Mus musculus

191 known processes

Lck

lymphocyte protein tyrosine kinase

(Aliases: Lskt,p56<lck>,Lsk,p56Lck,Hck-3)

Lck biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of gamma delta t cell differentiationGO:004558860.999
t cell receptor signaling pathwayGO:0050852460.993
t cell differentiationGO:00302171740.992
leukocyte differentiationGO:00025213420.991
t cell differentiation in thymusGO:0033077770.990
positive regulation of t cell activationGO:00508701010.990
lymphocyte differentiationGO:00300982420.989
regulation of lymphocyte activationGO:00512492400.983
antigen receptor mediated signaling pathwayGO:0050851640.983
positive regulation of t cell mediated cytotoxicityGO:0001916150.981
regulation of cell activationGO:00508652890.975
positive t cell selectionGO:0043368230.974
platelet degranulationGO:000257660.967
Mouse
positive regulation of lymphocyte activationGO:00512511400.956
t cell activationGO:00421102890.947
regulation of t cell mediated cytotoxicityGO:0001914180.932
t cell selectionGO:0045058340.916
cellular amino acid metabolic processGO:00065201030.914
regulation of platelet activationGO:0010543170.910
Mouse
immune response activating cell surface receptor signaling pathwayGO:0002429720.909
regulation of leukocyte differentiationGO:19021051590.906
negative regulation of t cell mediated cytotoxicityGO:000191530.905
positive regulation of regulatory t cell differentiationGO:004559140.893
positive regulation of leukocyte differentiationGO:1902107860.892
hematopoietic stem cell migrationGO:003570110.888
thymic t cell selectionGO:0045061220.868
leukocyte apoptotic processGO:0071887710.861
Mouse
positive regulation of lymphocyte differentiationGO:0045621610.860
gamma delta t cell activationGO:0046629130.857
amine metabolic processGO:0009308450.851
positive regulation of cell activationGO:00508671580.837
regulation of t cell differentiationGO:0045580830.829
cellular amine metabolic processGO:0044106440.828
regulation of t cell anergyGO:000266740.823
fc receptor mediated stimulatory signaling pathwayGO:000243140.813
Mouse
myeloid cell homeostasisGO:00022621140.808
Mouse
negative thymic t cell selectionGO:0045060120.802
extrinsic apoptotic signaling pathwayGO:00971911260.801
positive thymic t cell selectionGO:0045059130.799
regulation of cellular amine metabolic processGO:0033238200.792
regulation of leukocyte apoptotic processGO:2000106560.787
Mouse
peptidyl tyrosine modificationGO:00182121450.781
serotonin secretion involved in inflammatory responseGO:000244240.776
positive regulation of b cell activationGO:0050871490.770
cellular ketone metabolic processGO:0042180840.768
peptidyl tyrosine phosphorylationGO:00181081430.766
positive regulation of antigen receptor mediated signaling pathwayGO:005085790.747
Mouse
positive regulation of cellular amino acid metabolic processGO:004576430.742
defense response to other organismGO:00985421970.739
Mouse
cd4 positive cd25 positive alpha beta regulatory t cell differentiationGO:000236140.738
immune response activating signal transductionGO:00027571160.734
t cell mediated cytotoxicityGO:0001913260.729
regulation of lymphocyte anergyGO:000291140.725
positive regulation of cell killingGO:0031343330.725
tyrosine phosphorylation of stat5 proteinGO:004250690.722
neutrophil activation involved in immune responseGO:000228380.720
regulation of t cell activationGO:00508631700.713
regulation of peptidyl tyrosine phosphorylationGO:0050730930.712
apoptotic signaling pathwayGO:00971903060.675
Human
regulation of cellular amino acid metabolic processGO:000652150.663
positive regulation of gamma delta t cell activationGO:004664560.653
immune effector processGO:00022523210.640
Mouse
t cell proliferationGO:00420981200.636
Mouse
interleukin 2 mediated signaling pathwayGO:003811020.626
peptidyl amino acid modificationGO:00181933360.616
gamma delta t cell differentiationGO:0042492110.600
positive regulation of cellular amine metabolic processGO:003324050.600
small gtpase mediated signal transductionGO:0007264970.600
lymphocyte mediated immunityGO:00024491390.599
leukocyte homeostasisGO:0001776790.589
Mouse
positive regulation of immune effector processGO:00026991070.577
Mouse
positive regulation of calcium mediated signalingGO:0050850150.531
positive regulation of t cell proliferationGO:0042102520.526
positive regulation of leukocyte mediated immunityGO:0002705700.518
Mouse
regulation of alpha beta t cell differentiationGO:0046637350.516
plasma membrane organizationGO:0007009900.515
leukocyte cell cell adhesionGO:0007159140.513
alpha beta t cell activationGO:0046631910.512
Mouse
regulation of transferase activityGO:00513382630.509
Mouse Fly
exocytosisGO:00068871210.507
Mouse
somatic recombination of immunoglobulin gene segmentsGO:0016447420.506
serotonin secretion by plateletGO:000255430.497
negative regulation of homeostatic processGO:0032845710.489
regulation of b cell differentiationGO:0045577230.487
adaptive immune responseGO:00022501550.477
Mouse
regulation of cellular ketone metabolic processGO:0010565660.460
defense response to virusGO:0051607680.456
negative regulation of cell adhesion involved in substrate bound cell migrationGO:000693330.453
regulation of lymphocyte differentiationGO:00456191070.450
positive regulation of type iii hypersensitivityGO:000180530.449
cytokine productionGO:00018163190.425
Mouse
cytokine mediated signaling pathwayGO:00192211150.421
actin filament organizationGO:00070151130.418
Fly
regulation of leukocyte mediated cytotoxicityGO:0001910380.418
positive regulation of peptidyl tyrosine phosphorylationGO:0050731610.416
cellular response to interleukin 15GO:007135020.416
alpha beta t cell proliferationGO:0046633210.408
somatic diversification of immune receptorsGO:0002200530.405
positive regulation of hematopoietic stem cell migrationGO:200047310.402
regulation of gamma delta t cell differentiationGO:004558690.396
gland developmentGO:00487323300.393
Mouse Fly
regulation of protein kinase activityGO:00458592320.388
Mouse Fly
neutrophil activationGO:004211990.386
leukocyte proliferationGO:00706611720.383
Mouse
regulation of alpha beta t cell proliferationGO:0046640180.383
regulation of alpha beta t cell activationGO:0046634530.378
positive regulation of lymphocyte proliferationGO:0050671700.378
regulation of homotypic cell cell adhesionGO:0034110130.377
Mouse
regulation of toll like receptor 4 signaling pathwayGO:003414340.372
Mouse
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.372
positive regulation of protein modification processGO:00314012990.369
apical constrictionGO:000338340.356
regulation of natural killer cell activationGO:0032814220.350
leukocyte mediated immunityGO:00024431740.347
Mouse
tyrosine phosphorylation of stat proteinGO:0007260230.346
endodermal cell fate specificationGO:000171440.341
Worm
regulation of defense responseGO:00313472330.340
Mouse
regulation of map kinase activityGO:00434051200.339
Mouse
regulation of type iia hypersensitivityGO:000179640.336
positive regulation of protein phosphorylationGO:00019342420.329
regulation of phagocytosisGO:0050764330.328
Mouse
positive regulation of t cell differentiationGO:0045582520.323
negative t cell selectionGO:0043383130.321
regulation of cell killingGO:0031341400.314
positive regulation of cell deathGO:00109422240.313
Human Mouse
positive regulation of protein kinase activityGO:00458601440.310
Fly
antigen processing and presentation of peptide antigen via mhc class iGO:000247490.310
positive regulation of kinase activityGO:00336741550.296
Mouse Fly
second messenger mediated signalingGO:0019932730.292
homeostasis of number of cellsGO:00488722100.290
Mouse
regulation of cell migrationGO:00303342190.289
Mouse
regulation of apoptotic signaling pathwayGO:20012331970.288
Human
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.287
regulation of lymphocyte apoptotic processGO:0070228410.282
Mouse
serotonin production involved in inflammatory responseGO:000235140.281
somatic cell dna recombinationGO:0016444510.281
negative regulation of insulin receptor signaling pathwayGO:0046627140.274
bone marrow developmentGO:004853930.273
cell fate commitmentGO:00451652100.272
Worm
modulation by virus of host processGO:001905420.272
divalent inorganic cation transportGO:00725111780.271
lymphocyte anergyGO:000224940.271
positive regulation of type ii hypersensitivityGO:000289440.268
regulation of adaptive immune responseGO:0002819900.267
regulation of homeostatic processGO:00328441820.266
lymphocyte apoptotic processGO:0070227540.266
Mouse
protein localization to plasma membraneGO:0072659570.264
granulocyte activationGO:0036230100.263
protein localization to nucleusGO:00345041210.263
Mouse
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.259
lymphocyte homeostasisGO:0002260640.258
Mouse
t cell anergyGO:000287040.254
protein localization to membraneGO:00726571080.251
regulation of mast cell activationGO:0033003210.251
Mouse
regulation of kinase activityGO:00435492490.248
Mouse Fly
single organismal cell cell adhesionGO:00163371310.247
Mouse Fly
leukocyte activation involved in immune responseGO:00023661260.246
Mouse
antigen processing and presentation of exogenous peptide antigenGO:0002478210.243
positive regulation of defense responseGO:00313491240.240
Mouse
positive regulation of stress activated mapk cascadeGO:0032874480.240
regulation of dendritic cell apoptotic processGO:200066830.238
Mouse
positive regulation of podosome assemblyGO:007180330.237
Mouse
signal transduction in absence of ligandGO:0038034550.236
protein autophosphorylationGO:0046777610.236
regulation of endocytosisGO:0030100690.235
Mouse
blood coagulationGO:0007596760.234
Mouse
regulation of t cell proliferationGO:0042129920.233
calcium mediated signalingGO:0019722460.230
protein importGO:00170381010.229
canonical wnt signaling pathwayGO:00600701300.223
Mouse
b cell proliferationGO:0042100530.223
Mouse
fc receptor mediated inhibitory signaling pathwayGO:000277410.223
Mouse
protein localization to organelleGO:00333651850.218
Mouse
integrin mediated signaling pathwayGO:0007229270.216
Mouse
cytoplasmic transportGO:00164822340.214
negative regulation of myeloid leukocyte differentiationGO:0002762200.212
Mouse
regulation of calcium mediated signalingGO:0050848190.202
activation of immune responseGO:00022531380.201
membrane organizationGO:00610242450.198
regulation of interferon gamma productionGO:0032649570.191
regulation of cytokine productionGO:00018172660.189
Mouse
positive regulation of mast cell activation involved in immune responseGO:0033008100.188
Mouse
response to organonitrogen compoundGO:00102432460.186
positive regulation of transferase activityGO:00513471670.186
Mouse Fly
regulation of leukocyte proliferationGO:00706631210.183
Mouse
myeloid leukocyte differentiationGO:00025731190.183
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.180
organelle localizationGO:00516401790.180
Mouse Worm
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.179
leukocyte degranulationGO:0043299270.179
Mouse
regulation of secretion by cellGO:19035302490.168
Mouse
regulation of tyrosine phosphorylation of stat5 proteinGO:004252280.167
immune response inhibiting cell surface receptor signaling pathwayGO:000276730.166
Mouse
activation of phospholipase c activityGO:000720220.165
Mouse
cell adhesionGO:00071553290.164
Mouse Fly
negative regulation of peptidyl tyrosine phosphorylationGO:0050732170.153
endomembrane system organizationGO:00102561470.152
fc epsilon receptor signaling pathwayGO:003809530.149
b cell differentiationGO:0030183780.148
nitrogen compound transportGO:00717052710.145
regulation of intracellular transportGO:00323861590.144
Mouse
nuclear transportGO:00511691390.144
regulation of regulatory t cell differentiationGO:004558970.144
inflammatory response to antigenic stimulusGO:0002437300.141
stem cell developmentGO:00488642190.140
antigen processing and presentation of exogenous antigenGO:0019884260.138
positive regulation of interleukin 6 productionGO:0032755370.137
regulation of t cell mediated immunityGO:0002709340.136
negative regulation of t cell mediated immunityGO:000271090.135
regulation of phospholipase c activityGO:190027430.134
Mouse
dna metabolic processGO:00062593030.133
immunoglobulin production involved in immunoglobulin mediated immune responseGO:0002381430.133
regulation of neuron differentiationGO:00456642810.132
Mouse
ras protein signal transductionGO:0007265770.130
regulation of mast cell degranulationGO:0043304160.130
Mouse
positive regulation of b cell receptor signaling pathwayGO:005086140.129
Mouse
regulation of production of molecular mediator of immune responseGO:0002700650.128
b cell receptor signaling pathwayGO:0050853200.127
cation transportGO:00068123990.126
regulation of myeloid cell differentiationGO:0045637960.125
Mouse
mast cell activation involved in immune responseGO:0002279200.123
Mouse
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.120
striated muscle cell developmentGO:00550021250.120
regulation of inflammatory responseGO:00507271470.119
Mouse
regulation of coagulationGO:0050818310.119
Mouse
lymphocyte activation involved in immune responseGO:0002285930.118
positive regulation of leukocyte proliferationGO:0070665730.116
regulation of type ii hypersensitivityGO:000289240.115
endocytosisGO:00068971680.113
Mouse
positive regulation of hydrolase activityGO:00513451480.113
Human Mouse
production of molecular mediator of immune responseGO:00024401030.112
positive regulation of cytokine productionGO:00018191740.112
Mouse
positive regulation of tyrosine phosphorylation of stat5 proteinGO:004252360.111
positive regulation of t cell mediated immunityGO:0002711240.110
positive regulation of alpha beta t cell differentiationGO:0046638280.110
b cell activation involved in immune responseGO:0002312500.108
positive regulation of lymphocyte anergyGO:000291340.107
regulation of hemostasisGO:1900046280.107
Mouse
regulation of lymphocyte proliferationGO:00506701170.106
Mouse
positive regulation of apoptotic signaling pathwayGO:2001235950.105
Human
cation homeostasisGO:00550802120.104
negative regulation of transferase activityGO:0051348850.101
Mouse
neuron migrationGO:00017641220.100
Mouse
positive regulation of adaptive immune responseGO:0002821610.100
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.100
toll like receptor 4 signaling pathwayGO:003414290.099
Mouse
positive regulation of immunoglobulin mediated immune responseGO:0002891260.097
t cell mediated immunityGO:0002456500.096
regulation of type iii hypersensitivityGO:000180330.096
jak stat cascadeGO:0007259420.095
positive regulation of programmed cell deathGO:00430682180.095
Human Mouse
regulation of stress activated mapk cascadeGO:0032872690.095
olfactory learningGO:000835520.095
Fly
myeloid leukocyte activationGO:0002274830.095
Mouse
erythrocyte differentiationGO:0030218880.095
Mouse
positive regulation of innate immune responseGO:0045089800.093
Mouse
wnt signaling pathwayGO:00160551880.092
Mouse
dendritic spine maintenanceGO:009706240.092
stress activated protein kinase signaling cascadeGO:0031098810.092
regulation of synaptic growth at neuromuscular junctionGO:000858240.091
Fly
positive regulation of alpha beta t cell activationGO:0046635390.090
positive regulation of dendritic cell apoptotic processGO:200067030.090
Mouse
homotypic cell cell adhesionGO:0034109280.090
Mouse
mammary gland epithelium developmentGO:0061180650.089
Mouse
regulation of jnk cascadeGO:0046328620.088
activation of janus kinase activityGO:004297620.088
positive regulation of leukocyte degranulationGO:0043302100.088
Mouse
regulation of cytokine production involved in immune responseGO:0002718260.087
regulation of actin filament based processGO:0032970990.087
Fly
jnk cascadeGO:0007254720.086
dendritic spine organizationGO:0097061260.086
response to molecule of fungal originGO:000223840.086
positive regulation of intracellular transportGO:0032388700.085
Mouse
regulation of stem cell proliferationGO:0072091780.085
alpha beta t cell differentiationGO:0046632690.085
Mouse
regulation of lymphocyte mediated immunityGO:0002706840.084
cellular response to cytokine stimulusGO:00713451890.083
negative regulation of mast cell proliferationGO:007066710.082
Mouse
positive regulation of growth hormone receptor signaling pathwayGO:006039930.081
regulation of tyrosine phosphorylation of stat proteinGO:0042509200.081
negative regulation of t cell apoptotic processGO:0070233180.081
negative regulation of leukocyte apoptotic processGO:2000107310.081
protein processingGO:00164851630.080
Human
positive regulation of t cell anergyGO:000266940.080
regulation of phosphatidylinositol 3 kinase signalingGO:0014066300.080
striated muscle tissue developmentGO:00147062930.080
actin polymerization or depolymerizationGO:0008154540.079
Fly
cellular protein complex assemblyGO:00436231160.079
protein lipidationGO:0006497280.079
myeloid leukocyte migrationGO:0097529570.079
b cell activationGO:00421131610.079
Mouse
membrane invaginationGO:0010324170.078
negative regulation of synapse assemblyGO:005196430.077
Fly
regulation of anatomical structure sizeGO:00900661780.076
Fly
skeletal system developmentGO:00015013560.076
sequestering of calcium ionGO:0051208180.076
antigen processing and presentation of peptide antigenGO:0048002290.075
response to molecule of bacterial originGO:00022371430.074
Mouse
interferon gamma productionGO:0032609670.073
Mouse
phagocytosisGO:0006909660.073
Mouse
negative regulation of erk1 and erk2 cascadeGO:0070373210.073
Mouse
regulation of exocytosisGO:0017157610.072
Mouse
i kappab kinase nf kappab signalingGO:0007249850.072
Mouse
calcium ion homeostasisGO:00550741270.072
regulation of wound healingGO:0061041400.072
Mouse
regulation of wnt signaling pathwayGO:00301111230.072
Mouse
positive regulation of cytosolic calcium ion concentrationGO:0007204650.072
fc receptor signaling pathwayGO:003809360.071
gonad developmentGO:00084061410.071
Worm
regionalizationGO:00030023370.071
negative regulation of adaptive immune responseGO:0002820250.071
somatic recombination of immunoglobulin genes involved in immune responseGO:0002204360.071
modulation by virus of host morphology or physiologyGO:001904830.070
immune response regulating cell surface receptor signaling pathwayGO:0002768800.070
transmembrane receptor protein tyrosine phosphatase signaling pathwayGO:000718510.070
regulation of protein import into nucleusGO:0042306520.070
wound healingGO:00420601570.070
Mouse
protein maturationGO:00516041760.069
Human
regulation of proteolysisGO:00301621640.069
Human
b cell apoptotic processGO:0001783190.068
Mouse
positive regulation of leukocyte apoptotic processGO:2000108210.067
Mouse
neutrophil degranulationGO:004331260.067
nucleocytoplasmic transportGO:00069131390.067
isotype switchingGO:0045190360.067
regulation of podosome assemblyGO:007180130.066
Mouse
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002823230.066
cell killingGO:0001906670.066
negative regulation of response to cytokine stimulusGO:006076190.065
compound eye developmentGO:004874910.065
bone remodelingGO:0046849530.065
Mouse
regulation of membrane potentialGO:00423911920.064
regulation of myeloid leukocyte differentiationGO:0002761580.064
Mouse
regulation of b cell mediated immunityGO:0002712370.064
regulation of cellular component sizeGO:00325351210.063
Fly
regulation of actin filament polymerizationGO:0030833380.063
dna recombinationGO:0006310920.063
negative regulation of b cell proliferationGO:0030889130.063
Mouse
actin cytoskeleton organizationGO:00300362200.063
Fly
protein import into nucleusGO:0006606950.063
regulation of mast cell proliferationGO:007066640.062
Mouse
positive regulation of alpha beta t cell proliferationGO:0046641120.062
actin filament based movementGO:0030048230.062
regulation of acute inflammatory responseGO:0002673270.062
cellular response to acid chemicalGO:0071229680.061
Mouse
regulation of myeloid leukocyte mediated immunityGO:0002886250.061
Mouse
intracellular protein transportGO:00068862040.061
lymphocyte proliferationGO:00466511640.060
Mouse
cd4 positive alpha beta t cell activationGO:0035710450.060
activation of mapk activityGO:0000187590.060
regulation of t cell receptor signaling pathwayGO:0050856210.060
regulation of actin filament lengthGO:0030832450.060
Fly
regulation of leukocyte degranulationGO:0043300200.059
Mouse
organelle assemblyGO:00709251770.059
Mouse
regulation of protein transportGO:00512231630.059
Mouse
podosome assemblyGO:007180060.059
Mouse
sequestering of metal ionGO:0051238190.058
positive regulation of b cell differentiationGO:0045579130.058
regulation of protein autophosphorylationGO:003195280.058
regulation of interleukin 6 productionGO:0032675550.057
response to acid chemicalGO:00011011110.057
Mouse
cellular response to hormone stimulusGO:00328701500.057
regulation of canonical wnt signaling pathwayGO:0060828820.057
Mouse
regulation of cell adhesionGO:00301551540.057
Mouse
somatic diversification of immunoglobulins involved in immune responseGO:0002208360.057
regulation of cell cycleGO:00517262810.056
regulation of ion homeostasisGO:2000021640.056
establishment or maintenance of cell polarityGO:0007163860.056
Worm
antigen processing and presentation of exogenous peptide antigen via mhc class iiGO:0019886140.056
positive regulation of acute inflammatory responseGO:0002675160.056
mast cell activationGO:0045576270.056
Mouse
regulation of hydrolase activityGO:00513362460.056
Human Mouse
positive regulation of granulocyte macrophage colony stimulating factor biosynthetic processGO:004542520.055
zymogen activationGO:0031638410.055
Human
memoryGO:0007613580.054
Fly
negative regulation of cellular amino acid metabolic processGO:004576300.054
cell type specific apoptotic processGO:00972852680.054
Mouse
maintenance of locationGO:0051235890.054
erk1 and erk2 cascadeGO:0070371770.053
Mouse
positive regulation of response to woundingGO:1903036660.053
regulation of type i hypersensitivityGO:000181040.053
single organism nuclear importGO:1902593950.052
positive regulation of cytoskeleton organizationGO:0051495490.052
interleukin 6 productionGO:0032635580.052
dephosphorylationGO:00163111290.052
Human
positive regulation of map kinase activityGO:0043406840.052
positive regulation of mast cell activationGO:0033005120.052
Mouse
sensory perceptionGO:00076002450.051
Mouse
positive regulation of intracellular protein transportGO:0090316420.051
positive regulation of type i hypersensitivityGO:000181230.051
protein targetingGO:00066051430.051
positive regulation of translational initiationGO:004594840.050
salivary gland developmentGO:0007431370.050
Fly
establishment of protein localization to organelleGO:00725941180.049
positive regulation of lymphocyte mediated immunityGO:0002708620.049
somatic diversification of immunoglobulinsGO:0016445430.049
regulation of b cell activationGO:0050864810.049
Mouse
mast cell homeostasisGO:003302350.048
positive regulation of myeloid leukocyte cytokine production involved in immune responseGO:006108190.048
actin mediated cell contractionGO:0070252150.048
epithelial cell migrationGO:0010631630.048
cellularizationGO:000734910.047
Fly
neuron projection extensionGO:1990138640.047
regulation of cytoskeleton organizationGO:00514931220.047
Fly
detection of mechanical stimulus involved in sensory perception of painGO:005096640.047
Mouse
stem cell differentiationGO:00488632680.047
smoothened signaling pathwayGO:00072241050.046
positive regulation of exocytosisGO:0045921200.046
Mouse
phosphatidylinositol 3 kinase signalingGO:0014065360.046
negative regulation of lymphocyte apoptotic processGO:0070229240.046
positive regulation of canonical wnt signaling pathwayGO:0090263290.046
Mouse
actin filament polymerizationGO:0030041440.046
regulation of immunoglobulin mediated immune responseGO:0002889370.046
t cell homeostatic proliferationGO:000177740.045
motor neuron axon guidanceGO:0008045260.045
lysosome localizationGO:0032418200.045
Mouse
neuron projection guidanceGO:00974851410.045
Fly
regulation of hematopoietic stem cell migrationGO:200047110.045
heterotypic cell cell adhesionGO:003411370.045
negative regulation of t cell activationGO:0050868650.044
axon guidanceGO:00074111410.044
Fly
positive regulation of type iia hypersensitivityGO:000179840.044
negative regulation of toll like receptor signaling pathwayGO:0034122140.044
Mouse
protein catabolic processGO:00301632210.044
Mouse
positive regulation of protein serine threonine kinase activityGO:00719021060.044
positive regulation of cell adhesionGO:0045785800.044
response to stem cell factorGO:003621530.044
regulation of tumor necrosis factor productionGO:0032680490.043
cd4 positive alpha beta t cell differentiationGO:0043367410.043
response to ionizing radiationGO:0010212420.043
cellular response to peptide hormone stimulusGO:0071375920.043
positive regulation of interleukin 8 secretionGO:200048410.042
regulation of tissue remodelingGO:0034103380.042
t cell receptor v d j recombinationGO:003315350.042
substrate dependent cell migration cell extensionGO:000693040.041
regulation of dendritic cell cytokine productionGO:000273020.041
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.041
synapse assemblyGO:0007416560.041
Fly
cellular ion homeostasisGO:00068731650.041
natural killer cell proliferationGO:000178730.041
positive regulation of interferon gamma productionGO:0032729390.041
negative regulation of protein phosphorylationGO:00019331260.040
Mouse
stem cell maintenanceGO:00198271300.040
antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:0002504170.040
maintenance of location in cellGO:0051651240.040
interleukin 8 secretionGO:007260630.039
positive regulation of t cell costimulationGO:200052520.039
regulation of cell cycle processGO:00105641600.039
cellular response to molecule of fungal originGO:007122620.039
negative regulation of protein autophosphorylationGO:003195320.039
regulation of interferon gamma secretionGO:190271330.038
positive regulation of b cell proliferationGO:0030890240.038
positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292560.038
cellular response to organonitrogen compoundGO:00714171450.038
response to radiationGO:00093141650.038
regulation of mapk cascadeGO:00434082480.038
Mouse
male gamete generationGO:00482322850.038
regulation of cd4 positive alpha beta t cell differentiationGO:0043370210.038
myeloid leukocyte cytokine productionGO:0061082120.038
protein polymerizationGO:0051258570.037
regulation of action potentialGO:009890040.037
peptidyl serine phosphorylationGO:0018105740.037
positive regulation of cell developmentGO:00107202370.037
Mouse
mast cell mediated immunityGO:0002448200.037
Mouse
positive regulation of nucleocytoplasmic transportGO:0046824300.036
rac protein signal transductionGO:0016601130.036
mapk cascadeGO:00001652810.036
Mouse
regulation of insulin receptor signaling pathwayGO:0046626210.036
coagulationGO:0050817780.036
Mouse
negative regulation of nervous system developmentGO:00519611560.036
Fly
forebrain developmentGO:00309003020.035
Mouse
positive regulation of jnk cascadeGO:0046330460.035
regulation of cysteine type endopeptidase activityGO:2000116650.035
Human
t cell differentiation involved in immune responseGO:0002292300.035
positive regulation of cytokine secretionGO:0050715410.035
Mouse
axonogenesisGO:00074092740.035
Fly
asymmetric neuroblast divisionGO:005505910.035
positive regulation of phospholipase c activityGO:001086320.035
Mouse
positive regulation of phosphatidylinositol 3 kinase signalingGO:0014068200.035
positive regulation of tyrosine phosphorylation of stat proteinGO:0042531150.035
positive regulation of stem cell proliferationGO:2000648590.034
cellular response to peptideGO:1901653920.034
interspecies interaction between organismsGO:0044419830.034
t cell apoptotic processGO:0070231390.034
single organism cell adhesionGO:00986021560.034
Mouse Fly
negative regulation of apoptotic signaling pathwayGO:20012341040.034
maintenance of protein location in cellGO:0032507200.034
engulfment of apoptotic cellGO:004365230.034
leukocyte mediated cytotoxicityGO:0001909620.033
regulation of mitotic cell cycleGO:00073461260.033
cellular divalent inorganic cation homeostasisGO:00725031270.033
positive regulation of jun kinase activityGO:0043507300.033
intracellular steroid hormone receptor signaling pathwayGO:0030518290.033
Mouse
skeletal muscle organ developmentGO:00605381630.033
stem cell proliferationGO:00720891170.033

Lck disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
severe combined immunodeficiencyDOID:62700.135
combined t cell and b cell immunodeficiencyDOID:62800.135
immune system diseaseDOID:291400.135
disease of anatomical entityDOID:700.135
primary immunodeficiency diseaseDOID:61200.135