IMP: Integrative Multi-species Prediction

Mus musculus

31 known processes

Itga5

integrin alpha 5 (fibronectin receptor alpha)

(Aliases: Cd49e,VLA5,Fnra)

Entrez: 16402
Ensembl: ENSMUSG00000000555
UniProtKB: Q80YP5
UniProtKB: P11688

Process Predictions
Disease Predictions

Itga5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell matrix adhesion	GO:0007160	68	0.904	Mouse
cell junction organization	GO:0034330	77	0.892
single organismal cell cell adhesion	GO:0016337	131	0.870
cell adhesion	GO:0007155	329	0.812
regulation of cell adhesion	GO:0030155	154	0.794	Mouse
response to growth factor	GO:0070848	198	0.762	Mouse
actin filament organization	GO:0007015	113	0.758	Fly
regulation of cell migration	GO:0030334	219	0.749	Mouse
ras protein signal transduction	GO:0007265	77	0.704	Mouse
cell substrate adhesion	GO:0031589	130	0.696	Human Mouse
regionalization	GO:0003002	337	0.672	Zebrafish
mesenchyme development	GO:0060485	152	0.651
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.614
extracellular matrix organization	GO:0030198	147	0.597	Zebrafish Mouse
blood vessel morphogenesis	GO:0048514	285	0.565	Zebrafish Mouse
axonogenesis	GO:0007409	274	0.559	Fly
stem cell differentiation	GO:0048863	268	0.551
stem cell development	GO:0048864	219	0.549
myeloid cell differentiation	GO:0030099	233	0.544	Mouse
synaptic transmission	GO:0007268	329	0.513
regulation of cell motility	GO:2000145	236	0.484	Mouse
extracellular structure organization	GO:0043062	148	0.456	Zebrafish Mouse
negative regulation of cell migration	GO:0030336	59	0.443
striated muscle tissue development	GO:0014706	293	0.429
positive regulation of cell motility	GO:2000147	116	0.427	Mouse
cardiac muscle tissue development	GO:0048738	130	0.426
positive regulation of cell migration	GO:0030335	109	0.420	Mouse
organelle assembly	GO:0070925	177	0.418	Fly
skeletal system development	GO:0001501	356	0.416	Zebrafish
neuron projection guidance	GO:0097485	141	0.416	Fly
axon guidance	GO:0007411	141	0.413	Fly
rho protein signal transduction	GO:0007266	32	0.412	Mouse
ameboidal type cell migration	GO:0001667	128	0.409	Zebrafish Fly
myeloid leukocyte differentiation	GO:0002573	119	0.400	Mouse
mesenchymal cell differentiation	GO:0048762	107	0.399
positive regulation of protein modification process	GO:0031401	299	0.387	Human
skeletal system morphogenesis	GO:0048705	203	0.378
chemotaxis	GO:0006935	247	0.366	Mouse Fly
circulatory system process	GO:0003013	197	0.340
embryonic placenta development	GO:0001892	98	0.339	Mouse
mesenchymal cell development	GO:0014031	93	0.339
actin cytoskeleton organization	GO:0030036	220	0.330	Fly
urogenital system development	GO:0001655	261	0.326	Mouse
wound healing	GO:0042060	157	0.325	Human
lymphocyte differentiation	GO:0030098	242	0.314
epithelial tube morphogenesis	GO:0060562	303	0.312
leukocyte migration	GO:0050900	124	0.310	Mouse
cellular amine metabolic process	GO:0044106	44	0.307
cell migration involved in endocardial cushion formation	GO:0003273	3	0.307
regulation of apoptotic signaling pathway	GO:2001233	197	0.305
muscle cell development	GO:0055001	133	0.300	Fly
ribonucleotide metabolic process	GO:0009259	291	0.298
organonitrogen compound biosynthetic process	GO:1901566	192	0.297
cellular response to growth factor stimulus	GO:0071363	197	0.289	Mouse
purine containing compound metabolic process	GO:0072521	311	0.281
nucleoside phosphate metabolic process	GO:0006753	338	0.279
single organism cell adhesion	GO:0098602	156	0.272
substrate dependent cell migration	GO:0006929	18	0.270	Mouse
regulation of neuron projection development	GO:0010975	169	0.270
apoptotic signaling pathway	GO:0097190	306	0.266	Mouse
muscle cell differentiation	GO:0042692	261	0.260	Mouse Fly
epidermis development	GO:0008544	187	0.256
negative regulation of cell motility	GO:2000146	61	0.255
actin filament bundle assembly	GO:0051017	40	0.254	Fly
positive regulation of cell death	GO:0010942	224	0.254
immune response activating signal transduction	GO:0002757	116	0.253
immune response regulating signaling pathway	GO:0002764	125	0.252
sphingolipid metabolic process	GO:0006665	45	0.246
cellular component assembly involved in morphogenesis	GO:0010927	139	0.242	Fly
angiogenesis	GO:0001525	201	0.234	Zebrafish
regulation of actin cytoskeleton organization	GO:0032956	84	0.227	Fly
sarcomere organization	GO:0045214	24	0.224
muscle tissue development	GO:0060537	308	0.223	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.218	Mouse
sensory perception	GO:0007600	245	0.217	Fly
platelet activation	GO:0030168	40	0.216
epithelium migration	GO:0090132	63	0.215	Zebrafish Fly
blood vessel endothelial cell migration	GO:0043534	23	0.213	Zebrafish
nucleobase containing small molecule metabolic process	GO:0055086	352	0.208
organonitrogen compound catabolic process	GO:1901565	264	0.206
epithelial cell migration	GO:0010631	63	0.206	Zebrafish Fly
leukocyte differentiation	GO:0002521	342	0.204	Mouse
nucleotide metabolic process	GO:0009117	332	0.201
epithelial to mesenchymal transition	GO:0001837	47	0.200
positive regulation of mapk cascade	GO:0043410	170	0.199
skeletal muscle organ development	GO:0060538	163	0.197	Fly
epithelial cell development	GO:0002064	159	0.193	Zebrafish Fly
striated muscle cell development	GO:0055002	125	0.191	Fly
cardiac chamber morphogenesis	GO:0003206	93	0.190
muscle contraction	GO:0006936	101	0.189	Worm
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation	GO:2000721	2	0.186	Mouse
regulation of transferase activity	GO:0051338	263	0.186
keratinocyte migration	GO:0051546	3	0.185
protein catabolic process	GO:0030163	221	0.184	Worm
heart morphogenesis	GO:0003007	178	0.184
peptidyl amino acid modification	GO:0018193	336	0.182	Human
cardiocyte differentiation	GO:0035051	87	0.180
cell junction assembly	GO:0034329	52	0.179
purine ribonucleotide metabolic process	GO:0009150	290	0.178
amine metabolic process	GO:0009308	45	0.178
regulation of cytoskeleton organization	GO:0051493	122	0.178	Fly
regulation of organelle organization	GO:0033043	289	0.177	Fly
branching morphogenesis of an epithelial tube	GO:0048754	159	0.174
blood circulation	GO:0008015	195	0.174
regulation of cellular amino acid metabolic process	GO:0006521	5	0.171
regulation of cellular component size	GO:0032535	121	0.169
membrane organization	GO:0061024	245	0.168	Worm
skin development	GO:0043588	220	0.166
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.165
embryonic organ morphogenesis	GO:0048562	276	0.165	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.163
actomyosin structure organization	GO:0031032	56	0.162	Fly
small gtpase mediated signal transduction	GO:0007264	97	0.162	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.162
response to fibroblast growth factor	GO:0071774	47	0.158
cell chemotaxis	GO:0060326	81	0.157	Mouse
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.157
erk1 and erk2 cascade	GO:0070371	77	0.156	Mouse
t cell activation	GO:0042110	289	0.156	Mouse
purine nucleotide metabolic process	GO:0006163	302	0.155
regulation of ras protein signal transduction	GO:0046578	114	0.152	Mouse
regulation of fat cell differentiation	GO:0045598	81	0.152
g protein coupled receptor signaling pathway	GO:0007186	243	0.151
tissue migration	GO:0090130	68	0.151	Zebrafish Fly
extrinsic apoptotic signaling pathway	GO:0097191	126	0.149	Mouse
forebrain development	GO:0030900	302	0.147
gland development	GO:0048732	330	0.147	Zebrafish Fly
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.146
regulation of actin filament based process	GO:0032970	99	0.142	Fly
nucleoside triphosphate metabolic process	GO:0009141	230	0.141
regulation of cell substrate adhesion	GO:0010810	73	0.137
regulation of cellular ketone metabolic process	GO:0010565	66	0.137
cell cell junction organization	GO:0045216	72	0.136
posttranscriptional regulation of gene expression	GO:0010608	155	0.134
purine nucleoside metabolic process	GO:0042278	241	0.133
innate immune response	GO:0045087	157	0.132
negative regulation of ras protein signal transduction	GO:0046580	18	0.130	Mouse
heart trabecula morphogenesis	GO:0061384	26	0.129
regulation of secretion by cell	GO:1903530	249	0.128
regulation of tube size	GO:0035150	57	0.126
odontogenesis of dentin containing tooth	GO:0042475	66	0.125	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.125
regulation of blood pressure	GO:0008217	93	0.124
positive regulation of organelle organization	GO:0010638	128	0.124
cardiac chamber development	GO:0003205	108	0.124
muscle system process	GO:0003012	141	0.123	Worm
limb development	GO:0060173	166	0.123
t cell differentiation	GO:0030217	174	0.121
maintenance of location	GO:0051235	89	0.119	Fly
leukocyte proliferation	GO:0070661	172	0.117	Mouse
myofibril assembly	GO:0030239	34	0.117	Fly
regulation of protein autophosphorylation	GO:0031952	8	0.116
regulation of cytokine production	GO:0001817	266	0.115
regulation of angiogenesis	GO:0045765	81	0.115
cartilage development	GO:0051216	140	0.115
lymphocyte proliferation	GO:0046651	164	0.115	Mouse
placenta development	GO:0001890	140	0.114	Mouse
cardiac septum development	GO:0003279	59	0.111
positive regulation of defense response	GO:0031349	124	0.109
nephron development	GO:0072006	109	0.109
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.108
leukocyte mediated immunity	GO:0002443	174	0.107
cellular extravasation	GO:0045123	17	0.106	Mouse
regulation of epithelial to mesenchymal transition	GO:0010717	22	0.104
positive regulation of protein phosphorylation	GO:0001934	242	0.104	Human
neurotransmitter transport	GO:0006836	76	0.102
cell type specific apoptotic process	GO:0097285	268	0.102
positive regulation of cell development	GO:0010720	237	0.101
dna metabolic process	GO:0006259	303	0.100
regulation of cartilage development	GO:0061035	44	0.100
regulation of nucleotide metabolic process	GO:0006140	169	0.099
organophosphate biosynthetic process	GO:0090407	122	0.099
cell activation involved in immune response	GO:0002263	126	0.099
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.097	Mouse
positive regulation of cell adhesion	GO:0045785	80	0.097	Mouse
hemostasis	GO:0007599	78	0.095
cytokine production	GO:0001816	319	0.094
regulation of cell activation	GO:0050865	289	0.094	Mouse
multicellular organismal homeostasis	GO:0048871	164	0.093	Mouse Fly
negative regulation of protein phosphorylation	GO:0001933	126	0.093
response to transforming growth factor beta	GO:0071559	88	0.092	Mouse
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.092
venous blood vessel development	GO:0060841	13	0.092
nucleoside catabolic process	GO:0009164	206	0.091
cellular response to lipopolysaccharide	GO:0071222	77	0.091
regulation of vasculature development	GO:1901342	88	0.090
regulation of ion transport	GO:0043269	215	0.090
regulation of anatomical structure size	GO:0090066	178	0.089
positive regulation of transferase activity	GO:0051347	167	0.088
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.087	Mouse
myeloid leukocyte activation	GO:0002274	83	0.087
positive regulation of neuron projection development	GO:0010976	79	0.087
fibrinolysis	GO:0042730	3	0.087
epithelial cell proliferation	GO:0050673	174	0.086
cognition	GO:0050890	149	0.086
mesoderm morphogenesis	GO:0048332	64	0.085
cell migration involved in sprouting angiogenesis	GO:0002042	9	0.084	Zebrafish
positive regulation of cellular catabolic process	GO:0031331	148	0.083
embryonic heart tube development	GO:0035050	65	0.082
vascular process in circulatory system	GO:0003018	62	0.082
formation of radial glial scaffolds	GO:0021943	4	0.082
cellular response to biotic stimulus	GO:0071216	92	0.081
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.081
definitive hemopoiesis	GO:0060216	20	0.081
purine containing compound catabolic process	GO:0072523	213	0.080
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.080
negative regulation of interleukin 10 secretion	GO:2001180	2	0.080
heart trabecula formation	GO:0060347	14	0.079
endothelial cell migration	GO:0043542	44	0.079	Zebrafish
regulation of histone modification	GO:0031056	56	0.079
bone development	GO:0060348	120	0.078
male gamete generation	GO:0048232	285	0.078
regulation of epithelial cell migration	GO:0010632	35	0.078
transmembrane transport	GO:0055085	412	0.078
limb morphogenesis	GO:0035108	149	0.078
divalent inorganic cation homeostasis	GO:0072507	138	0.078
response to radiation	GO:0009314	165	0.078
germ cell development	GO:0007281	185	0.078	Fly
macromolecule deacylation	GO:0098732	37	0.077
aminoglycan metabolic process	GO:0006022	34	0.077
positive regulation of hydrolase activity	GO:0051345	148	0.077
glycosyl compound metabolic process	GO:1901657	246	0.076
appendage development	GO:0048736	166	0.076	Fly
gtp catabolic process	GO:0006184	143	0.076
regulation of tight junction assembly	GO:2000810	2	0.076
somitogenesis	GO:0001756	69	0.076	Zebrafish
mitotic cell cycle process	GO:1903047	159	0.075
cellular homeostasis	GO:0019725	240	0.075
positive regulation of leukocyte differentiation	GO:1902107	86	0.075	Mouse
protein autophosphorylation	GO:0046777	61	0.075
organic acid transport	GO:0015849	101	0.075
heterocycle catabolic process	GO:0046700	280	0.075
negative regulation of cell morphogenesis involved in differentiation	GO:0010771	48	0.074
positive regulation of apoptotic process	GO:0043065	217	0.074
response to oxygen levels	GO:0070482	62	0.074
development of primary female sexual characteristics	GO:0046545	73	0.074
carbohydrate derivative catabolic process	GO:1901136	231	0.073
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.073
ribose phosphate metabolic process	GO:0019693	291	0.073
positive regulation of lymphocyte activation	GO:0051251	140	0.073	Mouse
spermatogenesis	GO:0007283	284	0.073
purine ribonucleotide catabolic process	GO:0009154	208	0.073
cellular ion homeostasis	GO:0006873	165	0.072
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.072
regulation of axon extension	GO:0030516	43	0.072
salivary gland morphogenesis	GO:0007435	33	0.072	Fly
positive regulation of nervous system development	GO:0051962	221	0.072
regulation of innate immune response	GO:0045088	91	0.071
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.071
chromatin organization	GO:0006325	206	0.071
negative regulation of pathway restricted smad protein phosphorylation	GO:0060394	1	0.070
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.070
mucopolysaccharide metabolic process	GO:1903510	25	0.069
regulation of cell cycle	GO:0051726	281	0.069
rhythmic process	GO:0048511	174	0.069
nucleoside triphosphate catabolic process	GO:0009143	205	0.069
signal transduction in absence of ligand	GO:0038034	55	0.069	Mouse
stem cell maintenance	GO:0019827	130	0.068
morphogenesis of a branching structure	GO:0001763	203	0.068
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.068
regulation of hydrolase activity	GO:0051336	246	0.068
positive regulation of programmed cell death	GO:0043068	218	0.068
negative regulation of protein metabolic process	GO:0051248	282	0.068
connective tissue development	GO:0061448	179	0.068
heparin biosynthetic process	GO:0030210	2	0.068
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.067
nucleotide catabolic process	GO:0009166	217	0.067
developmental maturation	GO:0021700	193	0.067
chromatin modification	GO:0016568	187	0.066
aromatic compound catabolic process	GO:0019439	286	0.066
positive regulation of innate immune response	GO:0045089	80	0.066
organ growth	GO:0035265	117	0.066
anatomical structure homeostasis	GO:0060249	145	0.065	Mouse Fly
regulation of protein serine threonine kinase activity	GO:0071900	157	0.065
regulation of protein kinase activity	GO:0045859	232	0.064
regulation of cell projection organization	GO:0031344	206	0.064
nucleoside metabolic process	GO:0009116	246	0.064
positive regulation of dna biosynthetic process	GO:2000573	4	0.064
nephron epithelium morphogenesis	GO:0072088	68	0.064
guanosine containing compound catabolic process	GO:1901069	144	0.064
regulation of lymphocyte activation	GO:0051249	240	0.063	Mouse
sensory organ morphogenesis	GO:0090596	242	0.063	Zebrafish Mouse
t cell migration	GO:0072678	19	0.062	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.062	Mouse
cellular calcium ion homeostasis	GO:0006874	119	0.061
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.061
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.061	Mouse
cell aging	GO:0007569	35	0.061
substrate dependent cell migration cell extension	GO:0006930	4	0.061
cellular lipid metabolic process	GO:0044255	323	0.061
developmental cell growth	GO:0048588	84	0.060
regulation of neurotransmitter levels	GO:0001505	87	0.060
liposaccharide metabolic process	GO:1903509	27	0.060
macromolecule catabolic process	GO:0009057	281	0.060	Worm
appendage morphogenesis	GO:0035107	149	0.060	Fly
male gonad development	GO:0008584	88	0.060
lymphocyte migration	GO:0072676	26	0.060	Mouse
signal transduction by p53 class mediator	GO:0072331	51	0.059
purine ribonucleoside metabolic process	GO:0046128	241	0.059
regulation of receptor activity	GO:0010469	41	0.059
negative regulation of endothelial cell migration	GO:0010596	4	0.059
regulation of rho gtpase activity	GO:0032319	58	0.059
negative regulation of rho protein signal transduction	GO:0035024	7	0.058	Mouse
trabecula morphogenesis	GO:0061383	40	0.058
mapk cascade	GO:0000165	281	0.058	Mouse
purine ribonucleoside catabolic process	GO:0046130	205	0.057
odontogenesis	GO:0042476	78	0.057	Mouse
mesodermal cell migration	GO:0008078	4	0.057
ribonucleotide catabolic process	GO:0009261	208	0.057
covalent chromatin modification	GO:0016569	163	0.057
positive regulation of cell activation	GO:0050867	158	0.057	Mouse
cellular response to molecule of bacterial origin	GO:0071219	83	0.057
digestive tract development	GO:0048565	190	0.056	Human
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.056
mesoderm development	GO:0007498	100	0.056
regulation of mapk cascade	GO:0043408	248	0.055
negative regulation of cell adhesion	GO:0007162	45	0.055
positive regulation of cell growth	GO:0030307	33	0.055
adherens junction assembly	GO:0034333	22	0.055
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.055
respiratory system development	GO:0060541	190	0.055	Fly
positive regulation of axon extension	GO:0045773	20	0.054
regulation of inflammatory response	GO:0050727	147	0.054
regulation of purine nucleotide metabolic process	GO:1900542	169	0.054
regulation of gtp catabolic process	GO:0033124	113	0.054
detection of external stimulus	GO:0009581	61	0.054
regulation of neurotransmitter transport	GO:0051588	35	0.054
trophoblast giant cell differentiation	GO:0060707	15	0.054
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.054
immune effector process	GO:0002252	321	0.053	Mouse
leukocyte activation involved in immune response	GO:0002366	126	0.053
interleukin 13 secretion	GO:0072611	2	0.053
cell substrate junction assembly	GO:0007044	24	0.053
nucleoside phosphate catabolic process	GO:1901292	222	0.053
regulation of cellular catabolic process	GO:0031329	242	0.053
striated muscle contraction	GO:0006941	45	0.053	Worm
chondrocyte differentiation	GO:0002062	72	0.052
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.052	Mouse
vasoconstriction	GO:0042310	27	0.052
cellular nitrogen compound catabolic process	GO:0044270	280	0.052
anion transport	GO:0006820	177	0.052
activation of mapk activity	GO:0000187	59	0.052
positive regulation of nucleotide metabolic process	GO:0045981	114	0.051
regulation of ossification	GO:0030278	112	0.051
positive regulation of neuron projection regeneration	GO:0070572	2	0.050
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.050
activation of immune response	GO:0002253	138	0.050
sprouting angiogenesis	GO:0002040	26	0.050	Zebrafish
lung development	GO:0030324	164	0.050
organic cyclic compound catabolic process	GO:1901361	295	0.050
divalent metal ion transport	GO:0070838	172	0.050
regulation of secretion	GO:0051046	274	0.050
central nervous system vasculogenesis	GO:0022009	3	0.050
regulation of defense response	GO:0031347	233	0.050
protein localization to cell junction	GO:1902414	3	0.050
glycoprotein biosynthetic process	GO:0009101	89	0.049
rac protein signal transduction	GO:0016601	13	0.049
segmentation	GO:0035282	93	0.049	Zebrafish
organelle localization	GO:0051640	179	0.048
myeloid cell homeostasis	GO:0002262	114	0.048
branching involved in salivary gland morphogenesis	GO:0060445	26	0.048
nitrogen compound transport	GO:0071705	271	0.048
fat cell differentiation	GO:0045444	160	0.048	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.048
positive regulation of cellular component biogenesis	GO:0044089	94	0.048
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.048
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.047
regulation of ras gtpase activity	GO:0032318	88	0.047
polysaccharide metabolic process	GO:0005976	39	0.047
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.047
lymphocyte mediated immunity	GO:0002449	139	0.047
cellular chemical homeostasis	GO:0055082	215	0.047
ventricular septum development	GO:0003281	42	0.047
histone modification	GO:0016570	159	0.047
regulation of stem cell differentiation	GO:2000736	50	0.047
ovulation cycle	GO:0042698	59	0.047
positive regulation of t helper 1 cell differentiation	GO:0045627	4	0.046
female gamete generation	GO:0007292	74	0.046	Fly
regulation of vesicle mediated transport	GO:0060627	139	0.046	Mouse Worm
endochondral bone morphogenesis	GO:0060350	50	0.046
response to tumor necrosis factor	GO:0034612	26	0.046
aminoglycan biosynthetic process	GO:0006023	15	0.045
regulation of response to wounding	GO:1903034	189	0.045
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.045
negative regulation of cellular protein metabolic process	GO:0032269	247	0.045
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.045	Mouse
cardiac ventricle development	GO:0003231	83	0.045
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.045
regulation of homeostatic process	GO:0032844	182	0.045	Mouse
inflammatory response	GO:0006954	244	0.045	Mouse
defense response to bacterium	GO:0042742	119	0.045
granulocyte migration	GO:0097530	43	0.045	Mouse
t cell proliferation	GO:0042098	120	0.045	Mouse
production of molecular mediator of immune response	GO:0002440	103	0.045
female gonad development	GO:0008585	71	0.044
cellular response to follicle stimulating hormone stimulus	GO:0071372	1	0.044
regulation of leukocyte differentiation	GO:1902105	159	0.044	Mouse
focal adhesion assembly	GO:0048041	19	0.044
digestive system development	GO:0055123	200	0.044	Human
cell recognition	GO:0008037	83	0.044	Fly
calcium ion homeostasis	GO:0055074	127	0.044
regulation of systemic arterial blood pressure	GO:0003073	61	0.043
regulation of bmp signaling pathway	GO:0030510	60	0.043
response to decreased oxygen levels	GO:0036293	59	0.043
negative regulation of synaptic vesicle transport	GO:1902804	3	0.043
establishment of endothelial blood brain barrier	GO:0014045	3	0.043
neurotransmitter secretion	GO:0007269	62	0.043
cell growth	GO:0016049	130	0.042
response to hypoxia	GO:0001666	58	0.042
glycosyl compound catabolic process	GO:1901658	206	0.042
diencephalon development	GO:0021536	63	0.042
organic hydroxy compound metabolic process	GO:1901615	203	0.042
synapse organization	GO:0050808	125	0.042
peptidyl tyrosine phosphorylation	GO:0018108	143	0.042	Human
ossification	GO:0001503	216	0.042
learning	GO:0007612	98	0.041
interleukin 5 secretion	GO:0072603	2	0.041
positive regulation of leukocyte proliferation	GO:0070665	73	0.041	Mouse
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902042	11	0.041
metal ion homeostasis	GO:0055065	189	0.041
response to light stimulus	GO:0009416	135	0.041
labyrinthine layer development	GO:0060711	49	0.041	Mouse
camera type eye development	GO:0043010	266	0.041	Zebrafish
regulation of system process	GO:0044057	200	0.041
neuroepithelial cell differentiation	GO:0060563	37	0.041
histone deacetylation	GO:0016575	26	0.040
response to interleukin 1	GO:0070555	11	0.040
tissue remodeling	GO:0048771	102	0.040	Mouse
nuclear division	GO:0000280	158	0.040
negative regulation of cellular component organization	GO:0051129	194	0.040
response to inorganic substance	GO:0010035	96	0.040
endocrine system development	GO:0035270	98	0.040	Zebrafish
positive regulation of cytokine production	GO:0001819	174	0.039
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.039
purine nucleoside catabolic process	GO:0006152	205	0.039
leukocyte apoptotic process	GO:0071887	71	0.039
positive regulation of cell projection organization	GO:0031346	95	0.039
salivary gland development	GO:0007431	37	0.039	Fly
actin cytoskeleton reorganization	GO:0031532	21	0.039
cell maturation	GO:0048469	127	0.039
female sex differentiation	GO:0046660	84	0.039
lipid biosynthetic process	GO:0008610	179	0.039
organelle fission	GO:0048285	170	0.038
cellular metal ion homeostasis	GO:0006875	151	0.038
negative regulation of cell development	GO:0010721	169	0.038
regulation of cellular amine metabolic process	GO:0033238	20	0.038
embryonic limb morphogenesis	GO:0030326	126	0.038
multicellular organismal macromolecule metabolic process	GO:0044259	19	0.038
cellular ketone metabolic process	GO:0042180	84	0.038
cation transport	GO:0006812	399	0.038
regulation of osteoblast differentiation	GO:0045667	67	0.038
cellular response to amino acid stimulus	GO:0071230	29	0.038
regulation of purine nucleotide catabolic process	GO:0033121	122	0.038
cellular response to lipid	GO:0071396	145	0.037
collagen fibril organization	GO:0030199	32	0.037
negative regulation of cytokine production	GO:0001818	84	0.037
synapse assembly	GO:0007416	56	0.037
cell differentiation involved in embryonic placenta development	GO:0060706	26	0.037
g1 s transition of mitotic cell cycle	GO:0000082	57	0.037
cardiac muscle cell differentiation	GO:0055007	69	0.037
osteoclast differentiation	GO:0030316	62	0.036	Mouse
homeostasis of number of cells	GO:0048872	210	0.036
protein maturation	GO:0051604	176	0.036
protein localization to membrane	GO:0072657	108	0.036
response to insulin	GO:0032868	100	0.036
spermatid differentiation	GO:0048515	115	0.036
divalent inorganic cation transport	GO:0072511	178	0.036
ribonucleoside metabolic process	GO:0009119	245	0.036
protein processing	GO:0016485	163	0.036
response to organonitrogen compound	GO:0010243	246	0.035
dendritic spine maintenance	GO:0097062	4	0.035	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.035
positive regulation of gtp catabolic process	GO:0033126	85	0.035
negative regulation of cell substrate adhesion	GO:0010812	16	0.035
intrinsic apoptotic signaling pathway	GO:0097193	132	0.035
erythrocyte differentiation	GO:0030218	88	0.035
carboxylic acid transport	GO:0046942	100	0.035
acetate ester transport	GO:1901374	2	0.035
ceramide metabolic process	GO:0006672	31	0.035
fertilization	GO:0009566	127	0.034
antigen receptor mediated signaling pathway	GO:0050851	64	0.034
secretory granule organization	GO:0033363	20	0.034
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.034

Itga5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.378
musculoskeletal system disease	DOID:17	0.378
connective tissue disease	DOID:65	0.271
muscular disease	DOID:0080000	0.165
muscle tissue disease	DOID:66	0.106
bone disease	DOID:0080001	0.065
disease of cellular proliferation	DOID:14566	0.052
heart disease	DOID:114	0.045
cardiovascular system disease	DOID:1287	0.045
myopathy	DOID:423	0.037
cancer	DOID:162	0.036
organ system cancer	DOID:0050686	0.036

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