IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Ace2

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

(Aliases: 2010305L05Rik)

Ensembl: ENSMUSG00000015405
Entrez: 70008
UniProtKB: Q3URC9
UniProtKB: Q8R0I0

Process Predictions
Disease Predictions

Ace2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
vitamin transmembrane transport	GO:0035461	4	0.216
nitrogen compound transport	GO:0071705	271	0.108
ion transmembrane transport	GO:0034220	361	0.103
anion transport	GO:0006820	177	0.083
leukocyte differentiation	GO:0002521	342	0.083
amine metabolic process	GO:0009308	45	0.077
organic anion transport	GO:0015711	137	0.072
cellular lipid metabolic process	GO:0044255	323	0.072
sensory perception	GO:0007600	245	0.066
t cell activation	GO:0042110	289	0.066
cellular amino acid metabolic process	GO:0006520	103	0.064
hydrogen ion transmembrane transport	GO:1902600	25	0.063
response to organonitrogen compound	GO:0010243	246	0.061
cation transport	GO:0006812	399	0.058
peptidyl amino acid modification	GO:0018193	336	0.055
cellular amine metabolic process	GO:0044106	44	0.052
organic hydroxy compound metabolic process	GO:1901615	203	0.050
amino acid transmembrane transport	GO:0003333	37	0.049
renal system development	GO:0072001	225	0.048	Mouse
transmembrane transport	GO:0055085	412	0.048
anion transmembrane transport	GO:0098656	71	0.046
organonitrogen compound catabolic process	GO:1901565	264	0.043
positive regulation of protein phosphorylation	GO:0001934	242	0.042
oxidation reduction process	GO:0055114	342	0.042
stem cell development	GO:0048864	219	0.042
regulation of cellular amino acid metabolic process	GO:0006521	5	0.041
thiamine transport	GO:0015888	2	0.041
regulation of cytokine production	GO:0001817	266	0.041
nucleoside phosphate metabolic process	GO:0006753	338	0.036
embryonic organ morphogenesis	GO:0048562	276	0.036
lymphocyte differentiation	GO:0030098	242	0.035
cytokine production	GO:0001816	319	0.034
male gamete generation	GO:0048232	285	0.034	Mouse
regulation of t cell activation	GO:0050863	170	0.033
cellular ketone metabolic process	GO:0042180	84	0.033
cell maturation	GO:0048469	127	0.033
positive regulation of cellular amine metabolic process	GO:0033240	5	0.033
nucleotide metabolic process	GO:0009117	332	0.032
regulation of ph	GO:0006885	26	0.032
regulation of muscle tissue development	GO:1901861	97	0.032
regulation of t cell differentiation	GO:0045580	83	0.032
cellular nitrogen compound catabolic process	GO:0044270	280	0.032
hexose transmembrane transport	GO:0035428	7	0.032
organic acid transport	GO:0015849	101	0.031
regulation of lymphocyte activation	GO:0051249	240	0.031
purine containing compound metabolic process	GO:0072521	311	0.030
cell adhesion	GO:0007155	329	0.030
developmental maturation	GO:0021700	193	0.030
regulation of multi organism process	GO:0043900	111	0.030
peptide transport	GO:0015833	133	0.030
norepinephrine transport	GO:0015874	2	0.029
vitamin transport	GO:0051180	10	0.029
inter male aggressive behavior	GO:0002121	3	0.029
monocarboxylic acid metabolic process	GO:0032787	191	0.029
muscle cell differentiation	GO:0042692	261	0.028
kidney development	GO:0001822	213	0.028	Mouse
carbohydrate metabolic process	GO:0005975	230	0.028
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.028
oligopeptide transmembrane transport	GO:0035672	4	0.027
regulation of cell activation	GO:0050865	289	0.027
metal ion homeostasis	GO:0055065	189	0.026
cation transmembrane transport	GO:0098655	266	0.026
regulation of leukocyte differentiation	GO:1902105	159	0.026
body fluid secretion	GO:0007589	53	0.026
regulation of secretion	GO:0051046	274	0.026
compound eye development	GO:0048749	1	0.026
respiratory system development	GO:0060541	190	0.026
ribonucleoside catabolic process	GO:0042454	206	0.025
synaptic transmission	GO:0007268	329	0.025
pyrimidine containing compound transmembrane transport	GO:0072531	5	0.025
regulation of hormone levels	GO:0010817	211	0.025	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.025
sulfur compound transport	GO:0072348	9	0.025
regulation of cellular amine metabolic process	GO:0033238	20	0.025
nucleoside metabolic process	GO:0009116	246	0.025
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.025
regulation of lymphocyte differentiation	GO:0045619	107	0.025
lymphocyte activation involved in immune response	GO:0002285	93	0.024
urogenital system development	GO:0001655	261	0.024	Mouse
inorganic cation transmembrane transport	GO:0098662	207	0.024
nucleobase containing small molecule metabolic process	GO:0055086	352	0.024
carboxylic acid transport	GO:0046942	100	0.024
g protein coupled receptor signaling pathway	GO:0007186	243	0.023
pyridine nucleotide catabolic process	GO:0019364	3	0.023
membrane organization	GO:0061024	245	0.023
single organism cell adhesion	GO:0098602	156	0.023
leukocyte activation involved in immune response	GO:0002366	126	0.023
amide transport	GO:0042886	138	0.023
epithelial cell proliferation	GO:0050673	174	0.023
regulation of protein localization	GO:0032880	231	0.022
regulation of secretion by cell	GO:1903530	249	0.022
amino acid transport	GO:0006865	61	0.022
reactive oxygen species metabolic process	GO:0072593	84	0.022
epithelial tube morphogenesis	GO:0060562	303	0.022
inorganic anion transmembrane transport	GO:0098661	29	0.022
drug catabolic process	GO:0042737	2	0.022
embryonic epithelial tube formation	GO:0001838	130	0.022
regulation of body fluid levels	GO:0050878	162	0.022
regulation of neuron apoptotic process	GO:0043523	122	0.022
cellular protein complex assembly	GO:0043623	116	0.022
positive regulation of cell development	GO:0010720	237	0.022
organic cyclic compound catabolic process	GO:1901361	295	0.022
blood vessel morphogenesis	GO:0048514	285	0.022
ribonucleotide metabolic process	GO:0009259	291	0.021
negative regulation of cell proliferation	GO:0008285	296	0.021
tissue homeostasis	GO:0001894	115	0.021
negative regulation of protein metabolic process	GO:0051248	282	0.021
ras protein signal transduction	GO:0007265	77	0.021
regulation of cellular ketone metabolic process	GO:0010565	66	0.021
regulation of establishment of protein localization	GO:0070201	181	0.021
regulation of membrane potential	GO:0042391	192	0.021
regulation of cell projection organization	GO:0031344	206	0.021
regulation of cell cycle	GO:0051726	281	0.021
single organismal cell cell adhesion	GO:0016337	131	0.021
respiratory tube development	GO:0030323	167	0.020
neural tube development	GO:0021915	160	0.020
cation homeostasis	GO:0055080	212	0.020
embryonic placenta development	GO:0001892	98	0.020
multicellular organism growth	GO:0035264	161	0.020	Worm
gland development	GO:0048732	330	0.020
sulfate assimilation	GO:0000103	3	0.020
cell activation involved in immune response	GO:0002263	126	0.020
glycosyl compound metabolic process	GO:1901657	246	0.020
nucleoside phosphate catabolic process	GO:1901292	222	0.020
ribose phosphate metabolic process	GO:0019693	291	0.020
actin cytoskeleton organization	GO:0030036	220	0.019
nucleotide catabolic process	GO:0009166	217	0.019
placenta development	GO:0001890	140	0.019
posttranscriptional regulation of gene expression	GO:0010608	155	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.019
sensory organ morphogenesis	GO:0090596	242	0.019
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.019
organophosphate catabolic process	GO:0046434	232	0.019
heterocycle catabolic process	GO:0046700	280	0.019
purine nucleotide metabolic process	GO:0006163	302	0.019
spermatogenesis	GO:0007283	284	0.019	Mouse
inorganic anion transport	GO:0015698	43	0.018
response to lipopolysaccharide	GO:0032496	128	0.018
purine ribonucleoside metabolic process	GO:0046128	241	0.018
fatty acid metabolic process	GO:0006631	121	0.018
positive regulation of t cell activation	GO:0050870	101	0.018
regulation of organelle organization	GO:0033043	289	0.018
negative regulation of immune system process	GO:0002683	209	0.018
negative regulation of cellular component organization	GO:0051129	194	0.018
digestive system development	GO:0055123	200	0.018
positive regulation of leukocyte differentiation	GO:1902107	86	0.018
stem cell differentiation	GO:0048863	268	0.018
angiogenesis	GO:0001525	201	0.018
inorganic ion transmembrane transport	GO:0098660	234	0.018
purine ribonucleotide metabolic process	GO:0009150	290	0.018
regulation of hydrolase activity	GO:0051336	246	0.018
regulation of cellular catabolic process	GO:0031329	242	0.018
response to inorganic substance	GO:0010035	96	0.018
dephosphorylation	GO:0016311	129	0.018
negative regulation of phosphate metabolic process	GO:0045936	184	0.018
response to organic cyclic compound	GO:0014070	198	0.018
development of primary sexual characteristics	GO:0045137	143	0.018	Worm
positive regulation of lymphocyte activation	GO:0051251	140	0.018
positive regulation of secretion	GO:0051047	130	0.017
mitotic cytokinesis	GO:0000281	4	0.017
steroid metabolic process	GO:0008202	119	0.017
epithelial cell development	GO:0002064	159	0.017
cellular response to growth factor stimulus	GO:0071363	197	0.017
gonad development	GO:0008406	141	0.017	Worm
negative regulation of multi organism process	GO:0043901	68	0.017
cytokine mediated signaling pathway	GO:0019221	115	0.017
immune response regulating signaling pathway	GO:0002764	125	0.017
positive regulation of apoptotic process	GO:0043065	217	0.017
cellular amide metabolic process	GO:0043603	58	0.017
chloride transmembrane transport	GO:1902476	24	0.016
homeostasis of number of cells	GO:0048872	210	0.016
mesenchyme development	GO:0060485	152	0.016
positive regulation of defense response	GO:0031349	124	0.016
inflammatory response	GO:0006954	244	0.016
nucleoside triphosphate metabolic process	GO:0009141	230	0.016
striated muscle tissue development	GO:0014706	293	0.016
regulation of norepinephrine secretion	GO:0014061	2	0.016
neuron death	GO:0070997	154	0.016
nucleoside triphosphate catabolic process	GO:0009143	205	0.015
regulation of neuron differentiation	GO:0045664	281	0.015
negative regulation of epithelial cell proliferation	GO:0050680	64	0.015
aromatic compound catabolic process	GO:0019439	286	0.015
cellular response to dna damage stimulus	GO:0006974	207	0.015
positive regulation of protein modification process	GO:0031401	299	0.015
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.015
response to drug	GO:0042493	75	0.015
regulation of renal sodium excretion	GO:0035813	3	0.015
blood circulation	GO:0008015	195	0.015	Mouse Fly
blastocyst development	GO:0001824	80	0.015
actin filament polymerization	GO:0030041	44	0.015
regulation of inflammatory response	GO:0050727	147	0.015
ribonucleoside metabolic process	GO:0009119	245	0.015
response to growth factor	GO:0070848	198	0.015
myeloid cell homeostasis	GO:0002262	114	0.015
transepithelial chloride transport	GO:0030321	4	0.015
lipid localization	GO:0010876	126	0.015
locomotory behavior	GO:0007626	195	0.015
cellular response to cytokine stimulus	GO:0071345	189	0.015
cellular homeostasis	GO:0019725	240	0.015
carbohydrate derivative catabolic process	GO:1901136	231	0.015
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.015
regulation of cell growth	GO:0001558	91	0.015
positive regulation of cell death	GO:0010942	224	0.015
positive regulation of programmed cell death	GO:0043068	218	0.015
glucose transport	GO:0015758	56	0.015
purine ribonucleoside catabolic process	GO:0046130	205	0.015
multicellular organismal signaling	GO:0035637	91	0.015
myosin filament assembly	GO:0031034	2	0.014
epithelial tube formation	GO:0072175	130	0.014
regulation of endopeptidase activity	GO:0052548	89	0.014
purine nucleotide catabolic process	GO:0006195	211	0.014
skeletal system development	GO:0001501	356	0.014
nucleoside catabolic process	GO:0009164	206	0.014
morphogenesis of embryonic epithelium	GO:0016331	159	0.014
neuron apoptotic process	GO:0051402	142	0.014
regulation of defense response to bacterium	GO:1900424	3	0.014
negative regulation of cellular protein metabolic process	GO:0032269	247	0.014
response to light stimulus	GO:0009416	135	0.014
mapk cascade	GO:0000165	281	0.014
fertilization	GO:0009566	127	0.014
monocarboxylic acid biosynthetic process	GO:0072330	61	0.014
d amino acid transport	GO:0042940	1	0.014
mitotic cell cycle	GO:0000278	195	0.014
positive regulation of lymphocyte differentiation	GO:0045621	61	0.014
anatomical structure homeostasis	GO:0060249	145	0.014
purine nucleoside catabolic process	GO:0006152	205	0.014
negative regulation of protein phosphorylation	GO:0001933	126	0.014
sphingolipid metabolic process	GO:0006665	45	0.014
hormone metabolic process	GO:0042445	86	0.014	Mouse
positive regulation of t cell differentiation	GO:0045582	52	0.014
digestive tract development	GO:0048565	190	0.013
regulation of cell adhesion	GO:0030155	154	0.013
negative regulation of cell development	GO:0010721	169	0.013
skeletal muscle organ development	GO:0060538	163	0.013
multicellular organismal homeostasis	GO:0048871	164	0.013
monovalent inorganic cation homeostasis	GO:0055067	33	0.013
cellular response to organonitrogen compound	GO:0071417	145	0.013
carboxylic acid biosynthetic process	GO:0046394	86	0.013
organic hydroxy compound transport	GO:0015850	93	0.013
positive regulation of hydrolase activity	GO:0051345	148	0.013
morphogenesis of a branching structure	GO:0001763	203	0.013
regulation of peptidase activity	GO:0052547	96	0.013
forebrain development	GO:0030900	302	0.013
regulation of proteolysis	GO:0030162	164	0.013
organic acid biosynthetic process	GO:0016053	86	0.013
cellular response to lipopolysaccharide	GO:0071222	77	0.013
cell growth	GO:0016049	130	0.013
negative regulation of molecular function	GO:0044092	258	0.013
regulation of reproductive process	GO:2000241	66	0.013
purine containing compound catabolic process	GO:0072523	213	0.013
cell type specific apoptotic process	GO:0097285	268	0.013
glycosyl compound catabolic process	GO:1901658	206	0.013
purine ribonucleotide catabolic process	GO:0009154	208	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.013
cellular response to oxidative stress	GO:0034599	76	0.013
divalent inorganic cation homeostasis	GO:0072507	138	0.013
regulation of epithelial cell proliferation	GO:0050678	141	0.013
regulation of defense response	GO:0031347	233	0.012
purine nucleoside metabolic process	GO:0042278	241	0.012
small gtpase mediated signal transduction	GO:0007264	97	0.012
adult behavior	GO:0030534	135	0.012
regulation of cellular component biogenesis	GO:0044087	181	0.012
negative regulation of protein modification process	GO:0031400	163	0.012
regulation of neuron projection development	GO:0010975	169	0.012
mesenchymal cell development	GO:0014031	93	0.012
regulation of binding	GO:0051098	111	0.012
negative regulation of phosphorus metabolic process	GO:0010563	184	0.012
hexose transport	GO:0008645	56	0.012
positive regulation of cellular catabolic process	GO:0031331	148	0.012
regulation of purine nucleotide metabolic process	GO:1900542	169	0.012
tube formation	GO:0035148	140	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.012
myeloid cell differentiation	GO:0030099	233	0.012
actin filament based movement	GO:0030048	23	0.012
skin development	GO:0043588	220	0.012
cellular response to acid chemical	GO:0071229	68	0.012
myotube differentiation	GO:0014902	105	0.012
response to extracellular stimulus	GO:0009991	127	0.012
mitotic cell cycle process	GO:1903047	159	0.012
leukocyte proliferation	GO:0070661	172	0.012
t cell apoptotic process	GO:0070231	39	0.012
t cell differentiation	GO:0030217	174	0.012
response to sterol	GO:0036314	4	0.012
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.012
response to radiation	GO:0009314	165	0.012
engulfment of apoptotic cell	GO:0043652	3	0.012
membrane lipid metabolic process	GO:0006643	53	0.012
negative regulation of cellular amine metabolic process	GO:0033239	1	0.012
regulation of lymphocyte proliferation	GO:0050670	117	0.012
positive regulation of transferase activity	GO:0051347	167	0.012
neuromuscular process	GO:0050905	99	0.012
peptidyl tyrosine modification	GO:0018212	145	0.012
positive regulation of cell activation	GO:0050867	158	0.011
retrograde transport endosome to golgi	GO:0042147	2	0.011
ribonucleotide catabolic process	GO:0009261	208	0.011
stem cell proliferation	GO:0072089	117	0.011
regulation of neuron death	GO:1901214	134	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.011
alpha beta t cell activation	GO:0046631	91	0.011
regulation of transferase activity	GO:0051338	263	0.011
regulation of receptor activity	GO:0010469	41	0.011
positive regulation of neuron differentiation	GO:0045666	141	0.011
b cell activation	GO:0042113	161	0.011
actin filament organization	GO:0007015	113	0.011
mitochondrion organization	GO:0007005	134	0.011
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.011
response to molecule of bacterial origin	GO:0002237	143	0.011
regulation of protein transport	GO:0051223	163	0.011
myosin filament organization	GO:0031033	3	0.011
microtubule based process	GO:0007017	236	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.011
small molecule biosynthetic process	GO:0044283	132	0.011
response to mineralocorticoid	GO:0051385	1	0.011
negative regulation of phosphorylation	GO:0042326	166	0.011
wound healing	GO:0042060	157	0.011
drug metabolic process	GO:0017144	4	0.011
chemotaxis	GO:0006935	247	0.011
maintenance of location	GO:0051235	89	0.011
sterol homeostasis	GO:0055092	45	0.011
peptide hormone secretion	GO:0030072	109	0.011
sensory organ boundary specification	GO:0008052	1	0.011
rho protein signal transduction	GO:0007266	32	0.011
positive regulation of growth	GO:0045927	104	0.011	Worm
organonitrogen compound biosynthetic process	GO:1901566	192	0.011
cellular carbohydrate metabolic process	GO:0044262	119	0.011
intestinal absorption	GO:0050892	13	0.011
midgut development	GO:0007494	4	0.011
response to peptide	GO:1901652	136	0.010
mesenchymal cell differentiation	GO:0048762	107	0.010
cell growth involved in cardiac muscle cell development	GO:0061049	3	0.010
leukocyte homeostasis	GO:0001776	79	0.010
regulation of cell motility	GO:2000145	236	0.010
neural tube formation	GO:0001841	108	0.010
macromolecule catabolic process	GO:0009057	281	0.010
response to transforming growth factor beta	GO:0071559	88	0.010
apoptotic signaling pathway	GO:0097190	306	0.010
protein modification by small protein conjugation	GO:0032446	187	0.010
lateral inhibition	GO:0046331	1	0.010
mammary gland epithelium development	GO:0061180	65	0.010
oocyte construction	GO:0007308	2	0.010
lung development	GO:0030324	164	0.010
neuronal action potential	GO:0019228	54	0.010
regulation of leukocyte proliferation	GO:0070663	121	0.010
gtp catabolic process	GO:0006184	143	0.010
positive regulation of proteolysis	GO:0045862	85	0.010
adult locomotory behavior	GO:0008344	91	0.010
lymphocyte proliferation	GO:0046651	164	0.010

Ace2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
respiratory system disease	DOID:1579	0.053
lower respiratory tract disease	DOID:0050161	0.053
disease of anatomical entity	DOID:7	0.053
nervous system disease	DOID:863	0.014
cancer	DOID:162	0.013
disease of cellular proliferation	DOID:14566	0.013
organ system cancer	DOID:0050686	0.013
connective tissue disease	DOID:65	0.012
musculoskeletal system disease	DOID:17	0.012
bone disease	DOID:0080001	0.011

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network