Mus musculus

78 known processes

Casp4

caspase 4, apoptosis-related cysteine peptidase

(Aliases: Casp11,Caspl,ich-3)

Casp4 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of necroptotic processGO:006054691.000
Mouse
defense response to other organismGO:00985421971.000
cellular response to molecule of bacterial originGO:0071219831.000
cellular response to lipopolysaccharideGO:0071222771.000
cellular response to biotic stimulusGO:0071216921.000
regulation of defense response to bacteriumGO:190042431.000
activation of innate immune responseGO:0002218561.000
positive regulation of cytokine productionGO:00018191741.000
positive regulation of defense responseGO:00313491240.999
regulation of defense responseGO:00313472330.999
Mouse
cellular response to interferon betaGO:0035458210.999
response to molecule of bacterial originGO:00022371430.999
Mouse
i kappab kinase nf kappab signalingGO:0007249850.999
Mouse
inflammatory responseGO:00069542440.999
Mouse
antibacterial peptide productionGO:000277820.999
antibacterial peptide biosynthetic processGO:000278020.999
cellular response to cytokine stimulusGO:00713451890.999
positive regulation of innate immune responseGO:0045089800.999
necroptotic processGO:0070266210.999
Mouse
response to lipopolysaccharideGO:00324961280.998
Mouse
response to atpGO:003319880.998
Mouse
positive regulation of peptidase activityGO:0010952490.998
Mouse Fly
positive regulation of interleukin 8 productionGO:003275720.998
regulation of necroptotic processGO:0060544100.998
Mouse
antibacterial humoral responseGO:001973180.998
positive regulation of antimicrobial peptide productionGO:000222510.998
regulation of sequence specific dna binding transcription factor activityGO:00510901060.997
negative regulation of cytokine productionGO:0001818840.997
defense response to virusGO:0051607680.997
regulation of cytokine productionGO:00018172660.997
positive regulation of interleukin 1 secretionGO:0050716140.997
regulation of defense response to virusGO:0050688180.997
regulation of innate immune responseGO:0045088910.997
regulation of response to biotic stimulusGO:0002831380.997
symbiosis encompassing mutualism through parasitismGO:0044403830.997
regulation of protein import into nucleusGO:0042306520.997
cytokine productionGO:00018163190.996
regulation of necrotic cell deathGO:0010939130.996
Mouse
regulation of protein transportGO:00512231630.996
regulation of interleukin 1 productionGO:0032652260.995
defense response to gram positive bacteriumGO:0050830500.995
regulation of protein targetingGO:1903533610.995
interspecies interaction between organismsGO:0044419830.995
antimicrobial peptide productionGO:000277520.995
positive regulation of cysteine type endopeptidase activityGO:2001056390.995
Mouse Fly
positive regulation of interleukin 1 beta productionGO:0032731160.994
regulation of antibacterial peptide productionGO:000278610.994
regulation of defense response to virus by hostGO:005069180.994
positive regulation of cytokine secretionGO:0050715410.993
interleukin 1 beta productionGO:0032611300.993
regulation of establishment of protein localizationGO:00702011810.993
positive regulation of antibacterial peptide biosynthetic processGO:000696310.992
defense response to bacteriumGO:00427421190.991
cytoplasmic pattern recognition receptor signaling pathwayGO:0002753100.991
interleukin 1 productionGO:0032612310.991
regulation of inflammatory responseGO:00507271470.989
Mouse
positive regulation of antimicrobial peptide biosynthetic processGO:000280710.988
regulation of multi organism processGO:00439001110.988
immune effector processGO:00022523210.988
pyroptosisGO:007026980.987
chemokine productionGO:0032602340.986
activation of immune responseGO:00022531380.986
regulation of circadian sleep wake cycle non rem sleepGO:004518810.985
regulation of interferon gamma productionGO:0032649570.985
antimicrobial peptide biosynthetic processGO:000277720.984
interleukin 8 productionGO:003263740.983
regulation of lymphocyte proliferationGO:00506701170.983
Mouse
regulation of antibacterial peptide biosynthetic processGO:000280810.982
innate immune responseGO:00450871570.982
Fly
adaptive immune responseGO:00022501550.982
positive regulation of defense response to bacteriumGO:190042610.981
positive regulation of interleukin 1 alpha productionGO:003273040.981
Mouse
regulation of antimicrobial humoral responseGO:000275930.979
regulation of antimicrobial peptide productionGO:000278410.978
immune response regulating signaling pathwayGO:00027641250.977
regulation of interleukin 6 productionGO:0032675550.977
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.976
Mouse Fly
positive regulation of secretion by cellGO:19035321140.975
t cell proliferationGO:00420981200.974
Mouse
interleukin 1 beta secretionGO:0050702160.973
regulation of apoptotic dna fragmentationGO:190251050.972
Mouse
interleukin 1 secretionGO:0050701160.972
positive regulation of interleukin 1 beta secretionGO:0050718140.972
regulation of circadian sleep wake cycleGO:004274930.972
interleukin 1 alpha secretionGO:005070330.971
Mouse
regulation of protein localizationGO:00328802310.970
dna catabolic process endonucleolyticGO:0000737150.969
Mouse
positive regulation of antimicrobial humoral responseGO:000276020.969
regulation of protein localization to nucleusGO:1900180600.969
establishment of protein localization to organelleGO:00725941180.968
protein localization to organelleGO:00333651850.968
regulation of circadian sleep wake cycle sleepGO:004518730.967
intrinsic apoptotic signaling pathway in response to oxidative stressGO:0008631190.966
Mouse
nuclear importGO:0051170950.966
positive regulation of interleukin 1 alpha secretionGO:005071730.965
Mouse
inflammatory response to woundingGO:009059440.965
nucleotide binding oligomerization domain containing signaling pathwayGO:007042360.965
regulation of endopeptidase activityGO:0052548890.965
Mouse Fly
apoptotic mitochondrial changesGO:0008637480.965
Mouse
pattern recognition receptor signaling pathwayGO:0002221470.964
positive regulation of protein secretionGO:0050714520.964
protein secretionGO:00093061110.964
regulation of intracellular protein transportGO:0033157820.964
regulation of proteolysisGO:00301621640.963
Mouse Fly
cellular response to glucocorticoid stimulusGO:0071385130.962
Mouse
defense response to protozoanGO:0042832250.959
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126740.959
Fly
positive regulation of proteolysisGO:0045862850.958
Mouse Fly
response to endoplasmic reticulum stressGO:0034976530.957
Mouse
positive regulation of programmed cell deathGO:00430682180.956
Mouse Fly
lipopolysaccharide mediated signaling pathwayGO:0031663250.956
single organism nuclear importGO:1902593950.954
regulation of response to woundingGO:19030341890.953
Mouse
leukocyte activation involved in immune responseGO:00023661260.950
positive regulation of apoptotic processGO:00430652170.950
Mouse Fly
production of molecular mediator of immune responseGO:00024401030.949
membrane hyperpolarizationGO:0060081210.943
Mouse
regulation of nucleocytoplasmic transportGO:0046822730.942
positive regulation of protein transportGO:0051222930.940
negative regulation of phosphorus metabolic processGO:00105631840.940
Mouse
regulation of execution phase of apoptosisGO:190011790.937
Mouse
regulation of leukocyte proliferationGO:00706631210.934
Mouse
regulation of t cell activationGO:00508631700.933
Mouse
t cell activationGO:00421102890.931
Mouse
positive regulation of interleukin 1 productionGO:0032732170.931
regulation of reactive oxygen species metabolic processGO:2000377400.929
wound healing involved in inflammatory responseGO:000224640.925
regulation of stress activated mapk cascadeGO:0032872690.923
defense response to gram negative bacteriumGO:0050829280.920
protein localization to nucleusGO:00345041210.920
regulation of antimicrobial peptide biosynthetic processGO:000280510.919
regulation of peptidase activityGO:0052547960.919
Mouse Fly
zymogen activationGO:0031638410.917
Mouse Fly
regulation of type i interferon productionGO:0032479220.916
regulation of lymphocyte apoptotic processGO:0070228410.915
Mouse
jnk cascadeGO:0007254720.915
regulation of cell activationGO:00508652890.911
Mouse
regulation of chemokine productionGO:0032642300.906
positive regulation of endopeptidase activityGO:0010950430.905
Mouse Fly
regulation of adaptive immune responseGO:0002819900.905
nucleocytoplasmic transportGO:00069131390.903
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126930.900
Fly
cell activation involved in immune responseGO:00022631260.899
regulation of t cell proliferationGO:0042129920.896
Mouse
regulation of cytokine secretionGO:0050707610.896
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.895
Mouse
regulation of apoptotic signaling pathwayGO:20012331970.895
Mouse Fly
membrane depolarizationGO:0051899640.895
Mouse
toll like receptor signaling pathwayGO:0002224380.893
regulation of cysteine type endopeptidase activityGO:2000116650.892
Mouse Fly
negative regulation of cyclin dependent protein serine threonine kinase activityGO:004573690.891
Mouse
positive regulation of defense response to virus by hostGO:000223060.891
circadian behaviorGO:0048512130.891
positive regulation of secretionGO:00510471300.884
interleukin 6 productionGO:0032635580.882
regulation of interferon alpha productionGO:003264750.881
type i interferon productionGO:0032606290.880
regulation of interleukin 1 secretionGO:0050704150.878
tumor necrosis factor productionGO:0032640500.878
regulation of leukocyte apoptotic processGO:2000106560.877
Mouse
regulation of jnk cascadeGO:0046328620.876
intrinsic apoptotic signaling pathwayGO:00971931320.872
Mouse
regulation of hydrolase activityGO:00513362460.871
Mouse Fly
intracellular protein transportGO:00068862040.868
activation of cysteine type endopeptidase activityGO:0097202270.867
Mouse Fly
cytoplasmic transportGO:00164822340.866
apoptotic dna fragmentationGO:000630970.865
Mouse
positive regulation of immune effector processGO:00026991070.864
glial cell apoptotic processGO:003434930.863
Mouse
negative regulation of cellular protein metabolic processGO:00322692470.863
Mouse
connective tissue replacement involved in inflammatory response wound healingGO:000224830.861
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.860
immune response activating signal transductionGO:00027571160.858
peptide biosynthetic processGO:0043043110.857
extrinsic apoptotic signaling pathwayGO:00971911260.856
Mouse
sperm individualizationGO:000729110.856
Fly
lymphocyte proliferationGO:00466511640.855
Mouse
negative regulation of protein metabolic processGO:00512482820.854
Mouse
positive regulation of interleukin 6 productionGO:0032755370.849
cellular response to interferon gammaGO:0071346250.849
cellular amide metabolic processGO:0043603580.843
positive regulation of interferon gamma productionGO:0032729390.843
phagocytosisGO:0006909660.843
Worm
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.843
Mouse
cellular component disassembly involved in execution phase of apoptosisGO:000692190.841
Mouse
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079160.840
Mouse
regulation of interleukin 1 alpha productionGO:003265040.839
Mouse
positive regulation of chemokine productionGO:0032722220.837
interferon beta biosynthetic processGO:004535040.836
positive regulation of production of molecular mediator of immune responseGO:0002702450.835
keratinocyte differentiationGO:0030216480.834
Mouse
regulation of defense response to fungusGO:190015010.833
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919270.833
Mouse Fly
protein import into nucleusGO:0006606950.832
protein targetingGO:00066051430.831
negative regulation of immune system processGO:00026832090.830
Mouse
cellular response to dna damage stimulusGO:00069742070.829
Mouse
cellular response to lipidGO:00713961450.829
Mouse
positive regulation of cell deathGO:00109422240.828
Mouse Fly
homeostasis of number of cellsGO:00488722100.826
Mouse
compound eye developmentGO:004874910.825
Fly
stress activated protein kinase signaling cascadeGO:0031098810.824
positive regulation of adaptive immune responseGO:0002821610.824
b cell mediated immunityGO:0019724710.824
positive regulation of hydrolase activityGO:00513451480.822
Mouse Fly
protein ubiquitinationGO:00165671710.822
regulation of intracellular transportGO:00323861590.819
regulation of interleukin 10 secretionGO:200117940.819
leukocyte proliferationGO:00706611720.815
Mouse
immunoglobulin mediated immune responseGO:0016064690.807
positive regulation of response to biotic stimulusGO:0002833150.805
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.804
positive regulation of interleukin 6 secretionGO:200077810.803
regulation of secretionGO:00510462740.797
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.793
Mouse Fly
regulation of lymphocyte activationGO:00512492400.792
Mouse
apoptotic signaling pathwayGO:00971903060.787
Mouse Fly
cellular response to organic cyclic compoundGO:0071407870.787
Mouse
cellular response to peptidoglycanGO:007122440.785
innate immune response activating signal transductionGO:0002758500.784
cytokine secretionGO:0050663720.780
mitochondrion organizationGO:00070051340.779
Mouse
autophagyGO:0006914450.777
Mouse Fly
regulation of acute inflammatory responseGO:0002673270.774
positive regulation of neutrophil mediated killing of symbiont cellGO:007096110.772
response to interleukin 1GO:0070555110.772
positive regulation of chemokine secretionGO:009019740.771
cellularizationGO:000734910.771
Fly
leukocyte differentiationGO:00025213420.770
Mouse
detection of molecule of bacterial originGO:003249020.769
peptide transportGO:00158331330.767
thymocyte apoptotic processGO:0070242190.766
Mouse
positive regulation of jnk cascadeGO:0046330460.765
regulation of tumor necrosis factor productionGO:0032680490.764
negative regulation of protein transportGO:0051224460.753
lymphocyte apoptotic processGO:0070227540.752
Mouse
positive regulation of interleukin 8 secretionGO:200048410.751
negative regulation of phosphate metabolic processGO:00459361840.751
Mouse
regulation of production of molecular mediator of immune responseGO:0002700650.748
stress activated mapk cascadeGO:0051403800.748
negative regulation of protein phosphorylationGO:00019331260.747
Mouse
negative regulation of leukocyte proliferationGO:0070664460.744
Mouse
negative regulation of phosphorylationGO:00423261660.744
Mouse
response to dexamethasoneGO:007154880.743
Mouse
mitochondrial depolarizationGO:005188260.739
Mouse
nucleotide binding oligomerization domain containing 2 signaling pathwayGO:007043160.736
regulation of thymocyte apoptotic processGO:0070243140.735
Mouse
protein maturationGO:00516041760.732
Mouse Worm Fly
negative regulation of activated t cell proliferationGO:004600770.731
Mouse
regulation of secretion by cellGO:19035302490.731
cellular response to corticosteroid stimulusGO:0071384130.726
Mouse
regulation of transcription factor import into nucleusGO:0042990240.724
b cell proliferationGO:0042100530.716
Mouse
negative regulation of t cell activationGO:0050868650.716
Mouse
regulation of interleukin 1 beta secretionGO:0050706150.708
positive regulation of lymphocyte activationGO:00512511400.705
regulation of interleukin 18 productionGO:003266130.704
neutrophil mediated killing of gram negative bacteriumGO:007094540.702
regulation of protein secretionGO:0050708820.702
regulation of protein serine threonine kinase activityGO:00719001570.701
Mouse
protein autoprocessingGO:001654020.700
Worm Fly
release of cytochrome c from mitochondriaGO:0001836230.699
Mouse
positive regulation of protein import into nucleusGO:0042307260.683
engulfment of apoptotic cellGO:004365230.682
Worm
cytokine mediated signaling pathwayGO:00192211150.676
syncytium formation by plasma membrane fusionGO:0000768420.672
positive regulation of organelle organizationGO:00106381280.671
lymphocyte activation involved in immune responseGO:0002285930.667
mapk cascadeGO:00001652810.666
protein importGO:00170381010.665
regulation of interleukin 1 beta productionGO:0032651250.664
response to organophosphorusGO:0046683220.663
Mouse
interferon beta productionGO:0032608160.661
response to interferon betaGO:0035456220.645
positive regulation of lymphocyte proliferationGO:0050671700.641
organonitrogen compound biosynthetic processGO:19015661920.641
leukocyte apoptotic processGO:0071887710.640
Mouse
regulation of neutrophil mediated killing of gram negative bacteriumGO:007095110.640
hepatocyte apoptotic processGO:0097284110.634
Mouse
t cell apoptotic processGO:0070231390.629
Mouse
pigment metabolic processGO:0042440320.628
Fly
b cell activationGO:00421131610.618
Mouse
regulation of b cell activationGO:0050864810.617
Mouse
negative regulation of lymphocyte proliferationGO:0050672450.612
Mouse
secondary metabolic processGO:0019748180.611
Fly
negative regulation of protein modification processGO:00314001630.607
Mouse
positive regulation of leukocyte proliferationGO:0070665730.604
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.603
positive regulation of stress activated mapk cascadeGO:0032874480.600
protein processingGO:00164851630.598
Mouse Worm Fly
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.596
Mouse
negative regulation of interleukin 6 productionGO:0032715170.596
positive regulation of transcription factor import into nucleusGO:004299380.594
response to organic cyclic compoundGO:00140701980.594
Mouse
regulation of growth of symbiont in hostGO:0044126190.589
er nucleus signaling pathwayGO:0006984270.585
Mouse
peptide metabolic processGO:0006518460.583
cellular nitrogen compound catabolic processGO:00442702800.577
Mouse
fat soluble vitamin biosynthetic processGO:004236240.570
response to tumor necrosis factorGO:0034612260.570
circadian sleep wake cycleGO:004274550.559
regulation of vitamin d biosynthetic processGO:006055610.556
positive regulation of apoptotic signaling pathwayGO:2001235950.556
Mouse Fly
macromolecule catabolic processGO:00090572810.555
Mouse Worm
negative regulation of cell proliferationGO:00082852960.554
Mouse Fly
positive regulation of phagocytosisGO:0050766260.553
negative regulation of t cell proliferationGO:0042130380.553
Mouse
negative regulation of protein serine threonine kinase activityGO:0071901490.551
Mouse
regulation of nucleotide binding oligomerization domain containing signaling pathwayGO:007042430.551
positive regulation of neutrophil mediated cytotoxicityGO:007096010.547
activation of mapk activity involved in innate immune responseGO:003541920.547
regulation of interleukin 10 productionGO:0032653210.544
macrophage differentiationGO:0030225200.543
Mouse
acute inflammatory responseGO:0002526410.536
dna metabolic processGO:00062593030.536
Mouse
interleukin 18 mediated signaling pathwayGO:003565520.535
regulation of autophagyGO:0010506300.534
Mouse Fly
regulation of reactive oxygen species biosynthetic processGO:190342620.534
reactive nitrogen species metabolic processGO:200105700.533
cytokine metabolic processGO:0042107710.532
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332350.530
myeloid leukocyte activationGO:0002274830.530
positive regulation of interleukin 10 secretionGO:200118110.530
myeloid cell differentiationGO:00300992330.529
Mouse
cellular response to hormone stimulusGO:00328701500.526
Mouse
regulation of interleukin 8 secretionGO:200048220.525
regulation of chemokine secretionGO:009019640.524
positive regulation of neuron deathGO:1901216280.518
Mouse
midgut developmentGO:000749440.516
cell fate commitmentGO:00451652100.516
Mouse
aromatic compound catabolic processGO:00194392860.514
Mouse
regulation of kinase activityGO:00435492490.514
Mouse
response to protozoanGO:0001562280.513
positive regulation of t cell proliferationGO:0042102520.510
protein oligomerizationGO:0051259670.507
Fly
toxin transportGO:1901998380.505
Mouse
negative regulation of growth of symbiont in hostGO:0044130190.504
positive regulation by symbiont of defense related host nitric oxide productionGO:005234710.504
peripheral nervous system neuron differentiationGO:004893490.503
positive regulation of t cell activationGO:00508701010.502
regulation of cellular catabolic processGO:00313292420.501
Mouse Fly
protein modification by small protein conjugation or removalGO:00706472070.499
negative regulation of inflammatory response to antigenic stimulusGO:0002862100.499
negative regulation of molecular functionGO:00440922580.499
Mouse
immunoglobulin productionGO:0002377730.495
monocyte chemotactic protein 1 productionGO:007160510.489
protein complex localizationGO:0031503190.486
regulation of cytoplasmic transportGO:19036491120.486
regulation of protein kinase activityGO:00458592320.486
Mouse
nuclear transportGO:00511691390.484
protein catabolic processGO:00301632210.482
Worm
macrophage activationGO:0042116270.480
positive regulation of antibacterial peptide productionGO:000280310.473
reactive oxygen species metabolic processGO:0072593840.473
regulation of b cell proliferationGO:0030888390.472
Mouse
response to dsrnaGO:0043331300.464
negative regulation of transferase activityGO:0051348850.462
Mouse
regulation of transferase activityGO:00513382630.462
Mouse
positive regulation of release of cytochrome c from mitochondriaGO:009020050.461
regulation of interleukin 8 productionGO:003267730.461
response to peptideGO:19016521360.459
microglial cell activationGO:000177430.456
negative regulation of protein localization to nucleusGO:1900181230.452
positive regulation of nitric oxide synthase biosynthetic processGO:005177060.446
regulation of prostaglandin endoperoxide synthase activityGO:006058420.445
cell surface pattern recognition receptor signaling pathwayGO:000275220.444
inflammatory response to antigenic stimulusGO:0002437300.442
cellular response to dexamethasone stimulusGO:007154980.437
Mouse
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.435
response to corticosteroidGO:0031960200.434
Mouse
heterocycle catabolic processGO:00467002800.432
Mouse
regulation of peptide transportGO:0090087910.428
negative regulation of cell activationGO:00508661110.427
Mouse
positive regulation of cytokine biosynthetic processGO:0042108400.425
organic cyclic compound catabolic processGO:19013612950.425
Mouse
regulation of protein modification by small protein conjugation or removalGO:1903320570.420
interferon gamma productionGO:0032609670.414
negative regulation of myoblast differentiationGO:0045662180.413
regulation of heat generationGO:003165080.411
regulation of fever generationGO:003162060.407
interleukin 18 productionGO:003262140.405
acute phase responseGO:0006953100.402
sensory perception of soundGO:0007605970.401
Mouse
regulation of skeletal muscle fiber developmentGO:0048742360.399
myeloid leukocyte differentiationGO:00025731190.392
Mouse
blood vessel morphogenesisGO:00485142850.386
Mouse
fever generationGO:000166070.385
positive regulation of humoral immune responseGO:0002922110.378
regulation of t cell mediated immunityGO:0002709340.376
neuron deathGO:00709971540.374
Mouse
positive regulation of t helper 1 cell differentiationGO:004562740.367
adhesion of symbiont to hostGO:004440680.366
chemokine secretionGO:009019550.365
immunoglobulin production involved in immunoglobulin mediated immune responseGO:0002381430.356
growth involved in symbiotic interactionGO:0044110230.356
humoral immune responseGO:0006959570.353
regulation of inflammatory response to antigenic stimulusGO:0002861210.353
regulation of fatty acid transportGO:2000191100.352
negative regulation of protein import into nucleusGO:0042308210.352
interleukin 6 secretionGO:007260430.350
syncytium formationGO:0006949430.347
nitrogen compound transportGO:00717052710.343
reactive oxygen species biosynthetic processGO:190340980.342
positive regulation of nucleocytoplasmic transportGO:0046824300.339
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.333
positive regulation of acute inflammatory responseGO:0002675160.333
positive regulation of inflammatory responseGO:0050729470.330
response to ketoneGO:1901654150.329
Mouse
positive regulation of chemokine biosynthetic processGO:004508060.325
striated muscle tissue developmentGO:00147062930.324
cellular response to alcoholGO:0097306230.318
Mouse
lymphocyte homeostasisGO:0002260640.316
Mouse
positive regulation of intracellular protein transportGO:0090316420.314
defense response to fungusGO:0050832120.313
cd4 positive alpha beta t cell differentiation involved in immune responseGO:0002294280.309
regulation of nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007042830.307
t cell homeostasisGO:0043029350.299
Mouse
transcription factor import into nucleusGO:0042991260.298
positive regulation of b cell mediated immunityGO:0002714260.297
positive regulation of interleukin 10 productionGO:0032733120.292
purine containing compound metabolic processGO:00725213110.292
skin developmentGO:00435882200.292
Mouse
t helper 2 cell cytokine productionGO:003574540.291
growth of symbiont in hostGO:0044117230.288
regulation of mitochondrial membrane potentialGO:0051881170.288
Mouse
negative regulation of macrophage apoptotic processGO:200011030.285
cd4 positive alpha beta t cell differentiationGO:0043367410.278
regulation of neuron deathGO:19012141340.275
Mouse
regulation of humoral immune responseGO:0002920220.275
negative regulation of nik nf kappab signalingGO:190122320.274
leukocyte mediated immunityGO:00024431740.273
glycosyl compound catabolic processGO:19016582060.271
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.270
cell type specific apoptotic processGO:00972852680.267
Mouse Fly
angiogenesisGO:00015252010.265
Mouse
positive regulation of nf kappab transcription factor activityGO:0051092300.265
positive regulation of lipopolysaccharide mediated signaling pathwayGO:003166650.263
positive regulation of cytoplasmic transportGO:1903651400.263
induction by organism of immune response of other organism involved in symbiotic interactionGO:005255810.262
antimicrobial humoral responseGO:0019730110.260
positive regulation of multi organism processGO:0043902260.259
positive regulation of syncytium formation by plasma membrane fusionGO:0060143170.257
regulation of response to cytokine stimulusGO:0060759230.256
negative regulation of interferon beta productionGO:003268830.253
negative regulation of nf kappab transcription factor activityGO:0032088150.253
t cell differentiation involved in immune responseGO:0002292300.252
negative regulation of inflammatory responseGO:0050728610.252
positive regulation of fever generationGO:003162260.252
regulation of protein processingGO:0070613960.251
negative regulation of intracellular protein transportGO:0090317270.251
nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007042750.249
nucleic acid phosphodiester bond hydrolysisGO:0090305490.249
Mouse
cellular response to organonitrogen compoundGO:00714171450.248
positive regulation of natural killer cell chemotaxisGO:200050310.248
b cell activation involved in immune responseGO:0002312500.248
regulation of toll like receptor 2 signaling pathwayGO:003413530.247
t cell activation involved in immune responseGO:0002286430.245
response to purine containing compoundGO:0014074280.245
Mouse
myoblast differentiationGO:0045445520.241
t helper 1 type immune responseGO:0042088250.241
response to molecule of fungal originGO:000223840.240
neutrophil mediated killing of fungusGO:007094730.240
innate immune response in mucosaGO:000222730.239
positive regulation of neutrophil mediated killing of fungusGO:007096510.239
regulation of b cell mediated immunityGO:0002712370.239
positive regulation of interleukin 18 productionGO:003274120.236
innate immune response activating cell surface receptor signaling pathwayGO:000222040.236
helper t cell enhancement of adaptive immune responseGO:003539710.233
modulation of growth of symbiont involved in interaction with hostGO:0044144190.231
regulation of body fluid levelsGO:00508781620.231
nucleoside metabolic processGO:00091162460.230
epidermis developmentGO:00085441870.227
Mouse
interleukin 2 productionGO:0032623330.226
interleukin 10 productionGO:0032613230.224
sensory perception of mechanical stimulusGO:00509541070.222
Mouse
regulation of nucleotide metabolic processGO:00061401690.222
positive regulation of behaviorGO:0048520400.220
interferon alpha productionGO:003260770.220
cellular response to abiotic stimulusGO:0071214560.220
t helper cell differentiationGO:0042093280.219
regulation of neutrophil mediated killing of symbiont cellGO:007094920.217
rac protein signal transductionGO:0016601130.215
fatty acid derivative transportGO:1901571140.215
necrotic cell deathGO:0070265300.211
Mouse
response to organonitrogen compoundGO:00102432460.210
Mouse
response to peptidoglycanGO:003249490.210
positive regulation of reactive oxygen species metabolic processGO:2000379110.208
chemokine metabolic processGO:0050755100.207
spermatogenesisGO:00072832840.201
Fly
endoplasmic reticulum unfolded protein responseGO:0030968190.201
Mouse
lymphocyte differentiationGO:00300982420.200
wound healingGO:00420601570.200
negative regulation of erk1 and erk2 cascadeGO:0070373210.199
nik nf kappab signalingGO:0038061140.198
regulation of cellular amide metabolic processGO:0034248100.198
myeloid dendritic cell activationGO:0001773250.197

Casp4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.675
disease of cellular proliferationDOID:1456600.675
organ system cancerDOID:005068600.412