IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Kdelr3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

(Aliases: AI173274)

Entrez: 105785
Ensembl: ENSMUSG00000010830
UniProtKB: Q8R1L4

Process Predictions
Disease Predictions

Kdelr3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
extracellular matrix organization	GO:0030198	147	0.739
protein hydroxylation	GO:0018126	4	0.619
extracellular structure organization	GO:0043062	148	0.513
collagen fibril organization	GO:0030199	32	0.463
wound healing	GO:0042060	157	0.153
skeletal system development	GO:0001501	356	0.152
connective tissue development	GO:0061448	179	0.113
positive regulation of cell death	GO:0010942	224	0.101
cellular response to acid chemical	GO:0071229	68	0.085
cell substrate adhesion	GO:0031589	130	0.083
oxidation reduction process	GO:0055114	342	0.081
fibrinolysis	GO:0042730	3	0.077
membrane raft assembly	GO:0001765	3	0.077
extrinsic apoptotic signaling pathway	GO:0097191	126	0.074
regulation of chondrocyte differentiation	GO:0032330	33	0.070
glycoprotein metabolic process	GO:0009100	116	0.067
cellular amino acid metabolic process	GO:0006520	103	0.065
ossification	GO:0001503	216	0.064
regulation of apoptotic signaling pathway	GO:2001233	197	0.064
cartilage development	GO:0051216	140	0.060
chromatin organization	GO:0006325	206	0.058
regulation of vesicle mediated transport	GO:0060627	139	0.055
monocarboxylic acid metabolic process	GO:0032787	191	0.053
peptidyl proline hydroxylation	GO:0019511	3	0.052
multi multicellular organism process	GO:0044706	109	0.051
angiogenesis	GO:0001525	201	0.050
signal transduction in absence of ligand	GO:0038034	55	0.049
immune effector process	GO:0002252	321	0.049
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.048
regulation of organelle organization	GO:0033043	289	0.046
endochondral bone morphogenesis	GO:0060350	50	0.046
collagen biosynthetic process	GO:0032964	7	0.046
anion transport	GO:0006820	177	0.046
ras protein signal transduction	GO:0007265	77	0.044
peptidyl amino acid modification	GO:0018193	336	0.044
regulation of integrin mediated signaling pathway	GO:2001044	8	0.044
head morphogenesis	GO:0060323	34	0.043
cellular modified amino acid metabolic process	GO:0006575	63	0.042
small gtpase mediated signal transduction	GO:0007264	97	0.042
fat cell differentiation	GO:0045444	160	0.040
endomembrane system organization	GO:0010256	147	0.040
bone development	GO:0060348	120	0.039
response to organic cyclic compound	GO:0014070	198	0.039
regulation of cell substrate adhesion	GO:0010810	73	0.039
cellular ketone metabolic process	GO:0042180	84	0.039
apoptotic signaling pathway	GO:0097190	306	0.038
response to acid chemical	GO:0001101	111	0.038
synaptic transmission	GO:0007268	329	0.037
epithelial to mesenchymal transition	GO:0001837	47	0.037
spermatogenesis	GO:0007283	284	0.037
cation transport	GO:0006812	399	0.037
regulation of response to wounding	GO:1903034	189	0.037
regulation of cell motility	GO:2000145	236	0.036
regulation of cell adhesion	GO:0030155	154	0.036
protein maturation	GO:0051604	176	0.034
synaptic transmission cholinergic	GO:0007271	7	0.034
positive regulation of cell substrate adhesion	GO:0010811	47	0.034
cell matrix adhesion	GO:0007160	68	0.034
peptidyl proline modification	GO:0018208	6	0.033
cerebral cortex development	GO:0021987	86	0.033
regulation of body fluid levels	GO:0050878	162	0.032
lung development	GO:0030324	164	0.032
organic acid transport	GO:0015849	101	0.032
male gamete generation	GO:0048232	285	0.032
cytoplasmic transport	GO:0016482	234	0.031
cell adhesion	GO:0007155	329	0.030
digestive tract development	GO:0048565	190	0.030
ameboidal type cell migration	GO:0001667	128	0.029
chondrocyte differentiation	GO:0002062	72	0.028
regulation of bone mineralization	GO:0030500	31	0.028
localization within membrane	GO:0051668	4	0.027
glycosyl compound metabolic process	GO:1901657	246	0.027
multicellular organismal macromolecule metabolic process	GO:0044259	19	0.027
response to hypoxia	GO:0001666	58	0.026
positive regulation of interleukin 6 secretion	GO:2000778	1	0.026
positive regulation of programmed cell death	GO:0043068	218	0.026
respiratory tube development	GO:0030323	167	0.026
tissue homeostasis	GO:0001894	115	0.026
fibril organization	GO:0097435	2	0.026
sphingolipid biosynthetic process	GO:0030148	26	0.026
regulation of immunological synapse formation	GO:2000520	2	0.025
regulation of protein kinase activity	GO:0045859	232	0.025
negative regulation of cell proliferation	GO:0008285	296	0.025
defense response to other organism	GO:0098542	197	0.024
chondrocyte development	GO:0002063	24	0.024
positive regulation of apoptotic process	GO:0043065	217	0.024
regulation of cell cycle	GO:0051726	281	0.024
negative regulation of gastrulation	GO:2000542	3	0.024
stem cell development	GO:0048864	219	0.024
peripheral nervous system axon regeneration	GO:0014012	2	0.023
carboxylic acid transport	GO:0046942	100	0.023
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.023
replacement ossification	GO:0036075	26	0.023
negative regulation of intracellular signal transduction	GO:1902532	167	0.023
peptidyl proline hydroxylation to 4 hydroxy l proline	GO:0018401	2	0.023
nucleoside phosphate catabolic process	GO:1901292	222	0.022
cell type specific apoptotic process	GO:0097285	268	0.022
epithelial cell proliferation	GO:0050673	174	0.022
regulation of hydrolase activity	GO:0051336	246	0.022
multicellular organismal homeostasis	GO:0048871	164	0.022
engulfment of apoptotic cell	GO:0043652	3	0.022
cellular amine metabolic process	GO:0044106	44	0.022
vesicle organization	GO:0016050	60	0.022
regulation of cell migration	GO:0030334	219	0.021
covalent chromatin modification	GO:0016569	163	0.021
nucleobase containing small molecule metabolic process	GO:0055086	352	0.021
blood vessel morphogenesis	GO:0048514	285	0.021
response to organonitrogen compound	GO:0010243	246	0.021
oligosaccharide biosynthetic process	GO:0009312	7	0.020
cellular component assembly involved in morphogenesis	GO:0010927	139	0.020
biomineral tissue development	GO:0031214	64	0.020
t cell activation	GO:0042110	289	0.020
regulation of cellular ketone metabolic process	GO:0010565	66	0.020
positive regulation of fatty acid oxidation	GO:0046321	4	0.020
membrane organization	GO:0061024	245	0.020
purine ribonucleotide catabolic process	GO:0009154	208	0.019
negative regulation of dna replication	GO:0008156	4	0.019
bone mineralization	GO:0030282	54	0.019
regulation of cellular amine metabolic process	GO:0033238	20	0.019
forebrain development	GO:0030900	302	0.019
regulation of cytokine production	GO:0001817	266	0.019
regulation of ossification	GO:0030278	112	0.019
regulation of peptidase activity	GO:0052547	96	0.019
regulation of endocytosis	GO:0030100	69	0.019
regulation of cellular component biogenesis	GO:0044087	181	0.018
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.018
response to decreased oxygen levels	GO:0036293	59	0.018
response to inorganic substance	GO:0010035	96	0.018
divalent inorganic cation homeostasis	GO:0072507	138	0.018
response to molecule of bacterial origin	GO:0002237	143	0.018
cellular chemical homeostasis	GO:0055082	215	0.018
negative regulation of protein metabolic process	GO:0051248	282	0.018
lipid transport	GO:0006869	98	0.018
early endosome to late endosome transport	GO:0045022	2	0.017
regulation of sphingolipid biosynthetic process	GO:0090153	1	0.017
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.017
protein heterotrimerization	GO:0070208	8	0.017
carbohydrate metabolic process	GO:0005975	230	0.017
telencephalon development	GO:0021537	186	0.017
divalent inorganic cation transport	GO:0072511	178	0.017
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	16	0.017
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.017
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.017
activation of immune response	GO:0002253	138	0.017
membrane lipid biosynthetic process	GO:0046467	32	0.017
negative regulation of type b pancreatic cell apoptotic process	GO:2000675	3	0.017
integrin mediated signaling pathway	GO:0007229	27	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.016
anatomical structure homeostasis	GO:0060249	145	0.016
regulation of mast cell differentiation	GO:0060375	3	0.016
copii coated vesicle budding	GO:0090114	2	0.016
organic anion transport	GO:0015711	137	0.016
amine metabolic process	GO:0009308	45	0.016
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.016
4 hydroxyproline metabolic process	GO:0019471	5	0.016
extracellular fibril organization	GO:0043206	2	0.016
proteoglycan metabolic process	GO:0006029	38	0.016
ribonucleotide catabolic process	GO:0009261	208	0.016
transmembrane transport	GO:0055085	412	0.016
immune response regulating signaling pathway	GO:0002764	125	0.016
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.016
organophosphate catabolic process	GO:0046434	232	0.016
response to oxygen levels	GO:0070482	62	0.015
bone morphogenesis	GO:0060349	78	0.015
regulation of proteolysis	GO:0030162	164	0.015
protein heterooligomerization	GO:0051291	14	0.015
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.015
positive regulation of cell adhesion	GO:0045785	80	0.015
mesenchymal cell differentiation	GO:0048762	107	0.015
metal ion homeostasis	GO:0055065	189	0.015
myotube differentiation	GO:0014902	105	0.015
regulation of cartilage development	GO:0061035	44	0.015
response to epidermal growth factor	GO:0070849	4	0.015
antimicrobial peptide production	GO:0002775	2	0.015
positive regulation of protein modification process	GO:0031401	299	0.015
ceramide biosynthetic process	GO:0046513	20	0.014
striated muscle tissue development	GO:0014706	293	0.014
rho protein signal transduction	GO:0007266	32	0.014
protein localization to organelle	GO:0033365	185	0.014
regulation of epithelial to mesenchymal transition	GO:0010717	22	0.014
regulation of secretion by cell	GO:1903530	249	0.014
golgi vesicle transport	GO:0048193	30	0.014
negative regulation of phosphorus metabolic process	GO:0010563	184	0.014
coagulation	GO:0050817	78	0.014
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.014
negative regulation of phagocytosis	GO:0050765	4	0.014
macromolecule catabolic process	GO:0009057	281	0.014
integrin biosynthetic process	GO:0045112	1	0.014
protein catabolic process	GO:0030163	221	0.014
protein folding	GO:0006457	28	0.014
phagocytosis	GO:0006909	66	0.014
skeletal system morphogenesis	GO:0048705	203	0.014
acetylcholine secretion neurotransmission	GO:0014055	2	0.014
purine ribonucleoside catabolic process	GO:0046130	205	0.014
multicellular organismal signaling	GO:0035637	91	0.014
i kappab kinase nf kappab signaling	GO:0007249	85	0.014
negative regulation of immune effector process	GO:0002698	55	0.014
ear development	GO:0043583	200	0.014
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.013
small molecule catabolic process	GO:0044282	71	0.013
sensory perception of mechanical stimulus	GO:0050954	107	0.013
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.013
macromolecule glycosylation	GO:0043413	55	0.013
camera type eye development	GO:0043010	266	0.013
negative regulation of molecular function	GO:0044092	258	0.013
collagen metabolic process	GO:0032963	17	0.013
fatty acid metabolic process	GO:0006631	121	0.013
negative regulation of phosphorylation	GO:0042326	166	0.013
notochord development	GO:0030903	20	0.013
response to calcium ion	GO:0051592	20	0.013
stem cell differentiation	GO:0048863	268	0.013
sensory perception	GO:0007600	245	0.013
organonitrogen compound biosynthetic process	GO:1901566	192	0.013
calcium ion homeostasis	GO:0055074	127	0.013
respiratory system development	GO:0060541	190	0.013
chondroblast differentiation	GO:0060591	2	0.013
circadian regulation of gene expression	GO:0032922	48	0.013
negative regulation of hydrolase activity	GO:0051346	71	0.013
cellular response to oxidative stress	GO:0034599	76	0.013
regulation of exit from mitosis	GO:0007096	1	0.013
nucleoside catabolic process	GO:0009164	206	0.013
regulation of system process	GO:0044057	200	0.013
regulation of endopeptidase activity	GO:0052548	89	0.012
cell recognition	GO:0008037	83	0.012
purine nucleotide metabolic process	GO:0006163	302	0.012
heterocycle catabolic process	GO:0046700	280	0.012
regulation of transferase activity	GO:0051338	263	0.012
blood coagulation	GO:0007596	76	0.012
regulation of cellular amino acid metabolic process	GO:0006521	5	0.012
retinal blood vessel morphogenesis	GO:0061304	3	0.012
multi organism reproductive behavior	GO:0044705	29	0.012
trabecula formation	GO:0060343	24	0.012
regulation of norepinephrine secretion	GO:0014061	2	0.012
regulation of interleukin 8 production	GO:0032677	3	0.012
organic hydroxy compound metabolic process	GO:1901615	203	0.012
response to organophosphorus	GO:0046683	22	0.012
multicellular organismal catabolic process	GO:0044243	7	0.012
cellular water homeostasis	GO:0009992	2	0.012
embryonic organ morphogenesis	GO:0048562	276	0.012
astrocyte fate commitment	GO:0060018	4	0.012
cardiac muscle tissue development	GO:0048738	130	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.012
appendage development	GO:0048736	166	0.012
cardiac chamber morphogenesis	GO:0003206	93	0.012
striated muscle cell development	GO:0055002	125	0.012
negative regulation of synapse maturation	GO:2000297	2	0.012
dna metabolic process	GO:0006259	303	0.011
divalent metal ion transport	GO:0070838	172	0.011
mesenchymal cell development	GO:0014031	93	0.011
histone modification	GO:0016570	159	0.011
glycoprotein biosynthetic process	GO:0009101	89	0.011
protein secretion	GO:0009306	111	0.011
cellular response to external stimulus	GO:0071496	88	0.011
regulation of oxidative phosphorylation uncoupler activity	GO:2000275	3	0.011
heart morphogenesis	GO:0003007	178	0.011
antibacterial peptide secretion	GO:0002779	1	0.011
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.011
vitamin d biosynthetic process	GO:0042368	3	0.011
regulation of cell cycle process	GO:0010564	160	0.011
regulation of ceramide biosynthetic process	GO:2000303	1	0.011
organic hydroxy compound transport	GO:0015850	93	0.011
regulation of action potential	GO:0098900	4	0.011
muscle tissue morphogenesis	GO:0060415	53	0.011
negative regulation of cellular protein metabolic process	GO:0032269	247	0.011
regulation of purine nucleotide metabolic process	GO:1900542	169	0.011
response to temperature stimulus	GO:0009266	55	0.011
positive regulation of cell motility	GO:2000147	116	0.011
regulation of ras protein signal transduction	GO:0046578	114	0.011
negative regulation of cell motility	GO:2000146	61	0.011
guanosine containing compound catabolic process	GO:1901069	144	0.011
nucleoside triphosphate catabolic process	GO:0009143	205	0.011
regulation of t cell activation	GO:0050863	170	0.011
norepinephrine transport	GO:0015874	2	0.011
positive regulation of cell migration	GO:0030335	109	0.011
phenol containing compound metabolic process	GO:0018958	60	0.011
cellular ion homeostasis	GO:0006873	165	0.011
single organism cell adhesion	GO:0098602	156	0.011
negative regulation of phosphate metabolic process	GO:0045936	184	0.011
cellular response to lipid	GO:0071396	145	0.010
mitotic cell cycle process	GO:1903047	159	0.010
cardiac muscle tissue morphogenesis	GO:0055008	44	0.010
response to metal ion	GO:0010038	47	0.010
sensory system development	GO:0048880	3	0.010
negative regulation of cell migration	GO:0030336	59	0.010
cell killing	GO:0001906	67	0.010
antimicrobial peptide biosynthetic process	GO:0002777	2	0.010
regulation of secretion	GO:0051046	274	0.010
negative regulation of macrophage chemotaxis	GO:0010760	1	0.010
t cell mediated cytotoxicity	GO:0001913	26	0.010
positive regulation of lymphocyte activation	GO:0051251	140	0.010
intussusceptive angiogenesis	GO:0002041	2	0.010
negative regulation of anoikis	GO:2000811	2	0.010
mitotic cytokinesis	GO:0000281	4	0.010
cellular response to abiotic stimulus	GO:0071214	56	0.010
sclerotome development	GO:0061056	4	0.010
regulation of protein secretion	GO:0050708	82	0.010
regulation of fibrinolysis	GO:0051917	1	0.010

Kdelr3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.505
disease of anatomical entity	DOID:7	0.505
connective tissue disease	DOID:65	0.505
bone development disease	DOID:0080006	0.221
bone disease	DOID:0080001	0.221
osteochondrodysplasia	DOID:2256	0.186
muscle tissue disease	DOID:66	0.047
myopathy	DOID:423	0.047
muscular disease	DOID:0080000	0.047
heart disease	DOID:114	0.041
cardiovascular system disease	DOID:1287	0.041
cardiomyopathy	DOID:0050700	0.041
nervous system disease	DOID:863	0.041
muscular dystrophy	DOID:9884	0.039
congenital muscular dystrophy	DOID:0050557	0.039
osteogenesis imperfecta	DOID:12347	0.034
charcot marie tooth disease	DOID:10595	0.030
neuropathy	DOID:870	0.030
neuromuscular disease	DOID:440	0.030
intrinsic cardiomyopathy	DOID:0060036	0.026
collagen disease	DOID:854	0.022
eye and adnexa disease	DOID:1492	0.018
sensory system disease	DOID:0050155	0.018
eye disease	DOID:5614	0.018
retinal degeneration	DOID:8466	0.014
retinal disease	DOID:5679	0.014

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