IMP: Integrative Multi-species Prediction

Mus musculus

109 known processes

Hoxb4

homeobox B4

(Aliases: Hox-2.6)

Entrez: 15412
Ensembl: ENSMUSG00000038692
UniProtKB: P10284

Process Predictions
Disease Predictions

Hoxb4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
columnar cuboidal epithelial cell maturation	GO:0002069	4	0.986	Mouse
cell cell signaling involved in mammary gland development	GO:0060764	2	0.977	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.975
embryonic skeletal system development	GO:0048706	120	0.974
intestinal epithelial cell maturation	GO:0060574	2	0.967	Mouse
nephron epithelium morphogenesis	GO:0072088	68	0.966	Mouse
trachea cartilage morphogenesis	GO:0060535	4	0.954	Mouse
stem cell differentiation	GO:0048863	268	0.941	Human Mouse
definitive hemopoiesis	GO:0060216	20	0.916
ureteric bud morphogenesis	GO:0060675	62	0.908	Mouse
skeletal system morphogenesis	GO:0048705	203	0.903
glandular epithelial cell differentiation	GO:0002067	38	0.871	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.871	Mouse
skeletal system development	GO:0001501	356	0.864
embryonic skeletal system morphogenesis	GO:0048704	91	0.850
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.842	Mouse
morphogenesis of a branching structure	GO:0001763	203	0.841	Mouse
mesonephric tubule development	GO:0072164	94	0.838	Mouse
mesonephric tubule morphogenesis	GO:0072171	63	0.830	Mouse
spinal cord development	GO:0021510	81	0.805	Mouse
lobar bronchus epithelium development	GO:0060481	5	0.803	Mouse
regionalization	GO:0003002	337	0.770
bronchiole development	GO:0060435	3	0.753	Mouse
bone marrow development	GO:0048539	3	0.751
morphogenesis of embryonic epithelium	GO:0016331	159	0.750
nephron morphogenesis	GO:0072028	69	0.745	Mouse
lung cell differentiation	GO:0060479	30	0.741	Mouse
mammary gland epithelial cell proliferation	GO:0033598	24	0.735	Mouse
cell fate commitment	GO:0045165	210	0.729
epithelial tube formation	GO:0072175	130	0.726
embryonic epithelial tube formation	GO:0001838	130	0.716
ureteric bud development	GO:0001657	94	0.715	Mouse
myeloid cell differentiation	GO:0030099	233	0.714	Mouse
renal tubule development	GO:0061326	87	0.711	Mouse
central nervous system neuron differentiation	GO:0021953	162	0.700
respiratory system development	GO:0060541	190	0.698	Mouse
leukocyte differentiation	GO:0002521	342	0.696
nephron tubule morphogenesis	GO:0072078	68	0.695	Mouse
mesenchymal epithelial cell signaling	GO:0060638	9	0.684	Mouse
negative regulation of myeloid cell differentiation	GO:0045638	38	0.683	Mouse
nephron development	GO:0072006	109	0.676	Mouse
nephron epithelium development	GO:0072009	92	0.658	Mouse
kidney morphogenesis	GO:0060993	83	0.655	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.650	Mouse
epithelial cell proliferation	GO:0050673	174	0.644	Mouse
neural tube development	GO:0021915	160	0.643
tube closure	GO:0060606	91	0.640
kidney development	GO:0001822	213	0.640	Mouse
cartilage morphogenesis	GO:0060536	11	0.635	Mouse
connective tissue development	GO:0061448	179	0.632	Mouse
mesenchyme development	GO:0060485	152	0.629	Mouse
appendage morphogenesis	GO:0035107	149	0.626
negative regulation of cell development	GO:0010721	169	0.621
neural tube formation	GO:0001841	108	0.617
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.617	Mouse
neural tube closure	GO:0001843	90	0.611
bone development	GO:0060348	120	0.605
forebrain development	GO:0030900	302	0.602
epithelial cell development	GO:0002064	159	0.594	Mouse
positive regulation of secondary heart field cardioblast proliferation	GO:0072513	4	0.590
urogenital system development	GO:0001655	261	0.586	Mouse
cartilage development	GO:0051216	140	0.578	Mouse
inner ear morphogenesis	GO:0042472	101	0.572
renal tubule morphogenesis	GO:0061333	72	0.572	Mouse
limb development	GO:0060173	166	0.570
homeostasis of number of cells	GO:0048872	210	0.568	Mouse
lung development	GO:0030324	164	0.566	Mouse
negative regulation of nervous system development	GO:0051961	156	0.565
columnar cuboidal epithelial cell development	GO:0002066	29	0.559	Mouse
dorsal spinal cord development	GO:0021516	20	0.558	Mouse
regulation of stem cell differentiation	GO:2000736	50	0.555	Human
sensory organ morphogenesis	GO:0090596	242	0.552
regulation of organ morphogenesis	GO:2000027	144	0.547	Mouse
tube formation	GO:0035148	140	0.546
nephron tubule development	GO:0072080	84	0.545	Mouse
appendage development	GO:0048736	166	0.539
renal system development	GO:0072001	225	0.537	Mouse
cell differentiation in spinal cord	GO:0021515	53	0.529
bmp signaling pathway	GO:0030509	93	0.525
endocrine system development	GO:0035270	98	0.525	Mouse
blood vessel morphogenesis	GO:0048514	285	0.522
autonomic nervous system development	GO:0048483	43	0.521
respiratory gaseous exchange	GO:0007585	43	0.502	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	159	0.494	Mouse
glial cell differentiation	GO:0010001	131	0.479
glossopharyngeal nerve morphogenesis	GO:0021615	4	0.478
lung morphogenesis	GO:0060425	50	0.474	Mouse
myeloid cell homeostasis	GO:0002262	114	0.469	Mouse
ossification	GO:0001503	216	0.460
spleen development	GO:0048536	39	0.458
negative regulation of neuron differentiation	GO:0045665	101	0.456
lung epithelial cell differentiation	GO:0060487	29	0.455	Mouse
chemotaxis	GO:0006935	247	0.440
mammary gland alveolus development	GO:0060749	22	0.439	Mouse
forebrain neuron differentiation	GO:0021879	52	0.437
neuron projection guidance	GO:0097485	141	0.436
heart morphogenesis	GO:0003007	178	0.433
embryonic limb morphogenesis	GO:0030326	126	0.426
lung secretory cell differentiation	GO:0061140	13	0.426	Mouse
positive regulation of branching involved in ureteric bud morphogenesis	GO:0090190	18	0.415	Mouse
ear morphogenesis	GO:0042471	118	0.411
respiratory system process	GO:0003016	25	0.405	Mouse
regulation of myeloid cell differentiation	GO:0045637	96	0.398	Mouse
pituitary gland development	GO:0021983	38	0.397
intestinal epithelial cell differentiation	GO:0060575	14	0.392	Mouse
telencephalon development	GO:0021537	186	0.382
camera type eye development	GO:0043010	266	0.381
regulation of neuron differentiation	GO:0045664	281	0.377
lung epithelium development	GO:0060428	37	0.374	Mouse
sensory perception	GO:0007600	245	0.373	Mouse
myeloid leukocyte differentiation	GO:0002573	119	0.373
artery development	GO:0060840	53	0.367
cell type specific apoptotic process	GO:0097285	268	0.361
digestive tract development	GO:0048565	190	0.358	Mouse
bronchus development	GO:0060433	10	0.357	Mouse
cell maturation	GO:0048469	127	0.355	Mouse
gland development	GO:0048732	330	0.355	Mouse
hindbrain development	GO:0030902	128	0.349
morphogenesis of an epithelial sheet	GO:0002011	27	0.347
positive regulation of nervous system development	GO:0051962	221	0.340
primary neural tube formation	GO:0014020	95	0.337
cranial nerve development	GO:0021545	41	0.336
ventral spinal cord interneuron differentiation	GO:0021514	16	0.326
embryonic appendage morphogenesis	GO:0035113	126	0.326
positive regulation of neuron differentiation	GO:0045666	141	0.317
developmental maturation	GO:0021700	193	0.314	Mouse
limb morphogenesis	GO:0035108	149	0.312
embryonic digit morphogenesis	GO:0042733	56	0.311
positive regulation of mesonephros development	GO:0061213	20	0.304	Mouse
morphogenesis of a polarized epithelium	GO:0001738	37	0.303
digestive system development	GO:0055123	200	0.303	Mouse
erythrocyte differentiation	GO:0030218	88	0.303
diencephalon development	GO:0021536	63	0.301
mammary gland lobule development	GO:0061377	22	0.299	Mouse
mesonephros development	GO:0001823	97	0.295	Mouse
gliogenesis	GO:0042063	141	0.295
ventral spinal cord development	GO:0021517	48	0.288
intestinal epithelial cell development	GO:0060576	12	0.282	Mouse
regulation of ossification	GO:0030278	112	0.280
subpallium neuron fate commitment	GO:0060163	2	0.278
regulation of mammary gland epithelial cell proliferation	GO:0033599	12	0.277	Mouse
positive regulation of kidney development	GO:0090184	28	0.277	Mouse
fat cell differentiation	GO:0045444	160	0.276
parasympathetic nervous system development	GO:0048486	19	0.275
lens development in camera type eye	GO:0002088	62	0.274
lung alveolus development	GO:0048286	45	0.272	Mouse
mesenchymal cell development	GO:0014031	93	0.272
sympathetic nervous system development	GO:0048485	22	0.272
digestive tract morphogenesis	GO:0048546	147	0.272
forebrain generation of neurons	GO:0021872	63	0.265
regulation of mesonephros development	GO:0061217	24	0.264	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.256
neuron fate specification	GO:0048665	30	0.255
determination of heart left right asymmetry	GO:0061371	48	0.254
negative regulation of cell proliferation	GO:0008285	296	0.252
mesoderm formation	GO:0001707	62	0.247
forebrain regionalization	GO:0021871	25	0.247
middle ear morphogenesis	GO:0042474	23	0.245
endothelial cell differentiation	GO:0045446	41	0.240	Mouse
aortic valve morphogenesis	GO:0003180	4	0.239
development of primary sexual characteristics	GO:0045137	143	0.237
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification	GO:0021913	4	0.237
ear development	GO:0043583	200	0.237
axon guidance	GO:0007411	141	0.236
central nervous system neuron development	GO:0021954	67	0.234
cerebral cortex development	GO:0021987	86	0.231
neuron death	GO:0070997	154	0.230
positive regulation of ureteric bud formation	GO:0072107	3	0.229
mammary gland epithelial cell differentiation	GO:0060644	13	0.229	Mouse
thymus development	GO:0048538	41	0.227
regulation of branching involved in ureteric bud morphogenesis	GO:0090189	22	0.226	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.225
forelimb morphogenesis	GO:0035136	40	0.223
somitogenesis	GO:0001756	69	0.221
cellular amine metabolic process	GO:0044106	44	0.219
astrocyte differentiation	GO:0048708	43	0.217
regulation of cellular ketone metabolic process	GO:0010565	66	0.216
neuron apoptotic process	GO:0051402	142	0.214
specification of organ identity	GO:0010092	30	0.214
formation of primary germ layer	GO:0001704	77	0.212
mesenchyme morphogenesis	GO:0072132	32	0.211
olfactory lobe development	GO:0021988	32	0.210
respiratory tube development	GO:0030323	167	0.209	Mouse
striated muscle tissue development	GO:0014706	293	0.208
cell fate specification	GO:0001708	72	0.206
negative regulation of immune system process	GO:0002683	209	0.205	Mouse
nerve development	GO:0021675	67	0.204
regulation of neuron apoptotic process	GO:0043523	122	0.203
positive regulation of cell development	GO:0010720	237	0.202	Fly
establishment or maintenance of cell polarity	GO:0007163	86	0.202
somite development	GO:0061053	81	0.200
epidermis development	GO:0008544	187	0.200
rhombomere 3 morphogenesis	GO:0021658	2	0.200
stem cell division	GO:0017145	30	0.199
placenta development	GO:0001890	140	0.199
regulation of kidney development	GO:0090183	40	0.197	Mouse
regulation of embryonic development	GO:0045995	71	0.195
angiogenesis	GO:0001525	201	0.194
positive regulation of stem cell differentiation	GO:2000738	23	0.194	Human
regulation of cell motility	GO:2000145	236	0.193
regulation of ureteric bud formation	GO:0072106	3	0.191
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.190
epithelial cell maturation	GO:0002070	15	0.189	Mouse
cochlea morphogenesis	GO:0090103	22	0.188
regulation of neuron death	GO:1901214	134	0.187
endocrine pancreas development	GO:0031018	29	0.187
mesenchymal cell differentiation	GO:0048762	107	0.186
embryonic forelimb morphogenesis	GO:0035115	32	0.186
cell proliferation involved in outflow tract morphogenesis	GO:0061325	4	0.185
lymphocyte differentiation	GO:0030098	242	0.185
mesonephric epithelium development	GO:0072163	94	0.185	Mouse
regulation of bmp signaling pathway	GO:0030510	60	0.184
amine metabolic process	GO:0009308	45	0.184
specification of organ position	GO:0010159	3	0.184
stem cell maintenance	GO:0019827	130	0.183
regulation of organ formation	GO:0003156	34	0.180
limbic system development	GO:0021761	72	0.179
forebrain neuron fate commitment	GO:0021877	13	0.178
skeletal muscle cell differentiation	GO:0035914	66	0.176
olfactory bulb development	GO:0021772	30	0.176
pallium development	GO:0021543	120	0.172
forebrain neuron development	GO:0021884	30	0.172
stem cell development	GO:0048864	219	0.172
adult behavior	GO:0030534	135	0.171	Mouse
cranial nerve morphogenesis	GO:0021602	26	0.171
preganglionic parasympathetic nervous system development	GO:0021783	17	0.170
development of primary male sexual characteristics	GO:0046546	88	0.169
muscle cell differentiation	GO:0042692	261	0.168
cell division	GO:0051301	120	0.168
gonad development	GO:0008406	141	0.166
rho protein signal transduction	GO:0007266	32	0.165
lung goblet cell differentiation	GO:0060480	5	0.161	Mouse
regulation of epithelial to mesenchymal transition	GO:0010717	22	0.159
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000802	1	0.159
rhombomere 5 development	GO:0021571	4	0.157
gastrulation	GO:0007369	116	0.156
astrocyte fate commitment	GO:0060018	4	0.156
peptidyl amino acid modification	GO:0018193	336	0.155
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.153
nephric duct formation	GO:0072179	4	0.153
regulation of epithelial cell proliferation	GO:0050678	141	0.152	Mouse
regulation of stem cell proliferation	GO:0072091	78	0.149
stem cell proliferation	GO:0072089	117	0.145
axonogenesis	GO:0007409	274	0.145
bone morphogenesis	GO:0060349	78	0.144
adult locomotory behavior	GO:0008344	91	0.144	Mouse
covalent chromatin modification	GO:0016569	163	0.144
cellular amino acid metabolic process	GO:0006520	103	0.143
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.143
regulation of neuron projection development	GO:0010975	169	0.142
positive regulation of apoptotic process	GO:0043065	217	0.141	Fly
neuron migration	GO:0001764	122	0.140
hindlimb morphogenesis	GO:0035137	42	0.140
hindbrain morphogenesis	GO:0021575	46	0.139
blastocyst formation	GO:0001825	33	0.138
cell fate commitment involved in pattern specification	GO:0060581	14	0.138
apoptotic signaling pathway	GO:0097190	306	0.134
extracellular matrix organization	GO:0030198	147	0.134
positive regulation of mapk cascade	GO:0043410	170	0.133
endocardial cushion morphogenesis	GO:0003203	18	0.132
embryonic eye morphogenesis	GO:0048048	29	0.132
outflow tract morphogenesis	GO:0003151	53	0.131
embryonic heart tube morphogenesis	GO:0003143	51	0.131
epithelial tube branching involved in lung morphogenesis	GO:0060441	28	0.131	Mouse
cardiac epithelial to mesenchymal transition	GO:0060317	18	0.130
nephron tubule formation	GO:0072079	20	0.129
regulation of morphogenesis of a branching structure	GO:0060688	53	0.129	Mouse
mesoderm development	GO:0007498	100	0.127
trachea development	GO:0060438	18	0.127	Mouse
regulation of cartilage development	GO:0061035	44	0.126
liver development	GO:0001889	66	0.125
regulation of chondrocyte differentiation	GO:0032330	33	0.123
negative regulation of cellular component organization	GO:0051129	194	0.123
regulation of neural retina development	GO:0061074	3	0.122
negative regulation of molecular function	GO:0044092	258	0.122
embryonic placenta development	GO:0001892	98	0.122
odontogenesis	GO:0042476	78	0.121
male gamete generation	GO:0048232	285	0.120
clara cell differentiation	GO:0060486	4	0.120
rhombomere 3 development	GO:0021569	4	0.119
mesonephric tubule formation	GO:0072172	11	0.119
retina development in camera type eye	GO:0060041	119	0.118
nitrogen compound transport	GO:0071705	271	0.118
regulation of muscle tissue development	GO:1901861	97	0.117
odontogenesis of dentin containing tooth	GO:0042475	66	0.116
t cell differentiation	GO:0030217	174	0.116
organ induction	GO:0001759	21	0.116
negative regulation of neuron death	GO:1901215	98	0.116
response to growth factor	GO:0070848	198	0.116
hepaticobiliary system development	GO:0061008	67	0.115
endochondral bone morphogenesis	GO:0060350	50	0.115
skin development	GO:0043588	220	0.115
negative regulation of protein metabolic process	GO:0051248	282	0.115
cardiac septum morphogenesis	GO:0060411	46	0.114
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.114
negative regulation of neuron projection development	GO:0010977	50	0.113
ventral spinal cord interneuron fate commitment	GO:0060579	14	0.112
cellular response to lipid	GO:0071396	145	0.112
embryonic viscerocranium morphogenesis	GO:0048703	8	0.111
kidney epithelium development	GO:0072073	121	0.111	Mouse
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.110
mesenchymal cell proliferation	GO:0010463	44	0.110
regulation of wnt signaling pathway	GO:0030111	123	0.109
endodermal cell fate specification	GO:0001714	4	0.109
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process	GO:2000763	1	0.109
embryonic heart tube formation	GO:0003144	1	0.108
regulation of cellular component size	GO:0032535	121	0.107
lens morphogenesis in camera type eye	GO:0002089	24	0.107
epithelial to mesenchymal transition	GO:0001837	47	0.106
cardiac chamber morphogenesis	GO:0003206	93	0.106
facial nerve morphogenesis	GO:0021610	11	0.106
cellular homeostasis	GO:0019725	240	0.106
regulation of cell migration	GO:0030334	219	0.106
nucleoside phosphate metabolic process	GO:0006753	338	0.104
determination of left right symmetry	GO:0007368	80	0.103
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.101
granulocyte differentiation	GO:0030851	17	0.101
spinal cord motor neuron differentiation	GO:0021522	35	0.101
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.100
cellular ketone metabolic process	GO:0042180	84	0.100
cardiac muscle tissue morphogenesis	GO:0055008	44	0.098
guanosine containing compound metabolic process	GO:1901068	144	0.097
regulation of cardioblast differentiation	GO:0051890	3	0.097
blastocyst development	GO:0001824	80	0.097
endocardial cushion formation	GO:0003272	13	0.097
tongue development	GO:0043586	18	0.097
cell differentiation involved in embryonic placenta development	GO:0060706	26	0.097
regulation of hydrolase activity	GO:0051336	246	0.096
carbohydrate derivative biosynthetic process	GO:1901137	183	0.096
facial nerve development	GO:0021561	11	0.096
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.095
establishment of planar polarity involved in neural tube closure	GO:0090177	15	0.095
lobar bronchus development	GO:0060482	6	0.094	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.092
ras protein signal transduction	GO:0007265	77	0.092
megakaryocyte differentiation	GO:0030219	26	0.091
organelle fission	GO:0048285	170	0.091
negative regulation of ossification	GO:0030279	49	0.089
positive regulation of gliogenesis	GO:0014015	27	0.089
muscle tissue development	GO:0060537	308	0.089
mitral valve morphogenesis	GO:0003183	4	0.088
segmentation	GO:0035282	93	0.088	Fly
retina morphogenesis in camera type eye	GO:0060042	45	0.088
purine ribonucleoside metabolic process	GO:0046128	241	0.087
regulation of gliogenesis	GO:0014013	50	0.086
spinal cord patterning	GO:0021511	25	0.086
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	GO:0061350	2	0.086
b cell differentiation	GO:0030183	78	0.086
ventral spinal cord interneuron specification	GO:0021521	11	0.085
somatic stem cell maintenance	GO:0035019	47	0.085
regulation of binding	GO:0051098	111	0.085
cellular response to acid chemical	GO:0071229	68	0.085
positive regulation of inner ear receptor cell differentiation	GO:2000982	1	0.084
negative regulation of bmp signaling pathway	GO:0030514	35	0.084
regulation of retina development in camera type eye	GO:1902866	3	0.084
embryonic heart tube development	GO:0035050	65	0.084
regulation of cellular response to stress	GO:0080135	159	0.083
heart formation	GO:0060914	16	0.083
rhombomere morphogenesis	GO:0021593	2	0.082
endothelium development	GO:0003158	45	0.082	Mouse
histone modification	GO:0016570	159	0.082
asymmetric stem cell division	GO:0098722	3	0.082
auditory receptor cell fate determination	GO:0042668	3	0.082
positive regulation of mesenchymal cell proliferation	GO:0002053	33	0.082
regulation of neural precursor cell proliferation	GO:2000177	70	0.082
cell fate specification involved in pattern specification	GO:0060573	11	0.082
grooming behavior	GO:0007625	16	0.082	Mouse
somatic stem cell division	GO:0048103	19	0.081
cardiac right ventricle formation	GO:0003219	3	0.081
sensory perception of pain	GO:0019233	47	0.081	Mouse
muscle contraction	GO:0006936	101	0.081
paraxial mesodermal cell fate commitment	GO:0048343	2	0.081
cation homeostasis	GO:0055080	212	0.081
cardiac chamber development	GO:0003205	108	0.080
body morphogenesis	GO:0010171	45	0.080
spinal cord association neuron differentiation	GO:0021527	14	0.080
cardiocyte differentiation	GO:0035051	87	0.080
osteoblast development	GO:0002076	17	0.080
regulation of endopeptidase activity	GO:0052548	89	0.080
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation	GO:0003257	3	0.079
mesenchymal cell proliferation involved in ureter development	GO:0072198	4	0.079
sensory perception of sound	GO:0007605	97	0.079
visceral motor neuron differentiation	GO:0021524	3	0.079
regulation of cellular amine metabolic process	GO:0033238	20	0.079
regulation of system process	GO:0044057	200	0.078
peripheral nervous system development	GO:0007422	53	0.078
trophectodermal cell differentiation	GO:0001829	21	0.078
pancreatic a cell fate commitment	GO:0003326	2	0.078
metanephros development	GO:0001656	79	0.077
endodermal cell fate commitment	GO:0001711	12	0.077
cardioblast proliferation	GO:0003263	8	0.077
developmental induction	GO:0031128	34	0.077
regulation of body fluid levels	GO:0050878	162	0.077
forebrain morphogenesis	GO:0048853	17	0.077
nucleobase containing small molecule metabolic process	GO:0055086	352	0.077
mesoderm morphogenesis	GO:0048332	64	0.076
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.076
divalent inorganic cation homeostasis	GO:0072507	138	0.076
calcium ion homeostasis	GO:0055074	127	0.076
metal ion homeostasis	GO:0055065	189	0.076
telencephalon regionalization	GO:0021978	14	0.076
carbohydrate derivative catabolic process	GO:1901136	231	0.075
regulation of fat cell differentiation	GO:0045598	81	0.075
cardiac ventricle development	GO:0003231	83	0.075
male gonad development	GO:0008584	88	0.074
mesonephric duct morphogenesis	GO:0072180	4	0.073
small gtpase mediated signal transduction	GO:0007264	97	0.073
multicellular organism growth	GO:0035264	161	0.073	Mouse
wnt signaling pathway	GO:0016055	188	0.073
paraxial mesodermal cell differentiation	GO:0048342	2	0.073
organonitrogen compound biosynthetic process	GO:1901566	192	0.073
muscle system process	GO:0003012	141	0.073
mammary gland epithelium development	GO:0061180	65	0.073	Mouse
purine containing compound metabolic process	GO:0072521	311	0.072
protein processing	GO:0016485	163	0.072
hippocampus development	GO:0021766	52	0.072
regulation of rho gtpase activity	GO:0032319	58	0.072
cardiac right atrium morphogenesis	GO:0003213	3	0.072
positive regulation of urine volume	GO:0035810	6	0.071
smad protein signal transduction	GO:0060395	21	0.071
cell substrate adhesion	GO:0031589	130	0.071
regulation of peptidase activity	GO:0052547	96	0.071
peptidyl lysine modification	GO:0018205	77	0.071
establishment of planar polarity	GO:0001736	28	0.071
regulation of osteoblast differentiation	GO:0045667	67	0.071
anion transport	GO:0006820	177	0.071
ribose phosphate metabolic process	GO:0019693	291	0.070
positive regulation of cell death	GO:0010942	224	0.070	Fly
regulation of ion transport	GO:0043269	215	0.070
organ growth	GO:0035265	117	0.070
potassium ion homeostasis	GO:0055075	4	0.070
nucleotide metabolic process	GO:0009117	332	0.070
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.070
positive regulation of cardiac muscle cell proliferation	GO:0060045	15	0.070
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.069
planar cell polarity pathway involved in pericardium morphogenesis	GO:0061354	2	0.069
apoptotic process involved in development	GO:1902742	28	0.069	Fly
regulation of cell cycle	GO:0051726	281	0.069
glycosyl compound catabolic process	GO:1901658	206	0.069
regulation of transcription involved in cell fate commitment	GO:0060850	15	0.069
regulation of cardiac muscle tissue development	GO:0055024	31	0.069
palate development	GO:0060021	76	0.068
semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:0071527	1	0.068
regulation of nucleotide catabolic process	GO:0030811	122	0.068
planar cell polarity pathway involved in outflow tract morphogenesis	GO:0061347	2	0.068
chondrocyte differentiation	GO:0002062	72	0.067
negative regulation of synapse assembly	GO:0051964	3	0.067
enteroendocrine cell differentiation	GO:0035883	16	0.066
purine nucleoside metabolic process	GO:0042278	241	0.066
cardiac ventricle morphogenesis	GO:0003208	50	0.066
male sex determination	GO:0030238	14	0.065
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.065
nucleotide catabolic process	GO:0009166	217	0.065
multi multicellular organism process	GO:0044706	109	0.064
trachea cartilage development	GO:0060534	8	0.064	Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.064
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:2000764	1	0.063
regulation of glial cell differentiation	GO:0045685	41	0.063
regulation of cell adhesion	GO:0030155	154	0.063
lung associated mesenchyme development	GO:0060484	10	0.063	Mouse
auditory receptor cell fate specification	GO:0042667	1	0.062
ribonucleotide metabolic process	GO:0009259	291	0.062
intracellular protein transport	GO:0006886	204	0.062
actin cytoskeleton organization	GO:0030036	220	0.062
atrial septum primum morphogenesis	GO:0003289	3	0.062
negative regulation of wnt signaling pathway	GO:0030178	73	0.062
mesonephric duct formation	GO:0072181	2	0.062
oligodendrocyte differentiation	GO:0048709	53	0.062
spinal cord motor neuron cell fate specification	GO:0021520	13	0.062
regulation of protein localization	GO:0032880	231	0.062
sensory perception of mechanical stimulus	GO:0050954	107	0.062
positive regulation of map kinase activity	GO:0043406	84	0.062
cardiac septum development	GO:0003279	59	0.061
regulation of erythrocyte differentiation	GO:0045646	23	0.061
positive regulation of protein modification process	GO:0031401	299	0.061
glycosyl compound metabolic process	GO:1901657	246	0.061
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.061
regulation of organelle organization	GO:0033043	289	0.061
regulation of bone mineralization	GO:0030500	31	0.060
mammary gland duct morphogenesis	GO:0060603	38	0.060
regulation of vasculature development	GO:1901342	88	0.060
apoptotic process involved in morphogenesis	GO:0060561	25	0.060	Fly
regulation of cell projection organization	GO:0031344	206	0.060
cell adhesion	GO:0007155	329	0.060
gtp catabolic process	GO:0006184	143	0.059
regulation of mesenchymal cell proliferation involved in ureter development	GO:0072199	3	0.059
muscle tissue morphogenesis	GO:0060415	53	0.059
protein modification by small protein conjugation or removal	GO:0070647	207	0.059
neural tube patterning	GO:0021532	43	0.059
regulation of striated muscle cell differentiation	GO:0051153	81	0.059
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.059
regulation of actin cytoskeleton organization	GO:0032956	84	0.059

Hoxb4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.097
cancer	DOID:162	0.078
organ system cancer	DOID:0050686	0.078

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