Mus musculus

89 known processes

Mcl1

myeloid cell leukemia sequence 1

(Aliases: AW556805,Mcl-1)

Mcl1 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of mitochondrial membrane permeability involved in apoptotic processGO:1902110110.996
Mouse
release of cytochrome c from mitochondriaGO:0001836230.964
Mouse
negative regulation of cell proliferationGO:00082852960.926
Mouse
positive regulation of mitochondrion organizationGO:0010822170.926
Worm
positive regulation of cell deathGO:00109422240.923
regulation of mitochondrion organizationGO:0010821270.915
Worm
positive regulation of release of cytochrome c from mitochondriaGO:009020050.914
homeostasis of number of cellsGO:00488722100.890
Mouse
reactive oxygen species metabolic processGO:0072593840.890
Mouse
cellular response to dna damage stimulusGO:00069742070.876
lymphocyte homeostasisGO:0002260640.854
Mouse
positive regulation of mitochondrial membrane permeabilityGO:0035794120.844
Mouse
positive regulation of programmed cell deathGO:00430682180.843
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.839
amine metabolic processGO:0009308450.827
negative regulation of cellular amine metabolic processGO:003323910.817
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayGO:190103060.806
mitochondrial membrane organizationGO:0007006260.803
Mouse
apoptotic mitochondrial changesGO:0008637480.801
response to organic cyclic compoundGO:00140701980.800
Mouse
negative regulation of fibroblast proliferationGO:0048147140.799
Mouse
response to ionizing radiationGO:0010212420.794
Mouse
regulation of cysteine type endopeptidase activityGO:2000116650.777
Zebrafish Mouse
immune effector processGO:00022523210.764
response to organonitrogen compoundGO:00102432460.761
Mouse
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332350.758
Mouse
mitochondrial transportGO:0006839360.758
Mouse
positive regulation of cysteine type endopeptidase activityGO:2001056390.756
Mouse
leukocyte differentiationGO:00025213420.744
Mouse
positive regulation of endopeptidase activityGO:0010950430.734
Mouse
positive regulation of apoptotic processGO:00430652170.702
regulation of apoptotic signaling pathwayGO:20012331970.695
cellular response to organonitrogen compoundGO:00714171450.687
Mouse
positive regulation of proteolysisGO:0045862850.681
Mouse
regulation of cellular ketone metabolic processGO:0010565660.681
activation of immune responseGO:00022531380.671
extrinsic apoptotic signaling pathwayGO:00971911260.670
t cell activationGO:00421102890.656
Mouse
positive regulation of apoptotic signaling pathwayGO:2001235950.655
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.653
Zebrafish Mouse
camera type eye developmentGO:00430102660.645
Mouse
regulation of endopeptidase activityGO:0052548890.639
Zebrafish Mouse
regulation of cellular amino acid metabolic processGO:000652150.632
cellular macromolecule catabolic processGO:00442652060.630
regulation of mitochondrial membrane permeability involved in apoptotic processGO:1902108140.628
Mouse
positive regulation of protein oligomerizationGO:003246140.623
t cell differentiation in thymusGO:0033077770.611
Mouse
regulation of mitochondrial membrane permeabilityGO:0046902170.611
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.594
Mouse
macromolecule catabolic processGO:00090572810.583
establishment of protein localization to organelleGO:00725941180.583
Mouse
t cell homeostasisGO:0043029350.581
Mouse
positive regulation of peptidase activityGO:0010952490.566
Mouse
intrinsic apoptotic signaling pathwayGO:00971931320.563
protein localization to membraneGO:00726571080.563
Mouse
establishment of protein localization to membraneGO:0090150540.555
Mouse
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074030.554
mitochondrion organizationGO:00070051340.551
cellular response to glucose starvationGO:004214950.547
Mouse
response to oxygen levelsGO:0070482620.539
Mouse
mitochondrial outer membrane permeabilizationGO:0097345100.534
Mouse
protein processingGO:00164851630.530
Zebrafish Mouse
protein maturationGO:00516041760.525
Zebrafish Mouse
activation of cysteine type endopeptidase activityGO:0097202270.519
Mouse
cellular response to starvationGO:0009267570.513
Mouse
t cell differentiationGO:00302171740.512
Mouse
immune response regulating signaling pathwayGO:00027641250.503
blood vessel morphogenesisGO:00485142850.499
Mouse
regulation of cellular response to stressGO:00801351590.495
positive regulation of neuron apoptotic processGO:0043525250.495
establishment of protein localization to mitochondrionGO:0072655110.494
Mouse
response to hypoxiaGO:0001666580.483
Mouse
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.482
Mouse
symbiosis encompassing mutualism through parasitismGO:0044403830.475
Mouse
regulation of hydrolase activityGO:00513362460.450
Zebrafish Mouse Worm
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.449
Human Mouse
regulation of establishment of protein localizationGO:00702011810.447
regulation of intracellular transportGO:00323861590.443
Mouse
response to dsrnaGO:0043331300.442
response to oxidative stressGO:00069791230.436
positive regulation of neuron deathGO:1901216280.435
protein insertion into mitochondrial membraneGO:005120440.430
Mouse
defense response to other organismGO:00985421970.429
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244250.422
apoptotic signaling pathwayGO:00971903060.419
cellular amino acid metabolic processGO:00065201030.413
protein catabolic processGO:00301632210.408
fibroblast proliferationGO:0048144350.392
Mouse
protein modification by small protein conjugationGO:00324461870.391
cell type specific apoptotic processGO:00972852680.390
lymphocyte differentiationGO:00300982420.384
Mouse
lymphocyte proliferationGO:00466511640.378
Mouse
immune response activating signal transductionGO:00027571160.364
cellular protein catabolic processGO:00442571550.359
positive regulation of protein modification processGO:00314012990.359
Mouse
myeloid cell differentiationGO:00300992330.357
interspecies interaction between organismsGO:0044419830.352
Mouse
gland developmentGO:00487323300.347
Mouse
nucleoside metabolic processGO:00091162460.334
Worm
defense response to virusGO:0051607680.331
myeloid leukocyte differentiationGO:00025731190.324
membrane organizationGO:00610242450.322
Mouse Worm
regulation of leukocyte differentiationGO:19021051590.321
regulation of protein localizationGO:00328802310.317
Mouse
cellular response to oxygen levelsGO:0071453200.314
Mouse
response to radiationGO:00093141650.314
Mouse
leukocyte homeostasisGO:0001776790.313
Mouse
positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902043130.307
negative regulation of protein metabolic processGO:00512482820.303
Zebrafish Mouse
neuron apoptotic processGO:00514021420.301
regulation of release of cytochrome c from mitochondriaGO:0090199110.300
regulation of lymphocyte activationGO:00512492400.296
peptidyl lysine modificationGO:0018205770.294
regulation of cellular amine metabolic processGO:0033238200.288
gene silencing by mirnaGO:0035195100.281
regulation of inflammatory responseGO:00507271470.277
cellular response to extracellular stimulusGO:0031668810.276
Mouse
regulation of fibroblast proliferationGO:0048145340.273
Mouse
regulation of neuron apoptotic processGO:00435231220.272
zymogen activationGO:0031638410.269
Mouse
response to peptideGO:19016521360.259
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.255
epidermis developmentGO:00085441870.252
Mouse
regulation of multi organism processGO:00439001110.249
Mouse
osteoclast differentiationGO:0030316620.247
regulation of membrane potentialGO:00423911920.246
Mouse
cellular response to oxidative stressGO:0034599760.241
methylationGO:00322591340.240
cellular nitrogen compound catabolic processGO:00442702800.239
Worm
regulation of organelle organizationGO:00330432890.238
Zebrafish Worm
glycosyl compound metabolic processGO:19016572460.235
Worm
positive regulation of organelle organizationGO:00106381280.232
Worm
regulation of cytokine productionGO:00018172660.229
positive regulation of hydrolase activityGO:00513451480.228
Mouse Worm
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.221
Mouse
single organism cell adhesionGO:00986021560.220
Mouse
nucleobase containing small molecule metabolic processGO:00550863520.219
Worm
regulation of peptidase activityGO:0052547960.215
Zebrafish Mouse
negative regulation of phosphorus metabolic processGO:00105631840.212
Mouse
striated muscle tissue developmentGO:00147062930.212
Mouse
multicellular organism growthGO:00352641610.211
Mouse
regulation of t cell activationGO:00508631700.207
response to x rayGO:0010165110.207
response to peptide hormoneGO:00434341270.206
regulation of mitochondrial membrane potentialGO:0051881170.206
Mouse
protein localization to organelleGO:00333651850.199
Mouse
positive regulation of leukocyte differentiationGO:1902107860.199
developmental maturationGO:00217001930.198
Mouse
regulation of organ morphogenesisGO:20000271440.197
Mouse
organic cyclic compound catabolic processGO:19013612950.196
Worm
proteolysis involved in cellular protein catabolic processGO:00516031470.195
stem cell maintenanceGO:00198271300.193
cytokine productionGO:00018163190.192
muscle tissue developmentGO:00605373080.188
Mouse
cellular amine metabolic processGO:0044106440.187
renal system developmentGO:00720012250.182
Mouse
angiogenesisGO:00015252010.178
Mouse
response to starvationGO:0042594650.177
Mouse
negative regulation of protein modification processGO:00314001630.175
Mouse
regulation of myeloid leukocyte differentiationGO:0002761580.175
nucleotide catabolic processGO:00091662170.174
Worm
protein ubiquitinationGO:00165671710.174
striated muscle cell developmentGO:00550021250.172
Mouse
skin developmentGO:00435882200.169
Mouse
positive regulation of cell developmentGO:00107202370.167
Mouse
stem cell developmentGO:00488642190.167
Mouse
heterocycle catabolic processGO:00467002800.164
Worm
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919270.163
Mouse
negative regulation of membrane potentialGO:004583740.163
protein methylationGO:0006479810.159
modification dependent protein catabolic processGO:00199411330.158
protein modification by small protein conjugation or removalGO:00706472070.156
peptidyl amino acid modificationGO:00181933360.155
Mouse
axonogenesisGO:00074092740.155
Mouse
protein oligomerizationGO:0051259670.155
Mouse
regulation of myotube differentiationGO:0010830620.154
Mouse
regulation of neuron deathGO:19012141340.153
negative regulation of cellular amino acid metabolic processGO:004576300.153
innate immune responseGO:00450871570.150
protein localization to nucleusGO:00345041210.148
regulation of myeloid cell differentiationGO:0045637960.147
regulation of developmental pigmentationGO:0048070140.143
Mouse
positive regulation of myeloid leukocyte differentiationGO:0002763260.143
negative regulation of phosphate metabolic processGO:00459361840.142
Mouse
response to light stimulusGO:00094161350.141
Mouse
regulation of cellular component biogenesisGO:00440871810.139
monosaccharide metabolic processGO:00059961060.139
cellular ketone metabolic processGO:0042180840.139
positive regulation of protein complex assemblyGO:0031334450.136
respiratory tube developmentGO:00303231670.135
muscle cell developmentGO:00550011330.135
Mouse
protein acylationGO:0043543640.135
skeletal muscle organ developmentGO:00605381630.131
Mouse
regulation of proteolysisGO:00301621640.127
Zebrafish Mouse
morphogenesis of a branching epitheliumGO:00611381930.125
Mouse
skeletal muscle fiber developmentGO:0048741580.124
Mouse
regulation of innate immune responseGO:0045088910.124
stem cell differentiationGO:00488632680.124
Mouse
regulation of glucose metabolic processGO:0010906600.123
positive regulation of cellular component biogenesisGO:0044089940.122
organonitrogen compound catabolic processGO:19015652640.121
Worm
purine nucleoside triphosphate metabolic processGO:00091442260.121
Worm
peptidyl serine modificationGO:0018209830.121
Mouse
viral processGO:0016032410.119
Mouse
mammary gland epithelium developmentGO:0061180650.119
Mouse
digestive tract developmentGO:00485651900.118
Mouse
proteasomal protein catabolic processGO:0010498980.118
innate immune response activating signal transductionGO:0002758500.117
regulation of protein transportGO:00512231630.117
hemostasisGO:0007599780.117
erk1 and erk2 cascadeGO:0070371770.116
macromolecule methylationGO:00434141200.114
negative regulation of cellular protein metabolic processGO:00322692470.112
Zebrafish Mouse
peptidyl tyrosine modificationGO:00182121450.111
digestive system developmentGO:00551232000.109
Mouse
alpha beta t cell differentiationGO:0046632690.109
Mouse
adaptive immune responseGO:00022501550.107
respiratory system developmentGO:00605411900.107
negative regulation of intracellular signal transductionGO:19025321670.107
fat cell differentiationGO:00454441600.107
carbohydrate metabolic processGO:00059752300.105
regulation of body fluid levelsGO:00508781620.105
monosaccharide transportGO:0015749580.105
membrane lipid metabolic processGO:0006643530.104
Mouse
positive regulation of cytokine productionGO:00018191740.102
regulation of reactive oxygen species metabolic processGO:2000377400.102
positive regulation of myeloid cell differentiationGO:0045639430.101
purine ribonucleotide metabolic processGO:00091502900.101
Worm
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.100
Mouse
epithelial cell developmentGO:00020641590.099
response to superoxideGO:0000303160.099
cellular response to peptideGO:1901653920.099
positive regulation of protein phosphorylationGO:00019342420.098
Mouse
lymphocyte mediated immunityGO:00024491390.097
positive regulation of lymphocyte activationGO:00512511400.095
negative regulation of peptidyl serine phosphorylationGO:0033137100.095
Mouse
regulation of peptidyl lysine acetylationGO:2000756220.094
spongiotrophoblast layer developmentGO:0060712150.094
purine nucleoside triphosphate catabolic processGO:00091462030.094
Worm
embryonic placenta developmentGO:0001892980.094
synaptic transmissionGO:00072683290.094
urogenital system developmentGO:00016552610.094
Mouse
cation transportGO:00068123990.094
Mouse
limb morphogenesisGO:00351081490.091
Mouse
fibroblast apoptotic processGO:004434690.091
Mouse
cellular response to oxygen radicalGO:0071450140.091
positive regulation of response to dna damage stimulusGO:2001022140.091
endocytosisGO:00068971680.090
regulation of mapk cascadeGO:00434082480.088
regulation of alpha beta t cell differentiationGO:0046637350.087
response to hydrogen peroxideGO:0042542320.087
Mouse
leukocyte activation involved in immune responseGO:00023661260.086
thymus developmentGO:0048538410.086
Mouse
regulation of muscle tissue developmentGO:1901861970.086
Mouse
positive regulation of neuron differentiationGO:00456661410.086
Mouse
negative regulation of neuron apoptotic processGO:0043524920.085
Mouse
regulation of protein kinase activityGO:00458592320.084
regulation of b cell apoptotic processGO:0002902130.084
Mouse
positive regulation of interferon alpha productionGO:003272740.084
ubiquitin dependent protein catabolic processGO:00065111290.084
post embryonic camera type eye developmentGO:003107780.082
Mouse
purine nucleoside metabolic processGO:00422782410.082
Worm
leukocyte proliferationGO:00706611720.082
Mouse
regulation of removal of superoxide radicalsGO:200012140.081
negative regulation of protein phosphorylationGO:00019331260.081
Mouse
nitrogen compound transportGO:00717052710.079
cellular response to hypoxiaGO:0071456170.078
Mouse
ribonucleoside metabolic processGO:00091192450.077
Worm
regulation of cell projection assemblyGO:0060491380.075
response to molecule of bacterial originGO:00022371430.075
chromatin modificationGO:00165681870.075
response to inorganic substanceGO:0010035960.074
Mouse
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayGO:190102870.074
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190073930.073
ribonucleoside catabolic processGO:00424542060.073
Worm
erythrocyte differentiationGO:0030218880.073
response to insulinGO:00328681000.073
purine nucleotide biosynthetic processGO:0006164650.073
positive regulation of purine nucleotide metabolic processGO:19005441140.073
Worm
negative regulation of molecular functionGO:00440922580.072
Zebrafish
wound healingGO:00420601570.072
sphingolipid metabolic processGO:0006665450.071
Mouse
glucose metabolic processGO:0006006920.071
myotube differentiationGO:00149021050.071
Mouse
mapk cascadeGO:00001652810.071
mitotic cell cycleGO:00002781950.071
Zebrafish Mouse
chromatin organizationGO:00063252060.070
leukocyte mediated immunityGO:00024431740.069
covalent chromatin modificationGO:00165691630.069
retina development in camera type eyeGO:00600411190.068
Mouse
negative regulation of phosphorylationGO:00423261660.068
Mouse
cytoplasmic transportGO:00164822340.068
Mouse
regulation of lymphocyte proliferationGO:00506701170.067
regulation of protein autophosphorylationGO:003195280.067
positive regulation of cellular carbohydrate metabolic processGO:0010676290.067
endothelial cell differentiationGO:0045446410.067
negative regulation of cell motilityGO:2000146610.067
Mouse
calcium ion homeostasisGO:00550741270.067
Mouse
labyrinthine layer blood vessel developmentGO:0060716210.067
negative regulation of ossificationGO:0030279490.067
Mouse
signal transduction by p53 class mediatorGO:0072331510.066
Mouse
positive regulation of mapk cascadeGO:00434101700.066
positive regulation of leukocyte apoptotic processGO:2000108210.066
Mouse
skeletal system developmentGO:00015013560.066
rna catabolic processGO:0006401290.066
liver developmentGO:0001889660.065
cellular carbohydrate metabolic processGO:00442621190.065
positive regulation of cellular amino acid metabolic processGO:004576430.065
hexose metabolic processGO:0019318980.065
removal of superoxide radicalsGO:0019430120.064
muscle fiber developmentGO:0048747760.064
Mouse
regulation of ossificationGO:00302781120.064
Mouse
ribonucleoside triphosphate metabolic processGO:00091992200.064
Worm
glycosyl compound catabolic processGO:19016582060.064
Worm
regulation of protein complex assemblyGO:0043254830.064
small gtpase mediated signal transductionGO:0007264970.064
activation of innate immune responseGO:0002218560.063
positive regulation of t cell differentiationGO:0045582520.063
regulation of defense responseGO:00313472330.062
labyrinthine layer developmentGO:0060711490.062
regulation of cell sizeGO:0008361720.062
apical constrictionGO:000338340.062
regulation of lymphocyte differentiationGO:00456191070.062
skin morphogenesisGO:0043589380.062
Mouse
organophosphate biosynthetic processGO:00904071220.062
dna damage response signal transduction by p53 class mediatorGO:0030330190.061
peptide hormone secretionGO:00300721090.061
g1 s transition of mitotic cell cycleGO:0000082570.061
Mouse
response to lipopolysaccharideGO:00324961280.061
chromosome segregationGO:0007059480.061
negative regulation of intracellular transportGO:0032387380.061
Mouse
purine nucleotide catabolic processGO:00061952110.060
Worm
interferon gamma productionGO:0032609670.060
cell divisionGO:00513011200.060
Zebrafish
regulation of cell activationGO:00508652890.060
intracellular receptor signaling pathwayGO:0030522740.060
cellular divalent inorganic cation homeostasisGO:00725031270.060
Mouse
ossificationGO:00015032160.060
Mouse
peptidyl lysine acetylationGO:0018394450.060
regulation of leukocyte proliferationGO:00706631210.060
cellular response to abiotic stimulusGO:0071214560.059
Mouse
nephron epithelium developmentGO:0072009920.059
Mouse
gastrulationGO:00073691160.059
regulation of hormone levelsGO:00108172110.058
cytokine biosynthetic processGO:0042089680.058
regulation of response to woundingGO:19030341890.058
regulation of b cell differentiationGO:0045577230.058
regulation of cytoplasmic transportGO:19036491120.058
Mouse
lipid transportGO:0006869980.057
regulation of neutrophil differentiationGO:004565820.057
nuclear transportGO:00511691390.057
nucleoside triphosphate metabolic processGO:00091412300.057
Worm
regulation of b cell activationGO:0050864810.057
multicellular organismal homeostasisGO:00488711640.057
Zebrafish Mouse
anatomical structure homeostasisGO:00602491450.057
Zebrafish Mouse
nephron developmentGO:00720061090.057
Mouse
protein alkylationGO:0008213810.056
positive regulation of growthGO:00459271040.055
Mouse
dna modificationGO:0006304500.055
aromatic compound catabolic processGO:00194392860.055
Worm
negative regulation of cellular component organizationGO:00511291940.055
Zebrafish
positive regulation of nuclear transcribed mrna poly a tail shorteningGO:006021340.055
single organism nuclear importGO:1902593950.054
coagulationGO:0050817780.054
epithelial cell morphogenesisGO:0003382410.054
regulation of striated muscle cell differentiationGO:0051153810.054
Mouse
cellular response to lipopolysaccharideGO:0071222770.054
cellular response to hormone stimulusGO:00328701500.054
cellular response to superoxideGO:0071451140.053
muscle system processGO:00030121410.053
regulation of embryonic developmentGO:0045995710.053
b cell differentiationGO:0030183780.052
Mouse
organonitrogen compound biosynthetic processGO:19015661920.052
tyrosine phosphorylation of stat1 proteinGO:004250830.052
cellular response to peptide hormone stimulusGO:0071375920.051
tissue remodelingGO:00487711020.050
Mouse
negative regulation of stem cell differentiationGO:2000737140.050
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediatorGO:0042771240.050
negative regulation of apoptotic signaling pathwayGO:20012341040.050
Human Mouse
regulation of nucleotide metabolic processGO:00061401690.050
Worm
regulation of secretion by cellGO:19035302490.048
positive regulation of defense responseGO:00313491240.048
nucleoside triphosphate catabolic processGO:00091432050.048
Worm
regulation of stem cell differentiationGO:2000736500.048
viral life cycleGO:0019058360.048
Mouse
pattern recognition receptor signaling pathwayGO:0002221470.047
ras protein signal transductionGO:0007265770.047
cellular response to cytokine stimulusGO:00713451890.047
response to acid chemicalGO:00011011110.047
Mouse
meiotic cell cycleGO:00513211220.047
ear developmentGO:00435832000.047
Mouse
regulation of chromatin modificationGO:1903308570.047
regulation of kinase activityGO:00435492490.047
b cell activationGO:00421131610.047
Mouse
protein importGO:00170381010.046
regulation of response to biotic stimulusGO:0002831380.046
cellular response to biotic stimulusGO:0071216920.046
meiotic nuclear divisionGO:00071261150.046
organelle fissionGO:00482851700.046
Zebrafish
t cell proliferationGO:00420981200.045
Mouse
regulation of microvillus assemblyGO:003253430.045
cellular homeostasisGO:00197252400.045
Mouse
regulation of synaptic vesicle exocytosisGO:2000300110.044
positive regulation of smooth muscle cell migrationGO:001491140.044
Mouse
rna 3 end processingGO:0031123200.044
positive regulation of cell activationGO:00508671580.044
response to nutrient levelsGO:00316671090.044
Mouse
lung developmentGO:00303241640.044
regulation of t cell differentiationGO:0045580830.044
purine ribonucleoside catabolic processGO:00461302050.044
Worm
jnk cascadeGO:0007254720.044
positive regulation of alpha beta t cell differentiationGO:0046638280.044
posttranscriptional regulation of gene expressionGO:00106081550.043
Mouse
ribonucleotide catabolic processGO:00092612080.043
Worm
positive regulation of kinase activityGO:00336741550.043
peptide secretionGO:00027901140.043
regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902041220.043
cytokine mediated signaling pathwayGO:00192211150.043
negative regulation of immune system processGO:00026832090.043
positive regulation of leukocyte proliferationGO:0070665730.042
carbohydrate derivative biosynthetic processGO:19011371830.042
Mouse
regulation of microvillus organizationGO:003253030.042
regulation of tyrosine phosphorylation of stat1 proteinGO:004251020.042
divalent metal ion transportGO:00708381720.042
Mouse
negative regulation of inflammatory responseGO:0050728610.042
regulation of interleukin 8 productionGO:003267730.042
regulation of protein acetylationGO:1901983220.041
negative regulation of cytokine productionGO:0001818840.041
negative regulation of hydrolase activityGO:0051346710.041
Zebrafish
myoblast differentiationGO:0045445520.041
generation of precursor metabolites and energyGO:00060911030.041
organic hydroxy compound transportGO:0015850930.041
regulation of ion transportGO:00432692150.040
Mouse
regulation of neuron projection developmentGO:00109751690.040
negative regulation of leukocyte differentiationGO:1902106510.040
cellular response to lipidGO:00713961450.040
negative regulation of cell cycleGO:00457861230.040
Zebrafish Mouse
carbohydrate derivative catabolic processGO:19011362310.040
Worm
rna processingGO:00063961050.040
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.040
negative regulation of protein transportGO:0051224460.040
dephosphorylationGO:00163111290.039
Mouse
appendage morphogenesisGO:00351071490.039
Mouse
lipid localizationGO:00108761260.039
amide transportGO:00428861380.039
epithelial tube morphogenesisGO:00605623030.039
Mouse
inflammatory responseGO:00069542440.039
negative regulation of tumor necrosis factor biosynthetic processGO:004253610.038
cellular response to organic cyclic compoundGO:0071407870.038
guanosine containing compound catabolic processGO:19010691440.038
Worm
regulation of cellular catabolic processGO:00313292420.038
Worm
regulation of protein localization to nucleusGO:1900180600.038
t helper cell differentiationGO:0042093280.038
gliogenesisGO:00420631410.038
modification dependent macromolecule catabolic processGO:00436321330.037
regulation of erk1 and erk2 cascadeGO:0070372710.037
negative regulation of mitotic cell cycleGO:0045930580.037
Zebrafish Mouse
positive regulation of cellular amine metabolic processGO:003324050.037
ribose phosphate biosynthetic processGO:0046390590.037
mesenchymal cell differentiationGO:00487621070.037
Mouse
response to oxygen radicalGO:0000305160.037
negative regulation of organelle organizationGO:0010639900.037
Zebrafish
regulation of mrna stabilityGO:0043488230.037
hepaticobiliary system developmentGO:0061008670.037
regulation of system processGO:00440572000.037
positive regulation of nucleotide metabolic processGO:00459811140.037
Worm
regulation of cellular component sizeGO:00325351210.037
positive regulation of gene silencing by mirnaGO:200063710.036
syncytium formation by plasma membrane fusionGO:0000768420.036
negative regulation of defense responseGO:0031348770.036
positive regulation of fat cell differentiationGO:0045600320.036
regulation of osteoclast differentiationGO:0045670360.036
negative regulation of multi organism processGO:0043901680.036
cellularizationGO:000734910.036
intracellular protein transportGO:00068862040.035
negative regulation of t cell activationGO:0050868650.035
negative regulation of neuron deathGO:1901215980.035
Mouse
endothelium developmentGO:0003158450.035
neural tube developmentGO:00219151600.035
nuclear divisionGO:00002801580.035
Zebrafish
nucleocytoplasmic transportGO:00069131390.035
cell adhesionGO:00071553290.034
Mouse
response to drugGO:0042493750.034
Mouse
skeletal muscle cell differentiationGO:0035914660.034
regulation of response to dna damage stimulusGO:2001020340.034
Human
cell activation involved in immune responseGO:00022631260.034
dendrite developmentGO:00163581150.034
somitogenesisGO:0001756690.034
hexose transportGO:0008645560.034
positive regulation of podosome assemblyGO:007180330.034
cytokine metabolic processGO:0042107710.034
purine containing compound catabolic processGO:00725232130.034
Worm
positive regulation of carbohydrate metabolic processGO:0045913300.034
t cell apoptotic processGO:0070231390.034
Mouse
regulation of osteoblast differentiationGO:0045667670.034
nucleoside phosphate metabolic processGO:00067533380.034
Worm

Mcl1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.135
cancerDOID:16200.060
organ system cancerDOID:005068600.047