IMP: Integrative Multi-species Prediction

Mus musculus

221 known processes

Ins2

insulin II

(Aliases: Mody,InsII,Ins-2,AA986540,Mody4,proinsulin)

Entrez: 16334
Ensembl: ENSMUSG00000000215
UniProtKB: Q5EEX1
UniProtKB: P01326

Process Predictions
Disease Predictions

Ins2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
exocrine pancreas development	GO:0031017	7	0.983	Mouse
regulation of feeding behavior	GO:0060259	3	0.937	Zebrafish
glucose metabolic process	GO:0006006	92	0.891
cellular amino acid metabolic process	GO:0006520	103	0.858
cellular response to peptide	GO:1901653	92	0.766
positive regulation of lipid kinase activity	GO:0090218	11	0.755
inflammatory response	GO:0006954	244	0.731
regulation of cellular amine metabolic process	GO:0033238	20	0.724
cellular amine metabolic process	GO:0044106	44	0.666
cellular glucan metabolic process	GO:0006073	32	0.655	Mouse
oxidation reduction process	GO:0055114	342	0.627	Mouse
water homeostasis	GO:0030104	27	0.619	Mouse
peptidyl amino acid modification	GO:0018193	336	0.595
positive regulation of mapk cascade	GO:0043410	170	0.594
gland development	GO:0048732	330	0.591	Mouse
positive regulation of kinase activity	GO:0033674	155	0.561
urogenital system development	GO:0001655	261	0.552	Mouse
response to peptide	GO:1901652	136	0.551
regulation of kinase activity	GO:0043549	249	0.518
circadian rhythm	GO:0007623	114	0.495	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.495	Mouse
regulation of glycogen metabolic process	GO:0070873	13	0.476	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.474
exocrine system development	GO:0035272	45	0.471	Mouse
amine metabolic process	GO:0009308	45	0.456
regulation of polysaccharide metabolic process	GO:0032881	13	0.452	Mouse
carbohydrate metabolic process	GO:0005975	230	0.452
regulation of cellular ketone metabolic process	GO:0010565	66	0.451
regulation of response to wounding	GO:1903034	189	0.450
feeding behavior	GO:0007631	62	0.449	Zebrafish
fat cell differentiation	GO:0045444	160	0.442
hexose metabolic process	GO:0019318	98	0.428
phospholipid metabolic process	GO:0006644	87	0.413
lipid catabolic process	GO:0016042	69	0.412
cellular lipid metabolic process	GO:0044255	323	0.409
response to insulin	GO:0032868	100	0.390
regulation of inflammatory response	GO:0050727	147	0.381
circulatory system process	GO:0003013	197	0.372
positive regulation of lipid metabolic process	GO:0045834	40	0.371
forebrain development	GO:0030900	302	0.366
regulation of glucose metabolic process	GO:0010906	60	0.365	Mouse
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.364
regulation of lipid metabolic process	GO:0019216	118	0.356
hindbrain development	GO:0030902	128	0.354	Mouse
g protein coupled receptor signaling pathway	GO:0007186	243	0.349
carbohydrate derivative biosynthetic process	GO:1901137	183	0.347	Mouse
regulation of cell migration	GO:0030334	219	0.345
response to peptide hormone	GO:0043434	127	0.344
positive regulation of transferase activity	GO:0051347	167	0.334
positive regulation of map kinase activity	GO:0043406	84	0.333
regulation of carbohydrate metabolic process	GO:0006109	75	0.328	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.323
glycogen biosynthetic process	GO:0005978	14	0.322	Mouse
rhythmic process	GO:0048511	174	0.319	Mouse
response to monosaccharide	GO:0034284	67	0.316	Zebrafish
regulation of transferase activity	GO:0051338	263	0.313
blood circulation	GO:0008015	195	0.309
positive regulation of protein modification process	GO:0031401	299	0.306
regulation of cell motility	GO:2000145	236	0.304
regulation of fatty acid metabolic process	GO:0019217	28	0.302
cellular response to insulin stimulus	GO:0032869	78	0.299
response to organic cyclic compound	GO:0014070	198	0.299
positive regulation of insulin receptor signaling pathway	GO:0046628	4	0.297	Mouse
response to growth factor	GO:0070848	198	0.296
polysaccharide biosynthetic process	GO:0000271	20	0.294	Mouse
regulation of circadian sleep wake cycle	GO:0042749	3	0.290
negative regulation of phosphorylation	GO:0042326	166	0.289	Mouse
negative regulation of cellular component organization	GO:0051129	194	0.289	Mouse
activation of mapk activity	GO:0000187	59	0.287
glycoprotein biosynthetic process	GO:0009101	89	0.287	Mouse
regulation of protein kinase activity	GO:0045859	232	0.278
generation of precursor metabolites and energy	GO:0006091	103	0.278	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.278	Mouse
anatomical structure homeostasis	GO:0060249	145	0.276
cellular response to growth factor stimulus	GO:0071363	197	0.275
cellular ketone metabolic process	GO:0042180	84	0.271
locomotory behavior	GO:0007626	195	0.270
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.269	Mouse
polysaccharide metabolic process	GO:0005976	39	0.263	Mouse
regulation of circadian sleep wake cycle sleep	GO:0045187	3	0.243
positive regulation of insulin secretion	GO:0032024	26	0.240
extracellular structure organization	GO:0043062	148	0.238
erk1 and erk2 cascade	GO:0070371	77	0.233	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.230
organelle localization	GO:0051640	179	0.229
response to nutrient levels	GO:0031667	109	0.226	Zebrafish
insulin receptor signaling pathway	GO:0008286	49	0.226
proteoglycan biosynthetic process	GO:0030166	20	0.226	Mouse
response to endoplasmic reticulum stress	GO:0034976	53	0.223
telencephalon development	GO:0021537	186	0.223
prostate gland morphogenesis	GO:0060512	32	0.214	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.213
positive regulation of peptide hormone secretion	GO:0090277	31	0.213
cerebellar granule cell precursor proliferation	GO:0021930	10	0.212	Mouse
fertilization	GO:0009566	127	0.210
epithelial tube morphogenesis	GO:0060562	303	0.210	Mouse
digestive system development	GO:0055123	200	0.207	Mouse
cellular carbohydrate metabolic process	GO:0044262	119	0.201	Mouse
adult behavior	GO:0030534	135	0.198
establishment of organelle localization	GO:0051656	122	0.197
asymmetric stem cell division	GO:0098722	3	0.195
cellular response to organonitrogen compound	GO:0071417	145	0.192
response to organonitrogen compound	GO:0010243	246	0.191
regulation of generation of precursor metabolites and energy	GO:0043467	38	0.189	Mouse
ear development	GO:0043583	200	0.189	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.187	Mouse
negative regulation of response to wounding	GO:1903035	77	0.187
muscle cell differentiation	GO:0042692	261	0.186
connective tissue development	GO:0061448	179	0.184	Mouse
striated muscle tissue development	GO:0014706	293	0.184
monocarboxylic acid catabolic process	GO:0072329	27	0.181
positive regulation of leukocyte proliferation	GO:0070665	73	0.181
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.178
negative regulation of feeding behavior	GO:2000252	1	0.173	Zebrafish
insulin like growth factor receptor signaling pathway	GO:0048009	21	0.171	Mouse
monocarboxylic acid metabolic process	GO:0032787	191	0.171
regulation of androgen receptor signaling pathway	GO:0060765	3	0.169	Mouse
cell fate commitment	GO:0045165	210	0.168
organic hydroxy compound metabolic process	GO:1901615	203	0.167
neuron death	GO:0070997	154	0.165
negative regulation of phosphate metabolic process	GO:0045936	184	0.164	Mouse
camera type eye development	GO:0043010	266	0.164
negative regulation of phosphorus metabolic process	GO:0010563	184	0.163	Mouse
cellular response to hormone stimulus	GO:0032870	150	0.162
extracellular matrix organization	GO:0030198	147	0.162
renal system process	GO:0003014	48	0.160
negative regulation of protein metabolic process	GO:0051248	282	0.159
glucan metabolic process	GO:0044042	32	0.159	Mouse
embryonic placenta development	GO:0001892	98	0.156
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	14	0.155
blood vessel remodeling	GO:0001974	33	0.150	Mouse
release of cytochrome c from mitochondria	GO:0001836	23	0.150	Mouse
regulation of circadian rhythm	GO:0042752	58	0.147
positive regulation of neuron differentiation	GO:0045666	141	0.146
glucose import	GO:0046323	32	0.146
heart contraction	GO:0060047	93	0.144
glycogen metabolic process	GO:0005977	32	0.143	Mouse
apoptotic signaling pathway	GO:0097190	306	0.142
second messenger mediated signaling	GO:0019932	73	0.141
regulation of lipid kinase activity	GO:0043550	14	0.141
positive regulation of keratinocyte proliferation	GO:0010838	4	0.140
positive regulation of secretion by cell	GO:1903532	114	0.138
defense response to bacterium	GO:0042742	119	0.132
negative regulation of cell development	GO:0010721	169	0.131
cell adhesion	GO:0007155	329	0.128
chondroitin sulfate proteoglycan biosynthetic process	GO:0050650	8	0.127	Mouse
pancreas development	GO:0031016	57	0.125	Mouse
peptide secretion	GO:0002790	114	0.123
circadian sleep wake cycle	GO:0042745	5	0.122
organic hydroxy compound transport	GO:0015850	93	0.121
neuromuscular process	GO:0050905	99	0.120
positive regulation of phosphatidylinositol 3 kinase activity	GO:0043552	11	0.117
positive regulation of hormone secretion	GO:0046887	38	0.117
regulation of cell activation	GO:0050865	289	0.116
response to starvation	GO:0042594	65	0.116
regulation of anatomical structure size	GO:0090066	178	0.116
cytokine mediated signaling pathway	GO:0019221	115	0.112
response to extracellular stimulus	GO:0009991	127	0.111	Zebrafish
cellular polysaccharide metabolic process	GO:0044264	38	0.111	Mouse
intrinsic apoptotic signaling pathway	GO:0097193	132	0.110
lung epithelium development	GO:0060428	37	0.109	Mouse
negative regulation of release of cytochrome c from mitochondria	GO:0090201	6	0.109	Mouse
positive regulation of carbohydrate metabolic process	GO:0045913	30	0.109	Mouse
response to alkaloid	GO:0043279	34	0.108
fatty acid metabolic process	GO:0006631	121	0.108
developmental cell growth	GO:0048588	84	0.108
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	40	0.107
carbohydrate biosynthetic process	GO:0016051	74	0.106	Mouse
regulation of secretion	GO:0051046	274	0.106
t cell activation	GO:0042110	289	0.105
regulation of leukocyte differentiation	GO:1902105	159	0.105
lipid transport	GO:0006869	98	0.104
positive regulation of glycogen metabolic process	GO:0070875	8	0.104	Mouse
glucose homeostasis	GO:0042593	128	0.103
cell growth	GO:0016049	130	0.102
regulation of system process	GO:0044057	200	0.101
protein kinase b signaling	GO:0043491	74	0.100	Mouse
long term synaptic potentiation	GO:0060291	25	0.099
regulation of body fluid levels	GO:0050878	162	0.099
cellular chemical homeostasis	GO:0055082	215	0.099
lipid biosynthetic process	GO:0008610	179	0.099
response to purine containing compound	GO:0014074	28	0.097
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.097
peptidyl tyrosine phosphorylation	GO:0018108	143	0.097
defense response to other organism	GO:0098542	197	0.097
positive regulation of glycogen starch synthase activity	GO:2000467	4	0.097	Mouse
positive regulation of cell activation	GO:0050867	158	0.097
gliogenesis	GO:0042063	141	0.097	Mouse
cerebral cortex development	GO:0021987	86	0.094
positive regulation of calcium ion transport	GO:0051928	27	0.094
response to oxygen levels	GO:0070482	62	0.094
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.093
peptidyl tyrosine modification	GO:0018212	145	0.091
prostate gland epithelium morphogenesis	GO:0060740	31	0.090	Mouse
regulation of neuron differentiation	GO:0045664	281	0.090
positive regulation of cellular carbohydrate metabolic process	GO:0010676	29	0.089	Mouse
cell type specific apoptotic process	GO:0097285	268	0.088
multi multicellular organism process	GO:0044706	109	0.086
positive regulation of nervous system development	GO:0051962	221	0.086	Mouse
response to cocaine	GO:0042220	14	0.086
epithelial cell proliferation	GO:0050673	174	0.083
peptide transport	GO:0015833	133	0.083
germ cell development	GO:0007281	185	0.082
prostate gland stromal morphogenesis	GO:0060741	2	0.082	Mouse
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.082
regulation of hormone secretion	GO:0046883	88	0.082
positive regulation of t cell activation	GO:0050870	101	0.081
intracellular receptor signaling pathway	GO:0030522	74	0.081	Mouse
positive regulation of peptide secretion	GO:0002793	33	0.081
germline stem cell asymmetric division	GO:0098728	2	0.080
placenta development	GO:0001890	140	0.080
calcium mediated signaling	GO:0019722	46	0.079
organic anion transport	GO:0015711	137	0.079
eating behavior	GO:0042755	15	0.079
lipid localization	GO:0010876	126	0.079
positive regulation of cell development	GO:0010720	237	0.078
negative regulation of cellular protein metabolic process	GO:0032269	247	0.078
apoptotic mitochondrial changes	GO:0008637	48	0.078	Mouse
regulation of epithelial cell proliferation	GO:0050678	141	0.078
insulin secretion	GO:0030073	89	0.077
positive regulation of glucose metabolic process	GO:0010907	21	0.077	Mouse
regulation of mapk cascade	GO:0043408	248	0.077
positive regulation of glucose transport	GO:0010828	16	0.077
regulation of lymphocyte activation	GO:0051249	240	0.077
extrinsic apoptotic signaling pathway	GO:0097191	126	0.076	Mouse
positive regulation of lymphocyte activation	GO:0051251	140	0.075
regulation of lymphocyte differentiation	GO:0045619	107	0.075
epithelial cell migration	GO:0010631	63	0.074
energy derivation by oxidation of organic compounds	GO:0015980	77	0.074	Mouse
posttranscriptional regulation of gene expression	GO:0010608	155	0.073
spinal cord development	GO:0021510	81	0.073
mitochondrion organization	GO:0007005	134	0.073	Mouse
heart process	GO:0003015	94	0.073
cellular polysaccharide biosynthetic process	GO:0033692	19	0.073	Mouse
regulation of systemic arterial blood pressure	GO:0003073	61	0.073
response to ethanol	GO:0045471	18	0.072
somatotropin secreting cell differentiation	GO:0060126	4	0.072
ribonucleotide metabolic process	GO:0009259	291	0.072
cellular response to starvation	GO:0009267	57	0.071
monosaccharide metabolic process	GO:0005996	106	0.071
ventral spinal cord development	GO:0021517	48	0.069
regulation of multi organism process	GO:0043900	111	0.068
action potential	GO:0001508	78	0.068
male germ line stem cell asymmetric division	GO:0048133	2	0.068
regulation of secretion by cell	GO:1903530	249	0.068
regulation of wound healing	GO:0061041	40	0.067
regulation of hormone levels	GO:0010817	211	0.066
leukocyte migration	GO:0050900	124	0.066
transmission of nerve impulse	GO:0019226	76	0.066
digestion	GO:0007586	40	0.066
catecholamine metabolic process	GO:0006584	30	0.065
positive regulation of ion transmembrane transport	GO:0034767	24	0.065
axonogenesis	GO:0007409	274	0.065
exploration behavior	GO:0035640	21	0.065
regulation of vesicle mediated transport	GO:0060627	139	0.064
tissue homeostasis	GO:0001894	115	0.064
adult locomotory behavior	GO:0008344	91	0.064
regulation of glucan biosynthetic process	GO:0010962	7	0.063	Mouse
regulation of blood circulation	GO:1903522	93	0.061
multicellular organism growth	GO:0035264	161	0.060	Mouse
nitrogen compound transport	GO:0071705	271	0.060
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.060
monosaccharide transport	GO:0015749	58	0.060
type ii pneumocyte differentiation	GO:0060510	7	0.059	Mouse
response to alkaline ph	GO:0010446	1	0.059
regulation of defense response	GO:0031347	233	0.059
myeloid cell differentiation	GO:0030099	233	0.059
regulation of polysaccharide biosynthetic process	GO:0032885	7	0.059	Mouse
carbohydrate homeostasis	GO:0033500	128	0.059
regulation of cellular response to stress	GO:0080135	159	0.058
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.058	Mouse
prostate gland growth	GO:0060736	13	0.058	Mouse
negative regulation of cytokine production	GO:0001818	84	0.057
organic acid catabolic process	GO:0016054	51	0.057
divalent metal ion transport	GO:0070838	172	0.057
positive regulation of lymphocyte proliferation	GO:0050671	70	0.057
lactation	GO:0007595	25	0.057
cellular response to abiotic stimulus	GO:0071214	56	0.057
response to radiation	GO:0009314	165	0.056
amide transport	GO:0042886	138	0.056
negative regulation of intracellular steroid hormone receptor signaling pathway	GO:0033144	11	0.056	Mouse
negative regulation of neuron apoptotic process	GO:0043524	92	0.055
negative regulation of androgen receptor signaling pathway	GO:0060766	3	0.055	Mouse
organ growth	GO:0035265	117	0.054	Mouse
striated muscle contraction	GO:0006941	45	0.054
type i pneumocyte differentiation	GO:0060509	7	0.054	Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.054
diencephalon development	GO:0021536	63	0.054
hippocampus development	GO:0021766	52	0.054
response to drug	GO:0042493	75	0.054
ameboidal type cell migration	GO:0001667	128	0.054
cell chemotaxis	GO:0060326	81	0.054
pigment granule localization	GO:0051875	13	0.054
learning or memory	GO:0007611	148	0.053
inner ear morphogenesis	GO:0042472	101	0.053
activation of transmembrane receptor protein tyrosine kinase activity	GO:0007171	3	0.053
carboxylic acid catabolic process	GO:0046395	51	0.053
regulation of metal ion transport	GO:0010959	106	0.053
establishment of melanosome localization	GO:0032401	11	0.052
cation transport	GO:0006812	399	0.052
regulation of keratinocyte differentiation	GO:0045616	11	0.052
sulfur compound metabolic process	GO:0006790	100	0.051	Mouse
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.051
regulation of glycogen starch synthase activity	GO:2000465	5	0.051	Mouse
neuron migration	GO:0001764	122	0.051
positive regulation of cell migration	GO:0030335	109	0.051
cellular response to peptide hormone stimulus	GO:0071375	92	0.050
inositol lipid mediated signaling	GO:0048017	41	0.050	Mouse
glycerolipid metabolic process	GO:0046486	122	0.050
protein oligomerization	GO:0051259	67	0.049
response to inorganic substance	GO:0010035	96	0.049
epithelial cell development	GO:0002064	159	0.049
cell differentiation in spinal cord	GO:0021515	53	0.049
cation transmembrane transport	GO:0098655	266	0.049
response to testosterone	GO:0033574	3	0.049
positive regulation of cellular catabolic process	GO:0031331	148	0.049
neuron projection guidance	GO:0097485	141	0.048
purine nucleotide metabolic process	GO:0006163	302	0.048
cardiac ventricle development	GO:0003231	83	0.048
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.048
multicellular organismal homeostasis	GO:0048871	164	0.048
multicellular organismal response to stress	GO:0033555	62	0.047
phenol containing compound biosynthetic process	GO:0046189	21	0.047
negative regulation of epithelial cell proliferation	GO:0050680	64	0.047
tissue migration	GO:0090130	68	0.047
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.047
negative regulation of defense response	GO:0031348	77	0.047
ribonucleotide biosynthetic process	GO:0009260	59	0.047
sensory organ morphogenesis	GO:0090596	242	0.047
positive regulation of inner ear receptor cell differentiation	GO:2000982	1	0.046
regulation of transmembrane transport	GO:0034762	128	0.046
sodium ion transport	GO:0006814	73	0.046
nucleoside phosphate metabolic process	GO:0006753	338	0.046
myotube differentiation	GO:0014902	105	0.046
blood vessel morphogenesis	GO:0048514	285	0.045
regulation of organ growth	GO:0046620	61	0.045
regulation of cellular component biogenesis	GO:0044087	181	0.045
positive regulation of secretion	GO:0051047	130	0.045
regulation of myoblast proliferation	GO:2000291	8	0.045	Mouse
divalent inorganic cation transport	GO:0072511	178	0.045
negative regulation of transferase activity	GO:0051348	85	0.045
neuron apoptotic process	GO:0051402	142	0.045
glycerolipid biosynthetic process	GO:0045017	50	0.045
maintenance of location	GO:0051235	89	0.044
nucleoside monophosphate metabolic process	GO:0009123	85	0.044
spermatogenesis	GO:0007283	284	0.044
regulation of peptide transport	GO:0090087	91	0.044
glucan biosynthetic process	GO:0009250	14	0.044	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.044	Mouse
positive regulation of homeostatic process	GO:0032846	64	0.044
regulation of t cell activation	GO:0050863	170	0.044
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.044
regulation of cell cycle	GO:0051726	281	0.044
chondroitin sulfate proteoglycan metabolic process	GO:0050654	20	0.043	Mouse
cartilage development	GO:0051216	140	0.043
positive regulation of protein kinase activity	GO:0045860	144	0.043
pancreatic a cell fate commitment	GO:0003326	2	0.043
response to transforming growth factor beta	GO:0071559	88	0.042
establishment of protein localization to organelle	GO:0072594	118	0.042
response to decreased oxygen levels	GO:0036293	59	0.042
cellular nitrogen compound catabolic process	GO:0044270	280	0.042
transmembrane transport	GO:0055085	412	0.042
fatty acid oxidation	GO:0019395	28	0.042
catecholamine transport	GO:0051937	21	0.042
cellular protein complex assembly	GO:0043623	116	0.041
covalent chromatin modification	GO:0016569	163	0.041
single fertilization	GO:0007338	82	0.040
purine nucleoside metabolic process	GO:0042278	241	0.040
jak stat cascade	GO:0007259	42	0.040
cellular lipid catabolic process	GO:0044242	52	0.040
auditory receptor cell fate specification	GO:0042667	1	0.040
atp metabolic process	GO:0046034	75	0.039
single organism cell adhesion	GO:0098602	156	0.039
regulation of auditory receptor cell differentiation	GO:0045607	4	0.039
peptide hormone secretion	GO:0030072	109	0.039
positive regulation of blood circulation	GO:1903524	22	0.039
chromatin organization	GO:0006325	206	0.039
mating	GO:0007618	27	0.039
regulation of ion transport	GO:0043269	215	0.039
vasodilation	GO:0042311	28	0.039
negative regulation of cellular amine metabolic process	GO:0033239	1	0.039
organophosphate biosynthetic process	GO:0090407	122	0.038
positive regulation of programmed cell death	GO:0043068	218	0.038
nitric oxide mediated signal transduction	GO:0007263	4	0.038
adrenergic receptor signaling pathway	GO:0071875	13	0.038
glycosaminoglycan biosynthetic process	GO:0006024	15	0.038	Mouse
syncytium formation by plasma membrane fusion	GO:0000768	42	0.038
monoamine transport	GO:0015844	33	0.038
single organismal cell cell adhesion	GO:0016337	131	0.038
b cell proliferation	GO:0042100	53	0.037
hormone secretion	GO:0046879	128	0.037
prostate gland development	GO:0030850	48	0.037	Mouse
regulation of glycogen biosynthetic process	GO:0005979	7	0.037	Mouse
cellular glucose homeostasis	GO:0001678	52	0.037
calcium ion transmembrane transport	GO:0070588	85	0.037
visual learning	GO:0008542	44	0.037
carbohydrate transport	GO:0008643	62	0.036
multicellular organismal water homeostasis	GO:0050891	23	0.036
cardiocyte differentiation	GO:0035051	87	0.036
negative regulation of inflammatory response	GO:0050728	61	0.036
positive regulation of glycolytic process	GO:0045821	4	0.036
purine containing compound metabolic process	GO:0072521	311	0.036
negative regulation of cell migration	GO:0030336	59	0.036
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.036
regulation of blood pressure	GO:0008217	93	0.036
positive regulation of cerebellar granule cell precursor proliferation	GO:0021940	10	0.036	Mouse
regulation of insulin receptor signaling pathway	GO:0046626	21	0.035	Mouse
lateral line system development	GO:0048925	1	0.035
negative regulation of rho protein signal transduction	GO:0035024	7	0.035
hexose transport	GO:0008645	56	0.035
negative regulation of mapk cascade	GO:0043409	65	0.035	Mouse
negative regulation of nervous system development	GO:0051961	156	0.035
signal transduction in absence of ligand	GO:0038034	55	0.035	Mouse
regulation of peptide hormone secretion	GO:0090276	75	0.035
negative regulation of type b pancreatic cell apoptotic process	GO:2000675	3	0.035
response to nicotine	GO:0035094	6	0.034
response to corticosterone	GO:0051412	1	0.034
cellular response to external stimulus	GO:0071496	88	0.034
regulation of transcription involved in cell fate commitment	GO:0060850	15	0.034
insulin receptor signaling pathway via phosphatidylinositol 3 kinase	GO:0038028	3	0.034	Mouse
regulation of blood vessel size	GO:0050880	56	0.034
cellular metal ion homeostasis	GO:0006875	151	0.034
regulation of water loss via skin	GO:0033561	16	0.034
nucleoside metabolic process	GO:0009116	246	0.034
negative regulation of epidermal cell differentiation	GO:0045605	7	0.034
regulation of neuron projection development	GO:0010975	169	0.034
macromolecule catabolic process	GO:0009057	281	0.034
cerebral cortex neuron differentiation	GO:0021895	19	0.034
regulation of ion transmembrane transport	GO:0034765	119	0.033
intestinal absorption	GO:0050892	13	0.033
forebrain neuron differentiation	GO:0021879	52	0.033
corticosterone secretion	GO:0035934	3	0.033
astrocyte fate commitment	GO:0060018	4	0.033
pallium development	GO:0021543	120	0.033
germ line stem cell division	GO:0042078	2	0.033
negative regulation of molecular function	GO:0044092	258	0.033
myeloid leukocyte activation	GO:0002274	83	0.033
positive regulation of voltage gated calcium channel activity	GO:1901387	2	0.033
regulation of neuron death	GO:1901214	134	0.033
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.033
regulation of circadian sleep wake cycle rem sleep	GO:0042320	1	0.033
reactive nitrogen species metabolic process	GO:2001057	0	0.033
cyclic purine nucleotide metabolic process	GO:0052652	43	0.033
synaptic transmission	GO:0007268	329	0.032
skin development	GO:0043588	220	0.032
limbic system development	GO:0021761	72	0.032
cognition	GO:0050890	149	0.032
vascular process in circulatory system	GO:0003018	62	0.032
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.032
adult feeding behavior	GO:0008343	9	0.032
negative regulation of mitochondrion organization	GO:0010823	9	0.032	Mouse
muscle contraction	GO:0006936	101	0.032
kidney development	GO:0001822	213	0.032
regulation of embryonic development	GO:0045995	71	0.032
regulation of protein serine threonine kinase activity	GO:0071900	157	0.032
pituitary gland development	GO:0021983	38	0.032
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.032
regulation of b cell proliferation	GO:0030888	39	0.032
negative regulation of protein phosphorylation	GO:0001933	126	0.032
respiratory system development	GO:0060541	190	0.031	Mouse
positive regulation of sodium ion transmembrane transport	GO:1902307	4	0.031
regulation of purine nucleotide metabolic process	GO:1900542	169	0.031
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	GO:0060527	7	0.031	Mouse
response to acid chemical	GO:0001101	111	0.031
defense response to virus	GO:0051607	68	0.031
cell substrate adhesion	GO:0031589	130	0.031
cytokine production	GO:0001816	319	0.031
skeletal muscle organ development	GO:0060538	163	0.031
intestinal cholesterol absorption	GO:0030299	5	0.031
glycoprotein metabolic process	GO:0009100	116	0.031	Mouse
regulation of acetylcholine secretion neurotransmission	GO:0014056	2	0.031
heterocycle catabolic process	GO:0046700	280	0.031
ribonucleoside metabolic process	GO:0009119	245	0.031
endomembrane system organization	GO:0010256	147	0.031
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.031
pancreatic pp cell fate commitment	GO:0003329	2	0.031
wnt signaling pathway	GO:0016055	188	0.031
regulation of homeostatic process	GO:0032844	182	0.030
multicellular organismal signaling	GO:0035637	91	0.030
metal ion homeostasis	GO:0055065	189	0.030
reactive oxygen species metabolic process	GO:0072593	84	0.030
regulation of membrane potential	GO:0042391	192	0.030
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.030	Mouse
regulation of glucose import	GO:0046324	26	0.030
regulation of intestinal cholesterol absorption	GO:0030300	4	0.030
regulation of cell adhesion	GO:0030155	154	0.030
cell maturation	GO:0048469	127	0.030
forebrain generation of neurons	GO:0021872	63	0.030
regulation of norepinephrine secretion	GO:0014061	2	0.030

Ins2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.647
diabetes mellitus	DOID:9351	0.360
type 2 diabetes mellitus	DOID:9352	0.360
carbohydrate metabolism disease	DOID:0050013	0.360
glucose metabolism disease	DOID:4194	0.360
acquired metabolic disease	DOID:0060158	0.360
inherited metabolic disorder	DOID:655	0.045

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network