IMP: Integrative Multi-species Prediction

Mus musculus

34 known processes

Adam15

a disintegrin and metallopeptidase domain 15 (metargidin)

(Aliases: metargidin,MDC15)

Entrez: 11490
Ensembl: ENSMUSG00000028041
UniProtKB: O88839

Process Predictions
Disease Predictions

Adam15 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of membrane protein ectodomain proteolysis	GO:0051044	3	0.891	Mouse
prevention of polyspermy	GO:0060468	4	0.880	Mouse
fibronectin dependent thymocyte migration	GO:0072681	1	0.845	Mouse
extracellular matrix dependent thymocyte migration	GO:0072680	1	0.771	Mouse
thymocyte migration	GO:0072679	2	0.675	Mouse
regulation of tumor necrosis factor ligand superfamily member 11 production	GO:2000307	1	0.670	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.667
regulation of fibronectin dependent thymocyte migration	GO:2000413	1	0.615	Mouse
regulation of thymocyte migration	GO:2000410	2	0.609	Mouse
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.492	Mouse
positive regulation of eosinophil migration	GO:2000418	2	0.484	Mouse
regulation of membrane protein ectodomain proteolysis	GO:0051043	3	0.469	Mouse
regulation of cell motility	GO:2000145	236	0.427	Human Mouse
regulation of t cell activation	GO:0050863	170	0.415	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.410	Mouse
myeloid cell homeostasis	GO:0002262	114	0.353	Mouse
response to organic cyclic compound	GO:0014070	198	0.342	Mouse
positive regulation of protein kinase activity	GO:0045860	144	0.318	Mouse
locomotory behavior	GO:0007626	195	0.308	Mouse
lymphocyte differentiation	GO:0030098	242	0.303	Mouse
mapk cascade	GO:0000165	281	0.290	Mouse
cation transport	GO:0006812	399	0.286
learning or memory	GO:0007611	148	0.284	Mouse
t cell activation	GO:0042110	289	0.271	Mouse
germinal center formation	GO:0002467	16	0.263	Mouse
regulation of t cell differentiation	GO:0045580	83	0.260	Mouse
regulation of eosinophil migration	GO:2000416	2	0.259	Mouse
striated muscle tissue development	GO:0014706	293	0.254
eosinophil migration	GO:0072677	3	0.250	Mouse
t cell differentiation	GO:0030217	174	0.248	Mouse
positive regulation of kinase activity	GO:0033674	155	0.247	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.247
muscle tissue development	GO:0060537	308	0.243
angiogenesis	GO:0001525	201	0.234	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.233
membrane protein proteolysis	GO:0033619	10	0.223	Mouse
regulation of lymphocyte differentiation	GO:0045619	107	0.223	Mouse
transmembrane transport	GO:0055085	412	0.222
transmission of nerve impulse	GO:0019226	76	0.219	Mouse
glycoprotein biosynthetic process	GO:0009101	89	0.207
ion transmembrane transport	GO:0034220	361	0.207
b cell activation	GO:0042113	161	0.204	Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.203	Mouse
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.198	Mouse
positive regulation of homeostatic process	GO:0032846	64	0.189	Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.189	Mouse
cognition	GO:0050890	149	0.186	Mouse
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.185	Mouse
leukocyte migration	GO:0050900	124	0.182	Mouse
response to light stimulus	GO:0009416	135	0.180	Mouse
regulation of cell migration	GO:0030334	219	0.179	Human Mouse
myelination in peripheral nervous system	GO:0022011	19	0.178	Mouse
ribose phosphate metabolic process	GO:0019693	291	0.178
schwann cell development	GO:0014044	22	0.178	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.175	Mouse
positive regulation of protein modification process	GO:0031401	299	0.172	Mouse
protein localization to membrane	GO:0072657	108	0.172
pma inducible membrane protein ectodomain proteolysis	GO:0051088	1	0.170	Mouse
stem cell differentiation	GO:0048863	268	0.167
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.163	Mouse
regulation of protein catabolic process	GO:0042176	108	0.162	Mouse
regulation of leukocyte differentiation	GO:1902105	159	0.162	Mouse
cation transmembrane transport	GO:0098655	266	0.161
macromolecule glycosylation	GO:0043413	55	0.157
leukocyte differentiation	GO:0002521	342	0.154	Mouse
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.151	Mouse
inflammatory response	GO:0006954	244	0.151	Mouse
granulocyte migration	GO:0097530	43	0.148	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.147
positive regulation of bone resorption	GO:0045780	13	0.145	Mouse
purine containing compound metabolic process	GO:0072521	311	0.144
regulation of transferase activity	GO:0051338	263	0.142	Mouse
inorganic cation transmembrane transport	GO:0098662	207	0.142
cardiac muscle tissue development	GO:0048738	130	0.141
positive regulation of bone remodeling	GO:0046852	13	0.141	Mouse
anion transport	GO:0006820	177	0.140
response to growth factor	GO:0070848	198	0.137	Mouse
glycoprotein metabolic process	GO:0009100	116	0.137
positive regulation of t cell differentiation	GO:0045582	52	0.132	Mouse
protein kinase b signaling	GO:0043491	74	0.130	Mouse
regulation of cell activation	GO:0050865	289	0.129	Mouse
positive regulation of fibronectin dependent thymocyte migration	GO:2000415	1	0.129	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.128	Mouse
multicellular organismal signaling	GO:0035637	91	0.125	Mouse
establishment of vesicle localization	GO:0051650	81	0.124
anatomical structure homeostasis	GO:0060249	145	0.124	Mouse
spleen development	GO:0048536	39	0.121	Mouse
visual behavior	GO:0007632	45	0.121	Mouse
response to radiation	GO:0009314	165	0.120	Mouse
regulation of protein kinase activity	GO:0045859	232	0.120	Mouse
positive regulation of nf kappab transcription factor activity	GO:0051092	30	0.119	Mouse
divalent inorganic cation transport	GO:0072511	178	0.119
positive regulation of lymphocyte activation	GO:0051251	140	0.118	Mouse
calcium ion transport	GO:0006816	159	0.117
response to peptide	GO:1901652	136	0.117
t cell differentiation in thymus	GO:0033077	77	0.116	Mouse
positive regulation of t cell activation	GO:0050870	101	0.115	Mouse
regulation of kinase activity	GO:0043549	249	0.112	Mouse
divalent metal ion transport	GO:0070838	172	0.109
neuronal action potential	GO:0019228	54	0.108	Mouse
positive regulation of cell migration	GO:0030335	109	0.108	Mouse
regulation of multi organism process	GO:0043900	111	0.107	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	352	0.107
membrane organization	GO:0061024	245	0.105
cellular amine metabolic process	GO:0044106	44	0.102
regulation of ion transport	GO:0043269	215	0.101
chemotaxis	GO:0006935	247	0.101	Mouse
skeletal system morphogenesis	GO:0048705	203	0.100
neuron apoptotic process	GO:0051402	142	0.100	Mouse
positive regulation of inflammatory response	GO:0050729	47	0.099	Mouse
activation of mapk activity	GO:0000187	59	0.099	Mouse
positive regulation of cell motility	GO:2000147	116	0.098	Mouse
multicellular organismal homeostasis	GO:0048871	164	0.097	Mouse
myeloid cell apoptotic process	GO:0033028	22	0.096	Mouse
positive regulation of tissue remodeling	GO:0034105	19	0.095	Mouse
regulation of intracellular transport	GO:0032386	159	0.093
activation of innate immune response	GO:0002218	56	0.093	Mouse
positive regulation of cell death	GO:0010942	224	0.093	Mouse
regulation of myotube differentiation	GO:0010830	62	0.092
cellular chemical homeostasis	GO:0055082	215	0.092
establishment of protein localization to membrane	GO:0090150	54	0.091
small gtpase mediated signal transduction	GO:0007264	97	0.090
regulation of membrane potential	GO:0042391	192	0.090	Mouse
myelination	GO:0042552	74	0.089	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.087	Mouse
cell adhesion	GO:0007155	329	0.086	Human Mouse
nucleotide metabolic process	GO:0009117	332	0.086
binding of sperm to zona pellucida	GO:0007339	34	0.086	Mouse
inorganic ion transmembrane transport	GO:0098660	234	0.086
regulation of neuron apoptotic process	GO:0043523	122	0.084	Mouse
synaptic vesicle transport	GO:0048489	57	0.083
glial cell development	GO:0021782	54	0.083	Mouse
positive regulation of tumor necrosis factor ligand superfamily member 11 production	GO:2000309	1	0.083	Mouse
visual learning	GO:0008542	44	0.083	Mouse
cellular carbohydrate metabolic process	GO:0044262	119	0.083
immune response activating signal transduction	GO:0002757	116	0.082	Mouse
cell cell recognition	GO:0009988	44	0.081	Mouse
actin cytoskeleton organization	GO:0030036	220	0.081
organic anion transport	GO:0015711	137	0.080
sodium ion transport	GO:0006814	73	0.080
aromatic compound catabolic process	GO:0019439	286	0.079
organophosphate biosynthetic process	GO:0090407	122	0.079
activation of immune response	GO:0002253	138	0.078	Mouse
macromolecule catabolic process	GO:0009057	281	0.077	Mouse
carbohydrate biosynthetic process	GO:0016051	74	0.077
response to peptide hormone	GO:0043434	127	0.077
positive regulation of cell adhesion	GO:0045785	80	0.076	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.076
guanosine containing compound metabolic process	GO:1901068	144	0.076
carbohydrate metabolic process	GO:0005975	230	0.076
cellular metal ion homeostasis	GO:0006875	151	0.076
blood circulation	GO:0008015	195	0.075
single fertilization	GO:0007338	82	0.075	Mouse
cell junction organization	GO:0034330	77	0.074
action potential	GO:0001508	78	0.074	Mouse
regulation of response to wounding	GO:1903034	189	0.074	Mouse
positive regulation of leukocyte differentiation	GO:1902107	86	0.074	Mouse
positive regulation of cellular catabolic process	GO:0031331	148	0.074	Mouse
positive regulation of lymphocyte differentiation	GO:0045621	61	0.072	Mouse
bone development	GO:0060348	120	0.072
schwann cell differentiation	GO:0014037	26	0.071	Mouse
leukocyte chemotaxis	GO:0030595	69	0.071	Mouse
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.071	Mouse
cellular ion homeostasis	GO:0006873	165	0.070
regulation of ion transmembrane transporter activity	GO:0032412	54	0.070
mucopolysaccharide metabolic process	GO:1903510	25	0.070
regulation of protein serine threonine kinase activity	GO:0071900	157	0.070	Mouse
skeletal system development	GO:0001501	356	0.069
adult locomotory behavior	GO:0008344	91	0.068	Mouse
oxidation reduction process	GO:0055114	342	0.067
positive regulation of intracellular transport	GO:0032388	70	0.067
regulation of protein localization	GO:0032880	231	0.067
associative learning	GO:0008306	61	0.066	Mouse
regulation of mapk cascade	GO:0043408	248	0.066	Mouse
muscle contraction	GO:0006936	101	0.066
regulation of homeostatic process	GO:0032844	182	0.065	Mouse
negative regulation of protein metabolic process	GO:0051248	282	0.065
endomembrane system organization	GO:0010256	147	0.065
single organism cell adhesion	GO:0098602	156	0.063	Mouse
developmental maturation	GO:0021700	193	0.063
learning	GO:0007612	98	0.063	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.063	Mouse
leukocyte homeostasis	GO:0001776	79	0.063	Mouse
protein catabolic process	GO:0030163	221	0.063	Mouse
cellular response to insulin stimulus	GO:0032869	78	0.062
negative regulation of leukocyte differentiation	GO:1902106	51	0.062
myeloid cell differentiation	GO:0030099	233	0.061
axonogenesis	GO:0007409	274	0.061
mesenchymal cell development	GO:0014031	93	0.061
blood vessel morphogenesis	GO:0048514	285	0.060	Mouse
plasma membrane organization	GO:0007009	90	0.060
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.059	Mouse
glycosyl compound metabolic process	GO:1901657	246	0.059
cell chemotaxis	GO:0060326	81	0.059	Mouse
forebrain development	GO:0030900	302	0.059
organic acid transport	GO:0015849	101	0.059
regulation of secretion by cell	GO:1903530	249	0.059
leukocyte migration involved in inflammatory response	GO:0002523	7	0.058	Mouse
immune response regulating signaling pathway	GO:0002764	125	0.058	Mouse
regulation of ion transmembrane transport	GO:0034765	119	0.058
chondrocyte differentiation	GO:0002062	72	0.058
purine ribonucleotide metabolic process	GO:0009150	290	0.058
gland development	GO:0048732	330	0.057
limb development	GO:0060173	166	0.057
adaptive immune response	GO:0002250	155	0.057	Mouse
membrane protein ectodomain proteolysis	GO:0006509	7	0.056	Mouse
regulation of tissue remodeling	GO:0034103	38	0.056	Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.056	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.055	Mouse
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.055
response to lipopolysaccharide	GO:0032496	128	0.055
regulation of transmembrane transport	GO:0034762	128	0.054
protein glycosylation	GO:0006486	55	0.053
positive regulation of response to wounding	GO:1903036	66	0.053	Mouse
cell substrate adhesion	GO:0031589	130	0.052	Human
cytosolic calcium ion transport	GO:0060401	48	0.052
acute inflammatory response	GO:0002526	41	0.052	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.052
carboxylic acid transport	GO:0046942	100	0.052
lung development	GO:0030324	164	0.051
peptidyl amino acid modification	GO:0018193	336	0.051
positive regulation of nervous system development	GO:0051962	221	0.051
egg activation	GO:0007343	7	0.051	Mouse
negative regulation of neuron apoptotic process	GO:0043524	92	0.051	Mouse
response to drug	GO:0042493	75	0.051	Mouse
neuron death	GO:0070997	154	0.050	Mouse
regulation of bone remodeling	GO:0046850	28	0.050	Mouse
regulation of cytokine production	GO:0001817	266	0.050	Mouse
regulation of transporter activity	GO:0032409	57	0.049
innate immune response	GO:0045087	157	0.049	Human Mouse
axon ensheathment	GO:0008366	76	0.049	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.049
positive regulation of secretion	GO:0051047	130	0.048
single organismal cell cell adhesion	GO:0016337	131	0.048	Mouse
homeostasis of number of cells	GO:0048872	210	0.048	Mouse
innate immune response activating signal transduction	GO:0002758	50	0.047	Mouse
amine metabolic process	GO:0009308	45	0.047
leukocyte apoptotic process	GO:0071887	71	0.047	Mouse
positive regulation of proteolysis	GO:0045862	85	0.047	Mouse
positive regulation of secretion by cell	GO:1903532	114	0.046
male gamete generation	GO:0048232	285	0.046
synaptic transmission	GO:0007268	329	0.046
gtp catabolic process	GO:0006184	143	0.046
purine nucleotide metabolic process	GO:0006163	302	0.045
regulation of mast cell apoptotic process	GO:0033025	5	0.045	Mouse
calcium ion transmembrane transport	GO:0070588	85	0.045
acylglycerol metabolic process	GO:0006639	55	0.045
regulation of t cell differentiation in thymus	GO:0033081	24	0.045	Mouse
response to extracellular stimulus	GO:0009991	127	0.044
cardiocyte differentiation	GO:0035051	87	0.044
maintenance of location	GO:0051235	89	0.044
cellular extravasation	GO:0045123	17	0.044	Mouse
cellular ketone metabolic process	GO:0042180	84	0.044
renal system development	GO:0072001	225	0.044
regulation of map kinase activity	GO:0043405	120	0.043	Mouse
striated muscle contraction	GO:0006941	45	0.043
b cell differentiation	GO:0030183	78	0.043	Mouse
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.043	Mouse
ensheathment of neurons	GO:0007272	76	0.043	Mouse
negative regulation of cellular amine metabolic process	GO:0033239	1	0.043
cd4 positive alpha beta t cell activation	GO:0035710	45	0.043
positive regulation of transferase activity	GO:0051347	167	0.043	Mouse
sensory perception	GO:0007600	245	0.043
glycosylation	GO:0070085	62	0.042
positive regulation of protein kinase b signaling	GO:0051897	32	0.042	Mouse
circulatory system process	GO:0003013	197	0.042
peptide transport	GO:0015833	133	0.042
regulation of protein kinase b signaling	GO:0051896	56	0.042	Mouse
response to inorganic substance	GO:0010035	96	0.042
regulation of cytoskeleton organization	GO:0051493	122	0.041
lipid transport	GO:0006869	98	0.041
peptidyl serine modification	GO:0018209	83	0.041
sensory perception of chemical stimulus	GO:0007606	51	0.040
inner ear receptor cell development	GO:0060119	39	0.040
regulation of apoptotic signaling pathway	GO:2001233	197	0.040
positive regulation of protein catabolic process	GO:0045732	60	0.040	Mouse
urogenital system development	GO:0001655	261	0.040
male gonad development	GO:0008584	88	0.039
positive regulation of programmed cell death	GO:0043068	218	0.039	Mouse
peptidyl serine phosphorylation	GO:0018105	74	0.039
cellular lipid metabolic process	GO:0044255	323	0.039
nucleoside phosphate biosynthetic process	GO:1901293	79	0.038
limb morphogenesis	GO:0035108	149	0.038
bone morphogenesis	GO:0060349	78	0.038
regulation of feeding behavior	GO:0060259	3	0.038
tumor necrosis factor ligand superfamily member 11 production	GO:0072535	1	0.038	Mouse
nephron development	GO:0072006	109	0.037
organonitrogen compound biosynthetic process	GO:1901566	192	0.037
regulation of actin filament based process	GO:0032970	99	0.037
intracellular protein transport	GO:0006886	204	0.037
regulation of cellular response to stress	GO:0080135	159	0.037
cation homeostasis	GO:0055080	212	0.037
cell cell junction organization	GO:0045216	72	0.037
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.037
regulation of muscle system process	GO:0090257	80	0.036
regulation of cell projection organization	GO:0031344	206	0.036
cellular response to hormone stimulus	GO:0032870	150	0.036
camp metabolic process	GO:0046058	40	0.036
endocytosis	GO:0006897	168	0.036
regulation of proteolysis	GO:0030162	164	0.036	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.036
polysaccharide biosynthetic process	GO:0000271	20	0.036
response to transforming growth factor beta	GO:0071559	88	0.035	Mouse
carbohydrate derivative catabolic process	GO:1901136	231	0.035
neutral lipid metabolic process	GO:0006638	57	0.035
skeletal muscle organ development	GO:0060538	163	0.035
regulation of system process	GO:0044057	200	0.035
lipid localization	GO:0010876	126	0.035
glycerolipid metabolic process	GO:0046486	122	0.035
sensory perception of smell	GO:0007608	26	0.035
negative regulation of intracellular signal transduction	GO:1902532	167	0.034
regulation of ossification	GO:0030278	112	0.034
negative regulation of molecular function	GO:0044092	258	0.034	Human
regulation of leukocyte apoptotic process	GO:2000106	56	0.034	Mouse
ribonucleoside metabolic process	GO:0009119	245	0.033
bone resorption	GO:0045453	38	0.033	Mouse
establishment of synaptic vesicle localization	GO:0097480	57	0.033
negative regulation of phosphorus metabolic process	GO:0010563	184	0.032
regulation of secretion	GO:0051046	274	0.032
male sex differentiation	GO:0046661	109	0.032
nucleoside catabolic process	GO:0009164	206	0.032
cellular component assembly involved in morphogenesis	GO:0010927	139	0.032
circadian temperature homeostasis	GO:0060086	2	0.032
t cell apoptotic process	GO:0070231	39	0.032	Mouse
positive regulation of thymocyte apoptotic process	GO:0070245	5	0.032	Mouse
sperm egg recognition	GO:0035036	37	0.031	Mouse
aminoglycan metabolic process	GO:0006022	34	0.031
ear development	GO:0043583	200	0.031
cellular response to cytokine stimulus	GO:0071345	189	0.031
myotube differentiation	GO:0014902	105	0.031
purine nucleotide biosynthetic process	GO:0006164	65	0.031
regulation of defense response	GO:0031347	233	0.031	Mouse
regulation of organelle organization	GO:0033043	289	0.031
sphingolipid metabolic process	GO:0006665	45	0.031
filopodium assembly	GO:0046847	19	0.030
epithelial cell development	GO:0002064	159	0.030
nucleoside metabolic process	GO:0009116	246	0.030
neutrophil migration	GO:1990266	37	0.029
nitrogen compound transport	GO:0071705	271	0.029
protein localization to plasma membrane	GO:0072659	57	0.029
sulfur compound biosynthetic process	GO:0044272	37	0.029
ras protein signal transduction	GO:0007265	77	0.029
organophosphate catabolic process	GO:0046434	232	0.029
positive regulation of acute inflammatory response	GO:0002675	16	0.029	Mouse
positive regulation of defense response	GO:0031349	124	0.029	Mouse
stem cell maintenance	GO:0019827	130	0.028
regulation of vesicle mediated transport	GO:0060627	139	0.028
ribonucleotide catabolic process	GO:0009261	208	0.028
purine nucleoside metabolic process	GO:0042278	241	0.028
positive regulation of cell development	GO:0010720	237	0.028
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.028
carboxylic acid catabolic process	GO:0046395	51	0.028
regulation of intracellular protein transport	GO:0033157	82	0.028
glycosaminoglycan biosynthetic process	GO:0006024	15	0.027
monocarboxylic acid transport	GO:0015718	44	0.027
regulation of metal ion transport	GO:0010959	106	0.027
lymphocyte apoptotic process	GO:0070227	54	0.027	Mouse
regulation of lymphocyte apoptotic process	GO:0070228	41	0.027	Mouse
nucleotide biosynthetic process	GO:0009165	78	0.027
establishment of organelle localization	GO:0051656	122	0.027
female sex differentiation	GO:0046660	84	0.027
receptor mediated endocytosis	GO:0006898	51	0.027
sulfur compound metabolic process	GO:0006790	100	0.027
regulation of muscle tissue development	GO:1901861	97	0.027
endochondral bone morphogenesis	GO:0060350	50	0.027
regulation of neuron death	GO:1901214	134	0.027	Mouse
small molecule catabolic process	GO:0044282	71	0.027
sequestering of calcium ion	GO:0051208	18	0.027
cytokine mediated signaling pathway	GO:0019221	115	0.027
regulation of cell shape	GO:0008360	39	0.026
ossification	GO:0001503	216	0.026
heart process	GO:0003015	94	0.026
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.026
cell fate commitment	GO:0045165	210	0.026
positive regulation of calcium ion transport	GO:0051928	27	0.026
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.026	Mouse
regulation of bone resorption	GO:0045124	24	0.026	Mouse
cellular lipid catabolic process	GO:0044242	52	0.026
cellular homeostasis	GO:0019725	240	0.026
regulation of myeloid cell apoptotic process	GO:0033032	19	0.026	Mouse
negative regulation of cell development	GO:0010721	169	0.026
extracellular matrix organization	GO:0030198	147	0.026
muscle system process	GO:0003012	141	0.026
purine ribonucleotide catabolic process	GO:0009154	208	0.026
response to organonitrogen compound	GO:0010243	246	0.025
immune effector process	GO:0002252	321	0.025
negative regulation of carbohydrate metabolic process	GO:0045912	19	0.025
negative regulation of cell fate specification	GO:0009996	4	0.025
chondrocyte development	GO:0002063	24	0.025
positive regulation of glucose transport	GO:0010828	16	0.025
basement membrane organization	GO:0071711	8	0.025
respiratory tube development	GO:0030323	167	0.025
development of primary male sexual characteristics	GO:0046546	88	0.025
tissue homeostasis	GO:0001894	115	0.025	Mouse
positive regulation of cytokine production	GO:0001819	174	0.025	Mouse
organelle assembly	GO:0070925	177	0.025
camp biosynthetic process	GO:0006171	31	0.025
regulation of thymocyte apoptotic process	GO:0070243	14	0.025	Mouse
appendage morphogenesis	GO:0035107	149	0.025
mitochondrion organization	GO:0007005	134	0.025
regulation of acute inflammatory response	GO:0002673	27	0.025	Mouse
positive regulation of ion transport	GO:0043270	65	0.025
regulation of inflammatory response	GO:0050727	147	0.024	Mouse
cellular response to organonitrogen compound	GO:0071417	145	0.024
fertilization	GO:0009566	127	0.024	Mouse
regulation of skeletal muscle fiber development	GO:0048742	36	0.024
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.024
establishment of protein localization to organelle	GO:0072594	118	0.024
negative regulation of cellular component organization	GO:0051129	194	0.024
organic acid catabolic process	GO:0016054	51	0.024
regulation of calcium ion transport	GO:0051924	69	0.024
negative regulation of phosphate metabolic process	GO:0045936	184	0.024
purine ribonucleoside metabolic process	GO:0046128	241	0.024
vesicle localization	GO:0051648	86	0.023
development of primary female sexual characteristics	GO:0046545	73	0.023
organelle localization	GO:0051640	179	0.023
rhythmic process	GO:0048511	174	0.023
protein maturation	GO:0051604	176	0.023
development of primary sexual characteristics	GO:0045137	143	0.023
polysaccharide metabolic process	GO:0005976	39	0.023
synaptic vesicle localization	GO:0097479	59	0.023
purine containing compound biosynthetic process	GO:0072522	70	0.023
tissue remodeling	GO:0048771	102	0.023	Mouse
regulation of calcium ion transmembrane transport	GO:1903169	20	0.023
purine nucleoside catabolic process	GO:0006152	205	0.023
regulation of nucleocytoplasmic transport	GO:0046822	73	0.023
regulation of cell cycle	GO:0051726	281	0.022
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	31	0.022	Mouse
sequestering of metal ion	GO:0051238	19	0.022
skin development	GO:0043588	220	0.022
neuron projection extension	GO:1990138	64	0.022
energy derivation by oxidation of organic compounds	GO:0015980	77	0.022
monosaccharide metabolic process	GO:0005996	106	0.022
regulation of carbohydrate metabolic process	GO:0006109	75	0.022
positive regulation of cell activation	GO:0050867	158	0.022	Mouse
skeletal muscle fiber development	GO:0048741	58	0.022
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.022
positive regulation of thymocyte migration	GO:2000412	2	0.022	Mouse
cyclic nucleotide metabolic process	GO:0009187	59	0.022
germ cell development	GO:0007281	185	0.022
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	30	0.022
positive regulation of transforming growth factor beta receptor signaling pathway	GO:0030511	12	0.022	Mouse
positive regulation of lymphocyte apoptotic process	GO:0070230	13	0.021	Mouse
cartilage development	GO:0051216	140	0.021
regulation of alpha beta t cell activation	GO:0046634	53	0.021
response to nutrient levels	GO:0031667	109	0.021
response to molecule of bacterial origin	GO:0002237	143	0.021
lens development in camera type eye	GO:0002088	62	0.021
cellular response to peptide	GO:1901653	92	0.021
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.021	Mouse
positive regulation of growth	GO:0045927	104	0.021
appendage development	GO:0048736	166	0.021
epidermis development	GO:0008544	187	0.021
adult behavior	GO:0030534	135	0.021	Mouse
response to corticosteroid	GO:0031960	20	0.021	Mouse
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.021
cellular phosphate ion homeostasis	GO:0030643	2	0.021
regulation of cell substrate adhesion	GO:0010810	73	0.021	Human
negative regulation of neuron projection development	GO:0010977	50	0.021
epithelial cell migration	GO:0010631	63	0.021
alpha beta t cell differentiation	GO:0046632	69	0.020
rac protein signal transduction	GO:0016601	13	0.020
regulation of myeloid cell differentiation	GO:0045637	96	0.020
extracellular structure organization	GO:0043062	148	0.020
amide transport	GO:0042886	138	0.020
spermatid differentiation	GO:0048515	115	0.020
regulation of rho gtpase activity	GO:0032319	58	0.020
anion transmembrane transport	GO:0098656	71	0.020
monocarboxylic acid metabolic process	GO:0032787	191	0.020
negative regulation of cytokine production	GO:0001818	84	0.020
positive regulation of leukocyte apoptotic process	GO:2000108	21	0.020	Mouse
digestive system development	GO:0055123	200	0.020
nucleoside triphosphate metabolic process	GO:0009141	230	0.020
negative regulation of cell motility	GO:2000146	61	0.020	Human
granulocyte chemotaxis	GO:0071621	39	0.020
leukocyte activation involved in immune response	GO:0002366	126	0.020
regulation of osteoclast differentiation	GO:0045670	36	0.019
regulation of cell growth	GO:0001558	91	0.019	Human
mast cell apoptotic process	GO:0033024	5	0.019	Mouse
cell type specific apoptotic process	GO:0097285	268	0.019	Mouse
negative regulation of fertilization	GO:0060467	5	0.019	Mouse
mesenchymal cell differentiation	GO:0048762	107	0.019
camera type eye development	GO:0043010	266	0.019
fatty acid transmembrane transport	GO:1902001	1	0.019
gtp metabolic process	GO:0046039	144	0.019
lipid catabolic process	GO:0016042	69	0.019
satellite cell activation involved in skeletal muscle regeneration	GO:0014901	3	0.019

Adam15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.126
disease of anatomical entity	DOID:7	0.126
muscular disease	DOID:0080000	0.126
nervous system disease	DOID:863	0.086
disease of metabolism	DOID:0014667	0.029
cardiovascular system disease	DOID:1287	0.022
central nervous system disease	DOID:331	0.021
eye and adnexa disease	DOID:1492	0.019
retinal disease	DOID:5679	0.019
sensory system disease	DOID:0050155	0.019
retinal degeneration	DOID:8466	0.019
eye disease	DOID:5614	0.019

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