IMP: Integrative Multi-species Prediction

Mus musculus

204 known processes

Ctr9

Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

(Aliases: KIAA0155,Sh2bp1,AA409336,Tsbp,mKIAA0155,Tsp)

Ensembl: ENSMUSG00000005609
Entrez: 22083
UniProtKB: Q62018
UniProtKB: Q05CJ7

Process Predictions
Disease Predictions

Ctr9 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
chromatin organization	GO:0006325	206	0.195
covalent chromatin modification	GO:0016569	163	0.153
protein modification by small protein conjugation	GO:0032446	187	0.140	Human Yeast
chromatin modification	GO:0016568	187	0.093
myeloid cell differentiation	GO:0030099	233	0.089	Human
mrna metabolic process	GO:0016071	84	0.087	Yeast
cellular response to dna damage stimulus	GO:0006974	207	0.073	Yeast
regulation of cellular amine metabolic process	GO:0033238	20	0.068
histone modification	GO:0016570	159	0.061
positive regulation of cell death	GO:0010942	224	0.060
stem cell differentiation	GO:0048863	268	0.054
peptidyl amino acid modification	GO:0018193	336	0.052
cellular amine metabolic process	GO:0044106	44	0.049
histone methylation	GO:0016571	71	0.048
regulation of cellular amino acid metabolic process	GO:0006521	5	0.047
digestive tract morphogenesis	GO:0048546	147	0.046
methylation	GO:0032259	134	0.046
positive regulation of dna templated transcription elongation	GO:0032786	2	0.045	Human Yeast
negative regulation of nervous system development	GO:0051961	156	0.042
stem cell development	GO:0048864	219	0.042
regulation of myeloid cell differentiation	GO:0045637	96	0.042	Human
negative regulation of dna replication	GO:0008156	4	0.039
membrane organization	GO:0061024	245	0.039
regulation of chromatin modification	GO:1903308	57	0.038
positive regulation of programmed cell death	GO:0043068	218	0.038
positive regulation of apoptotic process	GO:0043065	217	0.037
regulation of apoptotic signaling pathway	GO:2001233	197	0.036
homeostasis of number of cells	GO:0048872	210	0.036
mrna splicing via spliceosome	GO:0000398	43	0.036
nuclear division	GO:0000280	158	0.036
regulation of cell cycle	GO:0051726	281	0.036
germ cell development	GO:0007281	185	0.035
rna splicing	GO:0008380	54	0.034
histone lysine methylation	GO:0034968	50	0.034
negative regulation of cellular component organization	GO:0051129	194	0.034
negative regulation of cell development	GO:0010721	169	0.034
spermatogenesis	GO:0007283	284	0.034
macromolecule methylation	GO:0043414	120	0.034
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.033	Human
establishment of protein localization to organelle	GO:0072594	118	0.033
cellular macromolecule catabolic process	GO:0044265	206	0.032
male gamete generation	GO:0048232	285	0.032
posttranscriptional regulation of gene expression	GO:0010608	155	0.032
cellular ketone metabolic process	GO:0042180	84	0.031
myeloid cell homeostasis	GO:0002262	114	0.031
peptidyl lysine modification	GO:0018205	77	0.031
regulation of mrna metabolic process	GO:1903311	43	0.031
cell type specific apoptotic process	GO:0097285	268	0.030
protein modification by small protein conjugation or removal	GO:0070647	207	0.030	Human Yeast
protein ubiquitination	GO:0016567	171	0.030	Human Yeast
regulation of cellular ketone metabolic process	GO:0010565	66	0.029
negative regulation of immune system process	GO:0002683	209	0.029	Human
rna processing	GO:0006396	105	0.029	Yeast
protein alkylation	GO:0008213	81	0.029
protein modification by small protein removal	GO:0070646	21	0.028
erythrocyte differentiation	GO:0030218	88	0.028
regulation of lymphocyte activation	GO:0051249	240	0.027
apoptotic signaling pathway	GO:0097190	306	0.027
regulation of organelle organization	GO:0033043	289	0.027
negative regulation of neuron differentiation	GO:0045665	101	0.026
regulation of chromosome organization	GO:0033044	83	0.026
engulfment of apoptotic cell	GO:0043652	3	0.026
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.026
endoderm formation	GO:0001706	20	0.025
amine metabolic process	GO:0009308	45	0.025
regulation of protein complex assembly	GO:0043254	83	0.024	Yeast
mrna processing	GO:0006397	63	0.024	Yeast
cellular amino acid metabolic process	GO:0006520	103	0.024
regulation of membrane potential	GO:0042391	192	0.024
nucleobase containing small molecule metabolic process	GO:0055086	352	0.024
regulation of cellular response to stress	GO:0080135	159	0.024	Yeast
gliogenesis	GO:0042063	141	0.024
mitotic cell cycle	GO:0000278	195	0.023	Yeast
neural tube development	GO:0021915	160	0.023
response to lipopolysaccharide	GO:0032496	128	0.023
digestive tract development	GO:0048565	190	0.023
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.023
protein methylation	GO:0006479	81	0.022
protein localization to organelle	GO:0033365	185	0.021
cellular lipid metabolic process	GO:0044255	323	0.021
intracellular mrna localization	GO:0008298	4	0.021
gastrulation	GO:0007369	116	0.021
heterocycle catabolic process	GO:0046700	280	0.021
macromolecule catabolic process	GO:0009057	281	0.021
cellular nitrogen compound catabolic process	GO:0044270	280	0.020
cell activation involved in immune response	GO:0002263	126	0.020
formation of primary germ layer	GO:0001704	77	0.020
leukocyte differentiation	GO:0002521	342	0.020
regulation of neuron death	GO:1901214	134	0.020
regulation of neuron projection development	GO:0010975	169	0.019
glial cell differentiation	GO:0010001	131	0.019
ribose phosphate metabolic process	GO:0019693	291	0.019
regulation of defense response	GO:0031347	233	0.019
dna repair	GO:0006281	107	0.019	Yeast
purine nucleotide metabolic process	GO:0006163	302	0.019
immune effector process	GO:0002252	321	0.019
regulation of chromatin organization	GO:1902275	57	0.019
organelle assembly	GO:0070925	177	0.019
endomembrane system organization	GO:0010256	147	0.019
myelination	GO:0042552	74	0.018
neuron death	GO:0070997	154	0.018
positive regulation of chromatin modification	GO:1903310	28	0.018
oocyte axis specification	GO:0007309	2	0.018
regulation of cell projection organization	GO:0031344	206	0.018
regulation of neuron differentiation	GO:0045664	281	0.018
negative regulation of cell proliferation	GO:0008285	296	0.018
digestive system development	GO:0055123	200	0.018
modification dependent protein catabolic process	GO:0019941	133	0.018
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.018
regulation of vesicle mediated transport	GO:0060627	139	0.018
protein import	GO:0017038	101	0.017
male sex differentiation	GO:0046661	109	0.017
stem cell maintenance	GO:0019827	130	0.017
microtubule cytoskeleton organization	GO:0000226	157	0.017
regulation of cellular catabolic process	GO:0031329	242	0.017
muscle tissue development	GO:0060537	308	0.017
neuronal action potential	GO:0019228	54	0.017
protein catabolic process	GO:0030163	221	0.017
intracellular protein transport	GO:0006886	204	0.017
transmission of nerve impulse	GO:0019226	76	0.016
negative regulation of cell cycle	GO:0045786	123	0.016
cellularization	GO:0007349	1	0.016
aromatic compound catabolic process	GO:0019439	286	0.016
protein acylation	GO:0043543	64	0.016
organelle fission	GO:0048285	170	0.016
nitrogen compound transport	GO:0071705	271	0.016
organic cyclic compound catabolic process	GO:1901361	295	0.016
multicellular organism growth	GO:0035264	161	0.016
morphogenesis of embryonic epithelium	GO:0016331	159	0.015
regionalization	GO:0003002	337	0.015
positive regulation of cellular amine metabolic process	GO:0033240	5	0.015
cellular response to oxidative stress	GO:0034599	76	0.015
skin development	GO:0043588	220	0.015
camera type eye development	GO:0043010	266	0.015
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.015
forebrain development	GO:0030900	302	0.015
negative regulation of cellular amine metabolic process	GO:0033239	1	0.015
cellular component assembly involved in morphogenesis	GO:0010927	139	0.015
ensheathment of neurons	GO:0007272	76	0.015
positive regulation of cellular component biogenesis	GO:0044089	94	0.015
nucleotide metabolic process	GO:0009117	332	0.015
dna metabolic process	GO:0006259	303	0.015	Yeast
regulation of epithelial cell proliferation	GO:0050678	141	0.015
mitotic cell cycle process	GO:1903047	159	0.015	Yeast
nucleoside phosphate metabolic process	GO:0006753	338	0.014
leukocyte proliferation	GO:0070661	172	0.014
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.014
histone h3 k4 methylation	GO:0051568	23	0.014
ribonucleoside metabolic process	GO:0009119	245	0.014
small gtpase mediated signal transduction	GO:0007264	97	0.014
multicellular organismal signaling	GO:0035637	91	0.014
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.014
gene silencing	GO:0016458	38	0.014	Yeast
ribonucleotide metabolic process	GO:0009259	291	0.014
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.014
spermatid differentiation	GO:0048515	115	0.014
gtp catabolic process	GO:0006184	143	0.014
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.014
response to molecule of bacterial origin	GO:0002237	143	0.013
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.013
cell division	GO:0051301	120	0.013
oocyte anterior posterior axis specification	GO:0007314	2	0.013
purine ribonucleotide metabolic process	GO:0009150	290	0.013
cellular protein complex assembly	GO:0043623	116	0.013
regulation of mrna processing	GO:0050684	41	0.013
regulation of hydrolase activity	GO:0051336	246	0.013
cytoplasmic transport	GO:0016482	234	0.013
sensory organ morphogenesis	GO:0090596	242	0.013
dephosphorylation	GO:0016311	129	0.013
rna splicing via transesterification reactions	GO:0000375	43	0.013
response to radiation	GO:0009314	165	0.013
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.013
meiotic nuclear division	GO:0007126	115	0.013
positive regulation of organelle organization	GO:0010638	128	0.013
myeloid leukocyte differentiation	GO:0002573	119	0.013
intrinsic apoptotic signaling pathway	GO:0097193	132	0.013
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.013
action potential	GO:0001508	78	0.013
organonitrogen compound catabolic process	GO:1901565	264	0.013
negative regulation of multi organism process	GO:0043901	68	0.013
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.013
leukocyte activation involved in immune response	GO:0002366	126	0.013
viral process	GO:0016032	41	0.013
fertilization	GO:0009566	127	0.013
male anatomical structure morphogenesis	GO:0090598	4	0.012
positive regulation of nervous system development	GO:0051962	221	0.012
protein targeting to vacuole	GO:0006623	3	0.012
negative regulation of protein metabolic process	GO:0051248	282	0.012
epithelial cell proliferation	GO:0050673	174	0.012
rhythmic process	GO:0048511	174	0.012
nucleoside phosphate catabolic process	GO:1901292	222	0.012
modification dependent macromolecule catabolic process	GO:0043632	133	0.012
neuron apoptotic process	GO:0051402	142	0.012
pole plasm assembly	GO:0007315	2	0.012
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.012
negative regulation of organelle organization	GO:0010639	90	0.012
purine containing compound metabolic process	GO:0072521	311	0.012
dna replication	GO:0006260	52	0.012
skeletal system development	GO:0001501	356	0.012
response to acid chemical	GO:0001101	111	0.012
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.012
gland development	GO:0048732	330	0.012
regulation of ral gtpase activity	GO:0032315	4	0.012
regulation of cell activation	GO:0050865	289	0.012
positive regulation of lymphocyte activation	GO:0051251	140	0.012
regulation of mrna splicing via spliceosome	GO:0048024	32	0.012
negative regulation of molecular function	GO:0044092	258	0.011
ribonucleoprotein complex disassembly	GO:0032988	3	0.011
regulation of mitotic cell cycle	GO:0007346	126	0.011
regulation of gliogenesis	GO:0014013	50	0.011
regulation of histone modification	GO:0031056	56	0.011
male gonad development	GO:0008584	88	0.011
regulation of cellular protein catabolic process	GO:1903362	61	0.011
histone deacetylation	GO:0016575	26	0.011
lens development in camera type eye	GO:0002088	62	0.011
oocyte construction	GO:0007308	2	0.011
male genitalia morphogenesis	GO:0048808	4	0.011
transcription elongation from rna polymerase ii promoter	GO:0006368	9	0.011	Human Yeast
maintenance of location	GO:0051235	89	0.011
response to organonitrogen compound	GO:0010243	246	0.011
meiotic cell cycle	GO:0051321	122	0.011
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.011
glycerolipid metabolic process	GO:0046486	122	0.011
blood vessel morphogenesis	GO:0048514	285	0.011
regulation of cytoplasmic transport	GO:1903649	112	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.011
dna endoreduplication	GO:0042023	4	0.011
negative regulation of neuron apoptotic process	GO:0043524	92	0.011
response to oxidative stress	GO:0006979	123	0.011
regulation of hormone levels	GO:0010817	211	0.011
axon target recognition	GO:0007412	4	0.011
internal peptidyl lysine acetylation	GO:0018393	42	0.011
positive regulation of chromosome organization	GO:2001252	33	0.011
histone deubiquitination	GO:0016578	2	0.011
protein polymerization	GO:0051258	57	0.011
gonad development	GO:0008406	141	0.011
purine ribonucleotide catabolic process	GO:0009154	208	0.010
lateral inhibition	GO:0046331	1	0.010
negative regulation of dna dependent dna replication	GO:2000104	1	0.010
regulation of cell motility	GO:2000145	236	0.010
nucleoside triphosphate metabolic process	GO:0009141	230	0.010
double strand break repair	GO:0006302	48	0.010
positive regulation of proteolysis	GO:0045862	85	0.010
response to organic cyclic compound	GO:0014070	198	0.010
peptidyl tyrosine phosphorylation	GO:0018108	143	0.010
protein targeting	GO:0006605	143	0.010
leukocyte mediated immunity	GO:0002443	174	0.010
molting cycle	GO:0042303	90	0.010
regulation of neuron apoptotic process	GO:0043523	122	0.010
multicellular organismal homeostasis	GO:0048871	164	0.010
proteasomal protein catabolic process	GO:0010498	98	0.010
lipid modification	GO:0030258	65	0.010
glycosyl compound metabolic process	GO:1901657	246	0.010

Ctr9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
organ system cancer	DOID:0050686	0.033
disease of cellular proliferation	DOID:14566	0.033
cancer	DOID:162	0.033
disease of anatomical entity	DOID:7	0.019
nervous system disease	DOID:863	0.019
immune system disease	DOID:2914	0.011
sensory system disease	DOID:0050155	0.010

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