Mus musculus

87 known processes

Keap1

kelch-like ECH-associated protein 1

(Aliases: mKIAA0132,INRF2)

Keap1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein modification by small protein conjugation or removalGO:00706472070.164
macromolecule catabolic processGO:00090572810.141
regulation of cellular amine metabolic processGO:0033238200.127
protein modification by small protein conjugationGO:00324461870.118
protein catabolic processGO:00301632210.112
regulation of cellular amino acid metabolic processGO:000652150.089
positive regulation of macroautophagyGO:001623930.088
cellular amino acid metabolic processGO:00065201030.080
cellular ketone metabolic processGO:0042180840.075
macroautophagyGO:0016236210.074
modification dependent macromolecule catabolic processGO:00436321330.074
membrane organizationGO:00610242450.072
peptidyl amino acid modificationGO:00181933360.067
proteolysis involved in cellular protein catabolic processGO:00516031470.066
protein processingGO:00164851630.066
male gamete generationGO:00482322850.066
Mouse
positive regulation of protein phosphorylationGO:00019342420.065
modification dependent protein catabolic processGO:00199411330.060
protein ubiquitinationGO:00165671710.060
cellular amine metabolic processGO:0044106440.056
positive regulation of cellular amine metabolic processGO:003324050.055
chromatin modificationGO:00165681870.054
cellular homeostasisGO:00197252400.051
i kappab kinase nf kappab signalingGO:0007249850.050
chromatin organizationGO:00063252060.050
protein maturationGO:00516041760.050
amine metabolic processGO:0009308450.049
spermatogenesisGO:00072832840.047
Mouse
response to nutrient levelsGO:00316671090.046
regulation of organelle organizationGO:00330432890.046
cytokine productionGO:00018163190.045
actin cytoskeleton organizationGO:00300362200.044
regulation of cellular response to stressGO:00801351590.044
regulation of macroautophagyGO:0016241120.043
positive regulation of cellular amino acid metabolic processGO:004576430.042
negative regulation of cellular amine metabolic processGO:003323910.042
negative regulation of cellular protein metabolic processGO:00322692470.041
cellular response to starvationGO:0009267570.041
positive regulation of autophagyGO:001050890.041
negative regulation of protein modification processGO:00314001630.041
metencephalon developmentGO:0022037890.039
Mouse
cellular response to nutrient levelsGO:0031669640.038
regulation of cellular ketone metabolic processGO:0010565660.038
positive regulation of protein modification processGO:00314012990.038
establishment of protein localization to organelleGO:00725941180.037
negative regulation of cellular component organizationGO:00511291940.037
cellular macromolecule catabolic processGO:00442652060.036
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.036
immune effector processGO:00022523210.036
intracellular protein transportGO:00068862040.034
gland developmentGO:00487323300.034
cellular protein catabolic processGO:00442571550.034
cellular response to lipidGO:00713961450.034
response to extracellular stimulusGO:00099911270.033
microtubule based processGO:00070172360.033
protein oligomerizationGO:0051259670.032
cellular response to cytokine stimulusGO:00713451890.032
protein heterooligomerizationGO:0051291140.031
negative regulation of cellular amino acid metabolic processGO:004576300.031
cellular lipid metabolic processGO:00442553230.030
positive regulation of cellular catabolic processGO:00313311480.030
cytoplasmic transportGO:00164822340.030
protein acylationGO:0043543640.030
histone modificationGO:00165701590.029
spermatid developmentGO:00072861080.029
Mouse
negative regulation of protein metabolic processGO:00512482820.029
mitotic cell cycleGO:00002781950.029
cellular response to extracellular stimulusGO:0031668810.029
skeletal system developmentGO:00015013560.029
purine ribonucleotide metabolic processGO:00091502900.029
regulation of cell cycleGO:00517262810.028
oocyte axis specificationGO:000730920.028
locomotory behaviorGO:00076261950.028
Mouse
regulation of kinase activityGO:00435492490.026
cellular response to external stimulusGO:0071496880.026
apoptotic signaling pathwayGO:00971903060.026
Mouse
response to starvationGO:0042594650.025
organic cyclic compound catabolic processGO:19013612950.025
spermatid differentiationGO:00485151150.025
Mouse
cell type specific apoptotic processGO:00972852680.025
digestive system developmentGO:00551232000.024
proteasomal protein catabolic processGO:0010498980.024
immune response regulating signaling pathwayGO:00027641250.024
innate immune responseGO:00450871570.024
defense response to virusGO:0051607680.024
regulation of cellular catabolic processGO:00313292420.024
symbiosis encompassing mutualism through parasitismGO:0044403830.024
positive regulation of cell developmentGO:00107202370.024
regulation of body fluid levelsGO:00508781620.023
homeostasis of number of cellsGO:00488722100.023
Mouse
endomembrane system organizationGO:00102561470.023
nucleobase containing small molecule metabolic processGO:00550863520.023
negative regulation of phosphorus metabolic processGO:00105631840.023
positive regulation of proteolysisGO:0045862850.023
oxidation reduction processGO:00551143420.023
heterocycle catabolic processGO:00467002800.023
ubiquitin dependent protein catabolic processGO:00065111290.023
organophosphate catabolic processGO:00464342320.022
carbohydrate derivative biosynthetic processGO:19011371830.022
mapk cascadeGO:00001652810.022
myeloid cell homeostasisGO:00022621140.022
sensory perceptionGO:00076002450.022
protein localization to organelleGO:00333651850.022
cellular response to organonitrogen compoundGO:00714171450.022
adult behaviorGO:00305341350.022
Mouse
positive regulation of organelle organizationGO:00106381280.022
cation transportGO:00068123990.022
regulation of chromosome organizationGO:0033044830.021
carbohydrate derivative catabolic processGO:19011362310.021
cellular nitrogen compound catabolic processGO:00442702800.021
microtubule cytoskeleton organizationGO:00002261570.021
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.021
protein glycosylationGO:0006486550.021
synaptic transmissionGO:00072683290.021
immune response activating signal transductionGO:00027571160.021
carbohydrate metabolic processGO:00059752300.021
activation of immune responseGO:00022531380.020
interspecies interaction between organismsGO:0044419830.020
regulation of protein catabolic processGO:00421761080.020
nucleotide catabolic processGO:00091662170.020
negative regulation of molecular functionGO:00440922580.020
nucleoside phosphate catabolic processGO:19012922220.020
metal ion homeostasisGO:00550651890.020
transmembrane transportGO:00550854120.020
viral processGO:0016032410.020
negative regulation of protein phosphorylationGO:00019331260.019
regulation of multi organism processGO:00439001110.019
muscle tissue developmentGO:00605373080.019
small gtpase mediated signal transductionGO:0007264970.019
response to endoplasmic reticulum stressGO:0034976530.019
t cell activationGO:00421102890.019
response to lipopolysaccharideGO:00324961280.019
regulation of proteolysisGO:00301621640.019
ribose phosphate metabolic processGO:00196932910.019
regulation of ossificationGO:00302781120.019
nitrogen compound transportGO:00717052710.019
positive regulation of nervous system developmentGO:00519622210.019
regulation of transferase activityGO:00513382630.019
response to inorganic substanceGO:0010035960.019
response to organic cyclic compoundGO:00140701980.019
wound healingGO:00420601570.019
protein targetingGO:00066051430.018
aromatic compound catabolic processGO:00194392860.018
muscle cell differentiationGO:00426922610.018
protein importGO:00170381010.018
regulation of defense responseGO:00313472330.018
purine nucleotide metabolic processGO:00061633020.018
purine ribonucleoside metabolic processGO:00461282410.018
regionalizationGO:00030023370.018
ras protein signal transductionGO:0007265770.018
posttranscriptional regulation of gene expressionGO:00106081550.018
mitochondrion organizationGO:00070051340.018
negative regulation of protein maturationGO:1903318790.017
purine nucleoside triphosphate catabolic processGO:00091462030.017
striated muscle tissue developmentGO:00147062930.017
cellular chemical homeostasisGO:00550822150.017
ossificationGO:00015032160.017
covalent chromatin modificationGO:00165691630.017
peptidyl lysine modificationGO:0018205770.017
development of primary sexual characteristicsGO:00451371430.017
Mouse
divalent inorganic cation transportGO:00725111780.016
placenta developmentGO:00018901400.016
epithelial cell proliferationGO:00506731740.016
dephosphorylationGO:00163111290.016
positive regulation of protein catabolic processGO:0045732600.016
maintenance of locationGO:0051235890.016
cellular response to molecule of bacterial originGO:0071219830.016
ribonucleoside metabolic processGO:00091192450.016
single organism nuclear importGO:1902593950.016
regulation of cellular component biogenesisGO:00440871810.016
regulation of endopeptidase activityGO:0052548890.016
cellular response to cadmium ionGO:007127630.016
reactive nitrogen species metabolic processGO:200105700.016
organic hydroxy compound metabolic processGO:19016152030.016
cellular ion homeostasisGO:00068731650.016
regulation of protein maturationGO:1903317960.016
autophagyGO:0006914450.016
alcohol metabolic processGO:00060661160.016
regulation of cytokine productionGO:00018172660.016
regulation of anatomical structure sizeGO:00900661780.016
peptidyl tyrosine modificationGO:00182121450.016
regulation of cell activationGO:00508652890.016
intrinsic apoptotic signaling pathwayGO:00971931320.016
Mouse
regulation of ion transportGO:00432692150.016
positive regulation of cell deathGO:00109422240.016
positive regulation of kinase activityGO:00336741550.016
negative regulation of ossificationGO:0030279490.016
cellular protein complex assemblyGO:00436231160.016
internal protein amino acid acetylationGO:0006475420.015
telencephalon developmentGO:00215371860.015
organelle fissionGO:00482851700.015
small molecule catabolic processGO:0044282710.015
negative regulation of organelle organizationGO:0010639900.015
regulation of hormone levelsGO:00108172110.015
striated muscle cell developmentGO:00550021250.015
glycosyl compound metabolic processGO:19016572460.015
positive regulation of response to woundingGO:1903036660.015
cerebellum developmentGO:0021549770.015
Mouse
cell maturationGO:00484691270.015
viral life cycleGO:0019058360.015
translationGO:0006412930.015
glycoprotein metabolic processGO:00091001160.015
central nervous system neuron differentiationGO:00219531620.015
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.015
digestive tract developmentGO:00485651900.015
nucleoside catabolic processGO:00091642060.015
germ cell developmentGO:00072811850.015
Mouse
response to acid chemicalGO:00011011110.015
regulation of membrane potentialGO:00423911920.015
pole plasm assemblyGO:000731520.015
defense response to other organismGO:00985421970.015
response to granulocyte macrophage colony stimulating factorGO:009701230.015
negative regulation of protein processingGO:0010955790.014
cellularizationGO:000734910.014
forebrain developmentGO:00309003020.014
protein localization to nucleusGO:00345041210.014
nucleoside phosphate metabolic processGO:00067533380.014
negative regulation of intracellular signal transductionGO:19025321670.014
Mouse
purine nucleoside metabolic processGO:00422782410.014
wnt signaling pathwayGO:00160551880.014
ribonucleotide metabolic processGO:00092592910.014
hindbrain developmentGO:00309021280.014
Mouse
axonogenesisGO:00074092740.014
regulation of cell cycle processGO:00105641600.014
response to peptide hormoneGO:00434341270.014
nucleotide metabolic processGO:00091173320.014
regulation of chromatin organizationGO:1902275570.014
purine containing compound metabolic processGO:00725213110.014
regulation of mapk cascadeGO:00434082480.014
negative regulation of proteolysisGO:0045861740.013
divalent metal ion transportGO:00708381720.013
cerebellar purkinje cell layer developmentGO:0021680260.013
Mouse
sensory organ morphogenesisGO:00905962420.013
organonitrogen compound catabolic processGO:19015652640.013
compound eye developmentGO:004874910.013
cellular response to dna damage stimulusGO:00069742070.013
regulation of secretionGO:00510462740.013
regulation of cytoplasmic transportGO:19036491120.013
regulation of stress activated mapk cascadeGO:0032872690.013
regulation of actin filament based processGO:0032970990.013
stress activated mapk cascadeGO:0051403800.013
cytokine biosynthetic processGO:0042089680.013
leukocyte differentiationGO:00025213420.013
negative regulation of neuron deathGO:1901215980.013
cellular carbohydrate metabolic processGO:00442621190.013
positive regulation of intracellular transportGO:0032388700.013
cell adhesionGO:00071553290.013
negative regulation of phosphorylationGO:00423261660.013
negative regulation of phosphate metabolic processGO:00459361840.013
intracellular mrna localizationGO:000829840.013
regulation of autophagyGO:0010506300.013
cellular response to organic cyclic compoundGO:0071407870.013
regulation of reactive oxygen species metabolic processGO:2000377400.013
cerebellar cortex developmentGO:0021695480.013
Mouse
response to oxygen levelsGO:0070482620.013
ion transmembrane transportGO:00342203610.013
negative regulation of immune system processGO:00026832090.013
dna metabolic processGO:00062593030.012
positive regulation of transferase activityGO:00513471670.012
response to organonitrogen compoundGO:00102432460.012
positive regulation of protein kinase activityGO:00458601440.012
calcium ion transportGO:00068161590.012
glycoprotein biosynthetic processGO:0009101890.012
regulation of cell migrationGO:00303342190.012
cell junction maintenanceGO:003433140.012
response to epidermal growth factorGO:007084940.012
cytokine mediated signaling pathwayGO:00192211150.012
organelle localizationGO:00516401790.012
regulation of cell growthGO:0001558910.012
embryonic organ morphogenesisGO:00485622760.012
regulation of mitotic cell cycleGO:00073461260.012
regulation of translationGO:0006417710.012
regulation of t cell activationGO:00508631700.012
developmental maturationGO:00217001930.012
regulation of cellular protein catabolic processGO:1903362610.012
regulation of neuron differentiationGO:00456642810.012
purine ribonucleoside triphosphate metabolic processGO:00092052200.012
body fluid secretionGO:0007589530.012
anion transportGO:00068201770.012
ribonucleoside catabolic processGO:00424542060.012
regulation of lymphocyte activationGO:00512492400.012
oocyte anterior posterior axis specificationGO:000731420.012
amide transportGO:00428861380.012
gastrulationGO:00073691160.012
cartilage developmentGO:00512161400.012
positive regulation of cell cycleGO:0045787920.012
regulation of system processGO:00440572000.012
cellular metal ion homeostasisGO:00068751510.012
b cell activationGO:00421131610.012
meiosis iGO:0007127600.011
meiotic nuclear divisionGO:00071261150.011
epidermis developmentGO:00085441870.011
regulation of homeostatic processGO:00328441820.011
nucleoside metabolic processGO:00091162460.011
glial cell differentiationGO:00100011310.011
response to peptideGO:19016521360.011
regulation of chromatin modificationGO:1903308570.011
connective tissue developmentGO:00614481790.011
localization within membraneGO:005166840.011
regulation of neuron deathGO:19012141340.011
fatty acid metabolic processGO:00066311210.011
asymmetric stem cell divisionGO:009872230.011
multicellular organismal signalingGO:0035637910.011
positive regulation of cell activationGO:00508671580.011
organophosphate biosynthetic processGO:00904071220.011
organonitrogen compound biosynthetic processGO:19015661920.011
muscle system processGO:00030121410.011
lymphocyte differentiationGO:00300982420.011
stem cell differentiationGO:00488632680.011
regulation of response to biotic stimulusGO:0002831380.011
hematopoietic progenitor cell differentiationGO:00022441430.011
nuclear transportGO:00511691390.011
cellular response to lipopolysaccharideGO:0071222770.011
cellular response to granulocyte macrophage colony stimulating factor stimulusGO:009701130.011
regulation of hydrolase activityGO:00513362460.011
establishment or maintenance of cytoskeleton polarityGO:003095220.011
response to amino acidGO:0043200370.011
ribonucleoside triphosphate catabolic processGO:00092031990.010
regulation of cell motilityGO:20001452360.010
protein polymerizationGO:0051258570.010
leukocyte proliferationGO:00706611720.010
adult locomotory behaviorGO:0008344910.010
Mouse
nuclear divisionGO:00002801580.010
activation of cysteine type endopeptidase activityGO:0097202270.010
circulatory system processGO:00030131970.010
retrograde transport endosome to golgiGO:004214720.010
neuron deathGO:00709971540.010
cell divisionGO:00513011200.010
pharynx developmentGO:006046510.010
carbohydrate homeostasisGO:00335001280.010
lymphocyte proliferationGO:00466511640.010
negative regulation of transferase activityGO:0051348850.010
regulation of blood pressureGO:0008217930.010
gonad developmentGO:00084061410.010
Mouse
ribonucleotide catabolic processGO:00092612080.010
peptidyl lysine acetylationGO:0018394450.010
monocarboxylic acid metabolic processGO:00327871910.010

Keap1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
connective tissue diseaseDOID:6500.322
disease of anatomical entityDOID:700.322
musculoskeletal system diseaseDOID:1700.322
bone diseaseDOID:008000100.074
bone remodeling diseaseDOID:008000500.073
nervous system diseaseDOID:86300.031
muscular diseaseDOID:008000000.027
muscle tissue diseaseDOID:6600.022
central nervous system diseaseDOID:33100.021
disease of metabolismDOID:001466700.017
disease of cellular proliferationDOID:1456600.014
cancerDOID:16200.012
sensory system diseaseDOID:005015500.012
neurodegenerative diseaseDOID:128900.010
organ system cancerDOID:005068600.010