IMP: Integrative Multi-species Prediction

Mus musculus

110 known processes

Crebbp

CREB binding protein

(Aliases: KAT3A,CBP,CBP/p300,p300/CBP,AW558298)

Entrez: 12914
Ensembl: ENSMUSG00000022521
UniProtKB: F8VPR5
UniProtKB: Q6GQV9

Process Predictions
Disease Predictions

Crebbp biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
histone modification	GO:0016570	159	0.997
covalent chromatin modification	GO:0016569	163	0.994
histone methylation	GO:0016571	71	0.993
chromatin modification	GO:0016568	187	0.990
chromatin organization	GO:0006325	206	0.980
regionalization	GO:0003002	337	0.973	Mouse
regulation of histone methylation	GO:0031060	30	0.967
dna metabolic process	GO:0006259	303	0.958
histone lysine methylation	GO:0034968	50	0.957
stem cell fate specification	GO:0048866	3	0.950
histone h4 acetylation	GO:0043967	10	0.901
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.898
dna methylation involved in gamete generation	GO:0043046	15	0.890
blastocyst development	GO:0001824	80	0.848
methylation	GO:0032259	134	0.843
positive regulation of dna templated transcription elongation	GO:0032786	2	0.839
peptidyl lysine modification	GO:0018205	77	0.826
myeloid cell differentiation	GO:0030099	233	0.821
peptidyl lysine acetylation	GO:0018394	45	0.814
histone h3 acetylation	GO:0043966	14	0.811
protein methylation	GO:0006479	81	0.779
macromolecule methylation	GO:0043414	120	0.778
cellular response to dna damage stimulus	GO:0006974	207	0.770
dna methylation	GO:0006306	43	0.762
peptidyl amino acid modification	GO:0018193	336	0.761
spermatogenesis	GO:0007283	284	0.751	Worm
regulation of histone modification	GO:0031056	56	0.740
protein dna complex subunit organization	GO:0071824	28	0.737
histone acetylation	GO:0016573	41	0.723
embryonic placenta development	GO:0001892	98	0.698
skeletal system development	GO:0001501	356	0.679
protein alkylation	GO:0008213	81	0.678
regulation of chromosome organization	GO:0033044	83	0.646
response to organonitrogen compound	GO:0010243	246	0.639
hypermethylation of cpg island	GO:0044027	3	0.632
canonical wnt signaling pathway	GO:0060070	130	0.605
cell cycle checkpoint	GO:0000075	47	0.582
regulation of cellular amine metabolic process	GO:0033238	20	0.580
regulation of cardiac cell fate specification	GO:2000043	1	0.563
internal protein amino acid acetylation	GO:0006475	42	0.515
forebrain development	GO:0030900	302	0.510
leukocyte differentiation	GO:0002521	342	0.498
rhythmic process	GO:0048511	174	0.494	Mouse
histone h3 k4 methylation	GO:0051568	23	0.485
regulation of histone h3 k9 methylation	GO:0051570	8	0.469
myeloid cell homeostasis	GO:0002262	114	0.461
respiratory tube development	GO:0030323	167	0.457	Mouse
regulation of chromatin modification	GO:1903308	57	0.435
male gamete generation	GO:0048232	285	0.418	Worm
negative regulation of cell proliferation	GO:0008285	296	0.414
protein acylation	GO:0043543	64	0.402
t cell differentiation	GO:0030217	174	0.395
negative regulation of intracellular signal transduction	GO:1902532	167	0.394
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.392
negative regulation of cell fate specification	GO:0009996	4	0.389
macromolecule catabolic process	GO:0009057	281	0.386
olfactory learning	GO:0008355	2	0.383
regulation of feeding behavior	GO:0060259	3	0.382
gene silencing	GO:0016458	38	0.358
dna alkylation	GO:0006305	43	0.357
myeloid leukocyte differentiation	GO:0002573	119	0.351
digestive system development	GO:0055123	200	0.338
cellular ketone metabolic process	GO:0042180	84	0.329
cardiac cell fate specification	GO:0060912	2	0.319
muscle tissue development	GO:0060537	308	0.318	Mouse
gland development	GO:0048732	330	0.314
regulation of cellular component size	GO:0032535	121	0.310
negative regulation of cell cycle	GO:0045786	123	0.308
wnt signaling pathway	GO:0016055	188	0.293
negative regulation of protein metabolic process	GO:0051248	282	0.289
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter	GO:0072364	7	0.288
mammary gland epithelium development	GO:0061180	65	0.288
mesoderm development	GO:0007498	100	0.282
regulation of transcription during meiosis	GO:0051037	1	0.280
chromatin silencing	GO:0006342	15	0.266
circadian rhythm	GO:0007623	114	0.262	Mouse
skeletal system morphogenesis	GO:0048705	203	0.253
response to peptide hormone	GO:0043434	127	0.249
regulation of chromatin organization	GO:1902275	57	0.246
regulation of organelle organization	GO:0033043	289	0.242
sensory organ morphogenesis	GO:0090596	242	0.240
digestive tract morphogenesis	GO:0048546	147	0.237
positive regulation of chromatin modification	GO:1903310	28	0.236
cytokine production	GO:0001816	319	0.236
endomembrane system organization	GO:0010256	147	0.235
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.233
male meiosis	GO:0007140	37	0.233
hepaticobiliary system development	GO:0061008	67	0.229
multicellular organism growth	GO:0035264	161	0.226
histone h4 k12 acetylation	GO:0043983	2	0.224
regulation of cell cycle process	GO:0010564	160	0.224
erythrocyte differentiation	GO:0030218	88	0.222
learning or memory	GO:0007611	148	0.222
cognition	GO:0050890	149	0.220
i kappab kinase nf kappab signaling	GO:0007249	85	0.220
apoptotic signaling pathway	GO:0097190	306	0.215
positive regulation of transcription from rna polymerase ii promoter in response to stress	GO:0036003	3	0.215
histone h4 k16 acetylation	GO:0043984	3	0.214
embryonic organ morphogenesis	GO:0048562	276	0.210
dna modification	GO:0006304	50	0.207
cellular carbohydrate metabolic process	GO:0044262	119	0.206
camera type eye development	GO:0043010	266	0.204
dna integrity checkpoint	GO:0031570	28	0.199
stem cell maintenance	GO:0019827	130	0.193
respiratory system development	GO:0060541	190	0.188	Mouse
axonogenesis	GO:0007409	274	0.184
histone h3 k14 acetylation	GO:0044154	3	0.183
regulation of organ morphogenesis	GO:2000027	144	0.180
negative regulation of cell size	GO:0045792	3	0.171
regulation of cellular amino acid metabolic process	GO:0006521	5	0.171
peptidyl lysine methylation	GO:0018022	29	0.168
regulation of body fluid levels	GO:0050878	162	0.167
neural tube formation	GO:0001841	108	0.167
regulation of cell cycle	GO:0051726	281	0.156
stem cell differentiation	GO:0048863	268	0.154
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.153
protein modification by small protein conjugation or removal	GO:0070647	207	0.153
positive regulation of leukocyte differentiation	GO:1902107	86	0.153
bmp signaling pathway	GO:0030509	93	0.152
neural tube development	GO:0021915	160	0.151
positive regulation of histone modification	GO:0031058	28	0.150
germ cell development	GO:0007281	185	0.149	Worm
placenta development	GO:0001890	140	0.147
maintenance of chromatin silencing	GO:0006344	2	0.147
negative regulation of protein modification process	GO:0031400	163	0.146
cell fate specification	GO:0001708	72	0.146
cellular response to organonitrogen compound	GO:0071417	145	0.146
regulation of histone h3 k4 methylation	GO:0051569	12	0.146
extrinsic apoptotic signaling pathway	GO:0097191	126	0.144
positive regulation of chromosome organization	GO:2001252	33	0.144
blastocyst formation	GO:0001825	33	0.142
negative regulation of chromosome organization	GO:2001251	30	0.142
chemotaxis	GO:0006935	247	0.142
digestive tract development	GO:0048565	190	0.140
negative regulation of cellular protein metabolic process	GO:0032269	247	0.140
positive regulation of histone h3 k9 methylation	GO:0051574	4	0.138
regulation of fat cell differentiation	GO:0045598	81	0.137
posttranscriptional regulation of gene expression	GO:0010608	155	0.135
segmentation	GO:0035282	93	0.133	Mouse
formation of primary germ layer	GO:0001704	77	0.130
locomotor rhythm	GO:0045475	8	0.128
epithelial tube formation	GO:0072175	130	0.128
negative regulation of epithelial cell proliferation	GO:0050680	64	0.126
mitotic cell cycle process	GO:1903047	159	0.126
dendrite development	GO:0016358	115	0.123
transcription elongation from rna polymerase ii promoter	GO:0006368	9	0.123
external genitalia morphogenesis	GO:0035261	1	0.121
intracellular receptor signaling pathway	GO:0030522	74	0.120
morphogenesis of embryonic epithelium	GO:0016331	159	0.119
primary neural tube formation	GO:0014020	95	0.118
regulation of cell size	GO:0008361	72	0.118
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	2	0.118
embryonic skeletal system development	GO:0048706	120	0.118
regulation of gluconeogenesis by regulation of transcription from rna polymerase ii promoter	GO:0035947	7	0.116
regulation of cell cycle phase transition	GO:1901987	77	0.115
regulation of dna templated transcription in response to stress	GO:0043620	9	0.115
amine metabolic process	GO:0009308	45	0.114
nodal signaling pathway involved in determination of left right asymmetry	GO:0038107	2	0.114
response to transforming growth factor beta	GO:0071559	88	0.113
gastrulation	GO:0007369	116	0.113
regulation of bmp signaling pathway	GO:0030510	60	0.112
negative regulation of phosphorylation	GO:0042326	166	0.112
artery development	GO:0060840	53	0.112
mammary gland morphogenesis	GO:0060443	54	0.111
oocyte differentiation	GO:0009994	35	0.110
homeostasis of number of cells	GO:0048872	210	0.110
gonad development	GO:0008406	141	0.110
phagocytosis	GO:0006909	66	0.109
regulation of response to drug	GO:2001023	2	0.109
neuroblast fate commitment	GO:0014017	1	0.109
stem cell fate commitment	GO:0048865	5	0.109
negative regulation of mesenchymal cell proliferation	GO:0072201	3	0.108
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry	GO:1900164	2	0.107
regulation of defense response to bacterium	GO:1900424	3	0.107
protein modification by small protein conjugation	GO:0032446	187	0.106
reactive oxygen species metabolic process	GO:0072593	84	0.105
negative regulation of gene expression epigenetic	GO:0045814	15	0.105
neural tube closure	GO:0001843	90	0.104
limb development	GO:0060173	166	0.102
innate immune response	GO:0045087	157	0.102
jak stat cascade	GO:0007259	42	0.100
serine phosphorylation of stat protein	GO:0042501	3	0.098
positive regulation of histone methylation	GO:0031062	16	0.097
male meiosis i	GO:0007141	16	0.096
regulation of cardioblast differentiation	GO:0051890	3	0.095
appendage development	GO:0048736	166	0.094
t cell activation	GO:0042110	289	0.093
negative regulation of cell cycle phase transition	GO:1901988	48	0.093
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.093
germ line stem cell division	GO:0042078	2	0.092
cellular response to hormone stimulus	GO:0032870	150	0.092
somite development	GO:0061053	81	0.092	Mouse
regulation of anatomical structure size	GO:0090066	178	0.092
hair cycle	GO:0042633	90	0.092
positive regulation of gene silencing by mirna	GO:2000637	1	0.091
embryonic epithelial tube formation	GO:0001838	130	0.091
somatic diversification of t cell receptor genes	GO:0002568	5	0.091
skeletal muscle cell differentiation	GO:0035914	66	0.090
granulocyte differentiation	GO:0030851	17	0.090
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.089
oogenesis	GO:0048477	56	0.088	Worm
ovarian follicle development	GO:0001541	40	0.086
response to inorganic substance	GO:0010035	96	0.086
face development	GO:0060324	38	0.086
gene silencing by mirna	GO:0035195	10	0.085
lymphocyte differentiation	GO:0030098	242	0.085
response to peptide	GO:1901652	136	0.085
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.084
regulation of chromatin silencing	GO:0031935	2	0.084
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.083
epithelial tube morphogenesis	GO:0060562	303	0.083
limb morphogenesis	GO:0035108	149	0.083
regulation of dna templated transcription elongation	GO:0032784	10	0.082
defense response to bacterium	GO:0042742	119	0.082
gene silencing by rna	GO:0031047	19	0.082
cartilage development	GO:0051216	140	0.080
n terminal protein amino acid modification	GO:0031365	6	0.079	Human
zygotic determination of anterior posterior axis embryo	GO:0007354	3	0.079
carbohydrate metabolic process	GO:0005975	230	0.079
response to estrogen	GO:0043627	24	0.079
positive regulation of cellular amine metabolic process	GO:0033240	5	0.078
organonitrogen compound biosynthetic process	GO:1901566	192	0.078
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.077
synaptic transmission	GO:0007268	329	0.077
lipid localization	GO:0010876	126	0.076	Worm
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.076
regulation of secretion by cell	GO:1903530	249	0.075
response to nitric oxide	GO:0071731	4	0.074
negative regulation of phosphorus metabolic process	GO:0010563	184	0.074
regulation of glucose metabolic process	GO:0010906	60	0.074
positive regulation of cell proliferation involved in heart valve morphogenesis	GO:0003251	1	0.073
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.073
compound eye development	GO:0048749	1	0.073
regulation of neural precursor cell proliferation	GO:2000177	70	0.073
signal transduction in absence of ligand	GO:0038034	55	0.073
glucose homeostasis	GO:0042593	128	0.072
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	1	0.072
liver development	GO:0001889	66	0.072
trophectodermal cell differentiation	GO:0001829	21	0.071
protein deacetylation	GO:0006476	32	0.070
negative regulation of growth	GO:0045926	99	0.069
histone h3 k4 trimethylation	GO:0080182	5	0.069
protein ubiquitination	GO:0016567	171	0.068
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.068
mitotic cell cycle checkpoint	GO:0007093	31	0.068
cellular amino acid metabolic process	GO:0006520	103	0.068
positive regulation of neuron death	GO:1901216	28	0.068
schwann cell proliferation	GO:0014010	2	0.068
regulation of circadian rhythm	GO:0042752	58	0.068
negative regulation of chromatin silencing	GO:0031936	1	0.067
internal peptidyl lysine acetylation	GO:0018393	42	0.067
stem cell development	GO:0048864	219	0.067
regulation of cell cycle checkpoint	GO:1901976	9	0.066
epithalamus development	GO:0021538	2	0.065
regulation of stem cell differentiation	GO:2000736	50	0.065
spermatid differentiation	GO:0048515	115	0.065
mitotic sister chromatid cohesion	GO:0007064	1	0.065
monosaccharide biosynthetic process	GO:0046364	44	0.064
mammary gland duct morphogenesis	GO:0060603	38	0.064
gall bladder development	GO:0061010	2	0.063
lung development	GO:0030324	164	0.063	Mouse
microtubule based process	GO:0007017	236	0.063
ossification	GO:0001503	216	0.063
embryonic skeletal system morphogenesis	GO:0048704	91	0.063
response to hyperoxia	GO:0055093	2	0.062
cardiocyte differentiation	GO:0035051	87	0.062
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis	GO:2000166	1	0.062
regulation of dna damage checkpoint	GO:2000001	3	0.062
stress activated mapk cascade	GO:0051403	80	0.060
histone h3 k9 methylation	GO:0051567	17	0.060
positive regulation of binding	GO:0051099	49	0.059	Mouse
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.059
erbb signaling pathway	GO:0038127	32	0.059
regulation of cytokine production	GO:0001817	266	0.059
lipid biosynthetic process	GO:0008610	179	0.059
hexose metabolic process	GO:0019318	98	0.059
negative regulation of cell cycle process	GO:0010948	69	0.058
chromatin silencing at rdna	GO:0000183	3	0.058
regulation of wnt signaling pathway	GO:0030111	123	0.058
regulation of transcription involved in primary germ layer cell fate commitment	GO:0060796	2	0.057
regulation of protein catabolic process	GO:0042176	108	0.057
positive regulation of mesoderm development	GO:2000382	2	0.057
endocytosis	GO:0006897	168	0.057
synapse organization	GO:0050808	125	0.057
negative regulation of mitotic cell cycle	GO:0045930	58	0.057
mrna metabolic process	GO:0016071	84	0.057
nucleosome positioning	GO:0016584	4	0.057
branching involved in mammary gland duct morphogenesis	GO:0060444	27	0.056
regulation of transcription involved in cell fate commitment	GO:0060850	15	0.056
embryonic camera type eye development	GO:0031076	36	0.055
memory	GO:0007613	58	0.055
osteoclast differentiation	GO:0030316	62	0.055
hexose biosynthetic process	GO:0019319	39	0.054
female gamete generation	GO:0007292	74	0.054	Worm
negative regulation of mapk cascade	GO:0043409	65	0.054
regulation of apoptotic signaling pathway	GO:2001233	197	0.054
negative regulation of phosphate metabolic process	GO:0045936	184	0.054
type i pneumocyte differentiation	GO:0060509	7	0.052
carbohydrate homeostasis	GO:0033500	128	0.052
regulation of response to wounding	GO:1903034	189	0.052
central nervous system neuron differentiation	GO:0021953	162	0.052
negative regulation of molecular function	GO:0044092	258	0.052
negative regulation of nfat protein import into nucleus	GO:0051534	3	0.052
regulation of leukocyte differentiation	GO:1902105	159	0.052
appendage morphogenesis	GO:0035107	149	0.051
dna templated transcription elongation	GO:0006354	13	0.051
nitrogen compound transport	GO:0071705	271	0.051
bmp signaling pathway involved in mesodermal cell fate specification	GO:0060803	1	0.051
regulation of mitotic cell cycle	GO:0007346	126	0.051
carbon catabolite activation of transcription from rna polymerase ii promoter	GO:0000436	4	0.050
mammary gland epithelial cell proliferation	GO:0033598	24	0.050
generation of precursor metabolites and energy	GO:0006091	103	0.050
lipid storage	GO:0019915	36	0.050	Worm
positive regulation of myeloid cell differentiation	GO:0045639	43	0.050
tube formation	GO:0035148	140	0.050
regulation of gluconeogenesis	GO:0006111	30	0.049
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.049
regulation of protein complex assembly	GO:0043254	83	0.049
dna hypermethylation	GO:0044026	3	0.049
regulation of protein stability	GO:0031647	52	0.049
macromolecule deacylation	GO:0098732	37	0.049
response to organic cyclic compound	GO:0014070	198	0.048
lung epithelium development	GO:0060428	37	0.048
regulation of binding	GO:0051098	111	0.048	Mouse
regulation of innate immune response	GO:0045088	91	0.048
body fluid secretion	GO:0007589	53	0.047
genitalia development	GO:0048806	37	0.047
nucleotide metabolic process	GO:0009117	332	0.047
positive regulation of wnt signaling pathway	GO:0030177	45	0.047
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.046
metanephric mesenchyme morphogenesis	GO:0072133	4	0.046
regulation of autophagy	GO:0010506	30	0.046
cellular response to organic cyclic compound	GO:0071407	87	0.046
biomineral tissue development	GO:0031214	64	0.045
purine containing compound metabolic process	GO:0072521	311	0.045
regulation of transcription from rna polymerase ii promoter in response to hypoxia	GO:0061418	2	0.045
neuron maturation	GO:0042551	29	0.045
aromatic compound catabolic process	GO:0019439	286	0.044
dna repair	GO:0006281	107	0.044
histone deacetylation	GO:0016575	26	0.044
peptidyl lysine trimethylation	GO:0018023	12	0.044
response to nutrient levels	GO:0031667	109	0.044
glucose metabolic process	GO:0006006	92	0.044
purine nucleotide metabolic process	GO:0006163	302	0.044
regulation of myeloid cell differentiation	GO:0045637	96	0.044
regulation of gene expression by genetic imprinting	GO:0006349	15	0.044
regulation of lipid metabolic process	GO:0019216	118	0.044
negative regulation of histone methylation	GO:0031061	10	0.044
protein catabolic process	GO:0030163	221	0.043
rna processing	GO:0006396	105	0.042
regulation of cellular catabolic process	GO:0031329	242	0.042
nuclear transport	GO:0051169	139	0.042
cellularization	GO:0007349	1	0.042
muscle cell differentiation	GO:0042692	261	0.042
nephron development	GO:0072006	109	0.042
regulation of osteoclast differentiation	GO:0045670	36	0.042
pole plasm assembly	GO:0007315	2	0.042
negative regulation of cellular component organization	GO:0051129	194	0.042
regulation of dna binding	GO:0051101	39	0.041
rhombomere morphogenesis	GO:0021593	2	0.041
regulation of canonical wnt signaling pathway	GO:0060828	82	0.041
carbon catabolite activation of transcription	GO:0045991	4	0.041
negative regulation of wnt signaling pathway	GO:0030178	73	0.041
rig i signaling pathway	GO:0039529	4	0.041
regulation of response to dna damage stimulus	GO:2001020	34	0.041
monosaccharide metabolic process	GO:0005996	106	0.041
regulation of cellular ketone metabolic process	GO:0010565	66	0.040
endoderm formation	GO:0001706	20	0.040
chromatin remodeling	GO:0006338	32	0.040
blood vessel morphogenesis	GO:0048514	285	0.040
skeletal muscle organ development	GO:0060538	163	0.040	Mouse
mesenchymal cell proliferation	GO:0010463	44	0.040
regulation of carbohydrate metabolic process	GO:0006109	75	0.040
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	8	0.040
regulation of ossification	GO:0030278	112	0.040
positive regulation of programmed cell death	GO:0043068	218	0.040
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	1	0.040
cellular response to starvation	GO:0009267	57	0.040
regulation of stem cell maintenance	GO:2000036	17	0.040
syncytium formation by plasma membrane fusion	GO:0000768	42	0.039
antibacterial peptide production	GO:0002778	2	0.039
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis	GO:2000148	1	0.039
eye photoreceptor cell differentiation	GO:0001754	41	0.039
cellular response to acid chemical	GO:0071229	68	0.039
circadian behavior	GO:0048512	13	0.039
microtubule cytoskeleton organization	GO:0000226	157	0.038
striated muscle tissue development	GO:0014706	293	0.038	Mouse
intrahepatic bile duct development	GO:0035622	2	0.038
cellular amine metabolic process	GO:0044106	44	0.038
embryonic hemopoiesis	GO:0035162	23	0.038
cellular response to external stimulus	GO:0071496	88	0.038
response to alcohol	GO:0097305	48	0.037
regulation of cellular component biogenesis	GO:0044087	181	0.037
body morphogenesis	GO:0010171	45	0.037
smooth muscle tissue development	GO:0048745	22	0.037
regulation of kinase activity	GO:0043549	249	0.037
cellular response to abiotic stimulus	GO:0071214	56	0.037
regulation of schwann cell proliferation	GO:0010624	2	0.037
chromatin assembly	GO:0031497	13	0.037
face morphogenesis	GO:0060325	29	0.037
positive regulation of stem cell proliferation	GO:2000648	59	0.036
negative regulation of cell growth involved in cardiac muscle cell development	GO:0061052	2	0.036
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.036
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.036
spleen development	GO:0048536	39	0.036
peptidyl tyrosine modification	GO:0018212	145	0.036
bone development	GO:0060348	120	0.036
epithelial cell proliferation	GO:0050673	174	0.036
cellular response to alcohol	GO:0097306	23	0.036
pigment biosynthetic process	GO:0046148	26	0.035
response to decreased oxygen levels	GO:0036293	59	0.035
histone deubiquitination	GO:0016578	2	0.035
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.035
fat cell differentiation	GO:0045444	160	0.035
dna damage checkpoint	GO:0000077	26	0.035
organophosphate biosynthetic process	GO:0090407	122	0.035
regulation of morphogenesis of a branching structure	GO:0060688	53	0.035
response to oxygen levels	GO:0070482	62	0.035
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.035
regulation of histone deacetylation	GO:0031063	12	0.035
sister chromatid cohesion	GO:0007062	12	0.034
chromatin assembly or disassembly	GO:0006333	16	0.034
dendritic cell proliferation	GO:0044565	2	0.034
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.034
lung cell differentiation	GO:0060479	30	0.034
positive regulation of mitotic sister chromatid separation	GO:1901970	2	0.034
neuron projection guidance	GO:0097485	141	0.034
formation of radial glial scaffolds	GO:0021943	4	0.034
regulation of hormone secretion	GO:0046883	88	0.034
t helper cell differentiation	GO:0042093	28	0.034
cellular response to peptide	GO:1901653	92	0.033
neuronal stem cell maintenance	GO:0097150	17	0.033
regulation of cell cycle g2 m phase transition	GO:1902749	10	0.033
camp biosynthetic process	GO:0006171	31	0.033
cytoplasmic mrna processing body assembly	GO:0033962	6	0.033
neural precursor cell proliferation	GO:0061351	121	0.033
negative regulation of protein phosphorylation	GO:0001933	126	0.033
positive regulation of apoptotic process	GO:0043065	217	0.033
response to acid chemical	GO:0001101	111	0.033
posttranscriptional gene silencing	GO:0016441	10	0.033
embryonic eye morphogenesis	GO:0048048	29	0.033
mesodermal cell differentiation	GO:0048333	22	0.033
endocrine system development	GO:0035270	98	0.032
response to monosaccharide	GO:0034284	67	0.032
regulation of cellular response to stress	GO:0080135	159	0.032
establishment or maintenance of cell polarity	GO:0007163	86	0.032
negative regulation of intracellular protein transport	GO:0090317	27	0.032
lens development in camera type eye	GO:0002088	62	0.032
regulation of posttranscriptional gene silencing	GO:0060147	5	0.032
response to insulin	GO:0032868	100	0.032
response to oxidative stress	GO:0006979	123	0.031
molting cycle	GO:0042303	90	0.031	Worm
cellular response to nitric oxide	GO:0071732	4	0.031
regulation of activin receptor signaling pathway	GO:0032925	10	0.031
regulation of antibacterial peptide production	GO:0002786	1	0.031
cyclic purine nucleotide metabolic process	GO:0052652	43	0.031
embryonic viscerocranium morphogenesis	GO:0048703	8	0.031
regulation of cell motility	GO:2000145	236	0.031
cytoplasmic pattern recognition receptor signaling pathway in response to virus	GO:0039528	4	0.030
negative regulation of leukocyte proliferation	GO:0070664	46	0.030
neural tube patterning	GO:0021532	43	0.030
endoderm development	GO:0007492	45	0.030
immune effector process	GO:0002252	321	0.030
oxidation reduction process	GO:0055114	342	0.030
regulation of mapk cascade	GO:0043408	248	0.030
trachea development	GO:0060438	18	0.030
response to uv	GO:0009411	44	0.030
positive regulation of secretion	GO:0051047	130	0.030
gastrulation with mouth forming second	GO:0001702	29	0.030
embryonic limb morphogenesis	GO:0030326	126	0.030
purine nucleotide biosynthetic process	GO:0006164	65	0.029
embryonic digestive tract development	GO:0048566	27	0.029
negative regulation of mammary gland epithelial cell proliferation	GO:0033600	3	0.029
positive regulation of antimicrobial humoral response	GO:0002760	2	0.029
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.029
embryonic appendage morphogenesis	GO:0035113	126	0.029
collecting duct development	GO:0072044	11	0.029
head morphogenesis	GO:0060323	34	0.029
cardiac right atrium morphogenesis	GO:0003213	3	0.029
second messenger mediated signaling	GO:0019932	73	0.029
regulation of clathrin mediated endocytosis	GO:2000369	4	0.029
positive regulation of lipid metabolic process	GO:0045834	40	0.029
protein localization to membrane	GO:0072657	108	0.029
cellular response to radiation	GO:0071478	28	0.029
regulation of secretion	GO:0051046	274	0.029
tube closure	GO:0060606	91	0.028
regulation of hormone levels	GO:0010817	211	0.028
cell adhesion	GO:0007155	329	0.028
neuromuscular process	GO:0050905	99	0.028
monocarboxylic acid metabolic process	GO:0032787	191	0.028

Crebbp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.230
organ system cancer	DOID:0050686	0.130
cancer	DOID:162	0.130
nervous system disease	DOID:863	0.033
disease of anatomical entity	DOID:7	0.033

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