IMP: Integrative Multi-species Prediction

Mus musculus

173 known processes

Epas1

endothelial PAS domain protein 1

(Aliases: HIF2A,MOP2,bHLHe73,HLF,HIF-2alpha,HRF)

Entrez: 13819
Ensembl: ENSMUSG00000024140
UniProtKB: P97481

Process Predictions
Disease Predictions

Epas1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.977	Mouse
blood vessel morphogenesis	GO:0048514	285	0.958
4 hydroxyproline metabolic process	GO:0019471	5	0.948
heart trabecula formation	GO:0060347	14	0.947
respiratory system development	GO:0060541	190	0.930
angiogenesis	GO:0001525	201	0.899
regulation of neuron apoptotic process	GO:0043523	122	0.874	Zebrafish Mouse
muscle tissue development	GO:0060537	308	0.869
positive regulation of protein modification process	GO:0031401	299	0.844
mapk cascade	GO:0000165	281	0.844
peptidyl proline hydroxylation to 4 hydroxy l proline	GO:0018401	2	0.832
cardiac muscle tissue development	GO:0048738	130	0.818
cell type specific apoptotic process	GO:0097285	268	0.807	Zebrafish Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.774	Mouse
regulation of muscle system process	GO:0090257	80	0.773
homeostasis of number of cells	GO:0048872	210	0.768
regulation of protein kinase activity	GO:0045859	232	0.744
cellular amino acid metabolic process	GO:0006520	103	0.738
negative regulation of cell proliferation	GO:0008285	296	0.733
lung development	GO:0030324	164	0.721
cell growth	GO:0016049	130	0.694	Fly
gland development	GO:0048732	330	0.675	Mouse
physiological cardiac muscle hypertrophy	GO:0003301	3	0.669
blood circulation	GO:0008015	195	0.667
erythrocyte differentiation	GO:0030218	88	0.666
glycosyl compound catabolic process	GO:1901658	206	0.654
hormone secretion	GO:0046879	128	0.650	Mouse
alpha amino acid metabolic process	GO:1901605	59	0.649
regulation of hydrolase activity	GO:0051336	246	0.639
myeloid cell differentiation	GO:0030099	233	0.634
regulation of cellular amine metabolic process	GO:0033238	20	0.634
regulation of myeloid cell differentiation	GO:0045637	96	0.629	Mouse
peptidyl amino acid modification	GO:0018193	336	0.628
negative regulation of neuron death	GO:1901215	98	0.628	Mouse
striated muscle tissue development	GO:0014706	293	0.627
regulation of homeostatic process	GO:0032844	182	0.624	Mouse
regulation of kinase activity	GO:0043549	249	0.622
regulation of mapk cascade	GO:0043408	248	0.619
regulation of protein serine threonine kinase activity	GO:0071900	157	0.618
regulation of anatomical structure size	GO:0090066	178	0.618
organophosphate catabolic process	GO:0046434	232	0.614
embryonic placenta development	GO:0001892	98	0.591
response to decreased oxygen levels	GO:0036293	59	0.590
myeloid cell homeostasis	GO:0002262	114	0.588
neuron apoptotic process	GO:0051402	142	0.585	Zebrafish Mouse
regulation of heart contraction	GO:0008016	77	0.579
response to hypoxia	GO:0001666	58	0.572
circulatory system process	GO:0003013	197	0.569
regulation of cell activation	GO:0050865	289	0.567
nuclear transport	GO:0051169	139	0.556
positive regulation of nervous system development	GO:0051962	221	0.546	Mouse
muscle cell differentiation	GO:0042692	261	0.540
organonitrogen compound catabolic process	GO:1901565	264	0.537
regulation of angiogenesis	GO:0045765	81	0.533
purine nucleotide metabolic process	GO:0006163	302	0.532
stem cell differentiation	GO:0048863	268	0.522	Mouse
response to inactivity	GO:0014854	4	0.519
peptidyl proline hydroxylation	GO:0019511	3	0.518
bmp signaling pathway	GO:0030509	93	0.512
response to peptide	GO:1901652	136	0.512	Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.504
regulation of cell adhesion	GO:0030155	154	0.501
heart process	GO:0003015	94	0.499
purine containing compound metabolic process	GO:0072521	311	0.496
embryonic organ morphogenesis	GO:0048562	276	0.496	Mouse
oxygen homeostasis	GO:0032364	2	0.494	Mouse
regulation of bmp signaling pathway	GO:0030510	60	0.493
kidney development	GO:0001822	213	0.489	Mouse
cellular homeostasis	GO:0019725	240	0.487	Mouse
ameboidal type cell migration	GO:0001667	128	0.486	Mouse
metal ion homeostasis	GO:0055065	189	0.480
t cell activation	GO:0042110	289	0.479
ion transmembrane transport	GO:0034220	361	0.476
regulation of cell size	GO:0008361	72	0.475
epithelial cell migration	GO:0010631	63	0.472	Mouse
regulation of ossification	GO:0030278	112	0.463	Mouse
regulation of purine nucleotide metabolic process	GO:1900542	169	0.463
skeletal system development	GO:0001501	356	0.458	Mouse
vascular process in circulatory system	GO:0003018	62	0.456
nitrogen compound transport	GO:0071705	271	0.453	Mouse
digestive tract morphogenesis	GO:0048546	147	0.453	Mouse
connective tissue development	GO:0061448	179	0.453	Mouse
oxidation reduction process	GO:0055114	342	0.452
fat cell differentiation	GO:0045444	160	0.448
negative regulation of neuron apoptotic process	GO:0043524	92	0.443	Mouse
regulation of cell migration	GO:0030334	219	0.436	Mouse Fly
learning or memory	GO:0007611	148	0.431	Mouse
urogenital system development	GO:0001655	261	0.430	Mouse
regulation of cell growth	GO:0001558	91	0.427	Fly
cell growth involved in cardiac muscle cell development	GO:0061049	3	0.425
regulation of response to wounding	GO:1903034	189	0.418
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.414
regulation of nucleotide metabolic process	GO:0006140	169	0.412
heart contraction	GO:0060047	93	0.404
muscle adaptation	GO:0043500	39	0.403
cation transport	GO:0006812	399	0.403
monocarboxylic acid metabolic process	GO:0032787	191	0.394	Mouse
t cell differentiation	GO:0030217	174	0.394
peptide hormone secretion	GO:0030072	109	0.393	Mouse
response to insulin	GO:0032868	100	0.391	Fly
cellular modified amino acid metabolic process	GO:0006575	63	0.389
cellular response to organonitrogen compound	GO:0071417	145	0.382	Fly
regulation of vasculature development	GO:1901342	88	0.380
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.373	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.368
regulation of neuron death	GO:1901214	134	0.364	Zebrafish Mouse
positive regulation of growth	GO:0045927	104	0.364
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.363
metanephric glomerular mesangium development	GO:0072223	3	0.363
inorganic cation transmembrane transport	GO:0098662	207	0.359
regulation of erythrocyte differentiation	GO:0045646	23	0.357	Mouse
trachea development	GO:0060438	18	0.357	Fly
protein export from nucleus	GO:0006611	20	0.356
wound healing	GO:0042060	157	0.350	Mouse
embryonic heart tube development	GO:0035050	65	0.350	Mouse
purine ribonucleotide metabolic process	GO:0009150	290	0.345
inflammatory response	GO:0006954	244	0.344	Mouse
regulation of hormone levels	GO:0010817	211	0.343	Mouse
cell adhesion	GO:0007155	329	0.338
epithelial tube morphogenesis	GO:0060562	303	0.334	Mouse
purine ribonucleotide catabolic process	GO:0009154	208	0.331
digestive tract development	GO:0048565	190	0.328	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	352	0.326
nucleoside phosphate metabolic process	GO:0006753	338	0.324
regulation of transferase activity	GO:0051338	263	0.322
positive regulation of kinase activity	GO:0033674	155	0.321
nucleocytoplasmic transport	GO:0006913	139	0.320
aromatic compound catabolic process	GO:0019439	286	0.320
cytoplasmic transport	GO:0016482	234	0.319
regulation of hippo signaling	GO:0035330	1	0.315
cardiac chamber morphogenesis	GO:0003206	93	0.310	Mouse
glucocorticoid biosynthetic process	GO:0006704	5	0.308
positive regulation of behavior	GO:0048520	40	0.306
cytokine production	GO:0001816	319	0.304
regulation of receptor activity	GO:0010469	41	0.304
response to organic cyclic compound	GO:0014070	198	0.303
regulation of muscle contraction	GO:0006937	49	0.298
epithelium migration	GO:0090132	63	0.297	Mouse
ribose phosphate metabolic process	GO:0019693	291	0.296
neuron death	GO:0070997	154	0.296	Zebrafish Mouse
positive regulation of cell motility	GO:2000147	116	0.295	Mouse
developmental cell growth	GO:0048588	84	0.294
leukocyte differentiation	GO:0002521	342	0.284
regulation of system process	GO:0044057	200	0.284
blood vessel remodeling	GO:0001974	33	0.284
positive regulation of transferase activity	GO:0051347	167	0.282
regulation of t cell activation	GO:0050863	170	0.279
positive regulation of protein kinase activity	GO:0045860	144	0.278
alcohol metabolic process	GO:0006066	116	0.275
regulation of blood circulation	GO:1903522	93	0.274
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway	GO:0035793	1	0.273
intracellular protein transport	GO:0006886	204	0.272
labyrinthine layer development	GO:0060711	49	0.270
heart trabecula morphogenesis	GO:0061384	26	0.270
regulation of cellular ketone metabolic process	GO:0010565	66	0.268
muscle hypertrophy	GO:0014896	24	0.268
camera type eye development	GO:0043010	266	0.265	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.263
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.263
ribonucleotide metabolic process	GO:0009259	291	0.262
regulation of map kinase activity	GO:0043405	120	0.261
cellular response to insulin stimulus	GO:0032869	78	0.261	Fly
cardiac septum development	GO:0003279	59	0.260
sensory perception of mechanical stimulus	GO:0050954	107	0.258
regulation of lymphocyte differentiation	GO:0045619	107	0.258
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.254
positive regulation of ion transmembrane transporter activity	GO:0032414	15	0.252
regulation of neural precursor cell proliferation	GO:2000177	70	0.252	Mouse
epidermis development	GO:0008544	187	0.251
regulation of vascular endothelial growth factor receptor signaling pathway	GO:0030947	14	0.250	Mouse
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.250
chemotaxis	GO:0006935	247	0.250
ribonucleoside metabolic process	GO:0009119	245	0.248
regulation of epithelial cell migration	GO:0010632	35	0.248	Mouse
response to transforming growth factor beta	GO:0071559	88	0.246
development of primary sexual characteristics	GO:0045137	143	0.245
nucleotide catabolic process	GO:0009166	217	0.240
branching morphogenesis of an epithelial tube	GO:0048754	159	0.240
regulation of leukocyte differentiation	GO:1902105	159	0.239
bone development	GO:0060348	120	0.235
lymphocyte differentiation	GO:0030098	242	0.235
respiratory tube development	GO:0030323	167	0.234
regulation of mesenchymal cell proliferation	GO:0010464	37	0.233
morphogenesis of embryonic epithelium	GO:0016331	159	0.233	Mouse
calcium ion transport	GO:0006816	159	0.233
ventricular septum development	GO:0003281	42	0.230
regulation of cellular component size	GO:0032535	121	0.228
stem cell development	GO:0048864	219	0.228	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.227
trunk neural crest cell migration	GO:0036484	4	0.224
trabecula formation	GO:0060343	24	0.224
cell junction assembly	GO:0034329	52	0.224
male sex differentiation	GO:0046661	109	0.220
renal system process involved in regulation of blood volume	GO:0001977	4	0.220
g protein coupled receptor signaling pathway	GO:0007186	243	0.220
purine containing compound catabolic process	GO:0072523	213	0.219
positive regulation of cell growth	GO:0030307	33	0.218
regulation of cellular amino acid metabolic process	GO:0006521	5	0.218
cardiac septum morphogenesis	GO:0060411	46	0.217
cellular response to erythropoietin	GO:0036018	1	0.217
trabecula morphogenesis	GO:0061383	40	0.217
carbohydrate derivative catabolic process	GO:1901136	231	0.216
negative regulation of phosphorus metabolic process	GO:0010563	184	0.215
morphogenesis of a branching structure	GO:0001763	203	0.214
positive regulation of chemotaxis	GO:0050921	38	0.214
t cell differentiation in thymus	GO:0033077	77	0.214
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.212
developmental growth involved in morphogenesis	GO:0060560	138	0.212
regulation of ras gtpase activity	GO:0032318	88	0.212
regulation of lymphocyte activation	GO:0051249	240	0.211
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.211
peptide secretion	GO:0002790	114	0.211	Mouse
regulation of endothelial cell migration	GO:0010594	22	0.210
glucose homeostasis	GO:0042593	128	0.210	Mouse
ossification	GO:0001503	216	0.208	Mouse
erythropoietin mediated signaling pathway	GO:0038162	1	0.208
regulation of transmembrane transport	GO:0034762	128	0.208
regulation of cellular response to hypoxia	GO:1900037	2	0.207
cardiac muscle contraction	GO:0060048	32	0.207
multicellular organism growth	GO:0035264	161	0.207
placenta development	GO:0001890	140	0.205
response to radiation	GO:0009314	165	0.203	Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.203
response to corticosterone	GO:0051412	1	0.200
blood coagulation	GO:0007596	76	0.200
response to erythropoietin	GO:0036017	1	0.199
gonadotrophin releasing hormone neuronal migration to the hypothalamus	GO:0021828	3	0.199
regulation of membrane potential	GO:0042391	192	0.199
cardiac muscle tissue morphogenesis	GO:0055008	44	0.198
cardiac muscle cell contraction	GO:0086003	7	0.196
metanephric glomerular mesangial cell proliferation involved in metanephros development	GO:0072262	3	0.196
positive regulation of epithelial cell migration	GO:0010634	19	0.195	Mouse
bone mineralization	GO:0030282	54	0.195	Mouse
lung alveolus development	GO:0048286	45	0.193
regulation of epithelial cell proliferation	GO:0050678	141	0.192
neuron projection extension involved in neuron projection guidance	GO:1902284	14	0.191
steroid metabolic process	GO:0008202	119	0.191
cellular ketone metabolic process	GO:0042180	84	0.189
response to inorganic substance	GO:0010035	96	0.189
negative regulation of growth	GO:0045926	99	0.188	Mouse Fly
vegf activated neuropilin signaling pathway	GO:0038190	2	0.187
skeletal system morphogenesis	GO:0048705	203	0.186
response to growth factor	GO:0070848	198	0.186	Mouse
platelet derived growth factor receptor beta signaling pathway	GO:0035791	4	0.186
sympathetic neuron projection guidance	GO:0097491	4	0.185
lipid biosynthetic process	GO:0008610	179	0.184
memory	GO:0007613	58	0.182
nuclear export	GO:0051168	34	0.181
response to oxygen levels	GO:0070482	62	0.179
cardiac chamber development	GO:0003205	108	0.179	Mouse
telencephalon development	GO:0021537	186	0.175	Mouse
positive regulation of cell migration	GO:0030335	109	0.174	Mouse
hair follicle development	GO:0001942	85	0.174
tissue migration	GO:0090130	68	0.174	Mouse
positive regulation of cell development	GO:0010720	237	0.174	Mouse
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.171
cellular chemical homeostasis	GO:0055082	215	0.167	Mouse
regulation of hormone secretion	GO:0046883	88	0.166	Mouse
heterocycle catabolic process	GO:0046700	280	0.166
positive regulation of mesenchymal cell proliferation	GO:0002053	33	0.165
extracellular matrix organization	GO:0030198	147	0.164
ribonucleotide catabolic process	GO:0009261	208	0.164
cytokine mediated signaling pathway	GO:0019221	115	0.163
microtubule based process	GO:0007017	236	0.163
skeletal muscle organ development	GO:0060538	163	0.162
multi multicellular organism process	GO:0044706	109	0.162	Mouse
regulation of ion transport	GO:0043269	215	0.161
axon guidance	GO:0007411	141	0.161
ventricular cardiac muscle cell action potential	GO:0086005	4	0.161
hypoxia inducible factor 1alpha signaling pathway	GO:0097411	2	0.160	Mouse
regulation of chemotaxis	GO:0050920	53	0.160
positive regulation of angiogenesis	GO:0045766	46	0.159
regulation of calcium ion transmembrane transporter activity	GO:1901019	20	0.159
synaptic transmission	GO:0007268	329	0.157
negative regulation of cell fate specification	GO:0009996	4	0.157
response to peptide hormone	GO:0043434	127	0.157	Fly
cardiac ventricle development	GO:0003231	83	0.155	Mouse
positive regulation of leukocyte differentiation	GO:1902107	86	0.155
regulation of ion transmembrane transport	GO:0034765	119	0.155
heart morphogenesis	GO:0003007	178	0.155	Mouse
negative regulation of protein metabolic process	GO:0051248	282	0.154
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.154	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.153
muscle contraction	GO:0006936	101	0.152
myeloid leukocyte differentiation	GO:0002573	119	0.152
cation homeostasis	GO:0055080	212	0.152
neural fold elevation formation	GO:0021502	1	0.152	Mouse
amine metabolic process	GO:0009308	45	0.151
male gonad development	GO:0008584	88	0.150
neural tube formation	GO:0001841	108	0.150	Mouse
regulation of transcription from rna polymerase ii promoter in response to hypoxia	GO:0061418	2	0.149
organ growth	GO:0035265	117	0.149
nucleotide metabolic process	GO:0009117	332	0.149
brown fat cell differentiation	GO:0050873	36	0.148
neural crest cell migration	GO:0001755	32	0.148	Mouse
positive regulation of cell activation	GO:0050867	158	0.147
regulation of cell projection assembly	GO:0060491	38	0.147
hippo signaling	GO:0035329	11	0.146
negative regulation of phosphate metabolic process	GO:0045936	184	0.145
positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:0030949	5	0.145	Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.144
associative learning	GO:0008306	61	0.142	Mouse
establishment of protein localization to organelle	GO:0072594	118	0.142
lung morphogenesis	GO:0060425	50	0.142
regulation of cardiac muscle contraction	GO:0055117	21	0.142
glycerolipid metabolic process	GO:0046486	122	0.142
leukocyte proliferation	GO:0070661	172	0.140
forebrain generation of neurons	GO:0021872	63	0.140
epithelial cell proliferation	GO:0050673	174	0.140
regulation of cellular component biogenesis	GO:0044087	181	0.139
negative regulation of hydrolase activity	GO:0051346	71	0.139
regulation of striated muscle cell differentiation	GO:0051153	81	0.139
positive regulation of apoptotic process	GO:0043065	217	0.139
negative regulation of epithelial cell proliferation	GO:0050680	64	0.139
positive regulation of nucleotide catabolic process	GO:0030813	88	0.139
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	8	0.138
embryonic hemopoiesis	GO:0035162	23	0.138	Mouse
cellular calcium ion homeostasis	GO:0006874	119	0.138
positive regulation of glial cell proliferation	GO:0060252	4	0.138
coagulation	GO:0050817	78	0.138
single organismal cell cell adhesion	GO:0016337	131	0.137
regulation of reproductive process	GO:2000241	66	0.137
regulation of cardiac cell fate specification	GO:2000043	1	0.136
purine nucleoside metabolic process	GO:0042278	241	0.136
spermatogenesis	GO:0007283	284	0.135
regulation of cell projection organization	GO:0031344	206	0.135
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.134
negative regulation of immune system process	GO:0002683	209	0.133
tissue remodeling	GO:0048771	102	0.133
purine ribonucleoside catabolic process	GO:0046130	205	0.132
regulation of glutamate secretion	GO:0014048	3	0.132
regulation of circadian sleep wake cycle sleep	GO:0045187	3	0.132
hemostasis	GO:0007599	78	0.131
sensory perception of sound	GO:0007605	97	0.131
leukocyte mediated immunity	GO:0002443	174	0.131
regulation of wound healing	GO:0061041	40	0.130
extracellular structure organization	GO:0043062	148	0.130
regulation of cell motility	GO:2000145	236	0.129	Mouse Fly
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.129
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.129
determination of left right symmetry	GO:0007368	80	0.129	Mouse
inner ear morphogenesis	GO:0042472	101	0.128
regulation of cell growth involved in cardiac muscle cell development	GO:0061050	3	0.127
diencephalon development	GO:0021536	63	0.127
trachea morphogenesis	GO:0060439	8	0.127
negative regulation of protein phosphorylation	GO:0001933	126	0.127
response to reactive oxygen species	GO:0000302	56	0.127
developmental maturation	GO:0021700	193	0.127
positive regulation of bmp signaling pathway	GO:0030513	23	0.126
positive regulation of smooth muscle cell migration	GO:0014911	4	0.126
muscle system process	GO:0003012	141	0.126
cellular response to lipid	GO:0071396	145	0.125
cellular response to monosaccharide stimulus	GO:0071326	47	0.125	Mouse
sensory organ morphogenesis	GO:0090596	242	0.125
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.125
response to oxidative stress	GO:0006979	123	0.125
negative regulation of cell growth	GO:0030308	44	0.124	Fly
molting cycle	GO:0042303	90	0.124
gliogenesis	GO:0042063	141	0.123
regulation of nucleoside metabolic process	GO:0009118	130	0.123
purine nucleotide catabolic process	GO:0006195	211	0.123
regulation of purine nucleotide catabolic process	GO:0033121	122	0.122
positive regulation of lymphocyte activation	GO:0051251	140	0.121
outflow tract morphogenesis	GO:0003151	53	0.121	Mouse
axonogenesis	GO:0007409	274	0.120
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.120
microtubule based movement	GO:0007018	84	0.119
response to organonitrogen compound	GO:0010243	246	0.118	Fly
tissue homeostasis	GO:0001894	115	0.118
drug catabolic process	GO:0042737	2	0.118
muscle tissue morphogenesis	GO:0060415	53	0.118
response to mineralocorticoid	GO:0051385	1	0.118
nucleoside triphosphate catabolic process	GO:0009143	205	0.118
regulation of calcium ion transmembrane transport	GO:1903169	20	0.118
apoptotic signaling pathway	GO:0097190	306	0.117
nucleoside catabolic process	GO:0009164	206	0.117
sensory perception	GO:0007600	245	0.117
lymphocyte proliferation	GO:0046651	164	0.117
appendage morphogenesis	GO:0035107	149	0.117
regulation of metanephric mesenchymal cell migration	GO:2000589	2	0.116
fatty acid metabolic process	GO:0006631	121	0.116
regulation of lipid metabolic process	GO:0019216	118	0.115
cell maturation	GO:0048469	127	0.114
regulation of blood pressure	GO:0008217	93	0.114
amide transport	GO:0042886	138	0.113	Mouse
gonad development	GO:0008406	141	0.113
regulation of vesicle mediated transport	GO:0060627	139	0.113
sympathetic neuron projection extension	GO:0097490	4	0.113
ventral trunk neural crest cell migration	GO:0036486	4	0.111
ribonucleotide biosynthetic process	GO:0009260	59	0.111
osteoclast differentiation	GO:0030316	62	0.110
embryonic epithelial tube formation	GO:0001838	130	0.109	Mouse
facioacoustic ganglion development	GO:1903375	3	0.109
positive regulation of ion transport	GO:0043270	65	0.107
regulation of protein stability	GO:0031647	52	0.107
regulation of tube size	GO:0035150	57	0.107
regulation of cellular response to stress	GO:0080135	159	0.107
negative regulation of cell development	GO:0010721	169	0.107
negative regulation of nervous system development	GO:0051961	156	0.107
biomineral tissue development	GO:0031214	64	0.106	Mouse
embryonic skeletal system development	GO:0048706	120	0.106
cellular response to cytokine stimulus	GO:0071345	189	0.106
negative regulation of cellular component organization	GO:0051129	194	0.105
muscle cell proliferation	GO:0033002	52	0.105
vasodilation	GO:0042311	28	0.105
b cell activation	GO:0042113	161	0.104
regulation of striated muscle contraction	GO:0006942	25	0.104
regulation of secretion	GO:0051046	274	0.103	Mouse
hormone metabolic process	GO:0042445	86	0.103
glycosyl compound metabolic process	GO:1901657	246	0.102
neuroepithelial cell differentiation	GO:0060563	37	0.102
striated muscle hypertrophy	GO:0014897	24	0.102
regulation of organelle organization	GO:0033043	289	0.101
regulation of nucleotide catabolic process	GO:0030811	122	0.101
cardiac muscle hypertrophy	GO:0003300	23	0.101
ureteric bud development	GO:0001657	94	0.101	Mouse
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.101
striated muscle cell development	GO:0055002	125	0.101
positive regulation of metanephric mesenchymal cell migration	GO:2000591	1	0.100
cerebral cortex development	GO:0021987	86	0.100	Mouse
lung epithelial cell differentiation	GO:0060487	29	0.100
carbohydrate metabolic process	GO:0005975	230	0.100	Mouse
immune effector process	GO:0002252	321	0.100
regulation of ras protein signal transduction	GO:0046578	114	0.100
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.100
negative regulation of bmp signaling pathway	GO:0030514	35	0.099
response to monosaccharide	GO:0034284	67	0.099	Mouse
stem cell maintenance	GO:0019827	130	0.099
regulation of leukocyte apoptotic process	GO:2000106	56	0.099	Mouse
gtp metabolic process	GO:0046039	144	0.099
glucose transport	GO:0015758	56	0.098
divalent inorganic cation homeostasis	GO:0072507	138	0.097
hepaticobiliary system development	GO:0061008	67	0.096
nucleoside phosphate catabolic process	GO:1901292	222	0.096
canonical wnt signaling pathway	GO:0060070	130	0.096
positive regulation of cellular amine metabolic process	GO:0033240	5	0.095
metanephric glomerular endothelium development	GO:0072264	1	0.095
embryonic camera type eye development	GO:0031076	36	0.095
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.095
limb development	GO:0060173	166	0.095
posttranscriptional regulation of gene expression	GO:0010608	155	0.095
chondrocyte hypertrophy	GO:0003415	4	0.095
protein maturation	GO:0051604	176	0.094
regulation of smad protein import into nucleus	GO:0060390	3	0.094
energy derivation by oxidation of organic compounds	GO:0015980	77	0.094
development of primary male sexual characteristics	GO:0046546	88	0.094
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.094
odontogenesis of dentin containing tooth	GO:0042475	66	0.094
positive regulation of neural precursor cell proliferation	GO:2000179	42	0.093	Mouse
b cell proliferation	GO:0042100	53	0.093
cellular response to lipopolysaccharide	GO:0071222	77	0.093
divalent inorganic cation transport	GO:0072511	178	0.093
neuron projection guidance	GO:0097485	141	0.093
hypothalamus gonadotrophin releasing hormone neuron development	GO:0021888	4	0.092
cellular response to peptide	GO:1901653	92	0.092	Fly
carbohydrate derivative biosynthetic process	GO:1901137	183	0.092
physiological muscle hypertrophy	GO:0003298	3	0.092
endothelial cell migration	GO:0043542	44	0.092
mitotic cell cycle process	GO:1903047	159	0.092
lung cell differentiation	GO:0060479	30	0.091
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway	GO:1900238	1	0.091
positive regulation of t cell activation	GO:0050870	101	0.091
endocrine system development	GO:0035270	98	0.090
regulation of glucocorticoid biosynthetic process	GO:0031946	2	0.090
guanosine containing compound metabolic process	GO:1901068	144	0.090
negative regulation of wnt signaling pathway involved in heart development	GO:0003308	4	0.089
kidney epithelium development	GO:0072073	121	0.089	Mouse
positive regulation of amino acid transport	GO:0051957	4	0.089
brain morphogenesis	GO:0048854	32	0.089
neuron projection extension	GO:1990138	64	0.089
extrinsic apoptotic signaling pathway	GO:0097191	126	0.088
negative regulation of wnt signaling pathway	GO:0030178	73	0.088
nephron epithelium development	GO:0072009	92	0.088
response to epidermal growth factor	GO:0070849	4	0.088
cyclic nucleotide metabolic process	GO:0009187	59	0.088
neuron migration	GO:0001764	122	0.088
regulation of glomerular filtration	GO:0003093	3	0.088
regulation of the force of heart contraction	GO:0002026	17	0.088
peptide transport	GO:0015833	133	0.087	Mouse
metanephric mesenchymal cell migration	GO:0035789	2	0.087
forebrain neuron differentiation	GO:0021879	52	0.087
septum primum development	GO:0003284	4	0.087
endothelial cell differentiation	GO:0045446	41	0.087
branchiomotor neuron axon guidance	GO:0021785	7	0.087
cellular ion homeostasis	GO:0006873	165	0.087	Mouse
cartilage development	GO:0051216	140	0.086	Mouse
regulation of sodium ion transport	GO:0002028	29	0.085
positive regulation of phosphatidylinositol 3 kinase signaling	GO:0014068	20	0.085
bone morphogenesis	GO:0060349	78	0.085
single organism nuclear import	GO:1902593	95	0.085
ovarian follicle development	GO:0001541	40	0.084
regulation of bone mineralization	GO:0030500	31	0.083	Mouse

Epas1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
kidney cancer	DOID:263	0.386
urinary system cancer	DOID:3996	0.386
renal cell carcinoma	DOID:4450	0.386
renal carcinoma	DOID:4451	0.386
cancer	DOID:162	0.386
disease of cellular proliferation	DOID:14566	0.386
organ system cancer	DOID:0050686	0.386

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