 96 | 0.019 | |
| mrna splicing via spliceosome | GO:0000398 | 43 | 0.019 | |
| locomotory behavior | GO:0007626 | 195 | 0.019 | |
| negative regulation of immune system process | GO:0002683 | 209 | 0.018 | |
| heart morphogenesis | GO:0003007 | 178 | 0.018 | |
| regulation of cell motility | GO:2000145 | 236 | 0.018 | |
| regulation of neuron differentiation | GO:0045664 | 281 | 0.018 | |
| nuclear export | GO:0051168 | 34 | 0.018 | |
| spermatid differentiation | GO:0048515 | 115 | 0.018 | |
| glycoprotein biosynthetic process | GO:0009101 | 89 | 0.018 | |
| glycoprotein metabolic process | GO:0009100 | 116 | 0.018 | |
| nuclear transport | GO:0051169 | 139 | 0.018 | |
| immune effector process | GO:0002252 | 321 | 0.018 | |
| regulation of system process | GO:0044057 | 200 | 0.018 | |
| carbohydrate homeostasis | GO:0033500 | 128 | 0.018 | |
| cellular chemical homeostasis | GO:0055082 | 215 | 0.018 | |
| cell type specific apoptotic process | GO:0097285 | 268 | 0.018 | |
| microtubule based process | GO:0007017 | 236 | 0.018 | |
| regulation of cellular amine metabolic process | GO:0033238 | 20 | 0.018 | |
| regulation of transcription by chromatin organization | GO:0034401 | 0 | 0.018 | |
| regulation of cell projection organization | GO:0031344 | 206 | 0.017 | |
| negative regulation of lymphocyte activation | GO:0051250 | 91 | 0.017 | |
| meiotic cell cycle | GO:0051321 | 122 | 0.017 | Worm |
| regulation of nuclear division | GO:0051783 | 56 | 0.017 | |
| carboxylic acid biosynthetic process | GO:0046394 | 86 | 0.017 | |
| regulation of protein catabolic process | GO:0042176 | 108 | 0.017 | |
| muscle tissue development | GO:0060537 | 308 | 0.017 | |
| protein modification by small protein conjugation or removal | GO:0070647 | 207 | 0.017 | |
| negative regulation of cellular component organization | GO:0051129 | 194 | 0.017 | |
| protein maturation | GO:0051604 | 176 | 0.017 | |
| aromatic compound catabolic process | GO:0019439 | 286 | 0.017 | |
| spermatid development | GO:0007286 | 108 | 0.017 | |
| regulation of t cell activation | GO:0050863 | 170 | 0.017 | |
| neural precursor cell proliferation | GO:0061351 | 121 | 0.017 | |
| dendrite development | GO:0016358 | 115 | 0.017 | |
| regulation of protein maturation | GO:1903317 | 96 | 0.016 | |
| purine ribonucleotide catabolic process | GO:0009154 | 208 | 0.016 | |
| negative regulation of kinase activity | GO:0033673 | 81 | 0.016 | |
| protein dna complex subunit organization | GO:0071824 | 28 | 0.016 | |
| regulation of cell division | GO:0051302 | 76 | 0.016 | |
| nucleoside metabolic process | GO:0009116 | 246 | 0.016 | |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 147 | 0.016 | |
| fat cell differentiation | GO:0045444 | 160 | 0.016 | |
| cation transmembrane transport | GO:0098655 | 266 | 0.016 | |
| mitotic cell cycle | GO:0000278 | 195 | 0.016 | Yeast |
| actin mediated cell contraction | GO:0070252 | 15 | 0.016 | |
| establishment of rna localization | GO:0051236 | 18 | 0.016 | |
| positive regulation of mapk cascade | GO:0043410 | 170 | 0.016 | |
| regulation of binding | GO:0051098 | 111 | 0.016 | |
| cell fate commitment | GO:0045165 | 210 | 0.016 | |
| positive regulation of organelle organization | GO:0010638 | 128 | 0.016 | |
| actin cytoskeleton organization | GO:0030036 | 220 | 0.015 | |
| cell division | GO:0051301 | 120 | 0.015 | |
| intracellular mrna localization | GO:0008298 | 4 | 0.015 | |
| carbohydrate metabolic process | GO:0005975 | 230 | 0.015 | |
| regulation of protein serine threonine kinase activity | GO:0071900 | 157 | 0.015 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 5 | 0.015 | |
| modification dependent protein catabolic process | GO:0019941 | 133 | 0.015 | |
| cellular nitrogen compound catabolic process | GO:0044270 | 280 | 0.015 | |
| microtubule cytoskeleton organization | GO:0000226 | 157 | 0.015 | |
| neural tube development | GO:0021915 | 160 | 0.015 | |
| muscle contraction | GO:0006936 | 101 | 0.015 | |
| stem cell fate specification | GO:0048866 | 3 | 0.015 | |
| negative regulation of cellular amine metabolic process | GO:0033239 | 1 | 0.015 | |
| ribonucleoprotein complex subunit organization | GO:0071826 | 28 | 0.015 | |
| morphogenesis of embryonic epithelium | GO:0016331 | 159 | 0.015 | |
| neural tube closure | GO:0001843 | 90 | 0.014 | |
| inter male aggressive behavior | GO:0002121 | 3 | 0.014 | |
| cellular lipid metabolic process | GO:0044255 | 323 | 0.014 | |
| lipid biosynthetic process | GO:0008610 | 179 | 0.014 | |
| rna transport | GO:0050658 | 18 | 0.014 | |
| organelle assembly | GO:0070925 | 177 | 0.014 | |
| dna integrity checkpoint | GO:0031570 | 28 | 0.014 | |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 88 | 0.014 | |
| female sex determination | GO:0030237 | 1 | 0.014 | |
| sulfur compound metabolic process | GO:0006790 | 100 | 0.014 | |
| positive regulation of proteolysis | GO:0045862 | 85 | 0.014 | |
| small molecule biosynthetic process | GO:0044283 | 132 | 0.014 | |
| endothelial cell morphogenesis | GO:0001886 | 9 | 0.014 | |
| cellular response to insulin stimulus | GO:0032869 | 78 | 0.014 | |
| regulation of cellular response to stress | GO:0080135 | 159 | 0.014 | |
| ossification | GO:0001503 | 216 | 0.014 | |
| digestive tract morphogenesis | GO:0048546 | 147 | 0.014 | |
| maintenance of location | GO:0051235 | 89 | 0.014 | |
| heart process | GO:0003015 | 94 | 0.014 | |
| monocarboxylic acid metabolic process | GO:0032787 | 191 | 0.014 | |
| regulation of cell migration | GO:0030334 | 219 | 0.014 | |
| sensory perception of light stimulus | GO:0050953 | 54 | 0.014 | |
| negative regulation of transferase activity | GO:0051348 | 85 | 0.014 | |
| endothelium development | GO:0003158 | 45 | 0.014 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 352 | 0.013 | |
| embryonic appendage morphogenesis | GO:0035113 | 126 | 0.013 | |
| negative regulation of intracellular signal transduction | GO:1902532 | 167 | 0.013 | |
| actin filament based movement | GO:0030048 | 23 | 0.013 | |
| organic acid biosynthetic process | GO:0016053 | 86 | 0.013 | |
| establishment or maintenance of cytoskeleton polarity | GO:0030952 | 2 | 0.013 | |
| epithelial cell morphogenesis | GO:0003382 | 41 | 0.013 | |
| protein processing | GO:0016485 | 163 | 0.013 | |
| regulation of ion transport | GO:0043269 | 215 | 0.013 | |
| neuron death | GO:0070997 | 154 | 0.013 | |
| tube closure | GO:0060606 | 91 | 0.013 | |
| angiogenesis | GO:0001525 | 201 | 0.013 | |
| epidermis development | GO:0008544 | 187 | 0.013 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.013 | |
| myosin filament organization | GO:0031033 | 3 | 0.013 | |
| inorganic ion transmembrane transport | GO:0098660 | 234 | 0.013 | |
| central nervous system neuron differentiation | GO:0021953 | 162 | 0.013 | |
| learning or memory | GO:0007611 | 148 | 0.013 | |
| regulation of angiogenesis | GO:0045765 | 81 | 0.012 | |
| striated muscle myosin thick filament assembly | GO:0071688 | 1 | 0.012 | |
| activation of immune response | GO:0002253 | 138 | 0.012 | |
| establishment of organelle localization | GO:0051656 | 122 | 0.012 | Yeast |
| jnk cascade | GO:0007254 | 72 | 0.012 | |
| genitalia development | GO:0048806 | 37 | 0.012 | |
| regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032434 | 40 | 0.012 | |
| extracellular structure organization | GO:0043062 | 148 | 0.012 | |
| carbohydrate biosynthetic process | GO:0016051 | 74 | 0.012 | |
| jak stat cascade | GO:0007259 | 42 | 0.012 | |
| endothelial cell development | GO:0001885 | 20 | 0.012 | |
| blood circulation | GO:0008015 | 195 | 0.012 | |
| striated muscle tissue development | GO:0014706 | 293 | 0.012 | |
| intracellular steroid hormone receptor signaling pathway | GO:0030518 | 29 | 0.012 | |
| digestive tract development | GO:0048565 | 190 | 0.012 | |
| ribose phosphate metabolic process | GO:0019693 | 291 | 0.012 | |
| learning | GO:0007612 | 98 | 0.012 | |
| chromatin silencing at rdna | GO:0000183 | 3 | 0.012 | Yeast |
| negative regulation of protein maturation | GO:1903318 | 79 | 0.012 | |
| digestive system development | GO:0055123 | 200 | 0.012 | |
| response to peptide | GO:1901652 | 136 | 0.012 | |
| organelle disassembly | GO:1903008 | 2 | 0.012 | |
| t cell differentiation | GO:0030217 | 174 | 0.012 | |
| negative regulation of cell activation | GO:0050866 | 111 | 0.012 | |
| respiratory system development | GO:0060541 | 190 | 0.012 | |
| regulation of proteasomal protein catabolic process | GO:0061136 | 46 | 0.012 | |
| epithelial tube morphogenesis | GO:0060562 | 303 | 0.012 | |
| mesoderm development | GO:0007498 | 100 | 0.012 | |
| regulation of meiotic cell cycle | GO:0051445 | 34 | 0.012 | |
| regulation of rna export from nucleus | GO:0046831 | 4 | 0.012 | |
| glycosyl compound metabolic process | GO:1901657 | 246 | 0.011 | |
| cell adhesion | GO:0007155 | 329 | 0.011 | |
| positive regulation of nervous system development | GO:0051962 | 221 | 0.011 | |
| striated muscle contraction | GO:0006941 | 45 | 0.011 | |
| cellular response to starvation | GO:0009267 | 57 | 0.011 | |
| carbohydrate derivative catabolic process | GO:1901136 | 231 | 0.011 | |
| positive regulation of cell death | GO:0010942 | 224 | 0.011 | |
| oocyte anterior posterior axis specification | GO:0007314 | 2 | 0.011 | |
| regulation of cell activation | GO:0050865 | 289 | 0.011 | |
| nucleocytoplasmic transport | GO:0006913 | 139 | 0.011 | |
| lipid localization | GO:0010876 | 126 | 0.011 | |
| habituation | GO:0046959 | 3 | 0.011 | |
| cellular response to abiotic stimulus | GO:0071214 | 56 | 0.011 | |
| negative regulation of ossification | GO:0030279 | 49 | 0.011 | |
| endocytosis | GO:0006897 | 168 | 0.011 | Worm |
| b cell activation | GO:0042113 | 161 | 0.011 | |
| stem cell maintenance | GO:0019827 | 130 | 0.011 | |
| transmembrane receptor protein tyrosine kinase signaling pathway | GO:0007169 | 247 | 0.011 | |
| negative regulation of proteolysis | GO:0045861 | 74 | 0.011 | |
| inflammatory response | GO:0006954 | 244 | 0.011 | |
| nucleoside phosphate metabolic process | GO:0006753 | 338 | 0.011 | |
| regulation of nucleoside metabolic process | GO:0009118 | 130 | 0.011 | |
| cell maturation | GO:0048469 | 127 | 0.011 | |
| alpha amino acid metabolic process | GO:1901605 | 59 | 0.011 | |
| negative regulation of protein modification process | GO:0031400 | 163 | 0.011 | |
| intracellular protein transport | GO:0006886 | 204 | 0.011 | |
| regulation of hormone levels | GO:0010817 | 211 | 0.011 | |
| circadian regulation of gene expression | GO:0032922 | 48 | 0.011 | Human |
| coenzyme biosynthetic process | GO:0009108 | 23 | 0.011 | |
| epithelial tube formation | GO:0072175 | 130 | 0.011 | |
| lymphocyte differentiation | GO:0030098 | 242 | 0.011 | |
| macromolecule deacylation | GO:0098732 | 37 | 0.011 | |
| fatty acid metabolic process | GO:0006631 | 121 | 0.011 | |
| cellular response to cytokine stimulus | GO:0071345 | 189 | 0.011 | |
| negative regulation of mapk cascade | GO:0043409 | 65 | 0.011 | |
| rna localization | GO:0006403 | 23 | 0.011 | |
| tube formation | GO:0035148 | 140 | 0.011 | |
| purine ribonucleoside triphosphate catabolic process | GO:0009207 | 199 | 0.011 | |
| purine nucleoside triphosphate metabolic process | GO:0009144 | 226 | 0.010 | |
| dephosphorylation | GO:0016311 | 129 | 0.010 | |
| blood vessel morphogenesis | GO:0048514 | 285 | 0.010 | |
| respiratory tube development | GO:0030323 | 167 | 0.010 | |
| purine ribonucleoside catabolic process | GO:0046130 | 205 | 0.010 | |
| inorganic cation transmembrane transport | GO:0098662 | 207 | 0.010 | |
| regulation of cellular catabolic process | GO:0031329 | 242 | 0.010 | |
| regulation of protein complex assembly | GO:0043254 | 83 | 0.010 | |
| rho protein signal transduction | GO:0007266 | 32 | 0.010 | |
| mapk cascade | GO:0000165 | 281 | 0.010 | |
| forebrain development | GO:0030900 | 302 | 0.010 | |
| peptidyl amino acid modification | GO:0018193 | 336 | 0.010 | |
| mitotic nuclear division | GO:0007067 | 48 | 0.010 | Yeast |
| ribonucleoprotein complex disassembly | GO:0032988 | 3 | 0.010 | |
| apoptotic signaling pathway | GO:0097190 | 306 | 0.010 | |
| cellular carbohydrate metabolic process | GO:0044262 | 119 | 0.010 | |
| cellular response to organonitrogen compound | GO:0071417 | 145 | 0.010 | |
| histone deubiquitination | GO:0016578 | 2 | 0.010 | |
| negative regulation of cell development | GO:0010721 | 169 | 0.010 | |
| placenta development | GO:0001890 | 140 | 0.010 | |
| regulation of ossification | GO:0030278 | 112 | 0.010 | |
| negative regulation of dna replication | GO:0008156 | 4 | 0.010 | |
| posttranscriptional gene silencing by rna | GO:0035194 | 10 | 0.010 | |
| protein localization to nucleus | GO:0034504 | 121 | 0.010 | |
| circulatory system process | GO:0003013 | 197 | 0.010 | |
| endothelial cell differentiation | GO:0045446 | 41 | 0.010 | |
| nucleotide metabolic process | GO:0009117 | 332 | 0.010 | |
| adult behavior | GO:0030534 | 135 | 0.010 | |
| cell junction assembly | GO:0034329 | 52 | 0.010 | |
