IMP: Integrative Multi-species Prediction

Mus musculus

19 known processes

Nat8

N-acetyltransferase 8 (GCN5-related, putative)

(Aliases: 0610037O16Rik,Cml4)

Entrez: 68396
Ensembl: ENSMUSG00000030004
UniProtKB: Q9JIY7

Process Predictions
Disease Predictions

Nat8 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
amino acid transmembrane transport	GO:0003333	37	0.416
organic anion transport	GO:0015711	137	0.278
ion transmembrane transport	GO:0034220	361	0.224
anion transmembrane transport	GO:0098656	71	0.221
transmembrane transport	GO:0055085	412	0.195
nitrogen compound transport	GO:0071705	271	0.193	Mouse
glutathione metabolic process	GO:0006749	16	0.166	Human
organic acid transport	GO:0015849	101	0.159
oxidation reduction process	GO:0055114	342	0.155
positive regulation of dopamine uptake involved in synaptic transmission	GO:0051586	2	0.145	Mouse
monocarboxylic acid metabolic process	GO:0032787	191	0.126
cellular lipid metabolic process	GO:0044255	323	0.117
amino acid transport	GO:0006865	61	0.104
regulation of neurotransmitter levels	GO:0001505	87	0.097	Mouse
cation transport	GO:0006812	399	0.095	Mouse
sulfur compound metabolic process	GO:0006790	100	0.086	Human
lipid biosynthetic process	GO:0008610	179	0.084
l amino acid transport	GO:0015807	32	0.083
cation transmembrane transport	GO:0098655	266	0.079
neurotransmitter transport	GO:0006836	76	0.076	Mouse
vitamin d3 metabolic process	GO:0070640	3	0.076
response to organic cyclic compound	GO:0014070	198	0.070
fatty acid metabolic process	GO:0006631	121	0.069
carnitine transport	GO:0015879	3	0.067
carboxylic acid transport	GO:0046942	100	0.066
cellular homeostasis	GO:0019725	240	0.066
synaptic transmission	GO:0007268	329	0.065	Mouse
calcitriol biosynthetic process from calciol	GO:0036378	3	0.065
l alpha amino acid transmembrane transport	GO:1902475	23	0.060
metal ion homeostasis	GO:0055065	189	0.060
cellular alcohol biosynthetic process	GO:0044108	3	0.059
carnitine transmembrane transport	GO:1902603	3	0.057
amino acid betaine transport	GO:0015838	3	0.057
nucleotide metabolic process	GO:0009117	332	0.055
anion transport	GO:0006820	177	0.054
fat soluble vitamin biosynthetic process	GO:0042362	4	0.053
nucleoside phosphate metabolic process	GO:0006753	338	0.052
sensory perception	GO:0007600	245	0.051
steroid metabolic process	GO:0008202	119	0.049
monoamine transport	GO:0015844	33	0.046	Mouse
organic hydroxy compound metabolic process	GO:1901615	203	0.045
cellular amide metabolic process	GO:0043603	58	0.044	Human
nucleobase containing small molecule metabolic process	GO:0055086	352	0.043
cellular response to cadmium ion	GO:0071276	3	0.042
cofactor metabolic process	GO:0051186	80	0.041
sulfur compound transport	GO:0072348	9	0.041
succinate transport	GO:0015744	1	0.041
urate transport	GO:0015747	1	0.040
dopamine uptake	GO:0090494	4	0.039	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.039	Human
cellular chemical homeostasis	GO:0055082	215	0.038
glycosyl compound metabolic process	GO:1901657	246	0.038
purine nucleotide metabolic process	GO:0006163	302	0.038
carbohydrate derivative biosynthetic process	GO:1901137	183	0.037
inorganic ion transmembrane transport	GO:0098660	234	0.037
neurotransmitter uptake	GO:0001504	14	0.037	Mouse
purine containing compound metabolic process	GO:0072521	311	0.037
dopamine uptake involved in synaptic transmission	GO:0051583	4	0.036	Mouse
small molecule catabolic process	GO:0044282	71	0.035
maintenance of location	GO:0051235	89	0.035
secondary alcohol metabolic process	GO:1902652	3	0.035
catecholamine uptake involved in synaptic transmission	GO:0051934	4	0.034	Mouse
positive regulation of catecholamine uptake involved in synaptic transmission	GO:0051944	2	0.034	Mouse
divalent inorganic cation transport	GO:0072511	178	0.033
methionine transport	GO:0015821	1	0.033
ribose phosphate metabolic process	GO:0019693	291	0.032
cellular ketone metabolic process	GO:0042180	84	0.031
purine ribonucleotide metabolic process	GO:0009150	290	0.031
cellular alcohol metabolic process	GO:0044107	3	0.031
regulation of hormone levels	GO:0010817	211	0.031
hormone metabolic process	GO:0042445	86	0.030
regulation of ion transport	GO:0043269	215	0.029	Mouse
regulation of blood pressure	GO:0008217	93	0.029
organic cyclic compound catabolic process	GO:1901361	295	0.029
cellular amine metabolic process	GO:0044106	44	0.028
small molecule biosynthetic process	GO:0044283	132	0.028
response to inorganic substance	GO:0010035	96	0.028
modified amino acid transport	GO:0072337	5	0.028
cellular calcium ion homeostasis	GO:0006874	119	0.028
neutral amino acid transport	GO:0015804	13	0.027
ribonucleotide metabolic process	GO:0009259	291	0.026
carbohydrate metabolic process	GO:0005975	230	0.026
ribonucleoside metabolic process	GO:0009119	245	0.025
regulation of nucleotide metabolic process	GO:0006140	169	0.025
inorganic cation transmembrane transport	GO:0098662	207	0.025
renal tubular secretion	GO:0097254	2	0.025
sodium ion transmembrane transport	GO:0035725	49	0.025
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.025
regulation of transferase activity	GO:0051338	263	0.024
organophosphate biosynthetic process	GO:0090407	122	0.024
calcium ion homeostasis	GO:0055074	127	0.023
glycerolipid metabolic process	GO:0046486	122	0.023
regulation of cellular amine metabolic process	GO:0033238	20	0.023
steroid biosynthetic process	GO:0006694	47	0.023
regulation of cell activation	GO:0050865	289	0.023
peptide metabolic process	GO:0006518	46	0.023	Human
cellular metal ion homeostasis	GO:0006875	151	0.022
nucleoside triphosphate metabolic process	GO:0009141	230	0.022
innate immune response	GO:0045087	157	0.022
sodium ion transport	GO:0006814	73	0.022
vitamin d biosynthetic process	GO:0042368	3	0.022
positive regulation of amine transport	GO:0051954	8	0.022	Mouse
protein localization to organelle	GO:0033365	185	0.022
purine ribonucleoside metabolic process	GO:0046128	241	0.022
regulation of membrane potential	GO:0042391	192	0.022
organic hydroxy compound transport	GO:0015850	93	0.022	Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.021
g protein coupled receptor signaling pathway	GO:0007186	243	0.021
response to light stimulus	GO:0009416	135	0.021
membrane organization	GO:0061024	245	0.021
peptidyl amino acid modification	GO:0018193	336	0.020	Human
divalent inorganic cation homeostasis	GO:0072507	138	0.020
regulation of defense response	GO:0031347	233	0.020
purine nucleotide biosynthetic process	GO:0006164	65	0.020
naphthalene metabolic process	GO:0018931	1	0.020
cytoplasmic transport	GO:0016482	234	0.020
cellular response to inorganic substance	GO:0071241	37	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.020
inter male aggressive behavior	GO:0002121	3	0.020
heterocycle catabolic process	GO:0046700	280	0.020
sequestering of metal ion	GO:0051238	19	0.019
amine metabolic process	GO:0009308	45	0.019
cation homeostasis	GO:0055080	212	0.019
transmission of nerve impulse	GO:0019226	76	0.019
naphthalene containing compound metabolic process	GO:0090420	1	0.019
nucleoside monophosphate metabolic process	GO:0009123	85	0.019
aromatic compound catabolic process	GO:0019439	286	0.019
multicellular organismal signaling	GO:0035637	91	0.019
organonitrogen compound biosynthetic process	GO:1901566	192	0.018
response to radiation	GO:0009314	165	0.018
carbohydrate derivative catabolic process	GO:1901136	231	0.018
c4 dicarboxylate transport	GO:0015740	3	0.018
purine nucleoside metabolic process	GO:0042278	241	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.018
regulation of purine nucleotide metabolic process	GO:1900542	169	0.018
action potential	GO:0001508	78	0.018
carboxylic acid biosynthetic process	GO:0046394	86	0.018
nucleotide biosynthetic process	GO:0009165	78	0.018
regulation of cellular ketone metabolic process	GO:0010565	66	0.018
organophosphate catabolic process	GO:0046434	232	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.018
renal system process	GO:0003014	48	0.018
neuronal action potential	GO:0019228	54	0.017
inflammatory response	GO:0006954	244	0.017
response to steroid hormone	GO:0048545	56	0.017
cellular nitrogen compound catabolic process	GO:0044270	280	0.017
actin filament organization	GO:0007015	113	0.017
nucleoside phosphate biosynthetic process	GO:1901293	79	0.016
organonitrogen compound catabolic process	GO:1901565	264	0.016
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.016
organic hydroxy compound biosynthetic process	GO:1901617	77	0.016
pyruvate transport	GO:0006848	2	0.016
vascular process in circulatory system	GO:0003018	62	0.016
nucleoside phosphate catabolic process	GO:1901292	222	0.016
carnitine metabolic process	GO:0009437	7	0.016
purine ribonucleotide catabolic process	GO:0009154	208	0.016
blood circulation	GO:0008015	195	0.016
diterpenoid biosynthetic process	GO:0016102	7	0.016
regulation of intracellular transport	GO:0032386	159	0.016
progesterone metabolic process	GO:0042448	4	0.016
macromolecule catabolic process	GO:0009057	281	0.015
purine containing compound catabolic process	GO:0072523	213	0.015
response to stilbenoid	GO:0035634	22	0.015
protein targeting	GO:0006605	143	0.015
mapk cascade	GO:0000165	281	0.015
vitamin metabolic process	GO:0006766	23	0.015
purine containing compound biosynthetic process	GO:0072522	70	0.015
cellular ion homeostasis	GO:0006873	165	0.015
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.015
protein catabolic process	GO:0030163	221	0.015
defense response to other organism	GO:0098542	197	0.015
response to lipopolysaccharide	GO:0032496	128	0.014
response to extracellular stimulus	GO:0009991	127	0.014
lipid localization	GO:0010876	126	0.014
dopamine transport	GO:0015872	15	0.014	Mouse
nucleoside catabolic process	GO:0009164	206	0.014
catecholamine uptake	GO:0090493	4	0.014	Mouse
nucleoside metabolic process	GO:0009116	246	0.014
regulation of cellular amino acid metabolic process	GO:0006521	5	0.014
regulation of lipid metabolic process	GO:0019216	118	0.014
organic acid biosynthetic process	GO:0016053	86	0.014
regulation of multi organism process	GO:0043900	111	0.014
regulation of circadian sleep wake cycle sleep	GO:0045187	3	0.014
response to corticosterone	GO:0051412	1	0.014
isoprenoid metabolic process	GO:0006720	29	0.014
regulation of anatomical structure size	GO:0090066	178	0.014
response to phenylpropanoid	GO:0080184	22	0.014
regulation of neurotransmitter transport	GO:0051588	35	0.014	Mouse
monocarboxylic acid biosynthetic process	GO:0072330	61	0.014
nucleocytoplasmic transport	GO:0006913	139	0.013
amide transport	GO:0042886	138	0.013
terpenoid metabolic process	GO:0006721	25	0.013
protein import	GO:0017038	101	0.013
cytosolic calcium ion homeostasis	GO:0051480	70	0.013
regulation of protein localization	GO:0032880	231	0.013
response to metal ion	GO:0010038	47	0.013
positive regulation of dopamine secretion	GO:0033603	2	0.013
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.013
nuclear transport	GO:0051169	139	0.013
coenzyme metabolic process	GO:0006732	52	0.013
regulation of dopamine uptake involved in synaptic transmission	GO:0051584	2	0.013	Mouse
purine ribonucleotide biosynthetic process	GO:0009152	59	0.013
alcohol metabolic process	GO:0006066	116	0.013
negative regulation of immune system process	GO:0002683	209	0.013
c21 steroid hormone biosynthetic process	GO:0006700	3	0.013
locomotory behavior	GO:0007626	195	0.013
chemotaxis	GO:0006935	247	0.013
uronic acid metabolic process	GO:0006063	2	0.013
cellular response to lipid	GO:0071396	145	0.013
alcohol biosynthetic process	GO:0046165	43	0.013
purine nucleotide catabolic process	GO:0006195	211	0.013
adult behavior	GO:0030534	135	0.013
activation of immune response	GO:0002253	138	0.013
positive regulation of hydrolase activity	GO:0051345	148	0.013
sequestering of calcium ion	GO:0051208	18	0.013
midgut development	GO:0007494	4	0.013
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.013
myeloid cell differentiation	GO:0030099	233	0.012
positive regulation of defense response	GO:0031349	124	0.012
detection of chemical stimulus involved in sensory perception of taste	GO:0050912	3	0.012
circulatory system process	GO:0003013	197	0.012
sensory perception of light stimulus	GO:0050953	54	0.012
peptide hormone secretion	GO:0030072	109	0.012
protein import into nucleus	GO:0006606	95	0.012
thiamine transport	GO:0015888	2	0.012
ribonucleoside catabolic process	GO:0042454	206	0.012
protein maturation	GO:0051604	176	0.012
divalent metal ion transport	GO:0070838	172	0.012
cellular response to oxidative stress	GO:0034599	76	0.012
positive regulation of innate immune response	GO:0045089	80	0.012
response to organonitrogen compound	GO:0010243	246	0.012
regulation of response to wounding	GO:1903034	189	0.012
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.012
purine nucleoside catabolic process	GO:0006152	205	0.012
regulation of innate immune response	GO:0045088	91	0.012
cell adhesion	GO:0007155	329	0.012
t cell activation	GO:0042110	289	0.012
amino acid betaine metabolic process	GO:0006577	7	0.012
cyclic nucleotide biosynthetic process	GO:0009190	44	0.012
testosterone biosynthetic process	GO:0061370	2	0.012
immune response regulating signaling pathway	GO:0002764	125	0.012
regulation of cellular catabolic process	GO:0031329	242	0.012
regulation of system process	GO:0044057	200	0.012
atp metabolic process	GO:0046034	75	0.012
tripeptide transport	GO:0042939	1	0.012
androgen biosynthetic process	GO:0006702	4	0.012
norepinephrine transport	GO:0015874	2	0.012
vitamin transport	GO:0051180	10	0.012
regulation of organelle organization	GO:0033043	289	0.012
response to drug	GO:0042493	75	0.012
response to reactive oxygen species	GO:0000302	56	0.012
regulation of systemic arterial blood pressure	GO:0003073	61	0.012
retinoid metabolic process	GO:0001523	24	0.012
response to molecule of bacterial origin	GO:0002237	143	0.012
nucleotide catabolic process	GO:0009166	217	0.012
negative regulation of sterol transport	GO:0032372	4	0.011
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.011
vitamin transmembrane transport	GO:0035461	4	0.011
ras protein signal transduction	GO:0007265	77	0.011
response to mineralocorticoid	GO:0051385	1	0.011
fatty acid derivative metabolic process	GO:1901568	33	0.011
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.011
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.011
isoprenoid catabolic process	GO:0008300	2	0.011
response to nutrient levels	GO:0031667	109	0.011
leukocyte differentiation	GO:0002521	342	0.011
cytokine metabolic process	GO:0042107	71	0.011
catecholamine transport	GO:0051937	21	0.011	Mouse
sterol homeostasis	GO:0055092	45	0.011
regulation of circadian sleep wake cycle	GO:0042749	3	0.011
nucleoside triphosphate catabolic process	GO:0009143	205	0.011
regulation of cell projection organization	GO:0031344	206	0.011
regulation of ion transmembrane transport	GO:0034765	119	0.011
cellular phosphate ion homeostasis	GO:0030643	2	0.011
muscle contraction	GO:0006936	101	0.011
cellular lipid catabolic process	GO:0044242	52	0.011
ribonucleotide catabolic process	GO:0009261	208	0.011
succinate transmembrane transport	GO:0071422	1	0.011
cellular response to organic cyclic compound	GO:0071407	87	0.011
icosanoid metabolic process	GO:0006690	33	0.011
regulation of nucleoside metabolic process	GO:0009118	130	0.011
regulation of feeding behavior	GO:0060259	3	0.010
calcium ion transport	GO:0006816	159	0.010
adult locomotory behavior	GO:0008344	91	0.010
positive regulation of cellular amine metabolic process	GO:0033240	5	0.010
regulation of neurotransmitter uptake	GO:0051580	6	0.010	Mouse
glycine transport	GO:0015816	4	0.010
response to testosterone	GO:0033574	3	0.010
exocytosis	GO:0006887	121	0.010
response to oxidative stress	GO:0006979	123	0.010
chemokine mediated signaling pathway	GO:0070098	17	0.010
sensory perception of chemical stimulus	GO:0007606	51	0.010
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.010
small gtpase mediated signal transduction	GO:0007264	97	0.010
positive regulation of nucleotide metabolic process	GO:0045981	114	0.010
defense response to bacterium	GO:0042742	119	0.010
positive regulation of programmed cell death	GO:0043068	218	0.010
anatomical structure homeostasis	GO:0060249	145	0.010
lymphocyte proliferation	GO:0046651	164	0.010
regulation of blood vessel size	GO:0050880	56	0.010
transition metal ion transport	GO:0000041	38	0.010
glycoprotein metabolic process	GO:0009100	116	0.010
intracellular protein transport	GO:0006886	204	0.010
positive regulation of cell activation	GO:0050867	158	0.010

Nat8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.029
disease of anatomical entity	DOID:7	0.022
nervous system disease	DOID:863	0.022
inherited metabolic disorder	DOID:655	0.018
lipid metabolism disorder	DOID:3146	0.017
disease of cellular proliferation	DOID:14566	0.017
cancer	DOID:162	0.017
organ system cancer	DOID:0050686	0.017
steroid inherited metabolic disorder	DOID:1701	0.016

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