IMP: Integrative Multi-species Prediction

Mus musculus

143 known processes

Atp6ap1

ATPase, H+ transporting, lysosomal accessory protein 1

(Aliases: Atp6ip1,VATPS1,AC45,FLJ00383,mFLJ00383,16A,Atp6s1,C7-1,AW108110,XAP-3,AI316502,CF2)

Entrez: 54411
Ensembl: ENSMUSG00000019087
UniProtKB: Q3UWN7
UniProtKB: Q9R1Q9
UniProtKB: Q3TWN7

Process Predictions
Disease Predictions

Atp6ap1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
ion transmembrane transport	GO:0034220	361	0.358
transmembrane transport	GO:0055085	412	0.294
cation transport	GO:0006812	399	0.294
sphingolipid metabolic process	GO:0006665	45	0.269
regulation of angiotensin levels in blood	GO:0002002	4	0.225
inorganic cation transmembrane transport	GO:0098662	207	0.219
hydrogen ion transmembrane transport	GO:1902600	25	0.178
cation transmembrane transport	GO:0098655	266	0.154
inorganic ion transmembrane transport	GO:0098660	234	0.151
divalent inorganic cation transport	GO:0072511	178	0.120
organonitrogen compound catabolic process	GO:1901565	264	0.113
membrane lipid biosynthetic process	GO:0046467	32	0.108
sphingolipid biosynthetic process	GO:0030148	26	0.106
pigmentation	GO:0043473	71	0.098	Zebrafish
cellular lipid metabolic process	GO:0044255	323	0.097
ceramide metabolic process	GO:0006672	31	0.094
carbohydrate derivative catabolic process	GO:1901136	231	0.092
proton transport	GO:0015992	35	0.092
notochord cell development	GO:0060035	1	0.085
positive regulation of necrotic cell death	GO:0010940	1	0.084
ceramide biosynthetic process	GO:0046513	20	0.083
vacuole organization	GO:0007033	38	0.082
organelle assembly	GO:0070925	177	0.076
lipid biosynthetic process	GO:0008610	179	0.075
membrane lipid metabolic process	GO:0006643	53	0.074
intracellular protein transport	GO:0006886	204	0.061
endocytosis	GO:0006897	168	0.061	Worm
metal ion homeostasis	GO:0055065	189	0.057
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.057
nucleoside monophosphate metabolic process	GO:0009123	85	0.057
calcium ion transport	GO:0006816	159	0.056
apoptotic signaling pathway	GO:0097190	306	0.054
regulation of angiotensin metabolic process	GO:0060177	4	0.053
lysosome organization	GO:0007040	21	0.050
nucleotide metabolic process	GO:0009117	332	0.049
nucleoside phosphate metabolic process	GO:0006753	338	0.048
rna interference	GO:0016246	2	0.047
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.044
lateral line system development	GO:0048925	1	0.044
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.043
cellular amino acid metabolic process	GO:0006520	103	0.042
organophosphate catabolic process	GO:0046434	232	0.041
amine metabolic process	GO:0009308	45	0.040
cellular homeostasis	GO:0019725	240	0.040
divalent metal ion transport	GO:0070838	172	0.040
positive regulation of programmed cell death	GO:0043068	218	0.039
positive regulation of wnt signaling pathway	GO:0030177	45	0.039
regulation of mapk cascade	GO:0043408	248	0.039
peptide metabolic process	GO:0006518	46	0.039
regionalization	GO:0003002	337	0.038
regulation of transferase activity	GO:0051338	263	0.037
regulation of wnt signaling pathway	GO:0030111	123	0.037
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.036
heterocycle catabolic process	GO:0046700	280	0.036
calcium ion transmembrane transport	GO:0070588	85	0.036
aromatic compound catabolic process	GO:0019439	286	0.035
nucleoside monophosphate catabolic process	GO:0009125	59	0.035
purine nucleoside metabolic process	GO:0042278	241	0.034
phospholipid metabolic process	GO:0006644	87	0.033
cellular amine metabolic process	GO:0044106	44	0.033
macromolecule catabolic process	GO:0009057	281	0.033
cellular component assembly involved in morphogenesis	GO:0010927	139	0.033
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.033
camera type eye development	GO:0043010	266	0.033	Zebrafish
sensory perception	GO:0007600	245	0.031
calcium ion homeostasis	GO:0055074	127	0.031
positive regulation of cellular amine metabolic process	GO:0033240	5	0.031
hydrogen transport	GO:0006818	35	0.031
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.031
gland development	GO:0048732	330	0.030
regulation of cellular amino acid metabolic process	GO:0006521	5	0.030
wnt signaling pathway	GO:0016055	188	0.029
posttranscriptional regulation of gene expression	GO:0010608	155	0.029
locomotory behavior	GO:0007626	195	0.029
anion transport	GO:0006820	177	0.029
cellular amide metabolic process	GO:0043603	58	0.029
retina development in camera type eye	GO:0060041	119	0.029	Zebrafish
purine ribonucleoside catabolic process	GO:0046130	205	0.029
purine nucleoside catabolic process	GO:0006152	205	0.028
atp catabolic process	GO:0006200	55	0.028
nucleobase containing small molecule metabolic process	GO:0055086	352	0.028
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.028
negative regulation of protein metabolic process	GO:0051248	282	0.028
neuromuscular process controlling balance	GO:0050885	59	0.028
sensory system development	GO:0048880	3	0.027
neuronal action potential	GO:0019228	54	0.027
membrane organization	GO:0061024	245	0.027
regulation of ion transport	GO:0043269	215	0.026
purine nucleotide metabolic process	GO:0006163	302	0.026
gonad development	GO:0008406	141	0.026
glycolipid metabolic process	GO:0006664	25	0.026
protein catabolic process	GO:0030163	221	0.026
glycosyl compound catabolic process	GO:1901658	206	0.026
divalent inorganic cation homeostasis	GO:0072507	138	0.025
cellular ion homeostasis	GO:0006873	165	0.025
regulation of establishment of protein localization	GO:0070201	181	0.025
astrocyte cell migration	GO:0043615	3	0.025
cellular chemical homeostasis	GO:0055082	215	0.025
cation homeostasis	GO:0055080	212	0.025
ribonucleotide metabolic process	GO:0009259	291	0.025
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.024
positive regulation of protein modification process	GO:0031401	299	0.024
cellular ketone metabolic process	GO:0042180	84	0.024
cytoplasmic transport	GO:0016482	234	0.024
regulation of membrane potential	GO:0042391	192	0.024
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.023
mapk cascade	GO:0000165	281	0.023
negative regulation of molecular function	GO:0044092	258	0.023
skin development	GO:0043588	220	0.023
nucleoside triphosphate catabolic process	GO:0009143	205	0.023
circulatory system process	GO:0003013	197	0.023
maintenance of location	GO:0051235	89	0.022
alcohol metabolic process	GO:0006066	116	0.022
atp metabolic process	GO:0046034	75	0.022
kidney development	GO:0001822	213	0.022
cellular metal ion homeostasis	GO:0006875	151	0.022
female gamete generation	GO:0007292	74	0.022
retrograde transport endosome to golgi	GO:0042147	2	0.022
organic hydroxy compound metabolic process	GO:1901615	203	0.022
rho protein signal transduction	GO:0007266	32	0.022
multicellular organismal signaling	GO:0035637	91	0.022
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.022
fertilization	GO:0009566	127	0.021
developmental maturation	GO:0021700	193	0.021
ribonucleoside metabolic process	GO:0009119	245	0.021
oligosaccharide catabolic process	GO:0009313	2	0.021
purine containing compound metabolic process	GO:0072521	311	0.021
positive regulation of mapk cascade	GO:0043410	170	0.021
tissue remodeling	GO:0048771	102	0.021
ribonucleoside catabolic process	GO:0042454	206	0.021
negative regulation of cellular protein metabolic process	GO:0032269	247	0.021
anatomical structure homeostasis	GO:0060249	145	0.021
nucleoside metabolic process	GO:0009116	246	0.020
regulation of cellular amine metabolic process	GO:0033238	20	0.020
embryonic organ morphogenesis	GO:0048562	276	0.020
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.020
dephosphorylation	GO:0016311	129	0.020
transmission of nerve impulse	GO:0019226	76	0.020
protein processing	GO:0016485	163	0.020
heart morphogenesis	GO:0003007	178	0.020
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.020
lytic vacuole organization	GO:0080171	21	0.020
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.020
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.019
regulation of protein transport	GO:0051223	163	0.019
positive regulation of cell activation	GO:0050867	158	0.019
lipid localization	GO:0010876	126	0.019
intrahepatic bile duct development	GO:0035622	2	0.019
purine ribonucleotide catabolic process	GO:0009154	208	0.019
receptor mediated endocytosis	GO:0006898	51	0.019	Worm
single fertilization	GO:0007338	82	0.019
regulation of systemic arterial blood pressure	GO:0003073	61	0.019
purine containing compound catabolic process	GO:0072523	213	0.019
epidermis development	GO:0008544	187	0.019
regulation of organelle organization	GO:0033043	289	0.018
multicellular organism growth	GO:0035264	161	0.018
sensory perception of sound	GO:0007605	97	0.018
positive regulation of cell death	GO:0010942	224	0.018
regulation of protein localization	GO:0032880	231	0.018
regulation of ion transmembrane transport	GO:0034765	119	0.018
regulation of neuron projection development	GO:0010975	169	0.018
response to inorganic substance	GO:0010035	96	0.018
development of primary sexual characteristics	GO:0045137	143	0.018
response to copper ion	GO:0046688	3	0.018
glycosphingolipid catabolic process	GO:0046479	5	0.018
wound healing	GO:0042060	157	0.018
regulation of protein kinase activity	GO:0045859	232	0.018
circadian sleep wake cycle rem sleep	GO:0042747	1	0.018
retina morphogenesis in camera type eye	GO:0060042	45	0.018
regulation of lymphocyte activation	GO:0051249	240	0.018
regulation of hormone levels	GO:0010817	211	0.018
early endosome to late endosome transport	GO:0045022	2	0.018
regulation of transmembrane transport	GO:0034762	128	0.018
organic hydroxy compound transport	GO:0015850	93	0.017
action potential	GO:0001508	78	0.017
glycerophospholipid metabolic process	GO:0006650	71	0.017
cellular nitrogen compound catabolic process	GO:0044270	280	0.017
necrotic cell death	GO:0070265	30	0.017
aminoglycan metabolic process	GO:0006022	34	0.017
organonitrogen compound biosynthetic process	GO:1901566	192	0.017
nucleoside triphosphate metabolic process	GO:0009141	230	0.017
regulation of cell projection organization	GO:0031344	206	0.017
reactive oxygen species metabolic process	GO:0072593	84	0.017
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.017
ribose phosphate metabolic process	GO:0019693	291	0.017
gene silencing by rna	GO:0031047	19	0.017
muscle system process	GO:0003012	141	0.017
regulation of cellular ketone metabolic process	GO:0010565	66	0.017
ketone catabolic process	GO:0042182	3	0.017
cellular calcium ion homeostasis	GO:0006874	119	0.016
regulation of cell cycle	GO:0051726	281	0.016
endomembrane system organization	GO:0010256	147	0.016
snare complex disassembly	GO:0035494	2	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.016
ensheathment of neurons	GO:0007272	76	0.016
positive regulation of growth	GO:0045927	104	0.016
sphingosine metabolic process	GO:0006670	4	0.016
hormone metabolic process	GO:0042445	86	0.016
carboxylic acid biosynthetic process	GO:0046394	86	0.016
establishment of protein localization to membrane	GO:0090150	54	0.016
male courtship behavior	GO:0008049	2	0.016
negative regulation of nervous system development	GO:0051961	156	0.016
regulation of cellular response to stress	GO:0080135	159	0.015
establishment of vesicle localization	GO:0051650	81	0.015
protein localization to organelle	GO:0033365	185	0.015
potassium ion transport	GO:0006813	52	0.015
embryonic retina morphogenesis in camera type eye	GO:0060059	7	0.015
liposaccharide metabolic process	GO:1903509	27	0.015
exocytosis	GO:0006887	121	0.015
small molecule biosynthetic process	GO:0044283	132	0.015
cell adhesion	GO:0007155	329	0.015
sterol transport	GO:0015918	38	0.015
regulation of secretion	GO:0051046	274	0.015
organelle localization	GO:0051640	179	0.015
regulation of calcium ion transport	GO:0051924	69	0.015
hematopoietic progenitor cell differentiation	GO:0002244	143	0.014
glycosaminoglycan metabolic process	GO:0030203	34	0.014
positive regulation of fibroblast growth factor receptor signaling pathway	GO:0045743	3	0.014
nucleotide catabolic process	GO:0009166	217	0.014
immune effector process	GO:0002252	321	0.014
response to oxidative stress	GO:0006979	123	0.014
cellular response to oxidative stress	GO:0034599	76	0.014
sensory organ morphogenesis	GO:0090596	242	0.014
negative regulation of intracellular signal transduction	GO:1902532	167	0.014
ceramide catabolic process	GO:0046514	7	0.014
signal transduction in absence of ligand	GO:0038034	55	0.014
purine ribonucleotide metabolic process	GO:0009150	290	0.014
regulation of neuron differentiation	GO:0045664	281	0.014
regulation of neuron apoptotic process	GO:0043523	122	0.014
negative regulation of cell development	GO:0010721	169	0.014
inter male aggressive behavior	GO:0002121	3	0.014
transition metal ion transport	GO:0000041	38	0.014
organic acid biosynthetic process	GO:0016053	86	0.014
learning or memory	GO:0007611	148	0.014
response to fibroblast growth factor	GO:0071774	47	0.014
striated muscle tissue development	GO:0014706	293	0.014
blood circulation	GO:0008015	195	0.014
regulation of apoptotic signaling pathway	GO:2001233	197	0.013
cell growth	GO:0016049	130	0.013
regulation of blood pressure	GO:0008217	93	0.013
molting cycle	GO:0042303	90	0.013	Worm
purine nucleotide catabolic process	GO:0006195	211	0.013
negative regulation of neuron death	GO:1901215	98	0.013
regulation of syncytium formation by plasma membrane fusion	GO:0060142	23	0.013
regulation of cell growth	GO:0001558	91	0.013
negative regulation of protein modification process	GO:0031400	163	0.013
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.013
stem cell differentiation	GO:0048863	268	0.013
germ cell development	GO:0007281	185	0.013
cellular macromolecule catabolic process	GO:0044265	206	0.013
leukocyte mediated immunity	GO:0002443	174	0.013
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.013
protein localization to plasma membrane	GO:0072659	57	0.013
positive regulation of apoptotic process	GO:0043065	217	0.013
phospholipid biosynthetic process	GO:0008654	36	0.013
ribonucleotide catabolic process	GO:0009261	208	0.013
organic anion transport	GO:0015711	137	0.013
neuromuscular process	GO:0050905	99	0.013
adult walking behavior	GO:0007628	41	0.013
purine ribonucleoside metabolic process	GO:0046128	241	0.013
eye pigmentation	GO:0048069	3	0.013
nuclear transport	GO:0051169	139	0.012
progesterone metabolic process	GO:0042448	4	0.012
establishment of protein localization to plasma membrane	GO:0090002	34	0.012
male gamete generation	GO:0048232	285	0.012
response to reactive oxygen species	GO:0000302	56	0.012
protein localization to endosome	GO:0036010	2	0.012
renal system development	GO:0072001	225	0.012
interspecies interaction between organisms	GO:0044419	83	0.012
regulation of cellular component biogenesis	GO:0044087	181	0.012
axonogenesis	GO:0007409	274	0.012
protein localization to membrane	GO:0072657	108	0.012
adult locomotory behavior	GO:0008344	91	0.012
sphingolipid catabolic process	GO:0030149	7	0.012
regulation of intracellular transport	GO:0032386	159	0.012
negative regulation of hormone biosynthetic process	GO:0032353	4	0.012
intrinsic apoptotic signaling pathway	GO:0097193	132	0.012
embryonic heart tube morphogenesis	GO:0003143	51	0.012
natural killer cell activation involved in immune response	GO:0002323	10	0.012
protein localization to vacuole	GO:0072665	4	0.012
regulation of body fluid levels	GO:0050878	162	0.012
regulation of circadian sleep wake cycle	GO:0042749	3	0.012
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.012
regulation of lipid metabolic process	GO:0019216	118	0.012
l ascorbic acid metabolic process	GO:0019852	4	0.012
cellular response to thyroid hormone stimulus	GO:0097067	1	0.012
granzyme mediated apoptotic signaling pathway	GO:0008626	1	0.012
response to radiation	GO:0009314	165	0.012
plasma membrane organization	GO:0007009	90	0.011
non canonical wnt signaling pathway	GO:0035567	33	0.011
extracellular structure organization	GO:0043062	148	0.011
steroid metabolic process	GO:0008202	119	0.011
regulation of removal of superoxide radicals	GO:2000121	4	0.011
amino acid transport	GO:0006865	61	0.011
glycerolipid metabolic process	GO:0046486	122	0.011
protein targeting	GO:0006605	143	0.011
regulation of secretion by cell	GO:1903530	249	0.011
gene silencing	GO:0016458	38	0.011
axon ensheathment	GO:0008366	76	0.011
central nervous system neuron differentiation	GO:0021953	162	0.011
engulfment of apoptotic cell	GO:0043652	3	0.011
lymphocyte differentiation	GO:0030098	242	0.011
regulation of monocyte chemotaxis	GO:0090025	3	0.011
response to endoplasmic reticulum stress	GO:0034976	53	0.011
lipoprotein biosynthetic process	GO:0042158	33	0.011
regulation of kinase activity	GO:0043549	249	0.011
ear development	GO:0043583	200	0.011
regulation of multi organism process	GO:0043900	111	0.011
regulation of intracellular protein transport	GO:0033157	82	0.011
macroautophagy	GO:0016236	21	0.011
negative regulation of multi organism process	GO:0043901	68	0.011
regulation of cell activation	GO:0050865	289	0.011
sequestering of metal ion	GO:0051238	19	0.011
negative regulation of protein transport	GO:0051224	46	0.011
muscle contraction	GO:0006936	101	0.011
organophosphate biosynthetic process	GO:0090407	122	0.011
cholesterol metabolic process	GO:0008203	56	0.011
regulation of beta amyloid clearance	GO:1900221	1	0.011
organic cyclic compound catabolic process	GO:1901361	295	0.011
regulation of proteolysis	GO:0030162	164	0.011
t cell activation	GO:0042110	289	0.011
c21 steroid hormone biosynthetic process	GO:0006700	3	0.011
carbohydrate metabolic process	GO:0005975	230	0.011
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.011
regulation of androgen receptor signaling pathway	GO:0060765	3	0.011
response to organic cyclic compound	GO:0014070	198	0.011
meiotic cell cycle	GO:0051321	122	0.011
nucleoside catabolic process	GO:0009164	206	0.011
positive regulation of lymphocyte activation	GO:0051251	140	0.011
water soluble vitamin biosynthetic process	GO:0042364	3	0.011
posttranscriptional gene silencing by rna	GO:0035194	10	0.011
regulation of purine nucleotide metabolic process	GO:1900542	169	0.010
peptidyl amino acid modification	GO:0018193	336	0.010
trivalent inorganic cation transport	GO:0072512	5	0.010
microglia differentiation	GO:0014004	2	0.010
nitrogen compound transport	GO:0071705	271	0.010
cellular sodium ion homeostasis	GO:0006883	1	0.010
ras protein signal transduction	GO:0007265	77	0.010
endodermal cell fate specification	GO:0001714	4	0.010
single organism nuclear import	GO:1902593	95	0.010
protein ubiquitination	GO:0016567	171	0.010
localization within membrane	GO:0051668	4	0.010
detection of abiotic stimulus	GO:0009582	60	0.010
multicellular organismal homeostasis	GO:0048871	164	0.010
regulation of mitotic cell cycle	GO:0007346	126	0.010
cellular modified amino acid biosynthetic process	GO:0042398	12	0.010
central nervous system morphogenesis	GO:0021551	2	0.010
carbohydrate catabolic process	GO:0016052	32	0.010
negative regulation of growth	GO:0045926	99	0.010
detection of stimulus	GO:0051606	84	0.010
developmental growth involved in morphogenesis	GO:0060560	138	0.010
spermatogenesis	GO:0007283	284	0.010
positive regulation of protein phosphorylation	GO:0001934	242	0.010
lipid transport	GO:0006869	98	0.010
negative regulation of cellular component organization	GO:0051129	194	0.010

Atp6ap1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
inherited metabolic disorder	DOID:655	0.480
lysosomal storage disease	DOID:3211	0.480
disease of metabolism	DOID:0014667	0.480
lipid storage disease	DOID:9455	0.480
sphingolipidosis	DOID:1927	0.222
central nervous system disease	DOID:331	0.103
nervous system disease	DOID:863	0.103
disease of anatomical entity	DOID:7	0.103
brain disease	DOID:936	0.086
immune system disease	DOID:2914	0.045
cerebral degeneration	DOID:1443	0.029
acquired metabolic disease	DOID:0060158	0.028
intellectual disability	DOID:1059	0.020
disease of mental health	DOID:150	0.020
developmental disorder of mental health	DOID:0060037	0.020
non syndromic intellectual disability	DOID:0050889	0.020
specific developmental disorder	DOID:0060038	0.020
eye disease	DOID:5614	0.020
eye and adnexa disease	DOID:1492	0.020
sensory system disease	DOID:0050155	0.020
retinal disease	DOID:5679	0.020
musculoskeletal system disease	DOID:17	0.017
neurodegenerative disease	DOID:1289	0.015
connective tissue disease	DOID:65	0.015
lymphatic system disease	DOID:75	0.012
bone disease	DOID:0080001	0.011
retinal degeneration	DOID:8466	0.011
hematopoietic system disease	DOID:74	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network