IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Eif2b4

eukaryotic translation initiation factor 2B, subunit 4 delta

(Aliases: Eif2b)

Ensembl: ENSMUSG00000029145
Entrez: 13667
UniProtKB: Q61749

Process Predictions
Disease Predictions

Eif2b4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
pyridine containing compound catabolic process	GO:0072526	4	0.103
pyridoxal phosphate catabolic process	GO:0032361	1	0.094
small gtpase mediated signal transduction	GO:0007264	97	0.090
cellular amine metabolic process	GO:0044106	44	0.078
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.061
heterocycle catabolic process	GO:0046700	280	0.060
translation	GO:0006412	93	0.060
nucleoside triphosphate metabolic process	GO:0009141	230	0.058
positive regulation of cellular amine metabolic process	GO:0033240	5	0.056
cellular amino acid metabolic process	GO:0006520	103	0.055
translational initiation	GO:0006413	24	0.054
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.051
purine containing compound metabolic process	GO:0072521	311	0.050
purine nucleoside catabolic process	GO:0006152	205	0.049
protein modification by small protein conjugation	GO:0032446	187	0.048
mitotic cell cycle	GO:0000278	195	0.048
regulation of cellular amino acid metabolic process	GO:0006521	5	0.047
aromatic compound catabolic process	GO:0019439	286	0.047
purine nucleoside metabolic process	GO:0042278	241	0.047
cellular nitrogen compound catabolic process	GO:0044270	280	0.044
cellular protein complex assembly	GO:0043623	116	0.044
purine nucleotide metabolic process	GO:0006163	302	0.041
regulation of cellular amine metabolic process	GO:0033238	20	0.040
purine containing compound catabolic process	GO:0072523	213	0.037
nucleoside monophosphate metabolic process	GO:0009123	85	0.036
regulation of translation	GO:0006417	71	0.036
trna aminoacylation for protein translation	GO:0006418	1	0.035
positive regulation of protein modification process	GO:0031401	299	0.035
amine metabolic process	GO:0009308	45	0.034
gland development	GO:0048732	330	0.034
carbohydrate derivative catabolic process	GO:1901136	231	0.031
regulation of cellular ketone metabolic process	GO:0010565	66	0.031
regulation of membrane potential	GO:0042391	192	0.030
macromolecule catabolic process	GO:0009057	281	0.030
glycosyl compound catabolic process	GO:1901658	206	0.029
negative regulation of protein metabolic process	GO:0051248	282	0.029
protein ubiquitination	GO:0016567	171	0.029
amino acid activation	GO:0043038	1	0.029
organic cyclic compound catabolic process	GO:1901361	295	0.029
cytoplasmic translational initiation	GO:0002183	3	0.028
cellular response to dna damage stimulus	GO:0006974	207	0.028
rna processing	GO:0006396	105	0.028
posttranscriptional regulation of gene expression	GO:0010608	155	0.027
ras protein signal transduction	GO:0007265	77	0.026
regulation of feeding behavior	GO:0060259	3	0.026
neuronal action potential	GO:0019228	54	0.026
organonitrogen compound catabolic process	GO:1901565	264	0.026
trna aminoacylation	GO:0043039	1	0.025
organophosphate catabolic process	GO:0046434	232	0.025
nucleoside phosphate catabolic process	GO:1901292	222	0.023
protein polymerization	GO:0051258	57	0.023
regulation of ras protein signal transduction	GO:0046578	114	0.023
regulation of hydrolase activity	GO:0051336	246	0.023
nucleotide catabolic process	GO:0009166	217	0.022
negative regulation of cell proliferation	GO:0008285	296	0.022
ribonucleotide catabolic process	GO:0009261	208	0.022
purine ribonucleotide metabolic process	GO:0009150	290	0.021
leukocyte differentiation	GO:0002521	342	0.021
glycosyl compound metabolic process	GO:1901657	246	0.021
regulation of neuron death	GO:1901214	134	0.021
regulation of cellular component biogenesis	GO:0044087	181	0.021
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.021
negative regulation of neuron apoptotic process	GO:0043524	92	0.021
organelle fission	GO:0048285	170	0.020
ribonucleoside catabolic process	GO:0042454	206	0.020
nucleobase containing small molecule metabolic process	GO:0055086	352	0.020
ribonucleotide metabolic process	GO:0009259	291	0.020
development of primary sexual characteristics	GO:0045137	143	0.020
neuron apoptotic process	GO:0051402	142	0.019
dna templated transcription initiation	GO:0006352	13	0.019
chromatin organization	GO:0006325	206	0.019
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.019
regulation of organelle organization	GO:0033043	289	0.019
ribose phosphate metabolic process	GO:0019693	291	0.019
negative regulation of cell cycle	GO:0045786	123	0.019
regulation of mitotic cell cycle	GO:0007346	126	0.019
cellular ketone metabolic process	GO:0042180	84	0.019
chromatin modification	GO:0016568	187	0.019
ribonucleoside metabolic process	GO:0009119	245	0.019
multicellular organismal signaling	GO:0035637	91	0.019
dna metabolic process	GO:0006259	303	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.018
nucleotide metabolic process	GO:0009117	332	0.017
cell division	GO:0051301	120	0.017
regulation of lymphocyte activation	GO:0051249	240	0.017
cytokine production	GO:0001816	319	0.017
germ cell development	GO:0007281	185	0.017
transmission of nerve impulse	GO:0019226	76	0.016
gonad development	GO:0008406	141	0.016
nucleoside metabolic process	GO:0009116	246	0.016
action potential	GO:0001508	78	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.016
rna catabolic process	GO:0006401	29	0.016
purine ribonucleoside catabolic process	GO:0046130	205	0.016
positive regulation of protein phosphorylation	GO:0001934	242	0.015
nuclear division	GO:0000280	158	0.015
negative regulation of intracellular signal transduction	GO:1902532	167	0.015
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.015
defecation	GO:0030421	1	0.015
ensheathment of neurons	GO:0007272	76	0.015
cellular macromolecule catabolic process	GO:0044265	206	0.014
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.014
purine ribonucleoside metabolic process	GO:0046128	241	0.014
embryonic organ morphogenesis	GO:0048562	276	0.014
response to organonitrogen compound	GO:0010243	246	0.014
positive regulation of hydrolase activity	GO:0051345	148	0.014
nucleoside triphosphate catabolic process	GO:0009143	205	0.014
rna interference	GO:0016246	2	0.014
regulation of protein complex assembly	GO:0043254	83	0.014
striated muscle tissue development	GO:0014706	293	0.014
regulation of cell activation	GO:0050865	289	0.014
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.014
blastocyst development	GO:0001824	80	0.014
actin cytoskeleton organization	GO:0030036	220	0.013
nucleoside catabolic process	GO:0009164	206	0.013
regulation of lymphocyte differentiation	GO:0045619	107	0.013
spindle assembly involved in meiosis	GO:0090306	4	0.013
male gamete generation	GO:0048232	285	0.013
cell type specific apoptotic process	GO:0097285	268	0.013
negative regulation of mammary gland epithelial cell proliferation	GO:0033600	3	0.013
peptidyl amino acid modification	GO:0018193	336	0.013
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.013
cellular homeostasis	GO:0019725	240	0.013
endocytosis	GO:0006897	168	0.013
regulation of homeostatic process	GO:0032844	182	0.013
regulation of t cell activation	GO:0050863	170	0.012
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.012
g protein coupled receptor signaling pathway	GO:0007186	243	0.012
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.012
transmembrane transport	GO:0055085	412	0.012
negative regulation of translational initiation	GO:0045947	4	0.012
muscle cell differentiation	GO:0042692	261	0.012
negative regulation of mitotic cell cycle	GO:0045930	58	0.012
immune effector process	GO:0002252	321	0.012
regulation of neuron apoptotic process	GO:0043523	122	0.012
mitotic cell cycle process	GO:1903047	159	0.012
regulation of actin filament based process	GO:0032970	99	0.012
nucleoside phosphate metabolic process	GO:0006753	338	0.012
gene silencing by rna	GO:0031047	19	0.011
sensory perception	GO:0007600	245	0.011
regulation of ion transport	GO:0043269	215	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.011
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.011
regulation of actin cytoskeleton organization	GO:0032956	84	0.011
response to organic cyclic compound	GO:0014070	198	0.011
negative regulation of cell cycle phase transition	GO:1901988	48	0.011
regulation of leukocyte differentiation	GO:1902105	159	0.011
negative regulation of epithelial cell proliferation	GO:0050680	64	0.011
stem cell differentiation	GO:0048863	268	0.011
response to radiation	GO:0009314	165	0.011
regulation of protein kinase activity	GO:0045859	232	0.011
central nervous system neuron differentiation	GO:0021953	162	0.011
purine nucleotide catabolic process	GO:0006195	211	0.011
purine ribonucleotide catabolic process	GO:0009154	208	0.011
rhythmic process	GO:0048511	174	0.011
organonitrogen compound biosynthetic process	GO:1901566	192	0.010
skeletal muscle organ development	GO:0060538	163	0.010
negative regulation of molecular function	GO:0044092	258	0.010
skin development	GO:0043588	220	0.010
nucleocytoplasmic transport	GO:0006913	139	0.010
cytoplasmic transport	GO:0016482	234	0.010
trna metabolic process	GO:0006399	11	0.010

Eif2b4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
neuropathy	DOID:870	0.032
nervous system disease	DOID:863	0.032
disease of anatomical entity	DOID:7	0.032
central nervous system disease	DOID:331	0.018
neuromuscular disease	DOID:440	0.016

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