IMP: Integrative Multi-species Prediction

Mus musculus

76 known processes

Ache

acetylcholinesterase

(Aliases: mE1a,mE1c-long,mE1c,mE1b,mE1e,mE1d,mE1d')

Ensembl: ENSMUSG00000023328
Entrez: 11423
UniProtKB: Q543Z1
UniProtKB: P21836

Process Predictions
Disease Predictions

Ache biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ion transmembrane transport	GO:0034220	361	0.974
acetylcholine secretion neurotransmission	GO:0014055	2	0.855
cation transport	GO:0006812	399	0.845
regulation of ion transport	GO:0043269	215	0.818
regulation of dopamine secretion	GO:0014059	9	0.801
transmembrane transport	GO:0055085	412	0.752
norepinephrine transport	GO:0015874	2	0.733
regulation of heart contraction	GO:0008016	77	0.620
regulation of system process	GO:0044057	200	0.607
regulation of acetylcholine secretion neurotransmission	GO:0014056	2	0.607
heart contraction	GO:0060047	93	0.558
circulatory system process	GO:0003013	197	0.536
regulation of catecholamine secretion	GO:0050433	12	0.531
cation transmembrane transport	GO:0098655	266	0.527
regulation of transmembrane transport	GO:0034762	128	0.516
activation of transmembrane receptor protein tyrosine kinase activity	GO:0007171	3	0.498
muscle tissue development	GO:0060537	308	0.475
catecholamine secretion	GO:0050432	15	0.475
muscle system process	GO:0003012	141	0.458
muscle contraction	GO:0006936	101	0.452
striated muscle contraction	GO:0006941	45	0.448
inorganic ion transmembrane transport	GO:0098660	234	0.436
sensory perception of light stimulus	GO:0050953	54	0.435
regulation of metal ion transport	GO:0010959	106	0.434
cytokine production	GO:0001816	319	0.394
divalent inorganic cation transport	GO:0072511	178	0.392
dopamine secretion	GO:0014046	9	0.384
membrane depolarization	GO:0051899	64	0.382
positive regulation of dopamine secretion	GO:0033603	2	0.378
membrane organization	GO:0061024	245	0.374
regulation of muscle contraction	GO:0006937	49	0.364
circadian sleep wake cycle rem sleep	GO:0042747	1	0.360
acetylcholine transport	GO:0015870	2	0.347
regulation of ion transmembrane transport	GO:0034765	119	0.341
positive regulation of catecholamine secretion	GO:0033605	2	0.340
regulation of circadian sleep wake cycle	GO:0042749	3	0.330
calcium ion transport	GO:0006816	159	0.330
sensory perception	GO:0007600	245	0.329
carbohydrate derivative catabolic process	GO:1901136	231	0.325
positive regulation of secretion by cell	GO:1903532	114	0.299
divalent metal ion transport	GO:0070838	172	0.295
heart process	GO:0003015	94	0.275
regulation of circadian sleep wake cycle rem sleep	GO:0042320	1	0.271
visual perception	GO:0007601	52	0.269
inorganic cation transmembrane transport	GO:0098662	207	0.263
regulation of circadian sleep wake cycle sleep	GO:0045187	3	0.262
action potential	GO:0001508	78	0.261
regulation of neurotransmitter transport	GO:0051588	35	0.249
regulation of blood circulation	GO:1903522	93	0.241
striated muscle tissue development	GO:0014706	293	0.240
synaptic transmission	GO:0007268	329	0.235
microtubule based process	GO:0007017	236	0.229
response to lipopolysaccharide	GO:0032496	128	0.228
regulation of cardiac muscle contraction	GO:0055117	21	0.227
amine transport	GO:0015837	21	0.226
organic hydroxy compound transport	GO:0015850	93	0.224
regulation of blood pressure	GO:0008217	93	0.224
regulation of feeding behavior	GO:0060259	3	0.215
axonogenesis	GO:0007409	274	0.215
protein localization to membrane	GO:0072657	108	0.214
regulation of cell projection organization	GO:0031344	206	0.211
regulation of protein kinase activity	GO:0045859	232	0.211
cellular amine metabolic process	GO:0044106	44	0.208	Fly
positive regulation of ion transport	GO:0043270	65	0.207
regulation of muscle system process	GO:0090257	80	0.207
muscle cell differentiation	GO:0042692	261	0.202	Zebrafish
regulation of heart rate	GO:0002027	36	0.200
long term synaptic potentiation	GO:0060291	25	0.198
cellular amino acid metabolic process	GO:0006520	103	0.198
blood circulation	GO:0008015	195	0.198
generation of ovulation cycle rhythm	GO:0060112	1	0.198
synaptic transmission involved in micturition	GO:0060084	3	0.196
multi multicellular organism process	GO:0044706	109	0.195
camera type eye development	GO:0043010	266	0.195
circadian sleep wake cycle non rem sleep	GO:0042748	2	0.193
cellular response to growth factor stimulus	GO:0071363	197	0.192
regulation of cell motility	GO:2000145	236	0.190
positive regulation of protein phosphorylation	GO:0001934	242	0.189
skeletal system development	GO:0001501	356	0.183
regulation of membrane potential	GO:0042391	192	0.183
regulation of cell migration	GO:0030334	219	0.181
positive regulation of secretion	GO:0051047	130	0.180
conditioned taste aversion	GO:0001661	4	0.179
regulation of amine transport	GO:0051952	21	0.179
purine ribonucleoside metabolic process	GO:0046128	241	0.178
regulation of secretion	GO:0051046	274	0.178
regulation of cellular amine metabolic process	GO:0033238	20	0.177
cellular lipid metabolic process	GO:0044255	323	0.171	Mouse
acetate ester transport	GO:1901374	2	0.167
organonitrogen compound catabolic process	GO:1901565	264	0.167	Mouse Fly
nucleoside phosphate catabolic process	GO:1901292	222	0.167
regulation of transferase activity	GO:0051338	263	0.167
microtubule cytoskeleton organization	GO:0000226	157	0.155
regulation of systemic arterial blood pressure	GO:0003073	61	0.151
nucleobase containing small molecule metabolic process	GO:0055086	352	0.150
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.148
amino acid transport	GO:0006865	61	0.146
regulation of circadian sleep wake cycle non rem sleep	GO:0045188	1	0.145
norepinephrine secretion	GO:0048243	2	0.145
negative regulation of cellular protein metabolic process	GO:0032269	247	0.145
synapse organization	GO:0050808	125	0.144	Zebrafish
nucleoside triphosphate metabolic process	GO:0009141	230	0.142
regulation of sodium ion transmembrane transport	GO:1902305	9	0.141
organophosphate catabolic process	GO:0046434	232	0.138
cellular nitrogen compound catabolic process	GO:0044270	280	0.138
organelle assembly	GO:0070925	177	0.136	Zebrafish
calcium ion transmembrane transport	GO:0070588	85	0.136
response to nicotine	GO:0035094	6	0.134
regulation of calcium ion transport	GO:0051924	69	0.133
nucleoside metabolic process	GO:0009116	246	0.133
cytoskeleton dependent intracellular transport	GO:0030705	50	0.132
purine containing compound metabolic process	GO:0072521	311	0.132
regulation of norepinephrine secretion	GO:0014061	2	0.130
regulation of cellular component size	GO:0032535	121	0.129
nucleoside phosphate metabolic process	GO:0006753	338	0.129
response to oxygen levels	GO:0070482	62	0.129
regulation of neuron differentiation	GO:0045664	281	0.128
respiratory tube development	GO:0030323	167	0.128
cardiac muscle contraction	GO:0060048	32	0.128
regulation of neurotransmitter levels	GO:0001505	87	0.128
fat cell differentiation	GO:0045444	160	0.125
regulation of excitatory postsynaptic membrane potential	GO:0060079	41	0.124
positive regulation of cellular amine metabolic process	GO:0033240	5	0.124
fatty acid metabolic process	GO:0006631	121	0.123	Mouse
aromatic compound catabolic process	GO:0019439	286	0.121
developmental cell growth	GO:0048588	84	0.121
response to organonitrogen compound	GO:0010243	246	0.121	Zebrafish
monoamine transport	GO:0015844	33	0.120
regulation of neuron projection development	GO:0010975	169	0.120
ear development	GO:0043583	200	0.120
nucleoside triphosphate catabolic process	GO:0009143	205	0.118
ribonucleotide metabolic process	GO:0009259	291	0.117
negative regulation of cellular component organization	GO:0051129	194	0.116
skeletal muscle fiber development	GO:0048741	58	0.115
regulation of cytokine production	GO:0001817	266	0.114
muscle cell development	GO:0055001	133	0.114	Zebrafish
amine metabolic process	GO:0009308	45	0.113	Fly
purine ribonucleotide catabolic process	GO:0009154	208	0.107
response to molecule of bacterial origin	GO:0002237	143	0.106
regulation of secretion by cell	GO:1903530	249	0.104
relaxation of muscle	GO:0090075	18	0.104
astrocyte differentiation	GO:0048708	43	0.104
regulation of postsynaptic membrane potential	GO:0060078	48	0.104
t cell activation	GO:0042110	289	0.102
ribonucleoside metabolic process	GO:0009119	245	0.101
nucleotide metabolic process	GO:0009117	332	0.100
cellular chemical homeostasis	GO:0055082	215	0.100
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.100
actin cytoskeleton organization	GO:0030036	220	0.099	Zebrafish
intracellular protein transport	GO:0006886	204	0.098
membrane hyperpolarization	GO:0060081	21	0.096
purine ribonucleotide metabolic process	GO:0009150	290	0.096
response to organic cyclic compound	GO:0014070	198	0.095
organic cyclic compound catabolic process	GO:1901361	295	0.093
catecholamine metabolic process	GO:0006584	30	0.093
axon cargo transport	GO:0008088	33	0.092
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.091
positive regulation of sodium ion transmembrane transport	GO:1902307	4	0.091
lateral geniculate nucleus development	GO:0021771	1	0.090
cellular protein complex assembly	GO:0043623	116	0.090
myotube differentiation	GO:0014902	105	0.089
glycosyl compound metabolic process	GO:1901657	246	0.089
regulation of striated muscle contraction	GO:0006942	25	0.088
regulation of ion homeostasis	GO:2000021	64	0.087
neurotransmitter transport	GO:0006836	76	0.087
nucleotide catabolic process	GO:0009166	217	0.087
purine nucleotide metabolic process	GO:0006163	302	0.087
plasma membrane organization	GO:0007009	90	0.085
cell type specific apoptotic process	GO:0097285	268	0.085
peptidyl amino acid modification	GO:0018193	336	0.085
embryonic organ morphogenesis	GO:0048562	276	0.084
negative regulation of hydrolase activity	GO:0051346	71	0.084
positive regulation of heart contraction	GO:0045823	14	0.084
response to radiation	GO:0009314	165	0.083	Fly
regulation of body fluid levels	GO:0050878	162	0.083
multi organism behavior	GO:0051705	62	0.082
positive regulation of protein kinase activity	GO:0045860	144	0.082
multicellular organism growth	GO:0035264	161	0.082
ventricular cardiac muscle cell action potential	GO:0086005	4	0.081
negative regulation of cell development	GO:0010721	169	0.081
purine ribonucleoside catabolic process	GO:0046130	205	0.080
neuron death	GO:0070997	154	0.080
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.080
detection of external stimulus	GO:0009581	61	0.079
oxidation reduction process	GO:0055114	342	0.078
regulation of kinase activity	GO:0043549	249	0.078
purine nucleoside metabolic process	GO:0042278	241	0.077
organic anion transport	GO:0015711	137	0.077
positive regulation of cell projection organization	GO:0031346	95	0.076
protein maturation	GO:0051604	176	0.076
regulation of hormone levels	GO:0010817	211	0.076
ribonucleotide catabolic process	GO:0009261	208	0.075
protein processing	GO:0016485	163	0.075
positive regulation of transferase activity	GO:0051347	167	0.075
detection of light stimulus	GO:0009583	25	0.075
baroreceptor response to decreased systemic arterial blood pressure	GO:0001982	2	0.075
skeletal muscle organ development	GO:0060538	163	0.074
regulation of muscle tissue development	GO:1901861	97	0.073
endomembrane system organization	GO:0010256	147	0.072
dopamine metabolic process	GO:0042417	23	0.071
regulation of neurotransmitter uptake	GO:0051580	6	0.071
ribonucleoside catabolic process	GO:0042454	206	0.071
calcium mediated signaling	GO:0019722	46	0.071
negative regulation of phosphorylation	GO:0042326	166	0.070
positive regulation of sodium ion transport	GO:0010765	13	0.070
ribose phosphate metabolic process	GO:0019693	291	0.070
dopamine transport	GO:0015872	15	0.070
reproductive behavior	GO:0019098	32	0.070
regulation of cell activation	GO:0050865	289	0.070
regulation of dopamine metabolic process	GO:0042053	10	0.069
negative regulation of nervous system development	GO:0051961	156	0.069
purine nucleoside catabolic process	GO:0006152	205	0.069
cellular ketone metabolic process	GO:0042180	84	0.069
negative regulation of protein metabolic process	GO:0051248	282	0.068
smooth muscle contraction	GO:0006939	44	0.067
brown fat cell differentiation	GO:0050873	36	0.067
immune effector process	GO:0002252	321	0.067
nitrogen compound transport	GO:0071705	271	0.066
regulation of protein serine threonine kinase activity	GO:0071900	157	0.066
extracellular matrix organization	GO:0030198	147	0.066
monosaccharide metabolic process	GO:0005996	106	0.066
protein polymerization	GO:0051258	57	0.066
negative regulation of neuron death	GO:1901215	98	0.066
peptidyl serine modification	GO:0018209	83	0.066
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.065
neuromuscular process	GO:0050905	99	0.065
homeostasis of number of cells	GO:0048872	210	0.065
regulation of cellular amino acid metabolic process	GO:0006521	5	0.064
regulation of sodium ion transport	GO:0002028	29	0.064
regulation of anatomical structure size	GO:0090066	178	0.063
positive regulation of ion transmembrane transporter activity	GO:0032414	15	0.063
nucleoside catabolic process	GO:0009164	206	0.062
cellular ion homeostasis	GO:0006873	165	0.062
feeding behavior	GO:0007631	62	0.062
sperm motility	GO:0030317	47	0.061
anatomical structure homeostasis	GO:0060249	145	0.061
erk1 and erk2 cascade	GO:0070371	77	0.061
establishment of protein localization to membrane	GO:0090150	54	0.061
regulation of hydrolase activity	GO:0051336	246	0.060
regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback	GO:0001978	5	0.060
negative regulation of molecular function	GO:0044092	258	0.060
catecholamine transport	GO:0051937	21	0.059
microtubule based movement	GO:0007018	84	0.059
regulation of proteolysis	GO:0030162	164	0.059
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	GO:0001988	1	0.059
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.059
positive regulation of necrotic cell death	GO:0010940	1	0.058
organic hydroxy compound metabolic process	GO:1901615	203	0.058	Fly
phenol containing compound metabolic process	GO:0018958	60	0.058
negative regulation of phosphorus metabolic process	GO:0010563	184	0.057
regulation of cellular component biogenesis	GO:0044087	181	0.057
regulation of calcium ion transmembrane transport	GO:1903169	20	0.057
organelle localization	GO:0051640	179	0.057
regulation of smooth muscle contraction	GO:0006940	22	0.056
monocarboxylic acid metabolic process	GO:0032787	191	0.056	Mouse
g protein coupled receptor signaling pathway	GO:0007186	243	0.056
muscle fiber development	GO:0048747	76	0.055
glycosyl compound catabolic process	GO:1901658	206	0.055
regulation of homeostatic process	GO:0032844	182	0.055
transmission of nerve impulse	GO:0019226	76	0.055
regulation of intracellular transport	GO:0032386	159	0.055
response to inactivity	GO:0014854	4	0.055
regulation of organelle organization	GO:0033043	289	0.054
negative regulation of phosphate metabolic process	GO:0045936	184	0.054
purine nucleotide catabolic process	GO:0006195	211	0.053
rho protein signal transduction	GO:0007266	32	0.053
protein secretion	GO:0009306	111	0.052
actin filament organization	GO:0007015	113	0.052
cellular potassium ion transport	GO:0071804	43	0.052
positive regulation of cell death	GO:0010942	224	0.052
positive regulation of cell motility	GO:2000147	116	0.052
extracellular structure organization	GO:0043062	148	0.052
behavioral response to nutrient	GO:0051780	1	0.051
adult locomotory behavior	GO:0008344	91	0.051
regulation of establishment of protein localization	GO:0070201	181	0.051
anion transport	GO:0006820	177	0.050
regulation of mapk cascade	GO:0043408	248	0.050
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.050
multi organism reproductive behavior	GO:0044705	29	0.050
epithelial cell development	GO:0002064	159	0.050
negative regulation of neuron apoptotic process	GO:0043524	92	0.050
negative regulation of protein modification process	GO:0031400	163	0.050
glycerolipid metabolic process	GO:0046486	122	0.050	Mouse
protein localization to plasma membrane	GO:0072659	57	0.049
organ growth	GO:0035265	117	0.049
apoptotic signaling pathway	GO:0097190	306	0.049
myeloid cell homeostasis	GO:0002262	114	0.048
establishment of organelle localization	GO:0051656	122	0.048
response to peptide	GO:1901652	136	0.048
cardiac muscle tissue development	GO:0048738	130	0.048
neuron projection extension	GO:1990138	64	0.048
lipid modification	GO:0030258	65	0.047
regulation of cellular catabolic process	GO:0031329	242	0.047
negative regulation of immune system process	GO:0002683	209	0.047
negative regulation of intracellular signal transduction	GO:1902532	167	0.047
neurotransmitter secretion	GO:0007269	62	0.047
circadian sleep wake cycle	GO:0042745	5	0.046
cellular calcium ion homeostasis	GO:0006874	119	0.046
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.046
regulation of interleukin 1 production	GO:0032652	26	0.046
microtubule based transport	GO:0010970	50	0.046
positive regulation of heart rate	GO:0010460	10	0.046
muscle adaptation	GO:0043500	39	0.046
leukocyte proliferation	GO:0070661	172	0.046
locomotory behavior	GO:0007626	195	0.045
response to light stimulus	GO:0009416	135	0.045	Fly
regulation of calcium ion transmembrane transporter activity	GO:1901019	20	0.045
divalent inorganic cation homeostasis	GO:0072507	138	0.045
positive regulation of cell activation	GO:0050867	158	0.045
glial cell development	GO:0021782	54	0.045
purine containing compound catabolic process	GO:0072523	213	0.045
regulation of neuron death	GO:1901214	134	0.045
macromolecule catabolic process	GO:0009057	281	0.044
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:0014808	12	0.044
guanosine containing compound metabolic process	GO:1901068	144	0.044
positive regulation of amine transport	GO:0051954	8	0.044
potassium ion transport	GO:0006813	52	0.044
cation homeostasis	GO:0055080	212	0.044
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.043
negative regulation of calcium ion transmembrane transporter activity	GO:1901020	1	0.043
striated muscle cell development	GO:0055002	125	0.043	Zebrafish
positive regulation of mapk cascade	GO:0043410	170	0.043
cellular homeostasis	GO:0019725	240	0.042
single organismal cell cell adhesion	GO:0016337	131	0.042
potassium ion transmembrane transport	GO:0071805	43	0.042
guanosine containing compound catabolic process	GO:1901069	144	0.042
synapse assembly	GO:0007416	56	0.042
glycoprotein metabolic process	GO:0009100	116	0.042
membrane tubulation	GO:0097320	4	0.041
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:0010880	10	0.041
adult behavior	GO:0030534	135	0.041
peripheral nervous system axon regeneration	GO:0014012	2	0.041
regulation of protein processing	GO:0070613	96	0.041
dopamine uptake	GO:0090494	4	0.041
regulation of cellular ketone metabolic process	GO:0010565	66	0.041
b cell proliferation	GO:0042100	53	0.041
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.041
asymmetric stem cell division	GO:0098722	3	0.041
regulation of erk1 and erk2 cascade	GO:0070372	71	0.041
positive regulation of ion transmembrane transport	GO:0034767	24	0.040
retina development in camera type eye	GO:0060041	119	0.040
central nervous system neuron differentiation	GO:0021953	162	0.040
regulation of protein localization	GO:0032880	231	0.040
cellular response to molecule of bacterial origin	GO:0071219	83	0.040
cardiac muscle cell differentiation	GO:0055007	69	0.039
negative regulation of neuron projection development	GO:0010977	50	0.039
positive regulation of cell development	GO:0010720	237	0.039
body fluid secretion	GO:0007589	53	0.039
sequestering of metal ion	GO:0051238	19	0.039
positive regulation of potassium ion transport	GO:0043268	3	0.038
negative regulation of cell projection organization	GO:0031345	56	0.038
regulation of transporter activity	GO:0032409	57	0.038
organic acid transport	GO:0015849	101	0.038
regulation of systemic arterial blood pressure by baroreceptor feedback	GO:0003025	7	0.038
regulation of ion transmembrane transporter activity	GO:0032412	54	0.038
response to hypoxia	GO:0001666	58	0.038
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.038
second messenger mediated signaling	GO:0019932	73	0.038
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.038
regulation of glutamate secretion	GO:0014048	3	0.038
glial cell differentiation	GO:0010001	131	0.037
male gamete generation	GO:0048232	285	0.037
response to decreased oxygen levels	GO:0036293	59	0.037
actin filament polymerization	GO:0030041	44	0.037
release of sequestered calcium ion into cytosol	GO:0051209	42	0.037
regulation of lymphocyte activation	GO:0051249	240	0.037
lymphocyte proliferation	GO:0046651	164	0.036
regulation of skeletal muscle fiber development	GO:0048742	36	0.036
dna metabolic process	GO:0006259	303	0.036
gliogenesis	GO:0042063	141	0.036
lung development	GO:0030324	164	0.036
generation of precursor metabolites and energy	GO:0006091	103	0.036
nucleoside monophosphate metabolic process	GO:0009123	85	0.036
negative regulation of ion transport	GO:0043271	28	0.036
cellular response to lipid	GO:0071396	145	0.036
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.035
detection of abiotic stimulus	GO:0009582	60	0.035
maintenance of presynaptic active zone structure	GO:0048790	1	0.035
cell division	GO:0051301	120	0.035
cell substrate adhesion	GO:0031589	130	0.035
regulation of purine nucleotide metabolic process	GO:1900542	169	0.035
posttranscriptional regulation of gene expression	GO:0010608	155	0.035
cellular amide metabolic process	GO:0043603	58	0.034
peripheral nervous system development	GO:0007422	53	0.034
regulation of vesicle mediated transport	GO:0060627	139	0.034
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.034
mapk cascade	GO:0000165	281	0.034
myotube cell development	GO:0014904	60	0.034
renal system process	GO:0003014	48	0.034
negative regulation of cellular amine metabolic process	GO:0033239	1	0.034
regulation of axon extension	GO:0030516	43	0.033
response to growth factor	GO:0070848	198	0.033
male sex differentiation	GO:0046661	109	0.033
chemotaxis	GO:0006935	247	0.033
regulation of dopamine uptake involved in synaptic transmission	GO:0051584	2	0.033
cellular response to oxidative stress	GO:0034599	76	0.033
blood vessel morphogenesis	GO:0048514	285	0.033
camp metabolic process	GO:0046058	40	0.033
wound healing	GO:0042060	157	0.033
regulation of cell shape	GO:0008360	39	0.033
neural nucleus development	GO:0048857	22	0.033
myoblast differentiation	GO:0045445	52	0.033
regulation of schwann cell proliferation	GO:0010624	2	0.032
carbohydrate biosynthetic process	GO:0016051	74	0.032
neurofilament cytoskeleton organization	GO:0060052	10	0.032
positive regulation of gtp catabolic process	GO:0033126	85	0.032
synaptic vesicle localization	GO:0097479	59	0.032
cell maturation	GO:0048469	127	0.032
negative regulation of cell motility	GO:2000146	61	0.031
regulation of cytoskeleton organization	GO:0051493	122	0.031
protein targeting	GO:0006605	143	0.031
regulation of map kinase activity	GO:0043405	120	0.031
regulation of neurotransmitter secretion	GO:0046928	29	0.031
negative regulation of cell proliferation	GO:0008285	296	0.031
sensory organ morphogenesis	GO:0090596	242	0.031
regulation of gtp catabolic process	GO:0033124	113	0.031
positive regulation of protein transport	GO:0051222	93	0.030
schwann cell differentiation	GO:0014037	26	0.030
negative regulation of action potential	GO:0045759	1	0.030
ras protein signal transduction	GO:0007265	77	0.030
cytoplasmic transport	GO:0016482	234	0.030
intermediate filament cytoskeleton organization	GO:0045104	26	0.030
positive regulation of potassium ion transmembrane transport	GO:1901381	3	0.030
atp metabolic process	GO:0046034	75	0.030
response to food	GO:0032094	17	0.030
establishment of protein localization to plasma membrane	GO:0090002	34	0.030
regulation of cell adhesion	GO:0030155	154	0.030
positive regulation of nucleotide catabolic process	GO:0030813	88	0.029
sodium ion transport	GO:0006814	73	0.029
cognition	GO:0050890	149	0.029
regulation of multi organism process	GO:0043900	111	0.029
bone development	GO:0060348	120	0.029
response to nutrient levels	GO:0031667	109	0.029
interleukin 1 production	GO:0032612	31	0.029
synaptic transmission cholinergic	GO:0007271	7	0.029	Worm
learning	GO:0007612	98	0.028
connective tissue development	GO:0061448	179	0.028
mitotic cytokinesis	GO:0000281	4	0.028
visual behavior	GO:0007632	45	0.028
positive regulation of schwann cell proliferation	GO:0010625	1	0.028
heterocycle catabolic process	GO:0046700	280	0.028
regulation of circadian rhythm	GO:0042752	58	0.028
vasoconstriction	GO:0042310	27	0.028
cellular metal ion homeostasis	GO:0006875	151	0.028
neuron apoptotic process	GO:0051402	142	0.028
small gtpase mediated signal transduction	GO:0007264	97	0.028
regulation of protein complex assembly	GO:0043254	83	0.028
positive regulation of protein modification process	GO:0031401	299	0.028
positive regulation of calcium ion transport	GO:0051928	27	0.027
neuron projection guidance	GO:0097485	141	0.027
establishment of synaptic vesicle localization	GO:0097480	57	0.027
response to inorganic substance	GO:0010035	96	0.027
positive regulation of blood circulation	GO:1903524	22	0.027
regulation of membrane depolarization	GO:0003254	11	0.027
regulation of fat cell differentiation	GO:0045598	81	0.027
visual learning	GO:0008542	44	0.027
response to metal ion	GO:0010038	47	0.027
relaxation of cardiac muscle	GO:0055119	9	0.027
regulation of purine nucleotide catabolic process	GO:0033121	122	0.027
positive regulation of calcium ion transmembrane transporter activity	GO:1901021	8	0.027
regulation of gamma aminobutyric acid secretion	GO:0014052	2	0.027
neural crest cell migration involved in sympathetic nervous system development	GO:1903045	1	0.026
developmental maturation	GO:0021700	193	0.026
cell growth	GO:0016049	130	0.026
determination of left right symmetry	GO:0007368	80	0.026
positive regulation of synaptic transmission dopaminergic	GO:0032226	5	0.026
positive regulation of hormone secretion	GO:0046887	38	0.026
regulation of intracellular protein transport	GO:0033157	82	0.026
glycolipid biosynthetic process	GO:0009247	13	0.026
carboxylic acid transport	GO:0046942	100	0.026
positive regulation of cell migration	GO:0030335	109	0.026
calcium ion homeostasis	GO:0055074	127	0.026
eye photoreceptor cell differentiation	GO:0001754	41	0.026
developmental growth involved in morphogenesis	GO:0060560	138	0.026
regulation of myotube differentiation	GO:0010830	62	0.026
cellular response to cytokine stimulus	GO:0071345	189	0.025
regulation of catecholamine uptake involved in synaptic transmission	GO:0051940	2	0.025
positive regulation of programmed cell death	GO:0043068	218	0.025
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.025
positive regulation of kinase activity	GO:0033674	155	0.025
schwann cell development	GO:0014044	22	0.025
leukocyte mediated immunity	GO:0002443	174	0.025
positive regulation of fatty acid oxidation	GO:0046321	4	0.025
regulation of cell size	GO:0008361	72	0.025
cardiac muscle cell action potential involved in contraction	GO:0086002	6	0.025
regulation of catecholamine metabolic process	GO:0042069	10	0.025
positive regulation of neurotransmitter transport	GO:0051590	9	0.025
membrane repolarization	GO:0086009	7	0.025
cartilage development	GO:0051216	140	0.025
cellular component assembly involved in morphogenesis	GO:0010927	139	0.025	Zebrafish
circadian behavior	GO:0048512	13	0.024
response to steroid hormone	GO:0048545	56	0.024
positive regulation of blood pressure	GO:0045777	21	0.024
positive regulation of fat cell differentiation	GO:0045600	32	0.024
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.024

Ache disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.063
disease of anatomical entity	DOID:7	0.063
musculoskeletal system disease	DOID:17	0.039
central nervous system disease	DOID:331	0.027

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