Mus musculus

35 known processes

Top1

topoisomerase (DNA) I

(Aliases: D130064I21Rik,Top-1,AI467334)

Top1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of cellular protein metabolic processGO:00322692470.131
rna processingGO:00063961050.120
gonad developmentGO:00084061410.100
Worm
translationGO:0006412930.084
rna splicingGO:0008380540.083
germ cell developmentGO:00072811850.074
Worm Fly
regulation of rna splicingGO:0043484370.067
cellular amino acid metabolic processGO:00065201030.066
protein ubiquitinationGO:00165671710.058
organelle fissionGO:00482851700.054
Yeast Worm
chromosome organization involved in meiosisGO:0070192390.045
posttranscriptional regulation of gene expressionGO:00106081550.045
epithelial cell developmentGO:00020641590.044
spermatogenesisGO:00072832840.043
ribonucleoprotein complex localizationGO:007116610.043
meiotic nuclear divisionGO:00071261150.043
Worm
mrna metabolic processGO:0016071840.041
regulation of mrna splicing via spliceosomeGO:0048024320.040
chromatin modificationGO:00165681870.039
Human
leukocyte differentiationGO:00025213420.037
regulation of kinase activityGO:00435492490.037
oocyte constructionGO:000730820.036
oocyte axis specificationGO:000730920.036
cation transportGO:00068123990.035
development of primary sexual characteristicsGO:00451371430.035
Worm
dna metabolic processGO:00062593030.035
appendage developmentGO:00487361660.035
cellular ketone metabolic processGO:0042180840.034
regulation of response to woundingGO:19030341890.034
protein modification by small protein conjugationGO:00324461870.033
mrna transportGO:0051028130.033
regulation of proteolysisGO:00301621640.033
regulation of circadian rhythmGO:0042752580.033
cellular macromolecule catabolic processGO:00442652060.032
oxidation reduction processGO:00551143420.032
carbohydrate derivative biosynthetic processGO:19011371830.032
regulation of cellular ketone metabolic processGO:0010565660.031
negative regulation of phosphorylationGO:00423261660.031
nuclear divisionGO:00002801580.030
Yeast Worm
oogenesisGO:0048477560.030
Worm Fly
positive regulation of macroautophagyGO:001623930.030
limb developmentGO:00601731660.030
modification dependent macromolecule catabolic processGO:00436321330.030
amine metabolic processGO:0009308450.030
chromatin organizationGO:00063252060.029
Human Yeast
negative regulation of molecular functionGO:00440922580.029
rna interferenceGO:001624620.028
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377430.028
male gamete generationGO:00482322850.028
rhythmic processGO:00485111740.028
Human
regulation of cellular amino acid metabolic processGO:000652150.028
cellular amine metabolic processGO:0044106440.028
mrna processingGO:0006397630.027
cellular response to oxidative stressGO:0034599760.027
t cell activationGO:00421102890.027
regulation of organelle organizationGO:00330432890.027
cardiac muscle cell contractionGO:008600370.026
cajal body organizationGO:003057610.026
chromosome segregationGO:0007059480.026
Yeast Worm Fly
regulation of cell cycleGO:00517262810.024
regulation of translationGO:0006417710.024
organelle localizationGO:00516401790.024
Yeast
glucose homeostasisGO:00425931280.024
transdifferentiationGO:006029010.023
covalent chromatin modificationGO:00165691630.023
ear developmentGO:00435832000.023
organonitrogen compound biosynthetic processGO:19015661920.023
sensory perceptionGO:00076002450.023
cellular homeostasisGO:00197252400.023
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.023
skeletal system developmentGO:00015013560.023
regulation of mrna processingGO:0050684410.023
multicellular organism growthGO:00352641610.023
macromolecule catabolic processGO:00090572810.023
response to oxidative stressGO:00069791230.022
compound eye developmentGO:004874910.022
regulation of protein kinase activityGO:00458592320.022
rna splicing via transesterification reactionsGO:0000375430.022
regulation of protein localizationGO:00328802310.021
cognitionGO:00508901490.021
negative regulation of protein metabolic processGO:00512482820.021
heterocycle catabolic processGO:00467002800.021
alternative mrna splicing via spliceosomeGO:0000380120.021
pole plasm assemblyGO:000731520.021
appendage morphogenesisGO:00351071490.021
muscle cell differentiationGO:00426922610.021
regulation of transferase activityGO:00513382630.020
negative regulation of phosphate metabolic processGO:00459361840.020
embryonic skeletal system developmentGO:00487061200.020
response to radiationGO:00093141650.020
meiosis iGO:0007127600.020
segmentationGO:0035282930.020
neuron apoptotic processGO:00514021420.019
nitrogen compound transportGO:00717052710.019
regulation of chromatin silencingGO:003193520.019
transmembrane transportGO:00550854120.019
circadian rhythmGO:00076231140.019
Human
regulation of protein processingGO:0070613960.019
mrna splicing via spliceosomeGO:0000398430.019
locomotory behaviorGO:00076261950.019
negative regulation of immune system processGO:00026832090.018
heart morphogenesisGO:00030071780.018
regulation of cell motilityGO:20001452360.018
regulation of neuron differentiationGO:00456642810.018
nuclear exportGO:0051168340.018
spermatid differentiationGO:00485151150.018
glycoprotein biosynthetic processGO:0009101890.018
glycoprotein metabolic processGO:00091001160.018
nuclear transportGO:00511691390.018
immune effector processGO:00022523210.018
regulation of system processGO:00440572000.018
carbohydrate homeostasisGO:00335001280.018
cellular chemical homeostasisGO:00550822150.018
cell type specific apoptotic processGO:00972852680.018
microtubule based processGO:00070172360.018
regulation of cellular amine metabolic processGO:0033238200.018
regulation of transcription by chromatin organizationGO:003440100.018
regulation of cell projection organizationGO:00313442060.017
negative regulation of lymphocyte activationGO:0051250910.017
meiotic cell cycleGO:00513211220.017
Worm
regulation of nuclear divisionGO:0051783560.017
carboxylic acid biosynthetic processGO:0046394860.017
regulation of protein catabolic processGO:00421761080.017
muscle tissue developmentGO:00605373080.017
protein modification by small protein conjugation or removalGO:00706472070.017
negative regulation of cellular component organizationGO:00511291940.017
protein maturationGO:00516041760.017
aromatic compound catabolic processGO:00194392860.017
spermatid developmentGO:00072861080.017
regulation of t cell activationGO:00508631700.017
neural precursor cell proliferationGO:00613511210.017
dendrite developmentGO:00163581150.017
regulation of protein maturationGO:1903317960.016
purine ribonucleotide catabolic processGO:00091542080.016
negative regulation of kinase activityGO:0033673810.016
protein dna complex subunit organizationGO:0071824280.016
regulation of cell divisionGO:0051302760.016
nucleoside metabolic processGO:00091162460.016
proteolysis involved in cellular protein catabolic processGO:00516031470.016
fat cell differentiationGO:00454441600.016
cation transmembrane transportGO:00986552660.016
mitotic cell cycleGO:00002781950.016
Yeast
actin mediated cell contractionGO:0070252150.016
establishment of rna localizationGO:0051236180.016
positive regulation of mapk cascadeGO:00434101700.016
regulation of bindingGO:00510981110.016
cell fate commitmentGO:00451652100.016
positive regulation of organelle organizationGO:00106381280.016
actin cytoskeleton organizationGO:00300362200.015
cell divisionGO:00513011200.015
intracellular mrna localizationGO:000829840.015
carbohydrate metabolic processGO:00059752300.015
regulation of protein serine threonine kinase activityGO:00719001570.015
positive regulation of cellular amine metabolic processGO:003324050.015
modification dependent protein catabolic processGO:00199411330.015
cellular nitrogen compound catabolic processGO:00442702800.015
microtubule cytoskeleton organizationGO:00002261570.015
neural tube developmentGO:00219151600.015
muscle contractionGO:00069361010.015
stem cell fate specificationGO:004886630.015
negative regulation of cellular amine metabolic processGO:003323910.015
ribonucleoprotein complex subunit organizationGO:0071826280.015
morphogenesis of embryonic epitheliumGO:00163311590.015
neural tube closureGO:0001843900.014
inter male aggressive behaviorGO:000212130.014
cellular lipid metabolic processGO:00442553230.014
lipid biosynthetic processGO:00086101790.014
rna transportGO:0050658180.014
organelle assemblyGO:00709251770.014
dna integrity checkpointGO:0031570280.014
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.014
female sex determinationGO:003023710.014
sulfur compound metabolic processGO:00067901000.014
positive regulation of proteolysisGO:0045862850.014
small molecule biosynthetic processGO:00442831320.014
endothelial cell morphogenesisGO:000188690.014
cellular response to insulin stimulusGO:0032869780.014
regulation of cellular response to stressGO:00801351590.014
ossificationGO:00015032160.014
digestive tract morphogenesisGO:00485461470.014
maintenance of locationGO:0051235890.014
heart processGO:0003015940.014
monocarboxylic acid metabolic processGO:00327871910.014
regulation of cell migrationGO:00303342190.014
sensory perception of light stimulusGO:0050953540.014
negative regulation of transferase activityGO:0051348850.014
endothelium developmentGO:0003158450.014
nucleobase containing small molecule metabolic processGO:00550863520.013
embryonic appendage morphogenesisGO:00351131260.013
negative regulation of intracellular signal transductionGO:19025321670.013
actin filament based movementGO:0030048230.013
organic acid biosynthetic processGO:0016053860.013
establishment or maintenance of cytoskeleton polarityGO:003095220.013
epithelial cell morphogenesisGO:0003382410.013
protein processingGO:00164851630.013
regulation of ion transportGO:00432692150.013
neuron deathGO:00709971540.013
tube closureGO:0060606910.013
angiogenesisGO:00015252010.013
epidermis developmentGO:00085441870.013
positive regulation of cellular amino acid metabolic processGO:004576430.013
myosin filament organizationGO:003103330.013
inorganic ion transmembrane transportGO:00986602340.013
central nervous system neuron differentiationGO:00219531620.013
learning or memoryGO:00076111480.013
regulation of angiogenesisGO:0045765810.012
striated muscle myosin thick filament assemblyGO:007168810.012
activation of immune responseGO:00022531380.012
establishment of organelle localizationGO:00516561220.012
Yeast
jnk cascadeGO:0007254720.012
genitalia developmentGO:0048806370.012
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.012
extracellular structure organizationGO:00430621480.012
carbohydrate biosynthetic processGO:0016051740.012
jak stat cascadeGO:0007259420.012
endothelial cell developmentGO:0001885200.012
blood circulationGO:00080151950.012
striated muscle tissue developmentGO:00147062930.012
intracellular steroid hormone receptor signaling pathwayGO:0030518290.012
digestive tract developmentGO:00485651900.012
ribose phosphate metabolic processGO:00196932910.012
learningGO:0007612980.012
chromatin silencing at rdnaGO:000018330.012
Yeast
negative regulation of protein maturationGO:1903318790.012
digestive system developmentGO:00551232000.012
response to peptideGO:19016521360.012
organelle disassemblyGO:190300820.012
t cell differentiationGO:00302171740.012
negative regulation of cell activationGO:00508661110.012
respiratory system developmentGO:00605411900.012
regulation of proteasomal protein catabolic processGO:0061136460.012
epithelial tube morphogenesisGO:00605623030.012
mesoderm developmentGO:00074981000.012
regulation of meiotic cell cycleGO:0051445340.012
regulation of rna export from nucleusGO:004683140.012
glycosyl compound metabolic processGO:19016572460.011
cell adhesionGO:00071553290.011
positive regulation of nervous system developmentGO:00519622210.011
striated muscle contractionGO:0006941450.011
cellular response to starvationGO:0009267570.011
carbohydrate derivative catabolic processGO:19011362310.011
positive regulation of cell deathGO:00109422240.011
oocyte anterior posterior axis specificationGO:000731420.011
regulation of cell activationGO:00508652890.011
nucleocytoplasmic transportGO:00069131390.011
lipid localizationGO:00108761260.011
habituationGO:004695930.011
cellular response to abiotic stimulusGO:0071214560.011
negative regulation of ossificationGO:0030279490.011
endocytosisGO:00068971680.011
Worm
b cell activationGO:00421131610.011
stem cell maintenanceGO:00198271300.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.011
negative regulation of proteolysisGO:0045861740.011
inflammatory responseGO:00069542440.011
nucleoside phosphate metabolic processGO:00067533380.011
regulation of nucleoside metabolic processGO:00091181300.011
cell maturationGO:00484691270.011
alpha amino acid metabolic processGO:1901605590.011
negative regulation of protein modification processGO:00314001630.011
intracellular protein transportGO:00068862040.011
regulation of hormone levelsGO:00108172110.011
circadian regulation of gene expressionGO:0032922480.011
Human
coenzyme biosynthetic processGO:0009108230.011
epithelial tube formationGO:00721751300.011
lymphocyte differentiationGO:00300982420.011
macromolecule deacylationGO:0098732370.011
fatty acid metabolic processGO:00066311210.011
cellular response to cytokine stimulusGO:00713451890.011
negative regulation of mapk cascadeGO:0043409650.011
rna localizationGO:0006403230.011
tube formationGO:00351481400.011
purine ribonucleoside triphosphate catabolic processGO:00092071990.011
purine nucleoside triphosphate metabolic processGO:00091442260.010
dephosphorylationGO:00163111290.010
blood vessel morphogenesisGO:00485142850.010
respiratory tube developmentGO:00303231670.010
purine ribonucleoside catabolic processGO:00461302050.010
inorganic cation transmembrane transportGO:00986622070.010
regulation of cellular catabolic processGO:00313292420.010
regulation of protein complex assemblyGO:0043254830.010
rho protein signal transductionGO:0007266320.010
mapk cascadeGO:00001652810.010
forebrain developmentGO:00309003020.010
peptidyl amino acid modificationGO:00181933360.010
mitotic nuclear divisionGO:0007067480.010
Yeast
ribonucleoprotein complex disassemblyGO:003298830.010
apoptotic signaling pathwayGO:00971903060.010
cellular carbohydrate metabolic processGO:00442621190.010
cellular response to organonitrogen compoundGO:00714171450.010
histone deubiquitinationGO:001657820.010
negative regulation of cell developmentGO:00107211690.010
placenta developmentGO:00018901400.010
regulation of ossificationGO:00302781120.010
negative regulation of dna replicationGO:000815640.010
posttranscriptional gene silencing by rnaGO:0035194100.010
protein localization to nucleusGO:00345041210.010
circulatory system processGO:00030131970.010
endothelial cell differentiationGO:0045446410.010
nucleotide metabolic processGO:00091173320.010
adult behaviorGO:00305341350.010
cell junction assemblyGO:0034329520.010

Top1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.011
connective tissue diseaseDOID:6500.011
musculoskeletal system diseaseDOID:1700.011
bone diseaseDOID:008000100.011
disease of anatomical entityDOID:700.011