| nucleoside triphosphate metabolic process | GO:0009141 | 230 | 0.842 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 133 | 0.581 | Yeast |
| proteasomal protein catabolic process | GO:0010498 | 98 | 0.469 | Yeast |
| proteasomal ubiquitin independent protein catabolic process | GO:0010499 | 1 | 0.453 | Yeast |
| spermatogenesis | GO:0007283 | 284 | 0.417 | |
| cellular protein catabolic process | GO:0044257 | 155 | 0.356 | Yeast |
| purine ribonucleoside metabolic process | GO:0046128 | 241 | 0.347 | |
| modification dependent protein catabolic process | GO:0019941 | 133 | 0.322 | Yeast |
| purine nucleotide metabolic process | GO:0006163 | 302 | 0.282 | |
| protein catabolic process | GO:0030163 | 221 | 0.275 | Yeast |
| ubiquitin dependent protein catabolic process | GO:0006511 | 129 | 0.243 | Yeast |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 88 | 0.241 | Yeast |
| cellular macromolecule catabolic process | GO:0044265 | 206 | 0.205 | Yeast |
| regulation of nucleoside metabolic process | GO:0009118 | 130 | 0.192 | |
| purine containing compound metabolic process | GO:0072521 | 311 | 0.187 | |
| male gamete generation | GO:0048232 | 285 | 0.182 | |
| proteasome assembly | GO:0043248 | 1 | 0.165 | |
| nucleoside phosphate metabolic process | GO:0006753 | 338 | 0.165 | |
| ribonucleoside metabolic process | GO:0009119 | 245 | 0.152 | |
| purine nucleoside triphosphate metabolic process | GO:0009144 | 226 | 0.151 | |
| nucleoside metabolic process | GO:0009116 | 246 | 0.148 | |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 147 | 0.145 | Yeast |
| atp metabolic process | GO:0046034 | 75 | 0.145 | |
| ribonucleotide metabolic process | GO:0009259 | 291 | 0.132 | |
| macromolecule catabolic process | GO:0009057 | 281 | 0.132 | Yeast |
| purine ribonucleotide metabolic process | GO:0009150 | 290 | 0.131 | |
| cytokine production | GO:0001816 | 319 | 0.124 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 352 | 0.121 | |
| purine ribonucleoside monophosphate metabolic process | GO:0009167 | 80 | 0.120 | |
| ribose phosphate metabolic process | GO:0019693 | 291 | 0.118 | |
| gonad development | GO:0008406 | 141 | 0.097 | |
| purine nucleoside metabolic process | GO:0042278 | 241 | 0.091 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 5 | 0.087 | |
| nucleotide metabolic process | GO:0009117 | 332 | 0.080 | |
| dopamine uptake involved in synaptic transmission | GO:0051583 | 4 | 0.080 | |
| purine ribonucleoside triphosphate metabolic process | GO:0009205 | 220 | 0.069 | |
| apoptotic signaling pathway | GO:0097190 | 306 | 0.062 | |
| cellular metal ion homeostasis | GO:0006875 | 151 | 0.061 | |
| transmembrane transport | GO:0055085 | 412 | 0.059 | |
| ribonucleoside triphosphate metabolic process | GO:0009199 | 220 | 0.059 | |
| cellular amino acid metabolic process | GO:0006520 | 103 | 0.058 | |
| dna metabolic process | GO:0006259 | 303 | 0.058 | |
| cellular response to dna damage stimulus | GO:0006974 | 207 | 0.057 | Fly |
| nucleoside phosphate catabolic process | GO:1901292 | 222 | 0.056 | |
| membrane organization | GO:0061024 | 245 | 0.053 | |
| nucleoside monophosphate metabolic process | GO:0009123 | 85 | 0.050 | |
| regulation of membrane potential | GO:0042391 | 192 | 0.049 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.049 | |
| regulation of nucleotide metabolic process | GO:0006140 | 169 | 0.046 | |
| regulation of defense response | GO:0031347 | 233 | 0.046 | |
| regulation of transferase activity | GO:0051338 | 263 | 0.045 | |
| cellular homeostasis | GO:0019725 | 240 | 0.045 | |
| metal ion homeostasis | GO:0055065 | 189 | 0.044 | |
| regulation of purine nucleotide metabolic process | GO:1900542 | 169 | 0.044 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 155 | 0.041 | |
| cellular chemical homeostasis | GO:0055082 | 215 | 0.041 | |
| amine metabolic process | GO:0009308 | 45 | 0.041 | |
| glycerolipid metabolic process | GO:0046486 | 122 | 0.040 | |
| carbohydrate derivative catabolic process | GO:1901136 | 231 | 0.039 | |
| development of primary sexual characteristics | GO:0045137 | 143 | 0.039 | |
| inorganic cation transmembrane transport | GO:0098662 | 207 | 0.039 | |
| ribonucleoside monophosphate metabolic process | GO:0009161 | 80 | 0.038 | |
| positive regulation of protein modification process | GO:0031401 | 299 | 0.037 | |
| cation transport | GO:0006812 | 399 | 0.036 | |
| cellular amine metabolic process | GO:0044106 | 44 | 0.036 | |
| response to organonitrogen compound | GO:0010243 | 246 | 0.034 | |
| organophosphate biosynthetic process | GO:0090407 | 122 | 0.034 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 5 | 0.033 | |
| heterocycle catabolic process | GO:0046700 | 280 | 0.033 | |
| glycosyl compound metabolic process | GO:1901657 | 246 | 0.032 | |
| response to oxidative stress | GO:0006979 | 123 | 0.032 | |
| phospholipid metabolic process | GO:0006644 | 87 | 0.032 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 66 | 0.032 | |
| nucleotide catabolic process | GO:0009166 | 217 | 0.031 | |
| organic cyclic compound catabolic process | GO:1901361 | 295 | 0.031 | |
| purine nucleotide catabolic process | GO:0006195 | 211 | 0.030 | |
| cation homeostasis | GO:0055080 | 212 | 0.030 | |
| t cell activation | GO:0042110 | 289 | 0.029 | |
| reactive oxygen species metabolic process | GO:0072593 | 84 | 0.029 | |
| engulfment of apoptotic cell | GO:0043652 | 3 | 0.029 | |
| regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway | GO:2001267 | 4 | 0.029 | |
| organophosphate catabolic process | GO:0046434 | 232 | 0.028 | |
| regulation of apoptotic signaling pathway | GO:2001233 | 197 | 0.028 | |
| cellular lipid metabolic process | GO:0044255 | 323 | 0.028 | |
| purine nucleoside monophosphate metabolic process | GO:0009126 | 81 | 0.027 | |
| regulation of cell activation | GO:0050865 | 289 | 0.026 | |
| peptidyl serine modification | GO:0018209 | 83 | 0.025 | |
| regulation of inflammatory response | GO:0050727 | 147 | 0.025 | |
| cation transmembrane transport | GO:0098655 | 266 | 0.025 | |
| regulation of monooxygenase activity | GO:0032768 | 7 | 0.025 | |
| inorganic ion transmembrane transport | GO:0098660 | 234 | 0.025 | |
| regulation of lymphocyte activation | GO:0051249 | 240 | 0.025 | |
| regulation of response to wounding | GO:1903034 | 189 | 0.025 | |
| cellular ion homeostasis | GO:0006873 | 165 | 0.025 | |
| cellular ketone metabolic process | GO:0042180 | 84 | 0.024 | |
| embryonic organ morphogenesis | GO:0048562 | 276 | 0.024 | |
| gland development | GO:0048732 | 330 | 0.024 | |
| regulation of t cell activation | GO:0050863 | 170 | 0.023 | |
| regulation of feeding behavior | GO:0060259 | 3 | 0.023 | |
| peptidyl amino acid modification | GO:0018193 | 336 | 0.022 | |
| ketone catabolic process | GO:0042182 | 3 | 0.022 | |
| germ cell development | GO:0007281 | 185 | 0.021 | |
| leukocyte differentiation | GO:0002521 | 342 | 0.020 | |
| positive regulation of nucleoside metabolic process | GO:0045979 | 91 | 0.020 | |
| mrna metabolic process | GO:0016071 | 84 | 0.020 | |
| inflammatory response | GO:0006954 | 244 | 0.020 | |
| cellular nitrogen compound catabolic process | GO:0044270 | 280 | 0.020 | |
| rna splicing | GO:0008380 | 54 | 0.019 | |
| protein modification by small protein conjugation | GO:0032446 | 187 | 0.019 | |
| carboxylic acid biosynthetic process | GO:0046394 | 86 | 0.019 | |
| regulation of mitochondrial membrane potential | GO:0051881 | 17 | 0.019 | |
| hydrogen transport | GO:0006818 | 35 | 0.018 | |
| lactate biosynthetic process | GO:0019249 | 4 | 0.018 | |
| ribonucleotide catabolic process | GO:0009261 | 208 | 0.018 | |
| nucleoside catabolic process | GO:0009164 | 206 | 0.018 | |
| regulation of lymphocyte differentiation | GO:0045619 | 107 | 0.018 | |
| peptidyl serine phosphorylation | GO:0018105 | 74 | 0.018 | |
| endomembrane system organization | GO:0010256 | 147 | 0.018 | |
| mitotic cell cycle | GO:0000278 | 195 | 0.018 | |
| extracellular structure organization | GO:0043062 | 148 | 0.018 | |
| mrna processing | GO:0006397 | 63 | 0.017 | |
| regulation of protein kinase activity | GO:0045859 | 232 | 0.017 | |
| cellular aldehyde metabolic process | GO:0006081 | 12 | 0.017 | |
| regulation of cellular amine metabolic process | GO:0033238 | 20 | 0.017 | |
| positive regulation of protein phosphorylation | GO:0001934 | 242 | 0.017 | |
| purine ribonucleotide catabolic process | GO:0009154 | 208 | 0.017 | |
| dna dealkylation | GO:0035510 | 11 | 0.017 | |
| negative regulation of cellular component organization | GO:0051129 | 194 | 0.017 | |
| defecation | GO:0030421 | 1 | 0.017 | |
| regulation of removal of superoxide radicals | GO:2000121 | 4 | 0.017 | |
| protein modification by small protein removal | GO:0070646 | 21 | 0.017 | |
| positive regulation of organelle organization | GO:0010638 | 128 | 0.017 | |
| protein processing | GO:0016485 | 163 | 0.016 | |
| microtubule cytoskeleton organization | GO:0000226 | 157 | 0.016 | |
| rna splicing via transesterification reactions with bulged adenosine as nucleophile | GO:0000377 | 43 | 0.016 | |
| regulation of generation of precursor metabolites and energy | GO:0043467 | 38 | 0.016 | |
| regulation of hydrolase activity | GO:0051336 | 246 | 0.016 | Yeast |
| positive regulation of proteolysis | GO:0045862 | 85 | 0.016 | Yeast |
| protein ubiquitination | GO:0016567 | 171 | 0.016 | |
| endocytosis | GO:0006897 | 168 | 0.016 | |
| regulation of organelle organization | GO:0033043 | 289 | 0.016 | |
| purine containing compound catabolic process | GO:0072523 | 213 | 0.016 | |
| organonitrogen compound catabolic process | GO:1901565 | 264 | 0.016 | |
| positive regulation of apoptotic process | GO:0043065 | 217 | 0.015 | |
| aromatic compound catabolic process | GO:0019439 | 286 | 0.015 | |
| cellular response to organonitrogen compound | GO:0071417 | 145 | 0.015 | |
| regulation of atp metabolic process | GO:1903578 | 17 | 0.015 | |
| mapk cascade | GO:0000165 | 281 | 0.015 | |
| sensory organ morphogenesis | GO:0090596 | 242 | 0.015 | |
| cellular response to peptide hormone stimulus | GO:0071375 | 92 | 0.015 | |
| purine nucleoside triphosphate catabolic process | GO:0009146 | 203 | 0.014 | |
| regulation of oxidative phosphorylation | GO:0002082 | 6 | 0.014 | |
| negative regulation of apoptotic signaling pathway | GO:2001234 | 104 | 0.014 | |
| manganese ion transport | GO:0006828 | 5 | 0.014 | |
| nucleoside triphosphate catabolic process | GO:0009143 | 205 | 0.014 | |
| immune response regulating signaling pathway | GO:0002764 | 125 | 0.014 | |
| organic hydroxy compound metabolic process | GO:1901615 | 203 | 0.014 | |
| reactive oxygen species biosynthetic process | GO:1903409 | 8 | 0.014 | |
| organelle fission | GO:0048285 | 170 | 0.014 | |
| extrinsic apoptotic signaling pathway | GO:0097191 | 126 | 0.013 | |
| alcohol metabolic process | GO:0006066 | 116 | 0.013 | |
| regulation of cell cycle process | GO:0010564 | 160 | 0.013 | |
| synaptic transmission | GO:0007268 | 329 | 0.013 | |
| intrinsic apoptotic signaling pathway | GO:0097193 | 132 | 0.013 | |
| positive regulation of purine nucleotide metabolic process | GO:1900544 | 114 | 0.013 | |
| regulation of lipid metabolic process | GO:0019216 | 118 | 0.013 | |
| regulation of cellular response to oxidative stress | GO:1900407 | 19 | 0.013 | |
| divalent inorganic cation homeostasis | GO:0072507 | 138 | 0.012 | |
| organic hydroxy compound biosynthetic process | GO:1901617 | 77 | 0.012 | |
| ribonucleoprotein complex subunit organization | GO:0071826 | 28 | 0.012 | |
| spindle organization | GO:0007051 | 28 | 0.012 | |
| regulation of mitochondrion organization | GO:0010821 | 27 | 0.012 | |
| response to hydrogen peroxide | GO:0042542 | 32 | 0.012 | |
| positive regulation of apoptotic signaling pathway | GO:2001235 | 95 | 0.012 | |
| cell growth | GO:0016049 | 130 | 0.012 | |
| protein oligomerization | GO:0051259 | 67 | 0.012 | |
| positive regulation of growth | GO:0045927 | 104 | 0.012 | |
| blastocyst development | GO:0001824 | 80 | 0.012 | |
| interleukin 8 production | GO:0032637 | 4 | 0.012 | |
| protein maturation | GO:0051604 | 176 | 0.012 | |
| regulation of cytokine production | GO:0001817 | 266 | 0.012 | |
| cellular transition metal ion homeostasis | GO:0046916 | 32 | 0.012 | |
| negative regulation of cell cycle | GO:0045786 | 123 | 0.012 | |
| carbohydrate derivative biosynthetic process | GO:1901137 | 183 | 0.012 | |
| leukocyte proliferation | GO:0070661 | 172 | 0.012 | |
| organic acid biosynthetic process | GO:0016053 | 86 | 0.012 | |
| positive regulation of nucleotide metabolic process | GO:0045981 | 114 | 0.012 | |
| multi multicellular organism process | GO:0044706 | 109 | 0.012 | |
| epithelial cell proliferation | GO:0050673 | 174 | 0.012 | |
| rna splicing via transesterification reactions | GO:0000375 | 43 | 0.012 | |
| cytokinetic process | GO:0032506 | 2 | 0.012 | |
| body morphogenesis | GO:0010171 | 45 | 0.011 | |
| regulation of ion transport | GO:0043269 | 215 | 0.011 | |
| positive regulation of intrinsic apoptotic signaling pathway | GO:2001244 | 25 | 0.011 | |
| maintenance of location | GO:0051235 | 89 | 0.011 | |
| lymphocyte differentiation | GO:0030098 | 242 | 0.011 | |
| protein localization to nucleus | GO:0034504 | 121 | 0.011 | |
| regulation of organ morphogenesis | GO:2000027 | 144 | 0.011 | |
| protein acylation | GO:0043543 | 64 | 0.011 | |
| smad protein signal transduction | GO:0060395 | 21 | 0.011 | |
| mitotic cell cycle process | GO:1903047 | 159 | 0.011 | |
| superoxide metabolic process | GO:0006801 | 27 | 0.011 | |
| negative regulation of molecular function | GO:0044092 | 258 | 0.010 | |
| antigen receptor mediated signaling pathway | GO:0050851 | 64 | 0.010 | |
| regulation of protein transport | GO:0051223 | 163 | 0.010 | |
| regulation of reactive oxygen species metabolic process | GO:2000377 | 40 | 0.010 | |
| multicellular organismal aging | GO:0010259 | 24 | 0.010 | |
| calcium ion homeostasis | GO:0055074 | 127 | 0.010 | |
| cellular divalent inorganic cation homeostasis | GO:0072503 | 127 | 0.010 | |
| myeloid cell differentiation | GO:0030099 | 233 | 0.010 | |
