IMP: Integrative Multi-species Prediction

Mus musculus

187 known processes

Heyl

hairy/enhancer-of-split related with YRPW motif-like

(Aliases: Hrt3,hesr3,Hey3,bHLHb33)

Entrez: 56198
Ensembl: ENSMUSG00000032744
UniProtKB: Q9DBX7

Process Predictions
Disease Predictions

Heyl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
muscle system process	GO:0003012	141	0.488	Mouse
muscle cell differentiation	GO:0042692	261	0.455	Mouse
ear development	GO:0043583	200	0.378	Mouse
ventricular trabecula myocardium morphogenesis	GO:0003222	11	0.376	Mouse
arterial endothelial cell differentiation	GO:0060842	5	0.198	Mouse
positive regulation of nervous system development	GO:0051962	221	0.175
stem cell differentiation	GO:0048863	268	0.162
nephron epithelium morphogenesis	GO:0072088	68	0.159	Mouse
regulation of auditory receptor cell differentiation	GO:0045607	4	0.158	Mouse
renal tubule morphogenesis	GO:0061333	72	0.157	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.153
renal system development	GO:0072001	225	0.136
cardiac muscle cell development	GO:0055013	39	0.134	Mouse
nephron development	GO:0072006	109	0.134
muscular septum morphogenesis	GO:0003150	4	0.131	Mouse
cell fate commitment	GO:0045165	210	0.130	Mouse Fly
regulation of striated muscle cell differentiation	GO:0051153	81	0.128
blood vessel morphogenesis	GO:0048514	285	0.123	Mouse
cardiocyte differentiation	GO:0035051	87	0.122	Mouse
skeletal muscle organ development	GO:0060538	163	0.120
cell adhesion	GO:0007155	329	0.119
heart trabecula morphogenesis	GO:0061384	26	0.117	Mouse
response to organonitrogen compound	GO:0010243	246	0.114
muscle cell development	GO:0055001	133	0.108	Mouse
striated muscle tissue development	GO:0014706	293	0.106
muscle tissue development	GO:0060537	308	0.104
extracellular structure organization	GO:0043062	148	0.103
regulation of heart growth	GO:0060420	31	0.100	Mouse
organ growth	GO:0035265	117	0.098	Mouse
regulation of cardiac muscle tissue development	GO:0055024	31	0.098	Mouse
regulation of cardiac muscle cell proliferation	GO:0060043	23	0.095	Mouse
ras protein signal transduction	GO:0007265	77	0.095
cellular response to growth factor stimulus	GO:0071363	197	0.090
camp biosynthetic process	GO:0006171	31	0.087
cardiac chamber development	GO:0003205	108	0.087
hematopoietic progenitor cell differentiation	GO:0002244	143	0.085
cardiac ventricle development	GO:0003231	83	0.084
cardiac muscle cell proliferation	GO:0060038	31	0.084	Mouse
cardiac muscle tissue development	GO:0048738	130	0.081	Mouse
regulation of neuron projection development	GO:0010975	169	0.080
muscle contraction	GO:0006936	101	0.080
purine nucleotide metabolic process	GO:0006163	302	0.079
cardiac cell development	GO:0055006	41	0.078	Mouse
negative regulation of cell development	GO:0010721	169	0.077	Mouse
endothelium development	GO:0003158	45	0.075	Mouse
skeletal muscle cell differentiation	GO:0035914	66	0.071
single organismal cell cell adhesion	GO:0016337	131	0.071
kidney epithelium development	GO:0072073	121	0.071
endothelial cell differentiation	GO:0045446	41	0.071	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.071
development of primary sexual characteristics	GO:0045137	143	0.071
cardiac right ventricle formation	GO:0003219	3	0.070
forebrain development	GO:0030900	302	0.070
organelle assembly	GO:0070925	177	0.070
stem cell development	GO:0048864	219	0.069
regulation of cardiac muscle tissue growth	GO:0055021	26	0.069	Mouse
negative regulation of neuron differentiation	GO:0045665	101	0.067	Mouse
striated muscle cell development	GO:0055002	125	0.066	Mouse
epithelial to mesenchymal transition involved in endocardial cushion formation	GO:0003198	10	0.065
kidney development	GO:0001822	213	0.065
purine nucleotide biosynthetic process	GO:0006164	65	0.065
cardiac septum morphogenesis	GO:0060411	46	0.063
angiogenesis	GO:0001525	201	0.063
artery development	GO:0060840	53	0.063	Mouse
regulation of muscle system process	GO:0090257	80	0.062
cell substrate adhesion	GO:0031589	130	0.061
cellular response to organonitrogen compound	GO:0071417	145	0.061
ossification	GO:0001503	216	0.060	Mouse
striated muscle cell proliferation	GO:0014855	39	0.060	Mouse
regulation of epidermal cell differentiation	GO:0045604	21	0.060	Mouse
positive regulation of striated muscle tissue development	GO:0045844	31	0.060	Mouse
regulation of ossification	GO:0030278	112	0.059	Mouse
renal tubule development	GO:0061326	87	0.059
regulation of purine nucleotide metabolic process	GO:1900542	169	0.059
mechanoreceptor differentiation	GO:0042490	67	0.058	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.057
trabecula morphogenesis	GO:0061383	40	0.056	Mouse
positive regulation of muscle tissue development	GO:1901863	32	0.056	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.056
lateral inhibition	GO:0046331	1	0.056
digestive system development	GO:0055123	200	0.056
respiratory system development	GO:0060541	190	0.054
positive regulation of cardiac muscle cell proliferation	GO:0060045	15	0.054	Mouse
synapse organization	GO:0050808	125	0.053
regulation of cellular component biogenesis	GO:0044087	181	0.053
cardiac muscle tissue growth	GO:0055017	37	0.053	Mouse
regulation of neuron differentiation	GO:0045664	281	0.053
lymphocyte proliferation	GO:0046651	164	0.052
nephron morphogenesis	GO:0072028	69	0.052	Mouse
embryonic placenta development	GO:0001892	98	0.052	Mouse
inner ear morphogenesis	GO:0042472	101	0.052
response to growth factor	GO:0070848	198	0.051
cardiac muscle cell differentiation	GO:0055007	69	0.051	Mouse
regulation of blood circulation	GO:1903522	93	0.051	Mouse
axonogenesis	GO:0007409	274	0.051
positive regulation of growth	GO:0045927	104	0.051	Mouse
nephron tubule development	GO:0072080	84	0.050
cell matrix adhesion	GO:0007160	68	0.050
branching morphogenesis of an epithelial tube	GO:0048754	159	0.050
glomerulus development	GO:0032835	40	0.049
purine ribonucleotide metabolic process	GO:0009150	290	0.049
purine containing compound biosynthetic process	GO:0072522	70	0.049
cellular amino acid metabolic process	GO:0006520	103	0.048
cellular response to external stimulus	GO:0071496	88	0.048
extracellular matrix organization	GO:0030198	147	0.048
neuroepithelial cell differentiation	GO:0060563	37	0.047
heart morphogenesis	GO:0003007	178	0.047
muscle adaptation	GO:0043500	39	0.046	Mouse
vascular smooth muscle cell differentiation	GO:0035886	11	0.046	Mouse
placenta development	GO:0001890	140	0.045	Mouse
regulation of system process	GO:0044057	200	0.045	Mouse
epidermis development	GO:0008544	187	0.045	Mouse
muscle tissue morphogenesis	GO:0060415	53	0.045	Mouse
neuron migration	GO:0001764	122	0.045
myeloid cell differentiation	GO:0030099	233	0.044
endocytosis	GO:0006897	168	0.044
regulation of wnt signaling pathway	GO:0030111	123	0.044
nucleoside phosphate biosynthetic process	GO:1901293	79	0.044
negative regulation of angiogenesis	GO:0016525	25	0.044
actin cytoskeleton organization	GO:0030036	220	0.044
nucleoside phosphate metabolic process	GO:0006753	338	0.044
single organism cell adhesion	GO:0098602	156	0.043
circadian rhythm	GO:0007623	114	0.043
regulation of heart rate	GO:0002027	36	0.043	Mouse
response to bmp	GO:0071772	14	0.043
recognition of apoptotic cell	GO:0043654	3	0.043
positive regulation of heart rate	GO:0010460	10	0.043	Mouse
heart trabecula formation	GO:0060347	14	0.042	Mouse
regulation of epidermis development	GO:0045682	33	0.042	Mouse
gonad development	GO:0008406	141	0.042
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.041	Mouse
ion transmembrane transport	GO:0034220	361	0.041
cellular ketone metabolic process	GO:0042180	84	0.041
nucleotide biosynthetic process	GO:0009165	78	0.040
regulation of osteoblast differentiation	GO:0045667	67	0.040	Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.040
ribonucleotide metabolic process	GO:0009259	291	0.040
protein oligomerization	GO:0051259	67	0.039
formation of organ boundary	GO:0010160	1	0.039
retina development in camera type eye	GO:0060041	119	0.039
negative regulation of cellular component organization	GO:0051129	194	0.039
palate development	GO:0060021	76	0.039
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.039
bone development	GO:0060348	120	0.039
cell growth involved in cardiac muscle cell development	GO:0061049	3	0.039
urogenital system development	GO:0001655	261	0.038
mesonephric tubule morphogenesis	GO:0072171	63	0.038	Mouse
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.038
cell fate determination	GO:0001709	32	0.038	Fly
mesenchyme development	GO:0060485	152	0.037
epithelial tube morphogenesis	GO:0060562	303	0.037	Mouse
regulation of protein localization	GO:0032880	231	0.037
compound eye development	GO:0048749	1	0.037
carbohydrate derivative biosynthetic process	GO:1901137	183	0.036
regulation of cell projection organization	GO:0031344	206	0.036
ureteric bud morphogenesis	GO:0060675	62	0.036	Mouse
wound healing	GO:0042060	157	0.035
regulation of heart contraction	GO:0008016	77	0.035	Mouse
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.035
mesenchymal cell differentiation	GO:0048762	107	0.035
g protein coupled receptor signaling pathway	GO:0007186	243	0.035
cellular response to bmp stimulus	GO:0071773	14	0.035
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.035
negative regulation of striated muscle cell differentiation	GO:0051154	14	0.034
myeloid leukocyte differentiation	GO:0002573	119	0.034
positive regulation of neuron projection development	GO:0010976	79	0.034
positive regulation of cardiac muscle tissue growth	GO:0055023	15	0.034	Mouse
skeletal system development	GO:0001501	356	0.034
aromatic compound catabolic process	GO:0019439	286	0.034
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation	GO:2000721	2	0.034
physiological cardiac muscle hypertrophy	GO:0003301	3	0.033
organonitrogen compound biosynthetic process	GO:1901566	192	0.033
calcium ion transport	GO:0006816	159	0.033
regulation of nucleotide metabolic process	GO:0006140	169	0.033
plasma membrane organization	GO:0007009	90	0.032
inner ear receptor cell differentiation	GO:0060113	61	0.032	Mouse
cellular response to acid chemical	GO:0071229	68	0.032
central nervous system neuron differentiation	GO:0021953	162	0.032
exocrine system development	GO:0035272	45	0.032
regulation of cardiac muscle cell apoptotic process	GO:0010665	9	0.032	Mouse
negative regulation of synapse maturation	GO:2000297	2	0.032
lung development	GO:0030324	164	0.032
multicellular organism growth	GO:0035264	161	0.032	Mouse
divalent metal ion transport	GO:0070838	172	0.032
regulation of cell motility	GO:2000145	236	0.032
regulation of cytoplasmic transport	GO:1903649	112	0.032
cardiac septum development	GO:0003279	59	0.031
morphogenesis of an epithelial sheet	GO:0002011	27	0.031
apoptotic signaling pathway	GO:0097190	306	0.031
regulation of leukocyte differentiation	GO:1902105	159	0.031
negative regulation of synapse assembly	GO:0051964	3	0.031
rac protein signal transduction	GO:0016601	13	0.031
negative regulation of endothelial cell migration	GO:0010596	4	0.030
mesenchymal cell development	GO:0014031	93	0.030
positive regulation of cell migration	GO:0030335	109	0.030
cardiac vascular smooth muscle cell development	GO:0060948	3	0.030	Mouse
oxidation reduction process	GO:0055114	342	0.030
positive regulation of wnt signaling pathway	GO:0030177	45	0.030
neuron fate determination	GO:0048664	9	0.030	Fly
regulation of fibroblast growth factor production	GO:0090270	4	0.030
protein targeting	GO:0006605	143	0.030
nucleobase containing small molecule metabolic process	GO:0055086	352	0.030
second messenger mediated signaling	GO:0019932	73	0.030
cardiac muscle tissue morphogenesis	GO:0055008	44	0.029	Mouse
cardiac chamber morphogenesis	GO:0003206	93	0.029
cochlea development	GO:0090102	35	0.029	Mouse
regulation of cell adhesion	GO:0030155	154	0.029
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.029
smooth muscle contraction	GO:0006939	44	0.029
heart contraction	GO:0060047	93	0.029	Mouse
non canonical wnt signaling pathway via jnk cascade	GO:0038031	3	0.029
mesonephros development	GO:0001823	97	0.029	Mouse
positive regulation of cell development	GO:0010720	237	0.029
skin development	GO:0043588	220	0.029	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.029
macromolecule catabolic process	GO:0009057	281	0.029
oviduct development	GO:0060066	3	0.029
regulation of cellular amino acid metabolic process	GO:0006521	5	0.028
cyclic purine nucleotide metabolic process	GO:0052652	43	0.028
endomembrane system organization	GO:0010256	147	0.028
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.028
osteoblast development	GO:0002076	17	0.028	Mouse
segmentation	GO:0035282	93	0.028
skeletal system morphogenesis	GO:0048705	203	0.028
vagus nerve development	GO:0021564	3	0.028
purine containing compound metabolic process	GO:0072521	311	0.028
sensory perception	GO:0007600	245	0.027
protein dna complex subunit organization	GO:0071824	28	0.027	Mouse
nucleotide metabolic process	GO:0009117	332	0.027
positive regulation of proteolysis	GO:0045862	85	0.027
regulation of protein transport	GO:0051223	163	0.027
sensory organ morphogenesis	GO:0090596	242	0.027
regulation of vasculature development	GO:1901342	88	0.027	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.026
ribonucleotide biosynthetic process	GO:0009260	59	0.026
respiratory tube development	GO:0030323	167	0.026
cyclic nucleotide biosynthetic process	GO:0009190	44	0.026
organophosphate biosynthetic process	GO:0090407	122	0.026
positive regulation of nucleotide metabolic process	GO:0045981	114	0.026
endocrine system development	GO:0035270	98	0.026
ventricular septum development	GO:0003281	42	0.026
positive regulation of canonical wnt signaling pathway	GO:0090263	29	0.026
regulation of neural precursor cell proliferation	GO:2000177	70	0.026
platelet morphogenesis	GO:0036344	13	0.026
intracellular protein transport	GO:0006886	204	0.026
astrocyte fate commitment	GO:0060018	4	0.026
regulation of cellular amine metabolic process	GO:0033238	20	0.026
spermatogenesis	GO:0007283	284	0.026
regulation of purine nucleotide catabolic process	GO:0033121	122	0.026
positive regulation of cellular amine metabolic process	GO:0033240	5	0.025
positive regulation of protein modification process	GO:0031401	299	0.025
non canonical wnt signaling pathway via mapk cascade	GO:0038030	3	0.025
positive regulation of ossification	GO:0045778	47	0.025	Mouse
tricuspid valve development	GO:0003175	3	0.025	Mouse
regulation of ras gtpase activity	GO:0032318	88	0.024
somite development	GO:0061053	81	0.024
positive regulation of homeostatic process	GO:0032846	64	0.024
ear morphogenesis	GO:0042471	118	0.024
connective tissue development	GO:0061448	179	0.024
regionalization	GO:0003002	337	0.024	Mouse
positive regulation of secretion by cell	GO:1903532	114	0.024
positive regulation of protein transport	GO:0051222	93	0.024
negative regulation of striated muscle cell apoptotic process	GO:0010664	8	0.024	Mouse
mapk cascade	GO:0000165	281	0.024
regulation of cell growth involved in cardiac muscle cell development	GO:0061050	3	0.023
regulation of cell migration	GO:0030334	219	0.023
regulation of myotube differentiation	GO:0010830	62	0.023
regulation of canonical wnt signaling pathway	GO:0060828	82	0.023
notch signaling pathway	GO:0007219	71	0.023	Human Mouse
renal outer medulla development	GO:0072054	2	0.023
morphogenesis of a polarized epithelium	GO:0001738	37	0.023
mesodermal cell migration	GO:0008078	4	0.023
organic cyclic compound catabolic process	GO:1901361	295	0.022
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	30	0.022
regulation of lymphocyte activation	GO:0051249	240	0.022
response to oxygen levels	GO:0070482	62	0.022
actin filament organization	GO:0007015	113	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.022
amine metabolic process	GO:0009308	45	0.022
membrane organization	GO:0061024	245	0.022
carbohydrate derivative catabolic process	GO:1901136	231	0.022
organonitrogen compound catabolic process	GO:1901565	264	0.022
locomotory behavior	GO:0007626	195	0.022
ventricular cardiac muscle tissue development	GO:0003229	38	0.022	Mouse
cell migration involved in endocardial cushion formation	GO:0003273	3	0.022
embryonic digit morphogenesis	GO:0042733	56	0.022
endodermal cell fate specification	GO:0001714	4	0.022
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.021
embryonic organ morphogenesis	GO:0048562	276	0.021
cyclic nucleotide metabolic process	GO:0009187	59	0.021
trabecula formation	GO:0060343	24	0.021	Mouse
endothelial cell apoptotic process	GO:0072577	9	0.021
renal vesicle induction	GO:0072034	3	0.021
non canonical wnt signaling pathway	GO:0035567	33	0.021
cytokine production	GO:0001816	319	0.021
ribose phosphate metabolic process	GO:0019693	291	0.021
regulation of establishment of protein localization	GO:0070201	181	0.021
apoptotic process involved in morphogenesis	GO:0060561	25	0.021
calcium mediated signaling	GO:0019722	46	0.021
endocardial cushion to mesenchymal transition	GO:0090500	5	0.021	Mouse
activation of transmembrane receptor protein tyrosine kinase activity	GO:0007171	3	0.021
brain morphogenesis	GO:0048854	32	0.021
regulation of cell activation	GO:0050865	289	0.021
response to transforming growth factor beta	GO:0071559	88	0.021
negative regulation of nervous system development	GO:0051961	156	0.021	Mouse
positive regulation of lymphocyte activation	GO:0051251	140	0.021
negative regulation of wnt signaling pathway	GO:0030178	73	0.020
nucleoside triphosphate catabolic process	GO:0009143	205	0.020
protein ubiquitination	GO:0016567	171	0.020
regulation of epithelial cell proliferation	GO:0050678	141	0.020
ribose phosphate biosynthetic process	GO:0046390	59	0.020
mesangial cell differentiation	GO:0072007	4	0.020
purine ribonucleotide biosynthetic process	GO:0009152	59	0.020
protein secretion	GO:0009306	111	0.020
multicellular organismal response to stress	GO:0033555	62	0.020
tendon formation	GO:0035992	4	0.020
positive regulation of cell projection organization	GO:0031346	95	0.020
ribonucleoside metabolic process	GO:0009119	245	0.020
lymphocyte differentiation	GO:0030098	242	0.020
developmental maturation	GO:0021700	193	0.020
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.020
camera type eye development	GO:0043010	266	0.020
positive regulation of transcription from rna polymerase i promoter	GO:0045943	3	0.020
purine nucleotide catabolic process	GO:0006195	211	0.020
negative regulation of immune system process	GO:0002683	209	0.020
cognition	GO:0050890	149	0.020
actin filament bundle assembly	GO:0051017	40	0.020
organelle localization	GO:0051640	179	0.020
anagen	GO:0042640	13	0.019
morphogenesis of embryonic epithelium	GO:0016331	159	0.019
potassium ion transmembrane transport	GO:0071805	43	0.019
cell type specific apoptotic process	GO:0097285	268	0.019	Mouse
establishment of organelle localization	GO:0051656	122	0.019
intestinal epithelial structure maintenance	GO:0060729	4	0.019
positive regulation of cell adhesion	GO:0045785	80	0.019
camp metabolic process	GO:0046058	40	0.019
regulation of anatomical structure size	GO:0090066	178	0.019
positive regulation of cytoplasmic transport	GO:1903651	40	0.019
negative regulation of vasculature development	GO:1901343	26	0.019
ureteric bud development	GO:0001657	94	0.019	Mouse
pigmentation	GO:0043473	71	0.019
aortic valve morphogenesis	GO:0003180	4	0.019
establishment of protein localization to membrane	GO:0090150	54	0.019
anatomical structure homeostasis	GO:0060249	145	0.019
response to organic cyclic compound	GO:0014070	198	0.019	Human
positive regulation of cell cell adhesion mediated by cadherin	GO:2000049	2	0.019
cell cell adhesion	GO:0098609	41	0.019
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.018
positive regulation of osteoclast differentiation	GO:0045672	15	0.018
positive regulation of apoptotic process	GO:0043065	217	0.018
protein localization to organelle	GO:0033365	185	0.018
cation transport	GO:0006812	399	0.018
regulation of cellular catabolic process	GO:0031329	242	0.018
fibril organization	GO:0097435	2	0.018
myotube differentiation	GO:0014902	105	0.018
heart growth	GO:0060419	45	0.018	Mouse
cellular response to lipid	GO:0071396	145	0.018	Human
regulation of muscle tissue development	GO:1901861	97	0.018	Mouse
leukocyte differentiation	GO:0002521	342	0.018
nucleoside triphosphate metabolic process	GO:0009141	230	0.018
neuromuscular process	GO:0050905	99	0.018
neuron projection guidance	GO:0097485	141	0.018
positive regulation of mechanoreceptor differentiation	GO:0045633	1	0.018
canonical wnt signaling pathway	GO:0060070	130	0.018
regulation of binding	GO:0051098	111	0.018	Mouse
cellular homeostasis	GO:0019725	240	0.017
rho protein signal transduction	GO:0007266	32	0.017
response to decreased oxygen levels	GO:0036293	59	0.017
nephron tubule morphogenesis	GO:0072078	68	0.017	Mouse
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.017
auditory receptor cell differentiation	GO:0042491	37	0.017	Mouse
divalent inorganic cation transport	GO:0072511	178	0.017
mesonephric tubule development	GO:0072164	94	0.017	Mouse
regulation of protein targeting	GO:1903533	61	0.017
feeding behavior	GO:0007631	62	0.017	Mouse
negative regulation of cell cycle	GO:0045786	123	0.017
actomyosin structure organization	GO:0031032	56	0.017
homeostasis of number of cells	GO:0048872	210	0.017
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.017
left right pattern formation	GO:0060972	23	0.017
positive regulation of cardiac muscle tissue development	GO:0055025	19	0.017	Mouse
regulation of cytokine production	GO:0001817	266	0.017
carbohydrate metabolic process	GO:0005975	230	0.017
protein localization to membrane	GO:0072657	108	0.017
regulation of intestinal epithelial structure maintenance	GO:0060730	1	0.017
energy derivation by oxidation of organic compounds	GO:0015980	77	0.017
regulation of hormone levels	GO:0010817	211	0.017
purine nucleoside metabolic process	GO:0042278	241	0.017
regulation of circadian rhythm	GO:0042752	58	0.016
midgut development	GO:0007494	4	0.016
positive regulation of neuron projection regeneration	GO:0070572	2	0.016
labyrinthine layer development	GO:0060711	49	0.016	Mouse
regulation of response to wounding	GO:1903034	189	0.016
ameboidal type cell migration	GO:0001667	128	0.016
cell maturation	GO:0048469	127	0.016
his purkinje system development	GO:0003164	4	0.016
mitotic cell cycle	GO:0000278	195	0.016
pigment cell differentiation	GO:0050931	27	0.016
wnt signaling pathway calcium modulating pathway	GO:0007223	2	0.016
protein localization to nucleus	GO:0034504	121	0.016
cation homeostasis	GO:0055080	212	0.016
striated muscle hypertrophy	GO:0014897	24	0.016	Mouse
mitochondrion distribution	GO:0048311	4	0.016
extrinsic apoptotic signaling pathway	GO:0097191	126	0.016
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.015
positive regulation of cell motility	GO:2000147	116	0.015
compartment pattern specification	GO:0007386	4	0.015
response to peptide	GO:1901652	136	0.015
pulmonary valve development	GO:0003177	5	0.015
mesonephric epithelium development	GO:0072163	94	0.015	Mouse
regulation of protein secretion	GO:0050708	82	0.015
tissue migration	GO:0090130	68	0.015
mitochondrion organization	GO:0007005	134	0.015
dorsal aorta morphogenesis	GO:0035912	5	0.015	Mouse
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.015
spinal cord motor neuron differentiation	GO:0021522	35	0.015
regulation of organelle organization	GO:0033043	289	0.015
bundle of his development	GO:0003166	4	0.015
endocardial cushion formation	GO:0003272	13	0.015
small molecule biosynthetic process	GO:0044283	132	0.015
diencephalon development	GO:0021536	63	0.015
cardiac atrium development	GO:0003230	24	0.015	Mouse
fat cell differentiation	GO:0045444	160	0.015
aorta development	GO:0035904	23	0.015	Mouse
muscle cell proliferation	GO:0033002	52	0.015	Mouse
negative regulation of cell motility	GO:2000146	61	0.015
positive regulation of intracellular transport	GO:0032388	70	0.015
limb development	GO:0060173	166	0.015
epithelial cell proliferation	GO:0050673	174	0.015
organophosphate catabolic process	GO:0046434	232	0.015
sclerotome development	GO:0061056	4	0.015
cellular response to prostaglandin stimulus	GO:0071379	2	0.014
regulation of intracellular protein transport	GO:0033157	82	0.014
regulation of carbohydrate metabolic process	GO:0006109	75	0.014
regulation of cell migration involved in sprouting angiogenesis	GO:0090049	4	0.014
spinal cord development	GO:0021510	81	0.014
negative regulation of photoreceptor cell differentiation	GO:0046533	4	0.014
positive regulation of inner ear receptor cell differentiation	GO:2000982	1	0.014
trachea cartilage morphogenesis	GO:0060535	4	0.014
leukocyte chemotaxis	GO:0030595	69	0.014
dendritic spine maintenance	GO:0097062	4	0.014
embryonic skeletal system development	GO:0048706	120	0.014
mesoderm development	GO:0007498	100	0.014
filopodium assembly	GO:0046847	19	0.014
cilium assembly	GO:0042384	81	0.014
dendrite development	GO:0016358	115	0.014
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.014
regulation of cyclic nucleotide biosynthetic process	GO:0030802	31	0.014
protein modification by small protein conjugation or removal	GO:0070647	207	0.014
negative regulation of growth	GO:0045926	99	0.014
regulation of endothelial cell apoptotic process	GO:2000351	9	0.014
inter male aggressive behavior	GO:0002121	3	0.014
ubiquitin dependent smad protein catabolic process	GO:0030579	2	0.014
cellular metal ion homeostasis	GO:0006875	151	0.014
coronary vasculature morphogenesis	GO:0060977	9	0.014	Mouse
epithelial tube branching involved in lung morphogenesis	GO:0060441	28	0.014
male gamete generation	GO:0048232	285	0.014
regulation of tube size	GO:0035150	57	0.014
regulation of neural retina development	GO:0061074	3	0.014
dephosphorylation	GO:0016311	129	0.014
regulation of apoptotic signaling pathway	GO:2001233	197	0.014
regulation of intracellular transport	GO:0032386	159	0.014
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.014
regulation of testosterone biosynthetic process	GO:2000224	2	0.014
regulation of mast cell differentiation	GO:0060375	3	0.014
extracellular matrix assembly	GO:0085029	12	0.014
glandular epithelial cell differentiation	GO:0002067	38	0.013
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.013
response to hypoxia	GO:0001666	58	0.013
central nervous system vasculogenesis	GO:0022009	3	0.013
positive regulation of synaptic plasticity	GO:0031915	4	0.013
meiotic nuclear division	GO:0007126	115	0.013
ventricular septum morphogenesis	GO:0060412	27	0.013
establishment or maintenance of cell polarity	GO:0007163	86	0.013
kidney morphogenesis	GO:0060993	83	0.013	Mouse
bone morphogenesis	GO:0060349	78	0.013
regulation of inflammatory response	GO:0050727	147	0.013
establishment of planar polarity	GO:0001736	28	0.013
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:2000764	1	0.013
biomineral tissue development	GO:0031214	64	0.013
regulation of ras protein signal transduction	GO:0046578	114	0.013
epithelial tube formation	GO:0072175	130	0.013
sensory perception of sound	GO:0007605	97	0.013
pharynx development	GO:0060465	1	0.013
glial cell fate determination	GO:0007403	3	0.013
circulatory system process	GO:0003013	197	0.013	Mouse
nephron epithelium development	GO:0072009	92	0.013
regulation of b cell activation	GO:0050864	81	0.013
visceral serous pericardium development	GO:0061032	2	0.013
cellular amine metabolic process	GO:0044106	44	0.013

Heyl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.029
disease of anatomical entity	DOID:7	0.029
disease of cellular proliferation	DOID:14566	0.021
organ system cancer	DOID:0050686	0.013
cancer	DOID:162	0.013

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