IMP: Integrative Multi-species Prediction

Mus musculus

31 known processes

Eif3a

eukaryotic translation initiation factor 3, subunit A

(Aliases: A830012B05Rik,Eif3,Csma,Eif3s10,mKIAA0139)

Ensembl: ENSMUSG00000024991
Entrez: 13669
UniProtKB: P23116
UniProtKB: Q3TRH1
UniProtKB: Q3UM46

Process Predictions
Disease Predictions

Eif3a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
translational initiation	GO:0006413	24	1.000
translation	GO:0006412	93	0.998
regulation of translational initiation	GO:0006446	15	0.754
posttranscriptional regulation of gene expression	GO:0010608	155	0.500
regulation of translation	GO:0006417	71	0.469
ribonucleoprotein complex localization	GO:0071166	1	0.425
cellular response to cytokine stimulus	GO:0071345	189	0.350
cajal body organization	GO:0030576	1	0.276
establishment of meiotic spindle orientation	GO:0051296	1	0.242
oocyte construction	GO:0007308	2	0.209
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.185
regulation of mitotic cell cycle	GO:0007346	126	0.180
rna processing	GO:0006396	105	0.170
oocyte axis specification	GO:0007309	2	0.170
neuron apoptotic process	GO:0051402	142	0.161
ribonucleoprotein complex disassembly	GO:0032988	3	0.151
female gamete generation	GO:0007292	74	0.145
regulation of mrna splicing via spliceosome	GO:0048024	32	0.142
mitochondrion distribution	GO:0048311	4	0.126
ribonucleotide catabolic process	GO:0009261	208	0.125
organophosphate catabolic process	GO:0046434	232	0.123
regulation of organelle organization	GO:0033043	289	0.117
rna splicing	GO:0008380	54	0.116
purine nucleoside catabolic process	GO:0006152	205	0.115
purine ribonucleotide metabolic process	GO:0009150	290	0.113
purine nucleotide metabolic process	GO:0006163	302	0.108
intracellular mrna localization	GO:0008298	4	0.107
microtubule organizing center organization	GO:0031023	28	0.103
stem cell development	GO:0048864	219	0.101
maturation of ssu rrna	GO:0030490	1	0.097
maintenance of location	GO:0051235	89	0.095
stem cell differentiation	GO:0048863	268	0.094
mrna localization resulting in posttranscriptional regulation of gene expression	GO:0010609	2	0.092
cell division	GO:0051301	120	0.091
lipid storage	GO:0019915	36	0.087
intracellular distribution of mitochondria	GO:0048312	1	0.085
ossification	GO:0001503	216	0.083
germ cell development	GO:0007281	185	0.083
rna interference	GO:0016246	2	0.083
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.081
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.080
gene silencing by rna	GO:0031047	19	0.078
nucleoside monophosphate metabolic process	GO:0009123	85	0.077
meiotic nuclear division	GO:0007126	115	0.075
regulation of protein localization	GO:0032880	231	0.074
regulation of cell cycle	GO:0051726	281	0.066
organonitrogen compound catabolic process	GO:1901565	264	0.062
chromatin organization	GO:0006325	206	0.060
innate immune response	GO:0045087	157	0.060
kinetochore organization	GO:0051383	2	0.059
nucleoside phosphate catabolic process	GO:1901292	222	0.059
protein modification by small protein removal	GO:0070646	21	0.055
meiotic cell cycle process	GO:1903046	77	0.054
stress granule disassembly	GO:0035617	2	0.054
nuclear division	GO:0000280	158	0.053
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.053
dna metabolic process	GO:0006259	303	0.053
purine ribonucleotide catabolic process	GO:0009154	208	0.053
regulation of neuron differentiation	GO:0045664	281	0.050
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.049
ribonucleoside metabolic process	GO:0009119	245	0.049
negative regulation of neuron apoptotic process	GO:0043524	92	0.048
cell maturation	GO:0048469	127	0.047
microtubule based process	GO:0007017	236	0.047	Fly
ribosomal small subunit biogenesis	GO:0042274	4	0.045
purine ribonucleoside catabolic process	GO:0046130	205	0.044
cellular nitrogen compound catabolic process	GO:0044270	280	0.044
negative regulation of translation	GO:0017148	22	0.043
mrna transport	GO:0051028	13	0.043
nucleobase containing small molecule metabolic process	GO:0055086	352	0.043
mitotic spindle organization	GO:0007052	10	0.042	Fly
developmental maturation	GO:0021700	193	0.039
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.039
aromatic compound catabolic process	GO:0019439	286	0.039
regulation of neuron projection development	GO:0010975	169	0.039
organelle fission	GO:0048285	170	0.038
positive regulation of cell death	GO:0010942	224	0.038
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.037
nucleoside catabolic process	GO:0009164	206	0.036
endocytosis	GO:0006897	168	0.035
body morphogenesis	GO:0010171	45	0.035
nucleotide catabolic process	GO:0009166	217	0.035
nucleotide metabolic process	GO:0009117	332	0.035
oocyte development	GO:0048599	33	0.035
atp catabolic process	GO:0006200	55	0.035
oocyte differentiation	GO:0009994	35	0.034
regulation of neuron apoptotic process	GO:0043523	122	0.033
development of primary sexual characteristics	GO:0045137	143	0.033
spermatid differentiation	GO:0048515	115	0.032
regulation of cell cycle process	GO:0010564	160	0.032
axonogenesis	GO:0007409	274	0.031
spermatogenesis	GO:0007283	284	0.031
chromosome segregation	GO:0007059	48	0.031
dna repair	GO:0006281	107	0.031
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.031
purine nucleotide catabolic process	GO:0006195	211	0.031
negative regulation of protein metabolic process	GO:0051248	282	0.031
positive regulation of programmed cell death	GO:0043068	218	0.030
skeletal muscle organ development	GO:0060538	163	0.030
regulation of neuron death	GO:1901214	134	0.030
multi multicellular organism process	GO:0044706	109	0.030
regulation of protein complex assembly	GO:0043254	83	0.030
establishment of organelle localization	GO:0051656	122	0.030
microtubule cytoskeleton organization	GO:0000226	157	0.029	Fly
neuron death	GO:0070997	154	0.029
protein localization to nucleus	GO:0034504	121	0.029
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.028
regulation of meiotic cell cycle	GO:0051445	34	0.027
mitotic nuclear division	GO:0007067	48	0.027
regulation of chromosome organization	GO:0033044	83	0.027
methylation	GO:0032259	134	0.027
heterocycle catabolic process	GO:0046700	280	0.026
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.026
male gamete generation	GO:0048232	285	0.026
dna packaging	GO:0006323	30	0.025
apoptotic signaling pathway	GO:0097190	306	0.025
dendrite development	GO:0016358	115	0.025
purine ribonucleoside metabolic process	GO:0046128	241	0.025
centrosome organization	GO:0051297	26	0.024
compound eye development	GO:0048749	1	0.024
multicellular organismal reproductive behavior	GO:0033057	23	0.024
chromatin modification	GO:0016568	187	0.024
nucleic acid transport	GO:0050657	18	0.024
oocyte anterior posterior axis specification	GO:0007314	2	0.023
nucleoside triphosphate metabolic process	GO:0009141	230	0.023
cell growth	GO:0016049	130	0.023
placenta development	GO:0001890	140	0.023
actin cytoskeleton organization	GO:0030036	220	0.023
regulation of protein stability	GO:0031647	52	0.022
regulation of apoptotic signaling pathway	GO:2001233	197	0.022
oogenesis	GO:0048477	56	0.022
regulation of hydrolase activity	GO:0051336	246	0.021
positive regulation of transcription from rna polymerase i promoter	GO:0045943	3	0.021
carbohydrate derivative biosynthetic process	GO:1901137	183	0.020
positive regulation of apoptotic process	GO:0043065	217	0.020
forebrain development	GO:0030900	302	0.020
regulation of cellular component biogenesis	GO:0044087	181	0.020
nucleoside triphosphate catabolic process	GO:0009143	205	0.020
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.020
adult locomotory behavior	GO:0008344	91	0.020
purine containing compound metabolic process	GO:0072521	311	0.020
purine nucleoside metabolic process	GO:0042278	241	0.020
glycosyl compound metabolic process	GO:1901657	246	0.019
cellular protein complex assembly	GO:0043623	116	0.019
spindle localization	GO:0051653	22	0.018
regulation of mrna processing	GO:0050684	41	0.018
nucleoside phosphate metabolic process	GO:0006753	338	0.018
regulation of cell projection organization	GO:0031344	206	0.018
regulation of cell motility	GO:2000145	236	0.018
gliogenesis	GO:0042063	141	0.017
cellular amino acid metabolic process	GO:0006520	103	0.017
plus end directed vesicle transport along microtubule	GO:0072383	2	0.017
organic cyclic compound catabolic process	GO:1901361	295	0.017
response to interferon gamma	GO:0034341	34	0.017
cytoplasmic transport	GO:0016482	234	0.017
carbohydrate derivative catabolic process	GO:1901136	231	0.017
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.017
nuclear import	GO:0051170	95	0.016
mrna metabolic process	GO:0016071	84	0.016
positive regulation of peptidase activity	GO:0010952	49	0.016
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.016
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.016
ribonucleotide metabolic process	GO:0009259	291	0.016
negative regulation of neuron death	GO:1901215	98	0.016
ribose phosphate metabolic process	GO:0019693	291	0.016
ribonucleoside catabolic process	GO:0042454	206	0.016
lateral inhibition	GO:0046331	1	0.016
regulation of membrane potential	GO:0042391	192	0.015
rna transport	GO:0050658	18	0.015
cellular response to interferon gamma	GO:0071346	25	0.015
intracellular protein transport	GO:0006886	204	0.015
regulation of cell substrate adhesion	GO:0010810	73	0.015
mrna splicing via spliceosome	GO:0000398	43	0.015
lipid localization	GO:0010876	126	0.015
nucleoside metabolic process	GO:0009116	246	0.015
neuron projection extension	GO:1990138	64	0.015
mrna stabilization	GO:0048255	9	0.015
regulation of cellular amino acid metabolic process	GO:0006521	5	0.014
mitotic cell cycle process	GO:1903047	159	0.014	Fly
regulation of cell division	GO:0051302	76	0.014
meiotic cell cycle	GO:0051321	122	0.014
protein import into nucleus	GO:0006606	95	0.014
action potential	GO:0001508	78	0.014
cellular amine metabolic process	GO:0044106	44	0.014
germ cell proliferation	GO:0036093	7	0.014
establishment of rna localization	GO:0051236	18	0.014
myosin filament organization	GO:0031033	3	0.014
regulation of chromatin modification	GO:1903308	57	0.013
mesenchymal cell development	GO:0014031	93	0.013
muscle tissue development	GO:0060537	308	0.013
negative regulation of growth	GO:0045926	99	0.013
organelle disassembly	GO:1903008	2	0.013
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.013
receptor mediated endocytosis	GO:0006898	51	0.013
embryonic heart tube development	GO:0035050	65	0.013
regulation of rna splicing	GO:0043484	37	0.013
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.013
morphogenesis of a branching epithelium	GO:0061138	193	0.013
macromolecule catabolic process	GO:0009057	281	0.013
mitotic cell cycle	GO:0000278	195	0.013	Fly
developmental growth involved in morphogenesis	GO:0060560	138	0.012
intrinsic apoptotic signaling pathway	GO:0097193	132	0.012
regulation of circadian rhythm	GO:0042752	58	0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.012
cellular ketone metabolic process	GO:0042180	84	0.012
adult behavior	GO:0030534	135	0.012
rhythmic process	GO:0048511	174	0.012
protein targeting	GO:0006605	143	0.012
regulation of peptidase activity	GO:0052547	96	0.012
cell type specific apoptotic process	GO:0097285	268	0.012
gonad development	GO:0008406	141	0.012
hematopoietic progenitor cell differentiation	GO:0002244	143	0.012
determination of left right symmetry	GO:0007368	80	0.011
alternative mrna splicing via spliceosome	GO:0000380	12	0.011
response to organic cyclic compound	GO:0014070	198	0.011
visual perception	GO:0007601	52	0.011
endodermal digestive tract morphogenesis	GO:0061031	4	0.011
striated muscle myosin thick filament assembly	GO:0071688	1	0.011
positive regulation of nervous system development	GO:0051962	221	0.011
nitrogen compound transport	GO:0071705	271	0.011
regulation of mrna metabolic process	GO:1903311	43	0.011
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO:1902254	8	0.011
mesenchyme development	GO:0060485	152	0.011
regionalization	GO:0003002	337	0.011
ncrna processing	GO:0034470	26	0.011
rna localization	GO:0006403	23	0.011
positive regulation of potassium ion transport	GO:0043268	3	0.011
negative regulation of dna replication	GO:0008156	4	0.011
protein processing	GO:0016485	163	0.011
positive regulation of translational initiation	GO:0045948	4	0.011
glycosyl compound catabolic process	GO:1901658	206	0.011
endonucleolytic cleavage involved in rrna processing	GO:0000478	1	0.010
multicellular organismal aging	GO:0010259	24	0.010
protein localization to membrane	GO:0072657	108	0.010
epithelial tube morphogenesis	GO:0060562	303	0.010
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.010
striated muscle tissue development	GO:0014706	293	0.010
mrna catabolic process	GO:0006402	22	0.010
protein import	GO:0017038	101	0.010
establishment of spindle orientation	GO:0051294	15	0.010
purine containing compound catabolic process	GO:0072523	213	0.010

Eif3a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.245
disease of anatomical entity	DOID:7	0.245
central nervous system disease	DOID:331	0.095
neurodegenerative disease	DOID:1289	0.095

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