IMP: Integrative Multi-species Prediction

Mus musculus

104 known processes

Edn3

endothelin 3

(Aliases: 114-CH19,114CH19,ls,tmgc48)

Ensembl: ENSMUSG00000027524
Entrez: 13616
UniProtKB: P48299
UniProtKB: A2APU5

Process Predictions
Disease Predictions

Edn3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of neuron differentiation	GO:0045664	281	0.911
striated muscle tissue development	GO:0014706	293	0.828
regulation of neuron projection development	GO:0010975	169	0.768
purine containing compound metabolic process	GO:0072521	311	0.758	Mouse
locomotory behavior	GO:0007626	195	0.748
blood vessel morphogenesis	GO:0048514	285	0.744	Mouse
axonogenesis	GO:0007409	274	0.743
regulation of system process	GO:0044057	200	0.701	Human Mouse
central nervous system neuron differentiation	GO:0021953	162	0.679
muscle cell differentiation	GO:0042692	261	0.653
regulation of cellular amino acid metabolic process	GO:0006521	5	0.643
positive regulation of cell development	GO:0010720	237	0.623
regulation of cellular amine metabolic process	GO:0033238	20	0.620
gland development	GO:0048732	330	0.610
purine ribonucleotide metabolic process	GO:0009150	290	0.606	Mouse
cardiac muscle tissue development	GO:0048738	130	0.605
mesenchyme development	GO:0060485	152	0.588
neuron projection guidance	GO:0097485	141	0.585
telencephalon development	GO:0021537	186	0.569
urogenital system development	GO:0001655	261	0.534
cerebral cortex development	GO:0021987	86	0.532
cell division	GO:0051301	120	0.526	Human
ribose phosphate metabolic process	GO:0019693	291	0.522	Mouse
digestive tract development	GO:0048565	190	0.517
angiogenesis	GO:0001525	201	0.513	Mouse
regulation of ossification	GO:0030278	112	0.503
camera type eye development	GO:0043010	266	0.503
branching morphogenesis of an epithelial tube	GO:0048754	159	0.500	Mouse
heart morphogenesis	GO:0003007	178	0.479
adult locomotory behavior	GO:0008344	91	0.469
telencephalon cell migration	GO:0022029	55	0.462
positive regulation of protein phosphorylation	GO:0001934	242	0.457	Human
regionalization	GO:0003002	337	0.456	Mouse
epidermis development	GO:0008544	187	0.453
digestive system development	GO:0055123	200	0.452
negative regulation of cellular amine metabolic process	GO:0033239	1	0.446
negative regulation of neuron differentiation	GO:0045665	101	0.446
mesenchymal cell development	GO:0014031	93	0.437
cellular amino acid metabolic process	GO:0006520	103	0.437
spinal cord development	GO:0021510	81	0.427
skeletal system development	GO:0001501	356	0.427	Mouse
skin development	GO:0043588	220	0.425
pallium development	GO:0021543	120	0.417
regulation of cell motility	GO:2000145	236	0.413
organelle localization	GO:0051640	179	0.412
respiratory tube development	GO:0030323	167	0.412	Mouse
bronchiole development	GO:0060435	3	0.412
forebrain development	GO:0030900	302	0.409
cell differentiation in spinal cord	GO:0021515	53	0.406
limbic system development	GO:0021761	72	0.405
branching involved in salivary gland morphogenesis	GO:0060445	26	0.402
axon guidance	GO:0007411	141	0.401
glandular epithelial cell differentiation	GO:0002067	38	0.397
sensory organ morphogenesis	GO:0090596	242	0.392	Mouse
appendage development	GO:0048736	166	0.387
epithelial tube morphogenesis	GO:0060562	303	0.384	Mouse
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.379
mapk cascade	GO:0000165	281	0.373	Human
neuron migration	GO:0001764	122	0.372
regulation of cellular ketone metabolic process	GO:0010565	66	0.370
second messenger mediated signaling	GO:0019932	73	0.362	Human
cardiac chamber morphogenesis	GO:0003206	93	0.360
sensory perception	GO:0007600	245	0.357
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.348
regulation of cell division	GO:0051302	76	0.345	Human
cell maturation	GO:0048469	127	0.340
determination of left right symmetry	GO:0007368	80	0.340
embryonic appendage morphogenesis	GO:0035113	126	0.339
wnt signaling pathway	GO:0016055	188	0.338
organophosphate biosynthetic process	GO:0090407	122	0.337	Mouse
homeostasis of number of cells	GO:0048872	210	0.336
chemotaxis	GO:0006935	247	0.335	Human
lymphocyte differentiation	GO:0030098	242	0.334
regulation of cytokine production	GO:0001817	266	0.333
astrocyte fate commitment	GO:0060018	4	0.332
embryonic organ morphogenesis	GO:0048562	276	0.331	Mouse
purine nucleotide metabolic process	GO:0006163	302	0.329	Mouse
neuron projection extension	GO:1990138	64	0.326
developmental maturation	GO:0021700	193	0.324
muscle tissue development	GO:0060537	308	0.323
cellular amine metabolic process	GO:0044106	44	0.316
stem cell development	GO:0048864	219	0.315
ribonucleotide metabolic process	GO:0009259	291	0.313	Mouse
chondrocyte differentiation	GO:0002062	72	0.313
negative regulation of molecular function	GO:0044092	258	0.311
ribonucleoside catabolic process	GO:0042454	206	0.310
limb morphogenesis	GO:0035108	149	0.308
cardiac ventricle morphogenesis	GO:0003208	50	0.306
synaptic transmission	GO:0007268	329	0.306	Mouse
regulation of anatomical structure size	GO:0090066	178	0.305	Human
regulation of cell growth	GO:0001558	91	0.300
regulation of cell projection organization	GO:0031344	206	0.298
heart contraction	GO:0060047	93	0.297	Human
cell fate commitment	GO:0045165	210	0.290
canonical wnt signaling pathway	GO:0060070	130	0.289
cardiac muscle tissue morphogenesis	GO:0055008	44	0.289
positive regulation of growth	GO:0045927	104	0.288
action potential	GO:0001508	78	0.286
mesenchymal cell differentiation	GO:0048762	107	0.284
regulation of cell migration	GO:0030334	219	0.284
central nervous system neuron development	GO:0021954	67	0.280
respiratory system development	GO:0060541	190	0.280	Mouse
negative regulation of cellular component organization	GO:0051129	194	0.276
neural crest cell differentiation	GO:0014033	54	0.276
developmental cell growth	GO:0048588	84	0.275
leukocyte differentiation	GO:0002521	342	0.273
salivary gland morphogenesis	GO:0007435	33	0.272
spleen development	GO:0048536	39	0.272
cell adhesion	GO:0007155	329	0.272
morphogenesis of a branching epithelium	GO:0061138	193	0.270	Mouse
blood circulation	GO:0008015	195	0.268	Human Mouse
cognition	GO:0050890	149	0.266
sensory perception of pain	GO:0019233	47	0.265
nucleobase containing small molecule metabolic process	GO:0055086	352	0.263	Mouse
regulation of muscle system process	GO:0090257	80	0.263	Mouse
regulation of heart contraction	GO:0008016	77	0.261	Human
embryonic epithelial tube formation	GO:0001838	130	0.260
transmembrane transport	GO:0055085	412	0.256
limb development	GO:0060173	166	0.256
epithelial cell proliferation	GO:0050673	174	0.256
anatomical structure homeostasis	GO:0060249	145	0.254
establishment of organelle localization	GO:0051656	122	0.252
morphogenesis of embryonic epithelium	GO:0016331	159	0.251
cellular response to growth factor stimulus	GO:0071363	197	0.251
cellular chemical homeostasis	GO:0055082	215	0.248
amine metabolic process	GO:0009308	45	0.247
negative regulation of nervous system development	GO:0051961	156	0.246
epithelial cell development	GO:0002064	159	0.242
cytokine production	GO:0001816	319	0.241
stem cell differentiation	GO:0048863	268	0.241
glial cell development	GO:0021782	54	0.241
exocrine system development	GO:0035272	45	0.241
positive regulation of neuron differentiation	GO:0045666	141	0.237
regulation of organ morphogenesis	GO:2000027	144	0.236
negative regulation of phosphorus metabolic process	GO:0010563	184	0.236	Mouse
cation transmembrane transport	GO:0098655	266	0.234
gonad development	GO:0008406	141	0.230
purine containing compound biosynthetic process	GO:0072522	70	0.227	Mouse
cell type specific apoptotic process	GO:0097285	268	0.225
nephron tubule development	GO:0072080	84	0.221
regulation of protein transport	GO:0051223	163	0.217
peptidyl amino acid modification	GO:0018193	336	0.217
positive regulation of neuron projection development	GO:0010976	79	0.216
cellular homeostasis	GO:0019725	240	0.215
nuclear division	GO:0000280	158	0.214	Human
multicellular organismal signaling	GO:0035637	91	0.213
endocrine system development	GO:0035270	98	0.211
fat cell differentiation	GO:0045444	160	0.211
small gtpase mediated signal transduction	GO:0007264	97	0.211
tube formation	GO:0035148	140	0.210
lung development	GO:0030324	164	0.210	Mouse
cellular ketone metabolic process	GO:0042180	84	0.210
purine nucleotide catabolic process	GO:0006195	211	0.209
negative regulation of phosphate metabolic process	GO:0045936	184	0.206	Mouse
nucleoside catabolic process	GO:0009164	206	0.206
regulation of homeostatic process	GO:0032844	182	0.202	Mouse
adult behavior	GO:0030534	135	0.202
regulation of osteoblast differentiation	GO:0045667	67	0.200
myeloid cell homeostasis	GO:0002262	114	0.199
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.198
meiotic cell cycle	GO:0051321	122	0.197
purine ribonucleotide catabolic process	GO:0009154	208	0.197
single organism cell adhesion	GO:0098602	156	0.196
cell growth	GO:0016049	130	0.196
pancreas development	GO:0031016	57	0.193
inorganic cation transmembrane transport	GO:0098662	207	0.191
ossification	GO:0001503	216	0.190
ras protein signal transduction	GO:0007265	77	0.189
kidney morphogenesis	GO:0060993	83	0.189
neural tube formation	GO:0001841	108	0.188
synapse organization	GO:0050808	125	0.187
neural crest cell migration	GO:0001755	32	0.185
columnar cuboidal epithelial cell development	GO:0002066	29	0.184
embryonic limb morphogenesis	GO:0030326	126	0.183
nucleotide metabolic process	GO:0009117	332	0.183	Mouse
muscle adaptation	GO:0043500	39	0.182
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.182
t cell differentiation	GO:0030217	174	0.181
neuromuscular process	GO:0050905	99	0.181
forebrain generation of neurons	GO:0021872	63	0.180
regulation of vasculature development	GO:1901342	88	0.179
t cell activation	GO:0042110	289	0.179
regulation of epithelial cell proliferation	GO:0050678	141	0.177
regulation of membrane potential	GO:0042391	192	0.175
lung secretory cell differentiation	GO:0061140	13	0.174
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.172
germ cell development	GO:0007281	185	0.172
regulation of blood circulation	GO:1903522	93	0.171	Human
purine ribonucleoside metabolic process	GO:0046128	241	0.170
cardiac ventricle development	GO:0003231	83	0.169
ameboidal type cell migration	GO:0001667	128	0.169
muscle tissue morphogenesis	GO:0060415	53	0.169
epithelial tube formation	GO:0072175	130	0.168
salivary gland development	GO:0007431	37	0.168
regulation of purine nucleotide metabolic process	GO:1900542	169	0.168	Mouse
hindbrain development	GO:0030902	128	0.166
multi organism behavior	GO:0051705	62	0.166
multicellular organism growth	GO:0035264	161	0.165
dendrite development	GO:0016358	115	0.163
mitotic cell cycle process	GO:1903047	159	0.163	Human
myeloid cell differentiation	GO:0030099	233	0.163
positive regulation of cellular amine metabolic process	GO:0033240	5	0.162
positive regulation of nervous system development	GO:0051962	221	0.162
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.161
single organismal cell cell adhesion	GO:0016337	131	0.160
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.159
artery development	GO:0060840	53	0.158
gliogenesis	GO:0042063	141	0.158
regulation of cardiac muscle tissue growth	GO:0055021	26	0.157
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.157
glial cell differentiation	GO:0010001	131	0.156
bone development	GO:0060348	120	0.156
regulation of ion transmembrane transport	GO:0034765	119	0.155
primary neural tube formation	GO:0014020	95	0.155
regulation of cardiac muscle tissue development	GO:0055024	31	0.154
digestive tract morphogenesis	GO:0048546	147	0.154
positive regulation of voltage gated calcium channel activity	GO:1901387	2	0.151
organonitrogen compound biosynthetic process	GO:1901566	192	0.151	Mouse
cardiac chamber development	GO:0003205	108	0.150
male sex differentiation	GO:0046661	109	0.150
cell fate specification	GO:0001708	72	0.149
regulation of canonical wnt signaling pathway	GO:0060828	82	0.149
negative regulation of cell proliferation	GO:0008285	296	0.148
neuronal action potential	GO:0019228	54	0.147
hair follicle morphogenesis	GO:0031069	29	0.146
muscle cell development	GO:0055001	133	0.144
bmp signaling pathway	GO:0030509	93	0.143
negative regulation of neuron projection development	GO:0010977	50	0.143
mammary gland specification	GO:0060594	4	0.143
regulation of leukocyte differentiation	GO:1902105	159	0.142
purine ribonucleoside catabolic process	GO:0046130	205	0.142
glycosyl compound metabolic process	GO:1901657	246	0.142
embryonic heart tube morphogenesis	GO:0003143	51	0.141
circulatory system process	GO:0003013	197	0.141	Human Mouse
regulation of mitotic cell cycle	GO:0007346	126	0.141	Human
forebrain neuron development	GO:0021884	30	0.140
gastrulation	GO:0007369	116	0.140
cartilage development	GO:0051216	140	0.140	Mouse
circadian rhythm	GO:0007623	114	0.139
feeding behavior	GO:0007631	62	0.139
muscle contraction	GO:0006936	101	0.139	Human Mouse
lung epithelial cell differentiation	GO:0060487	29	0.139
regulation of axon extension	GO:0030516	43	0.138
forebrain cell migration	GO:0021885	58	0.137
multicellular organismal homeostasis	GO:0048871	164	0.135	Mouse
regulation of heart rate	GO:0002027	36	0.135	Human
muscle system process	GO:0003012	141	0.135	Human Mouse
lung alveolus development	GO:0048286	45	0.134	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.134	Mouse
tissue remodeling	GO:0048771	102	0.133
positive regulation of nucleotide catabolic process	GO:0030813	88	0.132
negative regulation of immune system process	GO:0002683	209	0.132
cellular nitrogen compound catabolic process	GO:0044270	280	0.132
male gamete generation	GO:0048232	285	0.131
embryonic digestive tract development	GO:0048566	27	0.131
lung morphogenesis	GO:0060425	50	0.131
endodermal cell fate specification	GO:0001714	4	0.130
regulation of chemotaxis	GO:0050920	53	0.130	Human
ribonucleotide catabolic process	GO:0009261	208	0.129
carbohydrate metabolic process	GO:0005975	230	0.129
glycosyl compound catabolic process	GO:1901658	206	0.129
regulation of organelle organization	GO:0033043	289	0.128	Human
positive regulation of wnt signaling pathway	GO:0030177	45	0.128
response to growth factor	GO:0070848	198	0.127
negative regulation of cellular protein metabolic process	GO:0032269	247	0.127
ear morphogenesis	GO:0042471	118	0.127	Mouse
endomembrane system organization	GO:0010256	147	0.126
membrane organization	GO:0061024	245	0.126
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.125
microtubule cytoskeleton organization	GO:0000226	157	0.125
positive regulation of muscle tissue development	GO:1901863	32	0.125
negative regulation of cell development	GO:0010721	169	0.125
nucleoside metabolic process	GO:0009116	246	0.125
cellular metal ion homeostasis	GO:0006875	151	0.124
regulation of synaptic plasticity	GO:0048167	87	0.123
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.122
cation transport	GO:0006812	399	0.122
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.122
inorganic ion transmembrane transport	GO:0098660	234	0.121
hippocampus development	GO:0021766	52	0.120
extracellular matrix organization	GO:0030198	147	0.119
lung cell differentiation	GO:0060479	30	0.119
trachea cartilage morphogenesis	GO:0060535	4	0.119
cardiac muscle tissue growth	GO:0055017	37	0.119
morphogenesis of a branching structure	GO:0001763	203	0.117	Mouse
neural precursor cell proliferation	GO:0061351	121	0.116
regulation of heart growth	GO:0060420	31	0.116
nucleoside phosphate metabolic process	GO:0006753	338	0.116	Mouse
mesoderm development	GO:0007498	100	0.115
nucleoside phosphate biosynthetic process	GO:1901293	79	0.115	Mouse
positive regulation of kinase activity	GO:0033674	155	0.114	Human
establishment of protein localization to organelle	GO:0072594	118	0.114
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	24	0.114
positive regulation of canonical wnt signaling pathway	GO:0090263	29	0.114
ventricular cardiac muscle tissue development	GO:0003229	38	0.113
negative regulation of synapse assembly	GO:0051964	3	0.111
organic hydroxy compound transport	GO:0015850	93	0.111
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.111
learning or memory	GO:0007611	148	0.110
dorsal spinal cord development	GO:0021516	20	0.110
skeletal muscle organ development	GO:0060538	163	0.110
divalent metal ion transport	GO:0070838	172	0.109
keratinocyte proliferation	GO:0043616	21	0.109
calcium ion homeostasis	GO:0055074	127	0.109
regulation of metal ion transport	GO:0010959	106	0.109
mammary gland epithelium development	GO:0061180	65	0.109
spermatogenesis	GO:0007283	284	0.108
ventral spinal cord development	GO:0021517	48	0.108
organelle fission	GO:0048285	170	0.108	Human
regulation of secretion	GO:0051046	274	0.107	Human Mouse
myelination	GO:0042552	74	0.106
hair follicle development	GO:0001942	85	0.106
regulation of morphogenesis of a branching structure	GO:0060688	53	0.106
nucleotide catabolic process	GO:0009166	217	0.106
regulation of establishment of protein localization	GO:0070201	181	0.106
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.106
regulation of cardiac muscle cell proliferation	GO:0060043	23	0.105
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.105
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.105
divalent inorganic cation transport	GO:0072511	178	0.105
extracellular structure organization	GO:0043062	148	0.104
notch signaling pathway	GO:0007219	71	0.103
positive regulation of protein modification process	GO:0031401	299	0.103	Human
positive regulation of striated muscle tissue development	GO:0045844	31	0.103
diencephalon development	GO:0021536	63	0.103
mitotic cell cycle	GO:0000278	195	0.103	Human
forebrain neuron differentiation	GO:0021879	52	0.103
plasma membrane organization	GO:0007009	90	0.102
molting cycle	GO:0042303	90	0.102
renal system development	GO:0072001	225	0.102
negative regulation of cell growth	GO:0030308	44	0.102
regulation of extent of cell growth	GO:0061387	52	0.101
protein secretion	GO:0009306	111	0.101
regulation of ion transport	GO:0043269	215	0.101
negative regulation of osteoblast differentiation	GO:0045668	30	0.101
cardiocyte differentiation	GO:0035051	87	0.101
negative regulation of growth	GO:0045926	99	0.101
positive regulation of apoptotic process	GO:0043065	217	0.100
epithelial tube branching involved in lung morphogenesis	GO:0060441	28	0.100
epithelial to mesenchymal transition	GO:0001837	47	0.100
protein localization to membrane	GO:0072657	108	0.099
axon ensheathment	GO:0008366	76	0.099
embryonic digestive tract morphogenesis	GO:0048557	17	0.099
positive regulation of angiogenesis	GO:0045766	46	0.099
heart growth	GO:0060419	45	0.099
regulation of protein localization	GO:0032880	231	0.098
heart process	GO:0003015	94	0.098	Human
hypothalamus development	GO:0021854	16	0.098
forebrain morphogenesis	GO:0048853	17	0.098
regulation of cell adhesion	GO:0030155	154	0.098
organophosphate catabolic process	GO:0046434	232	0.098
ribose phosphate biosynthetic process	GO:0046390	59	0.096	Mouse
tube closure	GO:0060606	91	0.096
purine ribonucleotide biosynthetic process	GO:0009152	59	0.096	Mouse
inner ear morphogenesis	GO:0042472	101	0.095
striated muscle cell proliferation	GO:0014855	39	0.095
somitogenesis	GO:0001756	69	0.095
calcium ion transmembrane transport	GO:0070588	85	0.095
renal vesicle induction	GO:0072034	3	0.095
cation homeostasis	GO:0055080	212	0.094
heterocycle catabolic process	GO:0046700	280	0.093
lung epithelium development	GO:0060428	37	0.092
regulation of nuclear division	GO:0051783	56	0.092	Human
erythrocyte differentiation	GO:0030218	88	0.092
brain morphogenesis	GO:0048854	32	0.091
g protein coupled receptor signaling pathway	GO:0007186	243	0.091	Mouse
positive regulation of cytokine production	GO:0001819	174	0.091
morphogenesis of a polarized epithelium	GO:0001738	37	0.091
regulation of cellular component size	GO:0032535	121	0.091
regulation of wnt signaling pathway	GO:0030111	123	0.090
embryonic heart tube development	GO:0035050	65	0.090
regulation of epidermal cell differentiation	GO:0045604	21	0.090
skin morphogenesis	GO:0043589	38	0.090
metanephros development	GO:0001656	79	0.090
tendon formation	GO:0035992	4	0.090
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.090
mammary gland duct morphogenesis	GO:0060603	38	0.089
epidermis morphogenesis	GO:0048730	33	0.089
metencephalon development	GO:0022037	89	0.089
blastocyst development	GO:0001824	80	0.088
embryonic genitalia morphogenesis	GO:0030538	4	0.088
response to transforming growth factor beta	GO:0071559	88	0.088
intracellular protein transport	GO:0006886	204	0.087
nucleoside triphosphate catabolic process	GO:0009143	205	0.087
regulation of transmembrane transport	GO:0034762	128	0.087
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.086
regulation of fat cell differentiation	GO:0045598	81	0.086
establishment or maintenance of cell polarity	GO:0007163	86	0.086
ribonucleoside metabolic process	GO:0009119	245	0.086
mesoderm formation	GO:0001707	62	0.085
lens development in camera type eye	GO:0002088	62	0.085
activation of adenylate cyclase activity	GO:0007190	4	0.085
protein localization to nucleus	GO:0034504	121	0.085
retina development in camera type eye	GO:0060041	119	0.084
positive regulation of cardiac muscle cell proliferation	GO:0060045	15	0.084
regulation of mapk cascade	GO:0043408	248	0.084	Human
regulation of stem cell differentiation	GO:2000736	50	0.084
protein localization to organelle	GO:0033365	185	0.084
gtp metabolic process	GO:0046039	144	0.083
cellular calcium ion homeostasis	GO:0006874	119	0.083
neural tube development	GO:0021915	160	0.083
divalent inorganic cation homeostasis	GO:0072507	138	0.083
positive regulation of cell migration	GO:0030335	109	0.082	Human
lung pattern specification process	GO:0060432	1	0.082
ear development	GO:0043583	200	0.082	Mouse
positive regulation of transferase activity	GO:0051347	167	0.082	Human
positive regulation of cardiac muscle tissue growth	GO:0055023	15	0.081
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.081
male genitalia morphogenesis	GO:0048808	4	0.081
regulation of lymphocyte activation	GO:0051249	240	0.081
mammary gland epithelial cell differentiation	GO:0060644	13	0.081
purine containing compound catabolic process	GO:0072523	213	0.081
regulation of protein secretion	GO:0050708	82	0.080
regulation of neural precursor cell proliferation	GO:2000177	70	0.080
cerebellum development	GO:0021549	77	0.080
regulation of ras protein signal transduction	GO:0046578	114	0.080
bronchiole morphogenesis	GO:0060436	1	0.080
stem cell maintenance	GO:0019827	130	0.079
positive regulation of nucleotide metabolic process	GO:0045981	114	0.079
glucose homeostasis	GO:0042593	128	0.079
positive regulation of ossification	GO:0045778	47	0.079
purine nucleoside metabolic process	GO:0042278	241	0.078
ribonucleotide biosynthetic process	GO:0009260	59	0.078	Mouse
kidney development	GO:0001822	213	0.078
positive regulation of cell adhesion	GO:0045785	80	0.078
positive regulation of gtpase activity	GO:0043547	85	0.077
negative regulation of myeloid cell differentiation	GO:0045638	38	0.077
phenol containing compound metabolic process	GO:0018958	60	0.076
macromolecule catabolic process	GO:0009057	281	0.076
negative regulation of ossification	GO:0030279	49	0.076
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.076
positive regulation of epithelial cell proliferation	GO:0050679	68	0.075
appendage morphogenesis	GO:0035107	149	0.075
placenta development	GO:0001890	140	0.075
embryonic skeletal system morphogenesis	GO:0048704	91	0.075
developmental growth involved in morphogenesis	GO:0060560	138	0.075
multi organism reproductive behavior	GO:0044705	29	0.075
negative regulation of cell morphogenesis involved in differentiation	GO:0010771	48	0.074
regulation of blood pressure	GO:0008217	93	0.074	Human Mouse
regulation of cell cycle	GO:0051726	281	0.074	Human
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.074
regulation of cellular catabolic process	GO:0031329	242	0.074
axial mesoderm formation	GO:0048320	3	0.074
nucleoside triphosphate metabolic process	GO:0009141	230	0.073
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.073
skeletal muscle cell differentiation	GO:0035914	66	0.073
regulation of chromosome organization	GO:0033044	83	0.073
hormone secretion	GO:0046879	128	0.073	Human
tissue homeostasis	GO:0001894	115	0.072
calcium ion transport	GO:0006816	159	0.071
hair cycle	GO:0042633	90	0.071
carbohydrate homeostasis	GO:0033500	128	0.071
positive regulation of lymphocyte activation	GO:0051251	140	0.071
embryonic placenta development	GO:0001892	98	0.071
somatic stem cell maintenance	GO:0035019	47	0.071
regulation of angiogenesis	GO:0045765	81	0.070
gonadotrophin releasing hormone neuronal migration to the hypothalamus	GO:0021828	3	0.070
nucleoside phosphate catabolic process	GO:1901292	222	0.070
cyclic purine nucleotide metabolic process	GO:0052652	43	0.070	Mouse
positive regulation of protein kinase b signaling	GO:0051897	32	0.069
negative regulation of protein metabolic process	GO:0051248	282	0.069
skeletal system morphogenesis	GO:0048705	203	0.069
cerebral cortex cell migration	GO:0021795	44	0.069
connective tissue development	GO:0061448	179	0.069	Mouse
regulation of branching involved in salivary gland morphogenesis	GO:0060693	11	0.069
posttranscriptional regulation of gene expression	GO:0010608	155	0.069
purine nucleoside catabolic process	GO:0006152	205	0.068
tertiary branching involved in mammary gland duct morphogenesis	GO:0060748	3	0.068
nephron development	GO:0072006	109	0.067
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.067
development of primary sexual characteristics	GO:0045137	143	0.067
oligodendrocyte differentiation	GO:0048709	53	0.067
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.067
liver development	GO:0001889	66	0.067
regulation of cell cycle process	GO:0010564	160	0.066	Human
positive regulation of cyclic nucleotide metabolic process	GO:0030801	24	0.066
ensheathment of neurons	GO:0007272	76	0.066
positive regulation of heart rate by epinephrine norepinephrine	GO:0001996	4	0.066
metal ion homeostasis	GO:0055065	189	0.066
generation of precursor metabolites and energy	GO:0006091	103	0.066
regulation of endothelial cell proliferation	GO:0001936	23	0.066
glycoprotein metabolic process	GO:0009100	116	0.066
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072039	4	0.064
morphogenesis of an epithelial fold	GO:0060571	28	0.064
regulation of auditory receptor cell differentiation	GO:0045607	4	0.064
organelle assembly	GO:0070925	177	0.064
t cell differentiation in thymus	GO:0033077	77	0.063
peptide hormone secretion	GO:0030072	109	0.063	Human
semaphorin plexin signaling pathway	GO:0071526	21	0.063
positive regulation of cell cycle	GO:0045787	92	0.063	Human
negative regulation of protein phosphorylation	GO:0001933	126	0.063
nephron morphogenesis	GO:0072028	69	0.063
positive regulation of protein kinase activity	GO:0045860	144	0.062	Human
regulation of bone mineralization	GO:0030500	31	0.062
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.062
reproductive behavior	GO:0019098	32	0.062
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000802	1	0.062
negative regulation of wnt signaling pathway	GO:0030178	73	0.062

Edn3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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