IMP: Integrative Multi-species Prediction

Mus musculus

111 known processes

Abca1

ATP-binding cassette, sub-family A (ABC1), member 1

(Aliases: Abc1)

Ensembl: ENSMUSG00000015243
Entrez: 11303
UniProtKB: P41233
UniProtKB: Q8BPY1

Process Predictions
Disease Predictions

Abca1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
reverse cholesterol transport	GO:0043691	6	1.000
regulation of sterol transport	GO:0032371	17	0.999
positive regulation of sterol transport	GO:0032373	9	0.999
protein lipid complex subunit organization	GO:0071825	12	0.999	Human
cholesterol homeostasis	GO:0042632	44	0.997	Human
phospholipid transport	GO:0015914	21	0.996
sterol homeostasis	GO:0055092	45	0.996	Human
lipid homeostasis	GO:0055088	63	0.996	Human Mouse
sterol metabolic process	GO:0016125	58	0.995
sterol transport	GO:0015918	38	0.995
plasma lipoprotein particle remodeling	GO:0034369	6	0.994
intracellular cholesterol transport	GO:0032367	3	0.994	Human
cholesterol transport	GO:0030301	38	0.991
organophosphate ester transport	GO:0015748	28	0.989
regulation of cholesterol transport	GO:0032374	17	0.988
cholesterol efflux	GO:0033344	24	0.988
plasma lipoprotein particle organization	GO:0071827	11	0.981	Human
positive regulation of cholesterol transport	GO:0032376	9	0.981
regulation of plasma lipoprotein particle levels	GO:0097006	23	0.972	Human
cholesterol metabolic process	GO:0008203	56	0.963
organic anion transport	GO:0015711	137	0.960
negative regulation of sterol transport	GO:0032372	4	0.936
phospholipid efflux	GO:0033700	3	0.934
organic hydroxy compound transport	GO:0015850	93	0.934
intracellular sterol transport	GO:0032366	3	0.922	Human
negative regulation of cholesterol transport	GO:0032375	4	0.907
intracellular lipid transport	GO:0032365	3	0.902	Human
positive regulation of lipid transport	GO:0032370	22	0.898
regulation of lipid transport	GO:0032368	36	0.896
cholesterol esterification	GO:0034435	3	0.882
negative regulation of lipid transport	GO:0032369	8	0.868
regulation of cholesterol metabolic process	GO:0090181	14	0.864
positive regulation of cholesterol efflux	GO:0010875	9	0.858
regulation of cholesterol biosynthetic process	GO:0045540	8	0.857
lipid localization	GO:0010876	126	0.846
high density lipoprotein particle remodeling	GO:0034375	4	0.843
lipid transport	GO:0006869	98	0.839
anion transport	GO:0006820	177	0.834
plasma lipoprotein particle clearance	GO:0034381	13	0.825
amine metabolic process	GO:0009308	45	0.816
positive regulation of lipid biosynthetic process	GO:0046889	18	0.813
sterol esterification	GO:0034434	3	0.806
steroid metabolic process	GO:0008202	119	0.803
regulation of cholesterol efflux	GO:0010874	13	0.713
alcohol metabolic process	GO:0006066	116	0.696
macromolecular complex remodeling	GO:0034367	6	0.690
positive regulation of lipid metabolic process	GO:0045834	40	0.682
cholesterol biosynthetic process	GO:0006695	15	0.638
lipid biosynthetic process	GO:0008610	179	0.637
steroid esterification	GO:0034433	3	0.636
negative regulation of immune system process	GO:0002683	209	0.607
regulation of lipid metabolic process	GO:0019216	118	0.600
regulation of defense response	GO:0031347	233	0.593
triglyceride metabolic process	GO:0006641	51	0.591
organic hydroxy compound metabolic process	GO:1901615	203	0.564
regulation of beta amyloid clearance	GO:1900221	1	0.562	Mouse
cytokine production	GO:0001816	319	0.561	Human
regulation of cellular catabolic process	GO:0031329	242	0.551
glycerolipid metabolic process	GO:0046486	122	0.530
regulation of response to wounding	GO:1903034	189	0.526
innate immune response	GO:0045087	157	0.521
anion homeostasis	GO:0055081	16	0.511	Human
adaptive immune response	GO:0002250	155	0.494
glucocorticoid metabolic process	GO:0008211	9	0.483
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis	GO:2000148	1	0.479
intestinal cholesterol absorption	GO:0030299	5	0.465
regulation of cellular ketone metabolic process	GO:0010565	66	0.463
glycerophospholipid metabolic process	GO:0006650	71	0.460
low density lipoprotein particle remodeling	GO:0034374	2	0.458
sterol biosynthetic process	GO:0016126	17	0.450
response to low density lipoprotein particle	GO:0055098	2	0.443	Human
activation of immune response	GO:0002253	138	0.441
defense response to other organism	GO:0098542	197	0.441
response to lipopolysaccharide	GO:0032496	128	0.441
positive regulation of presynaptic membrane organization	GO:1901631	1	0.439
phospholipid homeostasis	GO:0055091	6	0.437	Human
regulation of adaptive immune response	GO:0002819	90	0.419
negative regulation of cell proliferation	GO:0008285	296	0.385
cellular amino acid metabolic process	GO:0006520	103	0.368
phospholipid metabolic process	GO:0006644	87	0.367
blood vessel morphogenesis	GO:0048514	285	0.366
cellular lipid metabolic process	GO:0044255	323	0.366
neutral lipid metabolic process	GO:0006638	57	0.363
cellular response to molecule of bacterial origin	GO:0071219	83	0.357
protein lipid complex remodeling	GO:0034368	6	0.356
negative regulation of cell activation	GO:0050866	111	0.348
regulation of inflammatory response	GO:0050727	147	0.347
lipid modification	GO:0030258	65	0.345
alcohol catabolic process	GO:0046164	16	0.332
epithelial cell proliferation	GO:0050673	174	0.330
mapk cascade	GO:0000165	281	0.320	Mouse
inflammatory response	GO:0006954	244	0.316
high density lipoprotein particle assembly	GO:0034380	3	0.316	Human
regulation of protein kinase activity	GO:0045859	232	0.313
carbohydrate metabolic process	GO:0005975	230	0.310
peptidyl tyrosine phosphorylation	GO:0018108	143	0.307
lipid catabolic process	GO:0016042	69	0.304
cation homeostasis	GO:0055080	212	0.302
production of molecular mediator of immune response	GO:0002440	103	0.301
formation of radial glial scaffolds	GO:0021943	4	0.297
carbohydrate derivative biosynthetic process	GO:1901137	183	0.287	Human Mouse
regulation of phospholipid efflux	GO:1902994	2	0.284	Mouse
macromolecule catabolic process	GO:0009057	281	0.281
cellular ketone metabolic process	GO:0042180	84	0.279
protein catabolic process	GO:0030163	221	0.278
regulation of lymphocyte activation	GO:0051249	240	0.272
negative regulation of lipid storage	GO:0010888	6	0.269
cytokine mediated signaling pathway	GO:0019221	115	0.267
t cell activation	GO:0042110	289	0.267
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.265
regulation of kinase activity	GO:0043549	249	0.264
positive regulation of steroid metabolic process	GO:0045940	5	0.258
positive regulation of innate immune response	GO:0045089	80	0.255
cellular amine metabolic process	GO:0044106	44	0.255
regulation of cellular amino acid metabolic process	GO:0006521	5	0.252
regulation of transferase activity	GO:0051338	263	0.247
steroid biosynthetic process	GO:0006694	47	0.246
acylglycerol metabolic process	GO:0006639	55	0.244
regulation of leukocyte mediated immunity	GO:0002703	104	0.237
purine nucleotide metabolic process	GO:0006163	302	0.237	Human Mouse
regulation of intestinal cholesterol absorption	GO:0030300	4	0.234
regulation of t cell activation	GO:0050863	170	0.233
small molecule biosynthetic process	GO:0044283	132	0.232
sterol transmembrane transport	GO:0035382	2	0.229
nucleoside phosphate metabolic process	GO:0006753	338	0.229	Human Mouse
regulation of phospholipase a2 activity	GO:0032429	3	0.225
positive regulation of transferase activity	GO:0051347	167	0.225
regulation of cellular response to stress	GO:0080135	159	0.223
acylglycerol homeostasis	GO:0055090	16	0.223
protein modification by small protein conjugation or removal	GO:0070647	207	0.221
regulation of cell activation	GO:0050865	289	0.215
urogenital system development	GO:0001655	261	0.214
cell substrate adhesion	GO:0031589	130	0.212
negative regulation of cellular amide metabolic process	GO:0034249	4	0.212	Mouse
response to organic cyclic compound	GO:0014070	198	0.211
negative regulation of defense response	GO:0031348	77	0.211
cellular biogenic amine metabolic process	GO:0006576	28	0.210
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.209
cellular macromolecule catabolic process	GO:0044265	206	0.208
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis	GO:2000166	1	0.207
regulation of cytokine production	GO:0001817	266	0.206
nucleotide metabolic process	GO:0009117	332	0.205	Human Mouse
intestinal absorption	GO:0050892	13	0.204
positive regulation of lymphocyte activation	GO:0051251	140	0.201
low density lipoprotein particle clearance	GO:0034383	8	0.199
positive regulation of protein phosphorylation	GO:0001934	242	0.199
cell activation involved in immune response	GO:0002263	126	0.193
protein processing	GO:0016485	163	0.192
regulation of lipid storage	GO:0010883	20	0.191
protein glycosylation	GO:0006486	55	0.190
glycerolipid biosynthetic process	GO:0045017	50	0.187
triglyceride biosynthetic process	GO:0019432	17	0.186
alcohol biosynthetic process	GO:0046165	43	0.184
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.184
lymphocyte differentiation	GO:0030098	242	0.183
g protein coupled receptor signaling pathway	GO:0007186	243	0.183	Human
spermatid differentiation	GO:0048515	115	0.182
spermatid development	GO:0007286	108	0.179
morphogenesis of a branching epithelium	GO:0061138	193	0.179
angiogenesis	GO:0001525	201	0.176
lipoprotein biosynthetic process	GO:0042158	33	0.174
ribonucleotide metabolic process	GO:0009259	291	0.174	Human Mouse
regulation of phospholipid transport	GO:2001138	4	0.173	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.173
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO:2000162	1	0.170
small molecule catabolic process	GO:0044282	71	0.170
positive regulation of dendrite development	GO:1900006	21	0.169
regulation of body fluid levels	GO:0050878	162	0.168	Mouse
cellular protein catabolic process	GO:0044257	155	0.168
regulation of proteolysis	GO:0030162	164	0.165
cdc42 protein signal transduction	GO:0032488	0	0.164	Human
canonical wnt signaling pathway involved in heart development	GO:0061316	3	0.164
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	GO:0061324	2	0.163
positive regulation of cytokine production	GO:0001819	174	0.162
peptidyl amino acid modification	GO:0018193	336	0.162
cellularization	GO:0007349	1	0.162
extrinsic apoptotic signaling pathway	GO:0097191	126	0.159
glycosylation	GO:0070085	62	0.158
glial cell differentiation	GO:0010001	131	0.158
posttranscriptional regulation of gene expression	GO:0010608	155	0.157
toxin transport	GO:1901998	38	0.157
maintenance of location	GO:0051235	89	0.156
response to nutrient levels	GO:0031667	109	0.156
leukocyte activation involved in immune response	GO:0002366	126	0.156
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.155
regulation of phosphatidylcholine catabolic process	GO:0010899	2	0.155
nucleobase containing small molecule metabolic process	GO:0055086	352	0.155	Human Mouse
organic hydroxy compound biosynthetic process	GO:1901617	77	0.155
immune effector process	GO:0002252	321	0.154
regulation of cellular protein catabolic process	GO:1903362	61	0.153
regulation of secretion by cell	GO:1903530	249	0.152
regulation of mapk cascade	GO:0043408	248	0.152	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.150
positive regulation of nervous system development	GO:0051962	221	0.150
negative regulation of inflammatory response	GO:0050728	61	0.150
regulation of planar cell polarity pathway involved in outflow tract morphogenesis	GO:2000163	1	0.148
macromolecule glycosylation	GO:0043413	55	0.148
negative regulation of protein metabolic process	GO:0051248	282	0.146	Mouse
cellular chemical homeostasis	GO:0055082	215	0.146
immune response activating signal transduction	GO:0002757	116	0.146
regulation of cell migration	GO:0030334	219	0.145
cholesterol catabolic process	GO:0006707	5	0.145
ion transmembrane transport	GO:0034220	361	0.145
protein ubiquitination	GO:0016567	171	0.142
chemotaxis	GO:0006935	247	0.141
connective tissue development	GO:0061448	179	0.140
defense response to bacterium	GO:0042742	119	0.140
male gamete generation	GO:0048232	285	0.138
negative regulation of platelet derived growth factor receptor beta signaling pathway	GO:2000587	2	0.137
gland development	GO:0048732	330	0.136
positive regulation of defense response	GO:0031349	124	0.135
neuron death	GO:0070997	154	0.135
transmembrane transport	GO:0055085	412	0.133
regulation of cellular amine metabolic process	GO:0033238	20	0.133
regulation of cholesterol esterification	GO:0010872	2	0.133
negative regulation of cellular component organization	GO:0051129	194	0.132
regulation of digestive system process	GO:0044058	13	0.132
positive regulation of cellular protein catabolic process	GO:1903364	34	0.132
peptidyl tyrosine modification	GO:0018212	145	0.131
skin development	GO:0043588	220	0.130	Mouse
regulation of steroid biosynthetic process	GO:0050810	26	0.129
leukocyte migration	GO:0050900	124	0.129
regulation of membrane protein ectodomain proteolysis	GO:0051043	3	0.129
negative regulation of epithelial cell proliferation	GO:0050680	64	0.129
ribose phosphate metabolic process	GO:0019693	291	0.128	Human Mouse
lipoprotein metabolic process	GO:0042157	43	0.128
negative regulation of cellular protein metabolic process	GO:0032269	247	0.128
immune response regulating signaling pathway	GO:0002764	125	0.128
kidney development	GO:0001822	213	0.128
lipid storage	GO:0019915	36	0.127
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.126	Mouse
cellular calcium ion homeostasis	GO:0006874	119	0.126
regulation of neuron differentiation	GO:0045664	281	0.125
cellular response to lipid	GO:0071396	145	0.124
stem cell maintenance	GO:0019827	130	0.124
positive regulation of programmed cell death	GO:0043068	218	0.124
modification dependent macromolecule catabolic process	GO:0043632	133	0.123
membrane organization	GO:0061024	245	0.121
positive regulation of steroid biosynthetic process	GO:0010893	4	0.120
cytokine production involved in immune response	GO:0002367	34	0.120
regulation of removal of superoxide radicals	GO:2000121	4	0.119
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.119
regulation of map kinase activity	GO:0043405	120	0.118
monocarboxylic acid metabolic process	GO:0032787	191	0.118
organic cyclic compound catabolic process	GO:1901361	295	0.117	Mouse
positive regulation of cellular catabolic process	GO:0031331	148	0.116
hindbrain development	GO:0030902	128	0.116
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis	GO:2000149	1	0.115
response to oxidative stress	GO:0006979	123	0.114
neutral lipid biosynthetic process	GO:0046460	18	0.114
cellular response to hormone stimulus	GO:0032870	150	0.114
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.113
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.112	Mouse
positive regulation of cell activation	GO:0050867	158	0.112
positive regulation of apoptotic process	GO:0043065	217	0.112
modification dependent protein catabolic process	GO:0019941	133	0.111
apoptotic signaling pathway	GO:0097190	306	0.111
regulation of endocytosis	GO:0030100	69	0.110	Mouse
positive regulation of protein catabolic process	GO:0045732	60	0.108
positive regulation of protein kinase b signaling	GO:0051897	32	0.108
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.107
nucleoside monophosphate metabolic process	GO:0009123	85	0.107	Mouse
sterol catabolic process	GO:0016127	5	0.107
negative regulation of response to wounding	GO:1903035	77	0.106
beta amyloid formation	GO:0034205	9	0.106	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.105	Mouse
coagulation	GO:0050817	78	0.104
plasma lipoprotein particle assembly	GO:0034377	6	0.104	Human
b cell activation	GO:0042113	161	0.104
calcium ion homeostasis	GO:0055074	127	0.104
reactive oxygen species biosynthetic process	GO:1903409	8	0.104
erythrocyte differentiation	GO:0030218	88	0.103
negative regulation of cytokine production	GO:0001818	84	0.102
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.101
organic hydroxy compound catabolic process	GO:1901616	25	0.101
positive regulation of ion transport	GO:0043270	65	0.101	Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.101
positive regulation of lipid storage	GO:0010884	10	0.100
regulation of lipid biosynthetic process	GO:0046890	54	0.100
muscle tissue development	GO:0060537	308	0.100
axonogenesis	GO:0007409	274	0.100
glycoprotein biosynthetic process	GO:0009101	89	0.099	Mouse
neuron apoptotic process	GO:0051402	142	0.099
appendage development	GO:0048736	166	0.099
regulation of hormone levels	GO:0010817	211	0.098
cellular ion homeostasis	GO:0006873	165	0.098
protein localization to membrane	GO:0072657	108	0.098
regulation of steroid metabolic process	GO:0019218	39	0.097
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:2000060	8	0.097
positive regulation of cholesterol biosynthetic process	GO:0045542	3	0.096
lipid digestion	GO:0044241	7	0.096
positive regulation of cell development	GO:0010720	237	0.096
cellular response to oxidative stress	GO:0034599	76	0.096
ribonucleotide catabolic process	GO:0009261	208	0.095	Mouse
female sex differentiation	GO:0046660	84	0.095
regulation of rho protein signal transduction	GO:0035023	71	0.094	Human
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis	GO:2000164	1	0.094
lipoprotein catabolic process	GO:0042159	7	0.094
regulation of planar cell polarity pathway involved in neural tube closure	GO:2000167	1	0.094
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.093
phagocytosis	GO:0006909	66	0.093
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.091
spermatogenesis	GO:0007283	284	0.091
positive regulation of cellular amine metabolic process	GO:0033240	5	0.091
peptide metabolic process	GO:0006518	46	0.091	Mouse
forebrain development	GO:0030900	302	0.089
b cell proliferation	GO:0042100	53	0.089
negative regulation of endothelial cell proliferation	GO:0001937	8	0.088
regulation of epithelial cell proliferation	GO:0050678	141	0.088
respiratory tube development	GO:0030323	167	0.087	Mouse
digestive tract development	GO:0048565	190	0.087
tissue remodeling	GO:0048771	102	0.086
positive regulation of protein modification process	GO:0031401	299	0.086
positive regulation of t cell activation	GO:0050870	101	0.086
cholesterol import	GO:0070508	2	0.085
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.085
receptor mediated endocytosis of low density lipoprotein particle involved in cholesterol transport	GO:0090118	1	0.084
innate immune response activating signal transduction	GO:0002758	50	0.084
response to molecule of bacterial origin	GO:0002237	143	0.084
lymphocyte mediated immunity	GO:0002449	139	0.084
dendritic spine maintenance	GO:0097062	4	0.084
multicellular organismal signaling	GO:0035637	91	0.084
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.083
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.083
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.083
negative regulation of protein phosphorylation	GO:0001933	126	0.083
nuclear transport	GO:0051169	139	0.082
organic acid transport	GO:0015849	101	0.082
regulation of innate immune response	GO:0045088	91	0.081
response to steroid hormone	GO:0048545	56	0.081
wnt signaling pathway	GO:0016055	188	0.081
regulation of multi organism process	GO:0043900	111	0.080
regulation of fat cell differentiation	GO:0045598	81	0.080
positive regulation of glial cell proliferation	GO:0060252	4	0.080
response to peptide hormone	GO:0043434	127	0.080
amyloid precursor protein catabolic process	GO:0042987	10	0.080	Mouse
very low density lipoprotein particle remodeling	GO:0034372	1	0.080
defense response to gram positive bacterium	GO:0050830	50	0.079
stress activated protein kinase signaling cascade	GO:0031098	81	0.078
glucose metabolic process	GO:0006006	92	0.078
dendritic spine development	GO:0060996	30	0.078
organonitrogen compound biosynthetic process	GO:1901566	192	0.078	Human
negative regulation of phosphorylation	GO:0042326	166	0.078
ribonucleoside metabolic process	GO:0009119	245	0.077	Mouse
cellular response to lipopolysaccharide	GO:0071222	77	0.077
regulation of neuron apoptotic process	GO:0043523	122	0.077
negative regulation of neuron death	GO:1901215	98	0.077
negative regulation of planar cell polarity pathway involved in heart morphogenesis	GO:2000160	1	0.076
regulation of protein processing	GO:0070613	96	0.076
positive regulation of protein kinase activity	GO:0045860	144	0.076
positive regulation of kinase activity	GO:0033674	155	0.076
activation of innate immune response	GO:0002218	56	0.075
extracellular structure organization	GO:0043062	148	0.075
regulation of b cell activation	GO:0050864	81	0.075
regulation of protein serine threonine kinase activity	GO:0071900	157	0.075
autophagy	GO:0006914	45	0.075
cellular homeostasis	GO:0019725	240	0.075
stem cell proliferation	GO:0072089	117	0.075
positive regulation of amyloid precursor protein catabolic process	GO:1902993	4	0.074
regulation of interleukin 6 production	GO:0032675	55	0.074
positive regulation of secretion by cell	GO:1903532	114	0.073
t cell proliferation	GO:0042098	120	0.073
regulation of non canonical wnt signaling pathway	GO:2000050	12	0.073
positive regulation of beta amyloid formation	GO:1902004	4	0.073
regulation of triglyceride biosynthetic process	GO:0010866	10	0.072
leukocyte proliferation	GO:0070661	172	0.072
somatic cell dna recombination	GO:0016444	51	0.072
regulation of hydrolase activity	GO:0051336	246	0.072
heterocycle catabolic process	GO:0046700	280	0.071	Mouse
negative regulation of cholesterol efflux	GO:0090370	4	0.071
divalent inorganic cation homeostasis	GO:0072507	138	0.071
positive regulation of neuron differentiation	GO:0045666	141	0.071
regulation of nucleotide metabolic process	GO:0006140	169	0.071	Human
nucleoside phosphate catabolic process	GO:1901292	222	0.070	Mouse
protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:0042787	25	0.070
cell adhesion	GO:0007155	329	0.070
glycerophospholipid biosynthetic process	GO:0046474	32	0.069
regulation of lymphocyte mediated immunity	GO:0002706	84	0.069
sperm individualization	GO:0007291	1	0.069
regulation of leukocyte proliferation	GO:0070663	121	0.069
blood coagulation	GO:0007596	76	0.069
excretion	GO:0007588	22	0.068
placenta development	GO:0001890	140	0.068
multicellular organism growth	GO:0035264	161	0.068
renal system development	GO:0072001	225	0.068
endocytosis	GO:0006897	168	0.068
lymphocyte activation involved in immune response	GO:0002285	93	0.068
tissue homeostasis	GO:0001894	115	0.068	Mouse
ubiquitin dependent protein catabolic process	GO:0006511	129	0.067
negative regulation of alcohol biosynthetic process	GO:1902931	4	0.067
cell proliferation in hindbrain	GO:0021534	10	0.067
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.067
regulation of ras protein signal transduction	GO:0046578	114	0.066	Human
regulation of blood coagulation	GO:0030193	28	0.065
sphingolipid metabolic process	GO:0006665	45	0.065
regulation of neurofibrillary tangle assembly	GO:1902996	1	0.065
regulation of anatomical structure size	GO:0090066	178	0.065
small gtpase mediated signal transduction	GO:0007264	97	0.065	Human
defense response to gram negative bacterium	GO:0050829	28	0.064
liver development	GO:0001889	66	0.064
aromatic compound catabolic process	GO:0019439	286	0.064	Mouse
activation of mapkk activity	GO:0000186	15	0.064
organophosphate catabolic process	GO:0046434	232	0.064	Mouse
regulation of angiogenesis	GO:0045765	81	0.064
glycerolipid catabolic process	GO:0046503	16	0.063
antigen receptor mediated signaling pathway	GO:0050851	64	0.063
planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO:0061349	2	0.063
positive regulation of hydrolase activity	GO:0051345	148	0.063
negative regulation of protein maturation	GO:1903318	79	0.063
positive regulation of protein modification by small protein conjugation or removal	GO:1903322	30	0.063
organonitrogen compound catabolic process	GO:1901565	264	0.063	Mouse
digestive tract morphogenesis	GO:0048546	147	0.063
digestion	GO:0007586	40	0.062
regulation of tube size	GO:0035150	57	0.062
regulation of protein catabolic process	GO:0042176	108	0.061
triglyceride rich lipoprotein particle remodeling	GO:0034370	2	0.061
neural precursor cell proliferation	GO:0061351	121	0.061
negative regulation of nervous system development	GO:0051961	156	0.061
somatic stem cell maintenance	GO:0035019	47	0.060
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.060
negative regulation of neuron apoptotic process	GO:0043524	92	0.060
immunoglobulin mediated immune response	GO:0016064	69	0.060
positive regulation of inflammatory response	GO:0050729	47	0.059
glycosyl compound metabolic process	GO:1901657	246	0.059	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.058
epidermis development	GO:0008544	187	0.058	Mouse
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering	GO:0097113	3	0.058
ribonucleoside catabolic process	GO:0042454	206	0.058	Mouse
protein kinase b signaling	GO:0043491	74	0.058
glycoprotein metabolic process	GO:0009100	116	0.058	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.058
cellular response to organic cyclic compound	GO:0071407	87	0.058
cellular response to external stimulus	GO:0071496	88	0.057
positive regulation of adaptive immune response	GO:0002821	61	0.057
innate immune response in mucosa	GO:0002227	3	0.057
regulation of protein kinase b signaling	GO:0051896	56	0.057
regulation of presynaptic membrane organization	GO:1901629	3	0.057
cerebellum development	GO:0021549	77	0.056
regulation of production of molecular mediator of immune response	GO:0002700	65	0.056
regulation of apoptotic signaling pathway	GO:2001233	197	0.056
negative regulation of hydrolase activity	GO:0051346	71	0.056
organophosphate biosynthetic process	GO:0090407	122	0.056	Human
cell maturation	GO:0048469	127	0.056
heart morphogenesis	GO:0003007	178	0.055
low density lipoprotein receptor particle metabolic process	GO:0032799	4	0.055
granulocyte chemotaxis	GO:0071621	39	0.055
negative regulation of lymphocyte activation	GO:0051250	91	0.055
gliogenesis	GO:0042063	141	0.054
regulation of phospholipid catabolic process	GO:0060696	2	0.054
cellular metal ion homeostasis	GO:0006875	151	0.054
axis elongation involved in somitogenesis	GO:0090245	4	0.054
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.054
lung development	GO:0030324	164	0.053	Mouse
muscle cell differentiation	GO:0042692	261	0.053
interleukin 1 beta production	GO:0032611	30	0.053	Human
i kappab kinase nf kappab signaling	GO:0007249	85	0.053
sterol import	GO:0035376	2	0.053
stem cell development	GO:0048864	219	0.053
engulfment of apoptotic cell	GO:0043652	3	0.053	Mouse
regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO:2000161	1	0.052
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.052
acylglycerol biosynthetic process	GO:0046463	18	0.052
cellular response to steroid hormone stimulus	GO:0071383	33	0.052
dendrite development	GO:0016358	115	0.052
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.052	Human
t cell activation involved in immune response	GO:0002286	43	0.051
regulation of lymphocyte proliferation	GO:0050670	117	0.051
granulocyte migration	GO:0097530	43	0.051
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.051
pattern recognition receptor signaling pathway	GO:0002221	47	0.050
regulation of platelet derived growth factor receptor beta signaling pathway	GO:2000586	2	0.050
skeletal muscle organ development	GO:0060538	163	0.050
cerebral cortex development	GO:0021987	86	0.050
carbohydrate derivative catabolic process	GO:1901136	231	0.050	Mouse
regulation of amyloid precursor protein catabolic process	GO:1902991	8	0.050	Mouse
cellular response to organonitrogen compound	GO:0071417	145	0.050

Abca1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of metabolism	DOID:0014667	0.686	Human
inherited metabolic disorder	DOID:655	0.686	Human
retinal disease	DOID:5679	0.546
sensory system disease	DOID:0050155	0.546
disease of anatomical entity	DOID:7	0.546
eye and adnexa disease	DOID:1492	0.546
nervous system disease	DOID:863	0.546
eye disease	DOID:5614	0.546
retinal degeneration	DOID:8466	0.291
immune system disease	DOID:2914	0.226
lymphatic system disease	DOID:75	0.213
lipid storage disease	DOID:9455	0.170
lysosomal storage disease	DOID:3211	0.170
sphingolipidosis	DOID:1927	0.091
hemolytic anemia	DOID:583	0.056
hemolytic uremic syndrome	DOID:12554	0.056
normocytic anemia	DOID:720	0.056
anemia	DOID:2355	0.056
hematopoietic system disease	DOID:74	0.056

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