IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Ppic

peptidylprolyl isomerase C

(Aliases: CyP-20c)

Ensembl: ENSMUSG00000024538
Entrez: 19038
UniProtKB: P30412
UniProtKB: Q3UC73

Process Predictions
Disease Predictions

Ppic biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
extracellular matrix organization	GO:0030198	147	0.274
extracellular structure organization	GO:0043062	148	0.259
peptidyl proline hydroxylation	GO:0019511	3	0.209
chondrocyte development	GO:0002063	24	0.133
protein hydroxylation	GO:0018126	4	0.132
signal transduction in absence of ligand	GO:0038034	55	0.123
telencephalon development	GO:0021537	186	0.096
cellular response to growth factor stimulus	GO:0071363	197	0.081
collagen fibril organization	GO:0030199	32	0.079
ossification	GO:0001503	216	0.068
glycoprotein metabolic process	GO:0009100	116	0.066
peptidyl amino acid modification	GO:0018193	336	0.064	Yeast
positive regulation of cell death	GO:0010942	224	0.060
response to growth factor	GO:0070848	198	0.054
response to transforming growth factor beta	GO:0071559	88	0.054
extrinsic apoptotic signaling pathway	GO:0097191	126	0.053
response to acid chemical	GO:0001101	111	0.049
proteoglycan metabolic process	GO:0006029	38	0.048
ear development	GO:0043583	200	0.046
protein folding	GO:0006457	28	0.043
negative regulation of protein metabolic process	GO:0051248	282	0.042
negative regulation of nik nf kappab signaling	GO:1901223	2	0.041
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.040
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.039
anion transport	GO:0006820	177	0.034
sensory organ morphogenesis	GO:0090596	242	0.033
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.033
cell type specific apoptotic process	GO:0097285	268	0.032
inner ear morphogenesis	GO:0042472	101	0.032
dna metabolic process	GO:0006259	303	0.030
positive regulation of defense response	GO:0031349	124	0.030
ras protein signal transduction	GO:0007265	77	0.030
skeletal system development	GO:0001501	356	0.030
monocarboxylic acid metabolic process	GO:0032787	191	0.029
regulation of plasminogen activation	GO:0010755	4	0.029
positive regulation of programmed cell death	GO:0043068	218	0.029
negative regulation of hydrolase activity	GO:0051346	71	0.029
cell substrate adhesion	GO:0031589	130	0.029
apoptotic signaling pathway	GO:0097190	306	0.028
protein processing	GO:0016485	163	0.028
regulation of peptidase activity	GO:0052547	96	0.027
forebrain development	GO:0030900	302	0.027
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.027
regulation of response to wounding	GO:1903034	189	0.026
response to organic cyclic compound	GO:0014070	198	0.026
regulation of cell migration	GO:0030334	219	0.026
sensory perception	GO:0007600	245	0.026
cellular response to lipid	GO:0071396	145	0.025
peptidyl proline modification	GO:0018208	6	0.025	Yeast
regulation of protein localization	GO:0032880	231	0.025
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.025
homeostasis of number of cells	GO:0048872	210	0.025
protein maturation	GO:0051604	176	0.025
cerebral cortex development	GO:0021987	86	0.025
nucleotide catabolic process	GO:0009166	217	0.024
small gtpase mediated signal transduction	GO:0007264	97	0.024
negative regulation of molecular function	GO:0044092	258	0.024
cellular amino acid metabolic process	GO:0006520	103	0.024
cellular nitrogen compound catabolic process	GO:0044270	280	0.024
muscle fiber development	GO:0048747	76	0.023
rho protein signal transduction	GO:0007266	32	0.023
regulation of cell cycle	GO:0051726	281	0.023
chondrocyte differentiation	GO:0002062	72	0.023
anatomical structure homeostasis	GO:0060249	145	0.023
regulation of proteolysis	GO:0030162	164	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.022
nitrogen compound transport	GO:0071705	271	0.022
protein secretion	GO:0009306	111	0.022
regulation of protein transport	GO:0051223	163	0.022
negative regulation of nervous system development	GO:0051961	156	0.022
regulation of body fluid levels	GO:0050878	162	0.022
carboxylic acid transport	GO:0046942	100	0.022
single organismal cell cell adhesion	GO:0016337	131	0.021
bone development	GO:0060348	120	0.021
cellular response to hormone stimulus	GO:0032870	150	0.021
palate development	GO:0060021	76	0.021
connective tissue development	GO:0061448	179	0.021
immune response regulating signaling pathway	GO:0002764	125	0.021
skeletal system morphogenesis	GO:0048705	203	0.020
tissue homeostasis	GO:0001894	115	0.020
regulation of apoptotic signaling pathway	GO:2001233	197	0.020
organic acid transport	GO:0015849	101	0.020
regulation of secretion by cell	GO:1903530	249	0.020
endoderm development	GO:0007492	45	0.020
regulation of multi organism process	GO:0043900	111	0.020
organic anion transport	GO:0015711	137	0.020
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	16	0.019
embryonic organ morphogenesis	GO:0048562	276	0.019
leukocyte differentiation	GO:0002521	342	0.019
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.019
regulation of wnt signaling pathway	GO:0030111	123	0.019
positive regulation of secretion by cell	GO:1903532	114	0.019
endomembrane system organization	GO:0010256	147	0.018
activation of immune response	GO:0002253	138	0.018
positive regulation of cell development	GO:0010720	237	0.018
cellular response to epidermal growth factor stimulus	GO:0071364	4	0.018
cell growth	GO:0016049	130	0.018
negative regulation of phosphorylation	GO:0042326	166	0.018
purine nucleotide catabolic process	GO:0006195	211	0.018
cellular response to acid chemical	GO:0071229	68	0.018
negative regulation of cell proliferation	GO:0008285	296	0.018
i kappab kinase nf kappab signaling	GO:0007249	85	0.018
regulation of protein secretion	GO:0050708	82	0.017
negative regulation of cell adhesion	GO:0007162	45	0.017
aromatic compound catabolic process	GO:0019439	286	0.017
muscle tissue development	GO:0060537	308	0.017
positive regulation of proteolysis	GO:0045862	85	0.017
positive regulation of hydrolase activity	GO:0051345	148	0.017
blood coagulation	GO:0007596	76	0.017
mineralocorticoid biosynthetic process	GO:0006705	1	0.017
blood vessel morphogenesis	GO:0048514	285	0.017
immune effector process	GO:0002252	321	0.017
nucleoside metabolic process	GO:0009116	246	0.017
negative regulation of protein modification process	GO:0031400	163	0.016
epithelial cell proliferation	GO:0050673	174	0.016
organophosphate catabolic process	GO:0046434	232	0.016
regulation of secretion	GO:0051046	274	0.016
posttranscriptional regulation of gene expression	GO:0010608	155	0.016
endochondral bone morphogenesis	GO:0060350	50	0.016
protein catabolic process	GO:0030163	221	0.016
appendage development	GO:0048736	166	0.016
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.016
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.016
cardiac muscle tissue morphogenesis	GO:0055008	44	0.016
endoderm formation	GO:0001706	20	0.016
negative regulation of intracellular signal transduction	GO:1902532	167	0.016
purine nucleoside catabolic process	GO:0006152	205	0.015
nucleoside triphosphate catabolic process	GO:0009143	205	0.015
organelle localization	GO:0051640	179	0.015
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.015
bone morphogenesis	GO:0060349	78	0.015
response to radiation	GO:0009314	165	0.015
nucleobase containing small molecule metabolic process	GO:0055086	352	0.015
regulation of integrin mediated signaling pathway	GO:2001044	8	0.015
cell adhesion	GO:0007155	329	0.015
regulation of cell adhesion	GO:0030155	154	0.015
blood circulation	GO:0008015	195	0.015
response to lipopolysaccharide	GO:0032496	128	0.015
glycosyl compound catabolic process	GO:1901658	206	0.015
macromolecule catabolic process	GO:0009057	281	0.015
ear morphogenesis	GO:0042471	118	0.014
negative regulation of cellular protein metabolic process	GO:0032269	247	0.014
cellular chemical homeostasis	GO:0055082	215	0.014
ribonucleoside catabolic process	GO:0042454	206	0.014
asymmetric stem cell division	GO:0098722	3	0.014
regulation of establishment of protein localization	GO:0070201	181	0.014
sensory perception of sound	GO:0007605	97	0.014
cytoplasmic transport	GO:0016482	234	0.014
regulation of hydrolase activity	GO:0051336	246	0.014
negative regulation of gastrulation	GO:2000542	3	0.014
positive regulation of protein transport	GO:0051222	93	0.014
cellular response to organic cyclic compound	GO:0071407	87	0.014
notochord development	GO:0030903	20	0.014
hair follicle development	GO:0001942	85	0.014
ameboidal type cell migration	GO:0001667	128	0.014
nucleoside catabolic process	GO:0009164	206	0.014
monocarboxylic acid transport	GO:0015718	44	0.014
male gamete generation	GO:0048232	285	0.014
negative regulation of multi organism process	GO:0043901	68	0.014
regulation of neuron apoptotic process	GO:0043523	122	0.014
camera type eye development	GO:0043010	266	0.013
positive regulation of protein secretion	GO:0050714	52	0.013
spermatogenesis	GO:0007283	284	0.013
cell matrix adhesion	GO:0007160	68	0.013
ribonucleotide catabolic process	GO:0009261	208	0.013
response to organonitrogen compound	GO:0010243	246	0.013
lipid transport	GO:0006869	98	0.013
defense response to virus	GO:0051607	68	0.013
heterocycle catabolic process	GO:0046700	280	0.013
regulation of coagulation	GO:0050818	31	0.013
negative regulation of cell development	GO:0010721	169	0.013
phagocytosis	GO:0006909	66	0.013
lymphocyte differentiation	GO:0030098	242	0.013
peptide secretion	GO:0002790	114	0.013
defense response to other organism	GO:0098542	197	0.013
compound eye development	GO:0048749	1	0.013
wound healing	GO:0042060	157	0.013
divalent metal ion transport	GO:0070838	172	0.013
positive regulation of apoptotic process	GO:0043065	217	0.012
positive regulation of interleukin 8 production	GO:0032757	2	0.012
fibrinolysis	GO:0042730	3	0.012
cellular response to organonitrogen compound	GO:0071417	145	0.012
regulation of intracellular protein transport	GO:0033157	82	0.012
regulation of cell activation	GO:0050865	289	0.012
negative regulation of signal transduction in absence of ligand	GO:1901099	16	0.012
intracellular protein transport	GO:0006886	204	0.012
positive regulation of secretion	GO:0051047	130	0.012
carbohydrate derivative catabolic process	GO:1901136	231	0.012
long chain fatty acid import	GO:0044539	2	0.012
wnt signaling pathway	GO:0016055	188	0.012
positive regulation of cellular catabolic process	GO:0031331	148	0.012
negative regulation of phosphate metabolic process	GO:0045936	184	0.012
response to extracellular stimulus	GO:0009991	127	0.012
respiratory tube development	GO:0030323	167	0.012
positive regulation of neutrophil apoptotic process	GO:0033031	1	0.012
pallium development	GO:0021543	120	0.012
cellular homeostasis	GO:0019725	240	0.011
regulation of vesicle mediated transport	GO:0060627	139	0.011
purine ribonucleotide metabolic process	GO:0009150	290	0.011
negative regulation of ossification	GO:0030279	49	0.011
regulation of protein binding	GO:0043393	60	0.011
regulation of cellular ketone metabolic process	GO:0010565	66	0.011
transmembrane transport	GO:0055085	412	0.011
lateral line system development	GO:0048925	1	0.011
response to epidermal growth factor	GO:0070849	4	0.011
regulation of cell motility	GO:2000145	236	0.011
leukocyte apoptotic process	GO:0071887	71	0.011
smooth muscle tissue development	GO:0048745	22	0.011
regulation of protein maturation	GO:1903317	96	0.011
organism emergence from protective structure	GO:0071684	4	0.011
cardiac ventricle morphogenesis	GO:0003208	50	0.011
peripheral nervous system axon regeneration	GO:0014012	2	0.011
regulation of protein catabolic process	GO:0042176	108	0.011
regulation of epithelial cell migration	GO:0010632	35	0.011
dna conformation change	GO:0071103	37	0.011
mitotic cell cycle process	GO:1903047	159	0.011
membrane lipid biosynthetic process	GO:0046467	32	0.011
t cell mediated immunity	GO:0002456	50	0.011
neuromuscular process	GO:0050905	99	0.011
head morphogenesis	GO:0060323	34	0.011
multi multicellular organism process	GO:0044706	109	0.011
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.011
positive regulation of heart rate by epinephrine norepinephrine	GO:0001996	4	0.011
mitotic cell cycle	GO:0000278	195	0.010
positive regulation of vasoconstriction	GO:0045907	4	0.010
neuron migration	GO:0001764	122	0.010
gliogenesis	GO:0042063	141	0.010
skin development	GO:0043588	220	0.010
regulation of inflammatory response	GO:0050727	147	0.010
trabecula morphogenesis	GO:0061383	40	0.010
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.010
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.010
regulation of purine nucleotide metabolic process	GO:1900542	169	0.010
nucleoside triphosphate metabolic process	GO:0009141	230	0.010
dna topological change	GO:0006265	2	0.010
cardiac chamber development	GO:0003205	108	0.010
endodermal cell differentiation	GO:0035987	14	0.010

Ppic disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.309
connective tissue disease	DOID:65	0.309
disease of anatomical entity	DOID:7	0.309
bone development disease	DOID:0080006	0.302
bone disease	DOID:0080001	0.302
osteochondrodysplasia	DOID:2256	0.162
nervous system disease	DOID:863	0.028
charcot marie tooth disease	DOID:10595	0.028
neuromuscular disease	DOID:440	0.028
neuropathy	DOID:870	0.028
collagen disease	DOID:854	0.019
disease of metabolism	DOID:0014667	0.013
carbohydrate metabolic disorder	DOID:2978	0.013
inherited metabolic disorder	DOID:655	0.013
ehlers danlos syndrome	DOID:13359	0.012

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