Mus musculus

73 known processes

Cul3

cullin 3

(Aliases: mKIAA0617,AI467304,AW146203)

Cul3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
proteolysis involved in cellular protein catabolic processGO:00516031470.951
cellular protein catabolic processGO:00442571550.796
modification dependent macromolecule catabolic processGO:00436321330.734
cellular macromolecule catabolic processGO:00442652060.702
proteasomal protein catabolic processGO:0010498980.627
protein catabolic processGO:00301632210.551
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.476
cellular response to dna damage stimulusGO:00069742070.379
establishment of protein localization to organelleGO:00725941180.369
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.339
transforming growth factor beta receptor signaling pathwayGO:0007179710.338
germ cell developmentGO:00072811850.336
circadian rhythmGO:00076231140.334
spermatid differentiationGO:00485151150.300
regionalizationGO:00030023370.293
cellular response to growth factor stimulusGO:00713631970.292
macromolecule catabolic processGO:00090572810.290
cellular response to cytokine stimulusGO:00713451890.264
protein modification by small protein conjugation or removalGO:00706472070.261
Human
stem cell differentiationGO:00488632680.256
regulation of translationGO:0006417710.228
pole plasm assemblyGO:000731520.225
negative regulation of protein metabolic processGO:00512482820.224
protein localization to organelleGO:00333651850.222
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296820.221
regulation of protein import into nucleusGO:0042306520.221
regulation of cytoplasmic transportGO:19036491120.219
oocyte anterior posterior axis specificationGO:000731420.218
modification dependent protein catabolic processGO:00199411330.187
translationGO:0006412930.184
regulation of cellular response to stressGO:00801351590.180
ubiquitin dependent protein catabolic processGO:00065111290.173
intracellular protein transportGO:00068862040.172
protein modification by small protein conjugationGO:00324461870.169
Human
regulation of transcription factor import into nucleusGO:0042990240.159
compound eye developmentGO:004874910.156
regulation of apoptotic signaling pathwayGO:20012331970.155
rhythmic processGO:00485111740.154
protein modification by small protein removalGO:0070646210.146
mesenchyme developmentGO:00604851520.141
positive regulation of nfat protein import into nucleusGO:005153310.132
response to transforming growth factor betaGO:0071559880.132
regulation of intracellular transportGO:00323861590.129
regulation of mitotic cell cycleGO:00073461260.128
Human
purine ribonucleoside triphosphate catabolic processGO:00092071990.122
cellular response to insulin stimulusGO:0032869780.115
developmental maturationGO:00217001930.114
organelle fissionGO:00482851700.113
Human
negative regulation of t cell mediated cytotoxicityGO:000191530.112
regulation of response to dna damage stimulusGO:2001020340.112
regulation of synaptic growth at neuromuscular junctionGO:000858240.111
negative regulation of cellular protein metabolic processGO:00322692470.111
cellular amine metabolic processGO:0044106440.109
positive regulation of intracellular transportGO:0032388700.104
spermatid developmentGO:00072861080.103
posttranscriptional regulation of gene expressionGO:00106081550.098
mitotic cell cycleGO:00002781950.096
Human
stem cell developmentGO:00488642190.094
intracellular mrna localizationGO:000829840.091
ribonucleoside monophosphate metabolic processGO:0009161800.091
nitrogen compound transportGO:00717052710.088
regulation of intracellular protein transportGO:0033157820.087
positive regulation of cellular catabolic processGO:00313311480.086
Human
jnk cascadeGO:0007254720.086
spermatogenesisGO:00072832840.086
nuclear divisionGO:00002801580.086
Human
nucleobase containing small molecule metabolic processGO:00550863520.086
nucleotide metabolic processGO:00091173320.085
maternal determination of anterior posterior axis embryoGO:000835820.081
purine containing compound metabolic processGO:00725213110.080
dna repairGO:00062811070.079
oocyte developmentGO:0048599330.079
protein importGO:00170381010.078
synapse organizationGO:00508081250.078
cellular response to transforming growth factor beta stimulusGO:0071560880.076
axonogenesisGO:00074092740.074
mitochondrion transport along microtubuleGO:004749730.072
response to osmotic stressGO:0006970210.072
cytoplasmic transportGO:00164822340.071
Human
protein targetingGO:00066051430.070
membrane organizationGO:00610242450.069
Human
locomotory behaviorGO:00076261950.068
nuclear importGO:0051170950.067
ossificationGO:00015032160.067
regulation of nucleocytoplasmic transportGO:0046822730.067
ras protein signal transductionGO:0007265770.066
Human
lipid localizationGO:00108761260.065
carbohydrate derivative biosynthetic processGO:19011371830.065
meiotic cell cycle processGO:1903046770.065
oocyte axis specificationGO:000730920.065
gtp metabolic processGO:00460391440.064
dendrite developmentGO:00163581150.064
protein ubiquitinationGO:00165671710.063
Human
regulation of establishment of protein localizationGO:00702011810.063
homeostasis of number of cellsGO:00488722100.061
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787250.060
regulation of jnk cascadeGO:0046328620.060
adult behaviorGO:00305341350.058
regulation of protein catabolic processGO:00421761080.058
Human
nucleocytoplasmic transportGO:00069131390.057
mitotic cell cycle processGO:19030471590.057
Human
single organism nuclear importGO:1902593950.055
regulation of mrna processingGO:0050684410.054
cerebellum developmentGO:0021549770.053
negative regulation of phosphorylationGO:00423261660.052
regulation of cellular component biogenesisGO:00440871810.052
protein polyubiquitinationGO:0000209330.051
Human
intrinsic apoptotic signaling pathwayGO:00971931320.051
muscle cell differentiationGO:00426922610.050
golgi localizationGO:005164540.050
response to growth factorGO:00708481980.050
leukocyte aggregationGO:007048610.050
oocyte constructionGO:000730820.049
cell divisionGO:00513011200.049
regulation of transferase activityGO:00513382630.048
meiotic cell cycleGO:00513211220.048
regulation of organelle organizationGO:00330432890.048
Human
polyamine biosynthetic processGO:000659620.048
nucleoside metabolic processGO:00091162460.047
ribonucleoside metabolic processGO:00091192450.047
cellularizationGO:000734910.046
regulation of protein transportGO:00512231630.046
nucleoside triphosphate catabolic processGO:00091432050.046
chromatin organizationGO:00063252060.046
purine ribonucleotide catabolic processGO:00091542080.045
regulation of androgen receptor signaling pathwayGO:006076530.045
multicellular organismal agingGO:0010259240.044
Worm
positive regulation of mitotic sister chromatid separationGO:190197020.043
Human
innate immune responseGO:00450871570.043
positive regulation of dna templated transcription elongationGO:003278620.042
positive regulation of protein localization to nucleusGO:1900182300.042
mapk cascadeGO:00001652810.042
purine ribonucleoside metabolic processGO:00461282410.042
striated muscle tissue developmentGO:00147062930.042
female gamete generationGO:0007292740.041
regulation of cellular protein catabolic processGO:1903362610.041
Human
synaptic growth at neuromuscular junctionGO:005112460.041
purine nucleotide metabolic processGO:00061633020.040
negative regulation of cell proliferationGO:00082852960.039
positive regulation of cellular protein catabolic processGO:1903364340.038
Human
endomembrane system organizationGO:00102561470.038
stress activated mapk cascadeGO:0051403800.037
oocyte differentiationGO:0009994350.037
positive regulation of muscle adaptationGO:001474420.036
skeletal muscle organ developmentGO:00605381630.036
nucleoside catabolic processGO:00091642060.036
establishment of organelle localizationGO:00516561220.036
Human Worm
protein localization to nucleusGO:00345041210.035
cellular ketone metabolic processGO:0042180840.035
regulation of protein localizationGO:00328802310.034
nucleoside phosphate metabolic processGO:00067533380.034
protein deubiquitinationGO:0016579190.034
intracellular receptor signaling pathwayGO:0030522740.034
purine nucleoside metabolic processGO:00422782410.033
amide transportGO:00428861380.033
maternal process involved in female pregnancyGO:0060135320.032
regulation of protein targetingGO:1903533610.032
regulation of cellular catabolic processGO:00313292420.032
Human
cellular response to organonitrogen compoundGO:00714171450.032
centrosome duplicationGO:0051298160.032
regulation of defense responseGO:00313472330.032
male gamete generationGO:00482322850.032
negative regulation of epithelial cell proliferationGO:0050680640.031
adult locomotory behaviorGO:0008344910.031
lateral inhibitionGO:004633110.031
regulation of protein localization to nucleusGO:1900180600.031
nucleoside phosphate catabolic processGO:19012922220.031
organelle localizationGO:00516401790.030
Human Worm
intracellular steroid hormone receptor signaling pathwayGO:0030518290.030
synaptic transmissionGO:00072683290.030
centrosome organizationGO:0051297260.030
positive regulation of protein phosphorylationGO:00019342420.029
cell maturationGO:00484691270.029
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243340.029
regulation of kinase activityGO:00435492490.029
forebrain developmentGO:00309003020.029
negative regulation of immune system processGO:00026832090.028
negative regulation of phosphorus metabolic processGO:00105631840.028
cellular amino acid metabolic processGO:00065201030.028
dna integrity checkpointGO:0031570280.028
regulation of cell cycle processGO:00105641600.028
Human
rna polymerase ii transcriptional preinitiation complex assemblyGO:005112330.028
dephosphorylationGO:00163111290.028
covalent chromatin modificationGO:00165691630.028
rna processingGO:00063961050.027
organonitrogen compound catabolic processGO:19015652640.027
purine ribonucleoside catabolic processGO:00461302050.027
nuclear transportGO:00511691390.027
ameboidal type cell migrationGO:00016671280.027
negative regulation of mitotic cell cycleGO:0045930580.027
neuron projection extensionGO:1990138640.027
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.027
Human
spinal cord oligodendrocyte cell differentiationGO:002152930.026
ribonucleotide metabolic processGO:00092592910.026
metencephalon developmentGO:0022037890.025
cellular response to arsenic containing substanceGO:007124340.025
synapsisGO:0007129340.025
negative regulation of protein modification processGO:00314001630.025
centrosome separationGO:005129940.025
protein import into nucleusGO:0006606950.024
ribonucleoside catabolic processGO:00424542060.024
memoryGO:0007613580.024
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.024
purine nucleoside triphosphate catabolic processGO:00091462030.024
peptide transportGO:00158331330.024
apoptotic signaling pathwayGO:00971903060.023
endoplasmic reticulum tubular network organizationGO:007178610.023
negative regulation of protein phosphorylationGO:00019331260.023
cell growthGO:00160491300.023
skeletal muscle cell differentiationGO:0035914660.023
purine nucleotide catabolic processGO:00061952110.023
regulation of proteolysisGO:00301621640.023
Human
female sex differentiationGO:0046660840.022
ribonucleoside triphosphate metabolic processGO:00091992200.022
neural tube developmentGO:00219151600.022
nucleus organizationGO:0006997450.022
regulation of cell projection organizationGO:00313442060.022
regulation of system processGO:00440572000.022
positive regulation of proteolysisGO:0045862850.022
Human
mesenchymal cell differentiationGO:00487621070.022
guanosine containing compound metabolic processGO:19010681440.022
microtubule organizing center organizationGO:0031023280.022
regulation of chromatin organizationGO:1902275570.021
n terminal protein amino acid modificationGO:003136560.021
neural precursor cell proliferationGO:00613511210.021
regulation of protein complex assemblyGO:0043254830.021
gtp catabolic processGO:00061841430.021
regulation of planar cell polarity pathway involved in axis elongationGO:200004030.021
myotube differentiationGO:00149021050.021
alternative mrna splicing via spliceosomeGO:0000380120.021
segmentationGO:0035282930.021
maintenance of locationGO:0051235890.021
establishment of vesicle localizationGO:0051650810.021
Human
positive regulation of response to dna damage stimulusGO:2001022140.021
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436230.021
Human
purine containing compound catabolic processGO:00725232130.021
circulatory system processGO:00030131970.021
muscle tissue developmentGO:00605373080.021
glucose homeostasisGO:00425931280.021
mitotic nuclear divisionGO:0007067480.020
Human
positive regulation of protein import into nucleusGO:0042307260.020
mesenchymal cell developmentGO:0014031930.020
transcription factor import into nucleusGO:0042991260.020
amine metabolic processGO:0009308450.020
positive regulation of cell cycleGO:0045787920.020
Human
stress activated protein kinase signaling cascadeGO:0031098810.019
negative regulation of translationGO:0017148220.019
mesodermal cell migrationGO:000807840.019
determination of adult lifespanGO:0008340110.019
Worm
carbohydrate derivative catabolic processGO:19011362310.019
regulation of chromosome organizationGO:0033044830.019
Human
mitochondrion distributionGO:004831140.019
establishment of protein localization to endoplasmic reticulumGO:007259920.019
hyperosmotic responseGO:000697240.019
regulation of stress activated mapk cascadeGO:0032872690.019
cellular chemical homeostasisGO:00550822150.019
nucleotide catabolic processGO:00091662170.019
regulation of membrane potentialGO:00423911920.019
stem cell maintenanceGO:00198271300.019
establishment of mitochondrion localizationGO:005165440.019
regulation of cellular ketone metabolic processGO:0010565660.019
regulation of cellular component sizeGO:00325351210.018
heterocycle catabolic processGO:00467002800.018
positive regulation of ran gtpase activityGO:003285330.018
negative regulation of cellular response to growth factor stimulusGO:0090288460.018
cellular response to hormone stimulusGO:00328701500.018
positive regulation of organelle organizationGO:00106381280.018
Human
purine nucleoside triphosphate metabolic processGO:00091442260.018
cellular homeostasisGO:00197252400.018
positive regulation of nucleocytoplasmic transportGO:0046824300.017
establishment of meiotic spindle orientationGO:005129610.017
purine ribonucleotide metabolic processGO:00091502900.017
morphogenesis of embryonic epitheliumGO:00163311590.017
positive regulation of protein kinase activityGO:00458601440.017
regulation of mitotic cell cycle phase transitionGO:1901990730.017
Human
cellular response to carbohydrate stimulusGO:0071322500.017
positive regulation of ubiquitin protein transferase activityGO:005144340.017
multi multicellular organism processGO:00447061090.017
rna splicingGO:0008380540.017
regulation of epithelial cell proliferationGO:00506781410.017
epithelial cell migrationGO:0010631630.017
male meiosis iGO:0007141160.017
fertilizationGO:00095661270.016
Worm
defense response to gram negative bacteriumGO:0050829280.016
regulation of ion transportGO:00432692150.016
connective tissue developmentGO:00614481790.016
chromatin modificationGO:00165681870.016
response to oxidative stressGO:00069791230.016
histone modificationGO:00165701590.016
rna localizationGO:0006403230.016
response to organonitrogen compoundGO:00102432460.016
regulation of secretionGO:00510462740.016
ribose phosphate metabolic processGO:00196932910.016
body morphogenesisGO:0010171450.016
neuron migrationGO:00017641220.016
regulation of neuron differentiationGO:00456642810.016
guanosine containing compound catabolic processGO:19010691440.016
response to nutrient levelsGO:00316671090.016
nucleus localizationGO:0051647200.016
Worm
epithelium migrationGO:0090132630.016
pallium developmentGO:00215431200.016
microtubule nucleationGO:000702020.016
regulation of cell migrationGO:00303342190.016
negative regulation of cell growthGO:0030308440.015
rna splicing via transesterification reactionsGO:0000375430.015
ribonucleoprotein complex subunit organizationGO:0071826280.015
cellular nitrogen compound catabolic processGO:00442702800.015
leukocyte mediated cytotoxicityGO:0001909620.015
learning or memoryGO:00076111480.015
regulation of synapse assemblyGO:0051963290.015
nfat protein import into nucleusGO:005153160.015
positive regulation of transferase activityGO:00513471670.015
meiotic nuclear divisionGO:00071261150.015
protein autophosphorylationGO:0046777610.015
cellular glucose homeostasisGO:0001678520.015
regulation of ossificationGO:00302781120.014
oogenesisGO:0048477560.014
cellular response to monosaccharide stimulusGO:0071326470.014
cation transportGO:00068123990.014
urogenital system developmentGO:00016552610.014
cellular response to peptide hormone stimulusGO:0071375920.014
response to radiationGO:00093141650.014
organophosphate catabolic processGO:00464342320.014
glycosyl compound metabolic processGO:19016572460.014
regulation of ion transmembrane transportGO:00347651190.014
axon guidanceGO:00074111410.014
negative regulation of transforming growth factor beta receptor signaling pathwayGO:0030512260.014
neuron projection guidanceGO:00974851410.014
negative regulation of mapk cascadeGO:0043409650.014
defense response to other organismGO:00985421970.013
mrna metabolic processGO:0016071840.013
cellular response to prostaglandin stimulusGO:007137920.013
dna metabolic processGO:00062593030.013
digestive tract developmentGO:00485651900.013
epithelial tube morphogenesisGO:00605623030.013
hormone secretionGO:00468791280.013
regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589820.013
positive regulation of protein transportGO:0051222930.013
golgi vesicle transportGO:0048193300.013
Human
regulation of systemic arterial blood pressure by vasopressinGO:000199230.013
lymphocyte proliferationGO:00466511640.013
negative regulation of defense responseGO:0031348770.013
regulation of cell motilityGO:20001452360.013
mitotic cytokinesisGO:000028140.013
signal transduction by p53 class mediatorGO:0072331510.013
negative regulation of phosphate metabolic processGO:00459361840.013
regulation of nfat protein import into nucleusGO:005153240.013
female meiotic divisionGO:0007143210.012
regulation of anatomical structure sizeGO:00900661780.012
ribonucleotide catabolic processGO:00092612080.012
regulation of cellular amine metabolic processGO:0033238200.012
striated muscle cell developmentGO:00550021250.012
positive regulation of nervous system developmentGO:00519622210.012
neuron deathGO:00709971540.012
cell cycle switching mitotic to meiotic cell cycleGO:005172810.012
response to temperature stimulusGO:0009266550.012
regulation of innate immune responseGO:0045088910.012
regulation of transmembrane transportGO:00347621280.012
carbohydrate homeostasisGO:00335001280.012
protein polymerizationGO:0051258570.012
regulation of high voltage gated calcium channel activityGO:190184120.012
microtubule cytoskeleton organizationGO:00002261570.012
cerebellar cortex developmentGO:0021695480.012
regulation of transforming growth factor beta receptor signaling pathwayGO:0017015430.012
regulation of cardiac muscle adaptationGO:001061220.011
regulation of cellular response to growth factor stimulusGO:0090287820.011
leukocyte homeostasisGO:0001776790.011
double strand break repairGO:0006302480.011
peptidyl amino acid modificationGO:00181933360.011
response to light stimulusGO:00094161350.011
regulation of mapk cascadeGO:00434082480.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.011
regulation of muscle system processGO:0090257800.011
cell type specific apoptotic processGO:00972852680.011
androgen receptor signaling pathwayGO:003052180.011
n terminal protein lipidationGO:000649850.011
dna templated transcriptional preinitiation complex assemblyGO:007089740.011
phagocytosisGO:0006909660.011
positive regulation of transcription factor import into nucleusGO:004299380.011
sensory perception of touchGO:005097520.011
regulation of peptide transportGO:0090087910.011
negative regulation of dna replicationGO:000815640.011
regulation of actin filament based processGO:0032970990.011
regulation of ran gtpase activityGO:003231630.011
cytokinesisGO:0000910170.011
Human
t cell activationGO:00421102890.011
negative regulation of protein transportGO:0051224460.010
synapse assemblyGO:0007416560.010
regulation of histone modificationGO:0031056560.010
calcium ion transportGO:00068161590.010
bmp signaling pathwayGO:0030509930.010
positive regulation of apoptotic processGO:00430652170.010
regulation of neural precursor cell proliferationGO:2000177700.010
establishment or maintenance of cell polarityGO:0007163860.010
neural tube closureGO:0001843900.010
determination of left right symmetryGO:0007368800.010
response to monosaccharideGO:0034284670.010
microtubule based processGO:00070172360.010
response to molecule of bacterial originGO:00022371430.010

Cul3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.052
disease of anatomical entityDOID:700.052
sensory system diseaseDOID:005015500.039
eye and adnexa diseaseDOID:149200.039
neurodegenerative diseaseDOID:128900.027
amyotrophic lateral sclerosisDOID:33200.027
motor neuron diseaseDOID:23100.027
central nervous system diseaseDOID:33100.027
musculoskeletal system diseaseDOID:1700.014
disease of cellular proliferationDOID:1456600.011
cancerDOID:16200.011
organ system cancerDOID:005068600.011
endocrine gland cancerDOID:17000.011