IMP: Integrative Multi-species Prediction

Mus musculus

11 known processes

Cdkn2c

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

(Aliases: p18,INK4d,C77269,p18INK4c,INK4c)

Ensembl: ENSMUSG00000028551
Entrez: 12580
UniProtKB: Q9D153
UniProtKB: Q60772

Process Predictions
Disease Predictions

Cdkn2c biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of cell cycle	GO:0045786	123	0.961	Human
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	9	0.919
regulation of kinase activity	GO:0043549	249	0.904	Human
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.892	Human
regulation of protein kinase activity	GO:0045859	232	0.883	Human
negative regulation of protein phosphorylation	GO:0001933	126	0.784	Human
negative regulation of leukocyte differentiation	GO:1902106	51	0.760	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.691
regulation of cell growth	GO:0001558	91	0.688	Human
lymphocyte differentiation	GO:0030098	242	0.687	Mouse
negative regulation of molecular function	GO:0044092	258	0.674	Human
regulation of cell cycle	GO:0051726	281	0.647	Human
response to extracellular stimulus	GO:0009991	127	0.622
t cell activation	GO:0042110	289	0.616	Mouse
regulation of protein serine threonine kinase activity	GO:0071900	157	0.613	Human
positive regulation of transferase activity	GO:0051347	167	0.581
negative regulation of protein metabolic process	GO:0051248	282	0.567	Human
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.560	Human
negative regulation of cellular protein metabolic process	GO:0032269	247	0.558	Human
regulation of mitotic cell cycle	GO:0007346	126	0.555
cell cycle arrest	GO:0007050	37	0.552	Human
regulation of transferase activity	GO:0051338	263	0.529	Human
cellular response to growth factor stimulus	GO:0071363	197	0.509
mitotic cell cycle process	GO:1903047	159	0.476	Human
intra s dna damage checkpoint	GO:0031573	4	0.464
negative regulation of cell growth	GO:0030308	44	0.464	Human
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.462
regulation of epithelial cell proliferation	GO:0050678	141	0.461	Mouse
negative regulation of transferase activity	GO:0051348	85	0.453	Human
cellular response to antibiotic	GO:0071236	4	0.446
negative regulation of protein modification process	GO:0031400	163	0.440	Human
response to nutrient levels	GO:0031667	109	0.423
dna repair	GO:0006281	107	0.416
regulation of t cell differentiation	GO:0045580	83	0.410	Mouse
negative regulation of t cell differentiation	GO:0045581	23	0.405	Mouse
cellular ketone metabolic process	GO:0042180	84	0.403
negative regulation of growth	GO:0045926	99	0.395	Human
epithelial cell proliferation	GO:0050673	174	0.386	Mouse
regulation of lymphocyte proliferation	GO:0050670	117	0.384
homeostasis of number of cells	GO:0048872	210	0.384
positive regulation of apoptotic process	GO:0043065	217	0.376
intrinsic apoptotic signaling pathway	GO:0097193	132	0.365
forebrain development	GO:0030900	302	0.364
regulation of microtubule based process	GO:0032886	52	0.358
negative regulation of cell cycle phase transition	GO:1901988	48	0.358
cellular senescence	GO:0090398	11	0.347
apoptotic signaling pathway	GO:0097190	306	0.327
g1 s transition of mitotic cell cycle	GO:0000082	57	0.321	Human
response to growth factor	GO:0070848	198	0.318
regulation of cell cycle process	GO:0010564	160	0.317
regulation of b cell proliferation	GO:0030888	39	0.308
t cell differentiation	GO:0030217	174	0.301	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.299	Human
negative regulation of phosphorus metabolic process	GO:0010563	184	0.297	Human
gland development	GO:0048732	330	0.296
cellular response to dna damage stimulus	GO:0006974	207	0.294
regulation of microtubule polymerization	GO:0031113	7	0.285
regulation of organelle organization	GO:0033043	289	0.279
negative regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0071930	1	0.275
regulation of protein processing	GO:0070613	96	0.272
ras protein signal transduction	GO:0007265	77	0.269
negative regulation of kinase activity	GO:0033673	81	0.266	Human
regulation of nucleocytoplasmic transport	GO:0046822	73	0.265
mitotic cell cycle	GO:0000278	195	0.262	Human
positive regulation of programmed cell death	GO:0043068	218	0.244
response to oxidative stress	GO:0006979	123	0.240
cellular amine metabolic process	GO:0044106	44	0.238
negative regulation of mitotic cell cycle	GO:0045930	58	0.236
nucleobase containing small molecule metabolic process	GO:0055086	352	0.234
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.228
positive regulation of myeloid cell apoptotic process	GO:0033034	4	0.223
cellular response to external stimulus	GO:0071496	88	0.222
t cell proliferation	GO:0042098	120	0.220
purine ribonucleotide metabolic process	GO:0009150	290	0.220
regulation of protein stability	GO:0031647	52	0.216
germ cell development	GO:0007281	185	0.215
signal transduction by p53 class mediator	GO:0072331	51	0.201
morphogenesis of a branching structure	GO:0001763	203	0.200	Mouse
cell fate commitment	GO:0045165	210	0.198
positive regulation of apoptotic process involved in mammary gland involution	GO:0060058	4	0.195
regulation of lymphocyte activation	GO:0051249	240	0.194	Mouse
rrna transcription	GO:0009303	9	0.194
male sex differentiation	GO:0046661	109	0.193
negative regulation of protein processing	GO:0010955	79	0.190
myeloid cell apoptotic process	GO:0033028	22	0.189
regionalization	GO:0003002	337	0.185	Mouse
protein maturation	GO:0051604	176	0.184
mitotic cell cycle checkpoint	GO:0007093	31	0.182
response to uv	GO:0009411	44	0.180
regulation of intracellular transport	GO:0032386	159	0.180
actin filament bundle assembly	GO:0051017	40	0.178
regulation of t cell activation	GO:0050863	170	0.177	Mouse
b cell proliferation	GO:0042100	53	0.175
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.173
apoptotic process involved in mammary gland involution	GO:0060057	4	0.169
regulation of cell adhesion	GO:0030155	154	0.168	Mouse
male gamete generation	GO:0048232	285	0.167
cellular response to nutrient levels	GO:0031669	64	0.166
nuclear transport	GO:0051169	139	0.166
regulation of g1 s transition of mitotic cell cycle	GO:2000045	35	0.166
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.164
small gtpase mediated signal transduction	GO:0007264	97	0.164
cell growth	GO:0016049	130	0.164	Human
regulation of cytoskeleton organization	GO:0051493	122	0.162
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.160
regulation of mapk cascade	GO:0043408	248	0.159
purine containing compound catabolic process	GO:0072523	213	0.159
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.157
cellular response to oxidative stress	GO:0034599	76	0.157
lymphocyte proliferation	GO:0046651	164	0.155
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.155
mitotic g1 dna damage checkpoint	GO:0031571	4	0.154
mitotic cell cycle arrest	GO:0071850	4	0.153
dna biosynthetic process	GO:0071897	22	0.153
regulation of cytoplasmic transport	GO:1903649	112	0.153
regulation of lymphocyte differentiation	GO:0045619	107	0.152	Mouse
regulation of cell cycle phase transition	GO:1901987	77	0.151
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.150
ribonucleoside catabolic process	GO:0042454	206	0.150
negative regulation of mammary gland epithelial cell proliferation	GO:0033600	3	0.148
cellular amino acid metabolic process	GO:0006520	103	0.144
maintenance of location	GO:0051235	89	0.144
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	18	0.141
urogenital system development	GO:0001655	261	0.139
nucleoside catabolic process	GO:0009164	206	0.136
regulation of hydrolase activity	GO:0051336	246	0.136
leukocyte differentiation	GO:0002521	342	0.135	Mouse
response to radiation	GO:0009314	165	0.135
signal transduction involved in dna damage checkpoint	GO:0072422	3	0.135
posttranscriptional regulation of gene expression	GO:0010608	155	0.134
nucleocytoplasmic transport	GO:0006913	139	0.134
negative regulation of lymphocyte activation	GO:0051250	91	0.134	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.133	Human
negative regulation of cell activation	GO:0050866	111	0.131	Mouse
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.131
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.128
extrinsic apoptotic signaling pathway	GO:0097191	126	0.125
negative regulation of t cell proliferation	GO:0042130	38	0.124
regulation of protein maturation	GO:1903317	96	0.121
metaphase plate congression	GO:0051310	2	0.121
b cell activation	GO:0042113	161	0.121
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.120
stem cell maintenance	GO:0019827	130	0.120
negative regulation of response to dna damage stimulus	GO:2001021	10	0.119
embryonic organ morphogenesis	GO:0048562	276	0.119
cell aging	GO:0007569	35	0.118
glycosyl compound catabolic process	GO:1901658	206	0.118
regulation of erk1 and erk2 cascade	GO:0070372	71	0.117
regulation of cell activation	GO:0050865	289	0.116	Mouse
t cell differentiation in thymus	GO:0033077	77	0.116
regulation of cellular amine metabolic process	GO:0033238	20	0.115
cellular response to extracellular stimulus	GO:0031668	81	0.115
negative regulation of epithelial cell proliferation	GO:0050680	64	0.115
digestive system development	GO:0055123	200	0.114
cytoplasmic transport	GO:0016482	234	0.114
ribonucleoside metabolic process	GO:0009119	245	0.114
regulation of cellular catabolic process	GO:0031329	242	0.112
positive regulation of proteolysis	GO:0045862	85	0.112
microtubule based process	GO:0007017	236	0.112
ribose phosphate metabolic process	GO:0019693	291	0.111
regulation of protein localization	GO:0032880	231	0.107
regulation of proteolysis	GO:0030162	164	0.106
regulation of cell cycle g1 s phase transition	GO:1902806	35	0.106
ribonucleotide metabolic process	GO:0009259	291	0.106
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:2000058	14	0.105
protein modification by small protein conjugation or removal	GO:0070647	207	0.104
regulation of protein catabolic process	GO:0042176	108	0.103
negative regulation of synaptic vesicle exocytosis	GO:2000301	3	0.102
lipid localization	GO:0010876	126	0.101
cell type specific apoptotic process	GO:0097285	268	0.100
negative regulation of cellular protein catabolic process	GO:1903363	22	0.100
membrane organization	GO:0061024	245	0.099
leukocyte proliferation	GO:0070661	172	0.099
purine nucleoside metabolic process	GO:0042278	241	0.099
negative regulation of lymphocyte differentiation	GO:0045620	32	0.098	Mouse
embryonic axis specification	GO:0000578	30	0.098	Mouse
purine containing compound metabolic process	GO:0072521	311	0.096
myeloid cell differentiation	GO:0030099	233	0.096
cellular nitrogen compound catabolic process	GO:0044270	280	0.096
cellular macromolecule catabolic process	GO:0044265	206	0.096
hematopoietic progenitor cell differentiation	GO:0002244	143	0.095
nucleoside phosphate metabolic process	GO:0006753	338	0.094
mapk cascade	GO:0000165	281	0.094
nucleoside triphosphate metabolic process	GO:0009141	230	0.094
regulation of leukocyte proliferation	GO:0070663	121	0.093
optic placode formation	GO:0001743	2	0.093
positive regulation of apoptotic process involved in morphogenesis	GO:1902339	4	0.091
regulation of feeding behavior	GO:0060259	3	0.091
optic placode formation involved in camera type eye formation	GO:0046619	2	0.090
positive regulation of cell death	GO:0010942	224	0.090
response to light stimulus	GO:0009416	135	0.090
negative regulation of leukocyte proliferation	GO:0070664	46	0.088
purine nucleotide metabolic process	GO:0006163	302	0.088
microtubule cytoskeleton organization	GO:0000226	157	0.088
negative regulation of protein maturation	GO:1903318	79	0.088
heterocycle catabolic process	GO:0046700	280	0.087
positive regulation of cell development	GO:0010720	237	0.087
somitogenesis	GO:0001756	69	0.087	Mouse
regulation of binding	GO:0051098	111	0.086
regulation of neural precursor cell proliferation	GO:2000177	70	0.086
neural precursor cell proliferation	GO:0061351	121	0.085
organic cyclic compound catabolic process	GO:1901361	295	0.085
glucose homeostasis	GO:0042593	128	0.085
gastrulation	GO:0007369	116	0.083
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.083
negative regulation of cellular catabolic process	GO:0031330	47	0.083
prostate gland development	GO:0030850	48	0.082
oxidation reduction process	GO:0055114	342	0.082
cell cycle g1 s phase transition	GO:0044843	57	0.081	Human
dna metabolic process	GO:0006259	303	0.079
camera type eye development	GO:0043010	266	0.079
plasma membrane organization	GO:0007009	90	0.078
response to transforming growth factor beta	GO:0071559	88	0.077
negative regulation of dna replication	GO:0008156	4	0.076
regulation of endopeptidase activity	GO:0052548	89	0.076
regulation of cell substrate adhesion	GO:0010810	73	0.076
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	3	0.075
negative regulation of hydrolase activity	GO:0051346	71	0.075
stem cell proliferation	GO:0072089	117	0.075
negative regulation of proteolysis	GO:0045861	74	0.075
response to organonitrogen compound	GO:0010243	246	0.074
stem cell differentiation	GO:0048863	268	0.074
sprouting angiogenesis	GO:0002040	26	0.074	Mouse
epithelial cell development	GO:0002064	159	0.073
positive regulation of muscle cell apoptotic process	GO:0010661	6	0.072
negative regulation of organ growth	GO:0046621	17	0.072
regulation of microtubule cytoskeleton organization	GO:0070507	37	0.072
lens development in camera type eye	GO:0002088	62	0.071
organ induction	GO:0001759	21	0.071
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902043	13	0.071
response to inorganic substance	GO:0010035	96	0.070
regulation of cellular response to stress	GO:0080135	159	0.070
nucleoside phosphate biosynthetic process	GO:1901293	79	0.070
muscle cell differentiation	GO:0042692	261	0.070
ubiquitin dependent protein catabolic process	GO:0006511	129	0.070
cell division	GO:0051301	120	0.069
carbohydrate homeostasis	GO:0033500	128	0.068
digestive tract development	GO:0048565	190	0.067
signal transduction involved in mitotic dna damage checkpoint	GO:1902402	3	0.066
regulation of organ morphogenesis	GO:2000027	144	0.066
regulation of intracellular protein transport	GO:0033157	82	0.066
regulation of t cell proliferation	GO:0042129	92	0.065
regulation of cohesin localization to chromatin	GO:0071922	1	0.065
regulation of intrinsic apoptotic signaling pathway in response to dna damage	GO:1902229	14	0.065
cation transport	GO:0006812	399	0.065
positive regulation of protein modification process	GO:0031401	299	0.065
megakaryocyte differentiation	GO:0030219	26	0.065
nucleoside phosphate catabolic process	GO:1901292	222	0.065
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	GO:0060527	7	0.065
positive regulation of endothelial cell proliferation	GO:0001938	17	0.064	Mouse
positive regulation of leukocyte apoptotic process	GO:2000108	21	0.064
regulation of vesicle mediated transport	GO:0060627	139	0.064
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.064
spleen development	GO:0048536	39	0.064
regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0000083	3	0.063
negative regulation of lymphocyte proliferation	GO:0050672	45	0.063
positive regulation of microtubule polymerization	GO:0031116	3	0.063
positive regulation of kinase activity	GO:0033674	155	0.063
cellular protein catabolic process	GO:0044257	155	0.062
notch signaling pathway	GO:0007219	71	0.062	Mouse
response to vitamin d	GO:0033280	3	0.062
purine nucleotide catabolic process	GO:0006195	211	0.062
reactive oxygen species metabolic process	GO:0072593	84	0.062
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.062
macromolecule catabolic process	GO:0009057	281	0.062
response to organic cyclic compound	GO:0014070	198	0.061
cellular response to peptide hormone stimulus	GO:0071375	92	0.061
negative regulation of ubiquitin protein transferase activity	GO:0051444	3	0.061
regulation of b cell activation	GO:0050864	81	0.061
cellular lipid metabolic process	GO:0044255	323	0.061
regulation of cell size	GO:0008361	72	0.060
regulation of mammary gland involution	GO:1903519	4	0.060
carbohydrate derivative biosynthetic process	GO:1901137	183	0.059
response to insulin	GO:0032868	100	0.059
regulation of anatomical structure size	GO:0090066	178	0.059
negative regulation of mapk cascade	GO:0043409	65	0.059
negative regulation of cell cycle g1 s phase transition	GO:1902807	18	0.058
regulation of leukocyte apoptotic process	GO:2000106	56	0.058
negative regulation of protein modification by small protein conjugation or removal	GO:1903321	20	0.058
modification dependent protein catabolic process	GO:0019941	133	0.058
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.058
positive regulation of protein kinase activity	GO:0045860	144	0.058
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.057
lymphocyte mediated immunity	GO:0002449	139	0.057
sensory perception	GO:0007600	245	0.057	Mouse
establishment of protein localization to organelle	GO:0072594	118	0.057
cohesin localization to chromatin	GO:0071921	1	0.057
prostate gland epithelium morphogenesis	GO:0060740	31	0.057
regulation of cellular amino acid metabolic process	GO:0006521	5	0.057
protein polymerization	GO:0051258	57	0.057
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.056
regulation of reproductive process	GO:2000241	66	0.056
positive regulation of mapk cascade	GO:0043410	170	0.056
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.056
response to x ray	GO:0010165	11	0.055
oogenesis	GO:0048477	56	0.055
dna damage response signal transduction by p53 class mediator	GO:0030330	19	0.055
regulation of cellular component size	GO:0032535	121	0.055
intracellular protein transport	GO:0006886	204	0.054
pole plasm assembly	GO:0007315	2	0.054
cellular response to lipid	GO:0071396	145	0.054
purine nucleoside catabolic process	GO:0006152	205	0.054
cellular response to starvation	GO:0009267	57	0.054
signal transduction involved in cell cycle checkpoint	GO:0072395	3	0.053
leukocyte mediated immunity	GO:0002443	174	0.053
purine ribonucleotide catabolic process	GO:0009154	208	0.052
positive regulation of macrophage apoptotic process	GO:2000111	3	0.052
nucleotide metabolic process	GO:0009117	332	0.052
regulation of mammary gland epithelial cell proliferation	GO:0033599	12	0.052
morphogenesis of a branching epithelium	GO:0061138	193	0.051	Mouse
regulation of cellular protein catabolic process	GO:1903362	61	0.051
regulation of apoptotic signaling pathway	GO:2001233	197	0.050
regulation of gliogenesis	GO:0014013	50	0.050
ribonucleotide catabolic process	GO:0009261	208	0.050
spermatid differentiation	GO:0048515	115	0.050
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.049
monocarboxylic acid metabolic process	GO:0032787	191	0.049
negative regulation of fibroblast migration	GO:0010764	2	0.049
sensory perception of sound	GO:0007605	97	0.049	Mouse
cellular response to toxic substance	GO:0097237	7	0.049
male gonad development	GO:0008584	88	0.049
response to acid chemical	GO:0001101	111	0.049
response to nutrient	GO:0007584	12	0.048
regulation of leukocyte differentiation	GO:1902105	159	0.048	Mouse
digestive tract morphogenesis	GO:0048546	147	0.048
cerebellum development	GO:0021549	77	0.048
nuclear division	GO:0000280	158	0.048
negative regulation of synaptic vesicle transport	GO:1902804	3	0.048
activation of cysteine type endopeptidase activity	GO:0097202	27	0.048
nuclear import	GO:0051170	95	0.048
organonitrogen compound catabolic process	GO:1901565	264	0.047
protein import	GO:0017038	101	0.047
nucleoside triphosphate catabolic process	GO:0009143	205	0.047
negative regulation of endopeptidase activity	GO:0010951	44	0.047
negative regulation of ligase activity	GO:0051352	3	0.047
cell cell signaling involved in cell fate commitment	GO:0045168	35	0.046
adaptive immune response	GO:0002250	155	0.046
smoothened signaling pathway	GO:0007224	105	0.046
endomembrane system organization	GO:0010256	147	0.046
protein localization to organelle	GO:0033365	185	0.046
lipid storage	GO:0019915	36	0.045
regulation of establishment of protein localization	GO:0070201	181	0.045
positive regulation of hydrolase activity	GO:0051345	148	0.045
regulation of secretion	GO:0051046	274	0.045
meiotic cell cycle	GO:0051321	122	0.045
nucleotide excision repair	GO:0006289	13	0.045
fatty acid biosynthetic process	GO:0006633	41	0.045
response to fibroblast growth factor	GO:0071774	47	0.045
carbohydrate derivative catabolic process	GO:1901136	231	0.045
rho protein signal transduction	GO:0007266	32	0.045
nucleotide catabolic process	GO:0009166	217	0.045
nucleotide biosynthetic process	GO:0009165	78	0.044
dna damage checkpoint	GO:0000077	26	0.044
positive regulation of cellular component biogenesis	GO:0044089	94	0.044
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator	GO:0042771	24	0.044
positive regulation of nucleoside metabolic process	GO:0045979	91	0.044
cellular response to inorganic substance	GO:0071241	37	0.044
positive regulation of map kinase activity	GO:0043406	84	0.044
positive regulation of peptidase activity	GO:0010952	49	0.044
signal transduction involved in dna integrity checkpoint	GO:0072401	3	0.043
regulation of nucleotide biosynthetic process	GO:0030808	34	0.043
regulation of cellular component biogenesis	GO:0044087	181	0.043
regulation of map kinase activity	GO:0043405	120	0.043
organophosphate biosynthetic process	GO:0090407	122	0.043
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.043
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.043
purine ribonucleoside catabolic process	GO:0046130	205	0.043
glycosyl compound metabolic process	GO:1901657	246	0.042
negative regulation of b cell proliferation	GO:0030889	13	0.042
regulation of organ formation	GO:0003156	34	0.042
negative regulation of protein catabolic process	GO:0042177	36	0.042
purine containing compound biosynthetic process	GO:0072522	70	0.042
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.042
nucleoside metabolic process	GO:0009116	246	0.042
negative regulation of tor signaling	GO:0032007	13	0.042
cell cycle checkpoint	GO:0000075	47	0.041
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.041
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.041
regulation of peptidyl serine phosphorylation	GO:0033135	39	0.041
cell cycle g2 m phase transition	GO:0044839	20	0.041
dna integrity checkpoint	GO:0031570	28	0.041
stem cell division	GO:0017145	30	0.041
liver development	GO:0001889	66	0.040
regulation of peptidase activity	GO:0052547	96	0.040
negative regulation of glial cell proliferation	GO:0060253	4	0.040
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.040
regulation of protein localization to nucleus	GO:1900180	60	0.040
protein catabolic process	GO:0030163	221	0.040
response to molecule of bacterial origin	GO:0002237	143	0.039
regulation of protein import into nucleus translocation	GO:0033158	2	0.039
negative regulation of t cell activation	GO:0050868	65	0.039	Mouse
reactive oxygen species biosynthetic process	GO:1903409	8	0.039
development of primary sexual characteristics	GO:0045137	143	0.039
negative regulation of intracellular signal transduction	GO:1902532	167	0.039
cellular homeostasis	GO:0019725	240	0.038
organonitrogen compound biosynthetic process	GO:1901566	192	0.038
regulation of protein transport	GO:0051223	163	0.038
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.038
hippocampus development	GO:0021766	52	0.038
protein localization to nucleus	GO:0034504	121	0.038
positive regulation of cell cycle	GO:0045787	92	0.038
modification dependent macromolecule catabolic process	GO:0043632	133	0.038
fat cell differentiation	GO:0045444	160	0.037
carbohydrate transport	GO:0008643	62	0.037
protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:0042787	25	0.037
protein localization to plasma membrane	GO:0072659	57	0.037
regulation of spindle organization	GO:0090224	2	0.037
regulation of protein binding	GO:0043393	60	0.036
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.036
dopamine uptake	GO:0090494	4	0.036
regulation of phosphoprotein phosphatase activity	GO:0043666	3	0.036
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.036
camp biosynthetic process	GO:0006171	31	0.036
protein processing	GO:0016485	163	0.036
cardiac chamber development	GO:0003205	108	0.036
positive regulation of cellular catabolic process	GO:0031331	148	0.035
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.035
oocyte maturation	GO:0001556	18	0.035
blastoderm segmentation	GO:0007350	13	0.035
establishment of protein localization to membrane	GO:0090150	54	0.035
negative regulation of cell size	GO:0045792	3	0.035
positive regulation of protein phosphorylation	GO:0001934	242	0.035
myotube differentiation	GO:0014902	105	0.035
gtp catabolic process	GO:0006184	143	0.035
regulation of tissue remodeling	GO:0034103	38	0.035
anterior posterior axis specification embryo	GO:0008595	9	0.034
negative regulation of nervous system development	GO:0051961	156	0.034
signal transduction involved in mitotic g1 dna damage checkpoint	GO:0072431	3	0.034
cellularization	GO:0007349	1	0.034
intracellular signal transduction involved in g1 dna damage checkpoint	GO:1902400	3	0.034
erk1 and erk2 cascade	GO:0070371	77	0.034
regulation of synaptic plasticity	GO:0048167	87	0.033
regulation of protein import into nucleus	GO:0042306	52	0.033
monosaccharide transport	GO:0015749	58	0.033
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.033
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.033
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.033
maternal process involved in female pregnancy	GO:0060135	32	0.033
multicellular organism growth	GO:0035264	161	0.033
prostate glandular acinus morphogenesis	GO:0060526	7	0.033
regulation of myeloid cell apoptotic process	GO:0033032	19	0.033
aromatic compound catabolic process	GO:0019439	286	0.032
ear development	GO:0043583	200	0.032
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.032
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.032
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.032
somatic stem cell maintenance	GO:0035019	47	0.032
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.032
positive regulation of mitotic metaphase anaphase transition	GO:0045842	2	0.032
oocyte differentiation	GO:0009994	35	0.032
protein kinase b signaling	GO:0043491	74	0.031
canonical wnt signaling pathway involved in negative regulation of apoptotic process	GO:0044336	4	0.031
trophectodermal cellular morphogenesis	GO:0001831	3	0.031
hexose transport	GO:0008645	56	0.031
dendrite development	GO:0016358	115	0.031
protein localization to chromatin	GO:0071168	3	0.030
dephosphorylation	GO:0016311	129	0.030
organophosphate catabolic process	GO:0046434	232	0.030
regulation of cellular ketone metabolic process	GO:0010565	66	0.030
negative regulation of immune system process	GO:0002683	209	0.030	Mouse
positive regulation of jnk cascade	GO:0046330	46	0.030
regulation of ubiquitin protein transferase activity	GO:0051438	7	0.030
neural tube closure	GO:0001843	90	0.029
regulation of t cell differentiation in thymus	GO:0033081	24	0.029
pallium development	GO:0021543	120	0.029
regulation of response to dna damage stimulus	GO:2001020	34	0.029
protein autophosphorylation	GO:0046777	61	0.029
positive regulation of rap gtpase activity	GO:0032854	3	0.029
intracellular mrna localization	GO:0008298	4	0.029
regulation of homeostatic process	GO:0032844	182	0.029
regulation of mitotic spindle organization	GO:0060236	2	0.029
response to decreased oxygen levels	GO:0036293	59	0.029
protein localization to membrane	GO:0072657	108	0.028
positive regulation of nervous system development	GO:0051962	221	0.028
glial cell apoptotic process	GO:0034349	3	0.028
response to oxygen levels	GO:0070482	62	0.028
positive regulation of nucleotide metabolic process	GO:0045981	114	0.028
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:2000059	6	0.028
camp metabolic process	GO:0046058	40	0.028
cell adhesion	GO:0007155	329	0.028	Mouse
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.028
development of primary male sexual characteristics	GO:0046546	88	0.028
regulation of catecholamine uptake involved in synaptic transmission	GO:0051940	2	0.028
regulation of protein complex assembly	GO:0043254	83	0.027
regulation of ion transport	GO:0043269	215	0.027

Cdkn2c disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.376
organ system cancer	DOID:0050686	0.227
cancer	DOID:162	0.227
respiratory system cancer	DOID:0050615	0.104
lung cancer	DOID:1324	0.104
reproductive organ cancer	DOID:193	0.046
male reproductive organ cancer	DOID:3856	0.046
prostate cancer	DOID:10283	0.046
urinary system cancer	DOID:3996	0.031
disease of metabolism	DOID:0014667	0.031

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