IMP: Integrative Multi-species Prediction

Mus musculus

15 known processes

Upf2

UPF2 regulator of nonsense transcripts homolog (yeast)

Entrez: 326622
Ensembl: ENSMUSG00000043241
UniProtKB: A2AT37

Process Predictions
Disease Predictions

Upf2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
chromatin organization	GO:0006325	206	0.145
cellular nitrogen compound catabolic process	GO:0044270	280	0.073
chromatin modification	GO:0016568	187	0.067
covalent chromatin modification	GO:0016569	163	0.061
heterocycle catabolic process	GO:0046700	280	0.057
mitotic cell cycle	GO:0000278	195	0.056
organelle fission	GO:0048285	170	0.055
histone modification	GO:0016570	159	0.054
regulation of cellular ketone metabolic process	GO:0010565	66	0.048
protein modification by small protein conjugation or removal	GO:0070647	207	0.047
mitotic cell cycle process	GO:1903047	159	0.047
nucleoside catabolic process	GO:0009164	206	0.045
purine containing compound metabolic process	GO:0072521	311	0.043
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.043
glycosyl compound metabolic process	GO:1901657	246	0.041
cell type specific apoptotic process	GO:0097285	268	0.041
regulation of cell cycle	GO:0051726	281	0.040
ribose phosphate metabolic process	GO:0019693	291	0.040
organic cyclic compound catabolic process	GO:1901361	295	0.039
myeloid cell differentiation	GO:0030099	233	0.039
apoptotic signaling pathway	GO:0097190	306	0.039
cellular response to dna damage stimulus	GO:0006974	207	0.039
axonogenesis	GO:0007409	274	0.038
nucleotide catabolic process	GO:0009166	217	0.037
nuclear division	GO:0000280	158	0.036
nucleotide metabolic process	GO:0009117	332	0.036
posttranscriptional regulation of gene expression	GO:0010608	155	0.035
purine ribonucleoside metabolic process	GO:0046128	241	0.035
blood vessel morphogenesis	GO:0048514	285	0.035
regulation of cell migration	GO:0030334	219	0.035
cellular ketone metabolic process	GO:0042180	84	0.034
nucleoside metabolic process	GO:0009116	246	0.034
aromatic compound catabolic process	GO:0019439	286	0.033
protein localization to organelle	GO:0033365	185	0.033
protein localization to nucleus	GO:0034504	121	0.033
regulation of organelle organization	GO:0033043	289	0.032
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.032
regulation of mitotic cell cycle	GO:0007346	126	0.031
protein maturation	GO:0051604	176	0.031
regulation of protein stability	GO:0031647	52	0.030
chemotaxis	GO:0006935	247	0.030
histone lysine methylation	GO:0034968	50	0.029
purine nucleoside metabolic process	GO:0042278	241	0.029
cellular response to lipid	GO:0071396	145	0.029
cellular amine metabolic process	GO:0044106	44	0.029
nucleoside phosphate metabolic process	GO:0006753	338	0.028
neural precursor cell proliferation	GO:0061351	121	0.028
establishment of protein localization to organelle	GO:0072594	118	0.028
negative regulation of cellular component organization	GO:0051129	194	0.028
cellular macromolecule catabolic process	GO:0044265	206	0.028
macromolecule methylation	GO:0043414	120	0.027
homeostasis of number of cells	GO:0048872	210	0.027
rna processing	GO:0006396	105	0.026
sodium ion transport	GO:0006814	73	0.026
organonitrogen compound catabolic process	GO:1901565	264	0.026
protein processing	GO:0016485	163	0.026
purine nucleotide catabolic process	GO:0006195	211	0.025
protein modification by small protein removal	GO:0070646	21	0.025
protein targeting	GO:0006605	143	0.025
microtubule cytoskeleton organization	GO:0000226	157	0.025
regulation of cell cycle process	GO:0010564	160	0.025
regulation of proteolysis	GO:0030162	164	0.025
purine containing compound catabolic process	GO:0072523	213	0.024
skeletal system development	GO:0001501	356	0.024
nucleoside triphosphate catabolic process	GO:0009143	205	0.024
cell division	GO:0051301	120	0.024
response to organic cyclic compound	GO:0014070	198	0.024
positive regulation of cellular amine metabolic process	GO:0033240	5	0.024
negative regulation of protein metabolic process	GO:0051248	282	0.024
regulation of hydrolase activity	GO:0051336	246	0.024
carboxylic acid biosynthetic process	GO:0046394	86	0.024
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.024
response to growth factor	GO:0070848	198	0.023
male gamete generation	GO:0048232	285	0.023
organophosphate catabolic process	GO:0046434	232	0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.023
negative regulation of organelle organization	GO:0010639	90	0.023
modification dependent macromolecule catabolic process	GO:0043632	133	0.023
regulation of peptidase activity	GO:0052547	96	0.023
protein modification by small protein conjugation	GO:0032446	187	0.023
negative regulation of molecular function	GO:0044092	258	0.023
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.023
defense response to other organism	GO:0098542	197	0.022
blood circulation	GO:0008015	195	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.022
purine nucleoside catabolic process	GO:0006152	205	0.022
purine ribonucleotide catabolic process	GO:0009154	208	0.022
regionalization	GO:0003002	337	0.022
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.021
methylation	GO:0032259	134	0.021
protein ubiquitination	GO:0016567	171	0.021
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.021
nuclear import	GO:0051170	95	0.021
sensory organ morphogenesis	GO:0090596	242	0.021
compound eye development	GO:0048749	1	0.021
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.021
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.020
regulation of chromatin silencing	GO:0031935	2	0.020
regulation of cellular amine metabolic process	GO:0033238	20	0.020
negative regulation of cell cycle	GO:0045786	123	0.020
microtubule based process	GO:0007017	236	0.020
regulation of cellular amino acid metabolic process	GO:0006521	5	0.020
purine ribonucleotide metabolic process	GO:0009150	290	0.020
ribonucleotide catabolic process	GO:0009261	208	0.020
adult behavior	GO:0030534	135	0.020
proteasomal protein catabolic process	GO:0010498	98	0.019
stem cell maintenance	GO:0019827	130	0.019
ion transmembrane transport	GO:0034220	361	0.019
purine nucleotide metabolic process	GO:0006163	302	0.019
ossification	GO:0001503	216	0.019
carbohydrate derivative catabolic process	GO:1901136	231	0.019
germ cell development	GO:0007281	185	0.019
positive regulation of hydrolase activity	GO:0051345	148	0.019
organic acid biosynthetic process	GO:0016053	86	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.018
purine ribonucleoside catabolic process	GO:0046130	205	0.018
dna repair	GO:0006281	107	0.018
striated muscle tissue development	GO:0014706	293	0.018
anatomical structure homeostasis	GO:0060249	145	0.018
cellular response to cytokine stimulus	GO:0071345	189	0.018
sensory perception	GO:0007600	245	0.018
regulation of cellular catabolic process	GO:0031329	242	0.018
heart morphogenesis	GO:0003007	178	0.018
demethylation	GO:0070988	23	0.018
transmembrane transport	GO:0055085	412	0.018
intracellular protein transport	GO:0006886	204	0.018
ribonucleotide metabolic process	GO:0009259	291	0.018
regulation of secretion	GO:0051046	274	0.018
stem cell proliferation	GO:0072089	117	0.018
forebrain development	GO:0030900	302	0.017
defense response to bacterium	GO:0042742	119	0.017
regulation of endopeptidase activity	GO:0052548	89	0.017
cation transport	GO:0006812	399	0.017
glycosyl compound catabolic process	GO:1901658	206	0.017
positive regulation of programmed cell death	GO:0043068	218	0.017
gene silencing	GO:0016458	38	0.017
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.017
stem cell development	GO:0048864	219	0.017
cellular response to organic cyclic compound	GO:0071407	87	0.017
positive regulation of cell death	GO:0010942	224	0.017
negative regulation of phosphorus metabolic process	GO:0010563	184	0.017
wnt signaling pathway	GO:0016055	188	0.017
skeletal system morphogenesis	GO:0048705	203	0.017
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.017
cellular response to abiotic stimulus	GO:0071214	56	0.016
carbohydrate derivative biosynthetic process	GO:1901137	183	0.016
positive regulation of protein phosphorylation	GO:0001934	242	0.016
female sex differentiation	GO:0046660	84	0.016
meiotic cell cycle	GO:0051321	122	0.016
morphogenesis of embryonic epithelium	GO:0016331	159	0.016
camera type eye development	GO:0043010	266	0.016
immune effector process	GO:0002252	321	0.016
regulation of cell cycle checkpoint	GO:1901976	9	0.016
nucleoside phosphate catabolic process	GO:1901292	222	0.016
organic hydroxy compound metabolic process	GO:1901615	203	0.016
epithelial tube morphogenesis	GO:0060562	303	0.016
dna metabolic process	GO:0006259	303	0.016
positive regulation of apoptotic process	GO:0043065	217	0.016
negative regulation of intracellular signal transduction	GO:1902532	167	0.016
epithelial cell proliferation	GO:0050673	174	0.015
peptidyl amino acid modification	GO:0018193	336	0.015
protein polyubiquitination	GO:0000209	33	0.015
nucleocytoplasmic transport	GO:0006913	139	0.015
cellular response to growth factor stimulus	GO:0071363	197	0.015
endomembrane system organization	GO:0010256	147	0.015
response to light stimulus	GO:0009416	135	0.015
divalent metal ion transport	GO:0070838	172	0.015
skeletal muscle organ development	GO:0060538	163	0.015
regulation of ion transport	GO:0043269	215	0.015
ear development	GO:0043583	200	0.015
positive regulation of cell development	GO:0010720	237	0.015
cellular amino acid metabolic process	GO:0006520	103	0.015
regulation of hormone levels	GO:0010817	211	0.015
mitotic nuclear division	GO:0007067	48	0.015
retina development in camera type eye	GO:0060041	119	0.015
negative regulation of protein modification process	GO:0031400	163	0.015
protein deubiquitination	GO:0016579	19	0.015
leukocyte apoptotic process	GO:0071887	71	0.015
negative regulation of protein processing	GO:0010955	79	0.015
ubiquitin dependent protein catabolic process	GO:0006511	129	0.014
regulation of t cell activation	GO:0050863	170	0.014
regulation of epithelial cell proliferation	GO:0050678	141	0.014
angiogenesis	GO:0001525	201	0.014
cellular response to nutrient levels	GO:0031669	64	0.014
histone h3 k9 methylation	GO:0051567	17	0.014
bmp signaling pathway	GO:0030509	93	0.014
regulation of apoptotic signaling pathway	GO:2001233	197	0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.014
regulation of cytoplasmic transport	GO:1903649	112	0.014
innate immune response	GO:0045087	157	0.014
amine metabolic process	GO:0009308	45	0.014
histone h3 k9 acetylation	GO:0043970	5	0.014
histone demethylation	GO:0016577	13	0.014
regulation of protein localization	GO:0032880	231	0.014
protein import into nucleus	GO:0006606	95	0.014
response to testosterone	GO:0033574	3	0.014
muscle tissue development	GO:0060537	308	0.014
regulation of histone h3 k9 methylation	GO:0051570	8	0.014
mrna metabolic process	GO:0016071	84	0.014
telencephalon development	GO:0021537	186	0.014
negative regulation of cell cycle process	GO:0010948	69	0.014
cell cycle checkpoint	GO:0000075	47	0.013
negative regulation of mitotic cell cycle	GO:0045930	58	0.013
negative regulation of cell cycle phase transition	GO:1901988	48	0.013
regulation of protein serine threonine kinase activity	GO:0071900	157	0.013
stem cell differentiation	GO:0048863	268	0.013
single organism nuclear import	GO:1902593	95	0.013
regulation of cellular response to stress	GO:0080135	159	0.013
sensory perception of sound	GO:0007605	97	0.013
ribonucleoside catabolic process	GO:0042454	206	0.013
intrinsic apoptotic signaling pathway	GO:0097193	132	0.013
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.013
regulation of secretion by cell	GO:1903530	249	0.013
histone methylation	GO:0016571	71	0.013
retinal blood vessel morphogenesis	GO:0061304	3	0.013
organelle localization	GO:0051640	179	0.013
neuron migration	GO:0001764	122	0.013
negative regulation of cellular protein metabolic process	GO:0032269	247	0.013
nitrogen compound transport	GO:0071705	271	0.013
fatty acid metabolic process	GO:0006631	121	0.013
spermatogenesis	GO:0007283	284	0.013
cellular response to hormone stimulus	GO:0032870	150	0.013
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.013
sensory perception of mechanical stimulus	GO:0050954	107	0.013
negative regulation of cell development	GO:0010721	169	0.013
regulation of membrane potential	GO:0042391	192	0.013
regulation of cell cycle phase transition	GO:1901987	77	0.013
atp catabolic process	GO:0006200	55	0.013
response to transforming growth factor beta	GO:0071559	88	0.013
ras protein signal transduction	GO:0007265	77	0.013
positive regulation of proteolysis	GO:0045862	85	0.012
regulation of cell growth	GO:0001558	91	0.012
glycoprotein metabolic process	GO:0009100	116	0.012
nucleobase containing small molecule metabolic process	GO:0055086	352	0.012
cellular response to organonitrogen compound	GO:0071417	145	0.012
multicellular organismal signaling	GO:0035637	91	0.012
palate development	GO:0060021	76	0.012
regulation of protein transport	GO:0051223	163	0.012
cytoplasmic transport	GO:0016482	234	0.012
regulation of lymphocyte differentiation	GO:0045619	107	0.012
dna conformation change	GO:0071103	37	0.012
regulation of cytokine production	GO:0001817	266	0.012
cation transmembrane transport	GO:0098655	266	0.012
regulation of intracellular transport	GO:0032386	159	0.012
cation homeostasis	GO:0055080	212	0.012
regulation of cell division	GO:0051302	76	0.012
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.012
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.012
regulation of t cell differentiation	GO:0045580	83	0.012
cell growth	GO:0016049	130	0.012
embryonic organ morphogenesis	GO:0048562	276	0.012
lipid localization	GO:0010876	126	0.012
nucleoside monophosphate catabolic process	GO:0009125	59	0.012
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.012
myeloid cell homeostasis	GO:0002262	114	0.012
inorganic ion transmembrane transport	GO:0098660	234	0.012
negative regulation of chromosome organization	GO:2001251	30	0.012
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.012
histone lysine demethylation	GO:0070076	13	0.012
maintenance of location	GO:0051235	89	0.012
intracellular receptor signaling pathway	GO:0030522	74	0.012
neuronal action potential	GO:0019228	54	0.012
regulation of response to alcohol	GO:1901419	2	0.012
regulation of fatty acid biosynthetic process	GO:0042304	12	0.012
response to lipopolysaccharide	GO:0032496	128	0.011
developmental maturation	GO:0021700	193	0.011
regulation of purine nucleotide catabolic process	GO:0033121	122	0.011
macromolecule catabolic process	GO:0009057	281	0.011
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.011
response to radiation	GO:0009314	165	0.011
dna recombination	GO:0006310	92	0.011
calcium ion homeostasis	GO:0055074	127	0.011
action potential	GO:0001508	78	0.011
regulation of leukocyte apoptotic process	GO:2000106	56	0.011
regulation of chromosome organization	GO:0033044	83	0.011
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.011
digestive tract morphogenesis	GO:0048546	147	0.011
inorganic cation transmembrane transport	GO:0098662	207	0.011
protein homotrimerization	GO:0070207	4	0.011
protein catabolic process	GO:0030163	221	0.011
protein methylation	GO:0006479	81	0.011
development of primary sexual characteristics	GO:0045137	143	0.011
positive regulation of protein modification process	GO:0031401	299	0.011
negative regulation of cell fate specification	GO:0009996	4	0.011
t cell activation	GO:0042110	289	0.011
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.011
b cell activation	GO:0042113	161	0.011
oocyte axis specification	GO:0007309	2	0.011
alpha beta t cell activation	GO:0046631	91	0.011
regulation of cell projection organization	GO:0031344	206	0.011
ear morphogenesis	GO:0042471	118	0.011
positive regulation of histone h3 k9 methylation	GO:0051574	4	0.011
cilium morphogenesis	GO:0060271	102	0.011
regulation of cellular component biogenesis	GO:0044087	181	0.011
regulation of stem cell proliferation	GO:0072091	78	0.011
response to oxidative stress	GO:0006979	123	0.011
cellular response to extracellular stimulus	GO:0031668	81	0.011
muscle contraction	GO:0006936	101	0.010
cell maturation	GO:0048469	127	0.010
negative regulation of t helper 2 cell differentiation	GO:0045629	4	0.010
small gtpase mediated signal transduction	GO:0007264	97	0.010
regulation of neuron differentiation	GO:0045664	281	0.010
cellular homeostasis	GO:0019725	240	0.010
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.010
regulation of ion transmembrane transport	GO:0034765	119	0.010
cardiac muscle tissue development	GO:0048738	130	0.010
protein alkylation	GO:0008213	81	0.010
regulation of wnt signaling pathway	GO:0030111	123	0.010
monocarboxylic acid biosynthetic process	GO:0072330	61	0.010
transmission of nerve impulse	GO:0019226	76	0.010
divalent inorganic cation homeostasis	GO:0072507	138	0.010
regulation of protein catabolic process	GO:0042176	108	0.010
nucleus organization	GO:0006997	45	0.010
muscle cell differentiation	GO:0042692	261	0.010
positive regulation of stem cell proliferation	GO:2000648	59	0.010
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.010
regulation of histone modification	GO:0031056	56	0.010

Upf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.049
disease of cellular proliferation	DOID:14566	0.049
musculoskeletal system disease	DOID:17	0.040
disease of anatomical entity	DOID:7	0.040
organ system cancer	DOID:0050686	0.034
immune system disease	DOID:2914	0.015
connective tissue disease	DOID:65	0.012

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