IMP: Integrative Multi-species Prediction

Mus musculus

41 known processes

Srsf2

serine/arginine-rich splicing factor 2

(Aliases: MRF-1,SC35,Sfrs2,D11Wsu175e,Sfrs10,Pr264)

Ensembl: ENSMUSG00000034120
Entrez: 20382
UniProtKB: Q62093

Process Predictions
Disease Predictions

Srsf2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.953
mrna metabolic process	GO:0016071	84	0.831
mrna splicing via spliceosome	GO:0000398	43	0.821
rna processing	GO:0006396	105	0.770
nuclear division	GO:0000280	158	0.748	Worm
regulation of rna splicing	GO:0043484	37	0.730
mitotic cell cycle	GO:0000278	195	0.699
rna splicing	GO:0008380	54	0.693
mrna processing	GO:0006397	63	0.681
alternative mrna splicing via spliceosome	GO:0000380	12	0.646
oocyte anterior posterior axis specification	GO:0007314	2	0.599
regulation of mrna splicing via spliceosome	GO:0048024	32	0.570
mitotic cell cycle process	GO:1903047	159	0.540
rna transport	GO:0050658	18	0.449
organelle fission	GO:0048285	170	0.416	Worm
rna splicing via transesterification reactions	GO:0000375	43	0.402
oocyte construction	GO:0007308	2	0.371
regulation of mrna processing	GO:0050684	41	0.368
methylation	GO:0032259	134	0.360
germ cell development	GO:0007281	185	0.358
regulation of cell cycle process	GO:0010564	160	0.350	Worm
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.340
male meiosis i	GO:0007141	16	0.316
regulation of mrna stability	GO:0043488	23	0.309
positive regulation of rna splicing	GO:0033120	12	0.303
posttranscriptional regulation of gene expression	GO:0010608	155	0.293
male gamete generation	GO:0048232	285	0.286
pole plasm assembly	GO:0007315	2	0.280
negative regulation of mrna processing	GO:0050686	12	0.280
rna localization	GO:0006403	23	0.279
negative regulation of mrna splicing via spliceosome	GO:0048025	12	0.273
nucleic acid transport	GO:0050657	18	0.271
negative regulation of rna splicing	GO:0033119	12	0.251
regulation of mrna metabolic process	GO:1903311	43	0.243
oogenesis	GO:0048477	56	0.223
regulation of mitotic cell cycle	GO:0007346	126	0.216
establishment of rna localization	GO:0051236	18	0.211
meiotic nuclear division	GO:0007126	115	0.202	Worm
microtubule based process	GO:0007017	236	0.201
positive regulation of mrna splicing via spliceosome	GO:0048026	11	0.197
negative regulation of mrna metabolic process	GO:1903312	13	0.192
regulation of cell cycle	GO:0051726	281	0.191	Worm
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.189
regulation of alternative mrna splicing via spliceosome	GO:0000381	8	0.189
compound eye development	GO:0048749	1	0.188
intracellular mrna localization	GO:0008298	4	0.176
microtubule cytoskeleton organization	GO:0000226	157	0.166
spermatogenesis	GO:0007283	284	0.153
oocyte axis specification	GO:0007309	2	0.149
nuclear export	GO:0051168	34	0.146
regulation of organelle organization	GO:0033043	289	0.146	Worm
cellular response to dna damage stimulus	GO:0006974	207	0.144
regionalization	GO:0003002	337	0.139
positive regulation of mitotic cell cycle phase transition	GO:1901992	17	0.139
translation	GO:0006412	93	0.139
segmentation	GO:0035282	93	0.122
negative regulation of cellular component organization	GO:0051129	194	0.117
positive regulation of cell cycle process	GO:0090068	61	0.115
adult locomotory behavior	GO:0008344	91	0.113
nitrogen compound transport	GO:0071705	271	0.108
nucleocytoplasmic transport	GO:0006913	139	0.106
cytoplasmic transport	GO:0016482	234	0.104
female gamete generation	GO:0007292	74	0.103
protein methylation	GO:0006479	81	0.101
positive regulation of mrna metabolic process	GO:1903313	17	0.100
posttranscriptional gene silencing by rna	GO:0035194	10	0.098
positive regulation of mrna processing	GO:0050685	16	0.097
rna interference	GO:0016246	2	0.095
protein complex disassembly	GO:0043241	40	0.095
negative regulation of dna templated transcription termination	GO:0060567	1	0.093
ossification	GO:0001503	216	0.086
regulation of translation	GO:0006417	71	0.085
adult behavior	GO:0030534	135	0.085
spermatid differentiation	GO:0048515	115	0.085
mitotic nuclear division	GO:0007067	48	0.081
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.081
gene silencing	GO:0016458	38	0.080
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.072
regulation of cellular component biogenesis	GO:0044087	181	0.072
regulation of rna stability	GO:0043487	26	0.072
male meiosis	GO:0007140	37	0.068
organonitrogen compound biosynthetic process	GO:1901566	192	0.067
positive regulation of dna templated transcription elongation	GO:0032786	2	0.064
dna repair	GO:0006281	107	0.064
gonad development	GO:0008406	141	0.063
oocyte development	GO:0048599	33	0.062
cellular response to cytokine stimulus	GO:0071345	189	0.061
nls bearing protein import into nucleus	GO:0006607	2	0.061
positive regulation of translation	GO:0045727	19	0.060
negative regulation of cell cycle	GO:0045786	123	0.060
regulation of cell division	GO:0051302	76	0.060	Worm
skin development	GO:0043588	220	0.059
negative regulation of keratinocyte differentiation	GO:0045617	4	0.059
protein desumoylation	GO:0016926	2	0.057
locomotory behavior	GO:0007626	195	0.054
dna templated transcription termination	GO:0006353	4	0.054
regulation of binding	GO:0051098	111	0.054
apoptotic signaling pathway	GO:0097190	306	0.054
positive regulation of cell cycle	GO:0045787	92	0.052
regulation of nuclear division	GO:0051783	56	0.051	Worm
spliceosomal complex assembly	GO:0000245	6	0.050
regulation of apoptotic signaling pathway	GO:2001233	197	0.050
ribonucleoprotein complex subunit organization	GO:0071826	28	0.049
spermatid development	GO:0007286	108	0.049
nucleobase containing compound transport	GO:0015931	27	0.049
protein import into nucleus	GO:0006606	95	0.047
oocyte differentiation	GO:0009994	35	0.047
transcription coupled nucleotide excision repair	GO:0006283	2	0.047
oxidation reduction process	GO:0055114	342	0.047
mrna catabolic process	GO:0006402	22	0.046
regulation of cell cycle phase transition	GO:1901987	77	0.046
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.045
ribonucleoprotein complex localization	GO:0071166	1	0.045
positive regulation of organelle organization	GO:0010638	128	0.045
3 utr mediated mrna stabilization	GO:0070935	2	0.045
stem cell differentiation	GO:0048863	268	0.044
negative regulation of protein metabolic process	GO:0051248	282	0.044
cell fate specification	GO:0001708	72	0.043
macromolecule methylation	GO:0043414	120	0.041
nuclear transcribed mrna catabolic process	GO:0000956	16	0.040
ribonucleoprotein complex disassembly	GO:0032988	3	0.040
stem cell development	GO:0048864	219	0.040
regulation of circadian rhythm	GO:0042752	58	0.040
hematopoietic progenitor cell differentiation	GO:0002244	143	0.039
lung development	GO:0030324	164	0.039
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.038
meiotic cell cycle	GO:0051321	122	0.038	Worm
protein alkylation	GO:0008213	81	0.036
nuclear transport	GO:0051169	139	0.036
dna metabolic process	GO:0006259	303	0.036
mrna stabilization	GO:0048255	9	0.036
maternal process involved in female pregnancy	GO:0060135	32	0.035
amine metabolic process	GO:0009308	45	0.035
negative regulation of cellular protein metabolic process	GO:0032269	247	0.035
dna dependent dna replication maintenance of fidelity	GO:0045005	3	0.035
positive regulation of programmed cell death	GO:0043068	218	0.034
centrosome separation	GO:0051299	4	0.034
mrna localization resulting in posttranscriptional regulation of gene expression	GO:0010609	2	0.034
regulation of keratinocyte proliferation	GO:0010837	15	0.034
striated muscle contraction	GO:0006941	45	0.033
regulation of glycogen catabolic process	GO:0005981	2	0.033
gene silencing by rna	GO:0031047	19	0.033
positive regulation of cell cycle phase transition	GO:1901989	17	0.032
small molecule biosynthetic process	GO:0044283	132	0.032
ras protein signal transduction	GO:0007265	77	0.031
maternal placenta development	GO:0001893	20	0.031
dna templated transcription elongation	GO:0006354	13	0.031
hexose metabolic process	GO:0019318	98	0.031
rna 3 end processing	GO:0031123	20	0.031
epidermis development	GO:0008544	187	0.030
cellular amine metabolic process	GO:0044106	44	0.030
carbohydrate derivative biosynthetic process	GO:1901137	183	0.030
inflammatory response	GO:0006954	244	0.029
cellular macromolecule catabolic process	GO:0044265	206	0.029
nucleus organization	GO:0006997	45	0.028
skeletal system development	GO:0001501	356	0.028
modification dependent macromolecule catabolic process	GO:0043632	133	0.028
cell maturation	GO:0048469	127	0.027
stem cell maintenance	GO:0019827	130	0.027
cellular amino acid metabolic process	GO:0006520	103	0.027
embryonic skeletal system development	GO:0048706	120	0.027
sensory perception	GO:0007600	245	0.026
regulation of protein complex assembly	GO:0043254	83	0.026
positive regulation of cell death	GO:0010942	224	0.025
placenta development	GO:0001890	140	0.025
rna stabilization	GO:0043489	9	0.025
circulatory system process	GO:0003013	197	0.025
regulation of intracellular transport	GO:0032386	159	0.024
positive regulation of mitotic cell cycle	GO:0045931	41	0.024
response to lipopolysaccharide	GO:0032496	128	0.024
dna integrity checkpoint	GO:0031570	28	0.024
intrinsic apoptotic signaling pathway	GO:0097193	132	0.024
regulation of proteolysis	GO:0030162	164	0.023
regulation of lymphocyte activation	GO:0051249	240	0.023
positive regulation of apoptotic process	GO:0043065	217	0.023
pharynx development	GO:0060465	1	0.023
regulation of dna templated transcription termination	GO:0031554	1	0.023
negative regulation of translation	GO:0017148	22	0.023
organophosphate biosynthetic process	GO:0090407	122	0.023
germ cell proliferation	GO:0036093	7	0.022
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.022
epithelial to mesenchymal transition	GO:0001837	47	0.022
histone methylation	GO:0016571	71	0.022
protein localization to organelle	GO:0033365	185	0.022
nuclear import	GO:0051170	95	0.022
mrna export from nucleus	GO:0006406	11	0.022
mrna transport	GO:0051028	13	0.022
wound healing	GO:0042060	157	0.022
dna recombination	GO:0006310	92	0.022
epithelial cell proliferation	GO:0050673	174	0.021
axon target recognition	GO:0007412	4	0.021
regulation of transferase activity	GO:0051338	263	0.021
negative regulation of molecular function	GO:0044092	258	0.021
embryonic axis specification	GO:0000578	30	0.021
regulation of microtubule based process	GO:0032886	52	0.021
lipid biosynthetic process	GO:0008610	179	0.020
peptidyl amino acid modification	GO:0018193	336	0.020
response to oxidative stress	GO:0006979	123	0.020
blood vessel morphogenesis	GO:0048514	285	0.020
spindle organization	GO:0007051	28	0.020
heart morphogenesis	GO:0003007	178	0.020
response to organic cyclic compound	GO:0014070	198	0.020
multi multicellular organism process	GO:0044706	109	0.020
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.020
circadian rhythm	GO:0007623	114	0.020
transcription elongation from rna polymerase ii promoter	GO:0006368	9	0.020
cell cycle checkpoint	GO:0000075	47	0.020
chromatin modification	GO:0016568	187	0.020
regulation of protein localization	GO:0032880	231	0.019
termination of rna polymerase ii transcription	GO:0006369	1	0.019
cellular protein complex assembly	GO:0043623	116	0.019
regulation of cell activation	GO:0050865	289	0.019
regulation of cellular response to stress	GO:0080135	159	0.019
meiotic cell cycle process	GO:1903046	77	0.019
negative regulation of apoptotic cell clearance	GO:2000426	1	0.019
fatty acid biosynthetic process	GO:0006633	41	0.019
single organism nuclear import	GO:1902593	95	0.019
positive regulation of transcription from rna polymerase i promoter	GO:0045943	3	0.018
leukocyte proliferation	GO:0070661	172	0.018
transmembrane transport	GO:0055085	412	0.018
development of primary sexual characteristics	GO:0045137	143	0.018
regulation of protein catabolic process	GO:0042176	108	0.018
nuclear mrna surveillance	GO:0071028	1	0.017
regulation of cytoskeleton organization	GO:0051493	122	0.017
g1 s transition of mitotic cell cycle	GO:0000082	57	0.017
protein targeting	GO:0006605	143	0.017
body morphogenesis	GO:0010171	45	0.017	Worm
cellular protein complex disassembly	GO:0043624	36	0.017
purine nucleotide catabolic process	GO:0006195	211	0.017
positive regulation of nervous system development	GO:0051962	221	0.017
positive regulation of proteolysis	GO:0045862	85	0.017
cartilage development	GO:0051216	140	0.016
developmental maturation	GO:0021700	193	0.016
development of primary male sexual characteristics	GO:0046546	88	0.016
response to interferon gamma	GO:0034341	34	0.016
macromolecule catabolic process	GO:0009057	281	0.016
negative regulation of protein complex disassembly	GO:0043242	22	0.016
histone modification	GO:0016570	159	0.016
metaphase plate congression	GO:0051310	2	0.016
heterocycle catabolic process	GO:0046700	280	0.016
mesenchymal cell differentiation	GO:0048762	107	0.016
epithelial cell proliferation involved in lung morphogenesis	GO:0060502	5	0.016
skeletal system morphogenesis	GO:0048705	203	0.016
respiratory system development	GO:0060541	190	0.016
negative regulation of cell cycle process	GO:0010948	69	0.016
molting cycle	GO:0042303	90	0.015
cellular response to organic cyclic compound	GO:0071407	87	0.015
regulation of g1 s transition of mitotic cell cycle	GO:2000045	35	0.015
regulation of response to dna damage stimulus	GO:2001020	34	0.015
cardiac muscle contraction	GO:0060048	32	0.015
carboxylic acid biosynthetic process	GO:0046394	86	0.015
regulation of epithelial cell proliferation	GO:0050678	141	0.015
lung morphogenesis	GO:0060425	50	0.015
regulation of cellular catabolic process	GO:0031329	242	0.015
glycosyl compound biosynthetic process	GO:1901659	21	0.015
mrna splice site selection	GO:0006376	5	0.015
neuroblast differentiation	GO:0014016	2	0.014
response to molecule of bacterial origin	GO:0002237	143	0.014
innate immune response	GO:0045087	157	0.014
establishment of organelle localization	GO:0051656	122	0.014
connective tissue development	GO:0061448	179	0.014
aromatic compound catabolic process	GO:0019439	286	0.014
negative regulation of phagocytosis	GO:0050765	4	0.014
cellularization	GO:0007349	1	0.014
cellular lipid metabolic process	GO:0044255	323	0.014
regulation of reproductive process	GO:2000241	66	0.014
angiogenesis	GO:0001525	201	0.014
urogenital system development	GO:0001655	261	0.014
positive regulation of protein modification process	GO:0031401	299	0.014
blood circulation	GO:0008015	195	0.013
polyamine biosynthetic process	GO:0006596	2	0.013
histone h3 k4 methylation	GO:0051568	23	0.013
positive regulation of cellular amine metabolic process	GO:0033240	5	0.013
negative regulation of cell development	GO:0010721	169	0.013
regulation of protein complex disassembly	GO:0043244	28	0.013
positive regulation of lymphocyte activation	GO:0051251	140	0.013
muscle system process	GO:0003012	141	0.013
ribonucleoside biosynthetic process	GO:0042455	21	0.013
cell division	GO:0051301	120	0.013	Worm
intracellular protein transport	GO:0006886	204	0.013
cellular response to lipid	GO:0071396	145	0.013
fatty acid metabolic process	GO:0006631	121	0.012
negative regulation of dna replication	GO:0008156	4	0.012
positive regulation of glycogen catabolic process	GO:0045819	2	0.012
regulation of organ morphogenesis	GO:2000027	144	0.012
nucleotide excision repair	GO:0006289	13	0.012
glucan metabolic process	GO:0044042	32	0.012
leukocyte differentiation	GO:0002521	342	0.012
carbohydrate metabolic process	GO:0005975	230	0.012
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.012
regulation of multi organism process	GO:0043900	111	0.012
negative regulation of neuron projection regeneration	GO:0070571	3	0.012
rna dependent dna replication	GO:0006278	3	0.012
cellular protein catabolic process	GO:0044257	155	0.012
respiratory tube development	GO:0030323	167	0.012
humoral immune response	GO:0006959	57	0.012
organic acid biosynthetic process	GO:0016053	86	0.012
rrna containing ribonucleoprotein complex export from nucleus	GO:0071428	1	0.012
positive regulation of multi organism process	GO:0043902	26	0.011
response to temperature stimulus	GO:0009266	55	0.011
b cell activation	GO:0042113	161	0.011
epithelial tube morphogenesis	GO:0060562	303	0.011
protein localization to chromosome centromeric region	GO:0071459	1	0.011
mesenchyme development	GO:0060485	152	0.011
regulation of nucleotide metabolic process	GO:0006140	169	0.011
negative regulation of dna dependent dna replication	GO:2000104	1	0.011
visual perception	GO:0007601	52	0.011
embryonic organ morphogenesis	GO:0048562	276	0.011
regulation of keratinocyte differentiation	GO:0045616	11	0.011
positive regulation of reproductive process	GO:2000243	19	0.011
regulation of carbohydrate metabolic process	GO:0006109	75	0.011
tripartite regional subdivision	GO:0007351	9	0.011
negative regulation of mitotic cell cycle	GO:0045930	58	0.011
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.011
cellular ketone metabolic process	GO:0042180	84	0.011
morphogenesis of embryonic epithelium	GO:0016331	159	0.010
epithelial cell proliferation involved in prostate gland development	GO:0060767	11	0.010
rna catabolic process	GO:0006401	29	0.010
digestive tract morphogenesis	GO:0048546	147	0.010
cellular polysaccharide metabolic process	GO:0044264	38	0.010
regulation of endopeptidase activity	GO:0052548	89	0.010
regulation of response to wounding	GO:1903034	189	0.010
regulation of b cell activation	GO:0050864	81	0.010
cellular response to hormone stimulus	GO:0032870	150	0.010
organonitrogen compound catabolic process	GO:1901565	264	0.010
heart contraction	GO:0060047	93	0.010

Srsf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
central nervous system disease	DOID:331	0.062
disease of anatomical entity	DOID:7	0.062
nervous system disease	DOID:863	0.062
neurodegenerative disease	DOID:1289	0.023
myopathy	DOID:423	0.018
muscle tissue disease	DOID:66	0.018
muscular disease	DOID:0080000	0.018
musculoskeletal system disease	DOID:17	0.018

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