IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Rbl2

retinoblastoma-like 2

(Aliases: p130,Rb2)

Entrez: 19651
Ensembl: ENSMUSG00000031666
UniProtKB: Q64700

Process Predictions
Disease Predictions

Rbl2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
macromolecule catabolic process	GO:0009057	281	0.881
cellular response to dna damage stimulus	GO:0006974	207	0.747	Fly
protein catabolic process	GO:0030163	221	0.738
myeloid leukocyte differentiation	GO:0002573	119	0.707	Mouse
glial cell apoptotic process	GO:0034349	3	0.669	Mouse
myeloid cell homeostasis	GO:0002262	114	0.653	Mouse
regulation of engulfment of apoptotic cell	GO:1901074	2	0.621
peptidyl amino acid modification	GO:0018193	336	0.610
cellular protein catabolic process	GO:0044257	155	0.601
cellular macromolecule catabolic process	GO:0044265	206	0.590
cellular carbohydrate metabolic process	GO:0044262	119	0.582
apoptotic signaling pathway	GO:0097190	306	0.580	Fly
negative regulation of cell cycle	GO:0045786	123	0.579	Mouse Worm Fly
cellular ketone metabolic process	GO:0042180	84	0.571
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.562
cellular response to growth factor stimulus	GO:0071363	197	0.553
modification dependent macromolecule catabolic process	GO:0043632	133	0.545
glycogen metabolic process	GO:0005977	32	0.544
methylation	GO:0032259	134	0.526
regulation of cellular ketone metabolic process	GO:0010565	66	0.524
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.504	Mouse
cellular response to lipid	GO:0071396	145	0.502
oxidation reduction process	GO:0055114	342	0.495
regulation of apoptotic signaling pathway	GO:2001233	197	0.471
chromatin modification	GO:0016568	187	0.467
generation of precursor metabolites and energy	GO:0006091	103	0.464
ubiquitin dependent protein catabolic process	GO:0006511	129	0.448
macromolecule methylation	GO:0043414	120	0.437
regulation of myeloid cell differentiation	GO:0045637	96	0.433	Mouse
appendage development	GO:0048736	166	0.431
peptidyl lysine modification	GO:0018205	77	0.429
regulation of protein transport	GO:0051223	163	0.398
mitotic sister chromatid cohesion	GO:0007064	1	0.377	Fly
myeloid cell differentiation	GO:0030099	233	0.376	Mouse
protein kinase b signaling	GO:0043491	74	0.367
negative regulation of cell proliferation	GO:0008285	296	0.366	Mouse
epithelial cell proliferation	GO:0050673	174	0.342	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.337
monosaccharide metabolic process	GO:0005996	106	0.336
leukocyte differentiation	GO:0002521	342	0.334	Mouse
carbohydrate metabolic process	GO:0005975	230	0.331
erythrocyte differentiation	GO:0030218	88	0.329	Mouse
limb development	GO:0060173	166	0.328
energy derivation by oxidation of organic compounds	GO:0015980	77	0.316
positive regulation of apoptotic process	GO:0043065	217	0.310
male gamete generation	GO:0048232	285	0.305
response to nutrient levels	GO:0031667	109	0.299
cellular polysaccharide metabolic process	GO:0044264	38	0.299
response to growth factor	GO:0070848	198	0.295
regulation of leukocyte differentiation	GO:1902105	159	0.293	Mouse
regulation of protein localization	GO:0032880	231	0.284	Fly
limb morphogenesis	GO:0035108	149	0.282
response to endoplasmic reticulum stress	GO:0034976	53	0.279
intrinsic apoptotic signaling pathway	GO:0097193	132	0.269	Fly
histone modification	GO:0016570	159	0.268
regulation of membrane potential	GO:0042391	192	0.268
cellular lipid metabolic process	GO:0044255	323	0.262	Human
regulation of intracellular transport	GO:0032386	159	0.261
maintenance of location	GO:0051235	89	0.255
cohesin localization to chromatin	GO:0071921	1	0.255	Fly
regulation of cohesin localization to chromatin	GO:0071922	1	0.255	Fly
lipid homeostasis	GO:0055088	63	0.254
cellular response to acid chemical	GO:0071229	68	0.253
multicellular organism growth	GO:0035264	161	0.251	Worm
glucan metabolic process	GO:0044042	32	0.251
positive regulation of protein catabolic process	GO:0045732	60	0.232
negative regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0071930	1	0.231	Mouse
regulation of ossification	GO:0030278	112	0.228
regulation of epithelial cell proliferation	GO:0050678	141	0.227	Mouse
rhythmic process	GO:0048511	174	0.226
regulation of intracellular protein transport	GO:0033157	82	0.224
engulfment of apoptotic cell	GO:0043652	3	0.215
negative regulation of cell cycle phase transition	GO:1901988	48	0.214	Mouse Fly
regulation of defense response	GO:0031347	233	0.212
multicellular organismal homeostasis	GO:0048871	164	0.210
forebrain development	GO:0030900	302	0.209
modification dependent protein catabolic process	GO:0019941	133	0.208
homeostasis of number of cells	GO:0048872	210	0.208	Mouse
appendage morphogenesis	GO:0035107	149	0.207
mapk cascade	GO:0000165	281	0.206
cellular amino acid metabolic process	GO:0006520	103	0.204
cytokine production	GO:0001816	319	0.202
cell type specific apoptotic process	GO:0097285	268	0.202	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.200
mitotic cell cycle process	GO:1903047	159	0.199	Mouse Fly
striated muscle tissue development	GO:0014706	293	0.199	Mouse
response to organonitrogen compound	GO:0010243	246	0.198
negative regulation of cell cycle process	GO:0010948	69	0.197	Mouse Fly
gland development	GO:0048732	330	0.197
cellular response to peptide	GO:1901653	92	0.195
intra s dna damage checkpoint	GO:0031573	4	0.190
cellular response to lipopolysaccharide	GO:0071222	77	0.189
gene silencing	GO:0016458	38	0.188
regulation of establishment of protein localization	GO:0070201	181	0.186
defense response to other organism	GO:0098542	197	0.183
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.182
positive regulation of myeloid cell differentiation	GO:0045639	43	0.182	Mouse
cellular glucan metabolic process	GO:0006073	32	0.180
adaptive immune response	GO:0002250	155	0.180
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.180	Mouse
energy reserve metabolic process	GO:0006112	39	0.180
mitochondrion distribution	GO:0048311	4	0.178
membrane organization	GO:0061024	245	0.177
positive regulation of leukocyte differentiation	GO:1902107	86	0.177	Mouse
glycerophospholipid metabolic process	GO:0006650	71	0.177
cellular response to hormone stimulus	GO:0032870	150	0.173
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.172
protein ubiquitination	GO:0016567	171	0.171
response to extracellular stimulus	GO:0009991	127	0.170
polysaccharide metabolic process	GO:0005976	39	0.170
regulation of cartilage development	GO:0061035	44	0.165
chondrocyte differentiation	GO:0002062	72	0.162
negative regulation of protein modification process	GO:0031400	163	0.159
negative regulation of mitotic cell cycle	GO:0045930	58	0.155	Mouse Fly
embryonic appendage morphogenesis	GO:0035113	126	0.155
amine metabolic process	GO:0009308	45	0.155
hexose biosynthetic process	GO:0019319	39	0.155
glucose homeostasis	GO:0042593	128	0.154
regulation of g1 s transition of mitotic cell cycle	GO:2000045	35	0.153	Mouse Fly
positive regulation of macrophage differentiation	GO:0045651	5	0.152	Mouse
regionalization	GO:0003002	337	0.152
lymphocyte differentiation	GO:0030098	242	0.152
respiratory tube development	GO:0030323	167	0.151
extrinsic apoptotic signaling pathway	GO:0097191	126	0.151
spermatogenesis	GO:0007283	284	0.150
response to radiation	GO:0009314	165	0.150
chromatin organization	GO:0006325	206	0.149
connective tissue development	GO:0061448	179	0.148
regulation of cellular amino acid metabolic process	GO:0006521	5	0.148
cellular homeostasis	GO:0019725	240	0.147
histone acetylation	GO:0016573	41	0.147
mitochondrion organization	GO:0007005	134	0.147
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.144	Mouse Fly
regulation of osteoblast differentiation	GO:0045667	67	0.143
growth plate cartilage chondrocyte development	GO:0003431	3	0.140
cartilage condensation	GO:0001502	18	0.140
bone development	GO:0060348	120	0.140
regulation of glucose metabolic process	GO:0010906	60	0.140
negative regulation of molecular function	GO:0044092	258	0.138
protein oligomerization	GO:0051259	67	0.136
positive regulation of ossification	GO:0045778	47	0.135
digestive tract morphogenesis	GO:0048546	147	0.135	Worm
regulation of mapk cascade	GO:0043408	248	0.133
glycerolipid metabolic process	GO:0046486	122	0.132
ossification	GO:0001503	216	0.132
anatomical structure homeostasis	GO:0060249	145	0.131
metencephalon development	GO:0022037	89	0.131
protein modification by small protein conjugation	GO:0032446	187	0.130
protein modification by small protein conjugation or removal	GO:0070647	207	0.129
phospholipid metabolic process	GO:0006644	87	0.128
regulation of carbohydrate metabolic process	GO:0006109	75	0.127
cholesterol homeostasis	GO:0042632	44	0.126
histone methylation	GO:0016571	71	0.125
negative regulation of epithelial cell proliferation	GO:0050680	64	0.125	Mouse
cerebellum development	GO:0021549	77	0.124
biomineral tissue development	GO:0031214	64	0.122
cellular response to organonitrogen compound	GO:0071417	145	0.122
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.122	Mouse Fly
harderian gland development	GO:0070384	2	0.122
signal transduction in absence of ligand	GO:0038034	55	0.121
organonitrogen compound biosynthetic process	GO:1901566	192	0.119
positive regulation of programmed cell death	GO:0043068	218	0.119
lung development	GO:0030324	164	0.117
nucleotide metabolic process	GO:0009117	332	0.117
telencephalon development	GO:0021537	186	0.117
muscle cell differentiation	GO:0042692	261	0.116	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.115
phagocytosis	GO:0006909	66	0.115
reproductive behavior	GO:0019098	32	0.115	Worm
histone lysine methylation	GO:0034968	50	0.114
regulation of cellular amine metabolic process	GO:0033238	20	0.114
glucocorticoid mediated signaling pathway	GO:0043402	3	0.113
response to peptide	GO:1901652	136	0.112
carbohydrate biosynthetic process	GO:0016051	74	0.111
cell growth	GO:0016049	130	0.111
skeletal muscle cell differentiation	GO:0035914	66	0.111	Mouse
neural tube development	GO:0021915	160	0.109
gluconeogenesis	GO:0006094	39	0.109
regulation of dna binding	GO:0051101	39	0.109	Fly
reactive oxygen species biosynthetic process	GO:1903409	8	0.109
myeloid cell apoptotic process	GO:0033028	22	0.108
dna metabolic process	GO:0006259	303	0.106	Fly
positive regulation of secretion	GO:0051047	130	0.106
chromatin silencing	GO:0006342	15	0.105
canonical wnt signaling pathway	GO:0060070	130	0.105
proteasomal protein catabolic process	GO:0010498	98	0.105
dna modification	GO:0006304	50	0.104
bone mineralization	GO:0030282	54	0.104
response to starvation	GO:0042594	65	0.103
memory	GO:0007613	58	0.102
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.102
gliogenesis	GO:0042063	141	0.101
chondrocyte hypertrophy	GO:0003415	4	0.101
cellular chemical homeostasis	GO:0055082	215	0.101
regulation of fat cell differentiation	GO:0045598	81	0.101
nitrogen compound transport	GO:0071705	271	0.100
inflammatory response	GO:0006954	244	0.100
cellular response to external stimulus	GO:0071496	88	0.099
stem cell proliferation	GO:0072089	117	0.099
negative regulation of cellular component organization	GO:0051129	194	0.097
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.096
liver development	GO:0001889	66	0.096
regulation of binding	GO:0051098	111	0.095	Fly
response to insulin	GO:0032868	100	0.095
embryonic organ morphogenesis	GO:0048562	276	0.094	Worm
germ cell development	GO:0007281	185	0.094
heart morphogenesis	GO:0003007	178	0.092
regulation of mitotic cell cycle	GO:0007346	126	0.091	Mouse Fly
peptidyl lysine methylation	GO:0018022	29	0.091
cell division	GO:0051301	120	0.090	Mouse
monocarboxylic acid metabolic process	GO:0032787	191	0.089
innate immune response	GO:0045087	157	0.089
g protein coupled receptor signaling pathway	GO:0007186	243	0.089
protein acylation	GO:0043543	64	0.089
regulation of cellular response to stress	GO:0080135	159	0.089
developmental cell growth	GO:0048588	84	0.089
response to peptide hormone	GO:0043434	127	0.088
protein methylation	GO:0006479	81	0.088
covalent chromatin modification	GO:0016569	163	0.087
circadian rhythm	GO:0007623	114	0.087
positive regulation of transcription from rna polymerase ii promoter in response to stress	GO:0036003	3	0.087
nucleoside phosphate metabolic process	GO:0006753	338	0.086
mitotic cell cycle	GO:0000278	195	0.086	Mouse Fly
protein localization to membrane	GO:0072657	108	0.086
internal peptidyl lysine acetylation	GO:0018393	42	0.086
negative regulation of dna replication	GO:0008156	4	0.085	Fly
regulation of cell cycle g1 s phase transition	GO:1902806	35	0.085	Mouse Fly
protein localization to organelle	GO:0033365	185	0.084	Fly
monosaccharide biosynthetic process	GO:0046364	44	0.084
regulation of lymphocyte proliferation	GO:0050670	117	0.084
regulation of secretion	GO:0051046	274	0.083
regulation of chromatin modification	GO:1903308	57	0.083
lysosome organization	GO:0007040	21	0.083
urogenital system development	GO:0001655	261	0.083
wnt signaling pathway	GO:0016055	188	0.082
positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway	GO:1902237	3	0.082
regulation of cellular protein catabolic process	GO:1903362	61	0.082
cellular response to radiation	GO:0071478	28	0.082
renal system development	GO:0072001	225	0.081
locomotory behavior	GO:0007626	195	0.081
stem cell maintenance	GO:0019827	130	0.081
regulation of gluconeogenesis	GO:0006111	30	0.081
ovulation cycle	GO:0042698	59	0.081
epithelial tube morphogenesis	GO:0060562	303	0.080
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.079
regulation of chromosome organization	GO:0033044	83	0.078	Fly
ribonucleotide metabolic process	GO:0009259	291	0.078
regulation of cell activation	GO:0050865	289	0.078
bone morphogenesis	GO:0060349	78	0.078
protein localization to chromatin	GO:0071168	3	0.077	Fly
germ line stem cell division	GO:0042078	2	0.077
nucleoside phosphate biosynthetic process	GO:1901293	79	0.077
positive regulation of mitotic sister chromatid separation	GO:1901970	2	0.076
lipid localization	GO:0010876	126	0.076
germinal center formation	GO:0002467	16	0.076
negative regulation of ossification	GO:0030279	49	0.076
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.076
cellular amine metabolic process	GO:0044106	44	0.076
negative regulation of cell growth	GO:0030308	44	0.076
regulation of autophagy	GO:0010506	30	0.075
transmission of nerve impulse	GO:0019226	76	0.075
glycerolipid biosynthetic process	GO:0045017	50	0.075
cation transport	GO:0006812	399	0.074
multi multicellular organism process	GO:0044706	109	0.074	Worm
nucleobase containing small molecule metabolic process	GO:0055086	352	0.074
skin development	GO:0043588	220	0.074
alcohol catabolic process	GO:0046164	16	0.073
peptidyl lysine acetylation	GO:0018394	45	0.072
apoptotic cell clearance	GO:0043277	17	0.072
embryonic limb morphogenesis	GO:0030326	126	0.072
cognition	GO:0050890	149	0.071
regulation of cell cycle process	GO:0010564	160	0.071	Mouse Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.071
regulation of transferase activity	GO:0051338	263	0.071	Human
negative regulation of protein metabolic process	GO:0051248	282	0.070
carbohydrate homeostasis	GO:0033500	128	0.069
tissue homeostasis	GO:0001894	115	0.069
nuclear division	GO:0000280	158	0.068	Fly
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.068
purine containing compound biosynthetic process	GO:0072522	70	0.068
small molecule catabolic process	GO:0044282	71	0.068
cellular response to inorganic substance	GO:0071241	37	0.068
amide transport	GO:0042886	138	0.067
regulation of protein catabolic process	GO:0042176	108	0.067
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.067
carbohydrate derivative biosynthetic process	GO:1901137	183	0.067
internal protein amino acid acetylation	GO:0006475	42	0.067
telomere maintenance	GO:0000723	19	0.066
skeletal system morphogenesis	GO:0048705	203	0.065
male sex differentiation	GO:0046661	109	0.065
regulation of bone mineralization	GO:0030500	31	0.065
smoothened signaling pathway	GO:0007224	105	0.065	Mouse
response to light stimulus	GO:0009416	135	0.065
ion transmembrane transport	GO:0034220	361	0.064
posttranscriptional regulation of gene expression	GO:0010608	155	0.064
regulation of cellular catabolic process	GO:0031329	242	0.064
hindlimb morphogenesis	GO:0035137	42	0.064
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.063
regulation of protein kinase b signaling	GO:0051896	56	0.063
sensory perception	GO:0007600	245	0.063
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.063
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.062
regulation of biomineral tissue development	GO:0070167	33	0.062
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.061
fat cell differentiation	GO:0045444	160	0.061
negative regulation of cytokine production	GO:0001818	84	0.061
hexose metabolic process	GO:0019318	98	0.061
hepaticobiliary system development	GO:0061008	67	0.061
ribose phosphate metabolic process	GO:0019693	291	0.060
dna methylation	GO:0006306	43	0.060
lateral inhibition	GO:0046331	1	0.060
positive regulation of engulfment of apoptotic cell	GO:1901076	1	0.060
peptide transport	GO:0015833	133	0.060
sister chromatid cohesion	GO:0007062	12	0.060	Fly
response to monosaccharide	GO:0034284	67	0.059
regulation of cell cycle phase transition	GO:1901987	77	0.059	Mouse Fly
negative regulation of phosphorylation	GO:0042326	166	0.059
embryonic digestive tract morphogenesis	GO:0048557	17	0.059	Worm
regulation of protein stability	GO:0031647	52	0.059
immune response activating signal transduction	GO:0002757	116	0.058
response to sterol	GO:0036314	4	0.058
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.058
artery development	GO:0060840	53	0.058
positive regulation of cellular amine metabolic process	GO:0033240	5	0.058
regulation of histone methylation	GO:0031060	30	0.057
blastocyst development	GO:0001824	80	0.057
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.057
positive regulation of osteoblast differentiation	GO:0045669	34	0.056
sterol homeostasis	GO:0055092	45	0.056
learning or memory	GO:0007611	148	0.056
organic hydroxy compound metabolic process	GO:1901615	203	0.055
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.055
negative regulation of chondrocyte differentiation	GO:0032331	13	0.055
regulation of organelle organization	GO:0033043	289	0.055	Fly
cell cycle arrest	GO:0007050	37	0.054	Mouse Worm
mitochondrion localization	GO:0051646	9	0.054
lung alveolus development	GO:0048286	45	0.054
negative regulation of type b pancreatic cell apoptotic process	GO:2000675	3	0.054
digestive system development	GO:0055123	200	0.054	Mouse Worm
skeletal system development	GO:0001501	356	0.053
organophosphate biosynthetic process	GO:0090407	122	0.052
protein maturation	GO:0051604	176	0.052
regulation of lipid metabolic process	GO:0019216	118	0.052	Human
regulation of cell size	GO:0008361	72	0.052
chromosome segregation	GO:0007059	48	0.052	Fly
cartilage development	GO:0051216	140	0.052
protein localization to nucleus	GO:0034504	121	0.052
endochondral bone morphogenesis	GO:0060350	50	0.052
cellular response to abiotic stimulus	GO:0071214	56	0.051
response to molecule of bacterial origin	GO:0002237	143	0.051
regulation of secretion by cell	GO:1903530	249	0.051
regulation of homeostatic process	GO:0032844	182	0.051
negative regulation of protein transport	GO:0051224	46	0.051
organic hydroxy compound catabolic process	GO:1901616	25	0.050
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	18	0.050	Mouse Fly
keratinocyte differentiation	GO:0030216	48	0.050
divalent inorganic cation transport	GO:0072511	178	0.050
response to oxygen levels	GO:0070482	62	0.050
cellular response to monosaccharide stimulus	GO:0071326	47	0.050
positive regulation of dna templated transcription elongation	GO:0032786	2	0.049
hepatocyte apoptotic process	GO:0097284	11	0.049	Mouse
positive regulation of protein localization to nucleus	GO:1900182	30	0.049
cell aging	GO:0007569	35	0.049
regulation of dna templated transcription in response to stress	GO:0043620	9	0.049
regulation of cytoplasmic transport	GO:1903649	112	0.049
defense response to bacterium	GO:0042742	119	0.049
negative regulation of cell cycle g1 s phase transition	GO:1902807	18	0.048	Mouse Fly
embryonic epithelial tube formation	GO:0001838	130	0.048
regulation of leukocyte apoptotic process	GO:2000106	56	0.048
organic acid catabolic process	GO:0016054	51	0.048
regulation of canonical wnt signaling pathway	GO:0060828	82	0.048
regulation of lymphocyte activation	GO:0051249	240	0.047
myelination	GO:0042552	74	0.047
positive regulation of protein modification process	GO:0031401	299	0.047
regulation of innate immune response	GO:0045088	91	0.047
nucleoside catabolic process	GO:0009164	206	0.047
negative regulation of cellular amine metabolic process	GO:0033239	1	0.046
cellular response to retinoic acid	GO:0071300	25	0.046
intracellular distribution of mitochondria	GO:0048312	1	0.046
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.046
negative regulation of cell aging	GO:0090344	5	0.046
leukocyte apoptotic process	GO:0071887	71	0.046
cellular response to biotic stimulus	GO:0071216	92	0.046
plasma membrane organization	GO:0007009	90	0.046
positive regulation of histone methylation	GO:0031062	16	0.046
action potential	GO:0001508	78	0.046
nucleotide biosynthetic process	GO:0009165	78	0.045
ras protein signal transduction	GO:0007265	77	0.045
peptide secretion	GO:0002790	114	0.045
spermatid differentiation	GO:0048515	115	0.045
response to transforming growth factor beta	GO:0071559	88	0.045
microtubule based process	GO:0007017	236	0.045
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.045
regulation of protein ubiquitination	GO:0031396	52	0.045
phosphatidylinositol mediated signaling	GO:0048015	41	0.045
dendrite development	GO:0016358	115	0.045
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.044
positive regulation of defense response	GO:0031349	124	0.044
establishment of protein localization to plasma membrane	GO:0090002	34	0.044
enucleate erythrocyte differentiation	GO:0043353	8	0.044	Mouse
respiratory system development	GO:0060541	190	0.044
regulation of peptide hormone secretion	GO:0090276	75	0.044
protein processing	GO:0016485	163	0.044
protein localization to plasma membrane	GO:0072659	57	0.044
establishment of protein localization to membrane	GO:0090150	54	0.043
organelle assembly	GO:0070925	177	0.043
olfactory learning	GO:0008355	2	0.043
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.043
negative regulation of nervous system development	GO:0051961	156	0.042
carbohydrate catabolic process	GO:0016052	32	0.042
pole plasm assembly	GO:0007315	2	0.042
oocyte anterior posterior axis specification	GO:0007314	2	0.042
myeloid leukocyte activation	GO:0002274	83	0.042
regulation of system process	GO:0044057	200	0.042
regulation of neuron apoptotic process	GO:0043523	122	0.041
embryonic hindlimb morphogenesis	GO:0035116	32	0.041
cerebellum morphogenesis	GO:0021587	42	0.041
cell fate commitment	GO:0045165	210	0.041
peptidyl serine modification	GO:0018209	83	0.041
neuronal action potential	GO:0019228	54	0.041
cell maturation	GO:0048469	127	0.041	Mouse
calcium mediated signaling	GO:0019722	46	0.041
developmental growth involved in morphogenesis	GO:0060560	138	0.041
hair follicle development	GO:0001942	85	0.041
regulation of cell growth involved in cardiac muscle cell development	GO:0061050	3	0.041
regulation of t cell activation	GO:0050863	170	0.040
endochondral bone growth	GO:0003416	19	0.040
purine containing compound metabolic process	GO:0072521	311	0.040
purine nucleotide biosynthetic process	GO:0006164	65	0.040
central nervous system neuron differentiation	GO:0021953	162	0.040
regulation of lymphocyte differentiation	GO:0045619	107	0.040
histone h4 k16 acetylation	GO:0043984	3	0.040
cellular response to cytokine stimulus	GO:0071345	189	0.040
membrane invagination	GO:0010324	17	0.040
epidermis development	GO:0008544	187	0.040
cellular response to extracellular stimulus	GO:0031668	81	0.039
positive regulation of phagocytosis engulfment	GO:0060100	3	0.039
cell cycle g1 s phase transition	GO:0044843	57	0.039	Mouse Fly
cellular response to glucocorticoid stimulus	GO:0071385	13	0.039
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.039
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.039
multicellular organismal signaling	GO:0035637	91	0.038
positive regulation of intracellular transport	GO:0032388	70	0.038
positive regulation of innate immune response	GO:0045089	80	0.038
intestinal epithelial structure maintenance	GO:0060729	4	0.038
blood vessel morphogenesis	GO:0048514	285	0.038
mitochondrion transport along microtubule	GO:0047497	3	0.038
negative regulation of cellular protein metabolic process	GO:0032269	247	0.037
regulation of lipid kinase activity	GO:0043550	14	0.037	Human
nucleocytoplasmic transport	GO:0006913	139	0.037
regulation of ras protein signal transduction	GO:0046578	114	0.037
negative regulation of neuron projection development	GO:0010977	50	0.037
transmembrane transport	GO:0055085	412	0.037
peptidyl tyrosine modification	GO:0018212	145	0.036
organelle localization	GO:0051640	179	0.036
cardiac muscle tissue development	GO:0048738	130	0.036
cellular response to glucose stimulus	GO:0071333	45	0.036
positive regulation of behavior	GO:0048520	40	0.036
dna damage checkpoint	GO:0000077	26	0.036	Fly
cellular response to nitric oxide	GO:0071732	4	0.036
regulation of kinase activity	GO:0043549	249	0.036	Human
glycoprotein metabolic process	GO:0009100	116	0.035
autophagy	GO:0006914	45	0.035
positive regulation of growth	GO:0045927	104	0.035	Worm
negative regulation of immune system process	GO:0002683	209	0.035
peptidyl tyrosine phosphorylation	GO:0018108	143	0.035
ribose phosphate biosynthetic process	GO:0046390	59	0.035
lens development in camera type eye	GO:0002088	62	0.035
cell adhesion	GO:0007155	329	0.035
extracellular matrix organization	GO:0030198	147	0.035
gonad development	GO:0008406	141	0.035
mitotic g1 dna damage checkpoint	GO:0031571	4	0.035
cell proliferation in hindbrain	GO:0021534	10	0.035
t cell differentiation	GO:0030217	174	0.035
hormone secretion	GO:0046879	128	0.034
outflow tract morphogenesis	GO:0003151	53	0.034
regulation of histone modification	GO:0031056	56	0.034
response to retinoic acid	GO:0032526	56	0.034
mammary gland epithelium development	GO:0061180	65	0.034
intracellular protein transport	GO:0006886	204	0.034
glycoprotein biosynthetic process	GO:0009101	89	0.034
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.034
steroid hormone mediated signaling pathway	GO:0043401	6	0.034
negative regulation of mapk cascade	GO:0043409	65	0.034
hormone mediated signaling pathway	GO:0009755	23	0.034
glucose metabolic process	GO:0006006	92	0.034
signal transduction by p53 class mediator	GO:0072331	51	0.034
positive regulation of cytokine production	GO:0001819	174	0.034
female sex differentiation	GO:0046660	84	0.034
erk1 and erk2 cascade	GO:0070371	77	0.034
phospholipid transfer to membrane	GO:0006649	2	0.033

Rbl2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.126
disease of cellular proliferation	DOID:14566	0.096
cancer	DOID:162	0.088
organ system cancer	DOID:0050686	0.057

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network