IMP: Integrative Multi-species Prediction

Mus musculus

224 known processes

Irf1

interferon regulatory factor 1

(Aliases: Irf-1,AU020929)

Entrez: 16362
Ensembl: ENSMUSG00000018899
UniProtKB: Q5SX13
UniProtKB: Q3U5M1
UniProtKB: P15314

Process Predictions
Disease Predictions

Irf1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular response to molecule of bacterial origin	GO:0071219	83	0.971	Mouse
regulation of defense response	GO:0031347	233	0.959
interspecies interaction between organisms	GO:0044419	83	0.954	Mouse
defense response to other organism	GO:0098542	197	0.946
defense response to bacterium	GO:0042742	119	0.937	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.920
cellular response to cytokine stimulus	GO:0071345	189	0.911
innate immune response	GO:0045087	157	0.910
negative regulation of immune system process	GO:0002683	209	0.877
positive regulation of innate immune response	GO:0045089	80	0.877
regulation of defense response to virus by host	GO:0050691	8	0.857	Mouse
regulation of cytokine production	GO:0001817	266	0.850
negative regulation of interleukin 2 production	GO:0032703	8	0.841
regulation of innate immune response	GO:0045088	91	0.823
cellular amine metabolic process	GO:0044106	44	0.821
defense response to virus	GO:0051607	68	0.810
cellular response to lipopolysaccharide	GO:0071222	77	0.810	Mouse
response to lipopolysaccharide	GO:0032496	128	0.807	Mouse
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.803	Mouse
amine metabolic process	GO:0009308	45	0.803
negative regulation of multi organism process	GO:0043901	68	0.801	Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.770	Mouse
defense response to gram negative bacterium	GO:0050829	28	0.764
defense response to gram positive bacterium	GO:0050830	50	0.744
adaptive immune response	GO:0002250	155	0.733	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.731
negative regulation of protein metabolic process	GO:0051248	282	0.707	Mouse
t helper cell differentiation	GO:0042093	28	0.704	Mouse
antibacterial peptide production	GO:0002778	2	0.704
leukocyte differentiation	GO:0002521	342	0.702
response to protozoan	GO:0001562	28	0.698	Mouse
response to type i interferon	GO:0034340	12	0.697	Mouse
cellular response to dna damage stimulus	GO:0006974	207	0.692
defense response to protozoan	GO:0042832	25	0.687	Mouse
negative regulation of molecular function	GO:0044092	258	0.686
immune response regulating signaling pathway	GO:0002764	125	0.682
protein modification by small protein conjugation or removal	GO:0070647	207	0.681
cellular response to organonitrogen compound	GO:0071417	145	0.669
response to molecule of bacterial origin	GO:0002237	143	0.664	Mouse
negative regulation of defense response	GO:0031348	77	0.659	Mouse
peptidyl amino acid modification	GO:0018193	336	0.659	Mouse
antigen processing and presentation	GO:0019882	47	0.649
cellular response to lipid	GO:0071396	145	0.647	Mouse
t cell differentiation	GO:0030217	174	0.640
negative regulation of cell proliferation	GO:0008285	296	0.640	Mouse
regulation of tolerance induction dependent upon immune response	GO:0002652	1	0.637
protein ubiquitination	GO:0016567	171	0.619
regulation of defense response to bacterium	GO:1900424	3	0.614
inflammatory response	GO:0006954	244	0.612
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.599	Mouse
negative regulation of protein modification process	GO:0031400	163	0.596
regulation of interleukin 2 production	GO:0032663	28	0.587
immune effector process	GO:0002252	321	0.576
cytokine production	GO:0001816	319	0.571
negative regulation of cell activation	GO:0050866	111	0.569
cytokine mediated signaling pathway	GO:0019221	115	0.551
regulation of cytokine biosynthetic process	GO:0042035	59	0.544
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.543
negative regulation of lymphocyte activation	GO:0051250	91	0.541
response to interferon gamma	GO:0034341	34	0.525
pattern recognition receptor signaling pathway	GO:0002221	47	0.523
regulation of t cell mediated immunity	GO:0002709	34	0.518
positive regulation of adaptive immune response	GO:0002821	61	0.512
i kappab kinase nf kappab signaling	GO:0007249	85	0.500
immunoglobulin mediated immune response	GO:0016064	69	0.497	Mouse
production of molecular mediator of immune response	GO:0002440	103	0.483
regulation of adaptive immune response	GO:0002819	90	0.478
negative regulation of cytokine production	GO:0001818	84	0.477	Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.471
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.463	Mouse
antimicrobial peptide production	GO:0002775	2	0.462
positive regulation of apoptotic process	GO:0043065	217	0.461
interleukin 1 beta production	GO:0032611	30	0.457
carbohydrate derivative catabolic process	GO:1901136	231	0.455
regulation of cellular catabolic process	GO:0031329	242	0.440
peptidyl tyrosine phosphorylation	GO:0018108	143	0.431
regulation of leukocyte differentiation	GO:1902105	159	0.429
regulation of cellular amino acid metabolic process	GO:0006521	5	0.423
positive regulation of peptidase activity	GO:0010952	49	0.422
regulation of myd88 independent toll like receptor signaling pathway	GO:0034127	1	0.422	Mouse
lymphocyte activation involved in immune response	GO:0002285	93	0.421	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.409
positive regulation of cell death	GO:0010942	224	0.394
gland development	GO:0048732	330	0.394	Mouse
guanosine containing compound catabolic process	GO:1901069	144	0.387
regulation of lymphocyte mediated immunity	GO:0002706	84	0.386
heterocycle catabolic process	GO:0046700	280	0.385
cellular ketone metabolic process	GO:0042180	84	0.379
regulation of cytokine secretion	GO:0050707	61	0.376
glycosyl compound catabolic process	GO:1901658	206	0.374
regulation of antimicrobial humoral response	GO:0002759	3	0.367
negative regulation of t cell activation	GO:0050868	65	0.366
aromatic compound catabolic process	GO:0019439	286	0.365
regulation of t cell activation	GO:0050863	170	0.362
b cell activation	GO:0042113	161	0.362
negative regulation of immune effector process	GO:0002698	55	0.360	Mouse
negative regulation of natural killer cell mediated immunity	GO:0002716	5	0.353
activation of innate immune response	GO:0002218	56	0.349
negative regulation of protein phosphorylation	GO:0001933	126	0.343
regulation of lymphocyte proliferation	GO:0050670	117	0.338
positive regulation of programmed cell death	GO:0043068	218	0.336
purine ribonucleoside catabolic process	GO:0046130	205	0.328
cellular amide metabolic process	GO:0043603	58	0.327
t cell mediated immunity	GO:0002456	50	0.327
regulation of response to wounding	GO:1903034	189	0.321
regulation of interferon gamma production	GO:0032649	57	0.318	Mouse
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.317
positive regulation of defense response	GO:0031349	124	0.316
gtp metabolic process	GO:0046039	144	0.314
lymphocyte mediated immunity	GO:0002449	139	0.314	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.310
positive regulation of cytokine production	GO:0001819	174	0.308
positive regulation of immune effector process	GO:0002699	107	0.302
leukocyte proliferation	GO:0070661	172	0.302
t cell proliferation	GO:0042098	120	0.300
positive regulation of hydrolase activity	GO:0051345	148	0.300
negative regulation of phosphorus metabolic process	GO:0010563	184	0.297
cellular response to interferon gamma	GO:0071346	25	0.294
leukocyte chemotaxis	GO:0030595	69	0.293
viral process	GO:0016032	41	0.291
epithelial cell proliferation	GO:0050673	174	0.288	Mouse
humoral immune response	GO:0006959	57	0.286
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.282
regulation of t cell proliferation	GO:0042129	92	0.281
regulation of response to biotic stimulus	GO:0002831	38	0.277	Mouse
regulation of type i interferon mediated signaling pathway	GO:0060338	7	0.274	Mouse
lymphocyte proliferation	GO:0046651	164	0.269
myeloid cell differentiation	GO:0030099	233	0.268	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.267
regulation of lymphocyte activation	GO:0051249	240	0.264
t cell activation	GO:0042110	289	0.263
positive regulation of interferon gamma production	GO:0032729	39	0.256	Mouse
leukocyte activation involved in immune response	GO:0002366	126	0.256	Mouse
cytokine metabolic process	GO:0042107	71	0.256
negative regulation of inflammatory response	GO:0050728	61	0.255
glycosyl compound metabolic process	GO:1901657	246	0.254
interleukin 1 production	GO:0032612	31	0.254
peptidyl tyrosine modification	GO:0018212	145	0.252
type i interferon signaling pathway	GO:0060337	10	0.250	Mouse
homeostasis of number of cells	GO:0048872	210	0.250
antimicrobial peptide biosynthetic process	GO:0002777	2	0.249
negative regulation of growth	GO:0045926	99	0.248	Mouse
positive regulation of t cell mediated cytotoxicity	GO:0001916	15	0.247
reactive oxygen species metabolic process	GO:0072593	84	0.245
negative regulation of growth of symbiont in host	GO:0044130	19	0.245	Mouse
t cell activation involved in immune response	GO:0002286	43	0.241	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.241
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.240
cell activation involved in immune response	GO:0002263	126	0.240	Mouse
regulation of defense response to virus	GO:0050688	18	0.237	Mouse
positive regulation of interleukin 1 secretion	GO:0050716	14	0.237
ribose phosphate metabolic process	GO:0019693	291	0.234
immune response activating signal transduction	GO:0002757	116	0.234
cellular response to tumor necrosis factor	GO:0071356	21	0.234
viral life cycle	GO:0019058	36	0.230
antibacterial peptide biosynthetic process	GO:0002780	2	0.221
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.220
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.218	Mouse
nucleotide metabolic process	GO:0009117	332	0.216
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.215
macromolecule catabolic process	GO:0009057	281	0.215
positive regulation of protein modification process	GO:0031401	299	0.214
negative regulation of innate immune response	GO:0045824	17	0.214
alpha beta t cell activation involved in immune response	GO:0002287	31	0.211	Mouse
positive regulation of proteolysis	GO:0045862	85	0.208
regulation of autophagy	GO:0010506	30	0.204
b cell activation involved in immune response	GO:0002312	50	0.202
cellular response to biotic stimulus	GO:0071216	92	0.201	Mouse
t helper 1 type immune response	GO:0042088	25	0.198
muscle cell development	GO:0055001	133	0.197
programmed necrotic cell death	GO:0097300	28	0.194	Mouse
nucleoside triphosphate metabolic process	GO:0009141	230	0.193
lymphocyte differentiation	GO:0030098	242	0.192
protein localization to nucleus	GO:0034504	121	0.192
positive regulation of antimicrobial peptide production	GO:0002225	1	0.190
nucleotide catabolic process	GO:0009166	217	0.186
cytokine biosynthetic process	GO:0042089	68	0.185
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.184
negative regulation of phosphorylation	GO:0042326	166	0.183
antibacterial humoral response	GO:0019731	8	0.181
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway	GO:0002484	3	0.181
somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	36	0.178
somatic diversification of immunoglobulins	GO:0016445	43	0.175
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.175
small gtpase mediated signal transduction	GO:0007264	97	0.172
regulation of cell migration	GO:0030334	219	0.172
interferon gamma production	GO:0032609	67	0.171	Mouse
cytokine secretion	GO:0050663	72	0.171
organonitrogen compound catabolic process	GO:1901565	264	0.170
regulation of endopeptidase activity	GO:0052548	89	0.170
cellular response to type i interferon	GO:0071357	10	0.168	Mouse
cellular macromolecule catabolic process	GO:0044265	206	0.168
purine nucleotide catabolic process	GO:0006195	211	0.168
response to radiation	GO:0009314	165	0.167
regulation of cellular component biogenesis	GO:0044087	181	0.166	Mouse
negative regulation of cellular amine metabolic process	GO:0033239	1	0.166
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.163
regulation of epithelial cell proliferation	GO:0050678	141	0.163
regulation of leukocyte mediated immunity	GO:0002703	104	0.160
nucleoside phosphate catabolic process	GO:1901292	222	0.160
peptide metabolic process	GO:0006518	46	0.160
gtp catabolic process	GO:0006184	143	0.158
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.157
myeloid leukocyte differentiation	GO:0002573	119	0.155	Mouse
guanosine containing compound metabolic process	GO:1901068	144	0.154
regulation of natural killer cell mediated cytotoxicity	GO:0042269	19	0.153
response to organic cyclic compound	GO:0014070	198	0.153	Mouse
innate immune response activating signal transduction	GO:0002758	50	0.152
skin development	GO:0043588	220	0.152	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.151
regulation of cell motility	GO:2000145	236	0.150
negative regulation of cellular protein metabolic process	GO:0032269	247	0.150
cellular response to organic cyclic compound	GO:0071407	87	0.150
negative regulation of t helper 2 cell differentiation	GO:0045629	4	0.149
ras protein signal transduction	GO:0007265	77	0.148
carbohydrate metabolic process	GO:0005975	230	0.148
nucleobase containing small molecule metabolic process	GO:0055086	352	0.148
cellular nitrogen compound catabolic process	GO:0044270	280	0.148
response to tumor necrosis factor	GO:0034612	26	0.147
protein maturation	GO:0051604	176	0.146
dna metabolic process	GO:0006259	303	0.146
notch signaling pathway	GO:0007219	71	0.146
organophosphate catabolic process	GO:0046434	232	0.145
negative regulation of phosphate metabolic process	GO:0045936	184	0.144
regulation of cd4 positive alpha beta t cell activation	GO:2000514	24	0.142
forebrain development	GO:0030900	302	0.140
regulation of protein ubiquitination	GO:0031396	52	0.140
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.139
purine containing compound catabolic process	GO:0072523	213	0.138
organic cyclic compound catabolic process	GO:1901361	295	0.137
positive regulation of t helper 1 cell differentiation	GO:0045627	4	0.136
regulation of toll like receptor signaling pathway	GO:0034121	20	0.133
cytoplasmic transport	GO:0016482	234	0.133
regulation of antibacterial peptide biosynthetic process	GO:0002808	1	0.133
autophagy	GO:0006914	45	0.132
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.130
organonitrogen compound biosynthetic process	GO:1901566	192	0.129
regulation of lipid metabolic process	GO:0019216	118	0.128
response to organonitrogen compound	GO:0010243	246	0.126
purine ribonucleotide catabolic process	GO:0009154	208	0.126
regulation of interleukin 1 beta production	GO:0032651	25	0.126
alpha beta t cell activation	GO:0046631	91	0.125
negative regulation of response to wounding	GO:1903035	77	0.125
germ cell development	GO:0007281	185	0.124
purine ribonucleoside metabolic process	GO:0046128	241	0.121
chemotaxis	GO:0006935	247	0.120
negative regulation of nervous system development	GO:0051961	156	0.120
histone modification	GO:0016570	159	0.120	Mouse
negative regulation of cell cycle	GO:0045786	123	0.119	Human
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.119
cytoplasmic pattern recognition receptor signaling pathway	GO:0002753	10	0.119
blood vessel morphogenesis	GO:0048514	285	0.118
regulation of interleukin 1 production	GO:0032652	26	0.118
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.118
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.115
cd4 positive alpha beta t cell activation	GO:0035710	45	0.114	Mouse
regulation of acute inflammatory response	GO:0002673	27	0.114
nik nf kappab signaling	GO:0038061	14	0.114
cellular response to hormone stimulus	GO:0032870	150	0.113
ribonucleoside metabolic process	GO:0009119	245	0.113
nucleotide binding oligomerization domain containing signaling pathway	GO:0070423	6	0.113
positive regulation of interleukin 12 production	GO:0032735	21	0.112
negative regulation of myeloid cell differentiation	GO:0045638	38	0.111
ribonucleoside catabolic process	GO:0042454	206	0.111
negative regulation of t cell proliferation	GO:0042130	38	0.111
regulation of protein kinase activity	GO:0045859	232	0.110
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.109
response to amino acid	GO:0043200	37	0.109
purine nucleoside catabolic process	GO:0006152	205	0.108
protein catabolic process	GO:0030163	221	0.107
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.105
dna recombination	GO:0006310	92	0.105
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.105
b cell mediated immunity	GO:0019724	71	0.105	Mouse
cd4 positive or cd8 positive alpha beta t cell lineage commitment	GO:0043369	8	0.104	Mouse
regulation of cytoplasmic transport	GO:1903649	112	0.104
immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	43	0.101
regulation of interleukin 1 beta secretion	GO:0050706	15	0.101
response to oxygen levels	GO:0070482	62	0.100
t cell differentiation involved in immune response	GO:0002292	30	0.099	Mouse
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	1	0.099
regulation of type 2 immune response	GO:0002828	18	0.099
regulation of inflammatory response	GO:0050727	147	0.098
regulation of protein localization	GO:0032880	231	0.098
intracellular receptor signaling pathway	GO:0030522	74	0.096
toll like receptor signaling pathway	GO:0002224	38	0.096
regulation of kinase activity	GO:0043549	249	0.094
regulation of interleukin 1 secretion	GO:0050704	15	0.094
regulation of protein transport	GO:0051223	163	0.093
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.092
isotype switching	GO:0045190	36	0.092
body morphogenesis	GO:0010171	45	0.091
regulation of secretion	GO:0051046	274	0.091
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.091
myeloid dendritic cell differentiation	GO:0043011	16	0.091	Mouse
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.091
ribonucleotide metabolic process	GO:0009259	291	0.091
negative regulation of transferase activity	GO:0051348	85	0.090
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.089
angiogenesis	GO:0001525	201	0.088
morphogenesis of a branching structure	GO:0001763	203	0.087
interleukin 1 beta secretion	GO:0050702	16	0.087
regulation of hydrolase activity	GO:0051336	246	0.087
regulation of transferase activity	GO:0051338	263	0.087
ossification	GO:0001503	216	0.086
gonad development	GO:0008406	141	0.086
extrinsic apoptotic signaling pathway	GO:0097191	126	0.086
regulation of proteolysis	GO:0030162	164	0.086
negative regulation of intracellular signal transduction	GO:1902532	167	0.085
regulation of stem cell proliferation	GO:0072091	78	0.084
protein localization to organelle	GO:0033365	185	0.083
response to light stimulus	GO:0009416	135	0.083
regulation of interleukin 6 production	GO:0032675	55	0.082
tyrosine phosphorylation of stat1 protein	GO:0042508	3	0.082
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	34	0.081
leukocyte migration	GO:0050900	124	0.080
regulation of antimicrobial peptide production	GO:0002784	1	0.079
t cell differentiation in thymus	GO:0033077	77	0.078
regulation of multi organism process	GO:0043900	111	0.078	Mouse
response to peptide	GO:1901652	136	0.078
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.078
modification dependent protein catabolic process	GO:0019941	133	0.077
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.077
negative regulation of lymphocyte mediated immunity	GO:0002707	21	0.076
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.076
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.075
stem cell proliferation	GO:0072089	117	0.075
stem cell differentiation	GO:0048863	268	0.075
leukocyte apoptotic process	GO:0071887	71	0.074
epithelial tube morphogenesis	GO:0060562	303	0.074
regulation of intracellular transport	GO:0032386	159	0.074
positive regulation of cellular component biogenesis	GO:0044089	94	0.073	Mouse
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.072
regulation of antimicrobial peptide biosynthetic process	GO:0002805	1	0.072
negative regulation of leukocyte differentiation	GO:1902106	51	0.071
regulation of antibacterial peptide production	GO:0002786	1	0.071
rna interference	GO:0016246	2	0.071
female sex differentiation	GO:0046660	84	0.071
regulation of t cell differentiation	GO:0045580	83	0.071
positive regulation of tolerance induction dependent upon immune response	GO:0002654	1	0.071
positive regulation of protein phosphorylation	GO:0001934	242	0.071
positive regulation of rho gtpase activity	GO:0032321	41	0.071
regulation of leukocyte proliferation	GO:0070663	121	0.070
regulation of establishment of protein localization	GO:0070201	181	0.070
type i interferon production	GO:0032606	29	0.069
syncytium formation by plasma membrane fusion	GO:0000768	42	0.069
acute inflammatory response	GO:0002526	41	0.069
modulation by virus of host morphology or physiology	GO:0019048	3	0.068
regulation of t helper 1 cell differentiation	GO:0045625	7	0.068
purine nucleoside metabolic process	GO:0042278	241	0.068
negative regulation of cellular component organization	GO:0051129	194	0.067
regulation of tumor necrosis factor production	GO:0032680	49	0.067
regulation of ras protein signal transduction	GO:0046578	114	0.067
neural tube development	GO:0021915	160	0.067
cellular protein catabolic process	GO:0044257	155	0.066
regulation of b cell mediated immunity	GO:0002712	37	0.066
regulation of notch signaling pathway	GO:0008593	35	0.066
development of primary sexual characteristics	GO:0045137	143	0.066
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.066	Mouse
ubiquitin dependent protein catabolic process	GO:0006511	129	0.066
regulation of cell cycle	GO:0051726	281	0.065	Human
response to nicotine	GO:0035094	6	0.065
tumor necrosis factor production	GO:0032640	50	0.065
regulation of cytoskeleton organization	GO:0051493	122	0.065
regulation of striated muscle cell differentiation	GO:0051153	81	0.065
response to hypoxia	GO:0001666	58	0.065
negative regulation of toll like receptor signaling pathway	GO:0034122	14	0.064	Mouse
negative regulation of inflammatory response to antigenic stimulus	GO:0002862	10	0.063
regulation of apoptotic signaling pathway	GO:2001233	197	0.063
purine containing compound metabolic process	GO:0072521	311	0.063
positive regulation of leukocyte differentiation	GO:1902107	86	0.062
t helper 2 cell differentiation	GO:0045064	12	0.062
positive regulation of t cell activation	GO:0050870	101	0.062
alpha beta t cell differentiation	GO:0046632	69	0.062
stem cell maintenance	GO:0019827	130	0.062
interleukin 12 biosynthetic process	GO:0042090	8	0.061
positive regulation of response to cytokine stimulus	GO:0060760	11	0.061	Mouse
negative regulation of viral process	GO:0048525	23	0.060
necrotic cell death	GO:0070265	30	0.060	Mouse
mitotic cell cycle	GO:0000278	195	0.059
developmental maturation	GO:0021700	193	0.059
regionalization	GO:0003002	337	0.058
regulation of membrane potential	GO:0042391	192	0.058
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.058
regulation of alpha beta t cell activation	GO:0046634	53	0.058
nucleocytoplasmic transport	GO:0006913	139	0.058
type i interferon biosynthetic process	GO:0045351	9	0.058	Mouse
dendritic cell differentiation	GO:0097028	26	0.058	Mouse
nucleoside metabolic process	GO:0009116	246	0.057
purine ribonucleotide metabolic process	GO:0009150	290	0.057
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.057
response to inorganic substance	GO:0010035	96	0.057
positive regulation of antigen processing and presentation	GO:0002579	10	0.057
negative regulation of cell development	GO:0010721	169	0.057
keratinocyte differentiation	GO:0030216	48	0.056	Mouse
somatic diversification of immune receptors	GO:0002200	53	0.056
cd8 positive alpha beta t cell proliferation	GO:0035740	1	0.056
regulation of necroptotic process	GO:0060544	10	0.056
amide transport	GO:0042886	138	0.054
regulation of protein secretion	GO:0050708	82	0.054
response to decreased oxygen levels	GO:0036293	59	0.054
regulation of tyrosine phosphorylation of stat1 protein	GO:0042510	2	0.054
cellular response to peptide	GO:1901653	92	0.054
cell type specific apoptotic process	GO:0097285	268	0.054
positive regulation of production of molecular mediator of immune response	GO:0002702	45	0.054
regulation of lymphocyte apoptotic process	GO:0070228	41	0.053
adhesion of symbiont to host	GO:0044406	8	0.053
organic hydroxy compound metabolic process	GO:1901615	203	0.053
protein processing	GO:0016485	163	0.053
chromatin organization	GO:0006325	206	0.053	Mouse
positive regulation of nervous system development	GO:0051962	221	0.053
intrinsic apoptotic signaling pathway	GO:0097193	132	0.053
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.052
positive regulation of endopeptidase activity	GO:0010950	43	0.052
stem cell development	GO:0048864	219	0.051
nucleoside triphosphate catabolic process	GO:0009143	205	0.051
glial cell differentiation	GO:0010001	131	0.051
positive regulation of t cell differentiation	GO:0045582	52	0.051
regulation of myd88 dependent toll like receptor signaling pathway	GO:0034124	2	0.051
positive regulation of defense response to bacterium	GO:1900426	1	0.051
positive regulation of notch signaling pathway	GO:0045747	18	0.051
t cell lineage commitment	GO:0002360	13	0.051	Mouse
cell fate commitment	GO:0045165	210	0.051	Mouse
negative regulation of nik nf kappab signaling	GO:1901223	2	0.051
myeloid leukocyte migration	GO:0097529	57	0.051
regulation of production of molecular mediator of immune response	GO:0002700	65	0.050
intracellular protein transport	GO:0006886	204	0.050
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	1	0.050
regulation of intracellular protein transport	GO:0033157	82	0.049
ribonucleotide catabolic process	GO:0009261	208	0.049
response to muramyl dipeptide	GO:0032495	9	0.049
positive regulation of t cell proliferation	GO:0042102	52	0.049
muscle tissue development	GO:0060537	308	0.049
interleukin 4 production	GO:0032633	24	0.049
negative regulation of cell motility	GO:2000146	61	0.049
granulocyte chemotaxis	GO:0071621	39	0.049
somatic cell dna recombination	GO:0016444	51	0.049
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.048
purine nucleotide metabolic process	GO:0006163	302	0.048
rhythmic process	GO:0048511	174	0.048
positive regulation of antimicrobial humoral response	GO:0002760	2	0.048
citrate metabolic process	GO:0006101	3	0.048
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.047
chromatin modification	GO:0016568	187	0.047	Mouse
response to copper ion	GO:0046688	3	0.047
negative regulation of intracellular protein transport	GO:0090317	27	0.047
regulation of t helper 1 type immune response	GO:0002825	17	0.047
interleukin 11 mediated signaling pathway	GO:0038154	2	0.046
cellular response to growth factor stimulus	GO:0071363	197	0.046
maintenance of location	GO:0051235	89	0.046
response to oxidative stress	GO:0006979	123	0.046
negative regulation of t cell differentiation	GO:0045581	23	0.046
sequestering of metal ion	GO:0051238	19	0.046
interleukin 12 production	GO:0032615	32	0.046
immunoglobulin production	GO:0002377	73	0.046
positive t cell selection	GO:0043368	23	0.046	Mouse
protein targeting	GO:0006605	143	0.045
regulation of natural killer cell differentiation	GO:0032823	11	0.045
regulation of mapk cascade	GO:0043408	248	0.045
reactive nitrogen species metabolic process	GO:2001057	0	0.045
regulation of cytokine production involved in immune response	GO:0002718	26	0.045
cell chemotaxis	GO:0060326	81	0.045
regulation of organelle organization	GO:0033043	289	0.045
polysaccharide metabolic process	GO:0005976	39	0.045
cellular response to external stimulus	GO:0071496	88	0.045	Human
generation of precursor metabolites and energy	GO:0006091	103	0.045
positive regulation of nucleotide metabolic process	GO:0045981	114	0.044
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.044
cellular response to steroid hormone stimulus	GO:0071383	33	0.044
negative regulation of leukocyte proliferation	GO:0070664	46	0.044
neuron apoptotic process	GO:0051402	142	0.044
regulation of cell activation	GO:0050865	289	0.044
cation transport	GO:0006812	399	0.044
dendrite development	GO:0016358	115	0.044
regulation of protein localization to nucleus	GO:1900180	60	0.044
regulation of mast cell differentiation	GO:0060375	3	0.044
modification of morphology or physiology of other organism involved in symbiotic interaction	GO:0051817	16	0.043
release of sequestered calcium ion into cytosol	GO:0051209	42	0.043
positive regulation of type i interferon mediated signaling pathway	GO:0060340	4	0.043	Mouse
jak stat cascade involved in growth hormone signaling pathway	GO:0060397	4	0.043
mammary gland morphogenesis	GO:0060443	54	0.043
neuron death	GO:0070997	154	0.042
negative regulation of lymphocyte proliferation	GO:0050672	45	0.042
regulation of defense response to fungus	GO:1900150	1	0.042
establishment of protein localization to organelle	GO:0072594	118	0.042
cd4 positive alpha beta t cell lineage commitment	GO:0043373	6	0.042	Mouse
t cell selection	GO:0045058	34	0.042	Mouse
cellular homeostasis	GO:0019725	240	0.041
positive regulation of interleukin 1 beta production	GO:0032731	16	0.041
tolerance induction dependent upon immune response	GO:0002461	1	0.041
regulation of muscle tissue development	GO:1901861	97	0.041
response to interleukin 1	GO:0070555	11	0.041

Irf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.069
nervous system disease	DOID:863	0.069
central nervous system disease	DOID:331	0.051
primary immunodeficiency disease	DOID:612	0.049
severe combined immunodeficiency	DOID:627	0.049
combined t cell and b cell immunodeficiency	DOID:628	0.049
immune system disease	DOID:2914	0.049

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