IMP: Integrative Multi-species Prediction

Mus musculus

20 known processes

Col6a1

collagen, type VI, alpha 1

(Aliases: Col6a-1,AI747156)

Ensembl: ENSMUSG00000001119
Entrez: 12833
UniProtKB: B0LAD9
UniProtKB: Q04857

Process Predictions
Disease Predictions

Col6a1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular response to amino acid stimulus	GO:0071230	29	0.991
extracellular structure organization	GO:0043062	148	0.988
extracellular matrix organization	GO:0030198	147	0.987
response to amino acid	GO:0043200	37	0.978
cellular response to growth factor stimulus	GO:0071363	197	0.813
cell substrate adhesion	GO:0031589	130	0.788
response to organonitrogen compound	GO:0010243	246	0.715
protein trimerization	GO:0070206	13	0.713	Human
regulation of cell adhesion	GO:0030155	154	0.707
regulation of cell substrate adhesion	GO:0010810	73	0.707
fibril organization	GO:0097435	2	0.701
ossification	GO:0001503	216	0.683	Human
connective tissue development	GO:0061448	179	0.674
retinal blood vessel morphogenesis	GO:0061304	3	0.667
response to growth factor	GO:0070848	198	0.646
skeletal system development	GO:0001501	356	0.643
cell matrix adhesion	GO:0007160	68	0.594
cellular response to acid chemical	GO:0071229	68	0.582
palate development	GO:0060021	76	0.562
protein heterotrimerization	GO:0070208	8	0.555	Human
aorta smooth muscle tissue morphogenesis	GO:0060414	2	0.516
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.500
limb bud formation	GO:0060174	10	0.495
regulation of removal of superoxide radicals	GO:2000121	4	0.490
skeletal system morphogenesis	GO:0048705	203	0.480
negative regulation of gastrulation	GO:2000542	3	0.475
cellular response to organonitrogen compound	GO:0071417	145	0.462
positive regulation of ras protein signal transduction	GO:0046579	13	0.455
extrinsic apoptotic signaling pathway	GO:0097191	126	0.445
cell adhesion	GO:0007155	329	0.421
anatomical structure homeostasis	GO:0060249	145	0.400
bone development	GO:0060348	120	0.378
cartilage condensation	GO:0001502	18	0.376
chondrocyte differentiation	GO:0002062	72	0.353
extracellular fibril organization	GO:0043206	2	0.330
lung development	GO:0030324	164	0.319
respiratory tube development	GO:0030323	167	0.303
protein oligomerization	GO:0051259	67	0.290	Human
regulation of apoptotic signaling pathway	GO:2001233	197	0.273
aorta morphogenesis	GO:0035909	22	0.270
response to acid chemical	GO:0001101	111	0.259
protein heterooligomerization	GO:0051291	14	0.251	Human
signal transduction in absence of ligand	GO:0038034	55	0.239
sensory perception of sound	GO:0007605	97	0.232
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.228
regulation of cell motility	GO:2000145	236	0.226
elastic fiber assembly	GO:0048251	4	0.225
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.224
negative regulation of cell adhesion	GO:0007162	45	0.223
head morphogenesis	GO:0060323	34	0.220
positive regulation of cell substrate adhesion	GO:0010811	47	0.216
embryonic organ morphogenesis	GO:0048562	276	0.215
negative regulation of cell substrate adhesion	GO:0010812	16	0.212
limb morphogenesis	GO:0035108	149	0.211
muscle tissue development	GO:0060537	308	0.206
wound healing	GO:0042060	157	0.204
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.202
bone trabecula formation	GO:0060346	9	0.202
cardiac muscle tissue development	GO:0048738	130	0.200
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.196
forebrain development	GO:0030900	302	0.194
replacement ossification	GO:0036075	26	0.191
response to superoxide	GO:0000303	16	0.185
embryonic skeletal system morphogenesis	GO:0048704	91	0.170
proteoglycan metabolic process	GO:0006029	38	0.169
cartilage development	GO:0051216	140	0.166
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.165
negative regulation of tooth mineralization	GO:0070171	1	0.157
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.155
bone morphogenesis	GO:0060349	78	0.153
notochord development	GO:0030903	20	0.153
basement membrane organization	GO:0071711	8	0.150
aorta development	GO:0035904	23	0.149
sensory perception	GO:0007600	245	0.148
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.147
embryonic skeletal system development	GO:0048706	120	0.145
trabecula formation	GO:0060343	24	0.144
protein hydroxylation	GO:0018126	4	0.143
collagen fibril organization	GO:0030199	32	0.136
cellular response to superoxide	GO:0071451	14	0.134
negative regulation of cell migration	GO:0030336	59	0.132
face development	GO:0060324	38	0.131
negative regulation of neuron migration	GO:2001223	6	0.130
trabecula morphogenesis	GO:0061383	40	0.129
cardiac chamber morphogenesis	GO:0003206	93	0.129
response to transforming growth factor beta	GO:0071559	88	0.127
tissue homeostasis	GO:0001894	115	0.126
blood vessel morphogenesis	GO:0048514	285	0.124
skeletal muscle organ development	GO:0060538	163	0.120
heart morphogenesis	GO:0003007	178	0.119
cell aggregation	GO:0098743	18	0.118
regulation of ras protein signal transduction	GO:0046578	114	0.117
growth plate cartilage development	GO:0003417	14	0.116
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.114
direct ossification	GO:0036072	5	0.111
endochondral bone morphogenesis	GO:0060350	50	0.110
regulation of rho protein signal transduction	GO:0035023	71	0.110
cerebral cortex development	GO:0021987	86	0.108
regulation of cell migration	GO:0030334	219	0.105
regulation of peptidase activity	GO:0052547	96	0.102
multicellular organismal homeostasis	GO:0048871	164	0.102
neuron migration	GO:0001764	122	0.101
angiogenesis	GO:0001525	201	0.099
small gtpase mediated signal transduction	GO:0007264	97	0.096
muscle tissue morphogenesis	GO:0060415	53	0.093
regulation of tooth mineralization	GO:0070170	2	0.092
negative regulation of angiogenesis	GO:0016525	25	0.090
limb development	GO:0060173	166	0.090
response to organic cyclic compound	GO:0014070	198	0.089
appendage morphogenesis	GO:0035107	149	0.088
sensory perception of mechanical stimulus	GO:0050954	107	0.088
response to catecholamine	GO:0071869	4	0.084
respiratory system development	GO:0060541	190	0.084
positive regulation of cell adhesion	GO:0045785	80	0.083
nephron development	GO:0072006	109	0.081
digestive system development	GO:0055123	200	0.081	Human
negative regulation of ossification	GO:0030279	49	0.081
artery development	GO:0060840	53	0.081
sensory organ morphogenesis	GO:0090596	242	0.079
cellular response to bmp stimulus	GO:0071773	14	0.078
regulation of proteolysis	GO:0030162	164	0.076
response to inorganic substance	GO:0010035	96	0.075
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	16	0.075
response to decreased oxygen levels	GO:0036293	59	0.073
glycoprotein metabolic process	GO:0009100	116	0.072
cardiac ventricle morphogenesis	GO:0003208	50	0.072
removal of superoxide radicals	GO:0019430	12	0.070
appendage development	GO:0048736	166	0.067
body morphogenesis	GO:0010171	45	0.067
positive regulation of peptidase activity	GO:0010952	49	0.066
regulation of angiogenesis	GO:0045765	81	0.066
collagen biosynthetic process	GO:0032964	7	0.064
regulation of sphingolipid biosynthetic process	GO:0090153	1	0.062
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.061
digestive tract development	GO:0048565	190	0.060	Human
face morphogenesis	GO:0060325	29	0.060
positive regulation of bone remodeling	GO:0046852	13	0.058
renal system development	GO:0072001	225	0.058
collagen metabolic process	GO:0032963	17	0.057
positive regulation of rho protein signal transduction	GO:0035025	7	0.057
negative regulation of immune system process	GO:0002683	209	0.056
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.056
regulation of chondrocyte differentiation	GO:0032330	33	0.056
regulation of neuron projection development	GO:0010975	169	0.056
response to bmp	GO:0071772	14	0.055
reactive oxygen species metabolic process	GO:0072593	84	0.054
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.053
single organism cell adhesion	GO:0098602	156	0.052
negative regulation of signal transduction in absence of ligand	GO:1901099	16	0.051
positive regulation of metanephric mesenchymal cell migration	GO:2000591	1	0.049
negative regulation of cell development	GO:0010721	169	0.048
positive regulation of hydrolase activity	GO:0051345	148	0.048
negative regulation of cell proliferation	GO:0008285	296	0.047
skin development	GO:0043588	220	0.046
ear development	GO:0043583	200	0.045
urogenital system development	GO:0001655	261	0.044
negative regulation of nervous system development	GO:0051961	156	0.044
cardiac muscle tissue morphogenesis	GO:0055008	44	0.044
tendon development	GO:0035989	6	0.043
otic vesicle development	GO:0071599	14	0.043
tissue migration	GO:0090130	68	0.043
gland development	GO:0048732	330	0.043
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.042
rho protein signal transduction	GO:0007266	32	0.042
multicellular organismal catabolic process	GO:0044243	7	0.042
defense response to bacterium	GO:0042742	119	0.042
retinal ganglion cell axon guidance	GO:0031290	18	0.041
chondrocyte development	GO:0002063	24	0.041
spermatogenesis	GO:0007283	284	0.040
extracellular matrix assembly	GO:0085029	12	0.040
negative regulation of cell motility	GO:2000146	61	0.039
insulin metabolic process	GO:1901142	3	0.039
ras protein signal transduction	GO:0007265	77	0.039
regulation of neuron migration	GO:2001222	22	0.039
plasma membrane organization	GO:0007009	90	0.038
positive regulation of cell development	GO:0010720	237	0.038
response to oxidative stress	GO:0006979	123	0.038
pallium development	GO:0021543	120	0.037
regulation of hydrolase activity	GO:0051336	246	0.036
regulation of endodermal cell differentiation	GO:1903224	2	0.036
bone resorption	GO:0045453	38	0.036
cellular response to oxygen radical	GO:0071450	14	0.035
response to peptide hormone	GO:0043434	127	0.035
response to peptide	GO:1901652	136	0.035
positive regulation of axon extension	GO:0045773	20	0.035
antibacterial peptide secretion	GO:0002779	1	0.034
cardiac ventricle development	GO:0003231	83	0.033
response to thyroid hormone	GO:0097066	2	0.033
negative regulation of epithelial cell proliferation	GO:0050680	64	0.032
peptide cross linking via chondroitin 4 sulfate glycosaminoglycan	GO:0019800	8	0.032
regulation of ceramide biosynthetic process	GO:2000303	1	0.031
positive regulation of cell migration	GO:0030335	109	0.031
peptide cross linking	GO:0018149	10	0.031
intussusceptive angiogenesis	GO:0002041	2	0.030
response to monosaccharide	GO:0034284	67	0.030
cell type specific apoptotic process	GO:0097285	268	0.029
positive regulation of bone resorption	GO:0045780	13	0.029
cellular lipid metabolic process	GO:0044255	323	0.029
sequestering of bmp in extracellular matrix	GO:0035582	3	0.028
regulation of hormone levels	GO:0010817	211	0.028
negative regulation of macrophage chemotaxis	GO:0010760	1	0.028
striated muscle tissue development	GO:0014706	293	0.027
muscle cell development	GO:0055001	133	0.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.027
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.027
positive regulation of cell projection organization	GO:0031346	95	0.027
anatomical structure maturation	GO:0071695	49	0.027
regulation of cell projection organization	GO:0031344	206	0.027
synaptic transmission cholinergic	GO:0007271	7	0.027
positive regulation of nervous system development	GO:0051962	221	0.026
antibacterial peptide production	GO:0002778	2	0.026
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.026
cellular response to abiotic stimulus	GO:0071214	56	0.026
antimicrobial peptide secretion	GO:0002776	1	0.025
cellular response to mechanical stimulus	GO:0071260	7	0.025
regionalization	GO:0003002	337	0.025
cellular response to thyroid hormone stimulus	GO:0097067	1	0.025
positive regulation of phospholipase activity	GO:0010518	3	0.025
erythropoietin mediated signaling pathway	GO:0038162	1	0.024
negative regulation of vasculature development	GO:1901343	26	0.024
multicellular organismal macromolecule metabolic process	GO:0044259	19	0.023
inner ear morphogenesis	GO:0042472	101	0.023
positive regulation of apoptotic process	GO:0043065	217	0.023
neuromuscular process controlling balance	GO:0050885	59	0.023
regulation of vasculogenesis	GO:2001212	9	0.022
superoxide metabolic process	GO:0006801	27	0.022
cardiac chamber development	GO:0003205	108	0.022
regulation of cartilage development	GO:0061035	44	0.022
synaptic transmission	GO:0007268	329	0.022
regulation of extent of cell growth	GO:0061387	52	0.022
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.022
notochord cell differentiation	GO:0060034	1	0.021
protein maturation	GO:0051604	176	0.021
negative regulation of growth	GO:0045926	99	0.021
sulfur compound metabolic process	GO:0006790	100	0.021
positive regulation of proteolysis	GO:0045862	85	0.021
cellular response to hormone stimulus	GO:0032870	150	0.021
cellular modified amino acid metabolic process	GO:0006575	63	0.021
oxidation reduction process	GO:0055114	342	0.021
membrane lipid metabolic process	GO:0006643	53	0.021
antimicrobial peptide biosynthetic process	GO:0002777	2	0.020
endothelium development	GO:0003158	45	0.020
regulation of response to reactive oxygen species	GO:1901031	9	0.020
regulation of system process	GO:0044057	200	0.020
telencephalon development	GO:0021537	186	0.020
negative regulation of biomineral tissue development	GO:0070168	11	0.019
axonogenesis	GO:0007409	274	0.019
protein processing	GO:0016485	163	0.019
endothelial cell apoptotic process	GO:0072577	9	0.019
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.019
integrin mediated signaling pathway	GO:0007229	27	0.019
cellular response to fluid shear stress	GO:0071498	4	0.019
regulation of neuron differentiation	GO:0045664	281	0.018
regulation of cellular response to stress	GO:0080135	159	0.018
biomineral tissue development	GO:0031214	64	0.018
developmental programmed cell death	GO:0010623	41	0.018
hormone secretion	GO:0046879	128	0.018
regulation of bone resorption	GO:0045124	24	0.017
vegf activated neuropilin signaling pathway involved in axon guidance	GO:1902378	1	0.017
eye photoreceptor cell development	GO:0042462	31	0.017
positive regulation of cell death	GO:0010942	224	0.017
negative regulation of bmp signaling pathway	GO:0030514	35	0.017
chondroitin sulfate metabolic process	GO:0030204	17	0.017
response to monoamine	GO:0071867	4	0.017
peptidyl amino acid modification	GO:0018193	336	0.017
regulation of organelle organization	GO:0033043	289	0.017
innate immune response	GO:0045087	157	0.017
regulation of macrophage migration inhibitory factor signaling pathway	GO:2000446	1	0.016
epithelial tube morphogenesis	GO:0060562	303	0.016
ventricular cardiac muscle tissue development	GO:0003229	38	0.016
retina development in camera type eye	GO:0060041	119	0.016
positive regulation of programmed cell death	GO:0043068	218	0.016
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway	GO:0035793	1	0.016
regulation of cellular response to oxidative stress	GO:1900407	19	0.016
response to reactive oxygen species	GO:0000302	56	0.016
chondroitin sulfate proteoglycan metabolic process	GO:0050654	20	0.016
regulation of cellular amine metabolic process	GO:0033238	20	0.015
regulation of macrophage chemotaxis	GO:0010758	8	0.015
ear morphogenesis	GO:0042471	118	0.015
myeloid leukocyte migration	GO:0097529	57	0.015
metal ion homeostasis	GO:0055065	189	0.015
defense response to other organism	GO:0098542	197	0.015
regulation of synaptic vesicle priming	GO:0010807	4	0.015
chemotaxis	GO:0006935	247	0.015
ameboidal type cell migration	GO:0001667	128	0.015
synapse organization	GO:0050808	125	0.015
cell adhesion mediated by integrin	GO:0033627	18	0.014
cellular response to external stimulus	GO:0071496	88	0.014
cellular response to nitric oxide	GO:0071732	4	0.014
insulin processing	GO:0030070	2	0.014
male gamete generation	GO:0048232	285	0.014
regulation of transmission of nerve impulse	GO:0051969	1	0.014
cardiac muscle cell development	GO:0055013	39	0.014
regulation of secretion by cell	GO:1903530	249	0.014
oviduct development	GO:0060066	3	0.014
bmp signaling pathway	GO:0030509	93	0.014
cell recognition	GO:0008037	83	0.013
regulation of endopeptidase activity	GO:0052548	89	0.013
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.013
negative regulation of endodermal cell differentiation	GO:1903225	1	0.013
peripheral nervous system axon regeneration	GO:0014012	2	0.013
divalent metal ion transport	GO:0070838	172	0.013
apoptotic signaling pathway	GO:0097190	306	0.013
positive regulation of growth	GO:0045927	104	0.012
organonitrogen compound biosynthetic process	GO:1901566	192	0.012
endothelial cell migration	GO:0043542	44	0.012
odontogenesis	GO:0042476	78	0.012
lung alveolus development	GO:0048286	45	0.012
regulation of axon extension	GO:0030516	43	0.012
regulation of gastrulation	GO:0010470	16	0.012
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway	GO:1900238	1	0.012
positive regulation of insulin secretion	GO:0032024	26	0.012
response to radiation	GO:0009314	165	0.012
sperm egg recognition	GO:0035036	37	0.012
endochondral bone growth	GO:0003416	19	0.012
tissue remodeling	GO:0048771	102	0.012
gastrulation	GO:0007369	116	0.012	Human
cellular ketone metabolic process	GO:0042180	84	0.012
response to increased oxygen levels	GO:0036296	2	0.012
metanephric glomerular basement membrane development	GO:0072274	1	0.012
regulation of secretion	GO:0051046	274	0.012
salivary gland development	GO:0007431	37	0.011
developmental growth involved in morphogenesis	GO:0060560	138	0.011
bone trabecula morphogenesis	GO:0061430	12	0.011
peptide hormone secretion	GO:0030072	109	0.011
developmental maturation	GO:0021700	193	0.011
cardiac cell development	GO:0055006	41	0.011
cellular response to oxidative stress	GO:0034599	76	0.011
notch signaling pathway	GO:0007219	71	0.011
protein catabolic process	GO:0030163	221	0.011
response to steroid hormone	GO:0048545	56	0.011
macrophage colony stimulating factor signaling pathway	GO:0038145	2	0.011
telencephalon cell migration	GO:0022029	55	0.011
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.011
positive regulation of neuron projection development	GO:0010976	79	0.011
cell cell adhesion	GO:0098609	41	0.011
cellular response to dna damage stimulus	GO:0006974	207	0.011
protein autoprocessing	GO:0016540	2	0.011
regulation of multi organism process	GO:0043900	111	0.011
metanephric glomerular mesangial cell proliferation involved in metanephros development	GO:0072262	3	0.011
medulla oblongata development	GO:0021550	3	0.011
placenta blood vessel development	GO:0060674	31	0.011
wound healing spreading of cells	GO:0044319	8	0.011
renal system vasculature development	GO:0061437	15	0.011
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.011
homeostasis of number of cells	GO:0048872	210	0.011
antibacterial peptide biosynthetic process	GO:0002780	2	0.011
meiotic cell cycle process	GO:1903046	77	0.011
neuron death	GO:0070997	154	0.010
regulation of neuron death	GO:1901214	134	0.010
hair follicle morphogenesis	GO:0031069	29	0.010
regulation of cell size	GO:0008361	72	0.010
negative regulation of neuron death	GO:1901215	98	0.010
regulation of biomineral tissue development	GO:0070167	33	0.010
regulation of lipase activity	GO:0060191	15	0.010
sprouting angiogenesis	GO:0002040	26	0.010
macrophage migration inhibitory factor signaling pathway	GO:0035691	2	0.010
response to erythropoietin	GO:0036017	1	0.010
endocytosis	GO:0006897	168	0.010
positive regulation of cell motility	GO:2000147	116	0.010
digestive tract morphogenesis	GO:0048546	147	0.010	Human

Col6a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.976	Human
musculoskeletal system disease	DOID:17	0.976	Human
myopathy	DOID:423	0.976	Human
muscle tissue disease	DOID:66	0.976	Human
muscular disease	DOID:0080000	0.976	Human
connective tissue disease	DOID:65	0.792
bone development disease	DOID:0080006	0.792
osteochondrodysplasia	DOID:2256	0.792
bone disease	DOID:0080001	0.792
muscular dystrophy	DOID:9884	0.602	Human
ehlers danlos syndrome	DOID:13359	0.552
collagen disease	DOID:854	0.552
congenital muscular dystrophy	DOID:0050557	0.426	Human
cardiovascular system disease	DOID:1287	0.067
heart disease	DOID:114	0.067
osteogenesis imperfecta	DOID:12347	0.060
osteoporosis	DOID:11476	0.060
bone resorption disease	DOID:0080011	0.060
bone remodeling disease	DOID:0080005	0.060
eye and adnexa disease	DOID:1492	0.015
retinal degeneration	DOID:8466	0.015
eye disease	DOID:5614	0.015
retinal disease	DOID:5679	0.015
sensory system disease	DOID:0050155	0.015
nervous system disease	DOID:863	0.015

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