IMP: Integrative Multi-species Prediction

Mus musculus

9 known processes

Cdkn2d

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

(Aliases: INK4d,p19INK4d,p19)

Ensembl: ENSMUSG00000066860
Entrez: 12581
UniProtKB: Q60773
UniProtKB: Q3US51

Process Predictions
Disease Predictions

Cdkn2d biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of transforming growth factor beta secretion	GO:2001203	1	0.999
regulation of transforming growth factor beta secretion	GO:2001201	1	0.998
transforming growth factor beta secretion	GO:0038044	1	0.995
regulation of interleukin 10 secretion	GO:2001179	4	0.967
sensory perception of sound	GO:0007605	97	0.910
sensory perception of mechanical stimulus	GO:0050954	107	0.868
regulation of feeding behavior	GO:0060259	3	0.828
apoptotic signaling pathway	GO:0097190	306	0.821	Human
interleukin 10 secretion	GO:0072608	4	0.819
regulation of brown fat cell proliferation	GO:0070347	1	0.747
negative regulation of cell proliferation	GO:0008285	296	0.652	Human Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.636	Human
brown fat cell proliferation	GO:0070342	1	0.628
regulation of protein localization	GO:0032880	231	0.619
regulation of protein transport	GO:0051223	163	0.587
regulation of protein kinase activity	GO:0045859	232	0.584	Human
cell adhesion	GO:0007155	329	0.547	Mouse
heart morphogenesis	GO:0003007	178	0.538
sensory perception	GO:0007600	245	0.528
intrinsic apoptotic signaling pathway	GO:0097193	132	0.519	Human
regulation of establishment of protein localization	GO:0070201	181	0.492
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.442
cellular amino acid metabolic process	GO:0006520	103	0.441
mitotic cell cycle	GO:0000278	195	0.431	Human
extrinsic apoptotic signaling pathway	GO:0097191	126	0.417
embryonic organ morphogenesis	GO:0048562	276	0.412
negative regulation of feeding behavior	GO:2000252	1	0.412
regulation of protein import into nucleus translocation	GO:0033158	2	0.409
regulation of kinase activity	GO:0043549	249	0.408	Human
response to organonitrogen compound	GO:0010243	246	0.396
energy homeostasis	GO:0097009	15	0.393
lymphocyte differentiation	GO:0030098	242	0.393	Mouse
regionalization	GO:0003002	337	0.374	Mouse
positive regulation of cytokine secretion	GO:0050715	41	0.373
negative regulation of cellular protein metabolic process	GO:0032269	247	0.364	Human
angiogenesis	GO:0001525	201	0.360	Mouse
fat cell proliferation	GO:0070341	4	0.340
mitotic cell cycle process	GO:1903047	159	0.333	Human
regulation of transferase activity	GO:0051338	263	0.320	Human
negative regulation of protein metabolic process	GO:0051248	282	0.306	Human
transepithelial chloride transport	GO:0030321	4	0.302
response to radiation	GO:0009314	165	0.302	Human
ear development	GO:0043583	200	0.301
skeletal system development	GO:0001501	356	0.300
regulation of cytokine production	GO:0001817	266	0.293
multicellular organismal homeostasis	GO:0048871	164	0.285
cellular response to antibiotic	GO:0071236	4	0.282
cellular response to dna damage stimulus	GO:0006974	207	0.280	Human
small gtpase mediated signal transduction	GO:0007264	97	0.263
regulation of cell adhesion	GO:0030155	154	0.261	Mouse
positive regulation of kinase activity	GO:0033674	155	0.261
positive regulation of cytokine production	GO:0001819	174	0.260
t cell activation	GO:0042110	289	0.256	Mouse
cell cycle g1 s phase transition	GO:0044843	57	0.251	Human
positive regulation of apoptotic process	GO:0043065	217	0.247
regulation of mitotic cell cycle	GO:0007346	126	0.235
regulation of homeostatic process	GO:0032844	182	0.232
negative regulation of transferase activity	GO:0051348	85	0.228	Human
regulation of microtubule polymerization	GO:0031113	7	0.227
negative regulation of phosphate metabolic process	GO:0045936	184	0.223	Human
cellular chemical homeostasis	GO:0055082	215	0.213
sensory organ morphogenesis	GO:0090596	242	0.208
regulation of peptidase activity	GO:0052547	96	0.204	Human
negative regulation of brown fat cell proliferation	GO:0070348	1	0.203
retinal cone cell development	GO:0046549	8	0.200
g1 s transition of mitotic cell cycle	GO:0000082	57	0.198	Human
homeostasis of number of cells	GO:0048872	210	0.198
positive regulation of programmed cell death	GO:0043068	218	0.197
regulation of protein secretion	GO:0050708	82	0.195
limb development	GO:0060173	166	0.193
regulation of cytoplasmic transport	GO:1903649	112	0.193
cytokine production	GO:0001816	319	0.187
sperm capacitation	GO:0048240	17	0.187
regulation of nucleocytoplasmic transport	GO:0046822	73	0.186
regulation of intracellular transport	GO:0032386	159	0.184
negative regulation of protein modification process	GO:0031400	163	0.178	Human
negative regulation of kinase activity	GO:0033673	81	0.177	Human
response to light stimulus	GO:0009416	135	0.175	Human
cellular homeostasis	GO:0019725	240	0.174
striated muscle tissue development	GO:0014706	293	0.172
negative regulation of leukocyte differentiation	GO:1902106	51	0.171	Mouse
negative regulation of cell cycle	GO:0045786	123	0.169	Human
cellular response to external stimulus	GO:0071496	88	0.169
cation transport	GO:0006812	399	0.167
digestive system development	GO:0055123	200	0.165
myeloid cell differentiation	GO:0030099	233	0.164
cellular ketone metabolic process	GO:0042180	84	0.163
erythrocyte differentiation	GO:0030218	88	0.163
sulfate transmembrane transport	GO:1902358	3	0.161
negative regulation of phosphorylation	GO:0042326	166	0.161	Human
protein processing	GO:0016485	163	0.160	Human
regulation of cellular amino acid metabolic process	GO:0006521	5	0.159
epithelial cell proliferation	GO:0050673	174	0.159	Mouse
negative regulation of molecular function	GO:0044092	258	0.153	Human
transmission of nerve impulse	GO:0019226	76	0.152
appendage morphogenesis	GO:0035107	149	0.152
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.150	Human
negative regulation of growth	GO:0045926	99	0.150	Human
cellular amine metabolic process	GO:0044106	44	0.149
positive regulation of dipeptide transmembrane transport	GO:2001150	2	0.149
positive regulation of protein secretion	GO:0050714	52	0.148
leukocyte differentiation	GO:0002521	342	0.146	Mouse
sprouting angiogenesis	GO:0002040	26	0.142	Mouse
negative regulation of protein phosphorylation	GO:0001933	126	0.141	Human
regulation of cell cycle	GO:0051726	281	0.140	Human
regulation of leukocyte differentiation	GO:1902105	159	0.139	Mouse
negative regulation of cell growth	GO:0030308	44	0.138	Human
positive regulation of angiogenesis	GO:0045766	46	0.136
cell growth	GO:0016049	130	0.136	Human
negative regulation of behavior	GO:0048521	14	0.136
protein import	GO:0017038	101	0.133
response to lipopolysaccharide	GO:0032496	128	0.133
nucleocytoplasmic transport	GO:0006913	139	0.133
forebrain development	GO:0030900	302	0.133
dipeptide transport	GO:0042938	2	0.130
regulation of lymphocyte activation	GO:0051249	240	0.130	Mouse
regulation of microtubule polymerization or depolymerization	GO:0031110	20	0.127
negative regulation of fat cell proliferation	GO:0070345	2	0.126
regulation of angiogenesis	GO:0045765	81	0.124
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.122
muscle tissue development	GO:0060537	308	0.121
protein localization to chromatin	GO:0071168	3	0.121
response to uv	GO:0009411	44	0.121	Human
cytokine secretion	GO:0050663	72	0.119
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.119
protein secretion	GO:0009306	111	0.118
male gamete generation	GO:0048232	285	0.118
regulation of secretion by cell	GO:1903530	249	0.118
negative regulation of cell activation	GO:0050866	111	0.117	Mouse
signal transduction in absence of ligand	GO:0038034	55	0.117
regulation of cytokine secretion	GO:0050707	61	0.116
ph elevation	GO:0045852	3	0.116
cellular response to lipopolysaccharide	GO:0071222	77	0.116
positive regulation of protein modification process	GO:0031401	299	0.115
regulation of secretion	GO:0051046	274	0.114
regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0000083	3	0.114
negative regulation of cell cycle phase transition	GO:1901988	48	0.113
positive regulation of secretion by cell	GO:1903532	114	0.113
multicellular organismal signaling	GO:0035637	91	0.113
germ cell development	GO:0007281	185	0.111
negative regulation of phosphorus metabolic process	GO:0010563	184	0.111	Human
cellular response to amino acid stimulus	GO:0071230	29	0.109
response to organic cyclic compound	GO:0014070	198	0.108	Human
kidney development	GO:0001822	213	0.108
regulation of cohesin localization to chromatin	GO:0071922	1	0.106
pallium development	GO:0021543	120	0.106
reactive oxygen species metabolic process	GO:0072593	84	0.106
cellular response to oxidative stress	GO:0034599	76	0.105
epithelial tube morphogenesis	GO:0060562	303	0.105	Mouse
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.103
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.102	Human
protein catabolic process	GO:0030163	221	0.102
cell substrate adhesion	GO:0031589	130	0.100
regulation of protein targeting	GO:1903533	61	0.100
single organismal cell cell adhesion	GO:0016337	131	0.099	Mouse
gland development	GO:0048732	330	0.099
positive regulation of protein phosphorylation	GO:0001934	242	0.099
innate immune response	GO:0045087	157	0.099
cohesin localization to chromatin	GO:0071921	1	0.099
regulation of cellular amine metabolic process	GO:0033238	20	0.097
regulation of protein serine threonine kinase activity	GO:0071900	157	0.097	Human
limb morphogenesis	GO:0035108	149	0.097
establishment of protein localization to organelle	GO:0072594	118	0.095
regulation of cellular response to stress	GO:0080135	159	0.094	Human
intracellular protein transport	GO:0006886	204	0.094
microtubule based process	GO:0007017	236	0.092
morphogenesis of a branching structure	GO:0001763	203	0.092	Mouse
inner ear morphogenesis	GO:0042472	101	0.092
cell cycle arrest	GO:0007050	37	0.091	Human
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.090
ossification	GO:0001503	216	0.090
embryonic skeletal system morphogenesis	GO:0048704	91	0.089
protein modification by small protein conjugation or removal	GO:0070647	207	0.089
regulation of neuron apoptotic process	GO:0043523	122	0.088
acid secretion	GO:0046717	33	0.088
negative regulation of mitotic cell cycle	GO:0045930	58	0.088
oxidation reduction process	GO:0055114	342	0.087
dna metabolic process	GO:0006259	303	0.086	Human
cellular response to acid chemical	GO:0071229	68	0.086
morphogenesis of a branching epithelium	GO:0061138	193	0.086	Mouse
regulation of cytoskeleton organization	GO:0051493	122	0.085
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.085
regulation of endopeptidase activity	GO:0052548	89	0.083	Human
regulation of protein import into nucleus	GO:0042306	52	0.083
chloride transport	GO:0006821	32	0.082
regulation of cell motility	GO:2000145	236	0.082
negative regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0071930	1	0.081
microtubule cytoskeleton organization	GO:0000226	157	0.081
regulation of intracellular protein transport	GO:0033157	82	0.081
response to molecule of bacterial origin	GO:0002237	143	0.081
cardiac chamber development	GO:0003205	108	0.081
positive regulation of secretion	GO:0051047	130	0.080
negative regulation of cellular amine metabolic process	GO:0033239	1	0.080
neuron apoptotic process	GO:0051402	142	0.079
oligopeptide transmembrane transport	GO:0035672	4	0.079
regulation of vesicle mediated transport	GO:0060627	139	0.078
interleukin 10 production	GO:0032613	23	0.078
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	9	0.078
somite development	GO:0061053	81	0.077	Mouse
skeletal muscle organ development	GO:0060538	163	0.077
purine containing compound metabolic process	GO:0072521	311	0.076
regulation of vasculature development	GO:1901342	88	0.076
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.076
appendage development	GO:0048736	166	0.076
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.076	Human
cellular response to molecule of bacterial origin	GO:0071219	83	0.075
ion transmembrane transport	GO:0034220	361	0.075
regulation of lipid metabolic process	GO:0019216	118	0.074
cellular response to fructose stimulus	GO:0071332	2	0.074
leukocyte proliferation	GO:0070661	172	0.073
positive regulation of cell death	GO:0010942	224	0.073
acetylcholine transport	GO:0015870	2	0.073
carbohydrate homeostasis	GO:0033500	128	0.073
cellular response to lipid	GO:0071396	145	0.072
regulation of interleukin 10 production	GO:0032653	21	0.072
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.071
positive regulation of cell cycle	GO:0045787	92	0.071
dna repair	GO:0006281	107	0.071	Human
inorganic anion transmembrane transport	GO:0098661	29	0.070
cellular response to cytokine stimulus	GO:0071345	189	0.070
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.070	Human
cell cycle checkpoint	GO:0000075	47	0.069
branching morphogenesis of an epithelial tube	GO:0048754	159	0.069	Mouse
negative regulation of neuron apoptotic process	GO:0043524	92	0.069
positive regulation of organelle organization	GO:0010638	128	0.068
regulation of fat cell proliferation	GO:0070344	4	0.067
spermatogenesis	GO:0007283	284	0.067
regulation of cell growth	GO:0001558	91	0.067	Human
notch signaling pathway	GO:0007219	71	0.067	Mouse
regulation of leukocyte proliferation	GO:0070663	121	0.067
hormone secretion	GO:0046879	128	0.067
cytoplasmic transport	GO:0016482	234	0.067
positive regulation of protein transport	GO:0051222	93	0.067
metal ion homeostasis	GO:0055065	189	0.067
renal system development	GO:0072001	225	0.066
regulation of cell activation	GO:0050865	289	0.066	Mouse
chondrocyte development	GO:0002063	24	0.066
connective tissue development	GO:0061448	179	0.066
posttranscriptional regulation of gene expression	GO:0010608	155	0.065
cellular ion homeostasis	GO:0006873	165	0.065
regulation of cell cycle process	GO:0010564	160	0.065
positive regulation of endothelial cell proliferation	GO:0001938	17	0.065	Mouse
carbohydrate transport	GO:0008643	62	0.065
cell matrix adhesion	GO:0007160	68	0.065
rho protein signal transduction	GO:0007266	32	0.065
nuclear transport	GO:0051169	139	0.065
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.065
translation	GO:0006412	93	0.065
protein localization to nucleus	GO:0034504	121	0.064
regulation of cellular ketone metabolic process	GO:0010565	66	0.064
regulation of transmembrane transport	GO:0034762	128	0.063
multicellular organism growth	GO:0035264	161	0.062
regulation of anatomical structure size	GO:0090066	178	0.062
regulation of protein processing	GO:0070613	96	0.062	Human
regulation of lymphocyte differentiation	GO:0045619	107	0.062	Mouse
sulfur compound transport	GO:0072348	9	0.062
spermatid development	GO:0007286	108	0.062
maintenance of location	GO:0051235	89	0.061
mitotic cell cycle arrest	GO:0071850	4	0.060
spermatid differentiation	GO:0048515	115	0.060
glycoprotein metabolic process	GO:0009100	116	0.060
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.060
myeloid leukocyte differentiation	GO:0002573	119	0.060
lymphocyte proliferation	GO:0046651	164	0.059
cellular calcium ion homeostasis	GO:0006874	119	0.059
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.059
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.058
leukocyte activation involved in immune response	GO:0002366	126	0.058
microtubule polymerization or depolymerization	GO:0031109	26	0.058
cellular modified amino acid metabolic process	GO:0006575	63	0.058
face development	GO:0060324	38	0.057
wound healing	GO:0042060	157	0.057
artery development	GO:0060840	53	0.057
positive regulation of peptidase activity	GO:0010952	49	0.057
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.057
regulation of membrane potential	GO:0042391	192	0.056
regulation of cell cycle phase transition	GO:1901987	77	0.056
immune effector process	GO:0002252	321	0.056
regulation of protein localization to nucleus	GO:1900180	60	0.056
embryonic limb morphogenesis	GO:0030326	126	0.056
macromolecule catabolic process	GO:0009057	281	0.056
cation homeostasis	GO:0055080	212	0.055
cellular response to growth factor stimulus	GO:0071363	197	0.055
extracellular matrix organization	GO:0030198	147	0.055
protein targeting	GO:0006605	143	0.055
b cell activation	GO:0042113	161	0.054
developmental maturation	GO:0021700	193	0.054
adaptive immune response	GO:0002250	155	0.054
synaptic transmission	GO:0007268	329	0.053
positive regulation of protein kinase activity	GO:0045860	144	0.053
regulation of lymphocyte proliferation	GO:0050670	117	0.053
regulation of dipeptide transmembrane transport	GO:2001148	2	0.053
regulation of embryonic development	GO:0045995	71	0.052	Mouse
protein maturation	GO:0051604	176	0.052	Human
embryonic epithelial tube formation	GO:0001838	130	0.052
regulation of mapk cascade	GO:0043408	248	0.052
organic acid transport	GO:0015849	101	0.051
amide transport	GO:0042886	138	0.051
fat cell differentiation	GO:0045444	160	0.051
regulation of proteolysis	GO:0030162	164	0.051	Human
protein localization to organelle	GO:0033365	185	0.050
positive regulation of cellular amine metabolic process	GO:0033240	5	0.050
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.050
cellular response to monosaccharide stimulus	GO:0071326	47	0.050
eye photoreceptor cell development	GO:0042462	31	0.050
activation of cysteine type endopeptidase activity	GO:0097202	27	0.050
inorganic cation transmembrane transport	GO:0098662	207	0.050
regulation of t cell activation	GO:0050863	170	0.050	Mouse
neuron death	GO:0070997	154	0.049
embryonic appendage morphogenesis	GO:0035113	126	0.049
regulation of binding	GO:0051098	111	0.049
protein modification by small protein conjugation	GO:0032446	187	0.049
somitogenesis	GO:0001756	69	0.049	Mouse
peptide transport	GO:0015833	133	0.048
negative regulation of protein processing	GO:0010955	79	0.048	Human
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.048
regulation of triglyceride metabolic process	GO:0090207	17	0.047
response to osmotic stress	GO:0006970	21	0.047
smooth muscle tissue development	GO:0048745	22	0.047
regulation of t cell proliferation	GO:0042129	92	0.046
response to reactive oxygen species	GO:0000302	56	0.046
locomotory behavior	GO:0007626	195	0.046
feeding behavior	GO:0007631	62	0.046
sulfur compound metabolic process	GO:0006790	100	0.046
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.046
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.046	Human
response to oxidative stress	GO:0006979	123	0.045
negative regulation of lymphocyte activation	GO:0051250	91	0.045	Mouse
regulation of microtubule cytoskeleton organization	GO:0070507	37	0.045
positive regulation of ras protein signal transduction	GO:0046579	13	0.045
cellular protein complex assembly	GO:0043623	116	0.045
muscle cell differentiation	GO:0042692	261	0.045
cellular response to extracellular stimulus	GO:0031668	81	0.045
urogenital system development	GO:0001655	261	0.044
positive regulation of transferase activity	GO:0051347	167	0.044
nuclear import	GO:0051170	95	0.044
cellular response to abiotic stimulus	GO:0071214	56	0.043
morphogenesis of embryonic epithelium	GO:0016331	159	0.043
response to monosaccharide	GO:0034284	67	0.043
regulation of neuron differentiation	GO:0045664	281	0.043
carboxylic acid transport	GO:0046942	100	0.043
positive regulation of microtubule polymerization or depolymerization	GO:0031112	3	0.043
positive regulation of microtubule polymerization	GO:0031116	3	0.043
positive regulation of epithelial cell proliferation	GO:0050679	68	0.042	Mouse
response to nutrient levels	GO:0031667	109	0.042	Human
b cell proliferation	GO:0042100	53	0.042
lung development	GO:0030324	164	0.042
camera type eye development	GO:0043010	266	0.041
negative regulation of immune system process	GO:0002683	209	0.041	Mouse
response to ionizing radiation	GO:0010212	42	0.041
intracellular ph elevation	GO:0051454	3	0.041
monocarboxylic acid transport	GO:0015718	44	0.041
regulation of blood vessel size	GO:0050880	56	0.041
positive regulation of proteolysis	GO:0045862	85	0.041
regulation of cell cycle g1 s phase transition	GO:1902806	35	0.041
signal transduction by p53 class mediator	GO:0072331	51	0.041
myeloid cell homeostasis	GO:0002262	114	0.041
regulation of g1 s transition of mitotic cell cycle	GO:2000045	35	0.040
regulation of reproductive process	GO:2000241	66	0.040
monosaccharide metabolic process	GO:0005996	106	0.040
regulation of adaptive immune response	GO:0002819	90	0.040
positive regulation of innate immune response	GO:0045089	80	0.040
microtubule polymerization	GO:0046785	12	0.040
organic anion transport	GO:0015711	137	0.040
macromolecule methylation	GO:0043414	120	0.039
carbohydrate derivative biosynthetic process	GO:1901137	183	0.039
adult walking behavior	GO:0007628	41	0.038
regulation of cellular catabolic process	GO:0031329	242	0.038
central nervous system neuron differentiation	GO:0021953	162	0.038
cell type specific apoptotic process	GO:0097285	268	0.038
regulation of cellular component biogenesis	GO:0044087	181	0.038
renal system process	GO:0003014	48	0.037
organic hydroxy compound transport	GO:0015850	93	0.037
regulation of t cell differentiation	GO:0045580	83	0.037	Mouse
regulation of myeloid cell differentiation	GO:0045637	96	0.037
regulation of oligopeptide transport	GO:0090088	2	0.037
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.037
nuclear division	GO:0000280	158	0.037
cellular response to inorganic substance	GO:0071241	37	0.037
cellular response to biotic stimulus	GO:0071216	92	0.037
response to extracellular stimulus	GO:0009991	127	0.036	Human
lymphocyte mediated immunity	GO:0002449	139	0.036
peptidyl amino acid modification	GO:0018193	336	0.036
regulation of protein catabolic process	GO:0042176	108	0.036
g protein coupled receptor signaling pathway	GO:0007186	243	0.036
protein polymerization	GO:0051258	57	0.036
transmembrane transport	GO:0055085	412	0.036
regulation of cell substrate adhesion	GO:0010810	73	0.036
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.036
intra s dna damage checkpoint	GO:0031573	4	0.036
proteasomal protein catabolic process	GO:0010498	98	0.035
cerebral cortex development	GO:0021987	86	0.035
cellular response to toxic substance	GO:0097237	7	0.035
cell division	GO:0051301	120	0.035
dna damage checkpoint	GO:0000077	26	0.035
skeletal system morphogenesis	GO:0048705	203	0.034
negative regulation of protein transport	GO:0051224	46	0.034
inorganic ion transmembrane transport	GO:0098660	234	0.034
regulation of cartilage development	GO:0061035	44	0.034
negative regulation of intracellular signal transduction	GO:1902532	167	0.034	Human
regulation of cholesterol metabolic process	GO:0090181	14	0.034
cell activation involved in immune response	GO:0002263	126	0.033
stem cell differentiation	GO:0048863	268	0.033
divalent inorganic cation transport	GO:0072511	178	0.033
regulation of hydrolase activity	GO:0051336	246	0.033	Human
blood circulation	GO:0008015	195	0.033
cellular response to organic cyclic compound	GO:0071407	87	0.033
extracellular structure organization	GO:0043062	148	0.033
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.033
cardiac ventricle morphogenesis	GO:0003208	50	0.033
myotube differentiation	GO:0014902	105	0.032
regulation of peptide transport	GO:0090087	91	0.032
positive regulation of binding	GO:0051099	49	0.032
liver development	GO:0001889	66	0.032
organic cyclic compound catabolic process	GO:1901361	295	0.032
regulation of organelle organization	GO:0033043	289	0.032
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.032
single organism nuclear import	GO:1902593	95	0.032
response to growth factor	GO:0070848	198	0.032
nitrogen compound transport	GO:0071705	271	0.031
nucleotide biosynthetic process	GO:0009165	78	0.031
phenol containing compound metabolic process	GO:0018958	60	0.031
cell maturation	GO:0048469	127	0.031
negative regulation of cell migration	GO:0030336	59	0.031
placenta development	GO:0001890	140	0.031
cellular senescence	GO:0090398	11	0.031
mitochondrion organization	GO:0007005	134	0.031
negative regulation of t cell differentiation	GO:0045581	23	0.031	Mouse
ras protein signal transduction	GO:0007265	77	0.031
replicative senescence	GO:0090399	2	0.031
protein kinase b signaling	GO:0043491	74	0.031
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.030	Human
divalent inorganic cation homeostasis	GO:0072507	138	0.030
negative regulation of translation	GO:0017148	22	0.030
response to antibiotic	GO:0046677	11	0.030
positive regulation of dipeptide transport	GO:2000880	2	0.029
modification dependent protein catabolic process	GO:0019941	133	0.029
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.029
hexose metabolic process	GO:0019318	98	0.029
cholesterol homeostasis	GO:0042632	44	0.029
inorganic anion transport	GO:0015698	43	0.029
nucleobase containing small molecule metabolic process	GO:0055086	352	0.029
neural tube development	GO:0021915	160	0.028
regulation of energy homeostasis	GO:2000505	7	0.028
defense response to other organism	GO:0098542	197	0.028
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.028
amine metabolic process	GO:0009308	45	0.028
regulation of b cell activation	GO:0050864	81	0.028
regulation of protein kinase b signaling	GO:0051896	56	0.028
regulation of action potential	GO:0098900	4	0.028
autophagy	GO:0006914	45	0.028
regulation of lipid kinase activity	GO:0043550	14	0.028
chemotaxis	GO:0006935	247	0.028
chloride transmembrane transport	GO:1902476	24	0.028
protein ubiquitination	GO:0016567	171	0.028
dna recombination	GO:0006310	92	0.028
regulation of insulin receptor signaling pathway	GO:0046626	21	0.028
cardiac muscle tissue development	GO:0048738	130	0.028
negative regulation of endothelial cell migration	GO:0010596	4	0.028
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.028
single organism cell adhesion	GO:0098602	156	0.027	Mouse
membrane organization	GO:0061024	245	0.027
acetylcholine secretion neurotransmission	GO:0014055	2	0.027
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	18	0.027
photoreceptor cell development	GO:0042461	40	0.027
t cell proliferation	GO:0042098	120	0.027
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	19	0.027
protein import into nucleus	GO:0006606	95	0.027
regulation of ion transport	GO:0043269	215	0.027
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.027
histone methylation	GO:0016571	71	0.027
positive regulation of cellular component biogenesis	GO:0044089	94	0.026
digestive tract development	GO:0048565	190	0.026
cellular response to carbohydrate stimulus	GO:0071322	50	0.026
ensheathment of neurons	GO:0007272	76	0.026
heterocycle catabolic process	GO:0046700	280	0.026
ear morphogenesis	GO:0042471	118	0.026
positive regulation of mapk cascade	GO:0043410	170	0.026

Cdkn2d disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
sensory system disease	DOID:0050155	0.313
disease of anatomical entity	DOID:7	0.313
nervous system disease	DOID:863	0.313
musculoskeletal system disease	DOID:17	0.111
bone development disease	DOID:0080006	0.098
bone disease	DOID:0080001	0.098
connective tissue disease	DOID:65	0.098
disease of metabolism	DOID:0014667	0.091
central nervous system disease	DOID:331	0.063
brain disease	DOID:936	0.063
cancer	DOID:162	0.047
disease of cellular proliferation	DOID:14566	0.047
organ system cancer	DOID:0050686	0.047
auditory system disease	DOID:2742	0.046
urinary system cancer	DOID:3996	0.040
immune system disease	DOID:2914	0.037
hematopoietic system disease	DOID:74	0.027

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