IMP: Integrative Multi-species Prediction

Mus musculus

27 known processes

Crkl

v-crk sarcoma virus CT10 oncogene homolog (avian)-like

(Aliases: 1110025F07Rik,AA589403,Crkol,AI325100)

Entrez: 12929
Ensembl: ENSMUSG00000006134
UniProtKB: A2RS58
UniProtKB: P47941

Process Predictions
Disease Predictions

Crkl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of clathrin mediated endocytosis	GO:2000369	4	0.722
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.690
regulation of cellular ketone metabolic process	GO:0010565	66	0.669
regulation of cellular amino acid metabolic process	GO:0006521	5	0.548
regulation of cellular amine metabolic process	GO:0033238	20	0.533
cellular amino acid metabolic process	GO:0006520	103	0.515
amine metabolic process	GO:0009308	45	0.504
myeloid cell differentiation	GO:0030099	233	0.427
regulation of hydrolase activity	GO:0051336	246	0.405
positive regulation of nervous system development	GO:0051962	221	0.401
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.396
leukocyte proliferation	GO:0070661	172	0.386
mapk cascade	GO:0000165	281	0.365	Fly
cell adhesion	GO:0007155	329	0.362
single organism cell adhesion	GO:0098602	156	0.325
cellular ketone metabolic process	GO:0042180	84	0.322
synaptic transmission	GO:0007268	329	0.321
regulation of protein kinase activity	GO:0045859	232	0.317
regulation of lymphocyte activation	GO:0051249	240	0.310
protein processing	GO:0016485	163	0.284
positive regulation of protein phosphorylation	GO:0001934	242	0.279
positive regulation of dna templated transcription elongation	GO:0032786	2	0.275
leukocyte differentiation	GO:0002521	342	0.274
regulation of cell activation	GO:0050865	289	0.272
cellular amine metabolic process	GO:0044106	44	0.270
t cell activation	GO:0042110	289	0.267
canonical wnt signaling pathway	GO:0060070	130	0.264
regulation of proteolysis	GO:0030162	164	0.259
endocytosis	GO:0006897	168	0.259	Worm Fly
rho protein signal transduction	GO:0007266	32	0.256
ras protein signal transduction	GO:0007265	77	0.256
regulation of kinase activity	GO:0043549	249	0.253
lymphocyte proliferation	GO:0046651	164	0.247
regionalization	GO:0003002	337	0.241
regulation of protein tyrosine kinase activity	GO:0061097	17	0.241
clathrin coat assembly	GO:0048268	2	0.231
cellular lipid metabolic process	GO:0044255	323	0.230
positive regulation of protein modification process	GO:0031401	299	0.225
regulation of protein serine threonine kinase activity	GO:0071900	157	0.215
positive regulation of programmed cell death	GO:0043068	218	0.214
forebrain development	GO:0030900	302	0.209
negative regulation of molecular function	GO:0044092	258	0.204
negative regulation of cellular protein metabolic process	GO:0032269	247	0.201
macromolecule catabolic process	GO:0009057	281	0.194
dna metabolic process	GO:0006259	303	0.193
regulation of transferase activity	GO:0051338	263	0.190
response to molecule of bacterial origin	GO:0002237	143	0.185
t cell proliferation	GO:0042098	120	0.185
regulation of t cell activation	GO:0050863	170	0.184
negative regulation of cell proliferation	GO:0008285	296	0.183
regulation of vesicle mediated transport	GO:0060627	139	0.181
wnt signaling pathway	GO:0016055	188	0.180
response to growth factor	GO:0070848	198	0.180
regulation of cellular response to stress	GO:0080135	159	0.177	Fly
negative regulation of cellular amine metabolic process	GO:0033239	1	0.177
immune effector process	GO:0002252	321	0.176
positive regulation of cellular amine metabolic process	GO:0033240	5	0.163
lipid biosynthetic process	GO:0008610	179	0.163
regulation of map kinase activity	GO:0043405	120	0.162
cell substrate adhesion	GO:0031589	130	0.161
negative regulation of phosphorylation	GO:0042326	166	0.159
regulation of ras protein signal transduction	GO:0046578	114	0.156
small gtpase mediated signal transduction	GO:0007264	97	0.154
leukocyte activation involved in immune response	GO:0002366	126	0.153
layer formation in cerebral cortex	GO:0021819	13	0.153
regulation of cellular component biogenesis	GO:0044087	181	0.150
positive regulation of apoptotic process	GO:0043065	217	0.148
positive regulation of creb transcription factor activity	GO:0032793	4	0.147
regulation of cell projection organization	GO:0031344	206	0.146
organophosphate catabolic process	GO:0046434	232	0.146
regulation of canonical wnt signaling pathway	GO:0060828	82	0.145
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.145
pallium development	GO:0021543	120	0.145
nucleoside triphosphate metabolic process	GO:0009141	230	0.145
cytokine production	GO:0001816	319	0.145
epidermal growth factor receptor signaling pathway	GO:0007173	28	0.143
regulation of rho protein signal transduction	GO:0035023	71	0.142
apoptotic signaling pathway	GO:0097190	306	0.140
regulation of neuron differentiation	GO:0045664	281	0.140
negative regulation of ras protein signal transduction	GO:0046580	18	0.139
cellularization	GO:0007349	1	0.138
t cell differentiation	GO:0030217	174	0.137
phospholipid metabolic process	GO:0006644	87	0.136
protein maturation	GO:0051604	176	0.135
regulation of leukocyte proliferation	GO:0070663	121	0.133
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.133
regulation of defense response	GO:0031347	233	0.133
cation homeostasis	GO:0055080	212	0.133
positive regulation of cell development	GO:0010720	237	0.133
platelet derived growth factor receptor signaling pathway	GO:0048008	32	0.133
divalent inorganic cation homeostasis	GO:0072507	138	0.132
cerebral cortex cell migration	GO:0021795	44	0.128
negative regulation of phosphate metabolic process	GO:0045936	184	0.126
peptidyl amino acid modification	GO:0018193	336	0.125
protein modification by small protein conjugation	GO:0032446	187	0.125
negative regulation of phosphorus metabolic process	GO:0010563	184	0.125
positive regulation of stress activated mapk cascade	GO:0032874	48	0.124	Fly
positive regulation of cytokine production	GO:0001819	174	0.124
positive regulation of transferase activity	GO:0051347	167	0.123
positive regulation of cell cycle	GO:0045787	92	0.123
regulation of cell migration	GO:0030334	219	0.122
leukocyte mediated immunity	GO:0002443	174	0.121
cellular response to lipid	GO:0071396	145	0.121
cytoplasmic transport	GO:0016482	234	0.119
anatomical structure homeostasis	GO:0060249	145	0.118
developmental maturation	GO:0021700	193	0.116
peptidyl tyrosine phosphorylation	GO:0018108	143	0.115
response to lipopolysaccharide	GO:0032496	128	0.114
regulation of cell cycle	GO:0051726	281	0.114
skeletal system development	GO:0001501	356	0.113
positive regulation of jnk cascade	GO:0046330	46	0.113	Fly
cellular response to cytokine stimulus	GO:0071345	189	0.113
regulation of cytokine production	GO:0001817	266	0.112
myeloid leukocyte differentiation	GO:0002573	119	0.111
protein secretion	GO:0009306	111	0.111
glutamate receptor signaling pathway	GO:0007215	35	0.110
axonogenesis	GO:0007409	274	0.110
regulation of apoptotic signaling pathway	GO:2001233	197	0.110
erbb signaling pathway	GO:0038127	32	0.110
regulation of cellular catabolic process	GO:0031329	242	0.108
radial glia guided migration of purkinje cell	GO:0021942	6	0.108
actin cytoskeleton organization	GO:0030036	220	0.107	Mouse Worm
cell activation involved in immune response	GO:0002263	126	0.106
morphogenesis of a branching structure	GO:0001763	203	0.106
protein localization to organelle	GO:0033365	185	0.105
positive regulation of neuron differentiation	GO:0045666	141	0.105
regulation of mapk cascade	GO:0043408	248	0.105	Fly
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.105
negative regulation of intracellular signal transduction	GO:1902532	167	0.104
negative regulation of hydrolase activity	GO:0051346	71	0.104
metal ion homeostasis	GO:0055065	189	0.102
hematopoietic progenitor cell differentiation	GO:0002244	143	0.102
extrinsic apoptotic signaling pathway	GO:0097191	126	0.101
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.101
guanosine containing compound metabolic process	GO:1901068	144	0.100
positive regulation of kinase activity	GO:0033674	155	0.099
blood vessel morphogenesis	GO:0048514	285	0.099
adaptive immune response	GO:0002250	155	0.098
sensory perception	GO:0007600	245	0.098
spermatogenesis	GO:0007283	284	0.097
mitotic cell cycle	GO:0000278	195	0.097
regulation of ion transport	GO:0043269	215	0.097
cellular response to dna damage stimulus	GO:0006974	207	0.097
germ cell development	GO:0007281	185	0.096	Fly
negative regulation of protein metabolic process	GO:0051248	282	0.096
regulation of receptor activity	GO:0010469	41	0.096
organonitrogen compound catabolic process	GO:1901565	264	0.095
negative regulation of immune system process	GO:0002683	209	0.095
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.094
cerebral cortex radially oriented cell migration	GO:0021799	31	0.094
stress activated mapk cascade	GO:0051403	80	0.094	Fly
alpha beta t cell activation	GO:0046631	91	0.093
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	13	0.093
activation of jun kinase activity	GO:0007257	15	0.093
response to organonitrogen compound	GO:0010243	246	0.092
regulation of innate immune response	GO:0045088	91	0.091
regulation of protein maturation	GO:1903317	96	0.091
purine nucleotide catabolic process	GO:0006195	211	0.090
cellular response to organonitrogen compound	GO:0071417	145	0.089
cerebral cortex development	GO:0021987	86	0.089
protein localization to nucleus	GO:0034504	121	0.088
activation of immune response	GO:0002253	138	0.087
telencephalon cell migration	GO:0022029	55	0.087
substrate adhesion dependent cell spreading	GO:0034446	30	0.087
cellular response to hormone stimulus	GO:0032870	150	0.087
male gamete generation	GO:0048232	285	0.086
cell aging	GO:0007569	35	0.085
regulation of leukocyte differentiation	GO:1902105	159	0.084
lymphocyte differentiation	GO:0030098	242	0.084
regulation of membrane potential	GO:0042391	192	0.084
angiogenesis	GO:0001525	201	0.083
regulation of establishment of protein localization	GO:0070201	181	0.083
phagocytosis	GO:0006909	66	0.082	Worm Fly
positive regulation of proteolysis	GO:0045862	85	0.082
guanosine containing compound catabolic process	GO:1901069	144	0.082
regulation of t cell proliferation	GO:0042129	92	0.082
regulation of purine nucleotide metabolic process	GO:1900542	169	0.082
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.081
protein import	GO:0017038	101	0.081
positive regulation of jun kinase activity	GO:0043507	30	0.081
positive regulation of dendritic spine morphogenesis	GO:0061003	8	0.081
telencephalon development	GO:0021537	186	0.080
body morphogenesis	GO:0010171	45	0.080
positive regulation of defense response	GO:0031349	124	0.080
alcohol metabolic process	GO:0006066	116	0.080
synapse organization	GO:0050808	125	0.080
response to oxidative stress	GO:0006979	123	0.080
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.079
positive regulation of map kinase activity	GO:0043406	84	0.078
regulation of organelle organization	GO:0033043	289	0.078	Mouse
immune response regulating signaling pathway	GO:0002764	125	0.078
forebrain cell migration	GO:0021885	58	0.078
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	6	0.077
positive regulation of cell motility	GO:2000147	116	0.077
regulation of ras gtpase activity	GO:0032318	88	0.077
epithelial tube morphogenesis	GO:0060562	303	0.077
glycerolipid metabolic process	GO:0046486	122	0.076
positive regulation of neuron projection development	GO:0010976	79	0.076
multicellular organismal homeostasis	GO:0048871	164	0.076
regulation of protein processing	GO:0070613	96	0.076
regulation of synaptic plasticity	GO:0048167	87	0.075
actin filament organization	GO:0007015	113	0.075
negative regulation of proteolysis	GO:0045861	74	0.075
response to peptide	GO:1901652	136	0.075
neuron projection guidance	GO:0097485	141	0.074
cytokine mediated signaling pathway	GO:0019221	115	0.073
regulation of peptidase activity	GO:0052547	96	0.073
regulation of neuron projection development	GO:0010975	169	0.073
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.073
positive regulation of cell migration	GO:0030335	109	0.072
positive regulation of rac gtpase activity	GO:0032855	14	0.072
positive regulation of mapk cascade	GO:0043410	170	0.072	Fly
embryonic placenta development	GO:0001892	98	0.072
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.071
single organismal cell cell adhesion	GO:0016337	131	0.071
lymphocyte mediated immunity	GO:0002449	139	0.071
transmembrane transport	GO:0055085	412	0.069
regulation of leukocyte mediated immunity	GO:0002703	104	0.069
branching morphogenesis of an epithelial tube	GO:0048754	159	0.069
positive regulation of protein kinase activity	GO:0045860	144	0.068
peptidyl tyrosine modification	GO:0018212	145	0.068
regulation of gtp catabolic process	GO:0033124	113	0.067
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.067
protein ubiquitination	GO:0016567	171	0.067
cellular nitrogen compound catabolic process	GO:0044270	280	0.067
gland development	GO:0048732	330	0.067
cellular response to growth factor stimulus	GO:0071363	197	0.067
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.066
regulation of secretion by cell	GO:1903530	249	0.066
morphogenesis of embryonic epithelium	GO:0016331	159	0.066
cellular response to biotic stimulus	GO:0071216	92	0.066
regulation of nucleotide catabolic process	GO:0030811	122	0.066
homeostasis of number of cells	GO:0048872	210	0.066
glycerolipid biosynthetic process	GO:0045017	50	0.065
positive regulation of hydrolase activity	GO:0051345	148	0.065
neuron migration	GO:0001764	122	0.065
regulation of jnk cascade	GO:0046328	62	0.065	Fly
negative regulation of kinase activity	GO:0033673	81	0.064
intracellular protein transport	GO:0006886	204	0.064
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.064
camera type eye development	GO:0043010	266	0.064
placenta development	GO:0001890	140	0.064
nucleoside phosphate catabolic process	GO:1901292	222	0.064
axon guidance	GO:0007411	141	0.064
response to acid chemical	GO:0001101	111	0.064
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.064
positive regulation of t cell anergy	GO:0002669	4	0.064
protein modification by small protein conjugation or removal	GO:0070647	207	0.063
regulation of jun kinase activity	GO:0043506	40	0.063
neural tube formation	GO:0001841	108	0.063
organelle localization	GO:0051640	179	0.063
g1 s transition of mitotic cell cycle	GO:0000082	57	0.063
cellular ion homeostasis	GO:0006873	165	0.063
photoreceptor cell differentiation	GO:0046530	52	0.063
stem cell differentiation	GO:0048863	268	0.063
regulation of stress activated mapk cascade	GO:0032872	69	0.062	Fly
neural tube closure	GO:0001843	90	0.062
erk1 and erk2 cascade	GO:0070371	77	0.062
glycerophospholipid metabolic process	GO:0006650	71	0.062
organic hydroxy compound metabolic process	GO:1901615	203	0.062
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.061
regulation of rho gtpase activity	GO:0032319	58	0.061
response to organic cyclic compound	GO:0014070	198	0.061
protein catabolic process	GO:0030163	221	0.061
t cell anergy	GO:0002870	4	0.061
purine ribonucleotide catabolic process	GO:0009154	208	0.061
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.061
cellular protein catabolic process	GO:0044257	155	0.061
establishment of protein localization to organelle	GO:0072594	118	0.060
regulation of glutamate receptor signaling pathway	GO:1900449	16	0.060
sterol metabolic process	GO:0016125	58	0.060
cellular homeostasis	GO:0019725	240	0.060
regulation of transmembrane transport	GO:0034762	128	0.059
gastrulation	GO:0007369	116	0.059
mitotic cell cycle process	GO:1903047	159	0.059
cellular protein complex assembly	GO:0043623	116	0.059
regulation of purine nucleotide catabolic process	GO:0033121	122	0.058
cation transport	GO:0006812	399	0.057
stress activated protein kinase signaling cascade	GO:0031098	81	0.057	Fly
sequestering of metal ion	GO:0051238	19	0.056
lymphocyte homeostasis	GO:0002260	64	0.056
regulation of body fluid levels	GO:0050878	162	0.056
regulation of endocytosis	GO:0030100	69	0.056
nucleoside phosphate metabolic process	GO:0006753	338	0.056
positive regulation of cell activation	GO:0050867	158	0.056
myeloid leukocyte activation	GO:0002274	83	0.056
immune response activating signal transduction	GO:0002757	116	0.056
regulation of endopeptidase activity	GO:0052548	89	0.056
positive regulation of cell death	GO:0010942	224	0.055
embryonic organ morphogenesis	GO:0048562	276	0.055
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.055
negative regulation of wnt signaling pathway	GO:0030178	73	0.055
cell fate commitment	GO:0045165	210	0.055
immunoglobulin mediated immune response	GO:0016064	69	0.054
regulation of protein transport	GO:0051223	163	0.054
multicellular organism growth	GO:0035264	161	0.054
phosphatidylinositol metabolic process	GO:0046488	45	0.054
regulation of ion transmembrane transporter activity	GO:0032412	54	0.054
cell cycle g1 s phase transition	GO:0044843	57	0.053
regulation of hormone levels	GO:0010817	211	0.053
negative regulation of canonical wnt signaling pathway	GO:0090090	51	0.053
neural tube development	GO:0021915	160	0.053
steroid metabolic process	GO:0008202	119	0.053
triglyceride biosynthetic process	GO:0019432	17	0.053
regulation of stem cell differentiation	GO:2000736	50	0.053
regulation of epithelial cell proliferation	GO:0050678	141	0.053
modification dependent macromolecule catabolic process	GO:0043632	133	0.053
negative regulation of protein modification process	GO:0031400	163	0.052
regulation of integrin mediated signaling pathway	GO:2001044	8	0.052
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.052
muscle tissue development	GO:0060537	308	0.052
membrane organization	GO:0061024	245	0.051	Worm Fly
regulation of lymphocyte proliferation	GO:0050670	117	0.051
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.051
positive regulation of cell projection organization	GO:0031346	95	0.051
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.051
sensory organ morphogenesis	GO:0090596	242	0.050
cellular component assembly involved in morphogenesis	GO:0010927	139	0.050
divalent inorganic cation transport	GO:0072511	178	0.050
innate immune response	GO:0045087	157	0.050
endodermal cell fate specification	GO:0001714	4	0.050
negative regulation of neuron apoptotic process	GO:0043524	92	0.050
stem cell development	GO:0048864	219	0.049
purine ribonucleoside metabolic process	GO:0046128	241	0.049
negative regulation of erbb signaling pathway	GO:1901185	7	0.049
endomembrane system organization	GO:0010256	147	0.049
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.049
digestive system development	GO:0055123	200	0.049
positive regulation of clathrin mediated endocytosis	GO:2000370	1	0.049
gtp catabolic process	GO:0006184	143	0.049
endocrine system development	GO:0035270	98	0.049
calcium ion homeostasis	GO:0055074	127	0.049
glycosyl compound metabolic process	GO:1901657	246	0.049
muscle cell differentiation	GO:0042692	261	0.048	Zebrafish
wound healing	GO:0042060	157	0.048
ribose phosphate metabolic process	GO:0019693	291	0.048
purine ribonucleotide metabolic process	GO:0009150	290	0.048
lymphocyte anergy	GO:0002249	4	0.048
negative regulation of cell cycle	GO:0045786	123	0.048
ion transmembrane transport	GO:0034220	361	0.048
cellular response to lipopolysaccharide	GO:0071222	77	0.047
regulation of transporter activity	GO:0032409	57	0.047
negative regulation of hormone metabolic process	GO:0032351	4	0.047
regulation of cell adhesion	GO:0030155	154	0.047
positive regulation of secretion	GO:0051047	130	0.047
regulation of nucleoside metabolic process	GO:0009118	130	0.047
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.047
cellular response to oxidative stress	GO:0034599	76	0.047
myeloid cell homeostasis	GO:0002262	114	0.047
nucleotide metabolic process	GO:0009117	332	0.047
regulation of lymphocyte anergy	GO:0002911	4	0.046
reactive oxygen species metabolic process	GO:0072593	84	0.046
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.046
negative regulation of cell activation	GO:0050866	111	0.046
lymphocyte activation involved in immune response	GO:0002285	93	0.046
toll like receptor signaling pathway	GO:0002224	38	0.046
positive regulation of secretion by cell	GO:1903532	114	0.046
negative regulation of epidermal growth factor activated receptor activity	GO:0007175	3	0.045
regulation of epidermal growth factor activated receptor activity	GO:0007176	7	0.045
metencephalon development	GO:0022037	89	0.045
spinal cord development	GO:0021510	81	0.045
activation of rac gtpase activity	GO:0032863	2	0.045
golgi localization	GO:0051645	4	0.045
response to peptide hormone	GO:0043434	127	0.045
vesicle organization	GO:0016050	60	0.044
negative regulation of hormone biosynthetic process	GO:0032353	4	0.044
aromatic compound catabolic process	GO:0019439	286	0.044
ribonucleoside catabolic process	GO:0042454	206	0.044
inositol lipid mediated signaling	GO:0048017	41	0.044
purine nucleoside catabolic process	GO:0006152	205	0.043
carbohydrate metabolic process	GO:0005975	230	0.043
response to drug	GO:0042493	75	0.043
skeletal muscle organ development	GO:0060538	163	0.043
morphogenesis of a branching epithelium	GO:0061138	193	0.043
response to fibroblast growth factor	GO:0071774	47	0.043
regulation of protein binding	GO:0043393	60	0.043
phosphatidylinositol mediated signaling	GO:0048015	41	0.043
regulation of protein localization	GO:0032880	231	0.043
engulfment of apoptotic cell	GO:0043652	3	0.043	Worm
negative regulation of transferase activity	GO:0051348	85	0.042
cellular response to molecule of bacterial origin	GO:0071219	83	0.042
nitrogen compound transport	GO:0071705	271	0.042
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.042
t cell receptor signaling pathway	GO:0050852	46	0.042
vesicle coating	GO:0006901	2	0.042
regulation of t cell anergy	GO:0002667	4	0.042
acylglycerol metabolic process	GO:0006639	55	0.042
positive regulation of mitotic cell cycle	GO:0045931	41	0.041
organelle assembly	GO:0070925	177	0.041
regulation of wnt signaling pathway	GO:0030111	123	0.041
positive regulation of rho gtpase activity	GO:0032321	41	0.041
heart morphogenesis	GO:0003007	178	0.041
antigen receptor mediated signaling pathway	GO:0050851	64	0.041
regulation of phospholipid catabolic process	GO:0060696	2	0.041
b cell homeostasis	GO:0001782	34	0.041
primary neural tube formation	GO:0014020	95	0.040
heterocycle catabolic process	GO:0046700	280	0.040
rac protein signal transduction	GO:0016601	13	0.040
regulation of erbb signaling pathway	GO:1901184	16	0.040
cell type specific apoptotic process	GO:0097285	268	0.040
regulation of protein complex assembly	GO:0043254	83	0.040
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.039
organic cyclic compound catabolic process	GO:1901361	295	0.039
dna recombination	GO:0006310	92	0.039
sterol transmembrane transport	GO:0035382	2	0.039
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.039
nuclear transport	GO:0051169	139	0.039
endoderm development	GO:0007492	45	0.039
nucleoside catabolic process	GO:0009164	206	0.039
epithelial cell proliferation	GO:0050673	174	0.039
positive regulation of lymphocyte activation	GO:0051251	140	0.039
negative regulation of nervous system development	GO:0051961	156	0.038
negative regulation of protein maturation	GO:1903318	79	0.038
skeletal system morphogenesis	GO:0048705	203	0.038
regulation of muscle tissue development	GO:1901861	97	0.038
regulation of lipid metabolic process	GO:0019216	118	0.038
labyrinthine layer development	GO:0060711	49	0.038
regulation of cellular component size	GO:0032535	121	0.037
regulation of system process	GO:0044057	200	0.037
regulation of protein secretion	GO:0050708	82	0.037
regulation of t cell differentiation	GO:0045580	83	0.037
macrophage activation	GO:0042116	27	0.037
hormone metabolic process	GO:0042445	86	0.037
epithelial tube formation	GO:0072175	130	0.037
release of sequestered calcium ion into cytosol	GO:0051209	42	0.037
regulation of cell cycle process	GO:0010564	160	0.036
chemotaxis	GO:0006935	247	0.036
regulation of secretion	GO:0051046	274	0.036
regulation of erk1 and erk2 cascade	GO:0070372	71	0.036
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.036
ameboidal type cell migration	GO:0001667	128	0.036	Fly
positive regulation of adaptive immune response	GO:0002821	61	0.036
neuron death	GO:0070997	154	0.036
positive regulation of cell cycle process	GO:0090068	61	0.036
regulation of adaptive immune response	GO:0002819	90	0.036
midgut development	GO:0007494	4	0.036
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.036
positive regulation of immune effector process	GO:0002699	107	0.036
protein kinase b signaling	GO:0043491	74	0.035
protein targeting	GO:0006605	143	0.035
mitochondrion organization	GO:0007005	134	0.035
regulation of intracellular transport	GO:0032386	159	0.035
response to radiation	GO:0009314	165	0.035
regulation of lymphocyte differentiation	GO:0045619	107	0.035
rhythmic process	GO:0048511	174	0.035
maintenance of location	GO:0051235	89	0.035
activation of mapk activity	GO:0000187	59	0.035
positive regulation of cell adhesion	GO:0045785	80	0.035
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.035
regulation of nucleotide metabolic process	GO:0006140	169	0.035
blood circulation	GO:0008015	195	0.035
b cell differentiation	GO:0030183	78	0.035
negative regulation of mapk cascade	GO:0043409	65	0.035
posttranscriptional regulation of gene expression	GO:0010608	155	0.035
negative regulation of protein processing	GO:0010955	79	0.034
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.034
ribonucleoside metabolic process	GO:0009119	245	0.034
positive regulation of integrin mediated signaling pathway	GO:2001046	5	0.034
regulation of n methyl d aspartate selective glutamate receptor activity	GO:2000310	10	0.034
neuromuscular process	GO:0050905	99	0.034
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.034
positive regulation of nucleotide catabolic process	GO:0030813	88	0.034
lipid phosphorylation	GO:0046834	25	0.034
cellular calcium ion homeostasis	GO:0006874	119	0.033
ubiquitin dependent protein catabolic process	GO:0006511	129	0.033
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.033
jak stat cascade	GO:0007259	42	0.033
regulation of cell cycle phase transition	GO:1901987	77	0.033
digestive tract development	GO:0048565	190	0.033
histone methylation	GO:0016571	71	0.033
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.033
regulation of neuron death	GO:1901214	134	0.033
positive regulation of tor signaling	GO:0032008	3	0.033
transmission of nerve impulse	GO:0019226	76	0.033
negative regulation of erk1 and erk2 cascade	GO:0070373	21	0.033
hindbrain development	GO:0030902	128	0.032
regulation of binding	GO:0051098	111	0.032
b cell proliferation	GO:0042100	53	0.032
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.032
cellular chemical homeostasis	GO:0055082	215	0.032
ossification	GO:0001503	216	0.032
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.032
action potential	GO:0001508	78	0.032
regulation of ion transmembrane transport	GO:0034765	119	0.032
epithelial cell development	GO:0002064	159	0.032	Fly
regulation of inflammatory response	GO:0050727	147	0.032
dna repair	GO:0006281	107	0.032
neuron apoptotic process	GO:0051402	142	0.031
peptidyl serine modification	GO:0018209	83	0.031
chromatin organization	GO:0006325	206	0.031
cellular response to organic cyclic compound	GO:0071407	87	0.031
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.031
sequestering of calcium ion	GO:0051208	18	0.031

Crkl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.034
	nervous system disease	DOID:863	0	0.034

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