IMP: Integrative Multi-species Prediction

Mus musculus

33 known processes

Hps6

Hermansky-Pudlak syndrome 6

(Aliases: 5330434M19Rik,ru,MGC31055,BLOC2)

Entrez: 20170
Ensembl: ENSMUSG00000074811
UniProtKB: Q8BLY7

Process Predictions
Disease Predictions

Hps6 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
pigment accumulation	GO:0043476	1	0.989
pigmentation	GO:0043473	71	0.942
establishment of melanosome localization	GO:0032401	11	0.926
melanosome organization	GO:0032438	8	0.845
coagulation	GO:0050817	78	0.833
pigment granule localization	GO:0051875	13	0.832
melanocyte differentiation	GO:0030318	25	0.807
hemostasis	GO:0007599	78	0.783
anterograde axon cargo transport	GO:0008089	20	0.782
microtubule based transport	GO:0010970	50	0.774
microtubule based movement	GO:0007018	84	0.749
pigment cell differentiation	GO:0050931	27	0.721
regulation of natural killer cell activation	GO:0032814	22	0.699
melanosome transport	GO:0032402	11	0.628
regulation of body fluid levels	GO:0050878	162	0.538
melanosome localization	GO:0032400	12	0.534
secretion of lysosomal enzymes	GO:0033299	6	0.503
wound healing	GO:0042060	157	0.455
secretory granule organization	GO:0033363	20	0.403
anterograde synaptic vesicle transport	GO:0048490	15	0.383
vesicle organization	GO:0016050	60	0.355
vesicle localization	GO:0051648	86	0.355
cellular pigmentation	GO:0033059	20	0.335
pigment granule transport	GO:0051904	12	0.319
blood coagulation	GO:0007596	76	0.301
neuroepithelial cell differentiation	GO:0060563	37	0.300
pigment granule organization	GO:0048753	9	0.296
synaptic vesicle transport	GO:0048489	57	0.240
cytoskeleton dependent intracellular transport	GO:0030705	50	0.228
developmental pigmentation	GO:0048066	40	0.224
establishment of organelle localization	GO:0051656	122	0.218
natural killer cell activation	GO:0030101	44	0.201
pigment biosynthetic process	GO:0046148	26	0.153
axon cargo transport	GO:0008088	33	0.142
positive regulation of natural killer cell activation	GO:0032816	15	0.123
regulation of lymphocyte activation	GO:0051249	240	0.121
regulation of pigment cell differentiation	GO:0050932	7	0.113
regulation of cell activation	GO:0050865	289	0.108
establishment of vesicle localization	GO:0051650	81	0.103
lytic vacuole organization	GO:0080171	21	0.102
positive regulation of cell activation	GO:0050867	158	0.094
establishment of synaptic vesicle localization	GO:0097480	57	0.091
organelle localization	GO:0051640	179	0.088
lysosome organization	GO:0007040	21	0.084
eye pigmentation	GO:0048069	3	0.078
synaptic vesicle localization	GO:0097479	59	0.078
microtubule based process	GO:0007017	236	0.072
natural killer cell degranulation	GO:0043320	3	0.069
positive regulation of lymphocyte activation	GO:0051251	140	0.066
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.054
synaptic transmission	GO:0007268	329	0.051
nucleoside metabolic process	GO:0009116	246	0.050
cellular amino acid metabolic process	GO:0006520	103	0.048
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.048
protein targeting	GO:0006605	143	0.047
establishment of pigment granule localization	GO:0051905	12	0.047
natural killer cell activation involved in immune response	GO:0002323	10	0.046
camera type eye development	GO:0043010	266	0.044
aromatic compound catabolic process	GO:0019439	286	0.042
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.042
protein targeting to vacuole	GO:0006623	3	0.041
retina development in camera type eye	GO:0060041	119	0.040
vacuole organization	GO:0007033	38	0.039
nucleotide metabolic process	GO:0009117	332	0.038
protein secretion	GO:0009306	111	0.036
pigment metabolic process	GO:0042440	32	0.035
ketone body metabolic process	GO:1902224	3	0.035
leukocyte differentiation	GO:0002521	342	0.035
cytoplasmic transport	GO:0016482	234	0.034
purine ribonucleoside metabolic process	GO:0046128	241	0.034
alpha amino acid metabolic process	GO:1901605	59	0.034
heterocycle catabolic process	GO:0046700	280	0.033
carbohydrate derivative catabolic process	GO:1901136	231	0.033
nucleotide catabolic process	GO:0009166	217	0.032
regulation of cellular amino acid metabolic process	GO:0006521	5	0.032
reactive oxygen species biosynthetic process	GO:1903409	8	0.031
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.030
regulation of leukocyte differentiation	GO:1902105	159	0.030
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.029
adaptive immune response	GO:0002250	155	0.029
neuromuscular process controlling balance	GO:0050885	59	0.029
negative regulation of protein metabolic process	GO:0051248	282	0.029
small gtpase mediated signal transduction	GO:0007264	97	0.029
cell adhesion	GO:0007155	329	0.029
organic cyclic compound catabolic process	GO:1901361	295	0.027
regulation of organelle organization	GO:0033043	289	0.027
t cell activation	GO:0042110	289	0.027
purine containing compound metabolic process	GO:0072521	311	0.027
glycosyl compound metabolic process	GO:1901657	246	0.026
nucleoside catabolic process	GO:0009164	206	0.026
purine ribonucleoside catabolic process	GO:0046130	205	0.026
organic hydroxy compound transport	GO:0015850	93	0.025
amine metabolic process	GO:0009308	45	0.025
immune effector process	GO:0002252	321	0.025
cation transport	GO:0006812	399	0.025
cellular amine metabolic process	GO:0044106	44	0.024
organonitrogen compound catabolic process	GO:1901565	264	0.024
nucleobase containing small molecule metabolic process	GO:0055086	352	0.024
lymphocyte mediated immunity	GO:0002449	139	0.024
purine nucleotide catabolic process	GO:0006195	211	0.023
lipid localization	GO:0010876	126	0.023
purine containing compound catabolic process	GO:0072523	213	0.023
protein localization to vacuole	GO:0072665	4	0.023
cellular nitrogen compound catabolic process	GO:0044270	280	0.023
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.023
purine nucleoside catabolic process	GO:0006152	205	0.022
t cell differentiation	GO:0030217	174	0.022
antigen processing and presentation exogenous lipid antigen via mhc class ib	GO:0048007	3	0.022
response to lipopolysaccharide	GO:0032496	128	0.022
regulation of secretion by cell	GO:1903530	249	0.022
nucleoside phosphate catabolic process	GO:1901292	222	0.022
negative regulation of phosphate metabolic process	GO:0045936	184	0.022
glycosyl compound catabolic process	GO:1901658	206	0.022
establishment of protein localization to organelle	GO:0072594	118	0.022
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.022
stem cell proliferation	GO:0072089	117	0.021
purine ribonucleotide catabolic process	GO:0009154	208	0.021
lymphocyte differentiation	GO:0030098	242	0.021
apoptotic signaling pathway	GO:0097190	306	0.021
regulation of cellular ketone metabolic process	GO:0010565	66	0.021
guanosine containing compound catabolic process	GO:1901069	144	0.021
transmembrane transport	GO:0055085	412	0.021
antigen processing and presentation of lipid antigen via mhc class ib	GO:0048003	3	0.021
nucleoside triphosphate catabolic process	GO:0009143	205	0.021
purine ribonucleotide metabolic process	GO:0009150	290	0.021
positive regulation of cell development	GO:0010720	237	0.021
cation transmembrane transport	GO:0098655	266	0.021
placenta development	GO:0001890	140	0.020
nucleoside phosphate metabolic process	GO:0006753	338	0.020
ribonucleotide metabolic process	GO:0009259	291	0.020
cell killing	GO:0001906	67	0.020
glycoprotein metabolic process	GO:0009100	116	0.020
cell activation involved in immune response	GO:0002263	126	0.020
intracellular protein transport	GO:0006886	204	0.020
cellular lipid metabolic process	GO:0044255	323	0.019
compound eye development	GO:0048749	1	0.019
fatty acid metabolic process	GO:0006631	121	0.019
positive regulation of pigment cell differentiation	GO:0050942	5	0.019
regulation of hydrolase activity	GO:0051336	246	0.019
cellular ketone metabolic process	GO:0042180	84	0.018
inorganic cation transmembrane transport	GO:0098662	207	0.018
establishment of protein localization to vacuole	GO:0072666	4	0.018
endomembrane system organization	GO:0010256	147	0.018
regulation of lymphocyte differentiation	GO:0045619	107	0.018
regulation of protein transport	GO:0051223	163	0.018
dna metabolic process	GO:0006259	303	0.018
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.018
defense response to bacterium	GO:0042742	119	0.018
guanosine containing compound metabolic process	GO:1901068	144	0.018
negative regulation of cellular protein metabolic process	GO:0032269	247	0.018
purine nucleoside metabolic process	GO:0042278	241	0.017
regulation of ion transport	GO:0043269	215	0.017
monocarboxylic acid metabolic process	GO:0032787	191	0.017
regulation of cellular amine metabolic process	GO:0033238	20	0.017
ribonucleotide catabolic process	GO:0009261	208	0.017
actin cytoskeleton organization	GO:0030036	220	0.017
regulation of cellular catabolic process	GO:0031329	242	0.017
negative regulation of phosphorus metabolic process	GO:0010563	184	0.017
organic hydroxy compound metabolic process	GO:1901615	203	0.017
cellular homeostasis	GO:0019725	240	0.017
cellular macromolecule catabolic process	GO:0044265	206	0.017
regulation of endocytosis	GO:0030100	69	0.017
nitrogen compound transport	GO:0071705	271	0.017
positive regulation of cellular amine metabolic process	GO:0033240	5	0.016
cytokine production	GO:0001816	319	0.016
regulation of secretion	GO:0051046	274	0.016
neuromuscular process	GO:0050905	99	0.016
lipid homeostasis	GO:0055088	63	0.016
purine nucleotide metabolic process	GO:0006163	302	0.016
inorganic ion transmembrane transport	GO:0098660	234	0.016
positive regulation of nervous system development	GO:0051962	221	0.016
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.016
sensory organ morphogenesis	GO:0090596	242	0.016
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.016
organonitrogen compound biosynthetic process	GO:1901566	192	0.016
gtp catabolic process	GO:0006184	143	0.016
ribonucleoside catabolic process	GO:0042454	206	0.016
cell type specific apoptotic process	GO:0097285	268	0.016
negative regulation of cellular amine metabolic process	GO:0033239	1	0.016
g protein coupled receptor signaling pathway	GO:0007186	243	0.016
antigen processing and presentation	GO:0019882	47	0.015
myeloid cell differentiation	GO:0030099	233	0.015
oxidation reduction process	GO:0055114	342	0.015
carbohydrate derivative biosynthetic process	GO:1901137	183	0.015
reactive oxygen species metabolic process	GO:0072593	84	0.015
cation homeostasis	GO:0055080	212	0.015
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.015
alpha beta t cell differentiation	GO:0046632	69	0.015
regulation of defense response	GO:0031347	233	0.014
protein maturation	GO:0051604	176	0.014
response to molecule of bacterial origin	GO:0002237	143	0.014
positive regulation of protein modification process	GO:0031401	299	0.014
regulation of nucleotide metabolic process	GO:0006140	169	0.014
protein processing	GO:0016485	163	0.014
ribonucleoside metabolic process	GO:0009119	245	0.014
membrane organization	GO:0061024	245	0.014
positive regulation of nucleoside metabolic process	GO:0045979	91	0.013
cellular ion homeostasis	GO:0006873	165	0.013
defense response to other organism	GO:0098542	197	0.013
regulation of inflammatory response	GO:0050727	147	0.013
neuronal action potential	GO:0019228	54	0.013
regulation of t cell activation	GO:0050863	170	0.013
organophosphate catabolic process	GO:0046434	232	0.013
ossification	GO:0001503	216	0.013
regulation of t cell differentiation	GO:0045580	83	0.013
protein catabolic process	GO:0030163	221	0.013
embryonic organ morphogenesis	GO:0048562	276	0.013
cell division	GO:0051301	120	0.013
negative regulation of intracellular signal transduction	GO:1902532	167	0.013
chromatin modification	GO:0016568	187	0.013
ras protein signal transduction	GO:0007265	77	0.013
positive regulation of secretion by cell	GO:1903532	114	0.013
maintenance of location	GO:0051235	89	0.013
regulation of protein localization	GO:0032880	231	0.013
canonical wnt signaling pathway involved in negative regulation of apoptotic process	GO:0044336	4	0.013
spermatogenesis	GO:0007283	284	0.013
positive regulation of lymphocyte differentiation	GO:0045621	61	0.013
regulation of neurotransmitter transport	GO:0051588	35	0.012
thymus development	GO:0048538	41	0.012
cellular protein catabolic process	GO:0044257	155	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.012
negative regulation of cellular component organization	GO:0051129	194	0.012
alpha beta t cell activation	GO:0046631	91	0.012
response to inorganic substance	GO:0010035	96	0.012
ear development	GO:0043583	200	0.012
negative regulation of phosphorylation	GO:0042326	166	0.012
leukocyte activation involved in immune response	GO:0002366	126	0.012
regulation of transferase activity	GO:0051338	263	0.012
positive regulation of secretion	GO:0051047	130	0.012
regulation of anatomical structure size	GO:0090066	178	0.012
negative regulation of molecular function	GO:0044092	258	0.012
carbohydrate metabolic process	GO:0005975	230	0.012
regulation of interleukin 8 production	GO:0032677	3	0.012
gtp metabolic process	GO:0046039	144	0.012
positive regulation of cellular catabolic process	GO:0031331	148	0.012
single organismal cell cell adhesion	GO:0016337	131	0.012
small molecule biosynthetic process	GO:0044283	132	0.012
interleukin 8 production	GO:0032637	4	0.012
adult behavior	GO:0030534	135	0.012
tyrosine metabolic process	GO:0006570	4	0.012
innate immune response	GO:0045087	157	0.012
mapk cascade	GO:0000165	281	0.012
regulation of response to wounding	GO:1903034	189	0.012
glycoprotein biosynthetic process	GO:0009101	89	0.011
ribose phosphate metabolic process	GO:0019693	291	0.011
forebrain development	GO:0030900	302	0.011
cellular response to lipopolysaccharide	GO:0071222	77	0.011
early endosome to late endosome transport	GO:0045022	2	0.011
extrinsic apoptotic signaling pathway	GO:0097191	126	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.011
male gamete generation	GO:0048232	285	0.011
nucleoside triphosphate metabolic process	GO:0009141	230	0.011
tissue remodeling	GO:0048771	102	0.011
negative regulation of cell activation	GO:0050866	111	0.011
organophosphate biosynthetic process	GO:0090407	122	0.011
muscle system process	GO:0003012	141	0.011
regulation of proteolysis	GO:0030162	164	0.011
regulation of kinase activity	GO:0043549	249	0.011
regulation of apoptotic signaling pathway	GO:2001233	197	0.011
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.011
natural killer cell mediated cytotoxicity	GO:0042267	29	0.011
protein localization to organelle	GO:0033365	185	0.011
regulation of establishment of protein localization	GO:0070201	181	0.011
negative regulation of cell cycle	GO:0045786	123	0.011
cytotoxic t cell degranulation	GO:0043316	2	0.011
positive regulation of nucleotide catabolic process	GO:0030813	88	0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.011
multicellular organismal signaling	GO:0035637	91	0.011
cellular response to organonitrogen compound	GO:0071417	145	0.011
negative regulation of cell development	GO:0010721	169	0.010
positive regulation of hydrolase activity	GO:0051345	148	0.010
rna interference	GO:0016246	2	0.010
response to organonitrogen compound	GO:0010243	246	0.010
germ cell development	GO:0007281	185	0.010
cellular response to lipid	GO:0071396	145	0.010
lymphocyte activation involved in immune response	GO:0002285	93	0.010
positive regulation of nucleotide metabolic process	GO:0045981	114	0.010
heart morphogenesis	GO:0003007	178	0.010
organic hydroxy compound biosynthetic process	GO:1901617	77	0.010
lateral inhibition	GO:0046331	1	0.010
positive regulation of gtpase activity	GO:0043547	85	0.010
anion transport	GO:0006820	177	0.010
protein targeting to lysosome	GO:0006622	2	0.010

Hps6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.033
disease of anatomical entity	DOID:7	0.033
immune system disease	DOID:2914	0.021
sensory system disease	DOID:0050155	0.016
eye disease	DOID:5614	0.014
eye and adnexa disease	DOID:1492	0.014
disease of metabolism	DOID:0014667	0.013
musculoskeletal system disease	DOID:17	0.012
connective tissue disease	DOID:65	0.010
bone disease	DOID:0080001	0.010
neuromuscular disease	DOID:440	0.010
neuropathy	DOID:870	0.010

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