IMP: Integrative Multi-species Prediction

Mus musculus

19 known processes

Hps5

Hermansky-Pudlak syndrome 5 homolog (human)

(Aliases: hz,C85120,MGC99886,maroon,AI646796,haze,mr,ru2,AL022647,ru-2)

Ensembl: ENSMUSG00000014418
Entrez: 246694
UniProtKB: Q640Q9
UniProtKB: P59438
UniProtKB: E9Q3X4

Process Predictions
Disease Predictions

Hps5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
pigment accumulation	GO:0043476	1	1.000
establishment of melanosome localization	GO:0032401	11	0.993
pigment granule localization	GO:0051875	13	0.967
melanosome transport	GO:0032402	11	0.925
melanosome localization	GO:0032400	12	0.922
coagulation	GO:0050817	78	0.902
melanosome organization	GO:0032438	8	0.853
anterograde synaptic vesicle transport	GO:0048490	15	0.844
anterograde axon cargo transport	GO:0008089	20	0.826
microtubule based transport	GO:0010970	50	0.825
blood coagulation	GO:0007596	76	0.790
microtubule based movement	GO:0007018	84	0.773
hemostasis	GO:0007599	78	0.766
pigment granule transport	GO:0051904	12	0.731
regulation of natural killer cell activation	GO:0032814	22	0.712
vesicle localization	GO:0051648	86	0.687
cytoskeleton dependent intracellular transport	GO:0030705	50	0.679
pigment cell differentiation	GO:0050931	27	0.629
pigmentation	GO:0043473	71	0.627
cellular pigmentation	GO:0033059	20	0.583
secretion of lysosomal enzymes	GO:0033299	6	0.555
melanocyte differentiation	GO:0030318	25	0.550
regulation of body fluid levels	GO:0050878	162	0.525
developmental pigmentation	GO:0048066	40	0.492	Zebrafish
synaptic vesicle localization	GO:0097479	59	0.436
secretory granule organization	GO:0033363	20	0.400
establishment of vesicle localization	GO:0051650	81	0.383
establishment of organelle localization	GO:0051656	122	0.353
axon cargo transport	GO:0008088	33	0.345
natural killer cell degranulation	GO:0043320	3	0.329
pigment granule organization	GO:0048753	9	0.316
natural killer cell activation	GO:0030101	44	0.312
organelle localization	GO:0051640	179	0.304
synaptic transmission	GO:0007268	329	0.303
lytic vacuole organization	GO:0080171	21	0.284
positive regulation of natural killer cell activation	GO:0032816	15	0.283
vesicle organization	GO:0016050	60	0.273
positive regulation of lymphocyte activation	GO:0051251	140	0.272
wound healing	GO:0042060	157	0.268
natural killer cell activation involved in immune response	GO:0002323	10	0.245
establishment of synaptic vesicle localization	GO:0097480	57	0.220
regulation of pigment cell differentiation	GO:0050932	7	0.181
establishment of pigment granule localization	GO:0051905	12	0.175
microtubule based process	GO:0007017	236	0.174
regulation of lymphocyte activation	GO:0051249	240	0.165
synaptic vesicle transport	GO:0048489	57	0.153
endomembrane system organization	GO:0010256	147	0.148
neuroepithelial cell differentiation	GO:0060563	37	0.146
positive regulation of cell activation	GO:0050867	158	0.144
organophosphate catabolic process	GO:0046434	232	0.142
regulation of cell activation	GO:0050865	289	0.121
cellular nitrogen compound catabolic process	GO:0044270	280	0.120
nucleoside phosphate catabolic process	GO:1901292	222	0.092
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.090
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.088
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.084
lysosome organization	GO:0007040	21	0.083
nucleoside phosphate metabolic process	GO:0006753	338	0.082
nucleotide metabolic process	GO:0009117	332	0.081
purine nucleoside metabolic process	GO:0042278	241	0.076
purine nucleotide metabolic process	GO:0006163	302	0.073
antigen processing and presentation of lipid antigen via mhc class ib	GO:0048003	3	0.072
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.071
nucleoside catabolic process	GO:0009164	206	0.070
purine containing compound metabolic process	GO:0072521	311	0.068
leukocyte differentiation	GO:0002521	342	0.067
transmembrane transport	GO:0055085	412	0.067
exosomal secretion	GO:1990182	1	0.066
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.065
nucleoside triphosphate metabolic process	GO:0009141	230	0.062
nucleobase containing small molecule metabolic process	GO:0055086	352	0.061
ribose phosphate metabolic process	GO:0019693	291	0.061
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.059
ribonucleoside metabolic process	GO:0009119	245	0.059
cytoplasmic transport	GO:0016482	234	0.057
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.057
organonitrogen compound catabolic process	GO:1901565	264	0.055
organic cyclic compound catabolic process	GO:1901361	295	0.054
ribonucleoside catabolic process	GO:0042454	206	0.054
nucleoside metabolic process	GO:0009116	246	0.054
cellular lipid metabolic process	GO:0044255	323	0.054
eye pigmentation	GO:0048069	3	0.053	Zebrafish
ribonucleotide metabolic process	GO:0009259	291	0.053
regulation of cellular catabolic process	GO:0031329	242	0.052
purine ribonucleotide metabolic process	GO:0009150	290	0.051
regulation of lymphocyte differentiation	GO:0045619	107	0.051
purine nucleotide catabolic process	GO:0006195	211	0.051
camera type eye development	GO:0043010	266	0.049
glycosyl compound metabolic process	GO:1901657	246	0.049
aromatic compound catabolic process	GO:0019439	286	0.048
purine nucleoside catabolic process	GO:0006152	205	0.045
cytotoxic t cell degranulation	GO:0043316	2	0.044
heterocycle catabolic process	GO:0046700	280	0.044
protein targeting	GO:0006605	143	0.044
cellular protein catabolic process	GO:0044257	155	0.043
purine ribonucleoside catabolic process	GO:0046130	205	0.043
gtp metabolic process	GO:0046039	144	0.043
neuromuscular process	GO:0050905	99	0.043
nucleoside triphosphate catabolic process	GO:0009143	205	0.043
glycosyl compound catabolic process	GO:1901658	206	0.042
cation transmembrane transport	GO:0098655	266	0.042
lymphocyte mediated immunity	GO:0002449	139	0.041
protein targeting to vacuole	GO:0006623	3	0.041
nitrogen compound transport	GO:0071705	271	0.040
vacuole organization	GO:0007033	38	0.039
nucleotide catabolic process	GO:0009166	217	0.039
reactive oxygen species biosynthetic process	GO:1903409	8	0.038
ribonucleotide catabolic process	GO:0009261	208	0.038
immune effector process	GO:0002252	321	0.038
purine ribonucleotide catabolic process	GO:0009154	208	0.038
purine ribonucleoside metabolic process	GO:0046128	241	0.038
t cell differentiation	GO:0030217	174	0.038
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.038
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.038
carbohydrate derivative catabolic process	GO:1901136	231	0.037
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.036
macromolecule catabolic process	GO:0009057	281	0.035
inorganic ion transmembrane transport	GO:0098660	234	0.035
membrane organization	GO:0061024	245	0.035
reactive oxygen species metabolic process	GO:0072593	84	0.034
lipid homeostasis	GO:0055088	63	0.034
establishment of protein localization to vacuole	GO:0072666	4	0.033
lipid localization	GO:0010876	126	0.033
regulation of endocytosis	GO:0030100	69	0.032
protein localization to vacuole	GO:0072665	4	0.032
intracellular protein transport	GO:0006886	204	0.031
defense response to bacterium	GO:0042742	119	0.031
natural killer cell mediated cytotoxicity	GO:0042267	29	0.030
protein secretion	GO:0009306	111	0.030
t cell activation	GO:0042110	289	0.029
positive regulation of cellular catabolic process	GO:0031331	148	0.028
positive regulation of pigment cell differentiation	GO:0050942	5	0.028
regulation of protein catabolic process	GO:0042176	108	0.028
protein catabolic process	GO:0030163	221	0.028
purine containing compound catabolic process	GO:0072523	213	0.028
establishment of protein localization to organelle	GO:0072594	118	0.028
positive regulation of phagocytosis	GO:0050766	26	0.027
neuromuscular process controlling balance	GO:0050885	59	0.027
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.027
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.026
cellular homeostasis	GO:0019725	240	0.026
cellular macromolecule catabolic process	GO:0044265	206	0.026
regulation of cellular ketone metabolic process	GO:0010565	66	0.026
inorganic cation transmembrane transport	GO:0098662	207	0.025
positive regulation of cellular protein catabolic process	GO:1903364	34	0.025
regulation of purine nucleotide metabolic process	GO:1900542	169	0.025
cell adhesion	GO:0007155	329	0.025
adaptive immune response	GO:0002250	155	0.025
cation transport	GO:0006812	399	0.024
positive regulation of leukocyte differentiation	GO:1902107	86	0.024
amine metabolic process	GO:0009308	45	0.024
early endosome to late endosome transport	GO:0045022	2	0.024
regulation of nucleotide metabolic process	GO:0006140	169	0.024
cellular amine metabolic process	GO:0044106	44	0.024
apoptotic signaling pathway	GO:0097190	306	0.023
cellular amino acid metabolic process	GO:0006520	103	0.023
regulation of ion transport	GO:0043269	215	0.023
positive regulation of cellular amine metabolic process	GO:0033240	5	0.023
carbohydrate derivative biosynthetic process	GO:1901137	183	0.022
regulation of cellular amino acid metabolic process	GO:0006521	5	0.022
regulation of leukocyte differentiation	GO:1902105	159	0.022
phospholipid metabolic process	GO:0006644	87	0.022
gtp catabolic process	GO:0006184	143	0.021
embryonic organ morphogenesis	GO:0048562	276	0.021
protein targeting to lysosome	GO:0006622	2	0.021
ear morphogenesis	GO:0042471	118	0.021
carbohydrate metabolic process	GO:0005975	230	0.021
endosome organization	GO:0007032	9	0.021
ear development	GO:0043583	200	0.021
regulation of cellular protein catabolic process	GO:1903362	61	0.021
leukocyte mediated cytotoxicity	GO:0001909	62	0.020
regulation of hydrolase activity	GO:0051336	246	0.020
ion transmembrane transport	GO:0034220	361	0.020
monocarboxylic acid metabolic process	GO:0032787	191	0.020
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.019
antigen processing and presentation	GO:0019882	47	0.019
positive regulation of protein catabolic process	GO:0045732	60	0.019
natural killer cell mediated immunity	GO:0002228	29	0.019
sensory organ morphogenesis	GO:0090596	242	0.019
guanosine containing compound catabolic process	GO:1901069	144	0.019
organic hydroxy compound metabolic process	GO:1901615	203	0.019
lymphocyte differentiation	GO:0030098	242	0.018
cation homeostasis	GO:0055080	212	0.018
neurotransmitter transport	GO:0006836	76	0.018
retina development in camera type eye	GO:0060041	119	0.018
phagocytosis	GO:0006909	66	0.018
cell activation involved in immune response	GO:0002263	126	0.018
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.018
endocytosis	GO:0006897	168	0.018
membrane fusion	GO:0061025	38	0.018
organonitrogen compound biosynthetic process	GO:1901566	192	0.017
protein maturation	GO:0051604	176	0.017
cellular ketone metabolic process	GO:0042180	84	0.017
regulation of alpha beta t cell activation	GO:0046634	53	0.017
cellular ion homeostasis	GO:0006873	165	0.017
platelet activation	GO:0030168	40	0.017
g protein coupled receptor signaling pathway	GO:0007186	243	0.017
maintenance of location	GO:0051235	89	0.016
glucose homeostasis	GO:0042593	128	0.016
interleukin 8 production	GO:0032637	4	0.016
lipid biosynthetic process	GO:0008610	179	0.016
regulation of cellular amine metabolic process	GO:0033238	20	0.016
innate immune response	GO:0045087	157	0.016
regulation of t cell activation	GO:0050863	170	0.016
protein localization to organelle	GO:0033365	185	0.016
leukocyte mediated immunity	GO:0002443	174	0.016
guanosine containing compound metabolic process	GO:1901068	144	0.015
cell killing	GO:0001906	67	0.015
chromatin modification	GO:0016568	187	0.015
small gtpase mediated signal transduction	GO:0007264	97	0.015
urogenital system development	GO:0001655	261	0.015
myeloid cell differentiation	GO:0030099	233	0.015
compound eye development	GO:0048749	1	0.015
peptidyl amino acid modification	GO:0018193	336	0.014
regulation of phagocytosis	GO:0050764	33	0.014
alpha beta t cell differentiation	GO:0046632	69	0.014
lymphocyte activation involved in immune response	GO:0002285	93	0.014
regulation of nucleotide catabolic process	GO:0030811	122	0.014
oxidation reduction process	GO:0055114	342	0.014
positive regulation of hydrolase activity	GO:0051345	148	0.014
platelet aggregation	GO:0070527	20	0.014
divalent metal ion transport	GO:0070838	172	0.014
protein processing	GO:0016485	163	0.014
regulation of t cell differentiation	GO:0045580	83	0.014
actin cytoskeleton organization	GO:0030036	220	0.014
muscle tissue development	GO:0060537	308	0.014
regulation of interleukin 8 production	GO:0032677	3	0.013
cellular chemical homeostasis	GO:0055082	215	0.013
cellular carbohydrate metabolic process	GO:0044262	119	0.013
pigment metabolic process	GO:0042440	32	0.013
positive regulation of endocytosis	GO:0045807	42	0.013
regulation of organelle organization	GO:0033043	289	0.013
glycoprotein metabolic process	GO:0009100	116	0.013
cytokine production	GO:0001816	319	0.012
adult behavior	GO:0030534	135	0.012
anion transport	GO:0006820	177	0.012
positive regulation of nucleoside metabolic process	GO:0045979	91	0.012
organelle assembly	GO:0070925	177	0.012
cell type specific apoptotic process	GO:0097285	268	0.012
negative regulation of cellular component organization	GO:0051129	194	0.012
hematopoietic progenitor cell differentiation	GO:0002244	143	0.012
alpha amino acid metabolic process	GO:1901605	59	0.012
development of primary sexual characteristics	GO:0045137	143	0.012
male gamete generation	GO:0048232	285	0.012
regulation of nucleoside metabolic process	GO:0009118	130	0.012
neuronal action potential	GO:0019228	54	0.012
glycoprotein biosynthetic process	GO:0009101	89	0.012
neurotransmitter secretion	GO:0007269	62	0.012
organophosphate biosynthetic process	GO:0090407	122	0.012
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.012
single organismal cell cell adhesion	GO:0016337	131	0.012
protein modification by small protein conjugation	GO:0032446	187	0.011
regulation of proteolysis	GO:0030162	164	0.011
negative regulation of intracellular signal transduction	GO:1902532	167	0.011
positive regulation of lymphocyte differentiation	GO:0045621	61	0.011
cellular protein complex assembly	GO:0043623	116	0.011
protein ubiquitination	GO:0016567	171	0.011
protein modification by small protein conjugation or removal	GO:0070647	207	0.011
rna interference	GO:0016246	2	0.011
t cell mediated immunity	GO:0002456	50	0.011
response to extracellular stimulus	GO:0009991	127	0.011
dephosphorylation	GO:0016311	129	0.011
organic anion transport	GO:0015711	137	0.011
renal system development	GO:0072001	225	0.011
leukocyte activation involved in immune response	GO:0002366	126	0.011
asymmetric stem cell division	GO:0098722	3	0.011
positive regulation of t cell differentiation	GO:0045582	52	0.011
wnt signaling pathway	GO:0016055	188	0.011
regulation of secretion by cell	GO:1903530	249	0.011
posttranscriptional regulation of gene expression	GO:0010608	155	0.011
homotypic cell cell adhesion	GO:0034109	28	0.011
positive regulation of secretion	GO:0051047	130	0.011
carboxylic acid biosynthetic process	GO:0046394	86	0.011
negative regulation of protein metabolic process	GO:0051248	282	0.011
tissue remodeling	GO:0048771	102	0.011
calcium ion dependent exocytosis	GO:0017156	35	0.011
hormone secretion	GO:0046879	128	0.011
organic acid biosynthetic process	GO:0016053	86	0.011
small molecule biosynthetic process	GO:0044283	132	0.010
negative regulation of cell development	GO:0010721	169	0.010
gonad development	GO:0008406	141	0.010
positive regulation of programmed cell death	GO:0043068	218	0.010
sulfur compound biosynthetic process	GO:0044272	37	0.010
positive regulation of interferon alpha production	GO:0032727	4	0.010
positive regulation of protein modification process	GO:0031401	299	0.010
ossification	GO:0001503	216	0.010
myeloid leukocyte mediated immunity	GO:0002444	42	0.010
glycerolipid metabolic process	GO:0046486	122	0.010
regulation of exocytosis	GO:0017157	61	0.010
positive regulation of developmental pigmentation	GO:0048087	6	0.010
regulation of gtp catabolic process	GO:0033124	113	0.010
negative regulation of cellular protein metabolic process	GO:0032269	247	0.010
positive regulation of secretion by cell	GO:1903532	114	0.010

Hps5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.032
disease of anatomical entity	DOID:7	0.032
immune system disease	DOID:2914	0.025
musculoskeletal system disease	DOID:17	0.014
inherited metabolic disorder	DOID:655	0.014
disease of metabolism	DOID:0014667	0.014
connective tissue disease	DOID:65	0.013
cancer	DOID:162	0.013
disease of cellular proliferation	DOID:14566	0.013
bone disease	DOID:0080001	0.011

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