IMP: Integrative Multi-species Prediction

Mus musculus

197 known processes

Egr2

early growth response 2

(Aliases: Krox20,Krox-20,Zfp-6,Egr-2,Zfp-25,NGF1-B)

Entrez: 13654
Ensembl: ENSMUSG00000037868
UniProtKB: P08152
UniProtKB: Q3U207

Process Predictions
Disease Predictions

Egr2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ensheathment of neurons	GO:0007272	76	0.992
schwann cell differentiation	GO:0014037	26	0.987
rhombomere 5 development	GO:0021571	4	0.984
neuronal action potential	GO:0019228	54	0.973
multicellular organismal signaling	GO:0035637	91	0.970
transmission of nerve impulse	GO:0019226	76	0.968
axon ensheathment	GO:0008366	76	0.959
myelination	GO:0042552	74	0.957
regulation of ovulation	GO:0060278	3	0.957	Worm
regulation of transcription from rna polymerase iii promoter	GO:0006359	2	0.953
action potential	GO:0001508	78	0.935
rhombomere morphogenesis	GO:0021593	2	0.931
gliogenesis	GO:0042063	141	0.920
facial nerve structural organization	GO:0021612	10	0.882
skeletal system development	GO:0001501	356	0.875
negative regulation of ovulation	GO:0060280	1	0.873	Worm
rhombomere 3 development	GO:0021569	4	0.870
skeletal system morphogenesis	GO:0048705	203	0.865
glial cell differentiation	GO:0010001	131	0.839
regulation of defense response	GO:0031347	233	0.833
peripheral nervous system development	GO:0007422	53	0.819
facial nerve development	GO:0021561	11	0.812
muscle tissue development	GO:0060537	308	0.800
skeletal muscle cell differentiation	GO:0035914	66	0.764
facial nerve morphogenesis	GO:0021610	11	0.731
chemotaxis	GO:0006935	247	0.727
transcription from rna polymerase iii promoter	GO:0006383	3	0.723
rhombomere 3 morphogenesis	GO:0021658	2	0.708
adrenal cortex formation	GO:0035802	2	0.684	Mouse
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.675
regulation of leukocyte differentiation	GO:1902105	159	0.665	Mouse
regulation of cell activation	GO:0050865	289	0.656	Mouse
endochondral bone morphogenesis	GO:0060350	50	0.651
regulation of cellular catabolic process	GO:0031329	242	0.631
regulation of t cell differentiation	GO:0045580	83	0.629	Mouse
regulation of membrane potential	GO:0042391	192	0.628
metanephric glomerular mesangium development	GO:0072223	3	0.625	Mouse
parasympathetic nervous system development	GO:0048486	19	0.614
cellular macromolecule catabolic process	GO:0044265	206	0.599
ossification	GO:0001503	216	0.598
adrenal cortex development	GO:0035801	2	0.588	Mouse
cellular response to gamma radiation	GO:0071480	4	0.576	Mouse
leukocyte differentiation	GO:0002521	342	0.572	Mouse
replacement ossification	GO:0036075	26	0.559
central nervous system segmentation	GO:0035283	3	0.547
negative regulation of metanephric glomerulus development	GO:0072299	1	0.536	Mouse
protein modification by small protein conjugation or removal	GO:0070647	207	0.534
bone development	GO:0060348	120	0.530
thorax and anterior abdomen determination	GO:0007356	1	0.519	Mouse
cellular response to acid chemical	GO:0071229	68	0.518
regulation of transferase activity	GO:0051338	263	0.518	Worm
nerve development	GO:0021675	67	0.512
rhombomere 5 formation	GO:0021666	1	0.512
cranial nerve structural organization	GO:0021604	13	0.511
lymphocyte differentiation	GO:0030098	242	0.479	Mouse
regulation of epidermis development	GO:0045682	33	0.475
regulation of kinase activity	GO:0043549	249	0.457	Worm
bone morphogenesis	GO:0060349	78	0.450
protein modification by small protein conjugation	GO:0032446	187	0.445
positive regulation of leukocyte differentiation	GO:1902107	86	0.443	Mouse
positive regulation of cell activation	GO:0050867	158	0.441	Mouse
mitotic cell cycle process	GO:1903047	159	0.437
regulation of map kinase activity	GO:0043405	120	0.433	Worm
compound eye development	GO:0048749	1	0.431
axon guidance	GO:0007411	141	0.424
skeletal muscle organ development	GO:0060538	163	0.421
placenta development	GO:0001890	140	0.405
hindbrain development	GO:0030902	128	0.386
positive regulation of metanephric ureteric bud development	GO:2001076	1	0.379	Mouse
gland development	GO:0048732	330	0.374	Mouse
t cell differentiation in thymus	GO:0033077	77	0.360	Mouse
skin development	GO:0043588	220	0.356
oligodendrocyte differentiation	GO:0048709	53	0.350
regulation of cell cycle	GO:0051726	281	0.344
positive regulation of defense response	GO:0031349	124	0.342
nuclear transport	GO:0051169	139	0.339
digestive tract development	GO:0048565	190	0.337
blood vessel morphogenesis	GO:0048514	285	0.325	Mouse
regulation of protein localization	GO:0032880	231	0.323
axonogenesis	GO:0007409	274	0.321
negative regulation of molecular function	GO:0044092	258	0.316	Worm
protein sumoylation	GO:0016925	14	0.312
gonad development	GO:0008406	141	0.311	Mouse
positive regulation of osteoclast differentiation	GO:0045672	15	0.304
regulation of cellular response to stress	GO:0080135	159	0.302
regulation of protein serine threonine kinase activity	GO:0071900	157	0.294	Worm
t cell differentiation	GO:0030217	174	0.294	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.277
kidney epithelium development	GO:0072073	121	0.273	Mouse
intracellular receptor signaling pathway	GO:0030522	74	0.272
cellular response to lipid	GO:0071396	145	0.269
striated muscle tissue development	GO:0014706	293	0.267
regulation of t cell differentiation in thymus	GO:0033081	24	0.263	Mouse
regulation of ossification	GO:0030278	112	0.261
positive regulation of t cell activation	GO:0050870	101	0.260	Mouse
response to growth factor	GO:0070848	198	0.259
negative regulation of cell cycle	GO:0045786	123	0.255
negative regulation of protein phosphorylation	GO:0001933	126	0.252	Worm
positive regulation of cellular catabolic process	GO:0031331	148	0.252
cell growth	GO:0016049	130	0.250
anatomical structure arrangement	GO:0048532	20	0.249
negative regulation of map kinase activity	GO:0043407	34	0.247	Worm
fat cell differentiation	GO:0045444	160	0.246
positive regulation of growth	GO:0045927	104	0.242	Mouse
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.241
modification dependent macromolecule catabolic process	GO:0043632	133	0.238
response to organonitrogen compound	GO:0010243	246	0.237	Mouse Rat
negative regulation of phosphate metabolic process	GO:0045936	184	0.233	Worm
positive regulation of cell death	GO:0010942	224	0.230
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.228
mitotic cell cycle	GO:0000278	195	0.227
cellular response to radiation	GO:0071478	28	0.227	Mouse
regulation of cyclin dependent protein serine threonine kinase activity involved in g2 m transition of mitotic cell cycle	GO:0031660	1	0.226
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.223
lateral line system development	GO:0048925	1	0.223	Zebrafish
telencephalon development	GO:0021537	186	0.222
gamma delta t cell differentiation	GO:0042492	11	0.222	Mouse
lateral line nerve development	GO:0048892	1	0.221	Zebrafish
response to molecule of bacterial origin	GO:0002237	143	0.220
positive regulation of nuclear transcribed mrna poly a tail shortening	GO:0060213	4	0.216
digestive system development	GO:0055123	200	0.213
single organism cell adhesion	GO:0098602	156	0.212
canonical wnt signaling pathway	GO:0060070	130	0.211	Mouse
cell fate commitment	GO:0045165	210	0.209	Mouse
jnk cascade	GO:0007254	72	0.207
heart morphogenesis	GO:0003007	178	0.203
negative regulation of cell proliferation	GO:0008285	296	0.200	Mouse
heart growth	GO:0060419	45	0.199	Mouse
negative regulation of fat cell differentiation	GO:0045599	36	0.198
cellular response to organonitrogen compound	GO:0071417	145	0.196
response to acid chemical	GO:0001101	111	0.192
rhythmic process	GO:0048511	174	0.190
positive regulation of t cell differentiation	GO:0045582	52	0.190	Mouse
pharynx development	GO:0060465	1	0.187
schwann cell development	GO:0014044	22	0.186
regulation of intracellular steroid hormone receptor signaling pathway	GO:0033143	18	0.186
cranial nerve development	GO:0021545	41	0.185
regulation of cellular amino acid metabolic process	GO:0006521	5	0.183
regulation of inflammatory response	GO:0050727	147	0.183
forebrain development	GO:0030900	302	0.181
cellular response to cytokine stimulus	GO:0071345	189	0.180
cytokine mediated signaling pathway	GO:0019221	115	0.179
positive regulation of t helper 1 cell differentiation	GO:0045627	4	0.178
regulation of transcription from rna polymerase ii promoter in response to hypoxia	GO:0061418	2	0.177	Mouse
female gonad development	GO:0008585	71	0.177	Mouse
nucleocytoplasmic transport	GO:0006913	139	0.176
regulation of establishment of protein localization	GO:0070201	181	0.175
mesenchyme development	GO:0060485	152	0.175	Mouse
stem cell differentiation	GO:0048863	268	0.171
myeloid cell differentiation	GO:0030099	233	0.169
positive regulation of apoptotic process	GO:0043065	217	0.169
regulation of mapk cascade	GO:0043408	248	0.166	Worm
negative regulation of defense response	GO:0031348	77	0.165
regulation of canonical wnt signaling pathway	GO:0060828	82	0.164	Mouse
kidney morphogenesis	GO:0060993	83	0.164	Mouse
phagocytosis	GO:0006909	66	0.162	Fly
heterocycle catabolic process	GO:0046700	280	0.162
osteoclast differentiation	GO:0030316	62	0.161
kidney development	GO:0001822	213	0.157	Mouse
response to camp	GO:0051591	14	0.157
nephron tubule morphogenesis	GO:0072078	68	0.156	Mouse
chromatin organization	GO:0006325	206	0.156
negative regulation of inflammatory response	GO:0050728	61	0.156
positive regulation of epithelial cell proliferation	GO:0050679	68	0.154
t cell activation	GO:0042110	289	0.154	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.154	Mouse
central nervous system neuron development	GO:0021954	67	0.150
rhombomere formation	GO:0021594	1	0.149
positive regulation of fibroblast proliferation	GO:0048146	20	0.148
axon regeneration	GO:0031103	12	0.147
negative regulation of cell cycle process	GO:0010948	69	0.147
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.147
negative regulation of immune system process	GO:0002683	209	0.145
development of primary sexual characteristics	GO:0045137	143	0.142	Mouse
fibroblast proliferation	GO:0048144	35	0.142
regulation of t cell activation	GO:0050863	170	0.141	Mouse
negative regulation of cell cycle phase transition	GO:1901988	48	0.141
regulation of apoptotic signaling pathway	GO:2001233	197	0.139
regulation of osteoblast differentiation	GO:0045667	67	0.139
motor neuron axon guidance	GO:0008045	26	0.138
cellular amine metabolic process	GO:0044106	44	0.137
cellular response to growth factor stimulus	GO:0071363	197	0.137
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.136
brain segmentation	GO:0035284	3	0.135
locomotory behavior	GO:0007626	195	0.132
response to heparin	GO:0071503	1	0.131
membrane organization	GO:0061024	245	0.131
genitalia development	GO:0048806	37	0.129	Mouse
cellular response to follicle stimulating hormone stimulus	GO:0071372	1	0.127
protein catabolic process	GO:0030163	221	0.127
regulation of neuron differentiation	GO:0045664	281	0.127
protein import into nucleus	GO:0006606	95	0.127
response to peptide hormone	GO:0043434	127	0.127	Mouse Rat
regulation of protein deacetylation	GO:0090311	17	0.126
vitellogenesis	GO:0007296	2	0.125
response to interleukin 1	GO:0070555	11	0.123
regulation of epithelial cell proliferation	GO:0050678	141	0.122
cell type specific apoptotic process	GO:0097285	268	0.122	Mouse
developmental growth involved in morphogenesis	GO:0060560	138	0.122
cranial nerve morphogenesis	GO:0021602	26	0.120
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.120
cellular response to extracellular stimulus	GO:0031668	81	0.120
stress activated protein kinase signaling cascade	GO:0031098	81	0.119
negative regulation of cellular protein metabolic process	GO:0032269	247	0.119	Worm
immune effector process	GO:0002252	321	0.118
placenta blood vessel development	GO:0060674	31	0.118
cellular response to dna damage stimulus	GO:0006974	207	0.117
gamma delta t cell activation	GO:0046629	13	0.117	Mouse
response to transforming growth factor beta	GO:0071559	88	0.116
olfactory lobe development	GO:0021988	32	0.116
regulation of response to wounding	GO:1903034	189	0.114
olfactory bulb development	GO:0021772	30	0.112
epidermis development	GO:0008544	187	0.111
response to organic cyclic compound	GO:0014070	198	0.111
inflammatory response	GO:0006954	244	0.110
embryonic viscerocranium morphogenesis	GO:0048703	8	0.109
cellular response to heparin	GO:0071504	1	0.108
oocyte differentiation	GO:0009994	35	0.107	Worm
regulation of organelle organization	GO:0033043	289	0.107
neuron apoptotic process	GO:0051402	142	0.106
posterior mesonephric tubule development	GO:0072166	2	0.106	Mouse
embryonic placenta development	GO:0001892	98	0.105
integrin mediated signaling pathway	GO:0007229	27	0.104
glial cell development	GO:0021782	54	0.104	Zebrafish
regulation of organ growth	GO:0046620	61	0.103	Mouse
nephron epithelium morphogenesis	GO:0072088	68	0.103	Mouse
multi multicellular organism process	GO:0044706	109	0.102
intracellular steroid hormone receptor signaling pathway	GO:0030518	29	0.101
negative regulation of protein modification process	GO:0031400	163	0.101	Worm
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.101
muscle system process	GO:0003012	141	0.101
cellular response to calcium ion	GO:0071277	14	0.099
germ cell development	GO:0007281	185	0.099	Mouse Worm
cellular ketone metabolic process	GO:0042180	84	0.099
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.098
regulation of glomerulus development	GO:0090192	6	0.098	Mouse
pericardium development	GO:0060039	16	0.098	Mouse
positive regulation of innate immune response	GO:0045089	80	0.098
glomerulus development	GO:0032835	40	0.097	Mouse
negative regulation of cellular amine metabolic process	GO:0033239	1	0.097
amine metabolic process	GO:0009308	45	0.096
branching morphogenesis of an epithelial tube	GO:0048754	159	0.096	Mouse
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.096	Worm
cellular response to insulin stimulus	GO:0032869	78	0.095
cellular response to external stimulus	GO:0071496	88	0.095
central nervous system morphogenesis	GO:0021551	2	0.095
regulation of chromosome organization	GO:0033044	83	0.095
sertoli cell differentiation	GO:0060008	18	0.094	Mouse
establishment of protein localization to organelle	GO:0072594	118	0.094
negative regulation of wnt signaling pathway	GO:0030178	73	0.094	Mouse
regulation of fibroblast proliferation	GO:0048145	34	0.094
regulation of peptidase activity	GO:0052547	96	0.093
regulation of gamma delta t cell activation	GO:0046643	9	0.093	Mouse
carbohydrate transport	GO:0008643	62	0.092
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.091
regulation of protein sumoylation	GO:0033233	4	0.090
positive regulation of rho gtpase activity	GO:0032321	41	0.090
circadian rhythm	GO:0007623	114	0.090
apoptotic signaling pathway	GO:0097190	306	0.089
central nervous system neuron axonogenesis	GO:0021955	28	0.089
positive regulation of transcription from rna polymerase i promoter	GO:0045943	3	0.089
regulation of proteolysis	GO:0030162	164	0.089
mitotic cell cycle checkpoint	GO:0007093	31	0.088
positive regulation of cell development	GO:0010720	237	0.088
mesonephric epithelium development	GO:0072163	94	0.088	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.088	Mouse
ovulation	GO:0030728	15	0.087	Worm
negative regulation of multi organism process	GO:0043901	68	0.087	Worm
glycosyl compound metabolic process	GO:1901657	246	0.085
angiogenesis	GO:0001525	201	0.085
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.085	Mouse
response to amino acid	GO:0043200	37	0.085
ureteric bud morphogenesis	GO:0060675	62	0.084	Mouse
positive regulation of nucleotide metabolic process	GO:0045981	114	0.083
nucleotide metabolic process	GO:0009117	332	0.083
central nervous system neuron differentiation	GO:0021953	162	0.083
regulation of glomerular mesangial cell proliferation	GO:0072124	1	0.083	Mouse
negative regulation of lymphocyte differentiation	GO:0045620	32	0.083
cell differentiation involved in kidney development	GO:0061005	33	0.083	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.082
regulation of dna templated transcription in response to stress	GO:0043620	9	0.082	Mouse
regulation of heart growth	GO:0060420	31	0.081	Mouse
regulation of neuronal synaptic plasticity	GO:0048168	30	0.081	Rat
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.080
protein localization to organelle	GO:0033365	185	0.079
cytokine production	GO:0001816	319	0.079
nucleoside phosphate metabolic process	GO:0006753	338	0.079
positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:1900153	5	0.079
synapse organization	GO:0050808	125	0.079
negative regulation of mesenchymal cell apoptotic process involved in metanephros development	GO:1900212	4	0.078	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.078	Mouse
regulation of translation	GO:0006417	71	0.078
autonomic nervous system development	GO:0048483	43	0.078
reactive oxygen species biosynthetic process	GO:1903409	8	0.078
neural tube development	GO:0021915	160	0.077
cell maturation	GO:0048469	127	0.076	Worm
positive regulation of inflammatory response	GO:0050729	47	0.076
regulation of chromatin modification	GO:1903308	57	0.076
regulation of protein transport	GO:0051223	163	0.076
adult behavior	GO:0030534	135	0.076
regulation of intracellular transport	GO:0032386	159	0.076
positive regulation of proteolysis	GO:0045862	85	0.076
regulation of metanephric glomerulus development	GO:0072298	5	0.075	Mouse
cellular response to hormone stimulus	GO:0032870	150	0.075
negative regulation of nf kappab transcription factor activity	GO:0032088	15	0.075
response to purine containing compound	GO:0014074	28	0.075
single fertilization	GO:0007338	82	0.074	Mouse
organ growth	GO:0035265	117	0.074	Mouse
epithelial tube formation	GO:0072175	130	0.074
regulation of leukocyte apoptotic process	GO:2000106	56	0.074
negative regulation of t cell differentiation	GO:0045581	23	0.073
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.073
regulation of cell cycle phase transition	GO:1901987	77	0.073
single organismal cell cell adhesion	GO:0016337	131	0.073
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.072
cellular amino acid metabolic process	GO:0006520	103	0.072
cellular response to ionizing radiation	GO:0071479	11	0.071	Mouse
cellular response to antibiotic	GO:0071236	4	0.071
humoral immune response	GO:0006959	57	0.071
response to lipopolysaccharide	GO:0032496	128	0.071
negative regulation of leukocyte differentiation	GO:1902106	51	0.071
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	8	0.071	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.071
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.070
hippocampus development	GO:0021766	52	0.070
preganglionic parasympathetic nervous system development	GO:0021783	17	0.069
fertilization	GO:0009566	127	0.069	Mouse
rna splicing	GO:0008380	54	0.069	Mouse
forebrain cell migration	GO:0021885	58	0.069
negative regulation of protein kinase activity by regulation of protein phosphorylation	GO:0044387	2	0.068
intrinsic apoptotic signaling pathway	GO:0097193	132	0.068
osteoblast development	GO:0002076	17	0.068
regulation of cell migration	GO:0030334	219	0.068
regulation of neuron projection development	GO:0010975	169	0.068
mesonephric tubule development	GO:0072164	94	0.068	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.067
ureteric bud development	GO:0001657	94	0.067	Mouse
negative regulation of neuron apoptotic process	GO:0043524	92	0.067
response to drug	GO:0042493	75	0.066
proteoglycan metabolic process	GO:0006029	38	0.066
positive regulation of reproductive process	GO:2000243	19	0.066	Mouse
olfactory learning	GO:0008355	2	0.066
purine ribonucleotide catabolic process	GO:0009154	208	0.066
negative regulation of mitotic cell cycle	GO:0045930	58	0.065
regulation of mitotic cell cycle	GO:0007346	126	0.065
neuron projection guidance	GO:0097485	141	0.065
male gamete generation	GO:0048232	285	0.065	Mouse
carbohydrate metabolic process	GO:0005975	230	0.065
maintenance of location	GO:0051235	89	0.065
regulation of lymphocyte differentiation	GO:0045619	107	0.065	Mouse
long term synaptic potentiation	GO:0060291	25	0.063
nephron epithelium development	GO:0072009	92	0.063	Mouse
positive regulation of cytokine production	GO:0001819	174	0.063
cardiac cell fate commitment	GO:0060911	10	0.063	Mouse
cell cycle g1 s phase transition	GO:0044843	57	0.063
cellular homeostasis	GO:0019725	240	0.063
cellular response to abiotic stimulus	GO:0071214	56	0.062	Mouse
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.062
interleukin 1 mediated signaling pathway	GO:0070498	4	0.062
purine nucleotide metabolic process	GO:0006163	302	0.062
positive regulation of histone modification	GO:0031058	28	0.062
development of primary female sexual characteristics	GO:0046545	73	0.062	Mouse
negative regulation of neuron death	GO:1901215	98	0.062
divalent inorganic cation transport	GO:0072511	178	0.062
male sex differentiation	GO:0046661	109	0.061	Mouse
response to insulin	GO:0032868	100	0.061	Mouse Rat
regulation of organ morphogenesis	GO:2000027	144	0.061	Mouse
negative regulation of protein metabolic process	GO:0051248	282	0.061	Worm
nephron development	GO:0072006	109	0.060	Mouse
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	23	0.060
hexose metabolic process	GO:0019318	98	0.060
posttranscriptional regulation of gene expression	GO:0010608	155	0.060
response to amine	GO:0014075	16	0.060
cellular nitrogen compound catabolic process	GO:0044270	280	0.059
t cell proliferation	GO:0042098	120	0.059
positive regulation of cell adhesion	GO:0045785	80	0.059
metanephric nephron morphogenesis	GO:0072273	19	0.059	Mouse
regulation of cytokine production	GO:0001817	266	0.059
cardiac muscle cell differentiation	GO:0055007	69	0.059	Mouse
positive regulation of myeloid cell differentiation	GO:0045639	43	0.059
t cell activation involved in immune response	GO:0002286	43	0.059
regulation of cell cycle process	GO:0010564	160	0.059
cellular response to amino acid stimulus	GO:0071230	29	0.059
sequestering of metal ion	GO:0051238	19	0.058
mesonephros development	GO:0001823	97	0.058	Mouse
intracellular protein transport	GO:0006886	204	0.058
metencephalon development	GO:0022037	89	0.058
negative regulation of intracellular steroid hormone receptor signaling pathway	GO:0033144	11	0.058
glomerular mesangial cell proliferation	GO:0072110	3	0.058	Mouse
mitotic g2 dna damage checkpoint	GO:0007095	8	0.058
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.057
oocyte axis specification	GO:0007309	2	0.057
sensory organ morphogenesis	GO:0090596	242	0.057
oocyte development	GO:0048599	33	0.057	Worm
mammary gland morphogenesis	GO:0060443	54	0.056
aromatic compound catabolic process	GO:0019439	286	0.056
morphogenesis of a branching structure	GO:0001763	203	0.056	Mouse
hepaticobiliary system development	GO:0061008	67	0.056
positive regulation of hydrolase activity	GO:0051345	148	0.056
response to catecholamine	GO:0071869	4	0.056
positive regulation of organelle organization	GO:0010638	128	0.056
purine containing compound metabolic process	GO:0072521	311	0.055
proteasomal protein catabolic process	GO:0010498	98	0.055
positive regulation of male gonad development	GO:2000020	6	0.055	Mouse
regulation of myeloid cell differentiation	GO:0045637	96	0.055
metanephric s shaped body morphogenesis	GO:0072284	2	0.055	Mouse
regulation of cell adhesion	GO:0030155	154	0.055
forebrain neuron differentiation	GO:0021879	52	0.055
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.055
regulation of hydrolase activity	GO:0051336	246	0.054
positive regulation of transforming growth factor beta2 production	GO:0032915	2	0.054
second messenger mediated signaling	GO:0019932	73	0.054
dendrite development	GO:0016358	115	0.054
pallium development	GO:0021543	120	0.054
female gamete generation	GO:0007292	74	0.054	Worm
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.054
leukocyte migration	GO:0050900	124	0.054
regulation of neuron apoptotic process	GO:0043523	122	0.054
regulation of intrinsic apoptotic signaling pathway in response to dna damage	GO:1902229	14	0.054
cognition	GO:0050890	149	0.054	Rat
cell adhesion	GO:0007155	329	0.053
i kappab kinase nf kappab signaling	GO:0007249	85	0.053
metanephric part of ureteric bud development	GO:0035502	2	0.053	Mouse
nephron morphogenesis	GO:0072028	69	0.053	Mouse
regulation of metal ion transport	GO:0010959	106	0.052
glycosyl compound catabolic process	GO:1901658	206	0.052
mesenchymal cell development	GO:0014031	93	0.052
negative regulation of homeostatic process	GO:0032845	71	0.052
wnt signaling pathway	GO:0016055	188	0.052	Mouse
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.051
vascular process in circulatory system	GO:0003018	62	0.051
positive regulation of heart growth	GO:0060421	18	0.051	Mouse
response to ethanol	GO:0045471	18	0.051
positive regulation of neuron apoptotic process	GO:0043525	25	0.050
regulation of mesenchymal cell apoptotic process involved in metanephros development	GO:1900211	4	0.050	Mouse
guanosine containing compound catabolic process	GO:1901069	144	0.050
stem cell development	GO:0048864	219	0.050
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.050
regulation of nucleotide metabolic process	GO:0006140	169	0.050
hindbrain morphogenesis	GO:0021575	46	0.050	Zebrafish
cell fate specification	GO:0001708	72	0.050
regulation of neuron death	GO:1901214	134	0.050
chorio allantoic fusion	GO:0060710	8	0.050
myotube differentiation	GO:0014902	105	0.050
regulation of leukocyte proliferation	GO:0070663	121	0.050
cellular response to metal ion	GO:0071248	31	0.050
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.050
rna processing	GO:0006396	105	0.049	Mouse
synapse assembly	GO:0007416	56	0.049
regulation of purine nucleotide catabolic process	GO:0033121	122	0.049
chemokine production	GO:0032602	34	0.049
regulation of cellular protein catabolic process	GO:1903362	61	0.049
leukocyte proliferation	GO:0070661	172	0.049
regulation of myotube differentiation	GO:0010830	62	0.049
regulation of endothelial cell proliferation	GO:0001936	23	0.049
mesenchymal cell differentiation	GO:0048762	107	0.049
negative regulation of nervous system development	GO:0051961	156	0.048
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.048
regulation of cell substrate adhesion	GO:0010810	73	0.048
negative regulation of phosphorylation	GO:0042326	166	0.048	Worm
circulatory system process	GO:0003013	197	0.048
cellular response to gonadotropin stimulus	GO:0071371	4	0.048
cardiac chamber morphogenesis	GO:0003206	93	0.048
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.048
regulation of brown fat cell differentiation	GO:0090335	5	0.048
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.048
sensory system development	GO:0048880	3	0.047	Zebrafish
protein localization to nucleus	GO:0034504	121	0.047
cell cycle checkpoint	GO:0000075	47	0.047
muscle cell differentiation	GO:0042692	261	0.047	Mouse
protein maturation	GO:0051604	176	0.047
positive regulation of transferase activity	GO:0051347	167	0.047
neuron death	GO:0070997	154	0.046
response to alcohol	GO:0097305	48	0.046
ubiquitin dependent protein catabolic process	GO:0006511	129	0.046
activation of transmembrane receptor protein tyrosine kinase activity	GO:0007171	3	0.046
positive regulation of protein catabolic process	GO:0045732	60	0.046
nuclear export	GO:0051168	34	0.046
early endosome to late endosome transport	GO:0045022	2	0.046
nucleoside triphosphate catabolic process	GO:0009143	205	0.045
neuromuscular process	GO:0050905	99	0.045
regulation of reproductive process	GO:2000241	66	0.045	Mouse Worm
kidney vasculature development	GO:0061440	15	0.045	Mouse
regulation of nucleoside metabolic process	GO:0009118	130	0.045
regulation of striated muscle cell differentiation	GO:0051153	81	0.045
response to inorganic substance	GO:0010035	96	0.045
negative regulation of mapk cascade	GO:0043409	65	0.045	Worm
cd4 positive alpha beta t cell activation	GO:0035710	45	0.045

Egr2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
neuromuscular disease	DOID:440	0.473	Human
disease of anatomical entity	DOID:7	0.473	Human
nervous system disease	DOID:863	0.473	Human
neuropathy	DOID:870	0.473	Human
charcot marie tooth disease	DOID:10595	0.424	Human
cancer	DOID:162	0.071
disease of cellular proliferation	DOID:14566	0.071
organ system cancer	DOID:0050686	0.071
physical disorder	DOID:0080015	0.060
congenital nervous system abnormality	DOID:2490	0.060
immune system disease	DOID:2914	0.054

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